Fibrosclerosis of Breast disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Fibrosclerosis of Breast

MalaCards integrated aliases for Fibrosclerosis of Breast:

Name: Fibrosclerosis of Breast ¹² ¹⁵ ³²

Fibrosis of the Breast ¹²

Breast Fibrosis ¹⁷

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Reproductive diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Diseases of the genitourinary system

Disorders of breast

Benign mammary dysplasia

Fibrosclerosis of breast

External Ids:

Disease Ontology ¹² DOID:10353

ICD9CM ³⁴ 610.3

NCIt ⁵⁰ C3660

SNOMED-CT ⁶⁷ 29070004

ICD10 ³² N60.3

EFO ¹⁷ EFO_1000145

UMLS ⁷⁰ C0156318

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Summaries for Fibrosclerosis of Breast

Disease Ontology : ¹² A non-proliferative fibrocystic change of the breast that contains scar tissue.

MalaCards based summary : Fibrosclerosis of Breast, also known as fibrosis of the breast, is related to breast disease and fibrosis of extraocular muscles, congenital, 1. An important gene associated with Fibrosclerosis of Breast is XRCC1 (X-Ray Repair Cross Complementing 1), and among its related pathways/superpathways are Effects of PIP2 hydrolysis and Hypothesized Pathways in Pathogenesis of Cardiovascular Disease. The drugs Pravastatin and Hydroxymethylglutaryl-CoA Reductase Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include breast, and related phenotypes are Increased viability with MLN4924 (a NAE inhibitor) and Increased viability with MLN4924 (a NAE inhibitor)

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Related Diseases for Fibrosclerosis of Breast

Diseases related to Fibrosclerosis of Breast via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)

#	Related Disease	Score	Top Affiliating Genes
1	breast disease	10.0
2	fibrosis of extraocular muscles, congenital, 1	9.9
3	mastitis	9.9
4	infant gynecomastia	9.9
5	gynecomastia	9.9
6	breast fibroadenoma	9.9
7	papilloma	9.9
8	diabetic mastopathy	9.9
9	lig4 syndrome	9.9	XRCC1 LIG4
10	pulmonary arterial hypertension associated with congenital heart disease	9.8	ENG CCN2
11	differentiated thyroid carcinoma	9.8	XRCC1 LIG4
12	trachoma	9.8	ENG CCN2
13	vascular disease	9.7
14	systemic scleroderma	9.7
15	renal fibrosis	9.6	ENG CCN2

Graphical network of the top 20 diseases related to Fibrosclerosis of Breast:

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Symptoms & Phenotypes for Fibrosclerosis of Breast

GenomeRNAi Phenotypes related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-1	9.1	LIG4
2	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-2	9.1	CCN2 LIG4 RASGRP1
3	Increased viability with MLN4924 (a NAE inhibitor)	GR00250-A-3	9.1	LIG4 XRCC1

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Drugs & Therapeutics for Fibrosclerosis of Breast

Drugs for Fibrosclerosis of Breast (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Pravastatin

Approved

Phase 3

81093-37-0

54687

Synonyms:

(+)-(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8ar)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoate

(+)-(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid

(+)-(3R,5R)-3,5-Dihydroxy-7-[(1S,2S,6S,8S,8ar)-6-hydroxy-2-methyl-8-{[(S)-2-methylbutyryl]oxy}-1,2,6,7,8,8a-hexahydro-1-naphthyl]heptanoic acid

(3R,5R)-3,5-dihydroxy-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-{[(2S)-2-methylbutanoyl]oxy}-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoic acid

(3R,5R)-7-[(1S,2S,6S,8S,8aR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid

(3R,5R)-7-[(1S,2S,6S,8S,8AR)-6-hydroxy-2-methyl-8-[(2S)-2-methylbutanoyl]oxy-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]-3,5-dihydroxyheptanoic acid

1,2,6,7,8,8a-hexahydro-beta,delta,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-, (1S-(1alpha(betaS*,deltaS*),2alpha,6alpha,8beta(R*),8aalpha))-1-Naphthaleneheptanoic acid

3beta-Hydroxycompactin

81093-37-0

81131-70-6 (hydrochloride salt)

AC1L1HJL

AC1Q5T3M

Apo pravastatin

Apo-pravastatin

Apotex brand OF pravastatin sodium

Aventis brand OF pravastatin sodium

BIDD:GT0773

BRD-K60511616-236-01-4

Bristacol

Bristol-myers squibb brand OF pravastatin sodium

C01844

C23H36O7

CCRIS 7557

CHEMBL1144

CID54687

Compactin

D08410

DB00175

Elisor

Eptastatin

Esteve brand OF pravastatin sodium

FT-0082682

Juste brand OF pravastatin sodium

KS-5015

Lin pravastatin

Lin-pravastatin

Linson pharma brand OF pravastatin sodium

Lipemol

Liplat

Lipostat

LS-94713

Mevalothin

Mevalotin

Mevastatin

Mevinolin

nchembio.301-comp7

nchembio790-comp15

Nu pravastatin

Nu-pharma brand OF pravastatin sodium

Nu-pravastatin

Oliprevin

Prareduct

Pravachol

Pravacol

Pravaselect

Pravasin

pravastatin

Pravastatin

Pravastatin (INN)

Pravastatin [INN:BAN]

Pravastatin acid

Pravastatin monosodium salt, (6 beta)-isomer

Pravastatin sodium

Pravastatin Sodium

Pravastatin sodium salt

Pravastatin Sodium Salt

Pravastatin tert octylamine salt

Pravastatin tert-octylamine salt

Pravastatin tert-Octylamine Salt

Pravastatin, (6 beta)-isomer

Pravastatina

Pravastatina [Spanish]

Pravastatine

Pravastatine [French]

Pravastatinum

Pravastatinum [Latin]

Pravator

Pravator (TN)

RMS 431

RMS-431

Sankyo brand OF pravastatin sodium

Selectin

Selektine

Selipran

Sodium salt, pravastatin

SQ-31,000

Squibb brand OF pravastatin sodium

UNII-KXO2KT9N0G

Vasten

2

Hydroxymethylglutaryl-CoA Reductase Inhibitors

Phase 3

3

Antimetabolites

Phase 3

4

Lipid Regulating Agents

Phase 3

5

Anticholesteremic Agents

Phase 3

6

Hypolipidemic Agents

Phase 3

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	A Comparative Study of Pravastatin vs Placebo as Primary Prevention of Severe Subcutaneous Breast Fibrosis in Hyper-radiosensitive Identified Patients With Breast Cancer	Recruiting	NCT04385433	Phase 3	EXPERIMENTAL ARM
2	Improving Theempowerment in Patients With Severe Breast Fibrosis Radio-induced Treated by Pravastatin : Benefit of e-PROs (Electronic " Patient Reported Outcome ") on Breast-related Quality of Life	Recruiting	NCT04356209	Phase 2	Pravastatin
3	The PhysioTouch, A Novel Treatment for Radiation Fibrosis Syndrome in Breast Cancer Patients	Withdrawn	NCT03496909

Search NIH Clinical Center for Fibrosclerosis of Breast

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Genetic Tests for Fibrosclerosis of Breast

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Anatomical Context for Fibrosclerosis of Breast

MalaCards organs/tissues related to Fibrosclerosis of Breast:

⁴⁰

Breast

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Publications for Fibrosclerosis of Breast

Articles related to Fibrosclerosis of Breast:

(show all 28)

#	Title	Authors	PMID	Year
1	Stromal Fibrosis of the Breast: A Spectrum of Benign to Malignant Imaging Appearances. ⁶¹	Nassar L...Berjawi G	30886748	2019
2	Underdiagnosed and disfiguring - Radiation-induced morphea following breast cancer treatment. ⁶¹	Friedman O...Hafner A	29635112	2018
3	XRCC1 Polymorphism Associated With Late Toxicity After Radiation Therapy in Breast Cancer Patients. ⁶¹	Seibold P...Chang-Claude J	26072091	2015
4	Stromal fibrosis of the breast: outcome analysis. ⁶¹	Shin S...Ko EY	23963149	2014
5	Focal fibrosis of the breast diagnosed by core needle biopsy under imaging guidance. ⁶¹	Wiratkapun C...Lertsittichai P	23539939	2013
6	Fibrotic lesions of the breast: radiological findings and core-neddle biopsy results. ⁶¹	Taskin F...Karaman C	21071162	2011
7	MRI features of stromal fibrosis of the breast with histopathologic correlation. ⁶¹	Lee SJ...Khan S	21862821	2011
8	Prospective study validating inter- and intraobserver variability of tissue compliance meter in breast tissue of healthy volunteers: potential implications for patients with radiation-induced fibrosis of the breast. ⁶¹	Wernicke AG...Chao KS	20395064	2011
9	Quantitative assessment of radiation-induced fibrosis of the breast with tissue compliance meter, palpation, and radiological imaging: preliminary results. ⁶¹	Wernicke AG...Nori D	19824999	2009
10	Neoadjuvant interstitial high-dose-rate (HDR) brachytherapy combined with systemic chemotherapy in patients with breast cancer. ⁶¹	Roddiger SJ...Zamboglou N	16404517	2006
11	Focal fibrosis of the breast diagnosed by a sonographically guided core biopsy of nonpalpable lesions: imaging findings and clinical relevance. ⁶¹	You JK...Yang WI	16179621	2005
12	Stromal fibrosis of the breast. ⁶¹	Sklair-Levy M...Shumak R	11517049	2001
13	[Radiotherapy of locally advanced breast carcinoma in elderly female patients]. ⁶¹	Mladenovic J...Jelic Lj	11255686	2000
14	Focal fibrosis of the breast: imaging characteristics and histopathologic correlation. ⁶¹	Revelon G...Brem RF	10887257	2000
15	Focal fibrosis of the breast in diabetes. ⁶¹	Hall FM	10701645	2000
16	TGF-beta1 levels in pre-treatment plasma identify breast cancer patients at risk of developing post-radiotherapy fibrosis. ⁶¹	Li C...Kumar S	10096248	1999
17	Lymphocytic mastitis and fibrosis of the breast in long-standing insulin-dependent diabetics. A histopathologic study on diabetic mastopathy and report of ten cases. ⁶¹	Hunfeld KP...Bassler R	9269908	1997
18	"Diabetic mastopathy" in the male breast--a special type of gynecomastia. A comparative study of lymphocytic mastitis and gynecomastia. ⁶¹	Hunfeld KP...Kronsbein H	9198105	1997
19	Tissue eosinophilia and eosinophil degranulation in syndromes associated with fibrosis. ⁶¹	Noguchi H...Gleich GJ	1739138	1992
20	Fibrosis of the breast with papillomatosis and calcifications. ⁶¹	Van Laere M...Bosmans J	2277021	1990
21	Inflammatory carcinoma of the breast: treatment results on 107 patients. ⁶¹	Fields JN...Bartlett N	2753755	1989
22	[Side effects and complications in breast-saving therapy of breast cancer]. ⁶¹	Engel K...Schmidt W	2737432	1989
23	Correlation between non-toxic goitre and benign mastopathia. The result of a survey in 477 middle-aged women. ⁶¹	Borup Christensen S	3604754	1987
24	[Fibrosis of the breast. A study of 50 women with a control group]. ⁶¹	Wenderlein JM...Eisentraut R	6645908	1983
25	Irradiation with external beam and interstitial radioactive implant as primary treatment for early carcinoma of the breast. ⁶¹	Martinez A...Goffinet D	6781081	1981
26	Relation between time-dose and local control of operable breast cancer treated by tumorectomy and radiotherapy or by radical radiotherapy alone. ⁶¹	Bataini JP...Calle R	101301	1978
27	[Dysplasia of the glandular epithelium in male patients with fibrosis of the breast and their relations to carcinoma]. ⁶¹	Kruckemeyer K	4884531	1968
28	Fibrosis of the breast. ⁶¹	VASSAR PS...CULLING CF	13616820	1959

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Genes for Fibrosclerosis of Breast

Genes related to Fibrosclerosis of Breast (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	XRCC1	X-Ray Repair Cross Complementing 1	Protein Coding	5.31	DISEASES inferred ¹⁵
2	DGKA	Diacylglycerol Kinase Alpha	Protein Coding	4.87	DISEASES inferred ¹⁵
3	ENG	Endoglin	Protein Coding	4.55	DISEASES inferred ¹⁵
4	CCN2	Cellular Communication Network Factor 2	Protein Coding	4.53	DISEASES inferred ¹⁵
5	RASGRP1	RAS Guanyl Releasing Protein 1	Protein Coding	4.46	DISEASES inferred ¹⁵
6	LIG4	DNA Ligase 4	Protein Coding	4.3	DISEASES inferred ¹⁵

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Variations for Fibrosclerosis of Breast

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Expression for Fibrosclerosis of Breast

Search GEO for disease gene expression data for Fibrosclerosis of Breast.

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Pathways for Fibrosclerosis of Breast

Pathways related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Effects of PIP2 hydrolysis ⁶⁵ Show member pathways Arachidonate production from DAG ⁶⁵	10.46	RASGRP1 DGKA
2	Hypothesized Pathways in Pathogenesis of Cardiovascular Disease ¹	10.02	ENG CCN2

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GO Terms for Fibrosclerosis of Breast

Biological processes related to Fibrosclerosis of Breast according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intracellular signal transduction	GO:0035556	9.58	RASGRP1 DGKA CCN2
2	positive regulation of JNK cascade	GO:0046330	9.46	RASGRP1 CCN2
3	double-strand break repair via nonhomologous end joining	GO:0006303	9.43	XRCC1 LIG4
4	DNA biosynthetic process	GO:0071897	9.37	LIG4 CCN2
5	positive regulation of protein phosphorylation	GO:0001934	9.33	RASGRP1 ENG CCN2
6	positive regulation of collagen biosynthetic process	GO:0032967	9.32	ENG CCN2
7	nucleotide-excision repair, DNA gap filling	GO:0006297	9.26	XRCC1 LIG4
8	single strand break repair	GO:0000012	8.96	XRCC1 LIG4
9	extracellular matrix constituent secretion	GO:0070278	8.62	ENG CCN2

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Sources for Fibrosclerosis of Breast

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 05-Apr-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia