Aliases & Classifications for Fibromyalgia

MalaCards integrated aliases for Fibromyalgia:

Name: Fibromyalgia 12 74 43 36 54 42 3 44 15 62 17 71 32
Fibromyalgia-Fibromyositis Syndrome 43
Diffuse Myofascial Pain Syndrome 43
Myofascial Pain Syndromes 71
Myofascial Pain Syndrome 43
Fibromyalgia Syndrome 43
Fibromyositis 43
Fibrositis 43
Fms 43


External Ids:

Disease Ontology 12 DOID:631
KEGG 36 H01636
MeSH 44 D005356
NCIt 50 C87497
SNOMED-CT 67 1304004
ICD10 32 M79.7
UMLS 71 C0016053 C0027073

Summaries for Fibromyalgia

MedlinePlus : 42 What is fibromyalgia? Fibromyalgia is chronic condition that causes pain all over the body, fatigue, and other symptoms. People with fibromyalgia may be more sensitive to pain than people who don't have it. This is called abnormal pain perception processing. What causes fibromyalgia? The exact cause of fibromyalgia is unknown. Researchers think that certain things might contribute to its cause: Stressful or traumatic events, such as car accidents Repetitive injuries Illnesses such as viral infections Sometimes, fibromyalgia can develop on its own. It can run in families, so genes may play a role in the cause. Who is at risk for fibromyalgia? Anyone can get fibromyalgia, but it is more common in Women; they are twice as likely to have fibromyalgia Middle-aged people People with certain diseases, such as lupus, rheumatoid arthritis, or ankylosing spondylitis People who have a family member with fibromyalgia What are the symptoms of fibromyalgia? Common symptoms of fibromyalgia include Pain and stiffness all over the body Fatigue and tiredness Problems with thinking, memory, and concentration (sometimes called "fibro fog") Depression and anxiety Headaches, including migraines Irritable bowel syndrome Numbness or tingling in the hands and feet Pain in the face or jaw, including disorders of the jaw know as temporomandibular joint syndrome (TMJ) Sleep problems How is fibromyalgia diagnosed? Fibromyalgia can be hard to diagnose. It sometimes takes visits to several different health care providers to get a diagnosis. One problem is that there isn't a specific test for it. And the main symptoms, pain and fatigue, are common in many other conditions. Health care providers have to rule out other causes of the symptoms before making a diagnosis of fibromyalgia. This is called making a differential diagnosis. To make a diagnosis, your health care provider Will take your medical history and ask detailed questions about your symptoms Will do a physical exam May do x-rays and blood tests to rule out other conditions Will consider the guidelines for diagnosing fibromyalgia, which include A history of widespread pain lasting more than 3 months Physical symptoms including fatigue, waking unrefreshed, and cognitive (memory or thought) problems The number of areas throughout the body in which you had pain in the past week What are the treatments for fibromyalgia? Not all health care providers are familiar with fibromyalgia and its treatment. You should see a doctor or team of health care providers who specialize in the treatment of fibromyalgia. Fibromyalgia is treated with a combination of treatments, which may include medicines, lifestyle changes, talk therapy, and complementary therapies: Medicines Over-the-counter pain relievers Prescription medicines that were specifically approved to treat fibromyalgia Prescription pain medicines Certain antidepressants, which may help with pain or sleep problems Lifestyle changes Getting enough sleep Getting regular physical activity. If you have not already been active, start slowly and gradually increase how much activity you get. You may want to see a physical therapist, who can help you create a plan that is right for you. Learning how to manage stress Eating a healthy diet Learning to pace yourself. If you do too much, it can make your symptoms worse. So you need to learn to balance being active with your need for rest. Talk therapy, such as cognitive behavioral therapy (CBT), can help you learn strategies to deal with pain, stress, and negative thoughts. If you also have depression along with your fibromyalgia, talk therapy can help with that too. Complementary therapies have helped some people with the symptoms of fibromyalgia. But researchers need to do more studies to show which ones are effective. You could consider trying them, but you should check with your health care provider first. These therapies include Massage therapy Movement therapies Chiropractic therapy Acupuncture

MalaCards based summary : Fibromyalgia, also known as fibromyalgia-fibromyositis syndrome, is related to interstitial cystitis and chronic pain, and has symptoms including muscle weakness, fatigue and myoclonus. An important gene associated with Fibromyalgia is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways are Peptide ligand-binding receptors and cAMP signaling pathway. The drugs Gabapentin and Etoricoxib have been mentioned in the context of this disorder. Affiliated tissues include liver, cortex and pituitary, and related phenotypes are behavior/neurological and homeostasis/metabolism

MedlinePlus Genetics : 43 Fibromyalgia is a common condition characterized by long-lasting (chronic) pain affecting many areas of the body. The pain is associated with tenderness that occurs with touch or pressure on the muscles, joints, or skin. Some affected individuals also report numbness, tingling, or a burning sensation (paresthesia) in the arms and legs.Other signs and symptoms of fibromyalgia include excessive tiredness (exhaustion); sleep problems, such as waking up feeling unrefreshed; and problems with memory or thinking clearly. People with fibromyalgia often report additional types of pain, including headaches, back and neck pain, sore throat, pain or clicking in the jaw (temporomandibular joint dysfunction), and stomach pain or digestive disorders such as irritable bowel syndrome. They have an increased likelihood of developing mood or psychiatric disorders including depression, anxiety, and obsessive-compulsive disorder. However, many people with fibromyalgia do not have a mental health condition.The major signs and symptoms of fibromyalgia can occur by themselves or together with another chronic pain condition such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, or systemic lupus erythematosus.

CDC : 3 Fibromyalgia (fi·bro·my·al·gi·a) is a condition that causes pain all over the body (also referred to as widespread pain), sleep problems, fatigue, and often emotional and mental distress. People with fibromyalgia may be more sensitive to pain than people without fibromyalgia. This is called abnormal pain perception processing. Fibromyalgia affects about 4 million US adults, about 2% of the adult population. The cause of fibromyalgia is not known, but it can be effectively treated and managed.

KEGG : 36 Fibromyalgia is a common and chronic pain disorder that predominantly affects women. It belongs to the group of rheumatic disorders of the soft tissues, and is characterised by widespread chronic pain, cognitive and affective disturbances and fatigue. The etiology and pathogenesis of fibromyalgia is uncertain. Genetic studies suggest an association with polymorphisms in serotonergic, dopaminergic, and catecholaminergic pathways involved in pain transmission and modulation. The disease is likely expressed in the presence of environmental trigger, which lead to expression of multiple genes that amplify pain perception in the pain processing pathway. Although there is no ultimate cure for fibromyalgia, some medications can alleviate symptoms of the disease.

PubMed Health : 62 About fibromyalgia: Fibromyalgia (also known as fibromyalgia syndrome or FMS) is a chronic condition that causes pain in various parts of the body. The pain may be felt in the skin, muscles and joints. Other typical symptoms include sleep problems, exhaustion and trouble concentrating. Although fibromyalgia has been recognized as an illness for 30 years now, people who have it are still sometimes made to feel like it’s all in their head. Part of the reason for this is that not many people are aware of fibromyalgia, and healthy people find it hard to understand. This often makes it even harder to live with the condition. Sometimes people who have fibromyalgia are told that the pain can’t be treated. But research has shown that there are indeed treatments that can relieve the typical symptoms. And many people learn to cope better with the pain over time. They find out what activities they can handle – and when to take things easier. It’s good to know that fibromyalgia isn’t a dangerous condition. It doesn’t affect people’s organs or life expectancy.

Wikipedia : 74 Fibromyalgia (FM) is a medical condition characterized by chronic widespread pain and a heightened pain... more...

Related Diseases for Fibromyalgia

Diseases related to Fibromyalgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1062)
# Related Disease Score Top Affiliating Genes
1 interstitial cystitis 32.2 TACR1 IL6 CXCL8 BDNF
2 chronic pain 32.2 PNOC OPRM1 COMT
3 pre-eclampsia 31.4 TNF IL6 IGF1 CXCL8 CRP CRH
4 back pain 31.3 IL6 COMT
5 headache 31.3 SLC6A4 HTR3A HTR2A COMT
6 depression 31.3 SLC6A4 HTR3A HTR2A CRH BDNF
7 alexithymia 31.2 SLC6A4 IL6 CRP COMT
8 spondylitis 31.1 TNF IL6 CRP
9 chronic fatigue syndrome 31.0 TNF SLC6A4 POMC IL6 IGF1 HTR2A
10 spondyloarthropathy 1 31.0 TNF IL6 CRP
11 sexual disorder 31.0 SLC6A4 POMC IGF1 HTR2A BDNF
12 osteoarthritis 30.9 TNF IL6 CXCL8 CRP
13 acute stress disorder 30.9 SLC6A4 POMC IL6 CRP CRH BDNF
14 somatization disorder 30.8 SLC6A4 POMC IL6 CRH COMT
15 lyme disease 30.7 TNF IL6 CRP
16 personality disorder 30.7 SLC6A4 HTR3A HTR2A CRH COMT BDNF
17 obsessive-compulsive personality disorder 30.7 SLC6A4 HTR2A COMT
18 paine syndrome 30.7 TNF TACR1 SLC6A4 PNOC OPRM1 IL6
19 cystitis 30.6 TNF TACR1 IL6 CXCL8 CRP BDNF
20 irritable bowel syndrome 30.6 TNF SLC6A4 POMC IL6 HTR3A HTR2A
21 post-traumatic stress disorder 30.6 SLC6A4 PREP POMC HTR2A CRP CRH
22 hypochondriasis 30.6 SLC6A4 POMC HTR2A BDNF
23 restless legs syndrome 30.6 SLC6A4 SERPINA1 POMC COMT
24 mental depression 30.6 TNF SLC6A4 POMC IL6 HTR2A CRP
25 temporal arteritis 30.6 TNF IL6 CRP
26 brucellosis 30.5 TNF IL6 CXCL8 CRP
27 synovitis 30.5 TNF IL6 CXCL8 CRP
28 placenta disease 30.5 TNF IL6 CXCL8 CRP
29 juvenile rheumatoid arthritis 30.5 TNF IL6 CXCL8 CRP
30 familial mediterranean fever 30.4 TNF IL6 CXCL8 CRP
31 mood disorder 30.4 TACR1 SLC6A4 POMC NPY IL6 HTR3A
32 dry eye syndrome 30.4 TNF IL6 BDNF
33 pustulosis of palm and sole 30.4 TNF CXCL8 CRP
34 thyroiditis 30.4 TNF IL6 CRP
35 complex regional pain syndrome 30.4 TNF TACR1 POMC NPY IL6 CXCL8
36 relapsing-remitting multiple sclerosis 30.4 TNF IL6 CXCL8 BDNF
37 sleep apnea 30.4 TNF SLC6A4 IL6 IGF1 HTR2A CXCL8
38 fasciitis 30.3 TNF IL6 CXCL8
39 serotonin syndrome 30.3 SLC6A4 HTR3A HTR2A
40 somatoform disorder 30.3 TACR1 SLC6A4 OPRM1 IL6 CRH COMT
41 panniculitis 30.3 TNF SERPINA1 CRP
42 urethral syndrome 30.3 TNF IL6 CXCL8
43 bruxism 30.3 SLC6A4 HTR2A COMT
44 atherosclerosis susceptibility 30.3 TNF IL6 CXCL8 CRP
45 borderline personality disorder 30.3 SLC6A4 HTR3A HTR2A CRH COMT BDNF
46 constipation 30.3 TACR1 SLC6A4 OPRM1 NPY IL6 HTR3A
47 exanthem 30.3 TNF IL6 CXCL8 CRP
48 bipolar i disorder 30.3 SLC6A4 HTR2A COMT BDNF
49 agoraphobia 30.2 SLC6A4 HTR2A CRH COMT BDNF
50 conversion disorder 30.2 HTR2A CRH COMT BDNF

Graphical network of the top 20 diseases related to Fibromyalgia:

Diseases related to Fibromyalgia

Symptoms & Phenotypes for Fibromyalgia

UMLS symptoms related to Fibromyalgia:

muscle weakness, fatigue, myoclonus, back pain, myalgia, torticollis, pain, chronic pain, sciatica, muscle cramp, muscle rigidity, muscle spasticity, myofascial trigger point pain

MGI Mouse Phenotypes related to Fibromyalgia:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.34 BDNF COMT CRH GRIN2D HTR2A HTR3A
2 homeostasis/metabolism MP:0005376 10.22 BDNF COMT CRH CRP GRIN2D HTR3A
3 endocrine/exocrine gland MP:0005379 10.18 BDNF COMT CRH HTR2A HTR3A IGF1
4 growth/size/body region MP:0005378 10.18 BDNF CRH GRIN2D HTR3A IGF1 IL6
5 adipose tissue MP:0005375 10.11 CRH GRIN2D IGF1 IL6 NPY OPRM1
6 immune system MP:0005387 10.03 COMT CRH CRP HTR3A IGF1 IL6
7 integument MP:0010771 9.93 BDNF CRH GRIN2D HTR3A IGF1 IL6
8 nervous system MP:0003631 9.8 BDNF COMT CRH GRIN2D HTR3A IGF1
9 renal/urinary system MP:0005367 9.23 COMT CRH HTR3A IGF1 IL6 NPY

Drugs & Therapeutics for Fibromyalgia

PubMed Health treatment related to Fibromyalgia: 62

Many people who have fibromyalgia avoid physical activity for fear of making the pain worse or overdoing it. But research has shown that exercise and gentle sports (e.g. cycling or Nordic walking) can improve their wellbeing, strengthen their body and relieve the pain somewhat. So they are an important part of the treatment . Certain medications have been proven to greatly reduce fibromyalgia pain in some people. These include amitriptyline , duloxetine , milnacipran and pregabalin . They all influence certain chemical messengers that also affect how we feel pain. These drugs were originally developed for the treatment of depression or epilepsy . When used in the treatment of fibromyalgia, though, they aren’t used for their antidepressant or anti-epileptic effects. Conventional painkillers such as diclofenac , ibuprofen or acetaminophen (paracetamol) generally aren’t recommended for the treatment of fibromyalgia. Many people with fibromyalgia find certain types of physical therapy to be pleasant, especially resting and/or moving in warm water. Some also say that going to the sauna or having gentle massages help. Multimodal pain management can be a good idea, particularly if the fibromyalgia pain is strong. This approach combines movement, relaxation and pain management techniques used in cognitive behavioral therapy (CBT). CBT and other psychological treatments can help people to cope better with pain and other symptoms in everyday life. Medication can be used as well. If someone also has other illnesses such as arthritis or psychological problems such as depression , it’s important to treat those conditions too.

Drugs for Fibromyalgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 318)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
Perphenazine Approved Phase 4 58-39-9 4748
Modafinil Approved, Investigational Phase 4 68693-11-8 4236
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
Sodium citrate Approved, Investigational Phase 4 68-04-2
Histamine Approved, Investigational Phase 4 51-45-6, 75614-87-8 774
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
tannic acid Approved Phase 4 1401-55-4
Fluoxetine Approved, Vet_approved Phase 4 54910-89-3 3386
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
Flunarizine Approved Phase 4 52468-60-7 941361
Acetaminophen Approved Phase 4 103-90-2 1983
Amitriptyline Approved Phase 4 50-48-6 2160
Citalopram Approved Phase 4 59729-33-8 2771
Ketorolac Approved Phase 4 74103-06-3, 66635-83-4 3826
Ibuprofen Approved Phase 4 15687-27-1 3672
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
Ethanol Approved Phase 4 64-17-5 702
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 4 7487-88-9 24083
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
Suvorexant Approved, Investigational Phase 4 1030377-33-3
Promethazine Approved, Investigational Phase 4 60-87-7 4927
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
Glutamic acid Approved, Nutraceutical Phase 4 56-86-0 33032
Citric acid Approved, Nutraceutical, Vet_approved Phase 4 77-92-9 311
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 68-26-8, 11103-57-4 445354
37 Cyclooxygenase 2 Inhibitors Phase 4
38 Antipsychotic Agents Phase 4
39 Antiemetics Phase 4
40 Quetiapine Fumarate Phase 4 111974-72-2
41 Central Nervous System Stimulants Phase 4
42 Citrate Phase 4
43 Anesthetics, Intravenous Phase 4
44 Anesthetics, General Phase 4
45 Cytochrome P-450 Enzyme Inhibitors Phase 4
46 Histamine Antagonists Phase 4
Histamine Phosphate Phase 4 51-74-1 65513
48 Histamine H1 Antagonists Phase 4
49 Excitatory Amino Acid Antagonists Phase 4
50 Anesthetics, Dissociative Phase 4

Interventional clinical trials:

(show top 50) (show all 859)
# Name Status NCT ID Phase Drugs
1 An Eight Week, Double-Blind Efficacy Study of Cyclobenzaprine ER (Amrix TM) Augmentation to Alleviate Fibromyalgia Fatigue and Muscle Pain Unknown status NCT01041495 Phase 4 cyclobenzaprine ER (AMRIX);placebo
2 Study Proposal - A Randomized Double-blinded Study Comparing Adding Etoricoxib Versus Placebo to Female Patients With Fibromyalgia-analysis of Organic and Psychiatric Measures Unknown status NCT00755521 Phase 4 etoricoxib
3 Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? A Randomized, Double-blinded, Placebo-controlled, Crossover Study. Unknown status NCT02806440 Phase 4 Low dose naltrexone;Placebo
4 Open Label Trial Evaluating the Efficacy of Apremilast for the Treatment of Frontal Fibrosing Alopecia Unknown status NCT03422640 Phase 4 Apremilast
5 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
6 A Randomized Controlled Trial Comparing the Efficay and Tolerability of Ai Chi Versus Stretching in Fibromyalgia Management: a Six Months Study Completed NCT00600574 Phase 4
7 The Study of Heart Rate Variability in Patients With Fibromyalgia - Effects of Strengthening Exercises Completed NCT02004405 Phase 4
8 Pool-based Exercise in Fibromyalgia Management: a Prospective Randomized Comparison Between Stretching and Ai Chi Completed NCT00550641 Phase 4
9 Fixed Versus Flexible Dosing of Pregabalin in Patients With Fibromyalgia Completed NCT01226667 Phase 4 Pregabalin
10 A Randomized, Pilot Clinical Trial to Assess the Comparative Efficacy and Tolerability of Quetiapine XR Versus Amitriptyline for the Treatment of Patients With Fibromyalgia Completed NCT00766350 Phase 4 amitriptyline;quetiapine
11 An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue Completed NCT00678691 Phase 4 armodafinil;placebo
12 Open Label Trial Concerning the Effectiveness of Trazodone in the Treatment of Fibromyalgia (Phase I) and Its Augmentation With Pregabalin in Trazodone Partial Responders (Phase II) Completed NCT00791739 Phase 4 trazodone, pregabalin
13 The Efficacy of Topical Thiocolchicoside in Cervical Myofascial Pain Syndrome: Triple-Arm, Single-Blind, Randomized, Prospective, Phase IV Clinical Study Completed NCT00272532 Phase 4 Thiocolchicoside
14 Treatment of Myofascial Pain Syndrome With Lidocaine Injection and Physical Therapy, Alone or in Combination: a Single-blind, Randomized, Controlled Clinical Trial. Completed NCT01250184 Phase 4 Lidocaine injection
15 Paroxetine-CR (Paxil-CR) in the Treatment of Patients With Fibromyalgia Syndrome: A Randomized, Double Blind, Parallel Group, Flexible Dose, Placebo Controlled Trial. Completed NCT00610610 Phase 4 Paroxetine CR;Placebo
16 A Double Blind, Randomized Placebo Controlled Study of the Efficacy, Safety and Tolerability of Quetiapine Fumarate Sustained Release(Seroquel SRTM) in the Treatment of Major Depression With Comorbid Fibromyalgia Syndrome. Completed NCT00675896 Phase 4 Quetiapine Fumarate Sustained Release;Placebo
17 An Open-Label Pilot Study to Assess Potential Mechanisms for Fibromyalgia in Peripheral Tissue Innervation That Could Predict Therapeutic Responsiveness to Milnacipran Completed NCT01125423 Phase 4 Milnacipran
18 A Pilot Study on the Combined Use of Cognitive Behavioral Therapy (CBT) and Milnacipran Completed NCT01038323 Phase 4 Educational with milnacipran
19 A 6-month, Open-label, Safety Trial Of Pregabalin In Adolescent Patients With Fibromyalgia Completed NCT01020526 Phase 4 pregabalin
20 A 15 Week, Randomized, Double Blind, Parallel-group, Placebo-controlled, Flexible-dose, Safety And Efficacy Study Of Pregabalin In Adolescents (12-17 Years Old) With Fibromyalgia Completed NCT01020474 Phase 4 placebo;pregabalin (Lyrica)
21 Quetiapine Compared With Placebo in the Management of Fibromyalgia Completed NCT01458964 Phase 4 Quetiapine
22 Effects of a 12 Week Milnacipran 200 mg Treatment on Pain Perception and Pain Processing in Fibromyalgia - An Open Label Study Completed NCT01288807 Phase 4 Milnacipram
23 Perception of Discomfort and Psychosocial Difficulties in People With Diagnosis of Fibromyalgia and Predominant Neck Pain Completed NCT02078791 Phase 4 Botox infiltration
24 A Randomized, Double-blind,Placebo-controlled, Two-way Crossover Study to Evaluate the Effect of Milnacipran on Pain Processing and Functional Magnetic Resonance Imaging Activation Patterns in Patients With Fibromyalgia Completed NCT01173055 Phase 4 milnacipran;Placebo
25 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Switch Study to Evaluate the Safety, Tolerability and Efficacy of Milnacipran in Patients With an Inadequate Response to Duloxetine for the Treatment of Fibromyalgia Completed NCT01077375 Phase 4 Placebo;Milnacipran
26 A Multicenter, Randomized, Double-blind, Placebo-Controlled Discontinuation Study of the Durability of Effect of Milnacipran for the Treatment of Fibromyalgia in Patients Receiving Long-term Milnacipran Treatment Completed NCT01014585 Phase 4 Placebo;Milnacipran
27 Eszopiclone in the Treatment of Insomnia and Associated Symptoms of Fibromyalgia Completed NCT00392041 Phase 4 Eszopiclone;placebo
28 Ultracet (Tramadol HCL [37.5 mg]/Acetaminophen [325 mg]) Combination Tablets in the Treatment of the Pain of Fibromyalgia Completed NCT00766675 Phase 4 Tramadol hydrochloride;Acetaminophen
29 Effectiveness of Strengthening Exercises Using the Swiss Ball for Patients With Fibromyalgia: a Randomized Controlled Trial Completed NCT02063750 Phase 4
30 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed NCT01234675 Phase 4 Milnacipran;Placebo
31 Combining N-of-1 Trials to Assess Fibromyalgia Therapies Completed NCT00000428 Phase 4 Amitriptyline;Amitriptyline plus Fluoxitine
32 Flexible Dosed Duloxetine Versus Placebo in the Treatment of Fibromyalgia Completed NCT00673452 Phase 4 duloxetine hydrochloride;placebo
33 A Pilot Study on the Use of Nociceptive Flexion Reflex for Fibromyalgia Completed NCT00965601 Phase 4
34 Quetiapine (Seroquel XR) for the Treatment of Fibromyalgia: a Clinical and Mechanistic Pilot Study Completed NCT00983320 Phase 4 quetiapine;placebo
35 A Randomized, Double-Blind Comparison of Duloxetine 30 mg QD and Placebo in Adult Patients With Fibromyalgia Completed NCT00965081 Phase 4 Duloxetine;Placebo
36 Randomized, Double-blind, Placebo-controlled Trial to Measure the Efficacy and Safety of Vitamin D3 in Patients With Fibromyalgia. Completed NCT03369379 Phase 4 D3 Vitamin
37 Ambulatory Infusions of Lidocaine and Ketamine for Management of Chronic Pain: an Observational Prospective Study Completed NCT04123652 Phase 4 Lidocaine Hydrochloride 2% Intravenous Solution, DIN 02421992
38 Probe Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
39 The Serotonin Receptor Type 3 Antagonist Granisetron as a New Treatment Approach for Patients With Chronic Myofascial Pain in the Orofacial Muscles Completed NCT02230371 Phase 4 Granisetron;Control (placebo)
40 Plasma Rich in Growth Factors Effectiveness for Myofascial Pain Treatment in Masticatory Muscles: a Randomized Controlled Clinical Trial Completed NCT04040309 Phase 4 Lidocaine injection
41 Neurologic Signatures of Chronic Pain Disorders Completed NCT02747940 Phase 4 flunarizine and/or pregabalin
42 A Randomized, Single-dose, Parallel-group Study to Evaluate the Pharmacokinetic Profiles of Two Formulation of Pregabalin in Healthy Volunteers Under Fasting Conditions Completed NCT03712475 Phase 4 Pregabalin
43 Trigger Point Injection for Myofascial Pain Syndrome in the Low Back (T-PIMPS): A Randomized Controlled Trial. Recruiting NCT04704297 Phase 4 Treatment of Myofascial Pain Syndrome in the low back. This intervention will be based on outcomes of the medications listed below.;Evaluation of functional ability using a patient centered functional score known as the Modified Oswestry Disability Index (MODI). The intervention will be based on outcomes of medications below.;Following up with participants 60-72 hours after treatment in the Emergency Department. This intervention will be based on outcomes of the medications listed below.
44 Efficacy and Tolerability of Micronized and Ultramicronized Palmitoylethanolamide in Fibromyalgia Patients: A Double-blind, Randomized, Placebo-controlled Clinical Trial Recruiting NCT04488926 Phase 4 Standard Therapy;Rescue Drug
45 Determining Optimal Treatment Sequences in Anxious Depression (DOTS-AD) Recruiting NCT04245748 Phase 4 Escitalopram;Duloxetine
46 Anti-CGRP Neutralizing Antibody for Modulation of Neurogenic Inflammation in Trigeminal and Glossopharyngeal Pain Associated With Small Fiber Neuropathy/Fibromyalgia Recruiting NCT04158752 Phase 4 Galcanezumab
47 Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty: A Double-blinded Randomized Control Trial Active, not recruiting NCT03271151 Phase 4 Cymbalta
48 Magnesium Sulphate Injection in Treatment of Myofascial Trigger Points in Masseter Muscle Not yet recruiting NCT04742140 Phase 4 Magnesium sulfate;Saline
49 Effectiveness, Cost-utility and Neurobiological Effects of Low-dose Naltrexone in Patients With Fibromyalgia (INNOVA Project) Not yet recruiting NCT04739995 Phase 4 Low-dose naltrexone
50 Local Injection of Lidocaine Versus Ischemic Compression in Treatment of Woman With Chronic Pelvic Pain Caused by Abdominal Myofascial Pain Syndrome: Randomized Clinical Trial. Terminated NCT00628355 Phase 4 lidocaine

Search NIH Clinical Center for Fibromyalgia

Cochrane evidence based reviews: fibromyalgia

Genetic Tests for Fibromyalgia

Anatomical Context for Fibromyalgia

MalaCards organs/tissues related to Fibromyalgia:

Liver, Cortex, Pituitary, Brain, Thyroid, Skeletal Muscle, Spinal Cord

Publications for Fibromyalgia

Articles related to Fibromyalgia:

(show top 50) (show all 10695)
# Title Authors PMID Year
Augmentation of EMDR with multifocal transcranial current stimulation (MtCS) in the treatment of fibromyalgia: study protocol of a double-blind randomized controlled exploratory and pragmatic trial. 61 42
33514408 2021
Effects of neuro-adaptive electrostimulation therapy on pain and disability in fibromyalgia: A prospective, randomized, double-blind study. 61 42
33371148 2020
Clustering fibromyalgia patients: A combination of psychosocial and somatic factors leads to resilient coping in a subgroup of fibromyalgia patients. 42 61
33370324 2020
Pathophysiology of fibromyalgia: a comparison with the tension-type headache, a localized pain syndrome. 54 61
20398011 2010
Genetic influences on the dynamics of pain and affect in fibromyalgia. 61 54
20230086 2010
Candidate-gene approach in fibromyalgia syndrome: association analysis of the genes encoding substance P receptor, dopamine transporter and alpha1-antitrypsin. 54 61
20074437 2009
Autonomic dysfunction and neuropeptide Y in fibromyalgia. 61 54
20074444 2009
The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia. 61 54
20074440 2009
Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. 61 54
18196244 2008
Cerebrospinal fluid corticotropin-releasing factor concentration is associated with pain but not fatigue symptoms in patients with fibromyalgia. 54 61
16936702 2006
Corticotropin releasing factor in urine--a possible biochemical marker of fibromyalgia. Responses to massage and guided relaxation. 54 61
16716515 2006
Increased expression of N-methyl-D-aspartate receptor subunit 2D in the skin of patients with fibromyalgia. 54 61
16583480 2006
Alteration of serotonin transporter density and activity in fibromyalgia. 61 54
16790074 2006
alpha1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia. 54 61
15694694 2005
Alpha1-antitrypsin replacement therapy controls fibromyalgia symptoms in 2 patients with PI ZZ alpha1-antitrypsin deficiency. 54 61
15468381 2004
Increase in peripheral benzodiazepine receptors on monocytes in fibromyalgia. 61 54
15252208 2004
Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. 61 54
15293096 2004
Open trial of mirtazapine in patients with fibromyalgia. 61 54
15467973 2004
Efficacy and tolerability of intravenous tropisetron in the treatment of fibromyalgia. 54 61
15370724 2004
Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5- HTTLPR) polymorphism, and relationship to anxiety-related personality traits. 54 61
11920428 2002
Neuroendocrine and immune aspects of fibromyalgia. 61 54
11543693 2001
Responses of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis to interleukin-6: a pilot study in fibromyalgia. 61 54
10765933 2000
Efficacy and tolerability of tropisetron in primary fibromyalgia--a highly selective and competitive 5-HT3 receptor antagonist. German Fibromyalgia Study Group. 54 61
11028832 2000
Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. 54 61
10555044 1999
Lower serum activity of prolyl endopeptidase in fibromyalgia is related to severity of depressive symptoms and pressure hyperalgesia. 61 54
9723150 1998
Plasma levels on nociceptin in female fibromyalgia syndrome patients. 61 54
10025089 1998
Pathogenetic aspects of responsiveness to ondansetron (5-hydroxytryptamine type 3 receptor antagonist) in patients with primary fibromyalgia syndrome--a preliminary study. 61 54
8856622 1996
The 5-HT3 blockers in the treatment of the primary fibromyalgia syndrome: a 10-day open study with Tropisetron at a low dose. 54 61
9088121 1996
Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. 54 61
7980669 1994
Blood pressure as a predictor of everyday cognitive function in aging adults with and without fibromyalgia. 61
32339069 2021
Identifying biopsychosocial factors that impact decompressive laminectomy outcomes in veterans with lumbar spinal stenosis: a prospective cohort study. 61
32925594 2021
Decreased sleep quality in patients with systemic lupus erythematosus: a meta-analysis. 61
32748069 2021
Fatigue and its correlates in Indian patients with systemic lupus erythematosus. 61
33033858 2021
Patient Factors Associated With Opioid Consumption in the Month Following Major Surgery. 61
31389832 2021
Altered regulation of negative affect in patients with fibromyalgia: A diary study. 61
33259659 2021
Fibromyalgia: Recognition and Management in the Primary Care Office. 61
33589103 2021
Two sides on the fibromyalgia coin: physical pain and social pain (invalidation). 61
32772267 2021
Infographic. Effects of exercise in patients with fibromyalgia: an umbrella review. 61
32796018 2021
Idiopathic myalgic pain (fibromyalgia): supportive management and prevention with Pycnogenol®. 61
33541059 2021
Inhibitors of angiotensin I converting enzyme potentiate fibromyalgia-like pain symptoms via kinin receptors in mice. 61
33476653 2021
Clinical, psychological and quality of life differences in fibromyalgia patients from secondary and tertiary healthcare. 61
33170991 2021
Memory gaps, lost words and crucial mistakes - Men's experiences of cognitive difficulties in fibromyalgia. 61
30587007 2021
Functional characterization of nociceptive mechanisms involved in fibromyalgia and electroacupuncture. 61
33422528 2021
Neural effects of placebo analgesia in fibromyalgia patients and healthy individuals. 61
32925593 2021
Sexual Difficulties in the Population with Musculoskeletal Chronic Pain: A Systematic Review. 61
33576430 2021
Efficacy and safety of weekly vitamin D3 in patients with fibromyalgia: 12-week, double-blind, randomized, controlled placebo trial. 61
33570701 2021
Evaluation of a Hyperbaric Oxygen Therapy Intervention in Individuals with Fibromyalgia. 61
33594439 2021
Rome IV Functional Gastrointestinal Disorders and Health Impairment in Subjects With Hypermobility Spectrum Disorders or Hypermobile Ehlers-Danlos Syndrome. 61
32109633 2021
Comorbid Conditions, Mental Health and Cognitive Functions in Adults with Fibromyalgia. 61
32589109 2021
Co-occurrence of immune-mediated conditions and endometriosis among adolescents and adult women. 61
33583078 2021

Variations for Fibromyalgia

Expression for Fibromyalgia

Search GEO for disease gene expression data for Fibromyalgia.

Pathways for Fibromyalgia

Pathways related to Fibromyalgia according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
6 11.67 POMC IL6 CXCL8
7 11.62 TNF IL6 CXCL8
8 11.57 TNF POMC NPY
Show member pathways
11.51 TNF IL6 CXCL8
10 11.44 TNF IL6 CXCL8
12 11.37 TNF IL6 CXCL8
13 11.34 TNF IL6 CXCL8
14 11.29 TNF IL6 IGF1
16 11.03 SLC6A4 HTR3A HTR2A
17 10.74 TNF IL6 CXCL8 CRP
18 10.37 POMC CRH

GO Terms for Fibromyalgia

Cellular components related to Fibromyalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 TNF SERPINA1 POMC PNOC NPY IL6
2 synapse GO:0045202 9.87 SLC6A4 PNOC NPY HTR3A HTR2A GRIN2D
3 extracellular space GO:0005615 9.85 TNF SERPINA1 POMC NPY IL6 IGF1
4 dendrite GO:0030425 9.8 PNOC OPRM1 HTR2A COMT BDNF
5 axon GO:0030424 9.77 OPRM1 HTR3A HTR2A COMT BDNF
6 integral component of presynaptic membrane GO:0099056 9.26 SLC6A4 OPRM1 HTR3A HTR2A
7 integral component of postsynaptic membrane GO:0099055 8.92 SLC6A4 OPRM1 HTR3A HTR2A

Biological processes related to Fibromyalgia according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.06 TACR1 POMC PNOC OPRM1 NPY HTR2A
2 signal transduction GO:0007165 10 TACR1 POMC PNOC OPRM1 IL6 IGF1
3 response to drug GO:0042493 9.91 TSPO SLC6A4 HTR2A CRH COMT
4 cytokine-mediated signaling pathway GO:0019221 9.89 TNF POMC OPRM1 IL6 CXCL8
5 cellular response to lipopolysaccharide GO:0071222 9.86 TSPO TNF IL6 CXCL8
6 inflammatory response GO:0006954 9.85 TNF TACR1 IL6 CXCL8 CRP CRH
7 memory GO:0007613 9.8 SLC6A4 HTR2A BDNF
8 chemical synaptic transmission GO:0007268 9.8 PNOC NPY HTR3A HTR2A CRH
9 negative regulation of tumor necrosis factor production GO:0032720 9.79 TSPO POMC IGF1
10 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.79 TNF IL6 IGF1
11 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.78 OPRM1 NPY HTR2A
12 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.77 TACR1 OPRM1 HTR2A
13 excitatory postsynaptic potential GO:0060079 9.77 OPRM1 HTR3A GRIN2D
14 positive regulation of smooth muscle cell proliferation GO:0048661 9.76 TNF IL6 IGF1
15 neuropeptide signaling pathway GO:0007218 9.73 POMC PNOC OPRM1 NPY
16 response to cocaine GO:0042220 9.72 OPRM1 HTR3A CRH
17 acute-phase response GO:0006953 9.7 SERPINA1 IL6 CRP
18 positive regulation of gene expression GO:0010628 9.7 TNF SLC6A4 IL6 IGF1 CXCL8 CRP
19 regulation of sensory perception of pain GO:0051930 9.65 OPRM1 GRIN2D COMT
20 vascular endothelial growth factor production GO:0010573 9.58 TNF IL6
21 serotonin receptor signaling pathway GO:0007210 9.57 HTR3A HTR2A
22 positive regulation of appetite GO:0032100 9.54 OPRM1 NPY
23 positive regulation of glial cell proliferation GO:0060252 9.5 TSPO TNF IL6
24 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP
25 response to pain GO:0048265 8.92 TSPO TACR1 CRH COMT

Molecular functions related to Fibromyalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.46 POMC NPY IGF1 CRH
2 neuropeptide hormone activity GO:0005184 9.13 PNOC NPY CRH
3 serotonin binding GO:0051378 8.8 SLC6A4 HTR3A HTR2A

Sources for Fibromyalgia

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
70 Tocris
72 UMLS via Orphanet
Loading form....