MCID: FBR047
MIFTS: 66

Fibromyalgia

Categories: Muscle diseases, Skin diseases

Aliases & Classifications for Fibromyalgia

MalaCards integrated aliases for Fibromyalgia:

Name: Fibromyalgia 12 77 26 38 56 44 3 45 15 64 17 74
Fibromyalgia-Fibromyositis Syndrome 26
Diffuse Myofascial Pain Syndrome 26
Myofascial Pain Syndromes 74
Myofascial Pain Syndrome 26
Fibromyalgia Syndrome 26
Fibromyositis 26
Fibrositis 26
Fms 26

Classifications:



External Ids:

Disease Ontology 12 DOID:631
KEGG 38 H01636
MeSH 45 D005356
ICD10 34 M79.1 M79.7

Summaries for Fibromyalgia

PubMed Health : 64 About fibromyalgia: Fibromyalgia (also known as fibromyalgia syndrome or FMS) is a chronic condition that causes pain in various parts of the body. The pain may be felt in the skin, muscles and joints. Other typical symptoms include sleep problems, exhaustion and trouble concentrating.Although fibromyalgia has been recognized as an illness for 30 years now, people who have it are still sometimes made to feel like it’s all in their head. Part of the reason for this is that not many people are aware of fibromyalgia, and healthy people find it hard to understand. This often makes it even harder to live with the condition.Sometimes people who have fibromyalgia are told that the pain can’t be treated. But research has shown that there are indeed treatments that can relieve the typical symptoms. And many people learn to cope better with the pain over time. They find out what activities they can handle – and when to take things easier.It’s good to know that fibromyalgia isn’t a dangerous condition. It doesn’t affect people’s organs or life expectancy.

MalaCards based summary : Fibromyalgia, also known as fibromyalgia-fibromyositis syndrome, is related to interstitial cystitis and infective endocarditis, and has symptoms including muscle weakness, fatigue and myoclonus. An important gene associated with Fibromyalgia is COMT (Catechol-O-Methyltransferase), and among its related pathways/superpathways are Peptide ligand-binding receptors and Cytokine Signaling in Immune system. The drugs Etoricoxib and Naltrexone have been mentioned in the context of this disorder. Affiliated tissues include brain, skin and testes, and related phenotypes are behavior/neurological and endocrine/exocrine gland

Genetics Home Reference : 26 Fibromyalgia is a common condition characterized by long-lasting (chronic) pain affecting many areas of the body. The pain is associated with tenderness that occurs with touch or pressure on the muscles, joints, or skin. Some affected individuals also report numbness, tingling, or a burning sensation (paresthesia) in the arms and legs.

MedlinePlus : 44 Fibromyalgia is a disorder that causes muscle pain and fatigue. People with fibromyalgia have "tender points" on the body. Tender points are specific places on the neck, shoulders, back, hips, arms, and legs. These points hurt when pressure is put on them. People with fibromyalgia may also have other symptoms, such as Trouble sleeping Morning stiffness Headaches Painful menstrual periods Tingling or numbness in hands and feet Problems with thinking and memory (sometimes called "fibro fog") No one knows what causes fibromyalgia. Anyone can get it, but it is most common in middle-aged women. People with rheumatoid arthritis and other autoimmune diseases are particularly likely to develop fibromyalgia. There is no cure for fibromyalgia, but medicine can help you manage your symptoms. Getting enough sleep, exercising, and eating well may also help. NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases

CDC : 3 Fibromyalgia (fi·bro·my·al·gi·a) is a condition that causes pain all over the body (also referred to as widespread pain), sleep problems, fatigue, and often emotional and mental distress. People with fibromyalgia may be more sensitive to pain than people without fibromyalgia. This is called abnormal pain perception processing. Fibromyalgia affects about 4 million US adults, about 2% of the adult population. The cause of fibromyalgia is not known, but it can be effectively treated and managed.

Wikipedia : 77 Fibromyalgia (FM) is a medical condition characterised by chronic widespread pain and a heightened pain... more...

Related Diseases for Fibromyalgia

Diseases related to Fibromyalgia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 709)
# Related Disease Score Top Affiliating Genes
1 interstitial cystitis 32.7 BDNF CXCL8 IL6
2 infective endocarditis 31.7 CRP IL6 TNF
3 endocarditis 31.5 CRP CXCL8 IL6 TNF
4 depression 31.2 BDNF CRH HTR2A SLC6A4
5 alexithymia 30.8 COMT CRP SLC6A4
6 interstitial lung disease 30.7 CXCL8 IL6 TNF
7 lung disease 30.5 CXCL8 IL6 SERPINA1 TNF
8 irritable bowel syndrome 30.5 CRH HTR3A SLC6A4 TNF
9 pneumonia 30.4 CRP CXCL8 IL6 TNF
10 chronic fatigue syndrome 30.3 COMT CRH HTR2A IGF1 IL6 POMC
11 bipolar disorder 30.3 BDNF COMT HTR2A SLC6A4
12 personality disorder 30.2 BDNF COMT HTR2A SLC6A4
13 migraine with or without aura 1 30.2 COMT HTR2A HTR3A SLC6A4 TNF
14 allergic encephalomyelitis 30.2 CRH POMC
15 vasculitis 30.2 CRP SERPINA1 TNF
16 complex regional pain syndrome 30.1 IL6 NPY TNF
17 dyspepsia 30.1 CXCL8 HTR3A SLC6A4
18 serotonin syndrome 30.1 HTR2A HTR3A SLC6A4
19 cholangitis 30.1 CRP IL6 TNF
20 monocytic leukemia 30.1 CXCL8 IL6 TNF
21 lyme disease 30.0 CRP IL6 TNF
22 obstructive jaundice 30.0 CRP CXCL8 IL6 TNF
23 arteries, anomalies of 29.9 CRP IL6 TNF
24 brain injury 29.9 BDNF COMT IGF1 IL6
25 fasciitis 29.9 CXCL8 IL6 TNF
26 post-traumatic stress disorder 29.9 BDNF COMT CRH CRP HTR2A SLC6A4
27 pericarditis 29.9 CRP IL6 TNF
28 atypical depressive disorder 29.9 CRH HTR2A SLC6A4
29 juvenile rheumatoid arthritis 29.9 CRP IL6 TNF
30 acute pancreatitis 29.9 CRP CXCL8 IL6
31 bronchiolitis obliterans 29.9 CXCL8 IL6 TNF
32 acute cystitis 29.8 CRP CXCL8 IL6
33 otitis media 29.8 CXCL8 IL6 TNF
34 borderline personality disorder 29.8 BDNF COMT HTR2A SLC6A4
35 bronchiolitis 29.7 CRP CXCL8 IL6 TNF
36 temporal arteritis 29.7 CRP IL6 TNF
37 apnea, obstructive sleep 29.7 CRP HTR2A IL6 TNF
38 acute respiratory distress syndrome 29.7 CXCL8 IL6 TNF
39 cystitis 29.7 CRP CXCL8 IL6 TNF
40 kawasaki disease 29.7 CRP IL6 TNF
41 transverse myelitis 29.7 CXCL8 IL6 TNF
42 opioid addiction 29.7 COMT GRIN2D OPRM1
43 pulmonary edema 29.7 CRP CXCL8 TNF
44 tonsillitis 29.6 CXCL8 IL6 TNF
45 adult respiratory distress syndrome 29.6 CXCL8 IL6 TNF
46 hypopituitarism 29.6 CRH IGF1 POMC
47 synovitis 29.6 CRP CXCL8 IL6 TNF
48 spondylitis 29.6 CRP IL6 TNF
49 ulcerative colitis 29.6 CRP CXCL8 IL6 TNF
50 anxiety 29.5 BDNF COMT CRH HTR2A HTR3A NPY

Graphical network of the top 20 diseases related to Fibromyalgia:



Diseases related to Fibromyalgia

Symptoms & Phenotypes for Fibromyalgia

UMLS symptoms related to Fibromyalgia:


muscle weakness, fatigue, myoclonus, back pain, myalgia, pain, torticollis, chronic pain, sciatica, muscle cramp, muscle rigidity, muscle spasticity, myofascial trigger point pain

MGI Mouse Phenotypes related to Fibromyalgia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.3 BDNF COMT CRH GRIN2D HTR2A HTR3A
2 endocrine/exocrine gland MP:0005379 10.18 BDNF COMT CRH HTR2A HTR3A IGF1
3 homeostasis/metabolism MP:0005376 10.17 BDNF COMT CRH CRP GRIN2D HTR3A
4 growth/size/body region MP:0005378 10.15 BDNF CRH GRIN2D HTR3A IGF1 IL6
5 cardiovascular system MP:0005385 10.09 COMT CRP GRIN2D IGF1 IL6 POMC
6 adipose tissue MP:0005375 10.08 CRH GRIN2D IGF1 IL6 NPY OPRM1
7 immune system MP:0005387 9.96 COMT CRH CRP HTR3A IGF1 IL6
8 integument MP:0010771 9.85 BDNF CRH GRIN2D HTR3A IGF1 IL6
9 nervous system MP:0003631 9.77 BDNF COMT CRH GRIN2D HTR3A IGF1
10 renal/urinary system MP:0005367 9.17 COMT CRH HTR3A IGF1 IL6 NPY

Drugs & Therapeutics for Fibromyalgia

PubMedHealth treatment related to Fibromyalgia: 64

Many people who have fibromyalgia avoid physical activity for fear of making the pain worse or overdoing it. But research has shown that exercise and gentle sports (e.g. cycling or Nordic walking) can improve their wellbeing, strengthen their body and relieve the pain somewhat. So they are an important part of the treatment.Certain medications have been proven to greatly reduce fibromyalgia pain in some people. These include amitriptyline, duloxetine, milnacipran and pregabalin. They all influence certain chemical messengers that also affect how we feel pain. These drugs were originally developed for the treatment of depression or epilepsy. When used in the treatment of fibromyalgia, though, they aren’t used for their antidepressant or anti-epileptic effects. Conventional painkillers such as diclofenac, ibuprofen or acetaminophen (paracetamol) generally aren’t recommended for the treatment of fibromyalgia.Many people with fibromyalgia find certain types of physical therapy to be pleasant, especially resting and/or moving in warm water. Some also say that going to the sauna or having gentle massages help.Multimodal pain management can be a good idea, particularly if the fibromyalgia pain is strong. This approach combines movement, relaxation and pain management techniques used in cognitive behavioral therapy (CBT). CBT and other psychological treatments can help people to cope better with pain and other symptoms in everyday life. Medication can be used as well.If someone also has other illnesses such as arthritis or psychological problems such as depression, it’s important to treat those conditions too.

Drugs for Fibromyalgia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 358)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoricoxib Approved, Investigational Phase 4 202409-33-4 123619
2
Naltrexone Approved, Investigational, Vet_approved Phase 4,Phase 2,Not Applicable 16590-41-3 5360515
3
Ethanol Approved Phase 4,Phase 3,Phase 2,Not Applicable 64-17-5 702
4
Benzocaine Approved, Investigational Phase 4,Phase 1,Phase 2,Not Applicable 1994-09-7, 94-09-7 2337
5
Norepinephrine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-41-2 439260
6
Levomilnacipran Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 96847-54-0
7
tannic acid Approved Phase 4,Phase 1,Phase 2,Not Applicable 1401-55-4
8
Milnacipran Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 92623-85-3 65833
9
Cyclobenzaprine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 303-53-7 2895
10
Amitriptyline Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 50-48-6 2160
11
Dinoprostone Approved Phase 4 363-24-6 5280360
12
Gabapentin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 60142-96-3 3446
13
Perphenazine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 58-39-9 4748
14
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 148553-50-8 5486971
15
Acetylcholine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 51-84-3 187
16
Dopamine Approved Phase 4,Phase 3,Phase 2,Not Applicable 62-31-7, 51-61-6 681
17
Tramadol Approved, Investigational Phase 4,Phase 3,Phase 2 27203-92-5 33741
18
Acetaminophen Approved Phase 4,Phase 3,Phase 2,Not Applicable 103-90-2 1983
19
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 137-58-6 3676
20
Naloxone Approved, Vet_approved Phase 4,Phase 2,Phase 1,Not Applicable 465-65-6 5284596
21
Paroxetine Approved, Investigational Phase 4,Phase 1,Phase 2 61869-08-7 43815
22
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
23
Fluoxetine Approved, Vet_approved Phase 4,Phase 3,Phase 2 54910-89-3 3386
24
Eszopiclone Approved, Investigational Phase 4 138729-47-2 969472
25
Modafinil Approved, Investigational Phase 4,Phase 3 68693-11-8 4236
26
Colchicine Approved Phase 4 64-86-8 2833 6167
27
Hydrocortisone Approved, Vet_approved Phase 4,Early Phase 1,Not Applicable 50-23-7 5754
28
Hydrocortisone acetate Approved, Vet_approved Phase 4,Early Phase 1,Not Applicable 50-03-3
29
Granisetron Approved, Investigational Phase 4 109889-09-0 3510
30
Iron Approved, Experimental Phase 4,Phase 3,Phase 2 7439-89-6, 15438-31-0 27284 23925
31
Deferasirox Approved, Investigational Phase 4 201530-41-8 5493381
32
Hyaluronic acid Approved, Vet_approved Phase 4,Phase 1 9004-61-9 53477741
33
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
34
Histamine Approved, Investigational Phase 4,Phase 3,Phase 2 51-45-6 774
35
Sodium oxybate Approved Phase 4,Phase 3,Phase 2 502-85-2 5360545
36
Flunarizine Approved Phase 4 52468-60-7 941361
37
Suvorexant Approved, Investigational Phase 4 1030377-33-3
38
Promethazine Approved, Investigational Phase 4 60-87-7 4927
39
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
40
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
41
Buprenorphine Approved, Illicit, Investigational, Vet_approved Phase 4 52485-79-7 644073 40400
42
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
43
Calcium Approved, Nutraceutical Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 7440-70-2 271
44
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4 1406-16-2
45
Glutamic Acid Approved, Nutraceutical Phase 4,Not Applicable 56-86-0 33032
46
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
47
Vitamin A Approved, Nutraceutical, Vet_approved Phase 4,Not Applicable 68-26-8, 22737-96-8, 11103-57-4 9904001 445354
48 Anti-Inflammatory Agents, Non-Steroidal Phase 4,Phase 2,Phase 1,Not Applicable
49 Cyclooxygenase Inhibitors Phase 4,Phase 2,Phase 1,Not Applicable
50 Analgesics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 936)
# Name Status NCT ID Phase Drugs
1 Study Assessing the Efficacy of Etoricoxib in Female Patients With Fibromyalgia Unknown status NCT00755521 Phase 4 etoricoxib
2 Low Dose Naltrexone for Treatment of Pain in Patients With Fibromyalgia - Effect Via a Central Mechanism? Unknown status NCT02806440 Phase 4 Low dose naltrexone;Placebo
3 Study of Fibromyalgia Treated With Milnacipran Unknown status NCT01125423 Phase 4 Milnacipran
4 Cyclobenzaprine Extended Release (ER) for Fibromyalgia Unknown status NCT01041495 Phase 4 cyclobenzaprine ER (AMRIX);placebo
5 The Immune and Clinical Impacts of Vitamin D in Patients With Chronic Musculo-skeletal Pain Unknown status NCT01417923 Phase 4 vitamin D
6 Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis Unknown status NCT01329406 Phase 4 Milnacipran;Placebo
7 The Impact of Perioperative Gabapentin on Chronic Groin Pain After Inguinal Hernia Repair Unknown status NCT02419443 Phase 4 Gabapentin;Placebo
8 Quetiapine Compared With Placebo in the Management of Fibromyalgia Completed NCT01458964 Phase 4 Quetiapine
9 Effect of Milnacipran on Pain in Fibromyalgia Completed NCT01288807 Phase 4 Milnacipram
10 Valuation of Efficacy and Safety of Vitamin D3 Use in 80 Women Diagnosed With Fibromyalgia. Using FIQ Score and VAS. Completed NCT03369379 Phase 4 D3 Vitamin
11 Pool-based Exercise in Fibromyalgia Management Completed NCT00550641 Phase 4
12 Comparative Efficacy and Tolerability of Quetiapine XR and Amitriptyline in the Treatment of Fibromyalgia Completed NCT00766350 Phase 4 amitriptyline;quetiapine
13 Quetiapine (Seroquel XR) for the Treatment of Fibromyalgia: a Clinical and Mechanistic Pilot Study Completed NCT00983320 Phase 4 quetiapine;placebo
14 Paroxetine-CR (Paxil-CR) in the Treatment of Patients With Fibromyalgia Syndrome Completed NCT00610610 Phase 4 Paroxetine CR;Placebo
15 Strengthening Exercises for Fibromyalgia Completed NCT02063750 Phase 4
16 A Pilot Study on the Use of Nociceptive Flexion Reflex for Fibromyalgia Completed NCT00965601 Phase 4
17 Trazodone and Its Augmentation With Pregabalin in the Treatment of Fibromyalgia Completed NCT00791739 Phase 4 trazodone, pregabalin
18 Discomfort and Psychosocial Difficulties in Fibromyalgia Completed NCT02078791 Phase 4 Botox infiltration
19 Discontinuation Study of the Durability of Effect of Milnacipran for the Treatment of Fibromyalgia Completed NCT01014585 Phase 4 Placebo;Milnacipran
20 Combining N-of-1 Trials to Assess Fibromyalgia Treatments Completed NCT00000428 Phase 4 Amitriptyline;Amitriptyline plus Fluoxitine
21 Drug and Talk Therapy for Fibromyalgia Completed NCT01038323 Phase 4 Educational with milnacipran
22 Adolescent Fibromyalgia Study Completed NCT01020474 Phase 4 placebo;pregabalin (Lyrica)
23 Heart Rate Variability in Fibromyalgia - Effects of Strengthening Exercises Completed NCT02004405 Phase 4
24 Fixed Versus Flexible Dosing of Pregabalin in Patients With Fibromyalgia Completed NCT01226667 Phase 4 Pregabalin
25 Ai Chi Versus Stretching in Fibromyalgia Management Completed NCT00600574 Phase 4
26 A Study for Adult Patients With Fibromyalgia Completed NCT00965081 Phase 4 Duloxetine;Placebo
27 The Effects of Milnacipran on Sleep Disturbance in Fibromyalgia Completed NCT01234675 Phase 4 Milnacipran;Milnacipran
28 A Study to Evaluate the Effects of Milnacipran on Pain Processing and Functional MRI in Patients With Fibromyalgia Completed NCT01173055 Phase 4 milnacipran;Placebo
29 Eszopiclone in the Treatment of Insomnia and Fibromyalgia Completed NCT00392041 Phase 4 Eszopiclone;placebo
30 Pregabalin In Adolescent Patients With Fibromyalgia Completed NCT01020526 Phase 4 pregabalin
31 An Efficacy Study of Combination of Tramadol and Acetaminophen Tablets in the Treatment of Participants With Fibromyalgia Pain Completed NCT00766675 Phase 4 Tramadol hydrochloride;Acetaminophen
32 Study of Milnacipran in Patients With Inadequate Response to Duloxetine for the Treatment of Fibromyalgia Completed NCT01077375 Phase 4 Placebo;Milnacipran
33 A Study Comparing Duloxetine and Placebo in the Treatment of Fibromyalgia Completed NCT00673452 Phase 4 duloxetine hydrochloride;placebo
34 An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue Completed NCT00678691 Phase 4 armodafinil;placebo
35 A Study of Quetiapine Fumarate Sustained Release in Major Depression With Comorbid Fibromyalgia Syndrome Completed NCT00675896 Phase 4 Quetiapine Fumarate Sustained Release;Placebo
36 Treatment of Myofascial Pain Syndrome With Lidocaine Injection and Physical Therapy. Completed NCT01250184 Phase 4 Lidocaine injection
37 EMINEM: Efficacy of Muscoril In NEck Myofascial Syndromes Completed NCT00272532 Phase 4 Thiocolchicoside
38 Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome Completed NCT00241215 Phase 4 Botulinum toxin serotype A
39 Pharmacokinetics of Two Formulation of Pregabalin Completed NCT03712475 Phase 4 Pregabalin
40 Patient Self-administration of Cortisol for Cortisol-responding Disorders in Men and Women Over the Age of 17 Completed NCT03558971 Phase 4 Cortisol
41 Milnacipran for Chronic Pain in Knee Osteoarthritis Completed NCT01510457 Phase 4 Milnacipran;Placebo
42 Comparison of the Efficacy of Duloxetine With Placebo in Patients With Chronic Low Back Pain With a Radicular Component Completed NCT01166048 Phase 4 Duloxetine;Duloxetine
43 Efficacy and Safety of Lisdexamfetamine Dimesylate in Adults With Chronic Fatigue Syndrome Completed NCT01071044 Phase 4 Lisdexamfetamine Dimesylate;Placebo "30, 50 or 70 mg"
44 Study on the Effect of Granisetron on Myofascial Pain in the Orofacial Muscles Completed NCT02230371 Phase 4 Granisetron;Control (placebo)
45 Magnetic Resonance Imaging (MRI) Assessments of the Heart and Liver Iron Load in Patients With Transfusion Induced Iron Overload Completed NCT00673608 Phase 4 deferasirox
46 A Double Blind Study Comparing Hyaluronic Acid, Corticosteroid and Placebo During Arthrocentesis for Temporomandibular Joint (TMJ) Dysfunction Completed NCT01524913 Phase 4 Hyaluronic acid;Corticosteroid;Lactated Ringers
47 Neurologic Signatures of Chronic Pain Disorders Recruiting NCT02747940 Phase 4 flunarizine and/or pregabalin
48 Effect of Duloxetine on Opioid Use After Total Knee Arthroplasty Enrolling by invitation NCT03271151 Phase 4 Cymbalta
49 Influence of Transcranial Direct Current Stimulation of the Primary Motor Cortex on Pain Sensation in Patients Suffering From Fibromyalgia Syndrome Terminated NCT01261650 Phase 4
50 Suvorexant in Insomnia Co-morbid With Fibromyalgia Terminated NCT02684136 Phase 4 suvorexant;placebo

Search NIH Clinical Center for Fibromyalgia

Cochrane evidence based reviews: fibromyalgia

Genetic Tests for Fibromyalgia

Anatomical Context for Fibromyalgia

MalaCards organs/tissues related to Fibromyalgia:

42
Brain, Skin, Testes, Heart, Breast, Bone, Cortex

Publications for Fibromyalgia

Articles related to Fibromyalgia:

(show top 50) (show all 3453)
# Title Authors Year
1
Modulation of autonomic function by physical exercise in patients with fibromyalgia syndrome: A systematic review. ( 30900831 )
2019
2
Fibromyalgia: An Urgent Need for Harmonized, Global, and Patient-Centric Regulatory Guidance for Developing Medications for the Treatment of Pain and Associated Symptoms. ( 30958886 )
2019
3
Importance of feelings of injustice in fibromyalgia, large internet survey on experiences of 4516 french patients. ( 31067504 )
2019
4
Fibromyalgia diagnostic model derived from combination of American College of Rheumatology 1990 and 2011 criteria. ( 31091511 )
2019
5
Performance of the American College of Rheumatology 2016 criteria for fibromyalgia in a referral care setting. ( 31101966 )
2019
6
Sophrology versus resistance training for treatment of women with fibromyalgia: A randomized controlled trial. ( 31103124 )
2019
7
Prevalence of fibromyalgia in physicians in training: a cross-sectional study. ( 30284078 )
2019
8
Therapeutic validity of exercise interventions in the management of fibromyalgia. ( 30293405 )
2019
9
Patients' perspective of the effectiveness and acceptability of pharmacological and non-pharmacological treatments of fibromyalgia. ( 30315738 )
2019
10
Is Aerobic Exercise Training Beneficial for Adults With Fibromyalgia?: A Cochrane Review Summary with Commentary. ( 30422826 )
2019
11
Olfactory and cognitive functioning in patients with fibromyalgia. ( 30453770 )
2019
12
Effect of adding medical cannabis to analgesic treatment in patients with low back pain related to fibromyalgia: an observational cross-over single centre study. ( 30418116 )
2019
13
Melatonin Improves Mood Status and Quality of Life and Decreases Cortisol Levels in Fibromyalgia. ( 30415563 )
2019
14
Evaluation of the performance of extreme patient-reported outcomes as surrogate markers for fibromyalgia in axial spondyloarthritis. ( 30413924 )
2019
15
Hyperbaric oxygen and aerobic exercise in the long-term treatment of fibromyalgia: A narrative review. ( 30399600 )
2019
16
A longitudinal analysis of pain experience and recall in fibromyalgia. ( 30398031 )
2019
17
Erratum: Postural counseling represents a novel option in pain management of fibromyalgia patients [Erratum]. ( 30881104 )
2019
18
Coexistence of Alterations of Gastrointestinal Function and Mechanical Allodynia in the Reserpine-Induced Animal Model of Fibromyalgia. ( 30874990 )
2019
19
Fibromyalgia and myofascial pain syndrome: Two sides of the same coin? A scoping review to determine the lexicon of the current diagnostic criteria. ( 30350334 )
2019
20
Healthcare Provider Advice to Engage in Walking Regimens and Adherence in Women With Fibromyalgia. ( 30601798 )
2019
21
Association between initial opioid use and response to a brief interdisciplinary treatment program in fibromyalgia. ( 30608417 )
2019
22
Long-term outcomes of adolescents with juvenile-onset fibromyalgia into adulthood and impact of depressive symptoms on functioning over time. ( 30335681 )
2019
23
Operant Learning Versus Energy Conservation Activity Pacing Treatments in a Sample of Patients With Fibromyalgia Syndrome: A Pilot Randomized Controlled Trial. ( 30326271 )
2019
24
Evaluation of carotid-femoral pulse wave velocity, aortic stiffness index, and aortic distensibility in patients with fibromyalgia. ( 30635854 )
2019
25
Internet-delivered exposure therapy was cost-effective for increasing treatment response in fibromyalgia. ( 30641562 )
2019
26
Utility of the PROMIS Pediatric Pain Interference Scale in Juvenile Fibromyalgia. ( 30649388 )
2019
27
A systematic review and meta-analysis of the prevalence of small fiber pathology in fibromyalgia: Implications for a new paradigm in fibromyalgia etiopathogenesis. ( 30314675 )
2019
28
Brain responses to other people's pain in fibromyalgia: a magnetoencephalography (MEG) study. ( 30652680 )
2019
29
Sedentary time, physical activity, and sleep quality in fibromyalgia: The al-Ándalus project. ( 30306645 )
2019
30
Are Patients With Fibromyalgia in a Prothrombotic State? ( 30654628 )
2019
31
Does the cognitive index of the symptom severity scale evaluate cognition? Data from subjective and objective cognitive measures in fibromyalgia. ( 30299249 )
2019
32
Fibromyalgia: A misconnection in a multiconnected world? ( 30663833 )
2019
33
Nothing and Everything: Fibromyalgia as a Diagnosis of Exclusion and Inclusion. ( 30296924 )
2019
34
The effect of cognitive behavioral therapy on the circulating proinflammatory cytokines of fibromyalgia patients: A pilot controlled clinical trial. ( 30669022 )
2019
35
Allostatic Overload in Patients with Fibromyalgia: Preliminary Findings. ( 30677771 )
2019
36
Correction to: The role of HHV-6 and HHV-7 infections in the development of fibromyalgia. ( 30680615 )
2019
37
Surgical and Medical Costs for Fibromyalgia Patients Undergoing Total Knee Arthroplasty. ( 31087319 )
2019
38
Influence of depressive feelings in the brain processing of women with fibromyalgia: An EEG study. ( 31083224 )
2019
39
Can aberrant spinal nociception be a marker of chronicity of pain in fibromyalgia syndrome? ( 31080004 )
2019
40
Ameliorative effect of imperatorin in chemically induced fibromyalgia: Role of NMDA/ NFkB mediated downstream signaling. ( 31075267 )
2019
41
Blame it on the weather? The association between pain in fibromyalgia, relative humidity, temperature and barometric pressure. ( 31075151 )
2019
42
Fibromyalgia Increases the Risk of Surgical Complications Following Total Knee Arthroplasty: A Nationwide Database Study. ( 31072747 )
2019
43
Patient-proxy agreement on health-related quality of life in juvenile fibromyalgia syndrome. ( 31072338 )
2019
44
Utilization of Overnight Pulse Oximetry in Fibromyalgia Patients. ( 31069165 )
2019
45
Myalgia with Elevated Inflammatory Markers in an Obese Young Female: Fibromyalgia or Polymyalgia Rheumatica? ( 31064976 )
2019
46
Is insulin resistance the cause of fibromyalgia? A preliminary report. ( 31059525 )
2019
47
Impact of Fibromyalgia on Alpha-2 EEG Power Spectrum in the Resting Condition: A Descriptive Correlational Study. ( 31058192 )
2019
48
Brain Electrical Activity Associated With Visual Attention and Reactive Motor Inhibition in Patients With Fibromyalgia. ( 31048636 )
2019
49
Is fibromyalgia a cause of arthroscopic subacromial decompression failure? ( 31040062 )
2019
50
Impact of adding a simultaneous cognitive task in the elbow's range of movement during arm curl test in women with fibromyalgia. ( 31031226 )
2019

Variations for Fibromyalgia

Expression for Fibromyalgia

Search GEO for disease gene expression data for Fibromyalgia.

Pathways for Fibromyalgia

Pathways related to Fibromyalgia according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.47 CRH CXCL8 GRIN2D HTR2A NPY OPRM1
2
Show member pathways
13.22 CXCL8 GRIN2D IL6 NCAM1 OPRM1 POMC
3 12.39 COMT NCAM1 NPY OPRM1 POMC
4
Show member pathways
12.08 BDNF CXCL8 IGF1 IL6 TNF
5 11.86 IGF1 IL6 NCAM1 SERPINA1
6 11.84 CXCL8 IGF1 IL6
7 11.81 CXCL8 IL6 TNF
8 11.79 CXCL8 IL6 TNF
9 11.78 BDNF CXCL8 IL6 TNF
10 11.77 CRH CXCL8 POMC
11 11.76 CXCL8 IL6 TNF
12 11.71 CXCL8 IL6 OPRM1 POMC TNF
13 11.7 CXCL8 IL6 POMC
14 11.68 BDNF IGF1 NCAM1
15 11.66 CXCL8 IL6 TNF
16 11.64 IL6 NCAM1 TNF
17 11.59 NPY POMC TNF
18
Show member pathways
11.53 CXCL8 IL6 TNF
19 11.47 BDNF IGF1 IL6 TNF
20 11.45 CXCL8 IL6 TNF
21 11.39 CXCL8 IL6 TNF
22 11.38 CXCL8 IL6 TNF
23 11.38 BDNF CXCL8 HTR2A HTR3A IL6 SLC6A4
24 11.32 IGF1 IL6 TNF
25 11.15 CXCL8 IGF1 IL6 SERPINA1 TNF
26 10.99 HTR2A HTR3A SLC6A4
27 10.92 BDNF CXCL8 IGF1 IL6 TNF
28 10.74 CRP CXCL8 IL6 TNF
29 10.39 CRH POMC

GO Terms for Fibromyalgia

Cellular components related to Fibromyalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.85 BDNF CRH CRP CXCL8 IGF1 IL6
2 axon GO:0030424 9.72 BDNF COMT HTR2A HTR3A OPRM1
3 extracellular region GO:0005576 9.7 BDNF CRH CRP CXCL8 IGF1 IL6
4 integral component of presynaptic membrane GO:0099056 9.56 HTR2A HTR3A OPRM1 SLC6A4
5 integral component of postsynaptic membrane GO:0099055 8.92 HTR2A HTR3A OPRM1 SLC6A4

Biological processes related to Fibromyalgia according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.92 CRH CRP CXCL8 IL6 TNF
2 chemical synaptic transmission GO:0007268 9.89 CRH HTR2A HTR3A NPY
3 response to drug GO:0042493 9.83 COMT CRH SLC6A4 HTR2A TSPO
4 cellular response to lipopolysaccharide GO:0071222 9.81 CXCL8 IL6 TNF TSPO
5 neuropeptide signaling pathway GO:0007218 9.79 NPY OPRM1 POMC
6 defense response to Gram-positive bacterium GO:0050830 9.78 CRP IL6 TNF
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.77 HTR2A IGF1 IL6
8 cytokine-mediated signaling pathway GO:0019221 9.77 CXCL8 IL6 OPRM1 POMC TNF
9 memory GO:0007613 9.76 BDNF HTR2A SLC6A4
10 excitatory postsynaptic potential GO:0060079 9.74 GRIN2D HTR3A OPRM1
11 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007187 9.73 HTR2A NPY OPRM1
12 positive regulation of gene expression GO:0010628 9.73 CRH CRP IGF1 IL6 SLC6A4 TNF
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.72 IGF1 IL6 TNF
14 response to cocaine GO:0042220 9.65 CRH HTR3A OPRM1
15 acute-phase response GO:0006953 9.63 CRP IL6 SERPINA1
16 serotonin receptor signaling pathway GO:0007210 9.58 HTR2A HTR3A
17 regulation of sensory perception of pain GO:0051930 9.58 COMT GRIN2D OPRM1
18 positive regulation of neuroinflammatory response GO:0150078 9.54 IL6 TNF
19 response to pain GO:0048265 9.5 COMT CRH TSPO
20 positive regulation of appetite GO:0032100 9.49 NPY OPRM1
21 positive regulation of glial cell proliferation GO:0060252 9.33 IL6 TNF TSPO
22 regulation of signaling receptor activity GO:0010469 9.17 BDNF CXCL8 IGF1 IL6 NPY POMC
23 negative regulation of lipid storage GO:0010888 9.13 CRP IL6 TNF

Molecular functions related to Fibromyalgia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.26 CRH IGF1 NPY POMC
2 serotonin binding GO:0051378 8.8 HTR2A HTR3A SLC6A4

Sources for Fibromyalgia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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