MCID: FBR009
MIFTS: 48

Fibrous Dysplasia

Categories: Bone diseases, Rare diseases

Aliases & Classifications for Fibrous Dysplasia

MalaCards integrated aliases for Fibrous Dysplasia:

Name: Fibrous Dysplasia 12 73 20 54 15 70 32
Fibrous Dysplasia of Bone 20

Classifications:



External Ids:

Disease Ontology 12 DOID:0080031
ICD10 32 M85.0
UMLS 70 C0259779

Summaries for Fibrous Dysplasia

GARD : 20 Fibrous dysplasia is a skeletal disorder that is characterized by the replacement of normal bone with fibrous bone tissue. It may involve one bone ( monostotic ) or multiple bones ( polyostotic ). Fibrous dysplasia can affect any bone in the body. The most common sites are the bones in the skull and face, the long bones in the arms and legs, the pelvis, and the ribs. Though many people with this disorder do not have any symptoms, others may have bone pain, abnormally shaped bones (deformities), or an increased risk of fractures (broken bones). The problems a person experiences depend on which bones are affected, and may arise from compression and displacement of adjacent structures to the lesions. For example, the legs can be of different lengths, leading to a limp, the bones of the sinuses can be affected, leading to chronic sinus congestion or headache. This condition can occur alone or as part of a genetic disorder, such as McCune-Albright syndrome. While there is no cure for fibrous dysplasia, the symptoms can be treated. Medications known as bisphosphonates can reduce pain and surgery may be used to treat fractures or to correct misshapen bones.

MalaCards based summary : Fibrous Dysplasia, also known as fibrous dysplasia of bone, is related to fibrous dysplasia/mccune-albright syndrome and osteofibrous dysplasia. An important gene associated with Fibrous Dysplasia is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are ERK Signaling and TGF-Beta Pathway. The drugs Etidronic acid and Risedronate have been mentioned in the context of this disorder. Affiliated tissues include bone, pituitary and bone marrow, and related phenotypes are growth/size/body region and immune system

Disease Ontology : 12 A bone remodeling disease that results in the destruction of normal bone and replacing it with fibrous bone tissue.

Wikipedia : 73 Fibrous dysplasia is a disorder where normal bone and marrow is replaced with fibrous tissue, resulting... more...

Related Diseases for Fibrous Dysplasia

Diseases related to Fibrous Dysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 500)
# Related Disease Score Top Affiliating Genes
1 fibrous dysplasia/mccune-albright syndrome 32.4 PRL GNAS GH1
2 osteofibrous dysplasia 32.2 SPP1 SPARC GNAS BGLAP
3 cherubism 32.0 TNFSF11 SH3BP2 CALCA
4 mccune-albright syndrome 31.8 SST SPARC PRL IGF1 IBSP GNAS
5 aneurysmal bone cysts 31.2 TNFSF11 TNFRSF11A CALCA
6 ossifying fibroma 31.0 GNAS FGFR1 CDC73
7 osteomalacia 30.8 FGF23 CALCA BGLAP
8 mammary paget's disease 30.7 TNFSF11 TNFRSF11A CALCA BGLAP
9 hyperparathyroidism 30.6 TNFSF11 FGF23 CDC73 CALCA BGLAP
10 hypophosphatemia 30.5 SPP1 FGFR1 FGF23 BGLAP
11 gigantism 30.4 PRL GHRH GH1
12 osteonecrosis 30.4 TNFSF11 IGF1 BGLAP
13 secondary hyperparathyroidism 30.3 FGF23 CALCA BGLAP
14 hyperostosis 30.3 SPP1 IGF1 FGF23
15 osteoblastoma 30.3 SPARC FGF23 BGLAP
16 giant cell reparative granuloma 30.3 TNFSF11 TNFRSF11A SH3BP2 CALCA
17 scoliosis 30.2 TNFSF11 TNFRSF11A IGF1 GH1 BGLAP
18 chromophobe adenoma 30.0 PRL GH1
19 hyperthyroidism 30.0 SST PRL IGF1 GNAS GH1 CALCA
20 nevus, epidermal 30.0 GNAS FGFR1 FGF23
21 osteogenic sarcoma 30.0 TP53 TNFSF11 SPP1 SPARC IGF1 IBSP
22 pituitary tumors 29.9 SST PRL IGF1 GNAS GH1
23 partial third-nerve palsy 29.9 PRL IGF1 GH1
24 empty sella syndrome 29.9 PRL IGF1 GH1
25 osteitis fibrosa 29.9 GNAS FGF23 CDC73 CALCA BGLAP
26 paget's disease of bone 29.9 TNFSF11 TNFRSF11A SPARC IBSP CALCA BGLAP
27 acromegaly 29.9 SST PRL IGF1 GNAS GHRH GH1
28 acanthosis nigricans 29.9 PRL IGF1 GH1
29 amenorrhea 29.8 PRL IGF1 BGLAP
30 renal osteodystrophy 29.8 TNFSF11 FGF23 CALCA BGLAP
31 bone resorption disease 29.8 TNFSF11 TNFRSF11A SPP1 IGF1 IBSP FGF23
32 conn's syndrome 29.8 SST PRL IGF1 GNAS GH1 CALCA
33 hypoparathyroidism 29.6 IGF1 GNAS FGF23 CALCA BGLAP
34 osteopetrosis 29.6 TNFSF11 TNFRSF11A CALCA BGLAP
35 pituitary adenoma 29.6 SST PRL IGF1 GNAS GHRH GH1
36 hypophosphatemic rickets, x-linked dominant 29.6 SPP1 IBSP FGFR1 FGF23 BGLAP
37 calcinosis 29.6 SPP1 SPARC GNAS FGF23 CALCA
38 pseudohypoparathyroidism 29.6 PRL IGF1 GNAS CALCA BGLAP
39 parathyroid adenoma 29.5 IGF1 GNAS CDC73 CALCA BGLAP
40 bone disease 29.5 TNFSF11 TNFRSF11A SPP1 SPARC IGF1 IBSP
41 benign giant cell tumor 29.5 TNFSF11 TNFRSF11A FGF23 CALCA BGLAP
42 goiter 29.4 SST PRL IGF1 GNAS CALCA BGLAP
43 connective tissue benign neoplasm 29.4 TP53 TNFSF11 CDC73
44 bone osteosarcoma 29.4 TP53 TNFSF11 SPARC GNAS BGLAP
45 pituitary adenoma, prolactin-secreting 29.4 SST PRL IGF1 GNAS GH1
46 hyperprolactinemia 29.3 SST PRL IGF1 GNAS GHRH GH1
47 neuroendocrine tumor 29.3 SST IGF1 GHRH CALCA
48 brittle bone disorder 29.2 TNFSF11 TNFRSF11A SPP1 SPARC IGF1 IBSP
49 primary hyperparathyroidism 29.2 TNFSF11 PRL IGF1 GHRH FGF23 CDC73
50 hormone producing pituitary cancer 29.1 SST PRL IGF1 GNAS GHRH

Graphical network of the top 20 diseases related to Fibrous Dysplasia:



Diseases related to Fibrous Dysplasia

Symptoms & Phenotypes for Fibrous Dysplasia

MGI Mouse Phenotypes related to Fibrous Dysplasia:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.39 CDC73 FGF23 FGFR1 GHRH GNAS IBSP
2 immune system MP:0005387 10.39 BGLAP CDC73 FGF23 FGFR1 GHRH GNAS
3 homeostasis/metabolism MP:0005376 10.38 BGLAP CDC73 FGF23 FGFR1 GHRH GNAS
4 hematopoietic system MP:0005397 10.37 BGLAP CDC73 FGF23 FGFR1 GHRH GNAS
5 behavior/neurological MP:0005386 10.34 CDC73 FGFR1 GHRH GNAS POSTN PRL
6 endocrine/exocrine gland MP:0005379 10.3 BGLAP CDC73 FGF23 FGFR1 GHRH GNAS
7 craniofacial MP:0005382 10.29 CDC73 FGFR1 GNAS IBSP POSTN SH3BP2
8 integument MP:0010771 10.21 CDC73 FGF23 FGFR1 GNAS IGF1 PRL
9 digestive/alimentary MP:0005381 10.14 CDC73 FGF23 FGFR1 IBSP SH3BP2 SST
10 limbs/digits/tail MP:0005371 10.14 FGF23 FGFR1 GNAS IBSP IGF1 POSTN
11 adipose tissue MP:0005375 10.11 BGLAP CDC73 GHRH GNAS IGF1 SST
12 liver/biliary system MP:0005370 9.97 CDC73 GHRH GNAS PRL SH3BP2 SPP1
13 muscle MP:0005369 9.97 CDC73 FGFR1 GNAS IGF1 POSTN SH3BP2
14 neoplasm MP:0002006 9.96 CDC73 GNAS IGF1 POSTN PRL SPARC
15 reproductive system MP:0005389 9.93 BGLAP CDC73 FGF23 FGFR1 GHRH IGF1
16 respiratory system MP:0005388 9.61 CDC73 FGF23 GNAS IGF1 SH3BP2 SPP1
17 skeleton MP:0005390 9.53 BGLAP CDC73 FGF23 FGFR1 GHRH GNAS

Drugs & Therapeutics for Fibrous Dysplasia

Drugs for Fibrous Dysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 28)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etidronic acid Approved Phase 2, Phase 3 7414-83-7, 2809-21-4 3305
2
Risedronate Approved, Investigational Phase 2, Phase 3 105462-24-6 5245
3 calcium channel blockers Phase 2, Phase 3
4 Calcium, Dietary Phase 2, Phase 3
5
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271
6
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
7
Alendronate Approved Phase 2 121268-17-5, 66376-36-1 2088
8
Testolactone Approved, Investigational Phase 2 968-93-4 13769
9
Fulvestrant Approved, Investigational Phase 2 129453-61-8 104741 17756771
10
Denosumab Approved Phase 2 615258-40-7
11
Rolipram Investigational Phase 1, Phase 2 61413-54-5
12 Diphosphonates Phase 2
13 Aromatase Inhibitors Phase 2
14 Antidepressive Agents Phase 1, Phase 2
15 Phosphodiesterase Inhibitors Phase 1, Phase 2
16 Phosphodiesterase 4 Inhibitors Phase 1, Phase 2
17 Psychotropic Drugs Phase 1, Phase 2
18 Hormones Phase 2
19 Hormone Antagonists Phase 2
20 Antineoplastic Agents, Hormonal Phase 2
21 Estrogens Phase 2
22 Estrogen Receptor Antagonists Phase 2
23 Estrogen Antagonists Phase 2
24
Letrozole Approved, Investigational Phase 1 112809-51-5 3902
25
Histamine Approved, Investigational 51-45-6, 75614-87-8 774
26
Histamine Phosphate 51-74-1 65513
27 Fluorodeoxyglucose F18
28 Radiopharmaceuticals

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of Bone Unknown status NCT00445575 Phase 2, Phase 3 risedronate;placebo;risedronate;placebo
2 A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome Completed NCT00017927 Phase 3 Pegvisomant
3 TREATMENT OF FIBROUS DYSPLASIA OF BONE WITH TOCILIZUMAB AMONG PATIENTS WHO DO NOT RESPOND TO BISPHOSPHONATES. THE TOCIDYS TRIAL. Completed NCT01791842 Phase 2 Tocilizumab;Placebo
4 An Open-label Study Evaluating the Safety and Efficacy of Anastrozole™ (ARIMIDEX) in the Treatment of Precocious Puberty in Girls With McCune-Albright Syndrome Completed NCT00055302 Phase 2 Arimidex 1 mg
5 A Randomized, Placebo-Controlled Trial of Alendronate in the Treatment of Polyostotic Fibrous Dysplasia and the McCune-Albright Syndrome Completed NCT00001728 Phase 2 Fosamax (Alendronate)
6 Testolactone Treatment of Girls With LHRH Analog-Resistant Precocious Puberty Due to Autonomous, Non-Neoplastic Ovarian Estrogen Secretion Completed NCT00001181 Phase 2 Testolactone
7 PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of Mccune-Albright Syndrome Completed NCT02743377 Phase 1, Phase 2 Whole Body PET Baseline with 11C Rolipram;Whole Body PET Blocked with Roflumilast
8 An Open-label, Non-Comparative Trial to Evaluate the Safety, Efficacy and Pharmacokinetics of Faslodex (Fulvestrant) in Girls With Progressive Precocious Puberty Associated With McCune-Albright Syndrome Active, not recruiting NCT00278915 Phase 2 Fulvestrant
9 An Open Label Pilot Study of Denosumab Treatment for Fibrous Dysplasia Enrolling by invitation NCT03571191 Phase 2 Denosumab
10 Effects of the Aromatase Inhibitor Letrozole on Pubertal Progression and Indices of Bone Turnover in Girls With Precocious Puberty and McCune-Albright Syndrome (MAS) Completed NCT00006174 Phase 1 Letrozole
11 Computer Guided Contouring of Craniofacial Fibrous Dysplasia Involving Zygoma: a Case Series Unknown status NCT03852927
12 Studies on Tissues From Patients With Fibrous Dysplasia of Bone/McCune-Albright Syndrome and Other Disorders of Calcified Tissues Completed NCT00001973
13 Evaluation and Treatment to Improve Bone Quality and Prevent Fractures by the Percutaneous Replacement of Diseased Tissue in Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Completed NCT00001851
14 Interest of Serum Periostin Dosage in Patients With Bone Fibrous Dysplasia Completed NCT02868645
15 Histamine Responsiveness in Patients With McCune-Albright Syndrome Completed NCT00318097
16 Screening and Natural History of Patients With Polyostotic Fibrous Dysplasia and the McCune-Albright Syndrome Recruiting NCT00001727
17 Autotaxin in Patients With GNAS/PTH Abnormalities Recruiting NCT04671719
18 Elucidating Mechanisms of Pain in Adolescent and Adult Fibrous Dysplasia Patients Recruiting NCT04125862
19 Fibrous Dysplasia, McCune-Albright Syndrome Patient Registry Recruiting NCT03231644
20 Epigenetic Regulation of Activity and Severity of Fibrous Dysplasia in Bone: mirDYS Study. Recruiting NCT03838991
21 Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome Withdrawn NCT03520153

Search NIH Clinical Center for Fibrous Dysplasia

Genetic Tests for Fibrous Dysplasia

Anatomical Context for Fibrous Dysplasia

MalaCards organs/tissues related to Fibrous Dysplasia:

40
Bone, Pituitary, Bone Marrow, Thyroid, Skin, Breast, Prostate

Publications for Fibrous Dysplasia

Articles related to Fibrous Dysplasia:

(show top 50) (show all 3834)
# Title Authors PMID Year
1
[Abnormal expression of c-myc, p53, p16 protein and GNAS1 gene mutation in fibrous dysplasia]. 54 61
19575869 2009
2
GNAS1 mutations occur more commonly than previously thought in intramuscular myxoma. 54 61
19287459 2009
3
[Fibrous dysplasia of bone in a young male]. 54 61
19627736 2009
4
Melorheostosis and FGF-23: is there a relationship? 54 61
18485783 2008
5
Fibrous dysplasia, phosphate wasting and fibroblast growth factor 23. 54 61
17982392 2007
6
The pathology of fibrous dysplasia and the McCune-Albright syndrome. 61 54
17982387 2007
7
GNAS transcripts in skeletal progenitors: evidence for random asymmetric allelic expression of Gs alpha. 54 61
17566083 2007
8
A sensitive mutation-specific screening technique for GNAS1 mutations in cases of fibrous dysplasia: the first report of a codon 227 mutation in bone. 54 61
17493233 2007
9
Current approach to fibrous dysplasia of bone and McCune-Albright syndrome. 61 54
19308500 2007
10
Ossifying fibroma vs fibrous dysplasia of the jaw: molecular and immunological characterization. 61 54
17334331 2007
11
McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamping method. 54 61
17878646 2007
12
The new bone biology: pathologic, molecular, and clinical correlates. 61 54
17103447 2006
13
Pegvisomant for the treatment of gsp-mediated growth hormone excess in patients with McCune-Albright syndrome. 54 61
16720661 2006
14
Runx2 regulates the expression of GNAS on SaOs-2 cells. 61 54
16442859 2006
15
McCune-Albright syndrome: growth hormone and prolactin hypersecretion. 61 54
16789626 2006
16
Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia. 54 61
16337659 2006
17
Skeletal changes in epidermal nevus syndrome: does focal bone disease harbor clues concerning pathogenesis? 54 61
16222671 2005
18
A highly sensitive polymerase chain reaction method detects activating mutations of the GNAS gene in peripheral blood cells in McCune-Albright syndrome or isolated fibrous dysplasia. 61 54
16264125 2005
19
Fibroblast growth factor 23 and its receptors. 61 54
16076372 2005
20
Fibrous dysplasia. Pathophysiology, evaluation, and treatment. 54 61
16085630 2005
21
Juvenile psammomatoid ossifying fibroma of the neurocranium. Report of four cases. 54 61
16028779 2005
22
FGF23 and disorders of phosphate homeostasis. 61 54
15863037 2005
23
Minireview: GNAS: normal and abnormal functions. 61 54
15331575 2004
24
FGF-23 is elevated by chronic hyperphosphatemia. 54 61
15356053 2004
25
Investigation of the GSalpha gene in the diagnosis of fibrous dysplasia. 54 61
15183415 2004
26
A novel technique based on a PNA hybridization probe and FRET principle for quantification of mutant genotype in fibrous dysplasia/McCune-Albright syndrome. 54 61
15096559 2004
27
Dental characteristics of fibrous dysplasia and McCune-Albright syndrome. 54 61
12973283 2003
28
FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. 54 61
12952917 2003
29
Osteoclastogenesis in fibrous dysplasia of bone: in situ and in vitro analysis of IL-6 expression. 54 61
13678786 2003
30
Osteomalacic and hyperparathyroid changes in fibrous dysplasia of bone: core biopsy studies and clinical correlations. 61 54
12854833 2003
31
Is McCune-Albright syndrome overlooked in subjects with fibrous dysplasia of bone? 54 61
12756386 2003
32
Craniofacial anomalies: Clinical and molecular perspectives. 61 54
12772530 2003
33
Melatonin deficiency and fibrous dysplasia: might a relation exist? 61 54
12376077 2002
34
A novel, complex heterozygous mutation within Gsalpha gene in patient with McCune-Albright syndrome. 54 61
12374458 2002
35
Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting. 54 61
11588148 2001
36
Asymmetry: molecular, biologic, embryopathic, and clinical perspectives. 61 54
11471152 2001
37
Detection of c-fos expression in benign and malignant musculoskeletal lesions. 61 54
11398843 2001
38
Familial craniofacial fibrous dysplasia: absence of linkage to GNAS1 and the gene for cherubism. 54 61
11073546 2000
39
A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to Gsalpha mutation at the Arg201 codon: polymerase chain reaction-restriction fragment length polymorphism analysis of paraffin-embedded tissues. 54 61
11272890 2000
40
Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non-McCune-Albright fibrous dysplasia of bone. 54 61
10646121 2000
41
A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to expressions of c-fos and c-jun products and bone matrix proteins: a clinicopathologic review and immunohistochemical study of c-fos, c-jun, type I collagen, osteonectin, osteopontin, and osteocalcin. 54 61
10667418 1999
42
Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. 61 54
10569470 1999
43
A rare case of polyostotic fibrous dysplasia assessed by bone scintigraphy with Tc-99m methylene diphosphonate (MDP). 61 54
10488486 1999
44
[Fibrous dysplasia. The clinico-therapeutic picture and new data on its etiology. A review of the literature]. 54 61
9578646 1998
45
Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation. 54 61
9403710 1997
46
Primary hyperparathyroidism-associated polyostotic fibrous dysplasia: absence of McCune-Albright syndrome mutations. 61 54
9413810 1997
47
Clinical implications of genetic defects in G proteins. The molecular basis of McCune-Albright syndrome and Albright hereditary osteodystrophy. 61 54
8699958 1996
48
Activating mutations of Gs protein in monostotic fibrous lesions of bone. 54 61
8648511 1996
49
Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia. 54 61
7739708 1995
50
Pain Phenotypes in Rare Musculoskeletal and Neuromuscular Diseases. 61
33581222 2021

Variations for Fibrous Dysplasia

Expression for Fibrous Dysplasia

Search GEO for disease gene expression data for Fibrous Dysplasia.

Pathways for Fibrous Dysplasia

Pathways related to Fibrous Dysplasia according to GeneCards Suite gene sharing:

(show all 29)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.72 TP53 TNFSF11 TNFRSF11A SPP1 IGF1 GNAS
2
Show member pathways
13.45 TP53 PRL IGF1 GNAS GHRH GH1
3
Show member pathways
13.31 TP53 TNFSF11 TNFRSF11A IGF1 GNAS GHRH
4
Show member pathways
13.28 TP53 TNFSF11 TNFRSF11A PRL GH1 FGFR1
5
Show member pathways
13.2 TNFSF11 TNFRSF11A IGF1 GHRH GH1 FGFR1
6
Show member pathways
12.95 IGF1 GNAS GHRH GH1 FGFR1 FGF23
7
Show member pathways
12.9 TP53 SPP1 IGF1 GNAS GHRH GH1
8 12.76 TP53 IGF1 GNAS FGFR1 FGF23
9
Show member pathways
12.75 TP53 SPP1 PRL IGF1 IBSP GNAS
10
Show member pathways
12.67 TP53 TNFSF11 IGF1 FGFR1 FGF23
11
Show member pathways
12.59 IGF1 GHRH GH1 FGFR1 FGF23
12
Show member pathways
12.57 TP53 IGF1 GNAS FGFR1 FGF23
13
Show member pathways
12.55 SST IGF1 GNAS GHRH GH1
14
Show member pathways
12.39 TNFSF11 TNFRSF11A PRL GH1
15
Show member pathways
12.31 IGF1 GHRH GH1 FGFR1 FGF23
16
Show member pathways
12.16 TP53 IGF1 GHRH GH1 FGFR1 FGF23
17 11.84 TP53 SPARC IGF1
18 11.82 SPP1 SPARC IGF1 BGLAP
19 11.79 TNFSF11 GNAS FGFR1 FGF23 BGLAP
20 11.72 TP53 PRL BGLAP
21 11.62 IGF1 GNAS GHRH GH1 FGFR1 FGF23
22 11.61 SPP1 IGF1 GH1 FGFR1
23 11.57 SPP1 IGF1 CALCA
24 11.41 SPP1 FGFR1 FGF23 BGLAP
25 10.94 TNFSF11 SPP1 IBSP GNAS BGLAP
26 10.9 TNFSF11 TNFRSF11A SPP1
27 10.83 TNFSF11 SPP1 IGF1 GNAS GHRH GH1
28 10.75 TNFSF11 TNFRSF11A SPP1 IGF1 CALCA BGLAP
29 10.6 TNFSF11 IBSP FGF23 BGLAP

GO Terms for Fibrous Dysplasia

Cellular components related to Fibrous Dysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.77 TNFSF11 SST SPP1 SPARC PRL POSTN
2 extracellular region GO:0005576 9.5 TNFSF11 SST SPP1 SPARC PRL POSTN
3 vesicle GO:0031982 9.46 SPP1 SPARC IBSP BGLAP

Biological processes related to Fibrous Dysplasia according to GeneCards Suite gene sharing:

(show all 26)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.92 TP53 SST GNAS BGLAP
2 extracellular matrix organization GO:0030198 9.88 SPP1 SPARC POSTN IBSP
3 positive regulation of cell proliferation GO:0008284 9.88 TNFRSF11A PRL IGF1 GHRH FGFR1 FGF23
4 cell-cell signaling GO:0007267 9.86 TNFRSF11A SST GHRH CALCA
5 osteoblast differentiation GO:0001649 9.8 SPP1 IBSP BGLAP
6 wound healing GO:0042060 9.8 SPARC POSTN IGF1
7 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.77 TP53 IGF1 GH1
8 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.76 IGF1 GH1 FGFR1
9 skeletal system development GO:0001501 9.76 IGF1 GNAS FGFR1 BGLAP
10 response to nutrient levels GO:0031667 9.74 PRL GH1 BGLAP
11 positive regulation of MAP kinase activity GO:0043406 9.71 TNFSF11 GH1 FGFR1
12 bone development GO:0060348 9.7 TNFSF11 GNAS BGLAP
13 response to heat GO:0009408 9.69 SST IGF1 CALCA
14 monocyte chemotaxis GO:0002548 9.67 TNFSF11 TNFRSF11A CALCA
15 cellular protein metabolic process GO:0044267 9.65 SPP1 PRL IGF1 FGF23 CALCA
16 regulation of osteoclast differentiation GO:0045670 9.61 TNFSF11 BGLAP
17 cellular response to vitamin D GO:0071305 9.61 FGF23 BGLAP
18 biomineral tissue development GO:0031214 9.61 SPP1 IBSP BGLAP
19 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.6 PRL GH1
20 response to gravity GO:0009629 9.55 SPARC BGLAP
21 TNFSF11-mediated signaling pathway GO:0071847 9.48 TNFSF11 TNFRSF11A
22 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.37 TNFSF11 TNFRSF11A
23 positive regulation of bone resorption GO:0045780 9.33 TNFSF11 TNFRSF11A SPP1
24 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.32 TNFSF11 TNFRSF11A
25 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.13 IGF1 GHRH GH1
26 ossification GO:0001503 9.1 TNFSF11 TNFRSF11A SPP1 SPARC IBSP BGLAP

Molecular functions related to Fibrous Dysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.1 SST PRL IGF1 GHRH GH1 CALCA
2 prolactin receptor binding GO:0005148 8.96 PRL GH1

Sources for Fibrous Dysplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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