Fibrosarcoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: FBR017 MIFTS: 55	Fibrosarcoma Categories: Bone diseases, Cancer diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Fibrosarcoma

MalaCards integrated aliases for Fibrosarcoma:

Name: Fibrosarcoma ¹¹ ¹⁹ ⁵⁸ ⁷⁵ ²⁸ ⁵³ ⁴³ ¹⁴ ¹⁶ ⁷¹

Neoplasms, Fibrous Tissue ⁴³ ⁷¹

Fibrosarcoma of Soft Tissue ¹¹

Fibrous Tissue Neoplasm ¹¹

Fibrocytic Tumor ¹¹

Characteristics:

Prevelance:

<1/1000000 (Europe) ⁵⁸

Age Of Onset:

All ages ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Bone diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Neoplasms

Malignant neoplasms of mesothelial and soft tissue

Malignant neoplasm of other connective and soft tissue

Malignant neoplasm: Connective and soft tissue, unspecified

Orphanet: ⁵⁸

Rare bone diseases

External Ids:

Disease Ontology ¹¹ DOID:3355

MeSH ⁴³ D005354 D018218

NCIt ⁴⁹ C3043 C6605 C7075

SNOMED-CT ⁶⁸ 443250000

MESH via Orphanet ⁴⁴ D005354

ICD10 via Orphanet ³² C49.9

UMLS via Orphanet ⁷² C0016057

Orphanet ⁵⁸ ORPHA2030

EFO ¹⁶ EFO_0002087

UMLS ⁷¹ C0016057 C0206643 C1336021

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Summaries for Fibrosarcoma

Disease Ontology: ¹¹ A connective tissue cancer that has material basis in fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern.

MalaCards based summary: Fibrosarcoma, also known as neoplasms, fibrous tissue, is related to adult fibrosarcoma and kidney fibrosarcoma. An important gene associated with Fibrosarcoma is ETV6 (ETS Variant Transcription Factor 6), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Response to elevated platelet cytosolic Ca2+. The drugs Prednisolone phosphate and Prednisolone acetate have been mentioned in the context of this disorder. Affiliated tissues include bone, endothelial and bone marrow, and related phenotypes are shRNA abundance <= 50% and Reduced mammosphere formation

GARD: ¹⁹ A fibroblastic sarcoma is a malignant tumor derived from fibrous connective tissue and characterized by immature proliferating fibroblasts or undifferentiated anaplastic spindle cells.

Wikipedia: ⁷⁵ Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour derived from fibrous connective... more...

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Related Diseases for Fibrosarcoma

Diseases in the Fibrosarcoma family:

Adult Fibrosarcoma

Congenital Fibrosarcoma

Diseases related to Fibrosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 620)

#	Related Disease	Score	Top Affiliating Genes
1	adult fibrosarcoma	32.5	NTRK3 ETV6
2	kidney fibrosarcoma	32.4	NTRK3 ETV6
3	fibroma	32.0	VIM MALAT1 FN1
4	nephroma	31.2	VIM NTRK3 ETV6
5	spindle cell sarcoma	31.1	VIM NTRK3 ETV6
6	fasciitis	31.0	VIM TNF ETV6
7	osteogenic sarcoma	30.9	MMP9 MMP2 MALAT1 JUN
8	aortic aneurysm	30.9	TNF TIMP2 TIMP1 SERPINE1 MMP9 MMP2
9	cellular congenital mesoblastic nephroma	30.8	NTRK3 ETV6
10	breast adenocarcinoma	30.7	TNF NTRK3 MMP9 MMP2 JUN FN1
11	vascular disease	30.6	TNF TIMP2 TIMP1 SERPINE1 MMP9 MMP2
12	aortic aneurysm, familial abdominal, 1	30.6	TNF TIMP2 TIMP1 SERPINE1 PLAU MMP9
13	disseminated intravascular coagulation	30.5	TNF SERPINE1 FN1
14	pneumothorax	30.5	VIM TIMP2 TIMP1 MMP9 MMP2
15	breast secretory carcinoma	30.4	NTRK3 ETV6
16	breast cancer	30.4	VIM TNF TIMP2 TIMP1 SERPINE1 PLAU
17	arthropathy	30.3	TNF TIMP1 MMP2
18	periodontitis	30.3	TNF TIMP1 MMP9 MMP2
19	hyperglycemia	30.3	TNF SERPINE1 MALAT1 JUN
20	corneal ulcer	30.3	TNF MMP9 MMP2 FN1
21	anaplastic astrocytoma	30.3	TIMP2 PLAU MMP9 MMP2
22	retinal detachment	30.3	VIM TNF TIMP1 MMP9 MMP2
23	urinary tract obstruction	30.2	TNF SERPINE1 FN1
24	varicose veins	30.2	TNF TIMP2 TIMP1 MMP9 MMP2 FN1
25	melanoma	30.2	VIM TNF TIMP2 TIMP1 PLAU MMP9
26	connective tissue disease	30.1	TNF TIMP1 MMP9 MMP2 JUN FN1
27	aortic aneurysm, familial thoracic 1	30.1	TNF TIMP2 TIMP1 SERPINE1 MMP9 MMP2
28	epithelial-myoepithelial carcinoma	30.1	NTRK3 ETV6
29	monocytic leukemia	30.1	TNF MMP9 JUN
30	renal cell carcinoma, nonpapillary	30.1	VIM TNF TIMP2 MMP9 MMP2 MALAT1
31	glioma	30.1	TIMP2 PLAU NTRK3 MMP9 MMP2 MALAT1
32	neuroblastoma	30.0	TNF NTRK3 MMP9 MMP2 MALAT1 JUN
33	liver cirrhosis	30.0	TNF TIMP2 TIMP1 MALAT1
34	leukemia, acute myeloid	30.0	TNF MMP9 MALAT1 JUN FN1 ETV6
35	bladder cancer	30.0	TNF TIMP2 PLAU MMP9 MMP2 MMP14
36	adenocarcinoma	29.9	TIMP2 TIMP1 MMP9 MMP2 MALAT1
37	high grade glioma	29.9	TIMP2 MMP9 MMP2 MMP14 MALAT1
38	lung cancer susceptibility 3	29.8	PLAU MMP9 MMP2 MALAT1 JUN
39	rheumatoid arthritis	29.8	TNF TIMP2 TIMP1 MMP9 MMP2 MMP14
40	pancreatic cancer	29.7	VIM TNF TIMP1 PLAU MMP9 MMP2
41	gastric cancer	29.7	TNF TIMP2 TIMP1 PLAU MMP9 MMP2
42	ovarian cancer	29.7	VIM TNF TIMP2 TIMP1 SERPINE1 PLAU
43	prostate cancer	29.7	VIM TNF TIMP2 TIMP1 SERPINE1 PLAU
44	congenital fibrosarcoma	11.4
45	small bowel fibrosarcoma	11.4
46	heart fibrosarcoma	11.3
47	liver fibrosarcoma	11.3
48	diaphyseal medullary stenosis with malignant fibrous histiocytoma	11.3
49	breast fibrosarcoma	11.3
50	childhood fibrosarcoma	11.2

Graphical network of the top 20 diseases related to Fibrosarcoma:

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Symptoms & Phenotypes for Fibrosarcoma

GenomeRNAi Phenotypes related to Fibrosarcoma according to GeneCards Suite gene sharing:

²⁵

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	shRNA abundance <= 50%	GR00343-S	9.43	JUN MAFB MMP14 MMP2 SERPINE1 TIMP2
2	Reduced mammosphere formation	GR00396-S	9.17	ETV6 JUN MMP14 MMP2 TIMP1 TIMP2

MGI Mouse Phenotypes related to Fibrosarcoma:

⁴⁵ (show all 21)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	10.45	FN1 JUN MAF MAFB MAFG MAFK
2	homeostasis/metabolism	MP:0005376	10.45	ETV6 FN1 JUN MAF MAFA MAFB
3	growth/size/body region	MP:0005378	10.44	ETV6 FN1 JUN MAF MAFA MAFB
4	normal	MP:0002873	10.37	ETV6 FN1 JUN MAFA MAFB MAFF
5	immune system	MP:0005387	10.36	ETV6 FN1 JUN MAF MAFB MAFG
6	cardiovascular system	MP:0005385	10.35	ETV6 FN1 JUN MAF MAFB MMP14
7	cellular	MP:0005384	10.27	ETV6 FN1 JUN MAFB MAFG MAFK
8	behavior/neurological	MP:0005386	10.27	JUN MAF MAFB MAFG MAFK MMP14
9	muscle	MP:0005369	10.26	FN1 MAFG MAFK MMP14 MMP2 MMP9
10	renal/urinary system	MP:0005367	10.22	ETV6 MAF MAFA MAFB MMP14 MMP2
11	endocrine/exocrine gland	MP:0005379	10.22	ETV6 JUN MAF MAFA MAFB MMP14
12	neoplasm	MP:0002006	10.2	ETV6 FN1 MMP2 MMP9 PLAU SERPINE1
13	reproductive system	MP:0005389	10.15	FN1 MAF MAFB MAFK MMP14 MMP2
14	respiratory system	MP:0005388	10.14	JUN MAFB MMP14 MMP2 MMP9 NTRK3
15	no phenotypic analysis	MP:0003012	10.13	ETV6 JUN MAFA MALAT1 MMP14 NTRK3
16	craniofacial	MP:0005382	10.11	FN1 JUN MAF MAFB MMP14 MMP2
17	skeleton	MP:0005390	10.06	ETV6 FN1 JUN MAFB MMP14 MMP2
18	hematopoietic system	MP:0005397	10.03	ETV6 FN1 JUN MAF MAFG MAFK
19	vision/eye	MP:0005391	9.96	JUN MAF MMP14 MMP2 MMP9 NTRK3
20	mortality/aging	MP:0010768	9.86	ETV6 FN1 JUN MAF MAFB MAFG
21	integument	MP:0010771	9.32	ETV6 FN1 JUN MAF MMP14 MMP2

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Drugs & Therapeutics for Fibrosarcoma

Drugs for Fibrosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 72)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Prednisolone phosphate

Approved, Vet_approved

Phase 4

302-25-0

Prednisolone acetate

Approved, Vet_approved

Phase 4

52-21-1

Prednisolone

Approved, Vet_approved

Phase 4

50-24-8

4894 5755

Methylprednisolone hemisuccinate

Approved

Phase 4

2921-57-5

1875

Methylprednisolone

Approved, Vet_approved

Phase 4

83-43-2

4159 6741

Prednisolone hemisuccinate

Experimental

Phase 4

2920-86-7

4897

Methylprednisolone Acetate

Phase 4

584547

Doxorubicin

Approved, Investigational

Phase 2, Phase 3

23214-92-8

31703

Daunorubicin

Approved

Phase 2, Phase 3

20830-81-3

30323

Liposomal doxorubicin

Phase 2, Phase 3

Idarubicin

Approved

Phase 1, Phase 2

58957-92-9

42890

Sorafenib

Approved, Investigational

Phase 1, Phase 2

284461-73-0

216239

Cytarabine

Approved, Investigational

Phase 1, Phase 2

147-94-4

6253

Paclitaxel

Approved, Vet_approved

Phase 1, Phase 2

33069-62-4

36314

Sunitinib

Approved, Investigational

Phase 2

557795-19-4

5329102

Sirolimus

Approved, Investigational

Phase 2

53123-88-9

5284616 6436030

Miconazole

Approved, Investigational, Vet_approved

Phase 2

22916-47-8

4189

Clotrimazole

Approved, Vet_approved

Phase 2

23593-75-1

2812

Carboplatin

Approved

Phase 2

41575-94-4

10339178 38904

Thiotepa

Approved, Investigational

Phase 2

52-24-4

5453

Bevacizumab

Approved, Investigational

Phase 2

216974-75-3

135329020

Romidepsin

Approved, Investigational

Phase 2

128517-07-7

5352062

Gemcitabine

Approved

Phase 2

95058-81-4, 122111-03-9

60750

Axitinib

Approved, Investigational

Phase 2

319460-85-0

6450551

Trabectedin

Approved, Investigational

Phase 2

114899-77-3

108150

Dacarbazine

Approved, Investigational

Phase 2

4342-03-4

2942 5351166

Dexrazoxane

Approved, Withdrawn

Phase 2

24584-09-6

71384

Topotecan

Approved, Investigational

Phase 1, Phase 2

123948-87-8, 119413-54-6

60699 60700

Ifosfamide

Approved

Phase 2

3778-73-2

3690

Cyclophosphamide

Approved, Investigational

Phase 2

50-18-0, 6055-19-2

2907

Mechlorethamine

Approved, Investigational

Phase 2

51-75-2

4033

Etoposide

Approved

Phase 2

33419-42-0

36462

Lenograstim

Approved, Investigational

Phase 2

135968-09-1

Coenzyme M

Approved, Investigational

Phase 2

3375-50-6

598 23662354

Vincristine

Approved, Investigational

Phase 2

2068-78-2, 57-22-7

5978

Dactinomycin

Approved, Investigational

Phase 2

50-76-0

2019 457193

D-Tyrosine

Approved, Experimental, Investigational, Nutraceutical

Phase 1, Phase 2

133585-56-5, 60-18-4, 556-02-5

1153 6057

Saracatinib

Investigational

Phase 2

379231-04-6

10302451

Palifosfamide

Investigational

Phase 2

31645-39-3

100427

Immunoglobulins

Phase 2

Antibodies, Monoclonal

Phase 2

Antibodies

Phase 2

Antiviral Agents

Phase 1, Phase 2

Endothelial Growth Factors

Phase 1, Phase 2

Albumin-Bound Paclitaxel

Phase 1, Phase 2

Taxane

Phase 1, Phase 2

108169

Angiogenesis Inhibitors

Phase 2

Imatinib Mesylate

Phase 2

220127-57-1

Antineoplastic Agents, Immunological

Phase 2

Antifungal Agents

Phase 2

Interventional clinical trials:

(show all 42)

#	Name	Status	NCT ID	Phase	Drugs
1	Percutaneous Needle Fasciotomy (PNF) +/- Corticosteroid Injection for Dupuytren's Contracture (DC) Affecting Metacarpophalangeal Joints (MCP) . A Randomized Controlled Trial	Not yet recruiting	NCT05440240	Phase 4	Corticosteroid injection
2	Risk-Based Treatment for Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS) in Patients Under 30 Years of Age	Completed	NCT00346164	Phase 3	doxorubicin hydrochloride;ifosfamide
3	Pazopanib Neoadjuvant Trial in Non-Rhabdomyosarcoma Soft Tissue Sarcomas (PAZNTIS): A Phase II/III Randomized Trial of Preoperative Chemoradiation or Preoperative Radiation Plus or Minus Pazopanib (NSC# 737754)	Active, not recruiting	NCT02180867	Phase 2, Phase 3	Doxorubicin;Doxorubicin Hydrochloride;Ifosfamide;Pazopanib;Pazopanib Hydrochloride
4	Hypofractionated 5x5 Gy Radiotherapy With Sequential Doxorubicin and Ifosfamide-based Chemotherapy in Marginally Resectable Soft Tissue Sarcomas of Extremities or Trunk Wall	Unknown status	NCT03651375	Phase 2	Sequential chemotherapy - 3 courses of AI
5	Phase I-II Study of Idarubicin, Cytarabine, and Sorafenib (BAY43-9006), an Oral Vascular Endothelial Growth Factor (VEGF), Rapidly Accelerated Fibrosarcoma (RAF) and FMS-like Tyrosine Kinase 3 (FLT3), in Patients With High-risk MDS and AML	Completed	NCT00542971	Phase 1, Phase 2	Idarubicin;Sorafenib;Ara-C
6	A Phase 1/2, Multicenter, Open-label, Dose-finding Study to Assess the Safety, Tolerability, and Preliminary Efficacy of Weekly Nab-paclitaxel in Pediatric Patients With Recurrent or Refractory Solid Tumors.	Completed	NCT01962103	Phase 1, Phase 2	nab-paclitaxel
7	Phase II Open-Label Study of Sunitinib Malate (SU011248) in Adult Patients With Metastatic and/or Surgically Unresectable Soft Tissue Sarcoma	Completed	NCT00400569	Phase 2	Sunitinib Malate (SU011248)
8	A Phase 2 Study of AZD0530 in Recurrent or Metastatic Soft Tissue Sarcoma	Completed	NCT00659360	Phase 2	saracatinib
9	A Phase 2 Study of Intravenous REOLYSIN® (Wild-Type Reovirus) in the Treatment of Patients With Bone and Soft Tissue Sarcomas Metastatic to the Lung	Completed	NCT00503295	Phase 2
10	A Phase II Study of Imatinib (NSC-716051) in Patients With Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans	Completed	NCT00084630	Phase 2	imatinib mesylate
11	A Phase II Study of Cixutumumab (IMC-A12) in Combination With Temsirolimus in Pediatric Patients With Recurrent or Refractory Solid Tumors	Completed	NCT01614795	Phase 2	Temsirolimus
12	Myeloablative Chemotherapy With Stem Cell Rescue for Rare Poor-Prognosis Cancers	Completed	NCT00141765	Phase 2
13	A Phase II Study of Neoadjuvant Bevacizumab and Radiation Therapy for Resectable Soft Tissue Sarcomas	Completed	NCT00356031	Phase 2	Bevacizumab
14	A Phase II Study of Single Agent Depsipeptide (FK228) in Metastatic or Unresectable Soft Tissue Sarcomas	Completed	NCT00112463	Phase 2	romidepsin
15	A Phase 1B/II Study of GDC-0449 (NSC 747691) in Combination With RO4929097, a Gamma-Secretase Inhibitor (GSI) in Advanced/Metastatic Sarcomas	Completed	NCT01154452	Phase 1, Phase 2	Gamma-Secretase Inhibitor RO4929097;Vismodegib
16	A Randomized, Double-Blind Phase II, Study of Gemcitabine Alone or in Combination With Pazopanib for Refractory Soft Tissue Sarcoma	Completed	NCT01532687	Phase 2	Gemcitabine;Gemcitabine Hydrochloride;Pazopanib;Pazopanib Hydrochloride
17	Phase II Study on Axitinib in Advanced VEGFR and/or PDGFR Solitary Fibrous Tumor	Completed	NCT02261207	Phase 2	Axitinib
18	A Phase 1/2 Study of the Oral RET Inhibitor LOXO 292 in Pediatric Patients With Advanced RET-Altered Solid or Primary Central Nervous System Tumors	Recruiting	NCT03899792	Phase 1, Phase 2	LOXO-292
19	ERibulin in Advanced Solitary Fibrous Tumor, an ItaliaN Sarcoma Group Phase II Study (ERASING)	Recruiting	NCT03840772	Phase 2	Eribulin
20	Solitary Fibrous Tumor: Phase II Study on Trabectedin Versus Adriamycin Plus Dacarbazine in Advanced Patients	Recruiting	NCT03023124	Phase 2	Trabectedin;Adriamycin;Dacarbazine
21	A Non-Inferiority Study of Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma	Active, not recruiting	NCT02584309	Phase 2	Dexrazoxane;Doxorubicin
22	Larotrectinib (LOXO-101, NSC# 788607) for Previously Untreated TRK Fusion Pediatric Solid Tumors and TRK Fusion Relapsed Pediatric Acute Leukemias	Active, not recruiting	NCT03834961	Phase 2	Larotrectinib Sulfate
23	Hypofractionated Radiotherapy With Hyperthermia in Unresectable or Marginally Resectable Soft Tissue Sarcomas	Active, not recruiting	NCT03989596	Phase 2
24	A Phase II Open-Label Trial of Pazopanib Administered as a Single Agent in Patients With Unresectable or Metastatic Solitary Fibrous Tumor (SFT) and Extraskeletal Myxoid Chondrosarcoma (EMC)	Active, not recruiting	NCT02066285	Phase 2	Pazopanib
25	A Rollover Protocol to Allow for Continued Access to the LSD1 Inhibitor Seclidemstat (SP-2577)	Enrolling by invitation	NCT05266196	Phase 1, Phase 2	Seclidemstat
26	A Pilot Phase II Study for Children With Infantile Fibrosarcoma	Terminated	NCT00072280	Phase 2	cyclophosphamide;etoposide;ifosfamide;vincristine sulfate
27	S9624: Phase II Study of Ifosfamide in Patients With Aggressive Meningeal Tumors	Terminated	NCT00003292	Phase 2	ifosfamide
28	A Phase 1 Study of Doxorubicin and A12 in Advanced Soft Tissue Sarcoma	Completed	NCT00720174	Phase 1	Doxorubicin Hydrochloride
29	Phase 1 Trial of the LSD1 Inhibitor Seclidemstat (SP 2577) With and Without Topotecan and Cyclophosphamide in Patients With Relapsed or Refractory Ewing Sarcoma and Select Sarcomas	Recruiting	NCT03600649	Phase 1	Seclidemstat;Cyclophosphamide;Topotecan
30	A Phase 1B Study of Ribociclib in Combination With Doxorubicin in Advanced Soft Tissue Sarcomas	Active, not recruiting	NCT03009201	Phase 1	Doxorubicin Hydrochloride;Ribociclib
31	A Phase I Study of Nivolumab and Intratumoral BO 112 for Resectable Soft Tissue Sarcoma	Active, not recruiting	NCT04420975	Phase 1
32	A Phase I Trial of Lenvatinib (Multi-kinase Inhibitor) and Capecitabine (Anti-metabolite) in Patients With Advanced Malignancies	Withdrawn	NCT02915172	Phase 1	Lenvatinib;Capecitabine
33	Epidemiology and Outcome of Solitary Fibrous Tumors of the Pleura. A Multicenter Study.	Unknown status	NCT01694654
34	A Comparison of Clinical Outcomes in Infantile Fibrosarcoma (IFS) Patients Treated With Larotrectinib in the Phase I/II SCOUT Study Versus (an) External Historical Cohort(s)	Completed	NCT05236257		Larotrectinib (Vitrakvi, BAY2757556);Standard of Care
35	Observational - Potentially Actionable Mutations in Archived Non-Rhabdomyosarcoma Soft Tissue Sarcomas (NRSTS)	Completed	NCT01567046
36	Multimodal Immune Characterization of RAre Soft Tissue Sarcoma - MIRAS Project From SARRA (SARcome RAre) Project of the French Sarcoma Group	Recruiting	NCT03967834
37	Staging Procedures to Diagnose Malignant Pleural Mesothelioma	Recruiting	NCT02648763
38	Chemotherapy Followed by Surgery and Neoadjuvant Hemothoracic Intensity Modified Radiation Therapy (IMRT) for Patients With Malignant Pleural Mesothelioma	Recruiting	NCT02613312
39	Surgery for Mesothelioma After Radiation Therapy "SMART" for Resectable Malignant Pleural Mesothelioma	Recruiting	NCT02613299
40	Rechallenge of Rapidly Accelerated Fibrosarcoma B-type (BRAF) +/- Mitogen-activated Extracellular Signal-regulated Kinase (MEK) Inhibitors Following an Adverse Event in Patients With Cancer	Active, not recruiting	NCT05080361		BRAF inhibitor
41	Registry For Children, Adolescents And Adults With Osteosarcoma And Biologically Related Bone Sarcomas (COSS-Registry)	Not yet recruiting	NCT05515068
42	Orbital Solitary Fibrous Tumors: Description of a Case Series and Study of the Recurrence Rate	Not yet recruiting	NCT05613244

Search NIH Clinical Center for Fibrosarcoma

Inferred drug relations via UMLS ⁷¹ / NDF-RT ⁵⁰ :

Dacarbazine

Cochrane evidence based reviews: fibrosarcoma

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Genetic Tests for Fibrosarcoma

Genetic tests related to Fibrosarcoma:

#	Genetic test	Affiliating Genes
1	Fibrosarcoma ²⁸

Sources

Anatomical Context for Fibrosarcoma

Organs/tissues related to Fibrosarcoma:

MalaCards : Bone, Endothelial, Bone Marrow, Lung, T Cells, Breast, Liver

Sources

Publications for Fibrosarcoma

Articles related to Fibrosarcoma:

(show top 50) (show all 10247)

#	Title	Authors	PMID	Year
1	TRAIL and doxorubicin combination induces proapoptotic and antiangiogenic effects in soft tissue sarcoma in vivo. ⁵³ ⁶²	Wang S...Lev D	20406839	2010
2	Biosynthesis and recovery of selenium nanoparticles and the effects on matrix metalloproteinase-2 expression. ⁵³ ⁶²	Shakibaie M...Shahverdi AR	20408816	2010
3	Inhibition of histone deacetylase attenuates hypoxia-induced migration and invasion of cancer cells via the restoration of RECK expression. ⁵³ ⁶²	Jeon HW...Lee YM	20442303	2010
4	The human alpha11 integrin promoter drives fibroblast-restricted expression in vivo and is regulated by TGF-beta1 in a Smad- and Sp1-dependent manner. ⁵³ ⁶²	Lu N...Gullberg D	19913614	2010
5	The benzoylurea derivative F13 inhibits cell growth, migration and invasion through inducing expression of ERK1/2-mediated RECK in fibrosarcoma HT-1080 cells. ⁵³ ⁶²	Jin H...Shao RG	20051826	2010
6	The role of MT2-MMP in cancer progression. ⁵³ ⁶²	Ito E...Matsuura N	20117087	2010
7	Timp-2 binding with cellular MT1-MMP stimulates invasion-promoting MEK/ERK signaling in cancer cells. ⁵³ ⁶²	Sounni NE...Strongin AY	19551841	2010
8	Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone--an array comparative genomic hybridization study. ⁵³ ⁶²	Niini T...Knuutila S	19862822	2010
9	Inhibition of the expression on MMP-2, 9 and morphological changes via human fibrosarcoma cell line by 6,6'-bieckol from marine alga Ecklonia cava. ⁵³ ⁶²	Zhang C...Kim SK	20132738	2010
10	Regulation of homotypic cell-cell adhesion by branched N-glycosylation of N-cadherin extracellular EC2 and EC3 domains. ⁵³ ⁶²	Guo HB...Pierce M	19846557	2009
11	Identification of membrane-type 1 matrix metalloproteinase tyrosine phosphorylation in association with neuroblastoma progression. ⁵³ ⁶²	Nyalendo C...Beliveau R	19961596	2009
12	Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells. ⁵³ ⁶²	Wilson LM...Gershengorn MC	19785038	2009
13	VAMP3, syntaxin-13 and SNAP23 are involved in secretion of matrix metalloproteinases, degradation of the extracellular matrix and cell invasion. ⁵³ ⁶²	Kean MJ...Coppolino MG	19910495	2009
14	bFGF induces changes in hyaluronan synthase and hyaluronidase isoform expression and modulates the migration capacity of fibrosarcoma cells. ⁵³ ⁶²	Berdiaki A...Tzanakakis GN	19577615	2009
15	Stabilization of anaphase midzone microtubules is regulated by Rho during cytokinesis in human fibrosarcoma cells. ⁵³ ⁶²	Kanada M...Uyeda TQ	19576212	2009
16	[Mechanism of endothelial Rho/Rho kinase in extravascular migration of fibrosarcoma cell]. ⁵³ ⁶²	Xin H...Han ZG	19968078	2009
17	PI3K/Akt activity has variable cell-specific effects on expression of HIF target genes, CA9 and VEGF, in human cancer cell lines. ⁵³ ⁶²	Shafee N...Stanbridge EJ	19342157	2009
18	Identification of integrins alpha6 and beta7 as c-Jun- and transformation-relevant genes in highly invasive fibrosarcoma cells. ⁵³ ⁶²	Kielosto M...Holtta E	19405119	2009
19	Paeonol exerts anti-angiogenic and anti-metastatic activities through downmodulation of Akt activation and inactivation of matrix metalloproteinases. ⁵³ ⁶²	Kim SA...Kim SH	19571375	2009
20	Pharmacologic inhibition of MEK and PI-3K converges on the mTOR/S6 pathway to decelerate cellular senescence. ⁵³ ⁶²	Demidenko ZN...Blagosklonny MV	19478560	2009
21	Autotaxin promotes the expression of matrix metalloproteinase-3 via activation of the MAPK cascade in human fibrosarcoma HT-1080 cells. ⁵³ ⁶²	Haga A...Deyashiki Y	19212832	2009
22	A novel mode of cell detachment from fibrillar fibronectin matrix under shear. ⁵³ ⁶²	Engler AJ...Schwarzbauer JE	19401337	2009
23	The inhibitory mechanism of a novel cationic glucosamine derivative against MMP-2 and MMP-9 expressions. ⁵³ ⁶²	Mendis E...Kim SK	19375915	2009
24	LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. ⁵³ ⁶²	Ying L...Rabinovitch M	19366727	2009
25	Involvement of Rac and Rho signaling in cancer cell motility in 3D substrates. ⁵³ ⁶²	Yamazaki D...Takenawa T	19234490	2009
26	[Triptolide evaluates DNA methylation level of matrix metalloproteinase 9 gene in human fibrosarcoma HT-1080 cells]. ⁵³ ⁶²	Yang S...Lu Q	19526795	2009
27	Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. ⁵³ ⁶²	Yodkeeree S...Limtrakul P	18495463	2009
28	Chondroitin sulfate A regulates fibrosarcoma cell adhesion, motility and migration through JNK and tyrosine kinase signaling pathways. ⁵³ ⁶²	Fthenou E...Tzanakakis GN	19368127	2009
29	Mapping proteolytic cancer cell-extracellular matrix interfaces. ⁵³ ⁶²	Wolf K...Friedl P	18600304	2009
30	TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcoma. ⁵³ ⁶²	Daigeler A...Chromik AM	19077262	2008
31	Use of the Rad51 promoter for targeted anti-cancer therapy. ⁵³ ⁶²	Hine CM...Gorbunova V	19106292	2008
32	Secretion of active membrane type 1 matrix metalloproteinase (MMP-14) into extracellular space in microvesicular exosomes. ⁵³ ⁶²	Hakulinen J...Keski-Oja J	18802920	2008
33	Transcription factors as therapeutic targets for diabetes. ⁵³ ⁶²	Miyatsuka T...Kaneto H	18851698	2008
34	Mapping local matrix remodeling induced by a migrating tumor cell using three-dimensional multiple-particle tracking. ⁵³ ⁶²	Bloom RJ...Wirtz D	18641063	2008
35	Glucose regulation of insulin gene expression in pancreatic beta-cells. ⁵³ ⁶²	Andrali SS...Ozcan S	18778246	2008
36	Flavonoid glycosides isolated from Salicornia herbacea inhibit matrix metalloproteinase in HT1080 cells. ⁵³ ⁶²	Kong CS...Seo Y	18715546	2008
37	Plasminogen activator inhibitor-2, but not cystatin C, inhibits the prometastatic activity of tissue inhibitor of metalloproteinases-1 in the liver. ⁵³ ⁶²	Kopitz C...Kruger A	18681831	2008
38	Wdnm1-like, a new adipokine with a role in MMP-2 activation. ⁵³ ⁶²	Wu Y...Smas CM	18492766	2008
39	Effects of lentivirus-mediated HIF-1alpha knockdown on hypoxia-related cisplatin resistance and their dependence on p53 status in fibrosarcoma cells. ⁵³ ⁶²	Hao J...Yu J	18421307	2008
40	Dimerization of endogenous MT1-MMP is a regulatory step in the activation of the 72-kDa gelatinase MMP-2 on fibroblasts and fibrosarcoma cells. ⁵³ ⁶²	Ingvarsen S...Engelholm LH	18627313	2008
41	Efrapeptin J, a new down-regulator of the molecular chaperone GRP78 from a marine Tolypocladium sp. ⁵³ ⁶²	Hayakawa Y...Shin-ya K	18667784	2008
42	Global and focused transcriptional profiling of small molecule aminopeptidase N inhibitor reveals its mechanism of angiogenesis inhibition. ⁵³ ⁶²	Shim JS...Kwon HJ	18413233	2008
43	Fibronectin fragmentation is a feature of periodontal disease sites and diabetic foot and leg wounds and modifies cell behavior. ⁵³ ⁶²	Stanley CM...Steffensen B	18454665	2008
44	Restoration of tumor immunosurveillance via targeting of interleukin-13 receptor-alpha 2. ⁵³ ⁶²	Fichtner-Feigl S...Strober W	18451175	2008
45	Human tissue factor pathway inhibitor-2 induces caspase-mediated apoptosis in a human fibrosarcoma cell line. ⁵³ ⁶²	Kempaiah P...Kisiel W	18401718	2008
46	Attenuation of melanoma invasion by a secreted variant of activated leukocyte cell adhesion molecule. ⁵³ ⁶²	van Kilsdonk JW...Swart GW	18483249	2008
47	A small-molecule furin inhibitor inhibits cancer cell motility and invasiveness. ⁵³ ⁶²	Coppola JM...Rehemtulla A	18392131	2008
48	Anti-cancer effect of bio-reductive drug beta-lapachon is enhanced by activating NQO1 with heat shock. ⁵³ ⁶²	Song CW...Park HJ	18283592	2008
49	Collagen-binding domains of gelatinase A and thrombospondin-derived peptides impede endocytic clearance of active gelatinase A and promote HT1080 fibrosarcoma cell invasion. ⁵³ ⁶²	Robinet A...Bellon G	18222489	2008
50	Regulation of hyaluronan and versican deposition by growth factors in fibrosarcoma cell lines. ⁵³ ⁶²	Berdiaki A...Tzanakakis GN	17980161	2008

Sources

Genes for Fibrosarcoma

Genes related to Fibrosarcoma (2 elite genes):

(show top 50) (show all 81)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	ETV6	ETS Variant Transcription Factor 6	Protein Coding	390.34	Gene fusion ⁵⁸ DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Summaries Functions (show sections)	10377438 10544023 11743047 (more) 11078523
2	NTRK3	Neurotrophic Receptor Tyrosine Kinase 3	Protein Coding	379.36	Gene fusion ⁵⁸ DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Functions (show sections)	11751416 12210087 9778053
3	MALAT1	Metastasis Associated Lung Adenocarcinoma Transcript 1	RNA Gene	150	Experimental evidence: Expression ³⁷	22491206
4	MAFA	MAF BZIP Transcription Factor A	Protein Coding	28.48	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Gene name (show sections)	19785038 18778246 17131142 (more) 17149590 18851698
5	SERPINE1	Serpin Family E Member 1	Protein Coding	26.7	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications Expressions (show sections)	9066670 2183723 8542506 (more) 12447999 12848892 16052409 2269442 10102470 1755005 1354603 2207327 2169614 1652590 15090742 9933644 16270643
6	MMP2	Matrix Metallopeptidase 2	Protein Coding	24.21	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8530350 9716492 15147870 (more) 18222489 9872597 12604329 9718371 10656606 17498959 12225805 15990687 18495463 8063786 10667602 12480918 20132738 9223434 15665286 8920947 8900440 19910495 17341207 16271263 15448610 11112341 10665843 18483249 16309669 12824510 9012863 18392131 16700822 16214327 11681709 10329442 17428670 15993560 16645235 11340084 11196190 8765191 19375915 16114507 7615567 15573686 9413149 15080939 18492766 19571375 20408816
7	MMP14	Matrix Metallopeptidase 14	Protein Coding	24.16	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10548512 9716492 15147870 (more) 18627313 11235988 16026329 10667602 11779859 11335709 12480918 17389600 16093431 11171051 10686978 8706726 19551841 17635128 16271263 12904296 11278623 16309669 15381157 9872597 17507007 16214327 12915589 20117087 19961596 18600304 14647466 9718371 18802920 17618273 15466200 11903048 9413149 11172680 16283486 18495463
8	MAF	MAF BZIP Transcription Factor	Protein Coding	23.85	DISEASES inferred ¹⁴ GeneCards inferred via : Gene name Functions (show sections)
9	MMP9	Matrix Metallopeptidase 9	Protein Coding	23.57	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15107580 11673527 10597035 (more) 17020790 9873009 9488041 17498959 1379048 19526795 1400481 12225805 15870866 11925109 17121913 9103395 7898050 19910495 17976016 16174763 16271263 16140265 15009705 12856862 9872597 9012863 8625299 17507007 16214327 15993560 16645235 16616490 8759612 19375915 10665843 7615567 17091328 16153722 15080939 18715546 18495463
10	MAFK	MAF BZIP Transcription Factor K	Protein Coding	22.86	DISEASES inferred ¹⁴ GeneCards inferred via : Gene name Functions (show sections)
11	MAFF	MAF BZIP Transcription Factor F	Protein Coding	22.51	DISEASES inferred ¹⁴ GeneCards inferred via : Gene name Functions (show sections)
12	MAFG	MAF BZIP Transcription Factor G	Protein Coding	22.41	DISEASES inferred ¹⁴ GeneCards inferred via : Gene name Functions (show sections)
13	MAFB	MAF BZIP Transcription Factor B	Protein Coding	22.21	DISEASES inferred ¹⁴ GeneCards inferred via : Publications Gene name (show sections)
14	TIMP2	TIMP Metallopeptidase Inhibitor 2	Protein Coding	21.44	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16214327 18495463 8112602 (more) 7768948 9872597 16309669 2380196 16271263 19551841
15	TNF	Tumor Necrosis Factor	Protein Coding	21.35	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8661206 2324115 8046239 (more) 8495426 2178798 2138568 2112564 9395240 17531219 1476673 10588948 10753499 8278410 8500267 1377483 1593490 2250017 2379159 11792832 11450448 11251979 1450672 1638521 1374099 16319138 7994916 8406996 8360594 1943475 2169729 1991962 2230600 2224865 2359139 7734321 7872683 8152351 2296051 18051231 7590904 7957110 8344250 8455935 1517571 1939146 2090875 14974359 10913145 18475613 16846831 15371523 12437111 10455154 8557994 8550079 8580367 9892984 9864375 9452444 8065303 8051410 8478614 8423345 2067760 17031641 16545799 10814882 9580637 9579824 7852179 8098372 8444187 15064436 11747375 11381085 10415044 9323601 8702551 7578985 8174130 10466752 9442560 2173717 10469140 8957067 8323051 8256858
16	PLAU	Plasminogen Activator, Urokinase	Protein Coding	21.21	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1901800 9164658 15033370 (more) 1652590 8542506 12447999 18495463 2159752 9654092 16822063 11805108 10402467 11984068 7672929 12848892 8495419 9202045 10807968 11004477 11592301 15962302
17	VIM	Vimentin	Protein Coding	20.49	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1710948 11014436 12354414 (more) 1376007 16322927 1752649 15471070 16053882
18	JUN	Jun Proto-Oncogene, AP-1 Transcription Factor Subunit	Protein Coding	20.39	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12753293 16950294 17020790 (more) 18451175 11514621 19405119 11861377 15130769 15358181
19	TIMP1	TIMP Metallopeptidase Inhibitor 1	Protein Coding	20.28	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16271263 17976016 16309669
20	FN1	Fibronectin 1	Protein Coding	20.18	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	17575686 7867715 12225805 (more) 17187346 1793732 18454665 19401337 8813154 18056413 19366727 2225084
21	STAT1	Signal Transducer And Activator Of Transcription 1	Protein Coding	19.83	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12589807 7539922 10201928 (more) 11971185 14500361 15826948 17523873 15649407 17283162 15883164 16914093
22	JAK1	Janus Kinase 1	Protein Coding	19.82	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9305869 9013940 12589807 (more) 7537214 9226159 9199317 9794795 16237089
23	TFPI2	Tissue Factor Pathway Inhibitor 2	Protein Coding	19.59	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	18401718 11027624 14525759 (more) 12632077 10984610
24	ACTC1	Actin Alpha Cardiac Muscle 1	Protein Coding	19.47	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8140724
25	TYK2	Tyrosine Kinase 2	Protein Coding	19.19	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9305869 7537214 9794795 (more) 9013940 9226159
26	GPI	Glucose-6-Phosphate Isomerase	Protein Coding	18.76	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	14566819
27	MMP1	Matrix Metallopeptidase 1	Protein Coding	18.62	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10092871 11861377
28	MAPK1	Mitogen-Activated Protein Kinase 1	Protein Coding	18.47	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16467968 17906919 16814409 (more) 15130769 10402467 11805108 16270297 15826948 10086335
29	JAK2	Janus Kinase 2	Protein Coding	18.25	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9305869 7537214 12063401 (more) 9794795 9013940 9226159 16081639
30	ALK	ALK Receptor Tyrosine Kinase	Protein Coding	18.23	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12594387
31	HIF1A	Hypoxia Inducible Factor 1 Subunit Alpha	Protein Coding	18.11	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19342157 16253768 18421307 (more) 17342317 17609869
32	EGR1	Early Growth Response 1	Protein Coding	18.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8876223 9714058 11121417 (more) 7585551 11925592 12210033 12553721 10380885 9933644
33	PLAUR	Plasminogen Activator, Urokinase Receptor	Protein Coding	17.93	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9135008 10807968 10537314 (more) 9654092
34	VTN	Vitronectin	Protein Coding	17.92	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	9164658 16052409 7521757 (more) 12447999
35	HMMR	Hyaluronan Mediated Motility Receptor	Protein Coding	17.57	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8750188 7541721
36	CDKN1A	Cyclin Dependent Kinase Inhibitor 1A	Protein Coding	17.53	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11691789 1844332 1844338 (more) 15899860 17486059 16739131 17585201 10815808
37	FGF2	Fibroblast Growth Factor 2	Protein Coding	17.47	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19577615 16351512 15234785 (more) 17980161 10372406 16603191
38	MMP3	Matrix Metallopeptidase 3	Protein Coding	17.4	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19212832 7629179 1379048 (more) 15358181
39	AIMP1	Aminoacyl TRNA Synthetase Complex Interacting Multifunctional Protein 1	Protein Coding	17.3	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	11527006
40	THBS1	Thrombospondin 1	Protein Coding	17.17	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1703153 14511656 12909644 (more) 16204059 18222489 12873985 9600967
41	CTSB	Cathepsin B	Protein Coding	17.05	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12185082 1522755 10866820
42	CA9	Carbonic Anhydrase 9	Protein Coding	17.02	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19342157 15752902 16270297
43	SP1	Sp1 Transcription Factor	Protein Coding	16.82	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15705902 15067326 15857802 (more) 10452548 16547158
44	CD36	CD36 Molecule	Protein Coding	16.61	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	1703153 12235000 1742797 (more) 18641063 2169765 7898050 11121411 11964074
45	PTK2	Protein Tyrosine Kinase 2	Protein Coding	16.6	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	16320111 16267014 10427099
46	MAPK8	Mitogen-Activated Protein Kinase 8	Protein Coding	16.41	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10064600 17906919 19368127
47	PDGFRA	Platelet Derived Growth Factor Receptor Alpha	Protein Coding	16.4	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	19862822
48	TGFB1	Transforming Growth Factor Beta 1	Protein Coding	16.39	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	8876223 1281156 2046332 (more) 1655396 19913614 2169772 15067357 1314170 16547158 11327694 8294500 8046239 8663000 7693717 1900875
49	MAP2K1	Mitogen-Activated Protein Kinase Kinase 1	Protein Coding	16.33	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	15147870 11805108
50	DES	Desmin	Protein Coding	16.31	Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12218574 8140724

Sources

Variations for Fibrosarcoma

Sources

Expression for Fibrosarcoma

Search GEO for disease gene expression data for Fibrosarcoma.

Sources

Pathways for Fibrosarcoma

Pathways related to Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 39)

#	Super pathways	Score	Top Affiliating Genes
1	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.27	VIM TNF TIMP1 MMP9 MMP2 JUN
2	Response to elevated platelet cytosolic Ca2+ ⁶⁶ Show member pathways Disinhibition of SNARE formation ⁶⁶ Hemostasis ⁶⁶ Platelet activation, signaling and aggregation ⁶⁶ Platelet degranulation ⁶⁶	13.24	FN1 MAFF MAFG MAFK PLAU SERPINE1
3	Extracellular matrix organization ⁶⁶ Show member pathways Degradation of the extracellular matrix ⁶⁶	12.7	FN1 MMP14 MMP2 MMP9 SERPINE1 TIMP1
4	Malignant pleural mesothelioma ⁷⁴	12.68	PLAU MMP9 MMP2 MMP14 JUN FN1
5	Colorectal Cancer Metastasis ⁶⁴	12.14	TNF MMP9 MMP2 MMP14
6	Adhesion ³	12	SERPINE1 MMP9 MMP2 MMP14
7	Spinal cord injury ⁷⁴	11.92	VIM TNF MMP9
8	TGF-beta receptor signaling in skeletal dysplasias ⁷⁴ Show member pathways TGF-beta receptor signaling ⁷⁴	11.91	TNF SERPINE1 JUN
9	Senescence and autophagy in cancer ⁷⁴	11.9	SERPINE1 PLAU MMP14 JUN FN1
10	Angiogenesis (CST) ³	11.85	MMP2 MMP9 TIMP1 TIMP2
11	Interleukin-4 and Interleukin-13 signaling ⁶⁶	11.83	VIM TNF TIMP1 MMP9 MMP2 FN1
12	CCL18 signaling pathway ⁷⁴	11.81	VIM TIMP2 TIMP1 MMP2 FN1
13	Burn wound healing ⁷⁴	11.76	TNF TIMP1 MMP9 MMP2
14	Matrix metalloproteinases ⁷⁴ Show member pathways Activation of Matrix Metalloproteinases ⁶⁶ Inhibition of Matrix Metalloproteinases ⁶⁴	11.73	TNF TIMP2 TIMP1 MMP9 MMP2 MMP14
15	Regulation of nuclear beta catenin signaling and target gene transcription ⁶¹	11.69	MMP9 MMP2 JUN
16	Photodynamic therapy-induced NF-kB survival signaling ⁷⁴ Show member pathways Immune response MIF-mediated glucocorticoid regulation ²²	11.67	TNF MMP9 MMP2 JUN
17	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ⁶¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ⁶¹	11.66	TNF MAF JUN
18	Neural crest cell migration in cancer ⁷⁴ Show member pathways Cell migration and invasion through p75NTR ⁷⁴ Neural crest cell migration during development ⁷⁴	11.65	MMP9 MMP2 JUN
19	Inflammatory bowel disease signaling ⁷⁴ Show member pathways Ulcerative colitis signaling ⁷⁴	11.59	TNF MAF JUN
20	ATF-2 transcription factor network ⁶¹	11.57	PLAU MMP2 JUN
21	Lung fibrosis ⁷⁴	11.57	TNF TIMP1 PLAU MMP9 MMP2
22	FGF signaling pathway ⁶¹	11.54	PLAU MMP9 JUN
23	LPA receptor mediated events ⁶¹	11.47	MMP9 MMP2 JUN
24	AP-1 transcription factor network ⁶¹	11.47	TIMP1 PLAU MMP9 MAFG MAF JUN
25	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling ⁶¹	11.42	SERPINE1 PLAU MMP9 FN1
26	Validated transcriptional targets of AP1 family members Fra1 and Fra2 ⁶¹	11.34	PLAU MMP9 MMP2 JUN
27	Osteopontin-mediated events ⁶¹	11.25	PLAU MMP9 MMP2 JUN
28	amb2 Integrin signaling ⁶¹	11.17	MMP2 MMP9 PLAU TNF
29	IL1 and megakaryocytes in obesity ⁷⁴	11.16	TIMP2 TIMP1 MMP9
30	Tacrolimus/Cyclosporine Pathway, Pharmacodynamics ⁶⁰	11.14	MAFK MAFG MAFF MAFB MAFA MAF
31	Cell adhesion_ECM remodeling ²²	11.01	TIMP2 TIMP1 SERPINE1 PLAU MMP9 MMP2
32	G-protein signaling_Rap2B regulation pathway ²²	10.99	VIM TNF TIMP2 TIMP1 NTRK3 JUN
33	Quercetin and Nf-kB / AP-1 induced apoptosis ⁷⁴	10.93	MAFK MAFG JUN
34	Beta5 beta6 beta7 and beta8 integrin cell surface interactions ⁶¹	10.9	PLAU FN1
35	Mammary gland development pathway - Puberty (Stage 2 of 4) ⁷⁴	10.85	FN1 TIMP1 VIM
36	TGF-beta signaling in thyroid cells for epithelial-mesenchymal transition ⁷⁴	10.82	VIM FN1
37	Osteopontin signaling ⁷⁴	10.78	PLAU MMP9
38	Dissolution of Fibrin Clot ⁶⁶	10.78	SERPINE1 PLAU
39	Ethanol metabolism production of ROS by CYP2E1 ⁷⁴	10.67	MAFK MAFG MAFF

Sources

GO Terms for Fibrosarcoma

Cellular components related to Fibrosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular matrix	GO:0031012	9.65	TIMP2 TIMP1 MMP9 MMP2 MMP14 FN1
2	serine protease inhibitor complex	GO:0097180	9.46	SERPINE1 PLAU
3	RNA polymerase II transcription regulator complex	GO:0090575	9.36	MAFK MAFG MAFF MAFB MAF JUN

Biological processes related to Fibrosarcoma according to GeneCards Suite gene sharing:

(show all 22)

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of transcription by RNA polymerase II	GO:0000122	10.34	TNF MAFK MAFG MAFF MAFB MAF
2	positive regulation of gene expression	GO:0010628	10.28	VIM TNF NTRK3 MAFG MAF FN1
3	response to hypoxia	GO:0001666	10.2	TNF PLAU MMP2 MMP14
4	regulation of DNA-templated transcription	GO:0006355	10.19	MAFK MAFG MAFF MAFB MAFA MAF
5	angiogenesis	GO:0001525	10.1	SERPINE1 MMP2 MMP14 JUN FN1
6	ephrin receptor signaling pathway	GO:0048013	10.04	NTRK3 MMP9 MMP2
7	response to mechanical stimulus	GO:0009612	10	TNF MMP2 MMP14
8	extracellular matrix disassembly	GO:0022617	9.99	MMP9 MMP2 MMP14
9	response to organic substance	GO:0010033	9.97	TNF TIMP2 TIMP1
10	response to cytokine	GO:0034097	9.96	TIMP2 TIMP1 MMP2
11	response to hormone	GO:0009725	9.95	MMP14 TIMP1 TIMP2
12	collagen catabolic process	GO:0030574	9.95	MMP14 MMP2 MMP9
13	cellular response to reactive oxygen species	GO:0034614	9.93	MMP9 MMP2 JUN
14	negative regulation of membrane protein ectodomain proteolysis	GO:0051045	9.89	TIMP2 TIMP1
15	negative regulation of plasminogen activation	GO:0010757	9.88	SERPINE1 PLAU
16	negative regulation of vascular wound healing	GO:0061044	9.83	TNF SERPINE1
17	integrated stress response signaling	GO:0140467	9.73	MAFB MAF JUN
18	regulation of epidermal cell differentiation	GO:0045604	9.67	MAFF MAFG
19	cellular response to UV-A	GO:0071492	9.63	TIMP1 MMP9 MMP2
20	negative regulation of metallopeptidase activity	GO:1905049	9.62	TIMP1 TIMP2
21	positive regulation of vascular associated smooth muscle cell proliferation	GO:1904707	9.56	TNF MMP9 MMP2 JUN
22	endodermal cell differentiation	GO:0035987	9.23	MMP9 MMP2 MMP14 FN1

Molecular functions related to Fibrosarcoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	sequence-specific double-stranded DNA binding	GO:1990837	10.03	MAFG MAFF MAFB MAFA MAF JUN
2	DNA-binding transcription activator activity, RNA polymerase II-specific	GO:0001228	10	ETV6 JUN MAF MAFA MAFB MAFF
3	DNA-binding transcription factor activity	GO:0003700	9.77	MAFK MAFG MAFF MAFB MAFA MAF
4	protease binding	GO:0002020	9.32	TNF TIMP2 TIMP1 SERPINE1 FN1