MCID: FBR002
MIFTS: 36

Fibrosarcoma of Bone

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Fibrosarcoma of Bone

MalaCards integrated aliases for Fibrosarcoma of Bone:

Name: Fibrosarcoma of Bone 12 15
Fibrosarcoma of the Bone 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3354

Summaries for Fibrosarcoma of Bone

MalaCards based summary : Fibrosarcoma of Bone, also known as fibrosarcoma of the bone, is related to histiocytoma and malignant fibroxanthoma. An important gene associated with Fibrosarcoma of Bone is PDGFRA (Platelet Derived Growth Factor Receptor Alpha), and among its related pathways/superpathways are GPCR Pathway and Phospholipase-C Pathway. Affiliated tissues include bone, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Fibrosarcoma of Bone

Diseases related to Fibrosarcoma of Bone via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Related Disease Score Top Affiliating Genes
1 histiocytoma 29.9 CDK4 KIT MDM2 SERPINA3
2 malignant fibroxanthoma 29.6 CDK4 MDM2 SERPINA1 SERPINA3
3 malignant fibrous histiocytoma of bone 28.0 CALD1 CDK4 MDM2 MYC PTER
4 reticular perineurioma 10.9 KIT PDGFRA
5 primary hypereosinophilic syndrome 10.9 PDGFRA PDGFRB
6 myeloid and lymphoid neoplasms with eosinophilia and abnormalities of pdgfra, pdgfrb, and fgfr1 10.9 PDGFRA PDGFRB
7 adenosquamous gallbladder carcinoma 10.8 PDGFRA SERPINA3
8 sm-ahnmd 10.8 KIT PDGFRA
9 pulmonary vein stenosis 10.8 KDR KIT PDGFRA
10 cervical adenosquamous carcinoma 10.7 CDKN2A KDR PDGFRA
11 desmoid tumor 10.7 KIT PDGFRA PDGFRB
12 hypereosinophilic syndrome, idiopathic 10.7 KIT PDGFRA PDGFRB
13 hepatic angiomyolipoma 10.7 KIT MYC
14 gastric leiomyosarcoma 10.7 KIT PDGFRA
15 chronic eosinophilic leukemia 10.7 KIT PDGFRA PDGFRB
16 spinal chordoma 10.7 KDR PDGFRA PDGFRB
17 8p11 myeloproliferative syndrome 10.7 KDR KIT PDGFRB
18 neurofibroma 10.7 CDKN2A KIT PDGFRA
19 systemic mastocytosis 10.7 KIT PDGFRA PDGFRB
20 vascular cancer 10.7 KDR KIT PDGFRB
21 mast cell disease 10.7 KIT PDGFRA PDGFRB
22 leukocyte disease 10.7 KIT PDGFRA PDGFRB
23 myeloproliferative neoplasm 10.6 KIT PDGFRA PDGFRB
24 adenoid basal cell carcinoma 10.6 CDKN2A KIT
25 acinar cell cystadenocarcinoma 10.6 SERPINA1 SERPINA3
26 ring chromosome 7 10.6 CDK4 MDM2
27 tenosynovial giant cell tumor 10.6 CDKN2A SERPINA3
28 hypereosinophilic syndrome 10.6 KIT PDGFRA PDGFRB
29 angiosarcoma 10.6 KDR KIT MYC
30 deep leiomyoma 10.5 CALD1 KIT
31 uterine sarcoma 10.5 KIT MDM2 PDGFRB
32 ewing's family of tumors 10.5 CDK4 CDKN2A KIT
33 spindle cell lipoma 10.5 CDK4 MDM2
34 cutaneous solitary mastocytoma 10.5 KIT SERPINA1 SERPINA3
35 dermatofibrosarcoma protuberans 10.4 KIT PDGFRA PDGFRB SERPINA3
36 bone marrow cancer 10.4 KDR KIT PDGFRA PDGFRB
37 fibrosarcoma 10.4
38 extraosseous osteosarcoma 10.4 CDK4 MDM2
39 gastrointestinal stromal tumor 10.4 CDKN2A KIT PDGFRA PDGFRB
40 infiltrating angiolipoma 10.4 CDK4 CDKN2A MDM2
41 ovarian melanoma 10.4 CALD1 KIT
42 bone osteosarcoma 10.4 CDK4 MDM2
43 ischemic fasciitis 10.4 CDK4 CDKN2A MDM2
44 gastrointestinal system cancer 10.4 CDKN2A KIT MYC PDGFRA
45 periosteal chondrosarcoma 10.4 CDK4 CDKN2A MDM2
46 undifferentiated embryonal sarcoma of the liver 10.4 CDK4 MDM2 SERPINA3
47 well-differentiated liposarcoma 10.4 CDK4 CDKN2A MDM2
48 dedifferentiated liposarcoma 10.4 CDK4 CDKN2A MDM2
49 nodular tenosynovitis 10.4 PTER SERPINA3
50 sarcomatoid renal cell carcinoma 10.3 KIT PDGFRA

Graphical network of the top 20 diseases related to Fibrosarcoma of Bone:



Diseases related to Fibrosarcoma of Bone

Symptoms & Phenotypes for Fibrosarcoma of Bone

GenomeRNAi Phenotypes related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00173-A 9.99 PDGFRA
2 Decreased viability GR00221-A-1 9.99 MYC CDKN2A PDGFRA KDR PDGFRB KIT
3 Decreased viability GR00221-A-2 9.99 KDR
4 Decreased viability GR00221-A-3 9.99 MYC CDKN2A PDGFRA KDR PDGFRB
5 Decreased viability GR00221-A-4 9.99 CDKN2A PDGFRA KDR PDGFRB
6 Decreased viability GR00301-A 9.99 KIT
7 Decreased viability GR00342-S-1 9.99 PDGFRB
8 Decreased viability GR00402-S-2 9.99 MYC CDKN2A PDGFRA KDR PDGFRB KIT
9 Decreased substrate adherent cell growth GR00193-A-1 9.5 KIT
10 Decreased substrate adherent cell growth GR00193-A-2 9.5 CDK4 KIT
11 Decreased substrate adherent cell growth GR00193-A-3 9.5 CDK4
12 Decreased substrate adherent cell growth GR00193-A-4 9.5 KIT CDK4 KDR

MGI Mouse Phenotypes related to Fibrosarcoma of Bone:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.28 ING1 CDK4 KDR CDKN2A KIT MYC
2 behavior/neurological MP:0005386 10.26 ING1 CDK4 KDR CDKN2A KIT MYC
3 growth/size/body region MP:0005378 10.23 CREB3L2 ING1 CDK4 KDR CDKN2A KIT
4 cardiovascular system MP:0005385 10.2 CDK4 KDR CDKN2A KIT MYC MDM2
5 endocrine/exocrine gland MP:0005379 10.18 CDK4 ING1 CDKN2A KIT MYC MDM2
6 hematopoietic system MP:0005397 10.17 ING1 CDK4 KDR CDKN2A KIT MYC
7 embryo MP:0005380 10.15 CDK4 KDR CDKN2A KIT MYC MDM2
8 immune system MP:0005387 10.14 ING1 CDK4 KDR CDKN2A KIT MYC
9 craniofacial MP:0005382 10.13 CREB3L2 KDR KIT MYC MDM2 NFATC2
10 digestive/alimentary MP:0005381 10.11 CREB3L2 CDK4 CDKN2A KIT MYC MDM2
11 integument MP:0010771 9.97 CDK4 KDR CDKN2A KIT MYC MDM2
12 muscle MP:0005369 9.91 CDK4 KDR CDKN2A KIT MDM2 NFATC2
13 limbs/digits/tail MP:0005371 9.8 CREB3L2 KIT MYC MDM2 PDGFRA PDGFRB
14 neoplasm MP:0002006 9.76 CDK4 ING1 CDKN2A KIT MDM2 PDGFRA
15 pigmentation MP:0001186 9.43 CDK4 CDKN2A KIT MYC MDM2 PDGFRA
16 skeleton MP:0005390 9.28 CREB3L2 KDR CDKN2A KIT MYC MDM2

Drugs & Therapeutics for Fibrosarcoma of Bone

Search Clinical Trials , NIH Clinical Center for Fibrosarcoma of Bone

Genetic Tests for Fibrosarcoma of Bone

Anatomical Context for Fibrosarcoma of Bone

MalaCards organs/tissues related to Fibrosarcoma of Bone:

41
Bone

Publications for Fibrosarcoma of Bone

Articles related to Fibrosarcoma of Bone:

(show all 30)
# Title Authors Year
1
Peroxiredoxin 1 (PRDX1) Suppresses Progressions and Metastasis of Osteosarcoma and Fibrosarcoma of Bone. ( 29908016 )
2018
2
Primary sclerosing epithelioid fibrosarcoma of bone: analysis of a series. ( 24921641 )
2014
3
Malignant fibrous histiocytoma and fibrosarcoma of bone: a re-assessment in the light of currently employed morphological, immunohistochemical and molecular approaches. ( 23001328 )
2012
4
Frequent deletion of CDKN2A and recurrent coamplification of KIT, PDGFRA, and KDR in fibrosarcoma of bone--an array comparative genomic hybridization study. ( 19862822 )
2010
5
Tiling resolution array comparative genomic hybridization analysis of a fibrosarcoma of bone. ( 17175386 )
2007
6
Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone. ( 15540465 )
2004
7
Metastatic secondary fibrosarcoma of bone responsive to repeated courses of Ifosfamide and associated with hypoglycemia. ( 18521374 )
2003
8
Clinicopathologic features, diagnosis, and treatment of fibrosarcoma of bone. ( 12041516 )
2002
9
Primary fibrosarcoma of bone. Outcome after primary surgical treatment. ( 10810466 )
2000
10
Multiple diffuse fibrosarcoma of bone. ( 10614764 )
1999
11
Multiple diffuse fibrosarcoma of bone associated with extramedullary hematopoiesis. ( 9652906 )
1998
12
Multiple diffuse fibrosarcoma of bone. ( 3843661 )
1985
13
Primary central (medullary) fibrosarcoma of bone. ( 6599928 )
1984
14
Definitions of osteosarcoma, chondrosarcoma, and fibrosarcoma of bone. ( 6930319 )
1980
15
Central fibrosarcoma of bone. Report of a case. ( 452904 )
1979
16
Fibrosarcoma of bone. A study of 114 cases. ( 612638 )
1977
17
Fibrosarcoma of bone and soft tissues of the trunk and extremities. ( 917469 )
1977
18
Fibrosarcoma of bone. A demographic, clinical and histopathological study of all cases recorded in the Swedish cancer registry from 1958 to 1968. ( 1071089 )
1976
19
Multiple diffuse fibrosarcoma of bone. ( 1253118 )
1976
20
Metastatic spread of fibrosarcoma of bone; A report on forty-nine cases, and a comparison with osteosarcoma. ( 1071090 )
1976
21
A spectacular fibrosarcoma of bone. ( 1269140 )
1976
22
Primary fibrosarcoma of bone. A clinicopathologic study of 130 patients. ( 1053940 )
1975
23
Fibrosarcoma of bone. Review of fifty consecutive cases from the Bristol Bone Tumour Registry. ( 5766357 )
1969
24
Fibrosarcoma of bone. A study of 114 cases. ( 5249422 )
1969
25
Medullary fibrosarcoma of bone. ( 5235191 )
1968
26
Primary medullary fibrosarcoma of bone: a case report. ( 13940805 )
1962
27
A bone tumour registry--chondrosarcoma and fibrosarcoma of bone. ( 13697723 )
1961
28
Central (medullary) fibrosarcoma of bone. ( 13491615 )
1958
29
Fibrosarcoma of bone. ( 13458607 )
1957
30
Multiple Diffuse Fibrosarcoma of Bone. ( 19970785 )
1944

Variations for Fibrosarcoma of Bone

Expression for Fibrosarcoma of Bone

Search GEO for disease gene expression data for Fibrosarcoma of Bone.

Pathways for Fibrosarcoma of Bone

Pathways related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

(show all 37)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.65 CDK4 CDKN2A KDR KIT MDM2 MYC
2
Show member pathways
12.98 KDR KIT MDM2 NFATC2 PDGFRA PDGFRB
3
Show member pathways
12.75 CDK4 CREB3L2 KDR KIT MDM2 MYC
4 12.7 CDK4 CDKN2A KIT MDM2 MYC PDGFRA
5 12.69 KDR KIT MYC PDGFRA PDGFRB
6
Show member pathways
12.69 CDK4 CDKN2A KDR MDM2 PDGFRA PDGFRB
7
Show member pathways
12.5 CDK4 CDKN2A CREB3L2 KIT MDM2 MYC
8
Show member pathways
12.49 CDK4 CREB3L2 MYC NFATC2
9
Show member pathways
12.49 CDK4 CDKN2A MDM2 MYC
10 12.44 CDKN2A MDM2 MYC PDGFRA PDGFRB
11
Show member pathways
12.37 KDR MDM2 PDGFRA PDGFRB
12
Show member pathways
12.31 CDK4 CDKN2A MDM2 MYC
13 12.29 CDK4 CDKN2A MDM2 MYC
14 12.25 CDK4 CDKN2A MYC NFATC2 PDGFRA PDGFRB
15 12.22 CDK4 CDKN2A CREB3L2 MDM2
16 12.06 KDR KIT PDGFRA PDGFRB
17 12.06 CDK4 CDKN2A MDM2 MYC NFATC2
18 12 KDR MYC PDGFRB SERPINA1
19 11.9 CDKN2A MDM2 MYC
20 11.86 CDKN2A ING1 MDM2
21
Show member pathways
11.84 CDK4 KDR MYC PDGFRA PDGFRB
22 11.78 KDR PDGFRA PDGFRB
23 11.77 CDK4 MDM2 MYC
24
Show member pathways
11.74 KDR KIT PDGFRB
25 11.67 CDK4 CDKN2A MDM2 MYC
26 11.61 KIT MYC PDGFRA PDGFRB
27
Show member pathways
11.57 KDR KIT PDGFRA PDGFRB
28 11.51 KDR KIT PDGFRA
29 11.48 CDK4 CDKN2A MDM2 MYC PDGFRA PDGFRB
30 11.44 CDK4 MDM2 MYC
31 11.41 CDK4 MDM2 MYC
32 11.33 KDR MYC PDGFRA PDGFRB
33 11.32 CDK4 CREB3L2 KDR MDM2 MYC PDGFRA
34 11.24 CDK4 CDKN2A MDM2
35 11.05 CDKN2A MDM2 MYC
36
Show member pathways
11.04 CDKN2A MDM2 MYC
37 10.8 PDGFRA PDGFRB

GO Terms for Fibrosarcoma of Bone

Cellular components related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 8.92 KDR KIT PDGFRA PDGFRB

Biological processes related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.97 CDK4 MDM2 MYC NFATC2
2 positive regulation of gene expression GO:0010628 9.97 CDKN2A KIT MDM2 MYC NFATC2
3 MAPK cascade GO:0000165 9.94 KIT MYC PDGFRA PDGFRB
4 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.92 KDR KIT PDGFRA PDGFRB
5 negative regulation of apoptotic process GO:0043066 9.91 KDR KIT MDM2 MYC PDGFRA PDGFRB
6 positive regulation of cell migration GO:0030335 9.88 KDR KIT PDGFRA PDGFRB
7 protein autophosphorylation GO:0046777 9.87 KDR KIT PDGFRA PDGFRB
8 response to toxic substance GO:0009636 9.84 CDK4 MDM2 PDGFRB
9 peptidyl-tyrosine phosphorylation GO:0018108 9.84 KDR KIT PDGFRA PDGFRB
10 G1/S transition of mitotic cell cycle GO:0000082 9.83 CDK4 CDKN2A MYC
11 phosphatidylinositol phosphorylation GO:0046854 9.83 KIT PDGFRA PDGFRB
12 positive regulation of MAPK cascade GO:0043410 9.83 KDR KIT PDGFRA PDGFRB
13 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.8 KDR KIT PDGFRA PDGFRB
14 cell chemotaxis GO:0060326 9.79 KIT PDGFRA PDGFRB
15 negative regulation of signal transduction GO:0009968 9.71 KDR KIT PDGFRA PDGFRB
16 positive regulation of cell cycle GO:0045787 9.69 CDK4 MDM2 MYC
17 cardiac myofibril assembly GO:0055003 9.68 PDGFRA PDGFRB
18 embryonic hemopoiesis GO:0035162 9.67 KDR KIT
19 cellular response to estrogen stimulus GO:0071391 9.65 MDM2 MYC
20 response to hyperoxia GO:0055093 9.65 CDK4 PDGFRB
21 positive regulation of DNA biosynthetic process GO:2000573 9.64 MYC PDGFRB
22 maintenance of gastrointestinal epithelium GO:0030277 9.63 MUC4 SERPINA3
23 somatic stem cell division GO:0048103 9.63 CDKN2A KIT
24 positive regulation of kinase activity GO:0033674 9.62 KDR KIT PDGFRA PDGFRB
25 amyloid fibril formation GO:1990000 9.61 CDKN2A MDM2
26 negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587 9.61 PDGFRA PDGFRB
27 negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031658 9.6 CDK4 CDKN2A
28 retina vasculature development in camera-type eye GO:0061298 9.59 PDGFRA PDGFRB
29 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.56 KDR KIT PDGFRA PDGFRB
30 cellular response to phorbol 13-acetate 12-myristate GO:1904628 9.55 CDK4 MYC
31 positive regulation of phosphatidylinositol 3-kinase activity GO:0043552 9.54 KIT PDGFRA PDGFRB
32 positive regulation of cell proliferation GO:0008284 9.5 CDK4 KDR KIT MDM2 MYC PDGFRA
33 positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway GO:0038091 9.48 PDGFRA PDGFRB
34 metanephric glomerular capillary formation GO:0072277 9.46 PDGFRA PDGFRB
35 positive regulation of fibroblast proliferation GO:0048146 9.46 CDK4 MYC PDGFRA PDGFRB
36 positive regulation of phospholipase C activity GO:0010863 8.8 KIT PDGFRA PDGFRB
37 protein phosphorylation GO:0006468 10.07 CDK4 KDR KIT PDGFRA PDGFRB
38 positive regulation of transcription, DNA-templated GO:0045893 10.06 CDKN2A CREB3L2 ING1 MYC NFATC2
39 phosphorylation GO:0016310 10.03 CDK4 CDKN2A KDR KIT PDGFRA PDGFRB

Molecular functions related to Fibrosarcoma of Bone according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.91 CDK4 KDR KIT PDGFRA PDGFRB
2 kinase activity GO:0016301 9.88 CDK4 CDKN2A KDR KIT PDGFRA PDGFRB
3 nucleotide binding GO:0000166 9.83 CDK4 CHD1L KIT PDGFRA PDGFRB
4 Ras guanyl-nucleotide exchange factor activity GO:0005088 9.73 KIT PDGFRA PDGFRB
5 protein tyrosine kinase activity GO:0004713 9.67 KDR KIT PDGFRA PDGFRB
6 phosphatidylinositol-4,5-bisphosphate 3-kinase activity GO:0046934 9.65 KIT PDGFRA PDGFRB
7 MAP kinase kinase kinase activity GO:0004709 9.62 KDR KIT PDGFRA PDGFRB
8 mitogen-activated protein kinase kinase binding GO:0031434 9.56 KDR KIT PDGFRA PDGFRB
9 SUMO transferase activity GO:0019789 9.55 CDKN2A MDM2
10 platelet-derived growth factor receptor binding GO:0005161 9.54 PDGFRA PDGFRB
11 platelet-derived growth factor binding GO:0048407 9.52 PDGFRA PDGFRB
12 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.49 KDR KIT
13 vascular endothelial growth factor-activated receptor activity GO:0005021 9.46 KDR PDGFRA
14 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.46 KDR KIT PDGFRA PDGFRB
15 growth factor binding GO:0019838 9.26 KDR KIT PDGFRA PDGFRB
16 vascular endothelial growth factor binding GO:0038085 8.8 KDR PDGFRA PDGFRB

Sources for Fibrosarcoma of Bone

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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