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FMS
MCID: FBR047
MIFTS: 58

Fibromyalgia (FMS)

Categories: Muscle diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Fibromyalgia

About this section

MalaCards integrated aliases for Fibromyalgia:

Name: Fibromyalgia 12 74 25 36 54 42 3 43 15 62 17 71 32
Fibromyalgia-Fibromyositis Syndrome 25
Diffuse Myofascial Pain Syndrome 25
Myofascial Pain Syndromes 71
Myofascial Pain Syndrome 25
Fibromyalgia Syndrome 25
Fibromyositis 25
Fibrositis 25
Fms 25

Classifications:

MalaCards categories:
Anatomical: Muscle diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:631
KEGG 36 H01636
MeSH 43 D005356
NCIt 49 C87497
SNOMED-CT 67 203082005
ICD10 32 M79.7
UMLS 71 C0016053 C0027073
Sources

Summaries for Fibromyalgia

About this section
MedlinePlus : 42 What is fibromyalgia? Fibromyalgia is chronic condition that causes pain all over the body, fatigue, and other symptoms. People with fibromyalgia may be more sensitive to pain than people who don't have it. This is called abnormal pain perception processing. What causes fibromyalgia? The exact cause of fibromyalgia is unknown. Researchers think that certain things might contribute to its cause: Stressful or traumatic events, such as car accidents Repetitive injuries Illnesses such as viral infections Sometimes, fibromyalgia can develop on its own. It can run in families, so genes may play a role in the cause. Who is at risk for fibromyalgia? Anyone can get fibromyalgia, but it is more common in Women; they are twice as likely to have fibromyalgia Middle-aged people People with certain diseases, such as lupus, rheumatoid arthritis, or ankylosing spondylitis People who have a family member with fibromyalgia What are the symptoms of fibromyalgia? Common symptoms of fibromyalgia include Pain and stiffness all over the body Fatigue and tiredness Problems with thinking, memory, and concentration (sometimes called "fibro fog") Depression and anxiety Headaches, including migraines Irritable bowel syndrome Numbness or tingling in the hands and feet Pain in the face or jaw, including disorders of the jaw know as temporomandibular joint syndrome (TMJ) Sleep problems How is fibromyalgia diagnosed? Fibromyalgia can be hard to diagnose. It sometimes takes visits to several different health care providers to get a diagnosis. One problem is that there isn't a specific test for it. And the main symptoms, pain and fatigue, are common in many other conditions. Health care providers have to rule out other causes of the symptoms before making a diagnosis of fibromyalgia. This is called making a differential diagnosis. To make a diagnosis, your health care provider Will take your medical history and ask detailed questions about your symptoms Will do a physical exam May do x-rays and blood tests to rule out other conditions Will consider the guidelines for diagnosing fibromyalgia, which include A history of widespread pain lasting more than 3 months Physical symptoms including fatigue, waking unrefreshed, and cognitive (memory or thought) problems The number of areas throughout the body in which you had pain in the past week What are the treatments for fibromyalgia? Not all health care providers are familiar with fibromyalgia and its treatment. You should see a doctor or team of health care providers who specialize in the treatment of fibromyalgia. Fibromyalgia is treated with a combination of treatments, which may include medicines, lifestyle changes, talk therapy, and complementary therapies: Medicines Over-the-counter pain relievers Prescription medicines that were specifically approved to treat fibromyalgia Prescription pain medicines Certain antidepressants, which may help with pain or sleep problems Lifestyle changes Getting enough sleep Getting regular physical activity. If you have not already been active, start slowly and gradually increase how much activity you get. You may want to see a physical therapist, who can help you create a plan that is right for you. Learning how to manage stress Eating a healthy diet Learning to pace yourself. If you do too much, it can make your symptoms worse. So you need to learn to balance being active with your need for rest. Talk therapy, such as cognitive behavioral therapy (CBT), can help you learn strategies to deal with pain, stress, and negative thoughts. If you also have depression along with your fibromyalgia, talk therapy can help with that too. Complementary therapies have helped some people with the symptoms of fibromyalgia. But researchers need to do more studies to show which ones are effective. You could consider trying them, but you should check with your health care provider first. These therapies include Massage therapy Movement therapies Chiropractic therapy Acupuncture

MalaCards based summary : Fibromyalgia, also known as fibromyalgia-fibromyositis syndrome, is related to pulmonary fibrosis, idiopathic and interstitial cystitis, and has symptoms including muscle weakness, fatigue and myoclonus. An important gene associated with Fibromyalgia is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways are Peptide ligand-binding receptors and cAMP signaling pathway. The drugs Histamine and Etoricoxib have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and skin, and related phenotypes are behavior/neurological and growth/size/body region

Genetics Home Reference : 25 Fibromyalgia is a common condition characterized by long-lasting (chronic) pain affecting many areas of the body. The pain is associated with tenderness that occurs with touch or pressure on the muscles, joints, or skin. Some affected individuals also report numbness, tingling, or a burning sensation (paresthesia) in the arms and legs. Other signs and symptoms of fibromyalgia include excessive tiredness (exhaustion); sleep problems, such as waking up feeling unrefreshed; and problems with memory or thinking clearly. People with fibromyalgia often report additional types of pain, including headaches, back and neck pain, sore throat, pain or clicking in the jaw (temporomandibular joint dysfunction), and stomach pain or digestive disorders such as irritable bowel syndrome. They have an increased likelihood of developing mood or psychiatric disorders including depression, anxiety, and obsessive-compulsive disorder. However, many people with fibromyalgia do not have a mental health condition. The major signs and symptoms of fibromyalgia can occur by themselves or together with another chronic pain condition such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, or systemic lupus erythematosus.

CDC : 3 Fibromyalgia (fi·bro·my·al·gi·a) is a condition that causes pain all over the body (also referred to as widespread pain), sleep problems, fatigue, and often emotional and mental distress. People with fibromyalgia may be more sensitive to pain than people without fibromyalgia. This is called abnormal pain perception processing. Fibromyalgia affects about 4 million US adults, about 2% of the adult population. The cause of fibromyalgia is not known, but it can be effectively treated and managed.

KEGG : 36 Fibromyalgia is a common and chronic pain disorder that predominantly affects women. It belongs to the group of rheumatic disorders of the soft tissues, and is characterised by widespread chronic pain, cognitive and affective disturbances and fatigue. The etiology and pathogenesis of fibromyalgia is uncertain. Genetic studies suggest an association with polymorphisms in serotonergic, dopaminergic, and catecholaminergic pathways involved in pain transmission and modulation. The disease is likely expressed in the presence of environmental trigger, which lead to expression of multiple genes that amplify pain perception in the pain processing pathway. Although there is no ultimate cure for fibromyalgia, some medications can alleviate symptoms of the disease.

PubMed Health : 62 About fibromyalgia: Fibromyalgia (also known as fibromyalgia syndrome or FMS) is a chronic condition that causes pain in various parts of the body. The pain may be felt in the skin, muscles and joints. Other typical symptoms include sleep problems, exhaustion and trouble concentrating. Although fibromyalgia has been recognized as an illness for 30 years now, people who have it are still sometimes made to feel like it’s all in their head. Part of the reason for this is that not many people are aware of fibromyalgia, and healthy people find it hard to understand. This often makes it even harder to live with the condition. Sometimes people who have fibromyalgia are told that the pain can’t be treated. But research has shown that there are indeed treatments that can relieve the typical symptoms. And many people learn to cope better with the pain over time. They find out what activities they can handle – and when to take things easier. It’s good to know that fibromyalgia isn’t a dangerous condition. It doesn’t affect people’s organs or life expectancy.

Wikipedia : 74 Fibromyalgia (FM) is a medical condition characterized by chronic widespread pain and a heightened pain... more...

Sources

Related Diseases for Fibromyalgia

About this section

Diseases related to Fibromyalgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 1290)
# Related Disease Score Top Affiliating Genes
1 pulmonary fibrosis, idiopathic 33.9 TNF SERPINA1 IL6 CXCL8 CRP
2 interstitial cystitis 33.3 TACR1 IL6 CXCL8 BDNF
3 endocarditis 33.0 TNF IL6 CXCL8 CRP
4 sclerosing cholangitis 32.8 TNF IL6 CXCL8
5 infective endocarditis 32.5 TNF IL6 CRP
6 depression 31.8 SLC6A4 HTR2A CRH BDNF
7 pre-eclampsia 31.6 TNF IL6 IGF1 CXCL8 CRP CRH
8 alexithymia 31.5 SLC6A4 IL6 CRP COMT
9 interstitial lung disease 31.5 TNF IL6 CXCL8 CRP
10 paine syndrome 31.3 TACR1 PNOC OPRM1 HTR3A COMT BDNF
11 spondylitis 31.3 TNF IL6 CRP
12 somatization disorder 31.3 SLC6A4 HTR2A CRH
13 lichen planus 31.3 TNF IL6 CXCL8
14 acute stress disorder 31.2 SLC6A4 POMC CRP CRH BDNF
15 sexual disorder 31.2 SLC6A4 POMC IGF1 HTR3A HTR2A
16 osteoarthritis 31.2 TNF IL6 IGF1 CXCL8 CRP
17 sleep disorder 31.1 TNF SLC6A4 POMC IL6 IGF1 HTR2A
18 obstructive jaundice 31.1 TNF IL6 CXCL8 CRP
19 pneumonia 31.1 TNF SERPINA1 IL6 CXCL8 CRP
20 allergic hypersensitivity disease 31.1 TNF TACR1 CXCL8 BDNF
21 pulmonary hypertension 31.1 TNF SLC6A4 IL6 HTR2A CXCL8 CRP
22 arthritis 31.0 TNF OPRM1 IL6 CXCL8 CRP
23 cholangitis 31.0 TNF IL6 CXCL8 CRP
24 bronchiolitis 31.0 TNF IL6 CXCL8 CRP
25 restless legs syndrome 31.0 SLC6A4 POMC HTR3A COMT
26 obsessive-compulsive personality disorder 31.0 SLC6A4 HTR2A COMT
27 lyme disease 30.9 TNF IL6 CRP
28 personality disorder 30.9 SLC6A4 HTR3A HTR2A CRH COMT BDNF
29 dysthymic disorder 30.9 SLC6A4 HTR2A CRH BDNF
30 chronic fatigue syndrome 30.9 TNF SLC6A4 POMC NPY IL6 IGF1
31 temporal arteritis 30.8 TNF IL6 CRP
32 brucellosis 30.8 TNF IL6 CXCL8 CRP
33 placenta disease 30.8 TNF IL6 CXCL8 CRP
34 juvenile arthritis 30.8 IL6 CXCL8 CRP
35 respiratory failure 30.8 TNF SERPINA1 IL6 CXCL8 CRP
36 juvenile rheumatoid arthritis 30.8 TNF IL6 CXCL8 CRP
37 viral hepatitis 30.8 TNF SERPINA1 IL6 CRP
38 familial mediterranean fever 30.8 TNF IL6 CXCL8 CRP
39 synovitis 30.8 TNF IL6 CXCL8 CRP
40 cystitis 30.8 TNF TACR1 IL6 IGF1 CXCL8 CRP
41 pneumoconiosis 30.8 TNF SERPINA1 IL6 CXCL8
42 rosacea 30.8 TNF IL6 CXCL8 CRP
43 bronchiectasis 30.8 TNF SERPINA1 CXCL8 CRP
44 peritonitis 30.7 TNF IL6 CXCL8 CRP
45 hypochondriasis 30.7 SLC6A4 POMC HTR3A HTR2A BDNF
46 bronchiolitis obliterans 30.7 TNF IL6 CXCL8 CRP
47 cryptogenic organizing pneumonia 30.7 TNF CXCL8 CRP
48 dry eye syndrome 30.7 TNF IL6 BDNF
49 conjunctivitis 30.7 TNF IL6 CXCL8
50 complex regional pain syndrome 30.7 TNF TACR1 POMC NPY IL6 CXCL8

Graphical network of the top 20 diseases related to Fibromyalgia:



Diseases related to Fibromyalgia
Sources

Symptoms & Phenotypes for Fibromyalgia

About this section

UMLS symptoms related to Fibromyalgia:


muscle weakness, fatigue, myoclonus, myalgia, back pain, torticollis, pain, chronic pain, sciatica, muscle cramp, muscle rigidity, muscle spasticity, myofascial trigger point pain

MGI Mouse Phenotypes related to Fibromyalgia:

45 (show all 11)
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.38 BDNF COMT CRH GRIN2D HTR2A HTR3A
2 growth/size/body region MP:0005378 10.22 BDNF CRH GRIN2D HTR3A IGF1 IL6
3 homeostasis/metabolism MP:0005376 10.22 BDNF COMT CRH CRP GRIN2D HTR3A
4 endocrine/exocrine gland MP:0005379 10.21 BDNF COMT CRH HTR2A HTR3A IGF1
5 cardiovascular system MP:0005385 10.16 COMT CRP GRIN2D IGF1 IL6 POMC
6 adipose tissue MP:0005375 10.15 CRH GRIN2D IGF1 IL6 NPY OPRM1
7 hematopoietic system MP:0005397 10.11 COMT CRH HTR3A IGF1 IL6 OPRM1
8 immune system MP:0005387 10.03 COMT CRH CRP HTR3A IGF1 IL6
9 integument MP:0010771 9.93 BDNF CRH GRIN2D HTR3A IGF1 IL6
10 nervous system MP:0003631 9.8 BDNF COMT CRH GRIN2D HTR3A IGF1
11 renal/urinary system MP:0005367 9.23 COMT CRH HTR3A IGF1 IL6 NPY
Sources

Drugs & Therapeutics for Fibromyalgia

About this section

PubMed Health treatment related to Fibromyalgia: 62

Many people who have fibromyalgia avoid physical activity for fear of making the pain worse or overdoing it. But research has shown that exercise and gentle sports (e.g. cycling or Nordic walking) can improve their wellbeing, strengthen their body and relieve the pain somewhat. So they are an important part of the treatment . Certain medications have been proven to greatly reduce fibromyalgia pain in some people. These include amitriptyline , duloxetine , milnacipran and pregabalin . They all influence certain chemical messengers that also affect how we feel pain. These drugs were originally developed for the treatment of depression or epilepsy . When used in the treatment of fibromyalgia, though, they aren’t used for their antidepressant or anti-epileptic effects. Conventional painkillers such as diclofenac , ibuprofen or acetaminophen (paracetamol) generally aren’t recommended for the treatment of fibromyalgia. Many people with fibromyalgia find certain types of physical therapy to be pleasant, especially resting and/or moving in warm water. Some also say that going to the sauna or having gentle massages help. Multimodal pain management can be a good idea, particularly if the fibromyalgia pain is strong. This approach combines movement, relaxation and pain management techniques used in cognitive behavioral therapy (CBT). CBT and other psychological treatments can help people to cope better with pain and other symptoms in everyday life. Medication can be used as well. If someone also has other illnesses such as arthritis or psychological problems such as depression , it’s important to treat those conditions too.

Drugs for Fibromyalgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 297)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 4 51-45-6 774
2
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
3
Flunarizine Approved Phase 4 52468-60-7 941361
4
Dinoprostone Approved Phase 4 363-24-6 5280360
5
Amitriptyline Approved Phase 4 50-48-6 2160
6
Perphenazine Approved Phase 4 58-39-9 4748
7
Tramadol Approved, Investigational Phase 4 27203-92-5 33741
8
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
9
Hydrocortisone Approved, Vet_approved Phase 4 50-23-7 5754
10
Hydrocortisone acetate Approved, Vet_approved Phase 4 50-03-3
11
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
12
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
13
Citalopram Approved Phase 4 59729-33-8 2771
14
Ketamine Approved, Vet_approved Phase 4 6740-88-1 3821
15
Clonazepam Approved, Illicit Phase 4 1622-61-3 2802
16
Bupivacaine Approved, Investigational Phase 4 2180-92-9, 38396-39-3 2474
17
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
18
tannic acid Approved Phase 4 1401-55-4
19
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
20
Sodium oxybate Approved Phase 4 502-85-2 5360545
21
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
22
Promethazine Approved, Investigational Phase 4 60-87-7 4927
23
Suvorexant Approved, Investigational Phase 4 1030377-33-3
24
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
25
Naloxone Approved, Vet_approved Phase 4 465-65-6 5284596
26
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 40400 644073
27
Glutamic acid Approved, Nutraceutical Phase 4 56-86-0 33032
28
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
29 Histamine Antagonists Phase 4
30 Histamine H1 Antagonists Phase 4
31
Histamine Phosphate Phase 4 51-74-1 65513
32 Cyclooxygenase 2 Inhibitors Phase 4
33 Antiemetics Phase 4
34 Cytochrome P-450 Enzyme Inhibitors Phase 4
35 Mitogens Phase 4
36 Trace Elements Phase 4
37 Micronutrients Phase 4
38 Nutrients Phase 4
39 Quetiapine Fumarate Phase 4 111974-72-2
40 Antipsychotic Agents Phase 4
41 Amitriptyline, perphenazine drug combination Phase 4
42 Cyclooxygenase Inhibitors Phase 4
43 Antipyretics Phase 4
44 Hydrocortisone 17-butyrate 21-propionate Phase 4
45 Hydrocortisone hemisuccinate Phase 4
46 Lisdexamfetamine Dimesylate Phase 4
47 Excitatory Amino Acid Antagonists Phase 4
48 Anesthetics, Dissociative Phase 4
49 Immunoglobulins Phase 4
50 Antibodies Phase 4

Interventional clinical trials:

(show top 50) (show all 1016)
# Name Status NCT ID Phase Drugs
1 Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? A Randomized, Double-blinded, Placebo-controlled, Crossover Study. Unknown status NCT02806440 Phase 4 Low dose naltrexone;Placebo
2 Study Proposal - A Randomized Double-blinded Study Comparing Adding Etoricoxib Versus Placebo to Female Patients With Fibromyalgia-analysis of Organic and Psychiatric Measures Unknown status NCT00755521 Phase 4 etoricoxib
3 An Eight Week, Double-Blind Efficacy Study of Cyclobenzaprine ER (Amrix TM) Augmentation to Alleviate Fibromyalgia Fatigue and Muscle Pain Unknown status NCT01041495 Phase 4 cyclobenzaprine ER (AMRIX);placebo
4 Neurologic Signatures of Chronic Pain Disorders Unknown status NCT02747940 Phase 4 flunarizine and/or pregabalin
5 A Double-Blind, Placebo-Controlled, Enriched Enrollment Randomized Withdrawal Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
6 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
7 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
8 The Efficacy of Topical Thiocolchicoside in Cervical Myofascial Pain Syndrome: Triple-Arm, Single-Blind, Randomized, Prospective, Phase IV Clinical Study Completed NCT00272532 Phase 4 Thiocolchicoside
9 Treatment of Myofascial Pain Syndrome With Lidocaine Injection and Physical Therapy, Alone or in Combination: a Single-blind, Randomized, Controlled Clinical Trial. Completed NCT01250184 Phase 4 Lidocaine injection
10 A 15 Week, Randomized, Double Blind, Parallel-group, Placebo-controlled, Flexible-dose, Safety And Efficacy Study Of Pregabalin In Adolescents (12-17 Years Old) With Fibromyalgia Completed NCT01020474 Phase 4 placebo;pregabalin (Lyrica)
11 A 6-month, Open-label, Safety Trial Of Pregabalin In Adolescent Patients With Fibromyalgia Completed NCT01020526 Phase 4 pregabalin
12 Quetiapine (Seroquel XR) for the Treatment of Fibromyalgia: a Clinical and Mechanistic Pilot Study Completed NCT00983320 Phase 4 quetiapine;placebo
13 A Double Blind, Randomized Placebo Controlled Study of the Efficacy, Safety and Tolerability of Quetiapine Fumarate Sustained Release(Seroquel SRTM) in the Treatment of Major Depression With Comorbid Fibromyalgia Syndrome. Completed NCT00675896 Phase 4 Quetiapine Fumarate Sustained Release;Placebo
14 A Randomized, Double-Blind Comparison of Duloxetine 30 mg QD and Placebo in Adult Patients With Fibromyalgia Completed NCT00965081 Phase 4 Duloxetine;Placebo
15 Open Label Trial Concerning the Effectiveness of Trazodone in the Treatment of Fibromyalgia (Phase I) and Its Augmentation With Pregabalin in Trazodone Partial Responders (Phase II) Completed NCT00791739 Phase 4 trazodone, pregabalin
16 A Randomized, Pilot Clinical Trial to Assess the Comparative Efficacy and Tolerability of Quetiapine XR Versus Amitriptyline for the Treatment of Patients With Fibromyalgia Completed NCT00766350 Phase 4 amitriptyline;quetiapine
17 A Multicenter, Randomized, Double-blind, Placebo-Controlled Discontinuation Study of the Durability of Effect of Milnacipran for the Treatment of Fibromyalgia in Patients Receiving Long-term Milnacipran Treatment Completed NCT01014585 Phase 4 Placebo;Milnacipran
18 Flexible Dosed Duloxetine Versus Placebo in the Treatment of Fibromyalgia Completed NCT00673452 Phase 4 duloxetine hydrochloride;placebo
19 A Pilot Study on the Combined Use of Cognitive Behavioral Therapy (CBT) and Milnacipran Completed NCT01038323 Phase 4 Educational with milnacipran
20 A Randomized Controlled Trial Comparing the Efficay and Tolerability of Ai Chi Versus Stretching in Fibromyalgia Management: a Six Months Study Completed NCT00600574 Phase 4
21 Eszopiclone in the Treatment of Insomnia and Associated Symptoms of Fibromyalgia Completed NCT00392041 Phase 4 Eszopiclone;placebo
22 Combining N-of-1 Trials to Assess Fibromyalgia Therapies Completed NCT00000428 Phase 4 Amitriptyline;Amitriptyline plus Fluoxitine
23 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed NCT01234675 Phase 4 Milnacipran;Placebo
24 Pool-based Exercise in Fibromyalgia Management: a Prospective Randomized Comparison Between Stretching and Ai Chi Completed NCT00550641 Phase 4
25 Quetiapine Compared With Placebo in the Management of Fibromyalgia Completed NCT01458964 Phase 4 Quetiapine
26 An Open-Label Pilot Study to Assess Potential Mechanisms for Fibromyalgia in Peripheral Tissue Innervation That Could Predict Therapeutic Responsiveness to Milnacipran Completed NCT01125423 Phase 4 Milnacipran
27 Paroxetine-CR (Paxil-CR) in the Treatment of Patients With Fibromyalgia Syndrome: A Randomized, Double Blind, Parallel Group, Flexible Dose, Placebo Controlled Trial. Completed NCT00610610 Phase 4 Paroxetine CR;Placebo
28 A Multicenter, Randomized, Double-Blind, Placebo-Controlled Switch Study to Evaluate the Safety, Tolerability and Efficacy of Milnacipran in Patients With an Inadequate Response to Duloxetine for the Treatment of Fibromyalgia Completed NCT01077375 Phase 4 Placebo;Milnacipran
29 Fixed Versus Flexible Dosing of Pregabalin in Patients With Fibromyalgia Completed NCT01226667 Phase 4 Pregabalin
30 Effectiveness of Strengthening Exercises Using the Swiss Ball for Patients With Fibromyalgia: a Randomized Controlled Trial Completed NCT02063750 Phase 4
31 Ultracet (Tramadol HCL [37.5 mg]/Acetaminophen [325 mg]) Combination Tablets in the Treatment of the Pain of Fibromyalgia Completed NCT00766675 Phase 4 Tramadol hydrochloride;Acetaminophen
32 Probe Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
33 Effects of a 12 Week Milnacipran 200 mg Treatment on Pain Perception and Pain Processing in Fibromyalgia - An Open Label Study Completed NCT01288807 Phase 4 Milnacipram
34 Perception of Discomfort and Psychosocial Difficulties in People With Diagnosis of Fibromyalgia and Predominant Neck Pain Completed NCT02078791 Phase 4 Botox infiltration
35 A Randomized, Double-blind,Placebo-controlled, Two-way Crossover Study to Evaluate the Effect of Milnacipran on Pain Processing and Functional Magnetic Resonance Imaging Activation Patterns in Patients With Fibromyalgia Completed NCT01173055 Phase 4 milnacipran;Placebo
36 An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue Completed NCT00678691 Phase 4 armodafinil;placebo
37 A Pilot Study on the Use of Nociceptive Flexion Reflex for Fibromyalgia Completed NCT00965601 Phase 4
38 The Study of Heart Rate Variability in Patients With Fibromyalgia - Effects of Strengthening Exercises Completed NCT02004405 Phase 4
39 Randomized, Double-blind, Placebo-controlled Trial to Measure the Efficacy and Safety of Vitamin D3 in Patients With Fibromyalgia. Completed NCT03369379 Phase 4 D3 Vitamin
40 Plasma Rich in Growth Factors Effectiveness for Myofascial Pain Treatment in Masticatory Muscles: a Randomized Controlled Clinical Trial Completed NCT04040309 Phase 4 Lidocaine injection
41 The Serotonin Receptor Type 3 Antagonist Granisetron as a New Treatment Approach for Patients With Chronic Myofascial Pain in the Orofacial Muscles Completed NCT02230371 Phase 4 Granisetron;Control (placebo)
42 MuscleCare™ Pain Relief Therapy vs. Voltaren® in the Relief of Trapezius Trigger Point Musculoskeletal Pain. Completed NCT03939884 Phase 4 MuscleCare Topical Product;Voltaren Topical;Nivea, Topical Cream
43 A Randomized, Single-dose, Parallel-group Study to Evaluate the Pharmacokinetic Profiles of Two Formulation of Pregabalin in Healthy Volunteers Under Fasting Conditions Completed NCT03712475 Phase 4 Pregabalin
44 Patient Self-administration of Cortisol for Cortisol-responding Disorders in Men and Women Over the Age of 17, Demonstration of Double-blind Trial Results Completed NCT03558971 Phase 4 Cortisol
45 Use of Lisdexamfetamine Dimesylate in Treatment of Cognitive Impairment (Chronic Fatigue Syndrome): A Double Blind, Placebo Controlled Study Completed NCT01071044 Phase 4 Lisdexamfetamine Dimesylate;Placebo "30, 50 or 70 mg"
46 Milnacipran in the Treatment of Widespread, Non-Joint Pain in Rheumatoid Arthritis Completed NCT01207453 Phase 4 Milnacipran;Placebo
47 Efficacy of Pregabalin in Patients With Radicular Pain Completed NCT00908375 Phase 4 Pregabalin;Sugar Pill
48 An Open-Label Trial of Duloxetine for the Treatment of Irritable Bowel Syndrome Without Comorbid Major Depressive Disorder Completed NCT00401258 Phase 4 duloxetine
49 An Open Label Trial of Duloxetine in the Treatment of Irritable Bowel Syndrome and Comorbid Generalized Anxiety Disorder Completed NCT00961298 Phase 4 Duloxetine
50 Randomized Double-blind Study Comparing the Efficacy of Duloxetine With Placebo in Patients With Chronic Low Back Pain With a Radicular Component Completed NCT01166048 Phase 4 Duloxetine;Duloxetine

Search NIH Clinical Center for Fibromyalgia

Cochrane evidence based reviews: fibromyalgia

Sources

Genetic Tests for Fibromyalgia

About this section
Sources

Anatomical Context for Fibromyalgia

About this section

MalaCards organs/tissues related to Fibromyalgia:

40
Brain, Testes, Skin, Breast, Heart, Cortex, Spinal Cord
Sources

Publications for Fibromyalgia

About this section

Articles related to Fibromyalgia:

(show top 50) (show all 10217)
# Title Authors PMID Year
1
Impact of herbs and dietary supplements in patients with fibromyalgia: A protocol for a systematic review and meta-analysis of randomized controlled trials. 42 61
32481303 2020
2
Fibromyalgia. 61 42
32120395 2020
3
The Second International Congress on Controversies in Fibromyalgia. 61 42
32116217 2020
4
Pathophysiology of fibromyalgia: a comparison with the tension-type headache, a localized pain syndrome. 61 54
20398011 2010
5
Genetic influences on the dynamics of pain and affect in fibromyalgia. 61 54
20230086 2010
6
Candidate-gene approach in fibromyalgia syndrome: association analysis of the genes encoding substance P receptor, dopamine transporter and alpha1-antitrypsin. 61 54
20074437 2009
7
Autonomic dysfunction and neuropeptide Y in fibromyalgia. 54 61
20074444 2009
8
The relationship between a common catechol-O-methyltransferase (COMT) polymorphism val(158) met and fibromyalgia. 54 61
20074440 2009
9
Polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase genes: a study on fibromyalgia susceptibility. 54 61
18196244 2008
10
Cerebrospinal fluid corticotropin-releasing factor concentration is associated with pain but not fatigue symptoms in patients with fibromyalgia. 54 61
16936702 2006
11
Corticotropin releasing factor in urine--a possible biochemical marker of fibromyalgia. Responses to massage and guided relaxation. 54 61
16716515 2006
12
Increased expression of N-methyl-D-aspartate receptor subunit 2D in the skin of patients with fibromyalgia. 54 61
16583480 2006
13
Alteration of serotonin transporter density and activity in fibromyalgia. 61 54
16790074 2006
14
alpha1-Antitrypsin and fibromyalgia: new data in favour of the inflammatory hypothesis of fibromyalgia. 61 54
15694694 2005
15
Alpha1-antitrypsin replacement therapy controls fibromyalgia symptoms in 2 patients with PI ZZ alpha1-antitrypsin deficiency. 54 61
15468381 2004
16
Increase in peripheral benzodiazepine receptors on monocytes in fibromyalgia. 54 61
15252208 2004
17
Mutational analysis of serotonin receptor genes: HTR3A and HTR3B in fibromyalgia patients. 61 54
15293096 2004
18
Open trial of mirtazapine in patients with fibromyalgia. 54 61
15467973 2004
19
Efficacy and tolerability of intravenous tropisetron in the treatment of fibromyalgia. 61 54
15370724 2004
20
Confirmation of an association between fibromyalgia and serotonin transporter promoter region (5- HTTLPR) polymorphism, and relationship to anxiety-related personality traits. 54 61
11920428 2002
21
Neuroendocrine and immune aspects of fibromyalgia. 61 54
11543693 2001
22
Responses of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis to interleukin-6: a pilot study in fibromyalgia. 61 54
10765933 2000
23
Efficacy and tolerability of tropisetron in primary fibromyalgia--a highly selective and competitive 5-HT3 receptor antagonist. German Fibromyalgia Study Group. 61 54
11028832 2000
24
Possible association of fibromyalgia with a polymorphism in the serotonin transporter gene regulatory region. 61 54
10555044 1999
25
Lower serum activity of prolyl endopeptidase in fibromyalgia is related to severity of depressive symptoms and pressure hyperalgesia. 61 54
9723150 1998
26
Plasma levels on nociceptin in female fibromyalgia syndrome patients. 61 54
10025089 1998
27
Pathogenetic aspects of responsiveness to ondansetron (5-hydroxytryptamine type 3 receptor antagonist) in patients with primary fibromyalgia syndrome--a preliminary study. 61 54
8856622 1996
28
The 5-HT3 blockers in the treatment of the primary fibromyalgia syndrome: a 10-day open study with Tropisetron at a low dose. 61 54
9088121 1996
29
Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. 54 61
7980669 1994
30
The therapeutic efficacy of Qigong exercise on the main symptoms of fibromyalgia: A pilot randomized clinical trial. 61
32455108 2020
31
Mitochondria and immunity in chronic fatigue syndrome. 61
32470498 2020
32
Characterization of β-cyclodextrin/myrtenol complex and its protective effect against nociceptive behavior and cognitive impairment in a chronic musculoskeletal pain model. 61
32536383 2020
33
Extended overview of the longitudinal pain-depression association: A comparison of six cohorts treated for specific chronic pain conditions. 61
32560947 2020
34
Default mode network changes in fibromyalgia patients are largely dependent on current clinical pain. 61
32344063 2020
35
Magnetic resonance imaging of neuroinflammation in chronic pain: a role for astrogliosis? 61
31990749 2020
36
Comorbid fibromyalgia impairs the effectiveness of biologic drugs in patients with psoriatic arthritis. 61
31652315 2020
37
Peripheral immune aberrations in fibromyalgia: A systematic review, meta-analysis and meta-regression. 61
31887417 2020
38
Ultrasound Assessment of Disease Activity Prevents Disease-Modifying Antirheumatic Drug (DMARD) Escalation and May Reduce DMARD-Related Direct Costs in Rheumatoid Arthritis With Fibromyalgia: An Exploratory Study. 61
31958164 2020
39
Pain catastrophizing mediates the negative influence of pain and trait-anxiety on health-related quality of life in fibromyalgia. 61
32112278 2020
40
Increased Anandamide and Decreased Pain and Depression after Exercise in Fibromyalgia. 61
32168104 2020
41
Association of catechol-O-methyltranferase 472G>A (Val158Met) polymorphism with susceptibility to fibromyalgia syndrome. 61
32127730 2020
42
Pressure Pain Tolerance Predicts the Success of Emotional Awareness and Expression Therapy in Patients With Fibromyalgia. 61
32271184 2020
43
Hippocampal oscillatory dynamics and sleep atonia are altered in an animal model of fibromyalgia: Implications in the search for biomarkers. 61
31785155 2020
44
Fibromyalgia. Old opinions versus new knowledge. 61
32499131 2020
45
Chronic Pain and Sleep Disturbances: A Pragmatic Review of Their Relationships, Comorbidities, and Treatments. 61
31909797 2020
46
Social defeat stress-induced hyperalgesia is mediated by nav 1.8+ nociceptive fibers. 61
32387758 2020
47
Rheumatic Care in Under-Resourced Areas Using the Extension for Community Healthcare Outcomes Model. 61
30927517 2020
48
Opioid crisis in primary care? An audit of high-dose opioid prescribing at Bangholm GP Practice. 61
32554680 2020
49
Down-regulation of Spinal 5-HT2A and 5-HT2C Receptors Contributes to Somatic Hyperalgesia induced by Orofacial Inflammation Combined with Stress. 61
32497757 2020
50
Physical activity measures in patients with myalgic encephalomyelitis/chronic fatigue syndrome: correlations between peak oxygen consumption, the physical functioning scale of the SF-36 questionnaire, and the number of steps from an activity meter. 61
32513266 2020
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Variations for Fibromyalgia

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Expression for Fibromyalgia

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Search GEO for disease gene expression data for Fibromyalgia.
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Pathways for Fibromyalgia

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Pathways related to Fibromyalgia according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Peptide ligand-binding receptors 65
Show member pathways
 13.35 TSPO TACR1 POMC PNOC OPRM1 NPY
2
cAMP signaling pathway 36
12.18 POMC NPY GRIN2D BDNF
3
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.04 TNF IL6 IGF1 CXCL8 BDNF
4
Spinal Cord Injury 1
11.8 TNF TACR1 IL6 CXCL8 BDNF
5
Interleukin-4 and 13 signaling 65
11.71 TNF POMC OPRM1 IL6 CXCL8
6
Glucocorticoid receptor regulatory network 1
11.67 POMC IL6 CXCL8
7
Pertussis 36
11.62 TNF IL6 CXCL8
8
Adipocytokine signaling pathway 36
11.57 TNF POMC NPY
9
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.51 TNF IL6 CXCL8
10
Legionellosis 36
11.44 TNF IL6 CXCL8
11
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.43 TNF TACR1 SLC6A4 IL6 HTR3A HTR2A
12
Malaria 36
11.37 TNF IL6 CXCL8
13
Interleukin-10 signaling 65
11.34 TNF IL6 CXCL8
14
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
11.29 TNF IL6 IGF1
15
Lung fibrosis 1
11.15 TNF SERPINA1 IL6 IGF1 CXCL8
16
Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics 60
11.03 SLC6A4 HTR3A HTR2A
17
Overview of nanoparticle effects 1
10.74 TNF IL6 CXCL8 CRP
18
Glucocorticoid Pathway (HPA Axis), Pharmacodynamics 60
10.37 POMC CRH
Sources

GO Terms for Fibromyalgia

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Cellular components related to Fibromyalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10 TNF SERPINA1 POMC PNOC NPY IL6
2 synapse GO:0045202 9.87 SLC6A4 PNOC NPY HTR3A HTR2A GRIN2D
3 extracellular space GO:0005615 9.85 TNF SERPINA1 POMC NPY IL6 IGF1
4 dendrite GO:0030425 9.8 PNOC OPRM1 HTR2A COMT BDNF
5 axon GO:0030424 9.77 OPRM1 HTR3A HTR2A COMT BDNF
6 integral component of presynaptic membrane GO:0099056 9.26 SLC6A4 OPRM1 HTR3A HTR2A
7 integral component of postsynaptic membrane GO:0099055 8.92 SLC6A4 OPRM1 HTR3A HTR2A

Biological processes related to Fibromyalgia according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 10.03 TACR1 POMC PNOC OPRM1 NPY HTR2A
2 positive regulation of gene expression GO:0010628 9.95 TNF SLC6A4 IL6 IGF1 CRP CRH
3 cytokine-mediated signaling pathway GO:0019221 9.91 TNF POMC OPRM1 IL6 CXCL8
4 signal transduction GO:0007165 9.9 TACR1 POMC PNOC OPRM1 IL6 IGF1
5 cellular response to lipopolysaccharide GO:0071222 9.86 TSPO TNF IL6 CXCL8
6 chemical synaptic transmission GO:0007268 9.85 PNOC NPY HTR3A HTR2A CRH
7 inflammatory response GO:0006954 9.8 TNF TACR1 IL6 CXCL8 CRP CRH
8 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.79 TNF IL6 IGF1
9 excitatory postsynaptic potential GO:0060079 9.77 OPRM1 HTR3A GRIN2D
10 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.77 OPRM1 NPY HTR2A
11 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.76 TACR1 OPRM1 HTR2A
12 positive regulation of smooth muscle cell proliferation GO:0048661 9.75 TNF IL6 IGF1
13 negative regulation of tumor necrosis factor production GO:0032720 9.74 TSPO POMC IGF1
14 response to drug GO:0042493 9.73 TSPO SLC6A4 HTR2A CRH COMT BDNF
15 response to cocaine GO:0042220 9.72 OPRM1 HTR3A CRH
16 neuropeptide signaling pathway GO:0007218 9.71 POMC PNOC OPRM1 NPY
17 acute-phase response GO:0006953 9.7 SERPINA1 IL6 CRP
18 regulation of sensory perception of pain GO:0051930 9.67 OPRM1 GRIN2D COMT
19 serotonin receptor signaling pathway GO:0007210 9.61 HTR3A HTR2A
20 positive regulation of appetite GO:0032100 9.54 OPRM1 NPY
21 positive regulation of glial cell proliferation GO:0060252 9.54 TSPO TNF IL6
22 negative regulation of lipid storage GO:0010888 9.13 TNF IL6 CRP
23 response to pain GO:0048265 8.92 TSPO TACR1 CRH COMT

Molecular functions related to Fibromyalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.46 POMC NPY IGF1 CRH
2 neuropeptide hormone activity GO:0005184 9.13 PNOC NPY CRH
3 serotonin binding GO:0051378 8.8 SLC6A4 HTR3A HTR2A
Sources

Sources for Fibromyalgia

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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