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MCID: FBR047
MIFTS: 57

Fibromyalgia

Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Fibromyalgia

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MalaCards integrated aliases for Fibromyalgia:

Name: Fibromyalgia 25 37 55 43 3 63 73
Fibromyalgia-Fibromyositis Syndrome 25
Diffuse Myofascial Pain Syndrome 25
Myofascial Pain Syndromes 73
Myofascial Pain Syndrome 25
Fibromyalgia Syndrome 25
Fibromyositis 25
Fibrositis 25
Fms 25

Classifications:

ICD10: 33


External Ids:

KEGG 37 H01636
ICD10 33 M79.7
UMLS 73 C0016053
Sources

Summaries for Fibromyalgia

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PubMed Health : 63 About fibromyalgia: Fibromyalgia (also known as fibromyalgia syndrome or FMS) is a chronic condition that causes pain in various parts of the body. The pain may be felt in the skin, muscles and joints. Other typical symptoms include sleep problems, exhaustion and trouble concentrating.Although fibromyalgia has been recognized as an illness for 30 years now, people who have it are still sometimes made to feel like it’s all in their head. Part of the reason for this is that not many people are aware of fibromyalgia, and healthy people find it hard to understand. This often makes it even harder to live with the condition.Sometimes people who have fibromyalgia are told that the pain can’t be treated. But research has shown that there are indeed treatments that can relieve the typical symptoms. And many people learn to cope better with the pain over time. They find out what activities they can handle – and when to take things easier.It’s good to know that fibromyalgia isn’t a dangerous condition. It doesn’t affect people’s organs or life expectancy.

MalaCards based summary : Fibromyalgia, also known as fibromyalgia-fibromyositis syndrome, is related to alexithymia and bruxism, and has symptoms including back pain, fatigue and muscle cramp. An important gene associated with Fibromyalgia is GRIN2D (Glutamate Ionotropic Receptor NMDA Type Subunit 2D), and among its related pathways/superpathways are CREB Pathway and Circadian rythm related genes. The drugs Lidocaine and Menthol have been mentioned in the context of this disorder. Affiliated tissues include skin, brain and testes, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Genetics Home Reference : 25 Fibromyalgia is a common condition characterized by long-lasting (chronic) pain affecting many areas of the body. The pain is associated with tenderness that occurs with touch or pressure on the muscles, joints, or skin. Some affected individuals also report numbness, tingling, or a burning sensation (paresthesia) in the arms and legs.

MedlinePlus : 43 Fibromyalgia is a disorder that causes muscle pain and fatigue. People with fibromyalgia have "tender points" on the body. Tender points are specific places on the neck, shoulders, back, hips, arms, and legs. These points hurt when pressure is put on them. People with fibromyalgia may also have other symptoms, such as Trouble sleeping Morning stiffness Headaches Painful menstrual periods Tingling or numbness in hands and feet Problems with thinking and memory (sometimes called "fibro fog") No one knows what causes fibromyalgia. Anyone can get it, but it is most common in middle-aged women. People with rheumatoid arthritis and other autoimmune diseases are particularly likely to develop fibromyalgia. There is no cure for fibromyalgia, but medicine can help you manage your symptoms. Getting enough sleep, exercising, and eating well may also help. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

CDC : 3 Fibromyalgia (fi·bro·my·al·gi·a) is a condition that causes pain all over the body (also referred to as widespread pain), sleep problems, fatigue, and often emotional and mental distress. People with fibromyalgia may be more sensitive to pain than people without fibromyalgia. This is called abnormal pain perception processing. Fibromyalgia affects about 4 million US adults, about 2% of the adult population. The cause of fibromyalgia is not known, but it can be effectively treated and managed.

Wikipedia : 76 Fibromyalgia (FM) is a medical condition characterised by chronic widespread pain and a heightened pain... more...

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Related Diseases for Fibromyalgia

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Diseases related to Fibromyalgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
# Related Disease Score Top Affiliating Genes
1 alexithymia 30.4 COMT IL6 SLC6A4
2 bruxism 30.1 HTR2A SLC6A4
3 irritable bowel syndrome 30.1 CRH HTR3A SLC6A4
4 depression 30.0 CRH HTR2A HTR3A SLC6A4
5 apnea, obstructive sleep 29.8 HTR2A IL6
6 chronic fatigue syndrome 29.7 COMT CRH IGF1 IL6 SLC6A4
7 serotonin syndrome 29.7 HTR2A HTR3A SLC6A4
8 opioid addiction 29.6 COMT GRIN2D
9 sleep apnea 29.6 HTR2A IGF1 IL6
10 complex regional pain syndrome 29.2 IL6 NPY
11 post-traumatic stress disorder 28.8 COMT CRH HTR2A SLC6A4
12 disease of mental health 28.8 COMT CRH HTR2A SLC6A4
13 eating disorder 28.5 COMT CRH NPY SLC6A4
14 bipolar disorder 27.7 COMT CRH HTR2A HTR3A IGF1 SLC6A4
15 panic disorder 27.3 COMT CRH HTR2A HTR3A SLC6A4 TSPO
16 mood disorder 27.1 COMT CRH HTR2A IL6 NPY SLC6A4
17 anxiety 26.8 COMT CRH HTR2A HTR3A NPY SLC6A4
18 major depressive disorder 26.4 COMT CRH HTR2A HTR3A IL6 NPY
19 poikiloderma, hereditary fibrosing, with tendon contractures, myopathy, and pulmonary fibrosis 12.4
20 frontal fibrosing alopecia 12.3
21 fibrosing mediastinitis 12.3
22 pulmonary fibrosis, idiopathic 12.0
23 riedel's fibrosing thyroiditis 11.9
24 nephrogenic systemic fibrosis 11.8
25 lichen planopilaris 11.7
26 interstitial cystitis 11.3
27 myofascial pain syndrome 11.3
28 chronic pain 11.2
29 postural orthostatic tachycardia syndrome 11.2
30 idiopathic interstitial pneumonia 11.2
31 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 11.1
32 localized scleroderma 11.0
33 cyanosis, transient neonatal 10.9
34 endocarditis 10.9
35 infective endocarditis 10.9
36 thoracic outlet syndrome 10.9
37 stiff-person syndrome 10.9
38 sclerosing cholangitis 10.8
39 congenital hepatic fibrosis 10.8
40 mammographic density 10.7 COMT IGF1
41 alopecia 10.7
42 cyclic vomiting syndrome 10.6 HTR3A IL6
43 mediastinitis 10.6
44 phobic disorder 10.6 COMT SLC6A4
45 tardive dyskinesia 10.6 COMT HTR2A
46 schizophrenia 5 10.6 HTR2A HTR3A
47 social phobia 10.6 HTR3A SLC6A4
48 oppositional defiant disorder 10.5 COMT SLC6A4
49 alzheimer disease 5 10.5 HTR2A SLC6A4
50 sheehan syndrome 10.5 CRH IGF1

Graphical network of the top 20 diseases related to Fibromyalgia:



Diseases related to Fibromyalgia
Sources

Symptoms & Phenotypes for Fibromyalgia

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UMLS symptoms related to Fibromyalgia:


back pain, fatigue, muscle cramp, muscle rigidity, muscle spasticity, myoclonus, pain, sciatica, torticollis, chronic pain, muscle weakness, myalgia, myofascial trigger point pain

MGI Mouse Phenotypes related to Fibromyalgia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.09 COMT CRH GRIN2D HTR2A HTR3A IL6
2 endocrine/exocrine gland MP:0005379 10.01 COMT CRH HTR2A HTR3A IGF1 IL6
3 growth/size/body region MP:0005378 9.97 NPY SLC6A4 TSPO CRH GRIN2D HTR3A
4 homeostasis/metabolism MP:0005376 9.97 IL6 NPY SLC6A4 TSPO COMT CRH
5 adipose tissue MP:0005375 9.85 CRH GRIN2D IGF1 IL6 NPY
6 nervous system MP:0003631 9.76 COMT CRH GRIN2D HTR3A IGF1 IL6
7 integument MP:0010771 9.73 CRH GRIN2D HTR3A IGF1 IL6 SLC6A4
8 renal/urinary system MP:0005367 9.43 COMT CRH HTR3A IGF1 IL6 NPY
9 skeleton MP:0005390 9.1 CRH GRIN2D HTR2A IGF1 IL6 NPY
Sources

Drugs & Therapeutics for Fibromyalgia

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PubMedHealth treatment related to Fibromyalgia: 63

Many people who have fibromyalgia avoid physical activity for fear of making the pain worse or overdoing it. But research has shown that exercise and gentle sports (e.g. cycling or Nordic walking) can improve their wellbeing, strengthen their body and relieve the pain somewhat. So they are an important part of the treatment.Certain medications have been proven to greatly reduce fibromyalgia pain in some people. These include amitriptyline, duloxetine, milnacipran and pregabalin. They all influence certain chemical messengers that also affect how we feel pain. These drugs were originally developed for the treatment of depression or epilepsy. When used in the treatment of fibromyalgia, though, they aren’t used for their antidepressant or anti-epileptic effects. Conventional painkillers such as diclofenac, ibuprofen or acetaminophen (paracetamol) generally aren’t recommended for the treatment of fibromyalgia.Many people with fibromyalgia find certain types of physical therapy to be pleasant, especially resting and/or moving in warm water. Some also say that going to the sauna or having gentle massages help.Multimodal pain management can be a good idea, particularly if the fibromyalgia pain is strong. This approach combines movement, relaxation and pain management techniques used in cognitive behavioral therapy (CBT). CBT and other psychological treatments can help people to cope better with pain and other symptoms in everyday life. Medication can be used as well.If someone also has other illnesses such as arthritis or psychological problems such as depression, it’s important to treat those conditions too.

Drugs for Fibromyalgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 350)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
2
Menthol Approved Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable 2216-51-5 16666
3
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
4
Dopamine Approved Phase 4,Phase 3,Phase 2,Not Applicable 51-61-6, 62-31-7 681
5
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1 51-84-3 187
6
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2 27203-92-5 33741
7
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
8
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 60142-96-3 3446
9
Amitriptyline Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-48-6 2160
10
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 148553-50-8 5486971
11
Naloxone Approved, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 465-65-6 5284596
12
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Not Applicable 103-90-2 1983
13
Milnacipran Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 92623-85-3 65833
14
Perphenazine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-39-9 4748
15
Benzocaine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
16
Dinoprostone Approved Phase 4 363-24-6 5280360
17
Cyclobenzaprine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 303-53-7 2895
18
gamma-Aminobutyric acid Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 56-12-2 119
19
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1 9004-61-9 53477741
20
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
21
Iron Approved Phase 4,Phase 3,Phase 2 7439-89-6 23925
22
Modafinil Approved, Investigational Phase 4,Phase 3 68693-11-8 4236
23
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
24
Colchicine Approved Phase 4 64-86-8 6167 2833
25
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2 75614-87-8, 51-45-6 774
26
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
27
Paroxetine Approved, Investigational Phase 4,Phase 1,Phase 2 61869-08-7 43815
28
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 2 54910-89-3 3386
29
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
30
Naltrexone Approved, Investigational, Vet_approved Phase 4,Not Applicable 16590-41-3 5360515
31
Deferasirox Approved, Investigational Phase 4 201530-41-8 5493381
32
Armodafinil Approved, Investigational Phase 4,Phase 3 112111-43-0
33
Sodium oxybate Approved Phase 4,Phase 3,Phase 2 502-85-2 5360545
34
Flunarizine Approved Phase 4 52468-60-7 941361
35
Suvorexant Approved, Investigational Phase 4 1030377-33-3
36
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
37
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
38
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
39
Glutamic Acid Approved, Nutraceutical Phase 4,Not Applicable 56-86-0 33032
40 tannic acid Approved, Nutraceutical Phase 4,Phase 1,Phase 2,Not Applicable
41
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
42
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 6221 5280795
43 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
44 calcium channel blockers Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 abobotulinumtoxinA Phase 4,Phase 3,Phase 2,Phase 1
46 Central Nervous System Depressants Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
47 Adrenergic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
48 Micronutrients Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
49 Cholinergic Agents Phase 4,Phase 3,Phase 2,Phase 1
50 GABA Agents Phase 4,Phase 3,Phase 2,Not Applicable

Interventional clinical trials:

(show top 50) (show all 818)
# Name Status NCT ID Phase Drugs
1 Study Assessing the Efficacy of Etoricoxib in Female Patients With Fibromyalgia Unknown status NCT00755521 Phase 4 etoricoxib
2 Study of Fibromyalgia Treated With Milnacipran Unknown status NCT01125423 Phase 4 Milnacipran
3 Cyclobenzaprine Extended Release (ER) for Fibromyalgia Unknown status NCT01041495 Phase 4 cyclobenzaprine ER (AMRIX);placebo
4 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
5 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
6 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
7 Quetiapine Compared With Placebo in the Management of Fibromyalgia Completed NCT01458964 Phase 4 Quetiapine
8 Effect of Milnacipran on Pain in Fibromyalgia Completed NCT01288807 Phase 4 Milnacipram
9 Pool-based Exercise in Fibromyalgia Management Completed NCT00550641 Phase 4
10 Quetiapine (Seroquel XR) for the Treatment of Fibromyalgia: a Clinical and Mechanistic Pilot Study Completed NCT00983320 Phase 4 quetiapine;placebo
11 Strengthening Exercises for Fibromyalgia Completed NCT02063750 Phase 4
12 Comparative Efficacy and Tolerability of Quetiapine XR and Amitriptyline in the Treatment of Fibromyalgia Completed NCT00766350 Phase 4 amitriptyline;quetiapine
13 Paroxetine-CR (Paxil-CR) in the Treatment of Patients With Fibromyalgia Syndrome Completed NCT00610610 Phase 4 Paroxetine CR;Placebo
14 A Pilot Study on the Use of Nociceptive Flexion Reflex for Fibromyalgia Completed NCT00965601 Phase 4
15 Trazodone and Its Augmentation With Pregabalin in the Treatment of Fibromyalgia Completed NCT00791739 Phase 4 trazodone, pregabalin
16 Discomfort and Psychosocial Difficulties in Fibromyalgia Completed NCT02078791 Phase 4 Botox infiltration
17 Discontinuation Study of the Durability of Effect of Milnacipran for the Treatment of Fibromyalgia Completed NCT01014585 Phase 4 Placebo;Milnacipran
18 Adolescent Fibromyalgia Study Completed NCT01020474 Phase 4 placebo;pregabalin (Lyrica)
19 Drug and Talk Therapy for Fibromyalgia Completed NCT01038323 Phase 4 Educational with milnacipran
20 Heart Rate Variability in Fibromyalgia - Effects of Strengthening Exercises Completed NCT02004405 Phase 4
21 Combining N-of-1 Trials to Assess Fibromyalgia Treatments Completed NCT00000428 Phase 4 Amitriptyline;Amitriptyline plus Fluoxitine
22 Fixed Versus Flexible Dosing of Pregabalin in Patients With Fibromyalgia Completed NCT01226667 Phase 4 Pregabalin
23 Ai Chi Versus Stretching in Fibromyalgia Management Completed NCT00600574 Phase 4
24 A Study for Adult Patients With Fibromyalgia Completed NCT00965081 Phase 4 Duloxetine;Placebo
25 A Study to Evaluate the Effects of Milnacipran on Pain Processing and Functional MRI in Patients With Fibromyalgia Completed NCT01173055 Phase 4 milnacipran;Placebo
26 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed NCT01234675 Phase 4 Milnacipran;Milnacipran
27 Pregabalin In Adolescent Patients With Fibromyalgia Completed NCT01020526 Phase 4 pregabalin
28 Eszopiclone in the Treatment of Insomnia and Fibromyalgia Completed NCT00392041 Phase 4 Eszopiclone;placebo
29 Study of Milnacipran in Patients With Inadequate Response to Duloxetine for the Treatment of Fibromyalgia Completed NCT01077375 Phase 4 Placebo;Milnacipran
30 An Efficacy Study of Combination of Tramadol and Acetaminophen Tablets in the Treatment of Participants With Fibromyalgia Pain Completed NCT00766675 Phase 4 Tramadol hydrochloride;Acetaminophen
31 A Study Comparing Duloxetine and Placebo in the Treatment of Fibromyalgia Completed NCT00673452 Phase 4 duloxetine hydrochloride;placebo
32 An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue Completed NCT00678691 Phase 4 armodafinil;placebo
33 A Study of Quetiapine Fumarate Sustained Release in Major Depression With Comorbid Fibromyalgia Syndrome Completed NCT00675896 Phase 4 Quetiapine Fumarate Sustained Release;Placebo
34 Treatment of Myofascial Pain Syndrome With Lidocaine Injection and Physical Therapy. Completed NCT01250184 Phase 4 Lidocaine injection
35 EMINEM: Efficacy of Muscoril In NEck Myofascial Syndromes Completed NCT00272532 Phase 4 Thiocolchicoside
36 Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
37 Patient Self-administration of Cortisol for Cortisol-responding Disorders in Men and Women Over the Age of 17 Completed NCT03558971 Phase 4 Cortisol
38 Milnacipran for Chronic Pain in Knee Osteoarthritis Completed NCT01510457 Phase 4 Milnacipran;Placebo
39 Comparison of the Efficacy of Duloxetine With Placebo in Patients With Chronic Low Back Pain With a Radicular Component Completed NCT01166048 Phase 4 Duloxetine;Duloxetine
40 Efficacy and Safety of Lisdexamfetamine Dimesylate in Adults With Chronic Fatigue Syndrome Completed NCT01071044 Phase 4 Lisdexamfetamine Dimesylate;Placebo "30, 50 or 70 mg"
41 Study on the Effect of Granisetron on Myofascial Pain in the Orofacial Muscles Completed NCT02230371 Phase 4 Granisetron;Control (placebo)
42 Magnetic Resonance Imaging (MRI) Assessments of the Heart and Liver Iron Load in Patients With Transfusion Induced Iron Overload Completed NCT00673608 Phase 4 deferasirox
43 A Double Blind Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for Temporomandibular Joint (TMJ) Dysfunction Completed NCT01524913 Phase 4 Hyaluronic acid;Corticosteroid;Lactated Ringers
44 Valuation of Efficacy and Safety of Vitamin D3 Use in 80 Women Diagnosed With Fibromyalgia. Using FIQ Score and VAS. Recruiting NCT03369379 Phase 4 D3 Vitamin
45 Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? Recruiting NCT02806440 Phase 4 Low dose naltrexone;Placebo
46 Suvorexant in Insomnia Co-morbid With Fibromyalgia Recruiting NCT02684136 Phase 4 suvorexant;placebo
47 Neurologic Signatures of Chronic Pain Disorders Recruiting NCT02747940 Phase 4 flunarizine and/or pregabalin
48 Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty Enrolling by invitation NCT03271151 Phase 4 Cymbalta
49 Influence of Transcranial Direct Current Stimulation of the Primary Motor Cortex on Pain Sensation in Patients Suffering From Fibromyalgia Syndrome Terminated NCT01261650 Phase 4
50 A Study for Adolescents With Fibromyalgia Syndrome Terminated NCT01089621 Phase 4 Duloxetine

Search NIH Clinical Center for Fibromyalgia

Sources

Genetic Tests for Fibromyalgia

About this section
Sources

Anatomical Context for Fibromyalgia

About this section

MalaCards organs/tissues related to Fibromyalgia:

41
Skin, Brain, Testes, Breast, Heart, Cortex, Liver
Sources

Publications for Fibromyalgia

About this section

Articles related to Fibromyalgia:

(show top 50) (show all 1151)
# Title Authors Year
1
SNPs in inflammatory genes CCL11, CCL4 and MEFV in a fibromyalgia family study. ( 29927949 )
2018
2
Pathophysiology and Management of Abdominal Myofascial Pain Syndrome (AMPS): A Three-Year Prospective Audit of a Management Pathway in 120 Patients. ( 29444277 )
2018
3
The subjective components of the Disease Activity Score 28-joints (DAS28) in rheumatoid arthritis patients and coexisting fibromyalgia. ( 29955927 )
2018
4
Pelvic floor dysfunction in women with fibromyalgia and control subjects: Prevalence and impact on overall symptomatology and psychosocial function. ( 29974511 )
2018
5
The Distinction of Hot Herbal Compress, Hot Compress, and Topical Diclofenac as Myofascial Pain Syndrome Treatment. ( 29405762 )
2018
6
Pregabalin Prescription for Neuropathic Pain and Fibromyalgia: A Descriptive Study Using Administrative Database in Japan. ( 29973966 )
2018
7
Psychoeducation against depression, anxiety, alexithymia and fibromyalgia: a pilot study in primary care for patients on sick leave. ( 29693478 )
2018
8
Specific symptoms may discriminate between fibromyalgia patients with vs without objective test evidence of small-fiber polyneuropathy. ( 29430562 )
2018
9
Concurrent validation of a pressure pain threshold scale for individuals with myofascial pain syndrome and fibromyalgia. ( 29456445 )
2018
10
Challenging the Cinderella Hypothesis: A New Model for the Role of the Motor Unit Recruitment Pattern in the Pathogenesis of Myofascial Pain Syndrome in Postural Muscles. ( 29944114 )
2018
11
Evaluation of allergic rhinitis with nasal symptoms and nasal mucociliary clearance in patients with fibromyalgia syndrome. ( 29889054 )
2018
12
Emotional Influences on Cognitive Processing in Fibromyalgia Patients With Different Depression Levels: An Event-related Potential Study. ( 29975206 )
2018
13
Facts and myths pertaining to fibromyalgia. ( 29946212 )
2018
14
The Effectiveness of Dry Needling and Exercise Therapy in Patients with Dizziness Caused By Cervical Myofascial Pain Syndrome; Prospective Randomized Clinical Study. ( 29718418 )
2018
15
Combination of exercise and acupuncture vs acupuncture alone for treatment of myofascial pain syndrome: A randomized clinical trial. ( 29746993 )
2018
16
Prevalence of myofascial pain syndrome in patients with incurable cancer. ( 29861227 )
2018
17
Complex Regional Pain Syndrome After Distal Radius Fracture Is Uncommon and Is Often Associated With Fibromyalgia. ( 29419627 )
2018
18
Rates of Neuropsychological Dysfunction in Fibromyalgia and Rheumatoid Arthritis: An Automated Clinical Rating Approach. ( 29916966 )
2018
19
The relationship with restless legs syndrome, fibromyalgia, and depressive symptoms in migraine patients. ( 29777478 )
2018
20
Validity and test-retest reliability of the Dutch modified Perceived Deficits Questionnaire to examine cognitive symptoms in women with chronic whiplash, chronic idiopathic neck pain and fibromyalgia. ( 29383819 )
2018
21
Methodological Issues on the Accuracy and Precision of Clinical Examination in the Diagnosis of Myofascial Pain Syndrome. ( 29788387 )
2018
22
FIBROMYALGIA AND SMALL FIBER POLYNEUROPATHY: WHAT'S IN A NAME? ( 29938813 )
2018
23
Reply to "Clinical Examination in the Diagnosis of Myofascial Pain Syndrome; Methodological Issues on Validity and Reliability". ( 29788501 )
2018
24
Quantitative Ultrasound Using Texture Analysis of Myofascial Pain Syndrome in the Trapezius. ( 29717675 )
2018
25
Comparision of the effectiveness of ESWT and ultrasound treatments in myofascial pain syndrome: randomized, sham-controlled study. ( 29581669 )
2018
26
Low-level laser therapy combined to functional exercise on treatment of fibromyalgia: a double-blind randomized clinical trial. ( 29931588 )
2018
27
Paresthesia frequency in fibromyalgia and its effects on personality traits. ( 29968325 )
2018
28
Recent insights into 3 underrecognized conditions: Myalgic encephalomyelitis-chronic fatigue syndrome, fibromyalgia, and environmental sensitivities-multiple chemical sensitivity. ( 29898928 )
2018
29
Altered near-infrared spectroscopy response to breath-holding in patients with fibromyalgia. ( 29952139 )
2018
30
The effect of depressive symptoms on cognition in patients with fibromyalgia. ( 29975749 )
2018
31
Randomized, blinded, controlled trial on effectiveness of photobiomodulation therapy and exercise training in the fibromyalgia treatment. ( 29170901 )
2018
32
Association between fibromyalgia syndrome and peptic ulcer disease development. ( 28384332 )
2017
33
Comparision of two different dry-needling techniques in the treatment of myofascial pain syndrome. ( 28467572 )
2017
34
Reliability of assessment of upper trapezius morphology, its mechanical properties and blood flow in female patients with myofascial pain syndrome using ultrasonography. ( 28167187 )
2017
35
Acupuncture for Myofascial Pain Syndrome: A Network Meta-Analysis of 33 Randomized Controlled Trials. ( 28934793 )
2017
36
Far-infrared ray patches relieve pain and improve skin sensitivity in myofascial pain syndrome: A double-blind randomized controlled study. ( 29154057 )
2017
37
Altered central pain processes behind fibromyalgia? Are they restored by antidepressants as indicated by an innovative fMRI-study? ( 29913904 )
2017
38
Undifferentiated connective tissue disease, fibromyalgia and the environmental factors. ( 28368979 )
2017
39
Extracorporeal Shock Wave Therapy Versus Trigger Point Injection in the Treatment of Myofascial Pain Syndrome in the Quadratus Lumborum. ( 28971042 )
2017
40
Assess pain intensity using photoplethysmography signal in chronic myofascial pain syndrome. ( 28502104 )
2017
41
Acute effects of physical exercise on the serum insulin-like growth factor system in women with fibromyalgia. ( 28122522 )
2017
42
Using fMRI to evaluate the effects of milnacipran on central pain processing in patients with fibromyalgia. ( 29913906 )
2017
43
Increased Risk of Myofascial Pain Syndrome Among Patients with Insomnia. ( 28339643 )
2017
44
A Multimodal Approach for Myofascial Pain Syndrome: A Prospective Study. ( 28739020 )
2017
45
Elevations of Ventricular Lactate Levels Occur in Both Chronic Fatigue Syndrome and Fibromyalgia. ( 29308330 )
2017
46
Effect of dry needling on myofascial pain syndrome of the quadratus femoris: A case report. ( 28922048 )
2017
47
Effects of active/passive interventions on pain, anxiety, and quality of life in women with fibromyalgia: Randomized controlled pilot trial. ( 26882533 )
2017
48
The role of oxidative stress in the relation between fibromyalgia and obstructive sleep apnea syndrome. ( 28121361 )
2017
49
Comparison of the Efficiency of Ultrasound-Guided Injections of the Rhomboid Major and Trapezius Muscles in Myofascial Pain Syndrome: A Prospective Randomized Controlled Double-blind Study. ( 29048132 )
2017
50
Differential pain modulation in patients with peripheral neuropathic pain and fibromyalgia. ( 29913862 )
2017
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Variations for Fibromyalgia

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Expression for Fibromyalgia

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Search GEO for disease gene expression data for Fibromyalgia.
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Pathways for Fibromyalgia

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Pathways related to Fibromyalgia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
CREB Pathway 64
Show member pathways
 12.91 GRIN2D HTR2A HTR3A IGF1 IL6
3
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.62 IGF1 IL6 SERPINA1
4
Serotonergic synapse 37
11.49 HTR2A HTR3A SLC6A4
5
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.47 HTR2A HTR3A IL6 SLC6A4
6
Lung fibrosis 1
11.13 IGF1 IL6 SERPINA1
7
Neurotransmitter Clearance In The Synaptic Cleft 66
Show member pathways
 10.78 COMT SLC6A4
8
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 61
10.25 HTR2A HTR3A SLC6A4
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GO Terms for Fibromyalgia

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Cellular components related to Fibromyalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 postsynaptic membrane GO:0045211 8.8 COMT GRIN2D HTR3A

Biological processes related to Fibromyalgia according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.73 CRH HTR2A IGF1 IL6
2 cellular protein metabolic process GO:0044267 9.67 IGF1 IL6 SERPINA1
3 positive regulation of gene expression GO:0010628 9.62 CRH IGF1 IL6 SLC6A4
4 response to cocaine GO:0042220 9.52 CRH HTR3A
5 acute-phase response GO:0006953 9.51 IL6 SERPINA1
6 phosphatidylinositol 3-kinase signaling GO:0014065 9.48 HTR2A IGF1
7 regulation of sensory perception of pain GO:0051930 9.46 COMT GRIN2D
8 chemical synaptic transmission GO:0007268 9.46 CRH HTR2A HTR3A NPY
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.43 HTR2A IGF1 IL6
10 adrenal gland development GO:0030325 9.4 CRH TSPO
11 positive regulation of glycolytic process GO:0045821 9.37 HTR2A IGF1
12 response to drug GO:0042493 9.35 COMT CRH HTR2A SLC6A4 TSPO
13 response to pain GO:0048265 8.8 COMT CRH TSPO

Molecular functions related to Fibromyalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuropeptide hormone activity GO:0005184 9.16 CRH NPY
2 hormone activity GO:0005179 9.13 CRH IGF1 NPY
3 serotonin binding GO:0051378 8.62 HTR2A HTR3A
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Sources for Fibromyalgia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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