MCID: FLM001
MIFTS: 34

Filamentary Keratitis

Categories: Eye diseases

Aliases & Classifications for Filamentary Keratitis

MalaCards integrated aliases for Filamentary Keratitis:

Name: Filamentary Keratitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4664
ICD10 33 H16.12
ICD9CM 35 370.23
SNOMED-CT 68 51286002
UMLS 73 C0155077

Summaries for Filamentary Keratitis

MalaCards based summary : Filamentary Keratitis is related to keratitis, hereditary and strabismus. An important gene associated with Filamentary Keratitis is MUC4 (Mucin 4, Cell Surface Associated), and among its related pathways/superpathways are Keratinization and CLEC7A (Dectin-1) signaling. The drugs Ambroxol and Expectorants have been mentioned in the context of this disorder. Affiliated tissues include eye, lung and skin.

Related Diseases for Filamentary Keratitis

Diseases related to Filamentary Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 80)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 10.3
2 strabismus 10.3
3 adenomyoma 10.2 MUC1 MUC4
4 cystadenoma 10.2 MUC1 MUC4
5 eccrine porocarcinoma 10.2 KRT1 MUC1
6 biliary tract neoplasm 10.2 MUC1 MUC4
7 cystadenocarcinoma 10.2 MUC1 MUC16
8 adenofibroma 10.2 MUC1 MUC16
9 recessive dystrophic epidermolysis bullosa 10.2 FLG KRT1
10 mucinous cystadenocarcinoma 10.2 MUC1 MUC16
11 cap polyposis 10.2 MUC4 MUC5AC
12 breast mucoepidermoid carcinoma 10.1 MUC1 MUC5AC
13 osteofibrous dysplasia 10.1 KRT1 MUC1
14 solid adenocarcinoma with mucin production 10.1 MUC1 MUC5AC
15 nodular hidradenoma 10.1 KRT10 MUC1
16 epidermolytic acanthoma 10.1 KRT1 KRT10
17 acanthoma 10.1 KRT1 KRT10
18 erythroderma, ichthyosiform, congenital reticular 10.1 KRT1 KRT10
19 bile duct cystadenocarcinoma 10.1 MUC1 MUC5AC
20 ichthyosis, cyclic, with epidermolytic hyperkeratosis 10.1 KRT1 KRT10
21 discoid lupus erythematosus 10.1 FLG KRT10
22 papillary adenocarcinoma 10.1 MUC1 MUC16
23 ichthyosis bullosa of siemens 10.1 KRT1 KRT10
24 mucinous ovarian cystadenoma 10.1 MUC1 MUC5AC
25 epithelioid sarcoma 10.1 KRT1 MUC1
26 biliary papillomatosis 10.1 MUC1 MUC5AC
27 striate palmoplantar keratoderma 10.1 KRT1 KRT10
28 colloid carcinoma of the pancreas 10.1 MUC1 MUC5AC
29 stiff-person syndrome 10.1
30 cataract 10.1
31 telangiectasis 10.1
32 complete androgen insensitivity syndrome 10.1 MUC1 MUC5AC
33 gastric cardia carcinoma 10.1 MUC1 MUC5AC
34 autosomal dominant epidermolytic ichthyosis 10.1 KRT1 KRT10
35 pancreatic mucinous cystadenoma 10.1 MUC1 MUC5AC
36 meconium ileus 10.1 MUC1 MUC5AC
37 pseudomyxoma peritonei 10.1 MUC1 MUC5AC
38 adenosquamous carcinoma 10.1 MUC1 MUC4
39 intraneural perineurioma 10.1 KRT10 MUC1
40 gastric tubular adenocarcinoma 10.1 MUC1 MUC5AC
41 atopic keratoconjunctivitis 10.1 MUC16 MUC5AC
42 ichthyosis vulgaris 10.1 FLG KRT10
43 epstein-barr virus-associated gastric carcinoma 10.1 FLG MUC5AC
44 white sponge nevus 1 10.1 KRT1 KRT10
45 bile duct adenocarcinoma 10.1 MUC1 MUC5AC
46 keratoacanthoma 10.1 FLG KRT10
47 pachyonychia congenita 1 10.1 FLG KRT10
48 bile duct mucoepidermoid carcinoma 10.1 MUC1 MUC4 MUC5AC
49 mucoepidermoid carcinoma 10.1 MUC1 MUC4 MUC5AC
50 mucinous tubular and spindle renal cell carcinoma 10.1 KRT10 MUC1 MUC4

Graphical network of the top 20 diseases related to Filamentary Keratitis:



Diseases related to Filamentary Keratitis

Symptoms & Phenotypes for Filamentary Keratitis

Drugs & Therapeutics for Filamentary Keratitis

Drugs for Filamentary Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ambroxol Investigational Phase 1, Phase 2 18683-91-5
2 Expectorants Phase 1, Phase 2,Not Applicable
3 Respiratory System Agents Phase 1, Phase 2,Not Applicable
4
Pseudoephedrine Approved Not Applicable 90-82-4 7028
5
Ephedrine Approved Not Applicable 299-42-3 9294
6
Guaifenesin Approved, Investigational, Vet_approved Not Applicable 93-14-1 3516
7 Anti-Obesity Agents Not Applicable
8 Adrenergic Agonists Not Applicable
9
Chlorpheniramine Not Applicable 113-92-8, 132-22-9 2725
10 Adrenergic Agents Not Applicable
11 Chlorpheniramine, phenylpropanolamine drug combination Not Applicable
12 Sympathomimetics Not Applicable
13 Adrenergic alpha-Agonists Not Applicable
14 Peripheral Nervous System Agents Not Applicable
15 Vasoconstrictor Agents Not Applicable
16 Autonomic Agents Not Applicable
17 Neurotransmitter Agents Not Applicable
18 Appetite Depressants Not Applicable
19 Nasal Decongestants Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2 Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
2 Mucinex® for Treatment of Filamentary Keratitis Completed NCT02859246 Not Applicable Mucinex®

Search NIH Clinical Center for Filamentary Keratitis

Genetic Tests for Filamentary Keratitis

Anatomical Context for Filamentary Keratitis

MalaCards organs/tissues related to Filamentary Keratitis:

41
Eye, Lung, Skin, Kidney, Liver, Breast, Pancreas

Publications for Filamentary Keratitis

Articles related to Filamentary Keratitis:

(show all 37)
# Title Authors Year
1
Treatment and Resolution of Filamentary Keratitis in a Patient with Stiff Person Syndrome. ( 29040122 )
2018
2
Case Report: Post-keratoplasty Filamentary Keratitis Managed with Scleral Lens. ( 30063659 )
2018
3
Filamentary Keratitis as Indication. ( 29034868 )
2017
4
Ocular-muscle surgery for filamentary keratitis that developed in double elevator palsy. ( 29270032 )
2017
5
Investigation of the clinical features in filamentary keratitis in Hangzhou, east of China. ( 27583881 )
2016
6
Treatment of Refractory Filamentary Keratitis With Autologous Serum Tears. ( 26657665 )
2015
7
Botulinum toxin injection for the management of refractory filamentary keratitis. ( 22491914 )
2012
8
Human epidermal growth factor eyedrops for cetuximab-related filamentary keratitis. ( 21690478 )
2011
9
Question: Can you identify this condition? Filamentary keratitis. ( 20631280 )
2010
10
Effect of lacrimal plugs combined with deproteinized calf blood extract eye gel for filamentary keratitis. ( 23243481 )
2010
11
Investigation of the corneal filament in filamentary keratitis. ( 19443713 )
2009
12
A case report and review of filamentary keratitis. ( 15682560 )
2005
13
Filamentary keratitis occurring after strabismus surgery. ( 15088057 )
2004
14
Management of filamentary keratitis associated with aqueous-deficient dry eye. ( 12808401 )
2003
15
Filamentary keratitis improved by blepharoptosis surgery: two cases. ( 14641279 )
2003
16
The beneficial effect of diclofenac sodium in the treatment of filamentary keratitis. ( 11405858 )
2001
17
Diclofenac sodium, 0.1% (Voltaren Ophtha), versus sodium chloride, 5%, in the treatment of filamentary keratitis. ( 10746444 )
2000
18
Filamentary keratitis caused by corneal occlusion in large-angle strabismus. ( 1574277 )
1992
19
Filamentary keratitis--the clinical challenges. ( 1813523 )
1991
20
Filamentary keratitis associated with diphenhydramine hydrochloride (Benadryl). ( 3953733 )
1986
21
Eledoisin--a successful therapeutic concept for filamentary keratitis. ( 3862278 )
1985
22
The histopathology of filamentary keratitis. ( 4026649 )
1985
23
Filamentary keratitis. ( 7072810 )
1982
24
Filamentary keratitis. ( 7105733 )
1982
25
Filamentary keratitis following penetrating keratoplasty. ( 6752802 )
1982
26
Filamentary keratitis and stromal neovascularization associated with brain-stem injury. ( 6158854 )
1980
27
Study of filamentary keratitis by replica technique. ( 380383 )
1979
28
Filamentary keratitis. ( 1064224 )
1975
29
Contact lens induced filamentary keratitis. ( 1200123 )
1975
30
Treatment of filamentary keratitis with the soft contact lens. ( 4759857 )
1973
31
Filamentary keratitis following cataract extraction. ( 5085203 )
1972
32
A modified Schirmer tear test technique. Its uses in aiding the diagnosis of chronic keratoconjuncitivitis sicca (filamentary keratitis) in dogs. ( 5435003 )
1970
33
Hereditary hemorrhagic telangiectasis (Rendu-Osler-Weber disease) with filamentary keratitis. ( 5764691 )
1969
34
Parenchymatous origin of filamentary keratitis; new histopathologic concepts. ( 13339914 )
1956
35
An unusual case of filamentary keratitis. ( 13248308 )
1955
36
Filamentary Keratitis. ( 16693066 )
1935
37
Case of Filamentary Keratitis. ( 19982517 )
1922

Variations for Filamentary Keratitis

Expression for Filamentary Keratitis

Search GEO for disease gene expression data for Filamentary Keratitis.

Pathways for Filamentary Keratitis

GO Terms for Filamentary Keratitis

Cellular components related to Filamentary Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.87 ELANE KRT1 KRT10 MUC1 MUC16 MUC4
2 extracellular region GO:0005576 9.76 ELANE IL17A KRT1 KRT10 MUC1 MUC16
3 intermediate filament GO:0005882 9.58 FLG KRT1 KRT10
4 vesicle GO:0031982 9.54 MUC1 MUC16 MUC4
5 cornified envelope GO:0001533 9.43 FLG KRT1 KRT10
6 extracellular space GO:0005615 9.28 ELANE IL17A KRT1 KRT10 MERTK MUC1
7 Golgi lumen GO:0005796 9.26 MUC1 MUC16 MUC4 MUC5AC

Biological processes related to Filamentary Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.43 FLG KRT1 KRT10
2 protein heterotetramerization GO:0051290 9.4 KRT1 KRT10
3 defense response to fungus GO:0050832 9.37 ELANE IL17A
4 peptide cross-linking GO:0018149 9.33 FLG KRT1 KRT10
5 establishment of skin barrier GO:0061436 9.32 FLG KRT1
6 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 MUC1 MUC16 MUC4 MUC5AC
7 O-glycan processing GO:0016266 8.92 MUC1 MUC16 MUC4 MUC5AC

Molecular functions related to Filamentary Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 FLG KRT1 KRT10
2 structural constituent of epidermis GO:0030280 8.8 FLG KRT1 KRT10

Sources for Filamentary Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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