MCID: FBR013
MIFTS: 38

Fibrosarcomatous Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Fibrosarcomatous Osteosarcoma

MalaCards integrated aliases for Fibrosarcomatous Osteosarcoma:

Name: Fibrosarcomatous Osteosarcoma 12 15
Fibroblastic Osteosarcoma 12 55 73
Fibrosarcomatous Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7603
NCIt 50 C4020
SNOMED-CT 68 12690005
UMLS 73 C0279602

Summaries for Fibrosarcomatous Osteosarcoma

MalaCards based summary : Fibrosarcomatous Osteosarcoma, also known as fibroblastic osteosarcoma, is related to chondroblastic osteosarcoma and conventional central osteosarcoma, and has symptoms including pain An important gene associated with Fibrosarcomatous Osteosarcoma is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways are PI3K-Akt signaling pathway and Degradation of the extracellular matrix. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Fibrosarcomatous Osteosarcoma

Diseases related to Fibrosarcomatous Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 chondroblastic osteosarcoma 10.2 BGLAP NELL1
2 conventional central osteosarcoma 10.2 BGLAP SPARC
3 bone osteosarcoma 10.2 BGLAP SPARC
4 osteoblastoma 10.2 NELL1 SPARC
5 periosteal osteogenic sarcoma 10.2 BGLAP SPARC
6 osseous heteroplasia, progressive 10.1 BGLAP SPARC
7 fibrous dysplasia 10.1 BGLAP IBSP SPARC
8 brittle bone disorder 10.1 BGLAP IBSP SPARC
9 osteogenic sarcoma 10.1
10 dentin dysplasia, type ii 10.1 IBSP SPP1
11 dentin dysplasia 10.1 IBSP SPP1
12 hemarthrosis 10.0 BGLAP SPP1
13 hypophosphatasia, adult 10.0 BGLAP SPP1
14 mccune-albright syndrome 10.0 BGLAP IBSP
15 tendinitis 10.0 PDGFB SPP1
16 papillary cystadenocarcinoma 10.0 BGLAP SPARC SPP1
17 bone resorption disease 10.0 BGLAP IBSP SPP1
18 optic nerve neoplasm 10.0 KRT5 LOX
19 ankylosis 10.0 BGLAP IBSP
20 aortic valve disease 2 9.9 IBSP SPARC SPP1
21 nephrolithiasis, calcium oxalate 9.9 IBSP SPP1
22 pleural cancer 9.9 KRT5 SPP1
23 malignant biphasic mesothelioma 9.9 FUT4 KRT5
24 granulomatous gastritis 9.9 FUT4 SPP1
25 epidural neoplasm 9.9 FUT4 KRT5
26 pulmonary fibrosis, idiopathic 9.9 PDGFB SPARC SPP1
27 bone disease 9.9 BGLAP IBSP SPARC SPP1
28 osteofibrous dysplasia 9.8 BGLAP KRT5 SPARC SPP1
29 aneurysmal bone cysts 9.8
30 osteomyelitis 9.8
31 primary hyperparathyroidism 9.8
32 hyperparathyroidism 9.8
33 osteoporosis 9.7 BGLAP IBSP LOX SPARC SPP1

Graphical network of the top 20 diseases related to Fibrosarcomatous Osteosarcoma:



Diseases related to Fibrosarcomatous Osteosarcoma

Symptoms & Phenotypes for Fibrosarcomatous Osteosarcoma

UMLS symptoms related to Fibrosarcomatous Osteosarcoma:


pain

GenomeRNAi Phenotypes related to Fibrosarcomatous Osteosarcoma according to GeneCards Suite gene sharing:

26 (show all 16)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-119 9.64 BGLAP
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.64 NELL1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.64 ATXN3 BGLAP NELL1 SPARC
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.64 BGLAP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.64 BGLAP
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.64 NELL1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.64 ATXN3
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.64 ATXN3
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-22 9.64 SPARC
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.64 ATXN3 NELL1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-40 9.64 ATXN3
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-48 9.64 ATXN3
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.64 SPARC
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-62 9.64 ATXN3
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.64 NELL1 SPARC
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-86 9.64 NELL1

MGI Mouse Phenotypes related to Fibrosarcomatous Osteosarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.55 IBSP KRT5 NELL1 SPARC SPP1
2 hematopoietic system MP:0005397 9.5 ATXN3 CSF3 FUT4 IBSP PDGFB SPARC
3 integument MP:0010771 9.1 CSF3 KRT5 LOX PDGFB SPARC SPP1

Drugs & Therapeutics for Fibrosarcomatous Osteosarcoma

Drugs for Fibrosarcomatous Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Serotonin Agents Phase 3
4 Anti-Allergic Agents Phase 3
5 Serotonin Antagonists Phase 3
6 Histamine H1 Antagonists Phase 3
7
Histamine Phosphate Phase 3 51-74-1 65513
8 Antipruritics Phase 3
9 Neurotransmitter Agents Phase 3
10 Dermatologic Agents Phase 3
11 Histamine Antagonists Phase 3
12 Gastrointestinal Agents Phase 3
13
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
14
Lenograstim Approved, Investigational Phase 2 135968-09-1
15
Dactinomycin Approved, Investigational Phase 2 50-76-0 457193 2019
16
Carboplatin Approved Phase 2 41575-94-4 10339178 38904 498142
17
Cyclophosphamide Approved, Investigational Phase 2 6055-19-2, 50-18-0 2907
18
Vincristine Approved, Investigational Phase 2 57-22-7, 2068-78-2 5978
19
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
20
Epirubicin Approved Phase 2 56420-45-2 41867
21
Ifosfamide Approved Phase 2 3778-73-2 3690
22
Etoposide Approved Phase 2 33419-42-0 36462
23
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
24
Doxil Approved June 1999 Phase 2 31703
25
Isophosphamide mustard Phase 2 0
26 Immunosuppressive Agents Phase 2
27 Antineoplastic Agents, Phytogenic Phase 2
28 Nucleic Acid Synthesis Inhibitors Phase 2
29 Antineoplastic Agents, Alkylating Phase 2
30 Immunologic Factors Phase 2
31 Etoposide phosphate Phase 2
32 Alkylating Agents Phase 2
33 Anti-Bacterial Agents Phase 2
34 Topoisomerase Inhibitors Phase 2
35 Antibiotics, Antitubercular Phase 2
36 Antimitotic Agents Phase 2
37 Antirheumatic Agents Phase 2
38 Anti-Infective Agents Phase 2
39 Angiogenesis Modulating Agents Phase 2
40 Angiogenesis Inhibitors Phase 2
41 Imatinib Mesylate Phase 2 220127-57-1 123596
42 Protein Kinase Inhibitors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Combination Chemotherapy in Treating Children With Metastatic Rhabdomyosarcoma or Other Malignant Mesenchymal Tumors Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate
3 Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
4 Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma Completed NCT00031915 Phase 2 imatinib mesylate

Search NIH Clinical Center for Fibrosarcomatous Osteosarcoma

Genetic Tests for Fibrosarcomatous Osteosarcoma

Anatomical Context for Fibrosarcomatous Osteosarcoma

MalaCards organs/tissues related to Fibrosarcomatous Osteosarcoma:

41
Bone

Publications for Fibrosarcomatous Osteosarcoma

Articles related to Fibrosarcomatous Osteosarcoma:

(show all 16)
# Title Authors Year
1
Low-grade central fibroblastic osteosarcoma may be differentiated from its mimicker desmoplastic fibroma by genetic analysis. ( 30159138 )
2018
2
Fibroblastic osteosarcoma with epithelioid and squamous differentiation in a dog. ( 29629646 )
2018
3
Primary Fibroblastic Osteosarcoma of the Lumbar Vertebra on Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. ( 29643686 )
2018
4
Primary, cardiac, fibroblastic osteosarcoma: A case report. ( 29505531 )
2018
5
Chondroblastic and fibroblastic osteosarcoma of the jaws: Report of two cases and review of literature. ( 28393823 )
2017
6
Malignant Transformation of an Aneurysmal Bone Cyst to Fibroblastic Osteosarcoma. ( 27737291 )
2016
7
Fibroblastic osteosarcoma in a lion (Panthera leo). ( 26623330 )
2014
8
Pulmonary artery tumor embolism in a patient with previous fibroblastic osteosarcoma. ( 23706436 )
2013
9
High-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw. ( 23482406 )
2011
10
Primary hyperparathyroidism and osteosarcoma: examination of a large cohort identifies three cases of fibroblastic osteosarcoma. ( 16059628 )
2005
11
Fibroblastic osteosarcoma arising in chronic osteomyelitis. ( 12623051 )
2003
12
Fibroblastic osteosarcoma of the mandible. ( 11828333 )
2002
13
Extraskeletal fibroblastic osteosarcoma in a rabbit (Oryctolagus cuniculus). ( 11570390 )
2001
14
High-dose methotrexate in fibroblastic osteosarcoma. ( 11793640 )
2001
15
Fibroblastic osteosarcoma in a chamois (Rupicapra pyrenaica parva). ( 10074665 )
1999
16
Mandibular fibroblastic osteosarcoma in a three-month-old dog. ( 8856893 )
1996

Variations for Fibrosarcomatous Osteosarcoma

Expression for Fibrosarcomatous Osteosarcoma

Search GEO for disease gene expression data for Fibrosarcomatous Osteosarcoma.

Pathways for Fibrosarcomatous Osteosarcoma

GO Terms for Fibrosarcomatous Osteosarcoma

Cellular components related to Fibrosarcomatous Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 BGLAP CSF3 IBSP LOX PDGFB SPARC
2 extracellular region GO:0005576 9.56 BGLAP CSF3 IBSP LOX NELL1 PDGFB
3 vesicle GO:0031982 8.92 BGLAP IBSP SPARC SPP1

Biological processes related to Fibrosarcomatous Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heart development GO:0007507 9.65 LOX PDGFB SPARC
2 response to ethanol GO:0045471 9.54 BGLAP CSF3 SPARC
3 osteoblast differentiation GO:0001649 9.5 BGLAP IBSP SPP1
4 bone mineralization GO:0030282 9.46 BGLAP IBSP
5 extracellular matrix organization GO:0030198 9.46 IBSP PDGFB SPARC SPP1
6 response to steroid hormone GO:0048545 9.43 LOX SPP1
7 response to vitamin D GO:0033280 9.4 BGLAP SPP1
8 response to gravity GO:0009629 9.26 BGLAP SPARC
9 biomineral tissue development GO:0031214 9.13 BGLAP IBSP SPP1
10 cellular response to growth factor stimulus GO:0071363 8.92 BGLAP IBSP PDGFB SPARC

Molecular functions related to Fibrosarcomatous Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix binding GO:0050840 8.62 SPARC SPP1

Sources for Fibrosarcomatous Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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