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MCID: FBR017
MIFTS: 56

Fibrosarcoma

Categories: Bone diseases, Cancer diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Fibrosarcoma

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MalaCards integrated aliases for Fibrosarcoma:

Name: Fibrosarcoma 12 74 52 58 29 54 43 15 17 71
Neoplasms, Fibrous Tissue 43 71
Fibrosarcoma of Soft Tissue 12
Fibrous Tissue Neoplasm 12
Fibrocytic Tumor 12

Characteristics:

Orphanet epidemiological data:

58
fibrosarcoma
Prevalence: <1/1000000 (Europe); Age of onset: All ages;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 33
Orphanet: 58  
Rare bone diseases


External Ids:

Disease Ontology 12 DOID:3355
SNOMED-CT 67 53654007
MESH via Orphanet 44 D005354
ICD10 via Orphanet 33 C49.9
UMLS via Orphanet 72 C0016057
Orphanet 58 ORPHA2030
UMLS 71 C0016057 C0206643 C1336021
Sources

Summaries for Fibrosarcoma

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Disease Ontology : 12 A connective tissue cancer that has material basis in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern.

MalaCards based summary : Fibrosarcoma, also known as neoplasms, fibrous tissue, is related to congenital fibrosarcoma and adult fibrosarcoma. An important gene associated with Fibrosarcoma is ETV6 (ETS Variant Transcription Factor 6), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Degradation of the extracellular matrix. The drugs Vincristine and Dactinomycin have been mentioned in the context of this disorder. Affiliated tissues include bone, lung and t cells, and related phenotypes are Reduced mammosphere formation and shRNA abundance <= 50%

Wikipedia : 74 Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective... more...

Sources

Related Diseases for Fibrosarcoma

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Diseases in the Fibrosarcoma family:

Adult Fibrosarcoma Congenital Fibrosarcoma

Diseases related to Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 545)
# Related Disease Score Top Affiliating Genes
1 congenital fibrosarcoma 34.8 VIM NTRK3 ETV6
2 adult fibrosarcoma 34.6 NTRK3 ETV6
3 infantile myofibromatosis 33.5 VIM NTRK3 ETV6
4 inflammatory myofibroblastic tumor 33.3 VIM NTRK3 ETV6
5 rheumatoid arthritis 31.3 TNF TIMP2 TIMP1 MMP9 MMP2 MALAT1
6 fasciitis 31.3 VIM TNF ETV6
7 aortic aneurysm 31.2 TIMP2 TIMP1 MMP9 MMP2
8 osteogenic sarcoma 31.2 TNF MMP9 MMP2 MALAT1 JUN
9 breast adenocarcinoma 31.2 TNF SERPINE1 PLAU MMP9 MMP2
10 cellular congenital mesoblastic nephroma 31.0 NTRK3 ETV6
11 aortic aneurysm, familial abdominal, 1 30.9 TIMP2 TIMP1 PLAU MMP9 MMP2 MMP14
12 pneumothorax 30.8 VIM TIMP2 TIMP1 MMP9 MMP2
13 theileriasis 30.7 TNF MAFB JUN
14 corneal ulcer 30.7 MMP9 MMP2 FN1
15 aortic aneurysm, familial thoracic 1 30.7 TIMP2 TIMP1 MMP9 MMP2
16 periodontitis 30.7 TNF TIMP1 MMP9 MMP2
17 grade iii astrocytoma 30.7 TIMP2 PLAU MMP9 MMP2
18 retinal detachment 30.6 TNF TIMP1 MMP9 MMP2
19 breast secretory carcinoma 30.6 NTRK3 ETV6
20 varicose veins 30.5 TNF TIMP2 TIMP1 MMP9 MMP2 FN1
21 adenocarcinoma 30.5 TIMP2 TIMP1 NTRK3 MMP9 MMP2 MALAT1
22 disseminated intravascular coagulation 30.5 TNF SERPINE1 FN1
23 gastrointestinal stromal tumor 30.4 VIM NTRK3 MMP9 MMP2
24 nasopharyngeal carcinoma 30.3 TNF MMP9 MMP2 MALAT1 JUN
25 renal cell carcinoma, nonpapillary 30.3 VIM TIMP2 MMP9 MMP2 MALAT1 JUN
26 breast cancer 30.2 VIM TNF TIMP2 TIMP1 SERPINE1 PLAU
27 myeloma, multiple 29.9 TNF MMP9 MMP2 MALAT1 MAFB MAF
28 leukemia, acute myeloid 29.9 TNF MMP9 MALAT1 JUN FN1 ETV6
29 neuroblastoma 29.9 TNF NTRK3 MMP9 MMP2 MALAT1 JUN
30 bladder cancer 29.9 TNF TIMP2 PLAU MMP9 MMP2 MALAT1
31 lung cancer susceptibility 3 29.8 TIMP2 PLAU NTRK3 MMP9 MMP2 MMP14
32 ovarian cancer 29.6 VIM TNF TIMP2 TIMP1 SERPINE1 PLAU
33 pancreatic cancer 29.6 TNF PLAU MMP9 MMP2 MMP14 MALAT1
34 liver fibrosarcoma 12.5
35 small bowel fibrosarcoma 12.5
36 heart fibrosarcoma 12.4
37 breast fibrosarcoma 12.4
38 kidney fibrosarcoma 12.4
39 central nervous system fibrosarcoma 12.4
40 conventional fibrosarcoma 12.4
41 fibrosarcoma of bone 12.3
42 pediatric fibrosarcoma 12.2
43 diaphyseal medullary stenosis with malignant fibrous histiocytoma 11.9
44 dermatofibrosarcoma protuberans 11.7
45 fibroma 11.6
46 desmoid tumor 11.6
47 chromosome 17q11.2 deletion syndrome 11.2
48 ayme-gripp syndrome 10.8 MAFK MAFG MAF
49 extracranial arteriovenous malformation 10.8 MMP9 MMP2
50 focal myositis 10.8 MMP9 MMP2

Graphical network of the top 20 diseases related to Fibrosarcoma:



Diseases related to Fibrosarcoma
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Symptoms & Phenotypes for Fibrosarcoma

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GenomeRNAi Phenotypes related to Fibrosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.5 ETV6 JUN MMP14 MMP2 TIMP1 TIMP2
2 shRNA abundance <= 50% GR00343-S 9.1 JUN MAFB MMP14 MMP2 SERPINE1 TIMP2

MGI Mouse Phenotypes related to Fibrosarcoma:

45 (show all 18)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.44 ETV6 FN1 JUN MAF MAFA MAFB
2 cardiovascular system MP:0005385 10.41 ETV6 FN1 JUN MAFB MMP14 MMP2
3 immune system MP:0005387 10.4 ETV6 FN1 JUN MAF MAFB MAFG
4 homeostasis/metabolism MP:0005376 10.39 ETV6 FN1 JUN MAF MAFA MAFB
5 hematopoietic system MP:0005397 10.37 ETV6 FN1 JUN MAFG MAFK MMP14
6 mortality/aging MP:0010768 10.36 ETV6 FN1 JUN MAF MAFB MAFG
7 behavior/neurological MP:0005386 10.35 JUN MAF MAFB MAFG MAFK MMP14
8 cellular MP:0005384 10.3 ETV6 FN1 JUN MAFB MAFG MAFK
9 nervous system MP:0003631 10.21 FN1 JUN MAF MAFB MAFG MAFK
10 integument MP:0010771 10.13 ETV6 FN1 JUN MAF MMP14 MMP9
11 craniofacial MP:0005382 10.09 FN1 MAF MAFB MMP14 MMP2 PLAU
12 muscle MP:0005369 10.09 FN1 MAFG MAFK MMP14 MMP2 MMP9
13 normal MP:0002873 10.02 ETV6 FN1 JUN MAFA MAFB MAFF
14 neoplasm MP:0002006 10.01 ETV6 FN1 MMP2 MMP9 PLAU SERPINE1
15 reproductive system MP:0005389 9.96 FN1 MAFB MAFK MMP14 MMP9 NTRK3
16 respiratory system MP:0005388 9.9 JUN MAFB MMP14 MMP2 MMP9 NTRK3
17 skeleton MP:0005390 9.61 FN1 JUN MAFB MMP14 MMP2 MMP9
18 vision/eye MP:0005391 9.28 JUN MAF MMP14 MMP2 MMP9 NTRK3
Sources

Drugs & Therapeutics for Fibrosarcoma

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Drugs for Fibrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 109)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
2
Dactinomycin Approved, Investigational Phase 3 50-76-0 457193 2019
3
Lenograstim Approved, Investigational Phase 3 135968-09-1
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
6
Epirubicin Approved Phase 3 56420-45-2 41867
7
Ifosfamide Approved Phase 2, Phase 3 3778-73-2 3690
8
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
9
Mechlorethamine Approved, Investigational Phase 2, Phase 3 51-75-2 4033
10
Daunorubicin Approved Phase 2, Phase 3 20830-81-3 30323
11
Doxorubicin Approved, Investigational Phase 2, Phase 3 23214-92-8 31703
12
Trabectedin Approved, Investigational Phase 2, Phase 3 114899-77-3 108150
13
Histamine Approved, Investigational Phase 3 51-45-6 774
14
Cyproheptadine Approved Phase 3 129-03-3 2913
15 Etoposide phosphate Phase 3
16 Tubulin Modulators Phase 3
17 Antirheumatic Agents Phase 3
18 Antimitotic Agents Phase 3
19
Isophosphamide mustard Phase 2, Phase 3 0
20 Alkylating Agents Phase 2, Phase 3
21 Anti-Bacterial Agents Phase 2, Phase 3
22
Liposomal doxorubicin Phase 2, Phase 3 31703
23 Antibiotics, Antitubercular Phase 2, Phase 3
24 Neurotransmitter Agents Phase 3
25 Histamine Antagonists Phase 3
26 Anti-Allergic Agents Phase 3
27
Histamine Phosphate Phase 3 51-74-1 65513
28 Histamine H1 Antagonists Phase 3
29 Dermatologic Agents Phase 3
30 Gastrointestinal Agents Phase 3
31
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
32
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
33
Temozolomide Approved, Investigational Phase 2 85622-93-1 5394
34
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
35
Romidepsin Approved, Investigational Phase 2 128517-07-7 5352062
36
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
37
Bevacizumab Approved, Investigational Phase 2 216974-75-3
38
Paclitaxel Approved, Vet_approved Phase 1, Phase 2 33069-62-4 36314
39
Topotecan Approved, Investigational Phase 2 123948-87-8, 119413-54-6 60700
40
Clotrimazole Approved, Vet_approved Phase 2 23593-75-1 2812
41
Miconazole Approved, Investigational, Vet_approved Phase 2 22916-47-8 4189
42
Sirolimus Approved, Investigational Phase 2 53123-88-9 5284616 6436030 46835353
43
Vinorelbine Approved, Investigational Phase 1, Phase 2 71486-22-1 60780 44424639
44
Estramustine Approved, Investigational Phase 1, Phase 2 2998-57-4 18140 259331
45
Sorafenib Approved, Investigational Phase 1, Phase 2 284461-73-0 216239 406563
46
Idarubicin Approved Phase 1, Phase 2 58957-92-9 42890
47
Cytarabine Approved, Experimental, Investigational Phase 1, Phase 2 147-94-4, 65-46-3 6253
48
Dacarbazine Approved, Investigational Phase 2 4342-03-4 5351166
49
Entrectinib Approved, Investigational Phase 1, Phase 2 1108743-60-7 25141092
50
Pembrolizumab Approved Phase 2 1374853-91-4

Interventional clinical trials:

(show top 50) (show all 89)
# Name Status NCT ID Phase Drugs
1 A Phase III Randomized Study of Preoperative Radiotherapy Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcoma (RPS) Unknown status NCT01344018 Phase 3
2 Localized Non-Rhabdomyosarcoma Soft Tissue Sarcomas Unknown status NCT00334854 Phase 3 doxorubicin hydrochloride;ifosfamide
3 Risk-Based Treatment for Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS) in Patients Under 30 Years of Age Unknown status NCT00346164 Phase 3 doxorubicin hydrochloride;ifosfamide
4 Phase III Study of The Role of Barrier Resection in Local Control in Treatment of Extremity Soft Tissue Sarcomas Unknown status NCT02120768 Phase 3
5 Randomised Trial of Post-Operative Radiotherapy Given to Adult Patients With Extremity Soft Tissue Sarcoma [VORTEX] Completed NCT00423618 Phase 3
6 A Phase III Randomized Study of Preoperative Radiation Plus Surgery Versus Surgery Alone for Patients With Retroperitoneal Sarcomas (RPS) Completed NCT00091351 Phase 3
7 Randomized Phase III Trial of Two Investigational Schedules of Ifosfamide vs. Standard Dose Doxorubicin in Patients With Advanced or Metastatic Soft Tissue Sarcoma Completed NCT00003212 Phase 3 doxorubicin hydrochloride;ifosfamide
8 Randomized Study Comparing Neoadjuvant Chemotherapy Etoposide + Ifosfamide + Adriamycin (EIA) Combined With Regional Hyperthermia (RHT) Versus Neoadjuvant Chemotherapy Alone in the Treatment of High-Risk Soft Tissue Sarcomas in Adults Completed NCT00003052 Phase 3 doxorubicin hydrochloride;etoposide;ifosfamide
9 METASTASECTOMY AND CHEMOTHERAPY FOR LUNG METASTASES FROM SOFT TISSUE SARCOMA: A RANDOMIZED PHASE III STUDY (AN INTERGROUP STUDY WITH THE SCANDINAVIAN SARCOMA GROUP) Completed NCT00002764 Phase 3 doxorubicin hydrochloride;ifosfamide
10 Randomised Trial Of Single Agent Doxorubicin Versus Doxorubicin Plus Ifosfamide In The First Line Treatment Of Advanced Or Metastatic Soft Tissue Sarcoma Completed NCT00061984 Phase 3 doxorubicin hydrochloride;ifosfamide
11 RANDOMISED TRIAL OF ADJUVANT CHEMOTHERAPY WITH HIGH-DOSE DOXORUBICIN, IFOSFAMIDE AND LENOGRASTIM IN HIGH GRADE SOFT TISSUE SARCOMA Completed NCT00002641 Phase 3 doxorubicin hydrochloride;ifosfamide;isolated perfusion
12 MMT 95 Study For Rhabdomyosarcoma and Other Malignant Soft Tissue Tumors of Childhood Completed NCT00002898 Phase 3 carboplatin;cyclophosphamide;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
13 Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# 737754) Active, not recruiting NCT02180867 Phase 2, Phase 3 Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride
14 TRUSTS: A Phase IIB/III Multicenter Study Comparing the Efficacy of TRabectedin Administered as a 3-Hour or 24-Hour Infusion to Doxorubicin in Patients With Advanced or Metastatic Untreated Soft Tissue Sarcoma Terminated NCT01189253 Phase 2, Phase 3 doxorubicin hydrochloride;trabectedin
15 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
16 Phase II Study on Axitinib in Advanced VEGFR and/or PDGFR Solitary Fibrous Tumor Unknown status NCT02261207 Phase 2 Axitinib
17 Randomized Phase II Study of Brostallicin (PNU-166196A) Versus Doxorubicin as First Line Chemotherapy in Patients With Advanced or Metastatic Soft Tissue Sarcoma Unknown status NCT00410462 Phase 2 brostallicin;doxorubicin hydrochloride
18 Phase II Evaluation of Temodal (Temozolomide, Schering) in Previously Treated Advanced Sarcomas Unknown status NCT00003718 Phase 2 temozolomide
19 A Phase I/ II Clinical Trial of MDV9300 (Pidilizumab) in Diffuse Intrinsic Pontine Glioma Unknown status NCT01952769 Phase 1, Phase 2
20 A Phase 2 Study of AZD0530 in Recurrent or Metastatic Soft Tissue Sarcoma Completed NCT00659360 Phase 2 saracatinib
21 Phase II Open-Label Study of Sunitinib Malate (SU011248) in Adult Patients With Metastatic and/or Surgically Unresectable Soft Tissue Sarcoma Completed NCT00400569 Phase 2 Sunitinib Malate (SU011248)
22 Phase II Study of Imatinib Mesylate in Patients With Life Threatening Malignant Rare Diseases Completed NCT00154388 Phase 2 Imatinib mesylate
23 A Phase II Study of Imatinib (NSC-716051) in Patients With Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans Completed NCT00084630 Phase 2 imatinib mesylate
24 A Phase 2 Study of Intravenous REOLYSIN® (Wild-Type Reovirus) in the Treatment of Patients With Bone and Soft Tissue Sarcomas Metastatic to the Lung Completed NCT00503295 Phase 2
25 A Phase II Study of Single Agent Depsipeptide (FK228) in Metastatic or Unresectable Soft Tissue Sarcomas Completed NCT00112463 Phase 2 romidepsin
26 Phase II Study on ET-743 in Advanced Soft Tissue Sarcomas of the Adult Completed NCT00003939 Phase 2 trabectedin
27 Myeloablative Chemotherapy With Stem Cell Rescue for Rare Poor-Prognosis Cancers Completed NCT00141765 Phase 2
28 Exatecan As Second-Line Treatment In Advanced Adult Soft Tissue Sarcoma: A Phase II - Study Of The EORTC Soft Tissue And Bone Sarcoma Group Completed NCT00041236 Phase 2 exatecan mesylate
29 Phase II Study of Glivec (Imatinib) in Locally Advanced and/or Metastatic Soft Tissue Sarcomas Expressing the t(17;22)(q22;q13) Translocation Resulting in a COL1A1/PDGF-beta Fusion Protein i.e. DermatoFibroSarcoma Protuberans (DFSP) and Giant Cell Fibroblastoma (GCF) Completed NCT00085475 Phase 2 imatinib mesylate
30 Efficacy And Safety Study Of Brostallicin In Patients With Locally Advanced Or Metastatic Soft Tissue Sarcoma Failing One Prior Chemotherapy Treatment Completed NCT00041249 Phase 2 brostallicin
31 Phase II Trial of Gleevec (Formerly Known as STI571) in Patients With Soft Tissue and Bone Sarcomas: A Multi-Disciplinary Trial of the North American Sarcoma Study Group of the Connective Tissue Oncology Society Completed NCT00031915 Phase 2 imatinib mesylate
32 A Phase II Study of Intravenous TZT-1027, Administered Weekly Times Two, Every Three Weeks, to Patients With Advanced or Metastatic Soft Tissue Sarcomas (STS) With Prior Exposure to Anthracycline-Based Chemotherapy Completed NCT00064220 Phase 2 soblidotin
33 A Phase II Study Of Perifosine (D-21266) In Patients With Previously Untreated Metastatic Or Locally Advanced Soft Tissue Sarcoma Completed NCT00053794 Phase 2 perifosine
34 A Phase II Study of Neoadjuvant Bevacizumab and Radiation Therapy for Resectable Soft Tissue Sarcomas Completed NCT00356031 Phase 2 Bevacizumab
35 A Phase 1/2, Multicenter, Open-label, Dose-finding Study to Assess the Safety, Tolerability, and Preliminary Efficacy of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent or Refractory Solid Tumors. Completed NCT01962103 Phase 1, Phase 2 nab-paclitaxel;nab-paclitaxel
36 Multicenter Parallel Phase II Trial of BI 2536 Administered as One Hour IV Infusion Every 3 Weeks in Defined Cohorts of Patients With Various Solid Tumors. A New Drug Screening Program of the EORTC Network of Core Institutions (NOCI) Completed NCT00526149 Phase 2 BI 2536
37 Dose Finding and Phase II Study of STI 571 in Advanced Soft Tissue Sarcoma Completed NCT00006357 Phase 1, Phase 2 imatinib mesylate
38 Myeloablative Chemotherapy With Bone Marrow Rescue For Rare Poor-Prognosis Cancers Completed NCT00002515 Phase 2 carboplatin;thiotepa;topotecan hydrochloride
39 A Phase II Study of Cixutumumab (IMC-A12) in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors Completed NCT01614795 Phase 2 Temsirolimus
40 A Multicenter Phase II Study of Continuous Dosing of Sunitinib (Sutent®, SU11248) in Non-GIST Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
41 A Phase 1B/II Study of GDC-0449 (NSC 747691) in Combination With RO4929097, a Gamma-Secretase Inhibitor (GSI) in Advanced/Metastatic Sarcomas Completed NCT01154452 Phase 1, Phase 2 Gamma-Secretase Inhibitor RO4929097;Vismodegib
42 A Phase I/II Study of Paclitaxel, Estramustine Phosphate, and Vinorelbine (PaclEVin) Completed NCT00004105 Phase 1, Phase 2 estramustine phosphate sodium;paclitaxel;vinorelbine ditartrate
43 MMT 98 Study For Metastatic Disease Rhabdomyosarcoma And Other Malignant Soft Tissue Sarcoma Of Childhood Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
44 Phase I-II Study of Idarubicin, Cytarabine, and Sorafenib (BAY43-9006), an Oral Vascular Endothelial Growth Factor (VEGF), Rapidly Accelerated Fibrosarcoma (RAF) and FMS-like Tyrosine Kinase 3 (FLT3), in Patients With High-risk MDS and AML Completed NCT00542971 Phase 1, Phase 2 Idarubicin;Sorafenib;Ara-C
45 A Phase II Study of BAY 43-9006 (Sorafenib) in Combination With Cetuximab (Erbitux ) in EGFR Expressing Metastatic Colorectal Cancer (CRC) Completed NCT00326495 Phase 2 Cetuximab;BAY 43-9006
46 Solitary Fibrous Tumor: Phase II Study on Trabectedin Versus Adriamycin Plus Dacarbazine in Advanced Patients Recruiting NCT03023124 Phase 2 Trabectedin;Adriamycin;Dacarbazine
47 ERibulin in Advanced Solitary Fibrous Tumor, an ItaliaN Sarcoma Group Phase II Study (ERASING) Recruiting NCT03840772 Phase 2 Eribulin
48 A Phase 1/2, Open-Label, Dose-Escalation And Expansion Study Of Entrectinib (Rxdx-101) In Pediatrics With Locally Advanced Or Metastatic Solid Or Primary CNS Tumors And/Or Who Have No Satisfactory Treatment Options Recruiting NCT02650401 Phase 1, Phase 2 Entrectinib
49 A Phase 1/2 Study of the Oral RET Inhibitor LOXO 292 in Pediatric Patients With Advanced RET-Altered Solid or Primary Central Nervous System Tumors Recruiting NCT03899792 Phase 1, Phase 2 LOXO-292
50 A Non-Inferiority Study of Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma Recruiting NCT02584309 Phase 2 Dexrazoxane;Doxorubicin

Search NIH Clinical Center for Fibrosarcoma

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Dacarbazine

Cochrane evidence based reviews: fibrosarcoma

Sources

Genetic Tests for Fibrosarcoma

About this section

Genetic tests related to Fibrosarcoma:

# Genetic test Affiliating Genes
1 Fibrosarcoma (disease) 29
Sources

Anatomical Context for Fibrosarcoma

About this section

MalaCards organs/tissues related to Fibrosarcoma:

40
Bone, Lung, T Cells, Breast, Endothelial, Liver, Skin
Sources

Publications for Fibrosarcoma

About this section

Articles related to Fibrosarcoma:

(show top 50) (show all 9746)
# Title Authors PMID Year
1
Inhibition of histone deacetylase attenuates hypoxia-induced migration and invasion of cancer cells via the restoration of RECK expression. 54 61
20442303 2010
2
Biosynthesis and recovery of selenium nanoparticles and the effects on matrix metalloproteinase-2 expression. 61 54
20408816 2010
3
TRAIL and doxorubicin combination induces proapoptotic and antiangiogenic effects in soft tissue sarcoma in vivo. 54 61
20406839 2010
4
The benzoylurea derivative F13 inhibits cell growth, migration and invasion through inducing expression of ERK1/2-mediated RECK in fibrosarcoma HT-1080 cells. 54 61
20051826 2010
5
The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner. 54 61
19913614 2010
6
The role of MT2-MMP in cancer progression. 61 54
20117087 2010
7
Timp-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells. 61 54
19551841 2010
8
Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone--an array comparative genomic hybridization study. 54 61
19862822 2010
9
Inhibition of the expression on MMP-2, 9 and morphological changes via human fibrosarcoma cell line by 6,6'-bieckol from marine alga Ecklonia cava. 61 54
20132738 2010
10
Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression. 54 61
19961596 2009
11
Regulation of homotypic cell-cell adhesion by branched N-glycosylation of N-cadherin extracellular EC2 and EC3 domains. 54 61
19846557 2009
12
VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. 54 61
19910495 2009
13
Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells. 61 54
19785038 2009
14
bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells. 54 61
19577615 2009
15
Stabilization of anaphase midzone microtubules is regulated by Rho during cytokinesis in human fibrosarcoma cells. 61 54
19576212 2009
16
[Mechanism of endothelial Rho/Rho kinase in extravascular migration of fibrosarcoma cell]. 54 61
19968078 2009
17
Identification of integrins alpha6 and beta7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells. 54 61
19405119 2009
18
PI3K/Akt activity has variable cell-specific effects on expression of HIF target genes, CA9 and VEGF, in human cancer cell lines. 61 54
19342157 2009
19
Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases. 54 61
19571375 2009
20
Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence. 61 54
19478560 2009
21
Autotaxin promotes the expression of matrix metalloproteinase-3 via activation of the MAPK cascade in human fibrosarcoma HT-1080 cells. 61 54
19212832 2009
22
The inhibitory mechanism of a novel cationic glucosamine derivative against MMP-2 and MMP-9 expressions. 54 61
19375915 2009
23
A novel mode of cell detachment from fibrillar fibronectin matrix under shear. 61 54
19401337 2009
24
LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. 54 61
19366727 2009
25
Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates. 54 61
19234490 2009
26
[Triptolide evaluates DNA methylation level of matrix metalloproteinase 9 gene in human fibrosarcoma HT-1080 cells]. 54 61
19526795 2009
27
Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. 54 61
18495463 2009
28
Chondroitin sulfate A regulates fibrosarcoma cell adhesion, motility and migration through JNK and tyrosine kinase signaling pathways. 54 61
19368127 2009
29
Mapping proteolytic cancer cell-extracellular matrix interfaces. 61 54
18600304 2009
30
Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes. 61 54
18802920 2008
31
Use of the Rad51 promoter for targeted anti-cancer therapy. 61 54
19106292 2008
32
TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcoma. 54 61
19077262 2008
33
Transcription factors as therapeutic targets for diabetes. 61 54
18851698 2008
34
Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver. 61 54
18681831 2008
35
Glucose regulation of insulin gene expression in pancreatic beta-cells. 54 61
18778246 2008
36
Mapping local matrix remodeling induced by a migrating tumor cell using three-dimensional multiple-particle tracking. 54 61
18641063 2008
37
Flavonoid glycosides isolated from Salicornia herbacea inhibit matrix metalloproteinase in HT1080 cells. 61 54
18715546 2008
38
Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells. 61 54
18627313 2008
39
Effects of lentivirus-mediated HIF-1alpha knockdown on hypoxia-related cisplatin resistance and their dependence on p53 status in fibrosarcoma cells. 61 54
18421307 2008
40
Wdnm1-like, a new adipokine with a role in MMP-2 activation. 61 54
18492766 2008
41
Efrapeptin J, a new down-regulator of the molecular chaperone GRP78 from a marine Tolypocladium sp. 61 54
18667784 2008
42
Global and focused transcriptional profiling of small molecule aminopeptidase N inhibitor reveals its mechanism of angiogenesis inhibition. 54 61
18413233 2008
43
Fibronectin fragmentation is a feature of periodontal disease sites and diabetic foot and leg wounds and modifies cell behavior. 54 61
18454665 2008
44
Attenuation of melanoma invasion by a secreted variant of activated leukocyte cell adhesion molecule. 54 61
18483249 2008
45
Human tissue factor pathway inhibitor-2 induces caspase-mediated apoptosis in a human fibrosarcoma cell line. 61 54
18401718 2008
46
Restoration of tumor immunosurveillance via targeting of interleukin-13 receptor-alpha 2. 61 54
18451175 2008
47
A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness. 61 54
18392131 2008
48
Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock. 61 54
18283592 2008
49
Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion. 54 61
18222489 2008
50
Regulation of hyaluronan and versican deposition by growth factors in fibrosarcoma cell lines. 61 54
17980161 2008
Sources

Variations for Fibrosarcoma

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Expression for Fibrosarcoma

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Search GEO for disease gene expression data for Fibrosarcoma.
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Pathways for Fibrosarcoma

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Pathways related to Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 32)
# Super pathways Score Top Affiliating Genes
1
Response to elevated platelet cytosolic Ca2+ 65
Show member pathways
 13.26 TIMP1 SERPINE1 PLAU MAFK MAFG MAFF
2
Degradation of the extracellular matrix 65
Show member pathways
 12.67 TIMP2 TIMP1 SERPINE1 MMP9 MMP2 MMP14
3
Proteoglycans in cancer 36
12.26 TNF PLAU MMP9 MMP2 FN1
4
G-protein signaling Ras family GTPases in kinase cascades (scheme) 22
Show member pathways
 12.24 TIMP1 SERPINE1 JUN FN1
5
Transcriptional misregulation in cancer 36
12.22 PLAU MMP9 MAF ETV6
6
Colorectal Cancer Metastasis 63
12.12 TNF MMP9 MMP2 MMP14
7
Fluid shear stress and atherosclerosis 36
12.04 TNF MMP9 MMP2 JUN
8
Adhesion 4
11.97 SERPINE1 MMP9 MMP2 MMP14
9
TNF signaling pathway 36
11.93 TNF MMP9 MMP14 JUN
10
Senescence and Autophagy in Cancer 1
11.88 SERPINE1 PLAU MMP14 JUN FN1
11
Angiogenesis (CST) 4
11.81 TIMP2 TIMP1 MMP9 MMP2
12
AGE-RAGE signaling pathway in diabetic complications 36
11.8 TNF SERPINE1 MMP2 JUN FN1
13
Interleukin-4 and 13 signaling 65
11.79 VIM TNF TIMP1 MMP9 MMP2 FN1
14
Regulation of Wnt-mediated beta catenin signaling and target gene transcription 1
11.72 MMP9 MMP2 JUN
15
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.7 TNF MAF JUN
16
AGE/RAGE pathway 1
11.66 MMP9 MMP2 MMP14 JUN
17
LPA receptor mediated events 1
11.63 MMP9 MMP2 JUN
18
Matrix Metalloproteinases 1
Show member pathways
 11.63 TNF TIMP2 TIMP1 MMP9 MMP2 MMP14
19
Photodynamic therapy-induced NF-kB survival signaling 1
Show member pathways
 11.62 TNF MMP9 MMP2 JUN
20
TGF-beta Receptor Signaling (WikiPathways) 1
11.57 TNF SERPINE1 JUN
21
Lung fibrosis 1
11.57 TNF TIMP1 PLAU MMP9 MMP2
22
ATF-2 transcription factor network 1
11.54 PLAU MMP2 JUN
23
Photodynamic therapy-induced AP-1 survival signaling. 1
11.49 TNF MMP2 JUN
24
FGF signaling pathway 1
11.45 PLAU MMP9 JUN
25
Osteopontin-mediated events 1
Show member pathways
 11.45 PLAU MMP9 MMP2 JUN
26
amb2 Integrin signaling 1
11.4 TNF PLAU MMP9 MMP2 FN1
27
Validated transcriptional targets of AP1 family members Fra1 and Fra2 1
11.27 PLAU MMP9 MMP2 JUN
28
IL1 and megakaryocytes in obesity 1
11.14 TIMP2 TIMP1 MMP9
29
Tacrolimus/Cyclosporine Pathway, Pharmacodynamics 60
11.14 MAFK MAFG MAFF MAFB MAFA MAF
30
Cell adhesion_ECM remodeling 22
11.01 TIMP2 TIMP1 SERPINE1 PLAU MMP9 MMP2
31
G-protein signaling_Rap2B regulation pathway 22
10.96 VIM TNF TIMP2 TIMP1 NTRK3 JUN
32
Dissolution of Fibrin Clot 65
10.77 SERPINE1 PLAU
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GO Terms for Fibrosarcoma

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Cellular components related to Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.91 TNF TIMP2 TIMP1 SERPINE1 PLAU MMP9
2 collagen-containing extracellular matrix GO:0062023 9.72 TIMP2 SERPINE1 MMP9 MMP2 FN1
3 nuclear chromatin GO:0000790 9.7 MAFK MAFF MAFB MAFA MAF JUN
4 platelet alpha granule lumen GO:0031093 9.54 TIMP1 SERPINE1 FN1
5 extracellular matrix GO:0031012 9.43 TIMP2 TIMP1 MMP9 MMP2 MMP14 FN1
6 host cell nucleus GO:0042025 9.17 MAFK MAFG MAFF MAFB MAFA MAF

Biological processes related to Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 regulation of transcription, DNA-templated GO:0006355 10.14 MAFK MAFG MAFF MAFB MAFA MAF
2 positive regulation of transcription by RNA polymerase II GO:0045944 10.02 TNF SERPINE1 MAFG MAFF MAFB MAFA
3 positive regulation of gene expression GO:0010628 9.93 VIM TNF NTRK3 MAFG MAF FN1
4 positive regulation of cell migration GO:0030335 9.91 PLAU NTRK3 MMP9 MMP14
5 regulation of cell proliferation GO:0042127 9.9 TNF PLAU MAFG JUN
6 blood coagulation GO:0007596 9.87 PLAU MAFK MAFG MAFF
7 angiogenesis GO:0001525 9.83 SERPINE1 MMP2 MMP14 JUN FN1
8 circadian rhythm GO:0007623 9.8 SERPINE1 NTRK3 JUN
9 cytokine-mediated signaling pathway GO:0019221 9.8 VIM TNF TIMP1 MMP9 MMP2 FN1
10 ephrin receptor signaling pathway GO:0048013 9.79 NTRK3 MMP9 MMP2
11 positive regulation of smooth muscle cell proliferation GO:0048661 9.73 TNF MMP2 JUN
12 response to cytokine GO:0034097 9.72 TIMP2 TIMP1 JUN
13 response to organic substance GO:0010033 9.71 TNF TIMP2 TIMP1 JUN
14 response to hormone GO:0009725 9.7 TIMP2 TIMP1 MMP14
15 collagen catabolic process GO:0030574 9.69 MMP9 MMP2 MMP14
16 cellular response to reactive oxygen species GO:0034614 9.65 MMP9 MMP2 JUN
17 response to amyloid-beta GO:1904645 9.63 MMP9 MMP2
18 extracellular matrix organization GO:0030198 9.63 TNF SERPINE1 MMP9 MMP2 MMP14 FN1
19 lens fiber cell differentiation GO:0070306 9.62 NTRK3 MAF
20 tissue remodeling GO:0048771 9.61 MMP2 MMP14
21 negative regulation of metallopeptidase activity GO:1905049 9.59 TIMP2 TIMP1
22 negative regulation of vascular wound healing GO:0061044 9.58 TNF SERPINE1
23 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.58 TIMP2 TIMP1
24 positive regulation of vascular smooth muscle cell proliferation GO:1904707 9.56 TNF MMP9 MMP2 JUN
25 regulation of epidermal cell differentiation GO:0045604 9.49 MAFG MAFF
26 endodermal cell differentiation GO:0035987 9.26 MMP9 MMP2 MMP14 FN1
27 extracellular matrix disassembly GO:0022617 9.02 TIMP2 TIMP1 MMP9 MMP2 MMP14

Molecular functions related to Fibrosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.36 VIM TNF TIMP2 TIMP1 SERPINE1 PLAU
2 DNA-binding transcription factor activity GO:0003700 9.97 MAFK MAFG MAFF MAFB MAFA MAF
3 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.92 MAFK MAFG MAFF MAFB MAFA MAF
4 sequence-specific DNA binding GO:0043565 9.86 MAFK MAFG MAFF MAFB MAFA MAF
5 DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 9.7 MAFG MAFF MAFB MAFA MAF JUN
6 endopeptidase activity GO:0004175 9.61 MMP9 MMP2 MMP14
7 protease binding GO:0002020 9.35 TNF TIMP2 TIMP1 SERPINE1 FN1
8 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.23 MAFK MAFG MAFF MAFB MAFA MAF
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Sources for Fibrosarcoma

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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