MCID: FBR013
MIFTS: 30

Fibrosarcomatous Osteosarcoma

Categories: Bone diseases, Cancer diseases

Aliases & Classifications for Fibrosarcomatous Osteosarcoma

MalaCards integrated aliases for Fibrosarcomatous Osteosarcoma:

Name: Fibrosarcomatous Osteosarcoma 12 15
Fibroblastic Osteosarcoma 12 54 70
Fibrosarcomatous Osteogenic Sarcoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:7603
NCIt 50 C4020
SNOMED-CT 67 12690005
UMLS 70 C0279602

Summaries for Fibrosarcomatous Osteosarcoma

MalaCards based summary : Fibrosarcomatous Osteosarcoma, also known as fibroblastic osteosarcoma, is related to bone osteosarcoma and chondroblastic osteosarcoma, and has symptoms including pain An important gene associated with Fibrosarcomatous Osteosarcoma is BGLAP (Bone Gamma-Carboxyglutamate Protein), and among its related pathways/superpathways is ECM proteoglycans. The drugs Histamine and Cyproheptadine have been mentioned in the context of this disorder. Affiliated tissues include bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Fibrosarcomatous Osteosarcoma

Diseases related to Fibrosarcomatous Osteosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 35)
# Related Disease Score Top Affiliating Genes
1 bone osteosarcoma 29.9 SPARC FAM180A BGLAP
2 chondroblastic osteosarcoma 29.7 SERPINA3 MATN4 FAM180A BGLAP
3 osteogenic sarcoma 10.6
4 tooth resorption 10.2 SERPINA3 BGLAP
5 extraosseous osteosarcoma 10.2 SPARC BGLAP
6 myositis ossificans 10.2 SPARC BGLAP
7 clear cell chondrosarcoma 10.1 SPARC SERPINA3
8 bone benign neoplasm 10.1 SERPINA3 BGLAP
9 osteofibrous dysplasia 10.1 SPARC BGLAP
10 fibrous dysplasia 10.1 SPARC BGLAP
11 osteoblastoma 10.1 SPARC BGLAP
12 benign giant cell tumor 10.1 SERPINA3 BGLAP
13 osteoporosis, juvenile 10.0 SPARC BGLAP
14 papillary cystadenocarcinoma 10.0 SPARC SERPINA3 BGLAP
15 osseous heteroplasia, progressive 10.0 SPARC BGLAP
16 conventional central osteosarcoma 10.0 SPARC SERPINA3 FAM180A
17 teeth hard tissue disease 10.0 SERPINA3 BGLAP
18 sarcoma, synovial 9.9
19 aneurysmal bone cysts 9.9
20 hyperparathyroidism 3 9.9
21 leukemia, acute lymphoblastic 9.9
22 fibroma 9.9
23 bone disease 9.9
24 osteomyelitis 9.9
25 primary hyperparathyroidism 9.9
26 hyperparathyroidism 9.9
27 bone inflammation disease 9.9
28 fibrosarcoma 9.9
29 t-cell acute lymphoblastic leukemia 9.9
30 posttransplant acute limbic encephalitis 9.9
31 rare tumor 9.9
32 mccune-albright syndrome 9.8 SPARC BGLAP
33 cleidocranial dysplasia 9.8 NELL1 DLX5 BGLAP
34 odontochondrodysplasia 9.8 SPARC DLX5 BGLAP
35 bone development disease 9.7 SERPINA3 NELL1 DLX5 BGLAP

Graphical network of the top 20 diseases related to Fibrosarcomatous Osteosarcoma:



Diseases related to Fibrosarcomatous Osteosarcoma

Symptoms & Phenotypes for Fibrosarcomatous Osteosarcoma

UMLS symptoms related to Fibrosarcomatous Osteosarcoma:


pain

GenomeRNAi Phenotypes related to Fibrosarcomatous Osteosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-105 9.4 NELL1 SPARC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-126 9.4 BGLAP
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-128 9.4 SPARC
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-16 9.4 BGLAP
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.4 SPARC
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.4 BGLAP SPARC
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-181 9.4 BGLAP
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-27 9.4 NELL1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.4 SPARC
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 9.4 SPARC

Drugs & Therapeutics for Fibrosarcomatous Osteosarcoma

Drugs for Fibrosarcomatous Osteosarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Histamine Approved, Investigational Phase 3 51-45-6, 75614-87-8 774
2
Cyproheptadine Approved Phase 3 129-03-3 2913
3 Gastrointestinal Agents Phase 3
4 Neurotransmitter Agents Phase 3
5 Dermatologic Agents Phase 3
6
Histamine Phosphate Phase 3 51-74-1 65513
7 Histamine H1 Antagonists Phase 3
8 Histamine Antagonists Phase 3
9 Anti-Allergic Agents Phase 3
10
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
11
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
12
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
13
Etoposide Approved Phase 2 33419-42-0 36462
14
Epirubicin Approved Phase 2 56420-45-2 41867
15
Dactinomycin Approved, Investigational Phase 2 50-76-0 2019 457193
16
Ifosfamide Approved Phase 2 3778-73-2 3690
17
Lenograstim Approved, Investigational Phase 2 135968-09-1
18
Doxorubicin Approved, Investigational Phase 2 23214-92-8 31703
19
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
20
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
21 Imatinib Mesylate Phase 2 220127-57-1 123596
22 Protein Kinase Inhibitors Phase 2
23 Angiogenesis Inhibitors Phase 2
24 Immunosuppressive Agents Phase 2
25 Tubulin Modulators Phase 2
26 Antibiotics, Antitubercular Phase 2
27
Liposomal doxorubicin Phase 2 31703
28 Alkylating Agents Phase 2
29 Immunologic Factors Phase 2
30 Anti-Infective Agents Phase 2
31 Antirheumatic Agents Phase 2
32 Etoposide phosphate Phase 2
33 Anti-Bacterial Agents Phase 2
34 Antimitotic Agents Phase 2
35
Isophosphamide mustard Phase 2 100427

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk Terminated NCT01132547 Phase 3 cyproheptadine hydrochloride
2 Phase II Trial of Gleevec (Formerly Known as STI571) in Patients With Soft Tissue and Bone Sarcomas: A Multi-Disciplinary Trial of the North American Sarcoma Study Group of the Connective Tissue Oncology Society Completed NCT00031915 Phase 2 imatinib mesylate
3 A Multicenter Phase II Study of Continuous Dosing of Sunitinib (Sutent®, SU11248) in Non-GIST Sarcomas Completed NCT00474994 Phase 2 sunitinib malate
4 MMT 98 Study For Metastatic Disease Rhabdomyosarcoma And Other Malignant Soft Tissue Sarcoma Of Childhood Completed NCT00025441 Phase 2 carboplatin;cyclophosphamide;doxorubicin hydrochloride;epirubicin hydrochloride;etoposide;ifosfamide;vincristine sulfate

Search NIH Clinical Center for Fibrosarcomatous Osteosarcoma

Genetic Tests for Fibrosarcomatous Osteosarcoma

Anatomical Context for Fibrosarcomatous Osteosarcoma

MalaCards organs/tissues related to Fibrosarcomatous Osteosarcoma:

40
Bone

Publications for Fibrosarcomatous Osteosarcoma

Articles related to Fibrosarcomatous Osteosarcoma:

(show top 50) (show all 58)
# Title Authors PMID Year
1
Long-term survival in a patient with Hutchinson-Gilford progeria syndrome and osteosarcoma: A case report. 61
33585632 2021
2
PLK2 modulation of enriched TAp73 affects osteogenic differentiation and prognosis in human osteosarcoma. 61
32349184 2020
3
Characterization of five newly derived canine osteosarcoma cell lines. 61
31640712 2019
4
Radiographic manifestations of fibroblastic osteosarcoma: A diagnostic challenge. 61
31583207 2019
5
Extensor Mechanism Allograft in Osteosarcoma of the Patella: A Case Report. 61
31365362 2019
6
Pan-Cytokeratin Positive Fibroblastic Osteosarcoma of Jaw: An Extremely Rare Entity in a Pediatric Patient. 61
31019374 2019
7
Fibroblastic osteosarcoma with epithelioid and squamous differentiation in a dog. 61
29629646 2018
8
Primary Fibroblastic Osteosarcoma of the Lumbar Vertebra on Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography. 61
29643686 2018
9
Primary, cardiac, fibroblastic osteosarcoma: A case report. 61
29505531 2018
10
Low-grade central fibroblastic osteosarcoma may be differentiated from its mimicker desmoplastic fibroma by genetic analysis. 61
30159138 2018
11
Chondroblastic and fibroblastic osteosarcoma of the jaws: Report of two cases and review of literature. 61
28393823 2017
12
Malignant Transformation of an Aneurysmal Bone Cyst to Fibroblastic Osteosarcoma. 61
27737291 2016
13
NELL-1 expression in benign and malignant bone tumors. 61
25791475 2015
14
Osteosarcomas of jaw: experience of a single centre. 61
24780088 2015
15
[Bone tumours in lizards and snakes. A rare clinical finding]. 61
25609210 2015
16
Fibroblastic osteosarcoma in a lion (Panthera leo). 61
26623330 2014
17
Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA. 61
23486187 2013
18
Pulmonary artery tumor embolism in a patient with previous fibroblastic osteosarcoma. 61
23706436 2013
19
Expression of EBV-encoded oncogenes and EBV-like virions in multiple canine tumors. 61
23380461 2013
20
Spirocercosis in owned and stray dogs in Grenada. 61
22841904 2012
21
mRNA expression profiles of primary high-grade central osteosarcoma are preserved in cell lines and xenografts. 61
21933437 2011
22
High-grade chondroblastic and fibroblastic osteosarcoma of the upper jaw. 61
23482406 2011
23
Eosinophilic granuloma of bilateral humerus with unusual diagnostic process. 61
22017640 2011
24
[Conservative surgery as an alternative treatment of a knee osteosarcoma in the presence of a pathological fracture]. 61
20377001 2009
25
Osteosarcoma multidisciplinary approach to the management from the pathologist's perspective. 61
20213386 2009
26
Fibroblastic type osteosarcoma of the ulna: a case report of a tumor in a rare location with atypical imaging findings. 61
19182508 2009
27
Sequential Ewing's sarcoma and osteosarcoma. 61
18841070 2008
28
Oesophageal sarcomas in dogs: histological and clinical evaluation. 61
17804268 2008
29
Dedifferentiated parosteal osteosarcoma with giant cell tumor component. 61
18256826 2008
30
Equine osteosarcoma: a series of 8 cases. 61
17317809 2007
31
Osteosarcoma of the proximal fibula. An analysis of 13 cases in the northern Japan. 61
18484078 2007
32
Clinicopathologic features, treatment, and prognosis of postirradiation osteosarcoma in patients with nasopharyngeal cancer. 61
16148697 2005
33
Primary hyperparathyroidism and osteosarcoma: examination of a large cohort identifies three cases of fibroblastic osteosarcoma. 61
16059628 2005
34
Case reports: malignant transformation of aneurysmal bone cysts. 61
16131903 2005
35
Dedifferentiated parosteal osteosarcoma: the experience of the Rizzoli Institute. 61
15852358 2005
36
Genetic analysis of fibrosarcoma of bone, a rare tumour entity closely related to osteosarcoma and malignant fibrous histiocytoma of bone. 61
15540465 2004
37
Osteosarcoma of the rib. 61
15226567 2004
38
Regression of metastatic osteosarcoma following non-myeloablative stem cell transplantation. A case report. 61
12745285 2003
39
Fibroblastic osteosarcoma arising in chronic osteomyelitis. 61
12623051 2003
40
Osteosarcoma of bone in apatient with primary hyperparathyroidism: a case report. 61
12510819 2003
41
Fibroblastic osteosarcoma of the mandible. 61
11828333 2002
42
High-dose methotrexate in fibroblastic osteosarcoma. 61
11793640 2001
43
Extraskeletal fibroblastic osteosarcoma in a rabbit (Oryctolagus cuniculus). 61
11570390 2001
44
[The expression of noncollagenous proteins and the tumor differentiation in oral maxillofacial osteosarcoma]. 61
14994076 2001
45
Dedifferentiated parosteal osteosarcoma with rhabdomyosarcomatous differentiation. 61
10525797 1999
46
Cd 34+ cells and clonogenicity of peripheral blood stem cells during chemotherapy treatment in association with granulocyte colony stimulating factor in osteosarcoma. 61
10465132 1999
47
Fibroblastic osteosarcoma in a chamois (Rupicapra pyrenaica parva). 61
10074665 1999
48
Phalangeal intraosseous well-differentiated osteosarcoma of the hand. 61
9083523 1997
49
Mandibular fibroblastic osteosarcoma in a three-month-old dog. 61
8856893 1996
50
Analysis of the presence of osteocalcin, S-100 protein, and proliferating cell nuclear antigen in cells of various types of osteosarcomas. 61
8922947 1996

Variations for Fibrosarcomatous Osteosarcoma

Expression for Fibrosarcomatous Osteosarcoma

Search GEO for disease gene expression data for Fibrosarcomatous Osteosarcoma.

Pathways for Fibrosarcomatous Osteosarcoma

Pathways related to Fibrosarcomatous Osteosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.38 SPARC MATN4

GO Terms for Fibrosarcomatous Osteosarcoma

Cellular components related to Fibrosarcomatous Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.5 SPARC SERPINA3 NPNT NELL1 MATN4 FAM180A
2 platelet alpha granule lumen GO:0031093 9.16 SPARC SERPINA3
3 collagen-containing extracellular matrix GO:0062023 8.92 SPARC SERPINA3 NPNT MATN4

Biological processes related to Fibrosarcomatous Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of osteoblast differentiation GO:0045669 9.37 NPNT NELL1
2 extracellular matrix organization GO:0030198 9.33 SPARC NPNT MATN4
3 response to glucocorticoid GO:0051384 9.32 SPARC BGLAP
4 response to calcium ion GO:0051592 9.26 SPARC S100A16
5 ossification GO:0001503 9.13 SPARC DLX5 BGLAP
6 response to gravity GO:0009629 8.62 SPARC BGLAP

Molecular functions related to Fibrosarcomatous Osteosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.1 SPARC S100A16 NPNT NELL1 MATN4 BGLAP

Sources for Fibrosarcomatous Osteosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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