MCID: FBR002
MIFTS: 39

Fibrosarcoma of Bone

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Fibrosarcoma of Bone

MalaCards integrated aliases for Fibrosarcoma of Bone:

Name: Fibrosarcoma of Bone 12 15
Fibrosarcoma of the Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3354

Summaries for Fibrosarcoma of Bone

MalaCards based summary : Fibrosarcoma of Bone, also known as fibrosarcoma of the bone, is related to histiocytoma and inflammatory myofibroblastic tumor. An important gene associated with Fibrosarcoma of Bone is PDGFRA (Platelet Derived Growth Factor Receptor Alpha), and among its related pathways/superpathways are GPCR Pathway and Phospholipase-C Pathway. Affiliated tissues include bone, lung and liver, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Fibrosarcoma of Bone

Diseases related to Fibrosarcoma of Bone via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 histiocytoma 30.2 KIT MDM2 SERPINA3
2 inflammatory myofibroblastic tumor 29.8 CDK4 KIT MDM2
3 malignant fibroxanthoma 29.7 CDK4 MDM2 SERPINA1 SERPINA3
4 malignant fibrous histiocytoma of bone 29.3 CDK4 MDM2 MYC PTER
5 fibrosarcoma 10.6
6 primary hypereosinophilic syndrome 10.3 PDGFRA PDGFRB
7 reticular perineurioma 10.3 KIT PDGFRA
8 sm-ahnmd 10.3 KIT PDGFRA
9 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.3 PDGFRA PDGFRB
10 adenosquamous gallbladder carcinoma 10.3 PDGFRA SERPINA3
11 gastric leiomyosarcoma 10.2 KIT PDGFRA
12 pulmonary vein stenosis 10.2 KDR KIT PDGFRA
13 desmoid tumor 10.2 KIT PDGFRA PDGFRB
14 cervical adenosquamous carcinoma 10.2 CDKN2A KDR PDGFRA
15 hepatic angiomyolipoma 10.2 KIT MYC
16 hypereosinophilic syndrome 10.2 KIT PDGFRA PDGFRB
17 hypereosinophilic syndrome, idiopathic 10.2 KIT PDGFRA PDGFRB
18 endometrial small cell carcinoma 10.2 KIT PDGFRA
19 cavernous hemangioma 10.2 KDR KIT PDGFRA
20 chronic eosinophilic leukemia 10.2 KIT PDGFRA PDGFRB
21 spinal chordoma 10.2 KDR PDGFRA PDGFRB
22 adenoid basal cell carcinoma 10.2 CDKN2A KIT
23 neurofibroma 10.2 CDKN2A KIT PDGFRA
24 chordoma 10.2 CDKN2A PDGFRA PDGFRB
25 8p11 myeloproliferative syndrome 10.2 KDR KIT PDGFRB
26 tenosynovial giant cell tumor 10.2 CDKN2A SERPINA3
27 systemic mastocytosis 10.2 KIT PDGFRA PDGFRB
28 small cell carcinoma 10.2 CDKN2A KIT PDGFRA
29 mastocytosis 10.2 KIT PDGFRA PDGFRB
30 vascular cancer 10.2 KDR KIT PDGFRB
31 malignant epithelioid hemangioendothelioma 10.2 KDR MYC
32 myeloproliferative neoplasm 10.2 KIT PDGFRA PDGFRB
33 esophagus sarcoma 10.2 CREB3L2 KIT
34 bone squamous cell carcinoma 10.2 CDKN2A KDR
35 acinar cell cystadenocarcinoma 10.2 SERPINA1 SERPINA3
36 angiosarcoma 10.2 KDR KIT MYC
37 pleomorphic liposarcoma 10.1 CDKN2A MDM2 PDGFRA
38 pharynx cancer 10.1 CDKN2A KIT MYC
39 polycythemia vera 10.1 KIT PDGFRA PDGFRB
40 uterine sarcoma 10.1 KIT MDM2 PDGFRB
41 endocrine gland cancer 10.1 CDKN2A KDR MYC
42 scrotal carcinoma 10.1 CDKN2A SERPINA3
43 bone marrow cancer 10.1 KDR KIT PDGFRA PDGFRB
44 salivary gland carcinoma 10.1 CDKN2A KIT MDM2
45 cutaneous solitary mastocytoma 10.1 KIT SERPINA1 SERPINA3
46 acral lentiginous melanoma 10.1 CDKN2A KIT
47 dermatofibrosarcoma protuberans 10.1 KIT PDGFRA PDGFRB SERPINA3
48 ring chromosome 7 10.1 CDK4 MDM2
49 gastrointestinal stromal tumor 10.1 CDKN2A KIT PDGFRA PDGFRB
50 cornea cancer 10.1 CDK4 CDKN2A

Graphical network of the top 20 diseases related to Fibrosarcoma of Bone:



Diseases related to Fibrosarcoma of Bone

Symptoms & Phenotypes for Fibrosarcoma of Bone

GenomeRNAi Phenotypes related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.99 PDGFRA
2 Decreased viability GR00221-A-1 9.99 CDKN2A KDR MYC PDGFRA PDGFRB KIT
3 Decreased viability GR00221-A-2 9.99 KDR
4 Decreased viability GR00221-A-3 9.99 CDKN2A KDR MYC PDGFRA PDGFRB
5 Decreased viability GR00221-A-4 9.99 CDKN2A KDR PDGFRA PDGFRB
6 Decreased viability GR00301-A 9.99 KIT
7 Decreased viability GR00342-S-1 9.99 PDGFRB
8 Decreased viability GR00402-S-2 9.99 CDKN2A KDR MYC PDGFRA PDGFRB KIT
9 Decreased substrate adherent cell growth GR00193-A-1 9.5 KIT
10 Decreased substrate adherent cell growth GR00193-A-2 9.5 CDK4 KIT
11 Decreased substrate adherent cell growth GR00193-A-3 9.5 CDK4
12 Decreased substrate adherent cell growth GR00193-A-4 9.5 CDK4 KDR KIT

MGI Mouse Phenotypes related to Fibrosarcoma of Bone:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.35 CDK4 CDKN2A ING1 KDR KIT MDM2
2 growth/size/body region MP:0005378 10.29 CDK4 CDKN2A CREB3L2 ING1 KDR KIT
3 behavior/neurological MP:0005386 10.28 CDK4 CDKN2A ING1 KDR KIT MDM2
4 hematopoietic system MP:0005397 10.27 CDK4 CDKN2A ING1 KDR KIT MDM2
5 cardiovascular system MP:0005385 10.23 CDK4 CDKN2A KDR KIT MDM2 MYC
6 immune system MP:0005387 10.23 CDK4 CDKN2A ING1 KDR KIT MDM2
7 endocrine/exocrine gland MP:0005379 10.22 CDK4 CDKN2A ING1 KIT MDM2 MYC
8 homeostasis/metabolism MP:0005376 10.22 CDK4 CDKN2A ING1 KDR KIT MDM2
9 embryo MP:0005380 10.19 CDK4 CDKN2A KDR KIT MDM2 MYC
10 craniofacial MP:0005382 10.16 CREB3L2 KDR KIT MDM2 MYC NFATC2
11 digestive/alimentary MP:0005381 10.15 CDK4 CDKN2A CREB3L2 KIT MDM2 MYC
12 mortality/aging MP:0010768 10.15 CDK4 CDKN2A CREB3L2 ING1 KDR KIT
13 integument MP:0010771 10.03 CDK4 CDKN2A KDR KIT MDM2 MYC
14 muscle MP:0005369 9.97 CDK4 CDKN2A KDR KIT MDM2 MYC
15 neoplasm MP:0002006 9.91 CDK4 CDKN2A ING1 KIT MDM2 MYC
16 limbs/digits/tail MP:0005371 9.88 CREB3L2 KIT MDM2 MYC PDGFRA PDGFRB
17 no phenotypic analysis MP:0003012 9.7 CDKN2A KDR KIT MDM2 MYC PDGFRA
18 pigmentation MP:0001186 9.43 CDK4 CDKN2A KIT MDM2 MYC PDGFRA
19 skeleton MP:0005390 9.28 CDKN2A CREB3L2 KDR KIT MDM2 MYC

Drugs & Therapeutics for Fibrosarcoma of Bone

Search Clinical Trials , NIH Clinical Center for Fibrosarcoma of Bone

Genetic Tests for Fibrosarcoma of Bone

Anatomical Context for Fibrosarcoma of Bone

MalaCards organs/tissues related to Fibrosarcoma of Bone:

41
Bone, Lung, Liver, Heart, Salivary Gland, Myeloid, Bone Marrow

Publications for Fibrosarcoma of Bone

Articles related to Fibrosarcoma of Bone:

(show all 30)
# Title Authors Year
1
Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone. ( 29908016 )
2018
2
Primary sclerosing epithelioid fibrosarcoma of bone: analysis of a series. ( 24921641 )
2014
3
Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches. ( 23001328 )
2012
4
Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone--an array comparative genomic hybridization study. ( 19862822 )
2010
5
Tiling resolution array comparative genomic hybridization analysis of a fibrosarcoma of bone. ( 17175386 )
2007
6
Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone. ( 15540465 )
2004
7
Metastatic secondary fibrosarcoma of bone responsive to repeated courses of Ifosfamide and associated with hypoglycemia. ( 18521374 )
2003
8
Clinicopathologic features, diagnosis, and treatment of fibrosarcoma of bone. ( 12041516 )
2002
9
Primary fibrosarcoma of bone. Outcome after primary surgical treatment. ( 10810466 )
2000
10
Multiple diffuse fibrosarcoma of bone. ( 10614764 )
1999
11
Multiple diffuse fibrosarcoma of bone associated with extramedullary hematopoiesis. ( 9652906 )
1998
12
Multiple diffuse fibrosarcoma of bone. ( 3843661 )
1985
13
Primary central (medullary) fibrosarcoma of bone. ( 6599928 )
1984
14
Definitions of osteosarcoma, chondrosarcoma, and fibrosarcoma of bone. ( 6930319 )
1980
15
Central fibrosarcoma of bone. Report of a case. ( 452904 )
1979
16
Fibrosarcoma of bone. A study of 114 cases. ( 612638 )
1977
17
Fibrosarcoma of bone and soft tissues of the trunk and extremities. ( 917469 )
1977
18
Fibrosarcoma of bone. A demographic, clinical and histopathological study of all cases recorded in the Swedish cancer registry from 1958 to 1968. ( 1071089 )
1976
19
Multiple diffuse fibrosarcoma of bone. ( 1253118 )
1976
20
Metastatic spread of fibrosarcoma of bone; A report on forty-nine cases, and a comparison with osteosarcoma. ( 1071090 )
1976
21
A spectacular fibrosarcoma of bone. ( 1269140 )
1976
22
Primary fibrosarcoma of bone. A clinicopathologic study of 130 patients. ( 1053940 )
1975
23
Fibrosarcoma of bone. Review of fifty consecutive cases from the Bristol Bone Tumour Registry. ( 5766357 )
1969
24
Fibrosarcoma of bone. A study of 114 cases. ( 5249422 )
1969
25
Medullary fibrosarcoma of bone. ( 5235191 )
1968
26
Primary medullary fibrosarcoma of bone: a case report. ( 13940805 )
1962
27
A bone tumour registry--chondrosarcoma and fibrosarcoma of bone. ( 13697723 )
1961
28
Central (medullary) fibrosarcoma of bone. ( 13491615 )
1958
29
Fibrosarcoma of bone. ( 13458607 )
1957
30
Multiple Diffuse Fibrosarcoma of Bone. ( 19970785 )
1944

Variations for Fibrosarcoma of Bone

Expression for Fibrosarcoma of Bone

Search GEO for disease gene expression data for Fibrosarcoma of Bone.

Pathways for Fibrosarcoma of Bone

Pathways related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

(show all 39)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.64 CDK4 CDKN2A KDR KIT MDM2 MYC
2
Show member pathways
13 KDR KIT MDM2 NFATC2 PDGFRA PDGFRB
3
Show member pathways
12.95 CDK4 CDKN2A CREB3L2 MDM2 MYC NFATC2
4
Show member pathways
12.76 CDK4 CREB3L2 KDR KIT MDM2 MYC
5 12.7 KDR KIT MYC PDGFRA PDGFRB
6 12.7 CDK4 CDKN2A KIT MDM2 MYC PDGFRA
7
Show member pathways
12.68 CDK4 CDKN2A KDR MDM2 PDGFRA PDGFRB
8
Show member pathways
12.6 CDK4 CDKN2A CREB3L2 KIT MDM2 MYC
9
Show member pathways
12.5 CDK4 CDKN2A MDM2 MYC
10 12.44 CDKN2A MDM2 MYC PDGFRA PDGFRB
11
Show member pathways
12.38 KDR MDM2 PDGFRA PDGFRB
12
Show member pathways
12.36 CDK4 CDKN2A CREB3L2 KIT
13
Show member pathways
12.32 CDK4 CDKN2A MDM2 MYC
14 12.3 CDK4 CDKN2A MDM2 MYC
15 12.25 CDK4 CDKN2A MYC NFATC2 PDGFRA PDGFRB
16 12.24 CDK4 CDKN2A CREB3L2 MDM2
17
Show member pathways
12.2 KDR KIT MYC PDGFRA PDGFRB
18 12.07 KDR KIT PDGFRA PDGFRB
19 12.06 CDK4 CDKN2A MDM2 MYC NFATC2
20 12.01 KDR MYC PDGFRB SERPINA1
21 11.92 CDKN2A MDM2 MYC
22
Show member pathways
11.88 CDK4 CREB3L2 KDR MDM2 MYC PDGFRA
23 11.87 CDKN2A ING1 MDM2
24 11.79 KDR PDGFRA PDGFRB
25 11.78 CDK4 MDM2 MYC
26
Show member pathways
11.75 KDR KIT PDGFRB
27
Show member pathways
11.7 KDR KIT PDGFRA PDGFRB
28 11.66 CDK4 CDKN2A MDM2 MYC
29 11.59 KIT MYC PDGFRA PDGFRB
30 11.52 KDR KIT PDGFRA
31 11.48 CDK4 CDKN2A MDM2 MYC PDGFRA PDGFRB
32 11.45 CDK4 MDM2 MYC
33 11.42 CDK4 MDM2 MYC
34 11.33 KDR MYC PDGFRA PDGFRB
35 11.32 CDK4 CREB3L2 KDR MDM2 MYC PDGFRA
36 11.26 CDK4 CDKN2A MDM2
37 11.08 CDKN2A MDM2 MYC
38
Show member pathways
11.07 CDKN2A MDM2 MYC
39 10.82 PDGFRA PDGFRB

GO Terms for Fibrosarcoma of Bone

Cellular components related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.77 CDK4 CDKN2A CHD1L CREB3L2 ING1 KDR
2 receptor complex GO:0043235 8.92 KDR KIT PDGFRA PDGFRB

Biological processes related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.95 CDK4 MDM2 MYC NFATC2
2 negative regulation of apoptotic process GO:0043066 9.93 KDR KIT MDM2 MYC PDGFRA PDGFRB
3 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.91 KDR KIT PDGFRA PDGFRB
4 positive regulation of cell migration GO:0030335 9.89 KDR KIT PDGFRA PDGFRB
5 MAPK cascade GO:0000165 9.88 KIT MYC PDGFRA PDGFRB
6 phosphatidylinositol phosphorylation GO:0046854 9.84 KIT PDGFRA PDGFRB
7 peptidyl-tyrosine phosphorylation GO:0018108 9.84 KDR KIT PDGFRA PDGFRB
8 protein autophosphorylation GO:0046777 9.83 KDR KIT PDGFRA PDGFRB
9 response to toxic substance GO:0009636 9.8 CDK4 MDM2 PDGFRB
10 G1/S transition of mitotic cell cycle GO:0000082 9.8 CDK4 CDKN2A MYC
11 positive regulation of gene expression GO:0010628 9.8 CDKN2A CREB3L2 KIT MDM2 MYC NFATC2
12 cell chemotaxis GO:0060326 9.79 KIT PDGFRA PDGFRB
13 positive regulation of MAPK cascade GO:0043410 9.78 KDR KIT PDGFRA PDGFRB
14 positive regulation of cell cycle GO:0045787 9.72 CDK4 MDM2 MYC
15 negative regulation of signal transduction GO:0009968 9.71 KDR KIT PDGFRA PDGFRB
16 cardiac myofibril assembly GO:0055003 9.67 PDGFRA PDGFRB
17 positive regulation of smooth muscle cell migration GO:0014911 9.67 MYC PDGFRB
18 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.67 KDR KIT PDGFRA PDGFRB
19 embryonic hemopoiesis GO:0035162 9.66 KDR KIT
20 cellular response to estrogen stimulus GO:0071391 9.65 MDM2 MYC
21 positive regulation of DNA biosynthetic process GO:2000573 9.64 MYC PDGFRB
22 response to hyperoxia GO:0055093 9.63 CDK4 PDGFRB
23 somatic stem cell division GO:0048103 9.61 CDKN2A KIT
24 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.61 KIT PDGFRA PDGFRB
25 amyloid fibril formation GO:1990000 9.6 CDKN2A MDM2
26 retina vasculature development in camera-type eye GO:0061298 9.58 PDGFRA PDGFRB
27 obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.57 CDK4 CDKN2A
28 cellular response to phorbol 13-acetate 12-myristate GO:1904628 9.56 CDK4 MYC
29 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.56 KDR KIT PDGFRA PDGFRB
30 metanephric glomerular capillary formation GO:0072277 9.51 PDGFRA PDGFRB
31 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.49 PDGFRA PDGFRB
32 positive regulation of phospholipase C activity GO:0010863 9.33 KIT PDGFRA PDGFRB
33 positive regulation of fibroblast proliferation GO:0048146 9.26 CDK4 MYC PDGFRA PDGFRB
34 positive regulation of cell proliferation GO:0008284 9.17 CDK4 KDR KIT MDM2 MYC PDGFRA
35 phosphorylation GO:0016310 10.06 CDK4 KDR KIT PDGFRA PDGFRB
36 protein phosphorylation GO:0006468 10.05 CDK4 KDR KIT PDGFRA PDGFRB
37 positive regulation of transcription, DNA-templated GO:0045893 10.04 CDKN2A CREB3L2 ING1 MYC NFATC2

Molecular functions related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 kinase activity GO:0016301 9.92 CDK4 KDR KIT PDGFRA PDGFRB
2 protein kinase activity GO:0004672 9.85 CDK4 KDR KIT PDGFRA PDGFRB
3 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.69 KIT PDGFRA PDGFRB
4 transmembrane signaling receptor activity GO:0004888 9.67 KDR KIT PDGFRA PDGFRB
5 nucleotide binding GO:0000166 9.65 CDK4 CHD1L KIT PDGFRA PDGFRB
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.58 KIT PDGFRA PDGFRB
7 platelet-derived growth factor receptor binding GO:0005161 9.49 PDGFRA PDGFRB
8 platelet-derived growth factor binding GO:0048407 9.48 PDGFRA PDGFRB
9 protein tyrosine kinase activity GO:0004713 9.46 KDR KIT PDGFRA PDGFRB
10 vascular endothelial growth factor-activated receptor activity GO:0005021 9.32 KDR PDGFRA
11 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.26 KDR KIT PDGFRA PDGFRB
12 vascular endothelial growth factor binding GO:0038085 8.8 KDR PDGFRA PDGFRB
13 protein binding GO:0005515 10.31 CDK4 CDKN2A CHD1L ING1 KDR KIT

Sources for Fibrosarcoma of Bone

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....