Fibromyalgia (FMS)

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Disease Ontology 11 DOID:631 MeSH 43 D005356 NCIt 49 C87497 SNOMED-CT 68 1304004

ICD10 31 M79.7 EFO 16 EFO_0005687 UMLS 71 C0016053 C0027073

MedlinePlus: ⁴¹ What is fibromyalgia? Fibromyalgia is chronic condition that causes pain all over the body, fatigue, and other symptoms. People with fibromyalgia may be more sensitive to pain than people who don't have it. This is called abnormal pain perception processing. What causes fibromyalgia? The exact cause of fibromyalgia is unknown. Researchers think that certain things might contribute to its cause: Stressful or traumatic events, such as car accidents Repetitive injuries Illnesses such as viral infections Sometimes, fibromyalgia can develop on its own. It can run in families, so genes may play a role in the cause. Who is at risk for fibromyalgia? Anyone can get fibromyalgia, but it is more common in: Women; they are twice as likely to have fibromyalgia Middle-aged people People with certain diseases, such as lupus, rheumatoid arthritis, or ankylosing spondylitis People who have a family member with fibromyalgia What are the symptoms of fibromyalgia? Common symptoms of fibromyalgia include: Pain and stiffness all over the body Fatigue and tiredness Problems with thinking, memory, and concentration (sometimes called "fibro fog") Depression and anxiety Headaches, including migraines Irritable bowel syndrome Numbness or tingling in the hands and feet Pain in the face or jaw, including disorders of the jaw know as temporomandibular joint syndrome (TMJ) Sleep problems How is fibromyalgia diagnosed? Fibromyalgia can be hard to diagnose. It sometimes takes visits to several different health care providers to get a diagnosis. One problem is that there isn't a specific test for it. And the main symptoms, pain and fatigue, are common in many other conditions. Health care providers have to rule out other causes of the symptoms before making a diagnosis of fibromyalgia. This is called making a differential diagnosis. TYour health care provider may use many tools to make a diagnosis: A medical history, including asking detailed questions about your symptoms A physical exam X-rays and blood tests to rule out other conditions The guidelines for diagnosing fibromyalgia, which include A history of widespread pain lasting more than 3 months Physical symptoms including fatigue, waking unrefreshed, and cognitive (memory or thought) problems The number of areas throughout the body in which you had pain in the past week What are the treatments for fibromyalgia? Not all health care providers are familiar with fibromyalgia and its treatment. You should see a doctor or team of health care providers who specialize in the treatment of fibromyalgia. Fibromyalgia is treated with a combination of treatments, which may include medicines, lifestyle changes, talk therapy, and complementary therapies: Medicines Over-the-counter pain relievers Prescription medicines that were specifically approved to treat fibromyalgia Prescription pain medicines Certain antidepressants, which may help with pain or sleep problems Lifestyle changes Getting enough sleep Getting regular physical activity. If you have not already been active, start slowly and gradually increase how much activity you get. You may want to see a physical therapist, who can help you create a plan that is right for you. Learning how to manage stress Eating a healthy diet Learning to pace yourself. If you do too much, it can make your symptoms worse. So you need to learn to balance being active with your need for rest. Talk therapy, such as cognitive behavioral therapy (CBT), can help you learn strategies to deal with pain, stress, and negative thoughts. If you also have depression along with your fibromyalgia, talk therapy can help with that too. Complementary therapies have helped some people with the symptoms of fibromyalgia. But researchers need to do more studies to show which ones are effective. You could consider trying them, but you should check with your health care provider first. These therapies include Massage therapy Movement therapies Chiropractic therapy Acupuncture

MalaCards based summary: Fibromyalgia, also known as fibromyalgia-fibromyositis syndrome, is related to chronic pain and myofascial pain syndrome, and has symptoms including muscle weakness, fatigue and myoclonus. An important gene associated with Fibromyalgia is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways are GPCR downstream signalling and Class A/1 (Rhodopsin-like receptors). The drugs Etoricoxib and Fluoxetine have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and skeletal muscle, and related phenotypes are homeostasis/metabolism and nervous system

MedlinePlus Genetics: ⁴² Fibromyalgia is a common condition characterized by long-lasting (chronic) pain affecting many areas of the body. The pain is associated with tenderness that occurs with touch or pressure on the muscles, joints, or skin. Some affected individuals also report numbness, tingling, or a burning sensation (paresthesia) in the arms and legs.Other signs and symptoms of fibromyalgia include excessive tiredness (exhaustion); sleep problems, such as waking up feeling unrefreshed; and problems with memory or thinking clearly. People with fibromyalgia often report additional types of pain, including headaches, back and neck pain, sore throat, pain or clicking in the jaw (temporomandibular joint dysfunction), and stomach pain or digestive disorders such as irritable bowel syndrome. They have an increased likelihood of developing mood or psychiatric disorders including depression, anxiety, and obsessive-compulsive disorder. However, many people with fibromyalgia do not have a mental health condition.The major signs and symptoms of fibromyalgia can occur by themselves or together with another chronic pain condition such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, or systemic lupus erythematosus.

PubMed Health : ⁶³ Fibromyalgia: Fibromyalgia (also known as fibromyalgia syndrome or FMS) is a chronic condition that causes pain in various parts of the body. The pain may be felt in the skin, muscles and joints. Other typical symptoms include sleep problems, exhaustion and trouble concentrating. Although fibromyalgia has been recognized as an illness for 30 years now, people who have it are still sometimes made to feel like it’s all in their head. Part of the reason for this is that not many people are aware of fibromyalgia, and healthy people find it hard to understand. This often makes it even harder to live with the condition. Sometimes people who have fibromyalgia are told that the pain can’t be treated. But research has shown that there are indeed treatments that can relieve the typical symptoms. And many people learn to cope better with the pain over time. They find out what activities they can handle – and when to take things easier. It’s good to know that fibromyalgia isn’t a dangerous condition. It doesn’t affect people’s organs or life expectancy.

CDC: ² Fibromyalgia (fi·bro·my·al·gi·a) is a condition that causes pain all over the body (also referred to as widespread pain), sleep problems, fatigue, and often emotional and mental distress. People with fibromyalgia may be more sensitive to pain than people without fibromyalgia. This is called abnormal pain perception processing. Fibromyalgia affects about 4 million US adults, about 2% of the adult population. The cause of fibromyalgia is not known, but it can be effectively treated and managed.

Disease Ontology: ¹¹ A syndrome that is is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbances, cognitive dysfunction and depression.

Wikipedia: ⁷⁵ Fibromyalgia (FM) is a medical condition defined by the presence of chronic widespread pain, fatigue,... more...

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	no effect	GR00402-S-1	10.17	BDNF CALCA COMT CRH CRP CXCL8
2	no effect	GR00402-S-2	10.17	BDNF CALCA COMT CRH CRP GRIN2D

Many people who have fibromyalgia avoid physical activity for fear of making the pain worse or overdoing it. But research has shown that exercise and gentle sports (e.g. cycling or Nordic walking) can improve their wellbeing, strengthen their body and relieve the pain somewhat. So they are an important part of the treatment . Certain medications have been proven to greatly reduce fibromyalgia pain in some people. These include amitriptyline , duloxetine , milnacipran and pregabalin . They all influence certain chemical messengers that also affect how we feel pain. These drugs were originally developed for the treatment of depression or epilepsy . When used in the treatment of fibromyalgia, though, they aren’t used for their antidepressant or anti-epileptic effects. Conventional painkillers such as diclofenac , ibuprofen or acetaminophen (paracetamol) generally aren’t recommended for the treatment of fibromyalgia. Many people with fibromyalgia find certain types of physical therapy to be pleasant, especially resting and/or moving in warm water. Some also say that going to the sauna or having gentle massages help. Multimodal pain management can be a good idea, particularly if the fibromyalgia pain is strong. This approach combines movement, relaxation and pain management techniques used in cognitive behavioral therapy (CBT). CBT and other psychological treatments can help people to cope better with pain and other symptoms in everyday life. Medication can be used as well. If someone also has other illnesses such as arthritis or psychological problems such as depression , it’s important to treat those conditions too.

Search NIH Clinical Center for Fibromyalgia

Search GEO for disease gene expression data for Fibromyalgia.