MCID: FBR016
MIFTS: 26

Fibrosclerosis of Breast

Categories: Cancer diseases, Reproductive diseases

Aliases & Classifications for Fibrosclerosis of Breast

MalaCards integrated aliases for Fibrosclerosis of Breast:

Name: Fibrosclerosis of Breast 12 15 32
Fibrosis of the Breast 12
Breast Fibrosis 17

Classifications:



External Ids:

Disease Ontology 12 DOID:10353
ICD9CM 34 610.3
NCIt 50 C3660
SNOMED-CT 67 29070004
ICD10 32 N60.3
UMLS 70 C0156318

Summaries for Fibrosclerosis of Breast

Disease Ontology : 12 A non-proliferative fibrocystic change of the breast that contains scar tissue.

MalaCards based summary : Fibrosclerosis of Breast, also known as fibrosis of the breast, is related to breast disease and fibrosis of extraocular muscles, congenital, 1. An important gene associated with Fibrosclerosis of Breast is XRCC1 (X-Ray Repair Cross Complementing 1), and among its related pathways/superpathways are Effects of PIP2 hydrolysis and Hypothesized Pathways in Pathogenesis of Cardiovascular Disease. The drugs Pravastatin and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include breast, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

Related Diseases for Fibrosclerosis of Breast

Diseases related to Fibrosclerosis of Breast via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 breast disease 10.0
2 fibrosis of extraocular muscles, congenital, 1 9.9
3 mastitis 9.9
4 infant gynecomastia 9.9
5 gynecomastia 9.9
6 breast fibroadenoma 9.9
7 papilloma 9.9
8 diabetic mastopathy 9.9
9 lig4 syndrome 9.9 XRCC1 LIG4
10 pulmonary arterial hypertension associated with congenital heart disease 9.8 ENG CCN2
11 differentiated thyroid carcinoma 9.8 XRCC1 LIG4
12 trachoma 9.8 ENG CCN2
13 vascular disease 9.7
14 systemic scleroderma 9.7
15 renal fibrosis 9.6 ENG CCN2

Graphical network of the top 20 diseases related to Fibrosclerosis of Breast:



Diseases related to Fibrosclerosis of Breast

Symptoms & Phenotypes for Fibrosclerosis of Breast

GenomeRNAi Phenotypes related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-1 9.1 LIG4
2 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-2 9.1 CCN2 LIG4 RASGRP1
3 Increased viability with MLN4924 (a NAE inhibitor) GR00250-A-3 9.1 LIG4 XRCC1

Drugs & Therapeutics for Fibrosclerosis of Breast

Drugs for Fibrosclerosis of Breast (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pravastatin Approved Phase 3 81093-37-0 54687
2 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 3
3 Antimetabolites Phase 3
4 Lipid Regulating Agents Phase 3
5 Anticholesteremic Agents Phase 3
6 Hypolipidemic Agents Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Comparative Study of Pravastatin vs Placebo as Primary Prevention of Severe Subcutaneous Breast Fibrosis in Hyper-radiosensitive Identified Patients With Breast Cancer Recruiting NCT04385433 Phase 3 EXPERIMENTAL ARM
2 Improving Theempowerment in Patients With Severe Breast Fibrosis Radio-induced Treated by Pravastatin : Benefit of e-PROs (Electronic " Patient Reported Outcome ") on Breast-related Quality of Life Recruiting NCT04356209 Phase 2 Pravastatin
3 The PhysioTouch, A Novel Treatment for Radiation Fibrosis Syndrome in Breast Cancer Patients Withdrawn NCT03496909

Search NIH Clinical Center for Fibrosclerosis of Breast

Genetic Tests for Fibrosclerosis of Breast

Anatomical Context for Fibrosclerosis of Breast

MalaCards organs/tissues related to Fibrosclerosis of Breast:

40
Breast

Publications for Fibrosclerosis of Breast

Articles related to Fibrosclerosis of Breast:

(show all 28)
# Title Authors PMID Year
1
Stromal Fibrosis of the Breast: A Spectrum of Benign to Malignant Imaging Appearances. 61
30886748 2019
2
Underdiagnosed and disfiguring - Radiation-induced morphea following breast cancer treatment. 61
29635112 2018
3
XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients. 61
26072091 2015
4
Stromal fibrosis of the breast: outcome analysis. 61
23963149 2014
5
Focal fibrosis of the breast diagnosed by core needle biopsy under imaging guidance. 61
23539939 2013
6
Fibrotic lesions of the breast: radiological findings and core-neddle biopsy results. 61
21071162 2011
7
MRI features of stromal fibrosis of the breast with histopathologic correlation. 61
21862821 2011
8
Prospective study validating inter- and intraobserver variability of tissue compliance meter in breast tissue of healthy volunteers: potential implications for patients with radiation-induced fibrosis of the breast. 61
20395064 2011
9
Quantitative assessment of radiation-induced fibrosis of the breast with tissue compliance meter, palpation, and radiological imaging: preliminary results. 61
19824999 2009
10
Neoadjuvant interstitial high-dose-rate (HDR) brachytherapy combined with systemic chemotherapy in patients with breast cancer. 61
16404517 2006
11
Focal fibrosis of the breast diagnosed by a sonographically guided core biopsy of nonpalpable lesions: imaging findings and clinical relevance. 61
16179621 2005
12
Stromal fibrosis of the breast. 61
11517049 2001
13
[Radiotherapy of locally advanced breast carcinoma in elderly female patients]. 61
11255686 2000
14
Focal fibrosis of the breast: imaging characteristics and histopathologic correlation. 61
10887257 2000
15
Focal fibrosis of the breast in diabetes. 61
10701645 2000
16
TGF-beta1 levels in pre-treatment plasma identify breast cancer patients at risk of developing post-radiotherapy fibrosis. 61
10096248 1999
17
Lymphocytic mastitis and fibrosis of the breast in long-standing insulin-dependent diabetics. A histopathologic study on diabetic mastopathy and report of ten cases. 61
9269908 1997
18
"Diabetic mastopathy" in the male breast--a special type of gynecomastia. A comparative study of lymphocytic mastitis and gynecomastia. 61
9198105 1997
19
Tissue eosinophilia and eosinophil degranulation in syndromes associated with fibrosis. 61
1739138 1992
20
Fibrosis of the breast with papillomatosis and calcifications. 61
2277021 1990
21
Inflammatory carcinoma of the breast: treatment results on 107 patients. 61
2753755 1989
22
[Side effects and complications in breast-saving therapy of breast cancer]. 61
2737432 1989
23
Correlation between non-toxic goitre and benign mastopathia. The result of a survey in 477 middle-aged women. 61
3604754 1987
24
[Fibrosis of the breast. A study of 50 women with a control group]. 61
6645908 1983
25
Irradiation with external beam and interstitial radioactive implant as primary treatment for early carcinoma of the breast. 61
6781081 1981
26
Relation between time-dose and local control of operable breast cancer treated by tumorectomy and radiotherapy or by radical radiotherapy alone. 61
101301 1978
27
[Dysplasia of the glandular epithelium in male patients with fibrosis of the breast and their relations to carcinoma]. 61
4884531 1968
28
Fibrosis of the breast. 61
13616820 1959

Variations for Fibrosclerosis of Breast

Expression for Fibrosclerosis of Breast

Search GEO for disease gene expression data for Fibrosclerosis of Breast.

Pathways for Fibrosclerosis of Breast

Pathways related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.46 RASGRP1 DGKA
2 10.02 ENG CCN2

GO Terms for Fibrosclerosis of Breast

Biological processes related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intracellular signal transduction GO:0035556 9.58 RASGRP1 DGKA CCN2
2 positive regulation of JNK cascade GO:0046330 9.46 RASGRP1 CCN2
3 double-strand break repair via nonhomologous end joining GO:0006303 9.43 XRCC1 LIG4
4 DNA biosynthetic process GO:0071897 9.37 LIG4 CCN2
5 positive regulation of protein phosphorylation GO:0001934 9.33 RASGRP1 ENG CCN2
6 positive regulation of collagen biosynthetic process GO:0032967 9.32 ENG CCN2
7 nucleotide-excision repair, DNA gap filling GO:0006297 9.26 XRCC1 LIG4
8 single strand break repair GO:0000012 8.96 XRCC1 LIG4
9 extracellular matrix constituent secretion GO:0070278 8.62 ENG CCN2

Sources for Fibrosclerosis of Breast

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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