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MCID: FBR009
MIFTS: 48

Fibrous Dysplasia

Categories: Bone diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Fibrous Dysplasia

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MalaCards integrated aliases for Fibrous Dysplasia:

Name: Fibrous Dysplasia 12 74 52 54 15 71 32
Fibrous Dysplasia of Bone 52

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Bone diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0080031
ICD10 32 M85.0
UMLS 71 C0259779
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Summaries for Fibrous Dysplasia

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NIH Rare Diseases : 52 Fibrous dysplasia is a skeletal disorder that is characterized by the replacement of normal bone with fibrous bone tissue . It may involve one bone (monostotic ) or multiple bones (polyostotic ). Fibrous dysplasia can affect any bone in the body. The most common sites are the bones in the skull and face, the long bones in the arms and legs, the pelvis, and the ribs. Though many people with this disorder do not have any symptoms, others may have bone pain, abnormally shaped bones (deformities), or an increased risk of fractures (broken bones). The problems a person experiences depend on which bones are affected, and may arise from compression and displacement of adjacent structures to the lesions. For example, the legs can be of different lengths, leading to a limp, the bones of the sinuses can be affected, leading to chronic sinus congestion or headache. This condition can occur alone or as part of a genetic disorder , such as McCune-Albright syndrome . While there is no cure for fibrous dysplasia, the symptoms can be treated. Medications known as bisphosphonates can reduce pain and surgery may be used to treat fractures or to correct misshapen bones.

MalaCards based summary : Fibrous Dysplasia, also known as fibrous dysplasia of bone, is related to fibrous dysplasia/mccune-albright syndrome and osteofibrous dysplasia. An important gene associated with Fibrous Dysplasia is GNAS (GNAS Complex Locus), and among its related pathways/superpathways are ERK Signaling and Akt Signaling. The drugs Risedronate and Etidronic acid have been mentioned in the context of this disorder. Affiliated tissues include bone, skin and pituitary, and related phenotypes are growth/size/body region and immune system

Disease Ontology : 12 A bone remodeling disease that results in the destruction of normal bone and replacing it with fibrous bone tissue.

Wikipedia : 74 Fibrous dysplasia is a disorder where normal bone and marrow is replaced with fibrous tissue, resulting... more...

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Related Diseases for Fibrous Dysplasia

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Diseases related to Fibrous Dysplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 494)
# Related Disease Score Top Affiliating Genes
1 fibrous dysplasia/mccune-albright syndrome 34.2 PRL GNAS GH1
2 osteofibrous dysplasia 33.3 SPP1 SPARC GNAS BGLAP
3 cherubism 32.9 TNFSF11 SH3BP2 CALCA
4 mccune-albright syndrome 32.9 SST SPARC PRL IGF1 IBSP GNAS
5 ossifying fibroma 31.4 SH3BP2 GNAS CDC73
6 aneurysmal bone cysts 31.3 TNFSF11 TNFRSF11A CALCA
7 hypophosphatemia 30.9 SPP1 FGF23 BGLAP
8 osteomalacia 30.7 TNFSF11 FGF23 CALCA BGLAP
9 rickets 30.5 SPP1 IBSP FGF23 CALCA BGLAP
10 osteoblastoma 30.4 SPARC FGF23 BGLAP
11 gigantism 30.4 PRL GHRH GH1
12 mammary paget's disease 30.4 TNFSF11 TNFRSF11B TNFRSF11A CALCA BGLAP
13 giant cell reparative granuloma 30.3 TNFSF11 TNFRSF11A SH3BP2 CALCA
14 chromophobe adenoma 30.2 PRL GH1
15 central precocious puberty 30.2 IGF1 GH1
16 secondary hyperparathyroidism 30.1 TNFRSF11B FGF23 CALCA BGLAP
17 hyperostosis 30.1 TNFRSF11B SPP1 IGF1 FGF23
18 meningioma, familial 30.1 TP53 SST PRL IGF1
19 endosteal hyperostosis, autosomal dominant 30.1 TNFSF11 TNFRSF11B IBSP
20 empty sella syndrome 30.0 PRL IGF1 GH1
21 pituitary tumors 29.9 SST PRL IGF1 GNAS GH1
22 osteitis fibrosa 29.9 GNAS FGF23 CDC73 CALCA BGLAP
23 hyperthyroidism 29.9 SST PRL IGF1 GNAS GH1 CALCA
24 amenorrhea 29.9 PRL IGF1 BGLAP
25 hyperparathyroidism 29.9 TNFSF11 TNFRSF11B IGF1 FGF23 CDC73 CALCA
26 hypoparathyroidism 29.7 IGF1 GNAS FGF23 CALCA BGLAP
27 paget's disease of bone 29.7 TNFSF11 TNFRSF11B TNFRSF11A IBSP CALCA BGLAP
28 sclerosteosis 29.6 TNFSF11 TNFRSF11B RUNX2 BGLAP
29 calcinosis 29.6 SPP1 SPARC GNAS FGF23 CALCA
30 pseudohypoparathyroidism 29.6 PRL IGF1 GNAS CALCA BGLAP
31 osteonecrosis 29.6 TNFSF11 TNFRSF11B RUNX2 IGF1 BGLAP
32 parathyroid adenoma 29.6 IGF1 GNAS CDC73 CALCA BGLAP
33 renal osteodystrophy 29.5 TNFSF11 TNFRSF11B FGF23 CALCA BGLAP
34 osteoarthritis 29.5 TNFSF11 TNFRSF11B RUNX2 IGF1 BGLAP
35 acromegaly 29.5 SST PRL IGF1 GNAS GHRH GH1
36 pituitary adenoma 29.4 SST PRL IGF1 GNAS GHRH GH1
37 bone osteosarcoma 29.4 TP53 SPARC RUNX2 GNAS BGLAP
38 pituitary adenoma, prolactin-secreting 29.4 SST PRL IGF1 GNAS GH1
39 goiter 29.4 SST PRL IGF1 GNAS CALCA BGLAP
40 insulin-like growth factor i 29.4 PRL IGF1 GHRH GH1 BGLAP
41 primary hyperparathyroidism 29.3 TNFSF11 TNFRSF11B PRL IGF1 FGF23 CDC73
42 scoliosis 29.3 TNFSF11 TNFRSF11B TNFRSF11A RUNX2 IGF1 GH1
43 osteogenic sarcoma 29.2 TP53 TNFSF11 TNFRSF11B SPP1 SPARC RUNX2
44 hyperprolactinemia 29.1 SST PRL IGF1 GNAS GHRH GH1
45 hormone producing pituitary cancer 29.0 SST PRL IGF1 GNAS GHRH
46 carney complex variant 29.0 SST PRL IGF1 GNAS GHRH
47 brittle bone disorder 28.9 TNFSF11 TNFRSF11B SPP1 SPARC RUNX2 IBSP
48 conn's syndrome 28.8 SST PRL IGF1 GNAS GHRH GH1
49 hydrocephalus 28.8 TP53 SST PRL IGF1
50 osteopetrosis 28.8 TNFSF11 TNFRSF11B TNFRSF11A RUNX2 CALCA BGLAP

Graphical network of the top 20 diseases related to Fibrous Dysplasia:



Diseases related to Fibrous Dysplasia
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Symptoms & Phenotypes for Fibrous Dysplasia

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MGI Mouse Phenotypes related to Fibrous Dysplasia:

45 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.43 CDC73 FGF23 GHRH GNAS IBSP IGF1
2 immune system MP:0005387 10.43 BGLAP CDC73 FGF23 GHRH GNAS IBSP
3 hematopoietic system MP:0005397 10.41 BGLAP CDC73 FGF23 GHRH GNAS IBSP
4 homeostasis/metabolism MP:0005376 10.4 BGLAP CDC73 FGF23 GHRH GNAS IGF1
5 craniofacial MP:0005382 10.34 CDC73 GNAS IBSP POSTN RUNX2 SH3BP2
6 cellular MP:0005384 10.31 BGLAP CDC73 GNAS IGF1 POSTN RUNX2
7 endocrine/exocrine gland MP:0005379 10.31 BGLAP CDC73 FGF23 GHRH GNAS IGF1
8 integument MP:0010771 10.23 CDC73 FGF23 GNAS IGF1 PRL RUNX2
9 limbs/digits/tail MP:0005371 10.21 FGF23 GNAS IBSP IGF1 POSTN RUNX2
10 mortality/aging MP:0010768 10.18 CDC73 FGF23 GNAS IGF1 POSTN RUNX2
11 digestive/alimentary MP:0005381 10.15 CDC73 FGF23 IBSP RUNX2 SH3BP2 SST
12 liver/biliary system MP:0005370 10.06 CDC73 GHRH GNAS PRL RUNX2 SH3BP2
13 muscle MP:0005369 9.97 CDC73 GNAS IGF1 POSTN RUNX2 SH3BP2
14 neoplasm MP:0002006 9.96 CDC73 GNAS IGF1 POSTN PRL SPARC
15 reproductive system MP:0005389 9.93 BGLAP CDC73 FGF23 GHRH IGF1 POSTN
16 respiratory system MP:0005388 9.65 CDC73 FGF23 GNAS IGF1 RUNX2 SH3BP2
17 skeleton MP:0005390 9.55 BGLAP CDC73 FGF23 GHRH GNAS IBSP
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Drugs & Therapeutics for Fibrous Dysplasia

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Drugs for Fibrous Dysplasia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Risedronate Approved, Investigational Phase 2, Phase 3 105462-24-6 5245
2
Etidronic acid Approved Phase 2, Phase 3 2809-21-4, 7414-83-7 3305
3
Zoledronic Acid Approved Phase 3 118072-93-8 68740
4 Calcium, Dietary Phase 2, Phase 3
5 calcium channel blockers Phase 2, Phase 3
6 Diphosphonates Phase 3
7 Pharmaceutical Solutions Phase 3
8 Anesthetics Phase 3
9 Analgesics Phase 3
10
Calcium Nutraceutical Phase 2, Phase 3 7440-70-2 271
11
Alendronate Approved Phase 2 66376-36-1, 121268-17-5 2088
12
Testolactone Approved, Investigational Phase 2 968-93-4 13769
13
Anastrozole Approved, Investigational Phase 2 120511-73-1 2187
14
Fulvestrant Approved, Investigational Phase 2 129453-61-8 104741 17756771
15
Denosumab Approved Phase 2 615258-40-7
16 Aromatase Inhibitors Phase 2
17 Hormones Phase 2
18 Hormone Antagonists Phase 2
19 Estrogen Antagonists Phase 2
20 Estrogen Receptor Antagonists Phase 2
21 Estrogens Phase 2
22 Antineoplastic Agents, Hormonal Phase 2
23
Letrozole Approved, Investigational Phase 1 112809-51-5 3902
24
Histamine Approved, Investigational 51-45-6 774
25
Histamine Phosphate 51-74-1 65513
26 Fluorodeoxyglucose F18
27 Radiopharmaceuticals

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Bioactive Glass Granules as Bone Graft Substitute in Filling Material of Bone Defects Completed NCT01304121 Phase 4
2 Effect of Risedronate on Bone Morbidity in Fibrous Dysplasia of Bone Unknown status NCT00445575 Phase 2, Phase 3 risedronate;placebo;risedronate;placebo
3 A Study of the Effects of Pegvisomant on Growth Hormone Excess in McCune-Albright Syndrome Completed NCT00017927 Phase 3 Pegvisomant
4 Non-inferiority Trial of Three Cycles of Zoledronic Acid Versus Percutaneous Thermal Ablation in Osteoid Osteoma Suspended NCT02739555 Phase 3 Acide Zoledronique
5 TREATMENT OF FIBROUS DYSPLASIA OF BONE WITH TOCILIZUMAB AMONG PATIENTS WHO DO NOT RESPOND TO BISPHOSPHONATES. THE TOCIDYS TRIAL. Completed NCT01791842 Phase 2 Tocilizumab;Placebo
6 A Randomized, Placebo-Controlled Trial of Alendronate in the Treatment of Polyostotic Fibrous Dysplasia and the McCune-Albright Syndrome Completed NCT00001728 Phase 2 Fosamax (Alendronate)
7 Testolactone Treatment of Girls With LHRH Analog-Resistant Precocious Puberty Due to Autonomous, Non-Neoplastic Ovarian Estrogen Secretion Completed NCT00001181 Phase 2 Testolactone
8 An Open-label Study Evaluating the Safety and Efficacy of Anastrozoleâ„¢ (ARIMIDEX) in the Treatment of Precocious Puberty in Girls With McCune-Albright Syndrome Completed NCT00055302 Phase 2 Arimidex 1 mg
9 PET Imaging of Phosphodiesterase-4 (PDE4) in Brain and Peripheral Organs of Mccune-Albright Syndrome Completed NCT02743377 Phase 1, Phase 2 PET
10 An Open-label, Non-Comparative Trial to Evaluate the Safety, Efficacy and Pharmacokinetics of Faslodex (Fulvestrant) in Girls With Progressive Precocious Puberty Associated With McCune-Albright Syndrome Active, not recruiting NCT00278915 Phase 2 Fulvestrant
11 An Open Label Pilot Study of Denosumab Treatment for Fibrous Dysplasia Enrolling by invitation NCT03571191 Phase 2 Denosumab
12 Effects of the Aromatase Inhibitor Letrozole on Pubertal Progression and Indices of Bone Turnover in Girls With Precocious Puberty and McCune-Albright Syndrome (MAS) Completed NCT00006174 Phase 1 Letrozole
13 Molecular Genetic Study of Suspected Cases of Osteogenesis Imperfecta Attending Assiut University Children Hospital Unknown status NCT03169192 Zoledronic Acid
14 Interest of Serum Periostin Dosage in Patients With Bone Fibrous Dysplasia Completed NCT02868645
15 Studies on Tissues From Patients With Fibrous Dysplasia of Bone/McCune-Albright Syndrome and Other Disorders of Calcified Tissues Completed NCT00001973
16 The Influence of Bisphosphonates in the Oral Cavity in Children Completed NCT00402064
17 Evaluation and Treatment to Improve Bone Quality and Prevent Fractures by the Percutaneous Replacement of Diseased Tissue in Polyostotic Fibrous Dysplasia and McCune-Albright Syndrome Completed NCT00001851
18 Histamine Responsiveness in Patients With McCune-Albright Syndrome Completed NCT00318097
19 Epigenetic Regulation of Activity and Severity of Fibrous Dysplasia in Bone: mirDYS Study. Recruiting NCT03838991
20 Fibrous Dysplasia, McCune-Albright Syndrome Patient Registry Recruiting NCT03231644
21 Screening and Natural History of Patients With Polyostotic Fibrous Dysplasia and the McCune-Albright Syndrome Recruiting NCT00001727
22 Computer Guided Contouring of Craniofacial Fibrous Dysplasia Involving Zygoma: a Case Series Recruiting NCT03852927
23 Clinical and Scientific Assessment of Pain and Painful Disorders Recruiting NCT02707029
24 Elucidating Mechanisms of Pain in Adolescent and Adult Fibrous Dysplasia Patients Not yet recruiting NCT04125862
25 Characterization of Diabetes Mellitus in Fibrous Dysplasia/McCune-Albright Syndrome Withdrawn NCT03520153

Search NIH Clinical Center for Fibrous Dysplasia

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Genetic Tests for Fibrous Dysplasia

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Anatomical Context for Fibrous Dysplasia

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MalaCards organs/tissues related to Fibrous Dysplasia:

40
Bone, Skin, Pituitary, Bone Marrow, Brain, Thyroid, Breast
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Publications for Fibrous Dysplasia

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Articles related to Fibrous Dysplasia:

(show top 50) (show all 3734)
# Title Authors PMID Year
1
[Abnormal expression of c-myc, p53, p16 protein and GNAS1 gene mutation in fibrous dysplasia]. 61 54
19575869 2009
2
GNAS1 mutations occur more commonly than previously thought in intramuscular myxoma. 61 54
19287459 2009
3
[Fibrous dysplasia of bone in a young male]. 61 54
19627736 2009
4
Melorheostosis and FGF-23: is there a relationship? 61 54
18485783 2008
5
The pathology of fibrous dysplasia and the McCune-Albright syndrome. 54 61
17982387 2007
6
Fibrous dysplasia, phosphate wasting and fibroblast growth factor 23. 61 54
17982392 2007
7
GNAS transcripts in skeletal progenitors: evidence for random asymmetric allelic expression of Gs alpha. 54 61
17566083 2007
8
A sensitive mutation-specific screening technique for GNAS1 mutations in cases of fibrous dysplasia: the first report of a codon 227 mutation in bone. 61 54
17493233 2007
9
Current approach to fibrous dysplasia of bone and McCune-Albright syndrome. 61 54
19308500 2007
10
Ossifying fibroma vs fibrous dysplasia of the jaw: molecular and immunological characterization. 54 61
17334331 2007
11
McCune-Albright syndrome with acromegaly and fibrous dysplasia associated with the GNAS gene mutation identified by sensitive PNA-clamping method. 61 54
17878646 2007
12
The new bone biology: pathologic, molecular, and clinical correlates. 54 61
17103447 2006
13
Pegvisomant for the treatment of gsp-mediated growth hormone excess in patients with McCune-Albright syndrome. 54 61
16720661 2006
14
Runx2 regulates the expression of GNAS on SaOs-2 cells. 54 61
16442859 2006
15
McCune-Albright syndrome: growth hormone and prolactin hypersecretion. 54 61
16789626 2006
16
Expression of FGF23 is correlated with serum phosphate level in isolated fibrous dysplasia. 54 61
16337659 2006
17
Skeletal changes in epidermal nevus syndrome: does focal bone disease harbor clues concerning pathogenesis? 54 61
16222671 2005
18
A highly sensitive polymerase chain reaction method detects activating mutations of the GNAS gene in peripheral blood cells in McCune-Albright syndrome or isolated fibrous dysplasia. 54 61
16264125 2005
19
Fibroblast growth factor 23 and its receptors. 61 54
16076372 2005
20
Fibrous dysplasia. Pathophysiology, evaluation, and treatment. 54 61
16085630 2005
21
Juvenile psammomatoid ossifying fibroma of the neurocranium. Report of four cases. 61 54
16028779 2005
22
FGF23 and disorders of phosphate homeostasis. 54 61
15863037 2005
23
Minireview: GNAS: normal and abnormal functions. 61 54
15331575 2004
24
FGF-23 is elevated by chronic hyperphosphatemia. 61 54
15356053 2004
25
Investigation of the GSalpha gene in the diagnosis of fibrous dysplasia. 54 61
15183415 2004
26
A novel technique based on a PNA hybridization probe and FRET principle for quantification of mutant genotype in fibrous dysplasia/McCune-Albright syndrome. 54 61
15096559 2004
27
Dental characteristics of fibrous dysplasia and McCune-Albright syndrome. 61 54
12973283 2003
28
FGF-23 in fibrous dysplasia of bone and its relationship to renal phosphate wasting. 54 61
12952917 2003
29
Osteoclastogenesis in fibrous dysplasia of bone: in situ and in vitro analysis of IL-6 expression. 54 61
13678786 2003
30
Osteomalacic and hyperparathyroid changes in fibrous dysplasia of bone: core biopsy studies and clinical correlations. 61 54
12854833 2003
31
Is McCune-Albright syndrome overlooked in subjects with fibrous dysplasia of bone? 61 54
12756386 2003
32
Craniofacial anomalies: Clinical and molecular perspectives. 54 61
12772530 2003
33
Melatonin deficiency and fibrous dysplasia: might a relation exist? 61 54
12376077 2002
34
A novel, complex heterozygous mutation within Gsalpha gene in patient with McCune-Albright syndrome. 61 54
12374458 2002
35
Endocrine manifestations of stimulatory G protein alpha-subunit mutations and the role of genomic imprinting. 61 54
11588148 2001
36
Asymmetry: molecular, biologic, embryopathic, and clinical perspectives. 61 54
11471152 2001
37
Detection of c-fos expression in benign and malignant musculoskeletal lesions. 54 61
11398843 2001
38
Familial craniofacial fibrous dysplasia: absence of linkage to GNAS1 and the gene for cherubism. 54 61
11073546 2000
39
A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to Gsalpha mutation at the Arg201 codon: polymerase chain reaction-restriction fragment length polymorphism analysis of paraffin-embedded tissues. 54 61
11272890 2000
40
Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non-McCune-Albright fibrous dysplasia of bone. 54 61
10646121 2000
41
A comparative study of fibrous dysplasia and osteofibrous dysplasia with regard to expressions of c-fos and c-jun products and bone matrix proteins: a clinicopathologic review and immunohistochemical study of c-fos, c-jun, type I collagen, osteonectin, osteopontin, and osteocalcin. 61 54
10667418 1999
42
Expression of osteocalcin and its transcriptional regulators core-binding factor alpha 1 and MSX2 in osteoid-forming tumours. 61 54
10569470 1999
43
A rare case of polyostotic fibrous dysplasia assessed by bone scintigraphy with Tc-99m methylene diphosphonate (MDP). 54 61
10488486 1999
44
[Fibrous dysplasia. The clinico-therapeutic picture and new data on its etiology. A review of the literature]. 61 54
9578646 1998
45
Fibrous dysplasia of bone in the McCune-Albright syndrome: abnormalities in bone formation. 61 54
9403710 1997
46
Primary hyperparathyroidism-associated polyostotic fibrous dysplasia: absence of McCune-Albright syndrome mutations. 61 54
9413810 1997
47
Clinical implications of genetic defects in G proteins. The molecular basis of McCune-Albright syndrome and Albright hereditary osteodystrophy. 61 54
8699958 1996
48
Activating mutations of Gs protein in monostotic fibrous lesions of bone. 54 61
8648511 1996
49
Increased expression of the c-fos proto-oncogene in bone from patients with fibrous dysplasia. 54 61
7739708 1995
50
Lower limb lengthening and deformity correction in polyostotic fibrous dysplasia using external fixation and flexible intramedullary nailing. 61
32256003 2020
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Variations for Fibrous Dysplasia

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Expression for Fibrous Dysplasia

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Search GEO for disease gene expression data for Fibrous Dysplasia.
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Pathways for Fibrous Dysplasia

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Pathways related to Fibrous Dysplasia according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
ERK Signaling 63
Show member pathways
 13.7 TP53 TNFSF11 TNFRSF11A SPP1 IGF1 GNAS
2
Akt Signaling 63
Show member pathways
 13.27 TP53 TNFSF11 TNFRSF11A IGF1 GNAS GHRH
3
Cytokine Signaling in Immune system 65
Show member pathways
 13.24 TP53 TNFSF11 TNFRSF11B TNFRSF11A PRL GH1
4
Phospholipase-C Pathway 63
Show member pathways
 12.93 TP53 SPP1 IGF1 GNAS GHRH GH1
5
PI3K-Akt signaling pathway 36
Show member pathways
 12.84 TP53 SPP1 PRL IGF1 IBSP GNAS
6
Relaxin signaling pathway 36
Show member pathways
 12.55 SST IGF1 GNAS GHRH GH1
7
Prolactin Signaling Pathway 36 1
Show member pathways
 12.36 TNFSF11 TNFRSF11A PRL GH1
8
Immune response IFN alpha/beta signaling pathway 22
Show member pathways
 12.14 TP53 IGF1 GHRH GH1 FGF23
9
Parathyroid hormone synthesis, secretion and action 36
11.79 TNFSF11 RUNX2 GNAS FGF23 BGLAP
10
Mesenchymal Stem Cells and Lineage-specific Markers 64
11.7 SPP1 SPARC RUNX2 IGF1 BGLAP
11
TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions 64
Show member pathways
 11.69 TNFSF11 TNFRSF11B TNFRSF11A
12
Glucocorticoid receptor regulatory network 1
11.68 TP53 PRL BGLAP
13
G-protein signaling_RhoA regulation pathway 22
11.6 IGF1 GNAS GHRH GH1 FGF23
14
Endochondral Ossification 1
11.59 SPP1 RUNX2 IGF1 GH1
15
Lung fibrosis 1
11.54 SPP1 IGF1 CALCA
16
FGF signaling pathway 1
11.41 SPP1 RUNX2 FGF23 BGLAP
17
Interleukin-11 Signaling Pathway 1
11.37 RUNX2 IBSP BGLAP
18
Development_Hedgehog and PTH signaling pathways in bone and cartilage development 22
11.02 TNFSF11 SPP1 RUNX2 IBSP GNAS BGLAP
19
G-protein signaling_Rap2B regulation pathway 22
10.9 TNFSF11 SPP1 IGF1 GNAS GHRH GH1
20
Transcription_Role of VDR in regulation of genes involved in osteoporosis 22
10.88 TNFSF11 TNFRSF11B TNFRSF11A SPP1 RUNX2 IGF1
21
Osteoclast Signaling 1
10.76 TNFSF11 TNFRSF11B TNFRSF11A SPP1
22
Osteoblast Signaling 1
10.7 TNFSF11 TNFRSF11B IBSP FGF23 BGLAP
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GO Terms for Fibrous Dysplasia

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Cellular components related to Fibrous Dysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.83 TNFSF11 TNFRSF11B SST SPP1 SPARC PRL
2 extracellular space GO:0005615 9.47 TNFSF11 TNFRSF11B SST SPP1 SPARC PRL
3 vesicle GO:0031982 9.46 SPP1 SPARC IBSP BGLAP

Biological processes related to Fibrous Dysplasia according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 10.01 TNFRSF11A RUNX2 PRL IGF1 GHRH
2 response to drug GO:0042493 9.92 TP53 TNFRSF11B SST GNAS BGLAP
3 cell-cell signaling GO:0007267 9.9 TNFRSF11A SST GHRH CALCA
4 extracellular matrix organization GO:0030198 9.85 TNFRSF11B SPP1 SPARC POSTN IBSP
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 TP53 TNFSF11 TNFRSF11B TNFRSF11A
6 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.79 TP53 IGF1 GH1
7 osteoblast differentiation GO:0001649 9.78 SPP1 RUNX2 IBSP BGLAP
8 cellular response to growth factor stimulus GO:0071363 9.77 SPARC IBSP BGLAP
9 cellular protein metabolic process GO:0044267 9.77 SPP1 PRL IGF1 FGF23 CALCA
10 response to nutrient levels GO:0031667 9.75 PRL GH1 BGLAP
11 positive regulation of osteoblast differentiation GO:0045669 9.74 RUNX2 IGF1 GNAS
12 monocyte chemotaxis GO:0002548 9.73 TNFSF11 TNFRSF11A CALCA
13 response to heat GO:0009408 9.72 SST IGF1 CALCA
14 biomineral tissue development GO:0031214 9.69 SPP1 IBSP BGLAP
15 regulation of osteoclast differentiation GO:0045670 9.63 TNFSF11 BGLAP
16 cellular response to vitamin D GO:0071305 9.63 FGF23 BGLAP
17 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.62 PRL GH1
18 response to magnesium ion GO:0032026 9.61 TNFRSF11B FGF23
19 response to gravity GO:0009629 9.58 SPARC BGLAP
20 bone development GO:0060348 9.56 TNFSF11 SPARC GNAS BGLAP
21 TNFSF11-mediated signaling pathway GO:0071847 9.54 TNFSF11 TNFRSF11A
22 positive regulation of bone resorption GO:0045780 9.5 TNFSF11 TNFRSF11A SPP1
23 positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling GO:0071848 9.43 TNFSF11 TNFRSF11A
24 positive regulation of fever generation by positive regulation of prostaglandin secretion GO:0071812 9.4 TNFSF11 TNFRSF11A
25 skeletal system development GO:0001501 9.35 TNFRSF11B RUNX2 IGF1 GNAS BGLAP
26 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.33 IGF1 GHRH GH1
27 ossification GO:0001503 9.17 TNFSF11 TNFRSF11A SPP1 SPARC RUNX2 IBSP

Molecular functions related to Fibrous Dysplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.1 SST PRL IGF1 GHRH GH1 CALCA
2 prolactin receptor binding GO:0005148 8.96 PRL GH1
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Sources for Fibrous Dysplasia

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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