MCID: FBR013
MIFTS: 25

Fibrosarcomatous Osteosarcoma

Categories: Cancer diseases, Bone diseases

Aliases & Classifications for Fibrosarcomatous Osteosarcoma

MalaCards integrated aliases for Fibrosarcomatous Osteosarcoma:

Name: Fibrosarcomatous Osteosarcoma 12 15
Fibroblastic Osteosarcoma 12 55 73
Fibrosarcomatous Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7603
NCIt 50 C4020
SNOMED-CT 68 12690005
UMLS 73 C0279602

Summaries for Fibrosarcomatous Osteosarcoma

MalaCards based summary : Fibrosarcomatous Osteosarcoma, also known as fibroblastic osteosarcoma, is related to papillary cystadenocarcinoma and periosteal osteogenic sarcoma, and has symptoms including pain An important gene associated with Fibrosarcomatous Osteosarcoma is BGLAP (Bone Gamma-Carboxyglutamate Protein). The drugs Cyproheptadine and Histamine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Fibrosarcomatous Osteosarcoma

Diseases related to Fibrosarcomatous Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 papillary cystadenocarcinoma 9.6 BGLAP SPARC
2 periosteal osteogenic sarcoma 9.6 BGLAP SPARC
3 osseous heteroplasia, progressive 9.5 BGLAP SPARC
4 osteofibrous dysplasia 9.5 BGLAP SPARC
5 fibrous dysplasia 9.4 BGLAP SPARC
6 brittle bone disorder 9.3 BGLAP SPARC
7 bone disease 9.2 BGLAP SPARC
8 osteoporosis 9.0 BGLAP SPARC

Graphical network of the top 20 diseases related to Fibrosarcomatous Osteosarcoma:



Diseases related to Fibrosarcomatous Osteosarcoma

Symptoms & Phenotypes for Fibrosarcomatous Osteosarcoma

UMLS symptoms related to Fibrosarcomatous Osteosarcoma:


pain

GenomeRNAi Phenotypes related to Fibrosarcomatous Osteosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.23 BGLAP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.23 BGLAP SPARC
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.23 BGLAP
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.23 BGLAP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.23 SPARC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.23 SPARC
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.23 SPARC

Drugs & Therapeutics for Fibrosarcomatous Osteosarcoma

Drugs for Fibrosarcomatous Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cyproheptadine Approved Phase 3 129-03-3 2913
2
Histamine Approved, Investigational Phase 3 75614-87-8, 51-45-6 774
3
Histamine Phosphate Phase 3 51-74-1 65513
4 Serotonin Agents Phase 3
5 Serotonin Antagonists Phase 3
6 Gastrointestinal Agents Phase 3
7 Neurotransmitter Agents Phase 3
8 Histamine Antagonists Phase 3
9 Histamine H1 Antagonists Phase 3
10 Dermatologic Agents Phase 3
11 Anti-Allergic Agents Phase 3
12 Antipruritics Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Lenograstim Approved, Investigational Phase 2 135968-09-1
15
Etoposide Approved Phase 2 33419-42-0 36462
16
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
17
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
18
Ifosfamide Approved Phase 2 3778-73-2 3690
19
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
20
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
21
Sunitinib Approved, Investigational Phase 2 341031-54-7, 557795-19-4 5329102
22
Dactinomycin Approved, Investigational Phase 2 50-76-0 2019 457193
23
Epirubicin Approved Phase 2 56420-45-2 41867
24
Doxil Approved June 1999 Phase 2 31703
25 Imatinib Mesylate Phase 2 220127-57-1 123596
26
Isophosphamide mustard Phase 2 0
27 Alkylating Agents Phase 2
28 Topoisomerase Inhibitors Phase 2
29 Nucleic Acid Synthesis Inhibitors Phase 2
30 Angiogenesis Inhibitors Phase 2
31 Angiogenesis Modulating Agents Phase 2
32 Anti-Bacterial Agents Phase 2
33 Antibiotics, Antitubercular Phase 2
34 Etoposide phosphate Phase 2
35 Immunosuppressive Agents Phase 2
36 Anti-Infective Agents Phase 2
37 Protein Kinase Inhibitors Phase 2
38 Antirheumatic Agents Phase 2
39 Antimitotic Agents Phase 2
40 Antineoplastic Agents, Alkylating Phase 2
41 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
3 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
4 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2 imatinib mesylate

Search NIH Clinical Center for Fibrosarcomatous Osteosarcoma

Genetic Tests for Fibrosarcomatous Osteosarcoma

Anatomical Context for Fibrosarcomatous Osteosarcoma

MalaCards organs/tissues related to Fibrosarcomatous Osteosarcoma:

41
Bone

Publications for Fibrosarcomatous Osteosarcoma

Articles related to Fibrosarcomatous Osteosarcoma:

# Title Authors Year
1
Pulmonary artery tumor embolism in a patient with previous fibroblastic osteosarcoma. ( 23706436 )
2013
2
Fibroblastic osteosarcoma of the mandible. ( 11828333 )
2002

Variations for Fibrosarcomatous Osteosarcoma

Expression for Fibrosarcomatous Osteosarcoma

Search GEO for disease gene expression data for Fibrosarcomatous Osteosarcoma.

Pathways for Fibrosarcomatous Osteosarcoma

GO Terms for Fibrosarcomatous Osteosarcoma

Cellular components related to Fibrosarcomatous Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 vesicle GO:0031982 8.62 BGLAP SPARC

Biological processes related to Fibrosarcomatous Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to ethanol GO:0045471 9.37 BGLAP SPARC
2 ossification GO:0001503 9.32 BGLAP SPARC
3 response to glucocorticoid GO:0051384 9.26 BGLAP SPARC
4 bone development GO:0060348 9.16 BGLAP SPARC
5 cellular response to growth factor stimulus GO:0071363 8.96 BGLAP SPARC
6 response to gravity GO:0009629 8.62 BGLAP SPARC

Molecular functions related to Fibrosarcomatous Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 8.62 BGLAP SPARC

Sources for Fibrosarcomatous Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....