MCID: FLM001
MIFTS: 33

Filamentary Keratitis

Categories: Eye diseases

Aliases & Classifications for Filamentary Keratitis

MalaCards integrated aliases for Filamentary Keratitis:

Name: Filamentary Keratitis 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:4664
ICD10 33 H16.12
ICD9CM 35 370.23
SNOMED-CT 68 51286002
UMLS 73 C0155077

Summaries for Filamentary Keratitis

MalaCards based summary : Filamentary Keratitis is related to adenomyoma and sarcomatoid mesothelioma. An important gene associated with Filamentary Keratitis is MUC4 (Mucin 4, Cell Surface Associated), and among its related pathways/superpathways are Keratinization and CLEC7A (Dectin-1) signaling. The drugs Ambroxol and Respiratory System Agents have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain.

Related Diseases for Filamentary Keratitis

Diseases related to Filamentary Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 79)
# Related Disease Score Top Affiliating Genes
1 adenomyoma 10.7 MUC1 MUC4
2 sarcomatoid mesothelioma 10.7 MUC1 MUC4
3 breast secretory carcinoma 10.7 MUC1 MUC4
4 biliary tract neoplasm 10.7 MUC1 MUC4
5 eccrine porocarcinoma 10.7 KRT1 MUC1
6 adenofibroma 10.6 MUC1 MUC16
7 cystadenoma 10.6 MUC1 MUC4
8 osteofibrous dysplasia 10.5 KRT1 MUC1
9 benign mesothelioma 10.5 MUC1 MUC16
10 cap polyposis 10.5 MUC4 MUC5AC
11 papillary adenocarcinoma 10.5 MUC1 MUC16
12 adenosquamous carcinoma 10.5 MUC1 MUC4
13 breast mucoepidermoid carcinoma 10.5 MUC1 MUC5AC
14 nodular hidradenoma 10.5 KRT10 MUC1
15 epidermolytic acanthoma 10.5 KRT1 KRT10
16 bile duct cystadenocarcinoma 10.5 MUC1 MUC5AC
17 epithelioid sarcoma 10.5 KRT1 MUC1
18 erythroderma, ichthyosiform, congenital reticular 10.5 KRT1 KRT10
19 discoid lupus erythematosus 10.5 FLG KRT10
20 acanthoma 10.5 KRT1 KRT10
21 ichthyosis, cyclic, with epidermolytic hyperkeratosis 10.4 KRT1 KRT10
22 ichthyosis, x-linked 10.4 FLG KRT10
23 mucinous ovarian cystadenoma 10.4 MUC1 MUC5AC
24 biliary papillomatosis 10.4 MUC1 MUC5AC
25 colloid carcinoma of the pancreas 10.4 MUC1 MUC5AC
26 striate palmoplantar keratoderma 10.4 KRT1 KRT10
27 complete androgen insensitivity syndrome 10.4 MUC1 MUC5AC
28 meconium ileus 10.4 MUC1 MUC5AC
29 pancreatic mucinous cystadenoma 10.4 MUC1 MUC5AC
30 atopic keratoconjunctivitis 10.4 MUC16 MUC5AC
31 pseudomyxoma peritonei 10.4 MUC1 MUC5AC
32 intraneural perineurioma 10.4 KRT10 MUC1
33 gastric tubular adenocarcinoma 10.4 MUC1 MUC5AC
34 epstein-barr virus-associated gastric carcinoma 10.3 FLG MUC5AC
35 bile duct adenocarcinoma 10.3 MUC1 MUC5AC
36 pachyonychia congenita 1 10.3 FLG KRT10
37 small intestinal adenocarcinoma 10.3 MUC1 MUC5AC
38 keratoacanthoma 10.3 FLG KRT10
39 white sponge nevus 1 10.3 KRT1 KRT10
40 polycystic liver disease 1 with or without kidney cysts 10.2 MUC1 MUC16
41 bile duct mucoepidermoid carcinoma 10.2 MUC1 MUC4 MUC5AC
42 chronic ethmoiditis 10.2 MUC1 MUC4 MUC5AC
43 mucinous tubular and spindle renal cell carcinoma 10.2 KRT10 MUC1 MUC4
44 ethmoid sinusitis 10.2 MUC1 MUC4 MUC5AC
45 limbal stem cell deficiency 10.2 MUC1 MUC4 MUC5AC
46 dry eye syndrome 10.2 MUC1 MUC4 MUC5AC
47 mucoepidermoid carcinoma 10.2 MUC1 MUC4 MUC5AC
48 intrahepatic cholangiocarcinoma 10.2 MUC1 MUC4 MUC5AC
49 strabismus 10.1
50 ichthyosis vulgaris 10.1 FLG KRT1 KRT10

Graphical network of the top 20 diseases related to Filamentary Keratitis:



Diseases related to Filamentary Keratitis

Symptoms & Phenotypes for Filamentary Keratitis

Drugs & Therapeutics for Filamentary Keratitis

Drugs for Filamentary Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ambroxol Approved, Investigational Phase 1, Phase 2 18683-91-5
2 Respiratory System Agents Phase 1, Phase 2,Not Applicable
3 Expectorants Phase 1, Phase 2,Not Applicable
4
Ephedrine Approved Not Applicable 299-42-3 9294
5
Pseudoephedrine Approved Not Applicable 90-82-4 7028
6
Guaifenesin Approved, Investigational, Vet_approved Not Applicable 93-14-1 3516
7
Chlorpheniramine Not Applicable 113-92-8, 132-22-9 2725
8 Adrenergic Agents Not Applicable
9 Adrenergic Agonists Not Applicable
10 Adrenergic alpha-Agonists Not Applicable
11 Chlorpheniramine, phenylpropanolamine drug combination Not Applicable
12 Nasal Decongestants Not Applicable
13 Neurotransmitter Agents Not Applicable
14 Vasoconstrictor Agents Not Applicable
15 Peripheral Nervous System Agents Not Applicable
16 Anti-Obesity Agents Not Applicable
17 Autonomic Agents Not Applicable
18 Appetite Depressants Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effects of Oral Mucolytics on Tear Film and Ocular Surface Completed NCT01713179 Phase 1, Phase 2 Ambroxol hydrochloride (Mucopect®, 60 mg, Boehringer Ingelheim)
2 Mucinex® for Treatment of Filamentary Keratitis Recruiting NCT02859246 Not Applicable Mucinex®

Search NIH Clinical Center for Filamentary Keratitis

Genetic Tests for Filamentary Keratitis

Anatomical Context for Filamentary Keratitis

MalaCards organs/tissues related to Filamentary Keratitis:

41
Eye, Testes, Brain

Publications for Filamentary Keratitis

Articles related to Filamentary Keratitis:

(show all 36)
# Title Authors Year
1
Treatment and Resolution of Filamentary Keratitis in a Patient with Stiff Person Syndrome. ( 29040122 )
2018
2
Filamentary Keratitis as Indication. ( 29034868 )
2017
3
Ocular-muscle surgery for filamentary keratitis that developed in double elevator palsy. ( 29270032 )
2017
4
Investigation of the clinical features in filamentary keratitis in Hangzhou, east of China. ( 27583881 )
2016
5
Treatment of Refractory Filamentary Keratitis With Autologous Serum Tears. ( 26657665 )
2015
6
Botulinum toxin injection for the management of refractory filamentary keratitis. ( 22491914 )
2012
7
Human epidermal growth factor eyedrops for cetuximab-related filamentary keratitis. ( 21690478 )
2011
8
Question: Can you identify this condition? Filamentary keratitis. ( 20631280 )
2010
9
Effect of lacrimal plugs combined with deproteinized calf blood extract eye gel for filamentary keratitis. ( 23243481 )
2010
10
Investigation of the corneal filament in filamentary keratitis. ( 19443713 )
2009
11
A case report and review of filamentary keratitis. ( 15682560 )
2005
12
Filamentary keratitis occurring after strabismus surgery. ( 15088057 )
2004
13
Management of filamentary keratitis associated with aqueous-deficient dry eye. ( 12808401 )
2003
14
Filamentary keratitis improved by blepharoptosis surgery: two cases. ( 14641279 )
2003
15
The beneficial effect of diclofenac sodium in the treatment of filamentary keratitis. ( 11405858 )
2001
16
Diclofenac sodium, 0.1% (Voltaren Ophtha), versus sodium chloride, 5%, in the treatment of filamentary keratitis. ( 10746444 )
2000
17
Filamentary keratitis caused by corneal occlusion in large-angle strabismus. ( 1574277 )
1992
18
Filamentary keratitis--the clinical challenges. ( 1813523 )
1991
19
Filamentary keratitis associated with diphenhydramine hydrochloride (Benadryl). ( 3953733 )
1986
20
Eledoisin--a successful therapeutic concept for filamentary keratitis. ( 3862278 )
1985
21
The histopathology of filamentary keratitis. ( 4026649 )
1985
22
Filamentary keratitis. ( 7072810 )
1982
23
Filamentary keratitis. ( 7105733 )
1982
24
Filamentary keratitis following penetrating keratoplasty. ( 6752802 )
1982
25
Filamentary keratitis and stromal neovascularization associated with brain-stem injury. ( 6158854 )
1980
26
Study of filamentary keratitis by replica technique. ( 380383 )
1979
27
Filamentary keratitis. ( 1064224 )
1975
28
Contact lens induced filamentary keratitis. ( 1200123 )
1975
29
Treatment of filamentary keratitis with the soft contact lens. ( 4759857 )
1973
30
Filamentary keratitis following cataract extraction. ( 5085203 )
1972
31
A modified Schirmer tear test technique. Its uses in aiding the diagnosis of chronic keratoconjuncitivitis sicca (filamentary keratitis) in dogs. ( 5435003 )
1970
32
Hereditary hemorrhagic telangiectasis (Rendu-Osler-Weber disease) with filamentary keratitis. ( 5764691 )
1969
33
Parenchymatous origin of filamentary keratitis; new histopathologic concepts. ( 13339914 )
1956
34
An unusual case of filamentary keratitis. ( 13248308 )
1955
35
Filamentary Keratitis. ( 16693066 )
1935
36
Case of Filamentary Keratitis. ( 19982517 )
1922

Variations for Filamentary Keratitis

Expression for Filamentary Keratitis

Search GEO for disease gene expression data for Filamentary Keratitis.

Pathways for Filamentary Keratitis

GO Terms for Filamentary Keratitis

Cellular components related to Filamentary Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.87 ELANE KRT1 KRT10 MUC1 MUC16 MUC4
2 extracellular region GO:0005576 9.8 ELANE IL17A KRT1 MUC1 MUC16 MUC4
3 intermediate filament GO:0005882 9.58 FLG KRT1 KRT10
4 vesicle GO:0031982 9.54 MUC1 MUC16 MUC4
5 cornified envelope GO:0001533 9.33 FLG KRT1 KRT10
6 extracellular space GO:0005615 9.28 ELANE IL17A KRT1 KRT10 MERTK MUC1
7 Golgi lumen GO:0005796 9.26 MUC1 MUC16 MUC4 MUC5AC

Biological processes related to Filamentary Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.43 FLG KRT1 KRT10
2 peptide cross-linking GO:0018149 9.33 FLG KRT1 KRT10
3 defense response to fungus GO:0050832 9.32 ELANE IL17A
4 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 MUC1 MUC16 MUC4 MUC5AC
5 O-glycan processing GO:0016266 8.92 MUC1 MUC16 MUC4 MUC5AC

Molecular functions related to Filamentary Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 9.13 FLG KRT1 KRT10
2 structural constituent of epidermis GO:0030280 8.8 FLG KRT1 KRT10

Sources for Filamentary Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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