MCID: FLM001
MIFTS: 28

Filamentary Keratitis

Categories: Neuronal diseases

Aliases & Classifications for Filamentary Keratitis

MalaCards integrated aliases for Filamentary Keratitis:

Name: Filamentary Keratitis 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:4664
ICD9CM 34 370.23
SNOMED-CT 67 51286002
ICD10 32 H16.12
UMLS 70 C0155077

Summaries for Filamentary Keratitis

MalaCards based summary : Filamentary Keratitis is related to keratoconjunctivitis and keratoconjunctivitis sicca. An important gene associated with Filamentary Keratitis is MUC4 (Mucin 4, Cell Surface Associated), and among its related pathways/superpathways are CLEC7A (Dectin-1) signaling and Keratinization. The drugs Guaifenesin and Phenylpropanolamine have been mentioned in the context of this disorder. Affiliated tissues include eye and brain.

Related Diseases for Filamentary Keratitis

Diseases related to Filamentary Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 104)
# Related Disease Score Top Affiliating Genes
1 keratoconjunctivitis 30.4 MUC5AC MUC16
2 keratoconjunctivitis sicca 29.6 MUC5AC LACRT BPIFA2
3 dry eye syndrome 29.5 MUC5AC MUC4 MUC1 LCN1 LACRT
4 blepharitis 29.0 MUC5AC MUC4 MUC16 LCN1 LACRT
5 keratitis, hereditary 10.8
6 strabismus 10.3
7 ptosis 10.3
8 mechanical strabismus 10.3
9 lung sarcomatoid carcinoma 10.3 MUC4 MUC1
10 mammary analogue secretory carcinoma 10.3 MUC4 MUC1
11 mucinous tubular and spindle renal cell carcinoma 10.2 MUC4 MUC1
12 adenomyoma 10.2 MUC4 MUC1
13 sarcomatoid mesothelioma 10.2 MUC4 MUC1
14 leukoplakia 10.2 KRT1 FLG
15 eccrine porocarcinoma 10.2 MUC1 KRT1
16 osteofibrous dysplasia 10.2 MUC1 KRT1
17 ifap syndrome 2 10.2
18 keratoconus 10.2
19 cataract 10.2
20 cap polyposis 10.2 MUC5AC MUC4
21 cystadenofibroma 10.2 MUC16 MUC1
22 adenofibroma 10.2 MUC16 MUC1
23 pericardial mesothelioma 10.2 MUC16 MUC1
24 epidermolysis bullosa dystrophica 10.2 KRT1 FLG
25 tn polyagglutination syndrome 10.2 MUC16 MUC1
26 colloid carcinoma of the pancreas 10.2 MUC5AC MUC1
27 pancreatic signet ring cell adenocarcinoma 10.2 MUC5AC MUC1
28 signet ring cell adenocarcinoma 10.2 MUC5AC MUC1
29 intrahepatic biliary papillomatosis 10.2 MUC5AC MUC1
30 biliary papillomatosis 10.1 MUC5AC MUC1
31 urinary bladder villous adenoma 10.1 MUC5AC MUC1
32 villous adenoma 10.1 MUC5AC MUC1
33 mucinous intrahepatic cholangiocarcinoma 10.1 MUC5AC MUC1
34 ichthyosis, congenital, autosomal recessive 4b 10.1 KRT1 FLG
35 bile duct cystadenocarcinoma 10.1 MUC5AC MUC1
36 glandular cystitis 10.1 MUC5AC MUC1
37 pancreatic mucinous cystadenoma 10.1 MUC5AC MUC1
38 biliary tract benign neoplasm 10.1 MUC5AC MUC1
39 mucinous cystadenocarcinoma 10.1 MUC16 MUC1
40 malignant exocrine pancreas neoplasm 10.1 MUC5AC MUC1
41 solid adenocarcinoma with mucin production 10.1 MUC5AC MUC1
42 epithelioid sarcoma 10.1 MUC1 KRT1
43 acute cholangitis 10.1 MUC5AC MUC1
44 appendix disease 10.1 MUC5AC MUC1
45 polycystic liver disease 1 with or without kidney cysts 10.1 MUC16 MUC1
46 ichthyosis vulgaris 10.1 KRT1 FLG
47 appendix cancer 10.1 MUC5AC MUC1
48 complete androgen insensitivity syndrome 10.1 MUC5AC MUC1
49 androgen insensitivity syndrome 10.1 MUC5AC MUC1
50 duodenum cancer 10.1 MUC5AC MUC1

Graphical network of the top 20 diseases related to Filamentary Keratitis:



Diseases related to Filamentary Keratitis

Symptoms & Phenotypes for Filamentary Keratitis

Drugs & Therapeutics for Filamentary Keratitis

Drugs for Filamentary Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Guaifenesin Approved, Investigational, Vet_approved 93-14-1 3516
2
Phenylpropanolamine Approved, Vet_approved, Withdrawn 14838-15-4 26934
3 Respiratory System Agents
4 Chlorpheniramine, phenylpropanolamine drug combination
5 Expectorants

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Mucinex® for Treatment of Filamentary Keratitis Completed NCT02859246 Mucinex®

Search NIH Clinical Center for Filamentary Keratitis

Genetic Tests for Filamentary Keratitis

Anatomical Context for Filamentary Keratitis

MalaCards organs/tissues related to Filamentary Keratitis:

40
Eye, Brain

Publications for Filamentary Keratitis

Articles related to Filamentary Keratitis:

(show top 50) (show all 84)
# Title Authors PMID Year
1
Review on the Use of Topical Ocular Hypertonic Saline in Corneal Edema. 61
33470681 2021
2
Prevalence of Persistent Corneal Epithelial Defects in Chronic Ocular Graft-Versus-Host Disease. 61
32717268 2020
3
Clinical Manifestation and Risk Factors Associated With Remission in Patients With Filamentary Keratitis. 61
32574776 2020
4
Epidemiology of pseudomembranous conjunctivitis in a tertiary hospital: A 2-year retrospective study. 61
32907398 2020
5
Effect of epidermal growth factor ointment on persistent epithelial defects of the cornea. 61
32295556 2020
6
Oral guaifenesin for treatment of filamentary keratitis: A pilot study. 61
30946892 2019
7
Case Report: Post-keratoplasty Filamentary Keratitis Managed with Scleral Lens. 61
30063659 2018
8
Treatment and Resolution of Filamentary Keratitis in a Patient with Stiff Person Syndrome. 61
29040122 2018
9
Treatment outcomes in the DRy Eye Amniotic Membrane (DREAM) study. 61
29670328 2018
10
Manifestation of Clinical Categories of Ocular Graft-versus-Host Disease. 61
30159166 2018
11
Treatment of Refractory Filamentary Keratitis With Autologous Serum Tears. 61
26657665 2017
12
Filamentary Keratitis as Indication. 61
29034868 2017
13
TFOS DEWS II pathophysiology report. 61
28736340 2017
14
Comparison of bandage contact lens removal on the fourth versus seventh postoperative day after photorefractive keratectomy: A randomized clinical trial. 61
28626819 2017
15
Ocular-muscle surgery for filamentary keratitis that developed in double elevator palsy. 61
29270032 2017
16
Investigation of the clinical features in filamentary keratitis in Hangzhou, east of China. 61
27583881 2016
17
Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: results of a phase I trial. 61
26825853 2016
18
Two Patients with Dry Eye Disease Followed Up Using an Expression Assay of Ocular Surface Mucin. 61
27194990 2016
19
Use of Prosthetic Replacement of the Ocular Surface Ecosystem Scleral Lenses in Patients with Ocular Chronic Graft-versus-Host Disease. 61
26234721 2015
20
Outcomes of phacoemulsification in patients with chronic ocular graft-versus-host disease. 61
25619668 2015
21
Ocular manifestations of graft-versus-host disease: 10 years' experience. 61
26170614 2015
22
Ocular manifestations of graft-versus-host disease. 61
24227989 2013
23
Ocular surface complications after trabeculectomy: incidence, risk factors, time course and prognosis. 61
23774034 2013
24
Development of methicillin-resistant Staphylococcus aureus keratitis in a dry eye patient with a therapeutic contact lens. 61
22543732 2012
25
Botulinum toxin injection for the management of refractory filamentary keratitis. 61
22491914 2012
26
[Eyelid surgery for refractory filamentary keratitis]. 61
21882586 2011
27
Human epidermal growth factor eyedrops for cetuximab-related filamentary keratitis. 61
21690478 2011
28
Interleukin-17 in various ocular surface inflammatory diseases. 61
21738349 2011
29
Donor site complications in autolimbal and living-related allolimbal transplantation. 61
21458075 2011
30
Effect of lacrimal plugs combined with deproteinized calf blood extract eye gel for filamentary keratitis. 61
23243481 2010
31
Delayed adjustable sutures: a multicentred clinical review. 61
20576786 2010
32
Question: Can you identify this condition? Filamentary keratitis. 61
20631280 2010
33
Deep anterior lamellar keratoplasty in patients with keratoconus: big-bubble technique. 61
20023579 2010
34
Investigation of the corneal filament in filamentary keratitis. 61
19443713 2009
35
Deep anterior lamellar keratoplasty using the big-bubble technique in keratoconus. 61
23056667 2009
36
Delayed epithelial ingrowth caused by viral conjunctivitis after LASIK. 61
18729311 2008
37
Ocular mucous membrane pemphigoid: diagnosis and management strategies. 61
18781259 2008
38
Clinical evaluation of succinylated collagen bandage lenses for ophthalmic applications. 61
18437036 2008
39
Subconjunctival bevacizumab for corneal neovascularization. 61
17458556 2007
40
The long-term safety of donor eye for 180 degrees limbal transplantation. 61
17120008 2007
41
[The tear crystallization test in sicca syndrome]. 61
17345805 2006
42
[The study of the therapeutic application of PV contact lens]. 61
17165330 2005
43
A case report and review of filamentary keratitis. 61
15682560 2005
44
Filamentary keratitis occurring after strabismus surgery. 61
15088057 2004
45
Filamentary keratitis improved by blepharoptosis surgery: two cases. 61
14641279 2003
46
Topical cyclosporine A 0.5% as a possible new treatment for superior limbic keratoconjunctivitis. 61
12917176 2003
47
Management of filamentary keratitis associated with aqueous-deficient dry eye. 61
12808401 2003
48
The beneficial effect of diclofenac sodium in the treatment of filamentary keratitis. 61
11405858 2001
49
Ocular features associated with anticardiolipin antibodies: a descriptive study. 61
11292408 2001
50
Diclofenac sodium, 0.1% (Voltaren Ophtha), versus sodium chloride, 5%, in the treatment of filamentary keratitis. 61
10746444 2000

Variations for Filamentary Keratitis

Expression for Filamentary Keratitis

Search GEO for disease gene expression data for Filamentary Keratitis.

Pathways for Filamentary Keratitis

GO Terms for Filamentary Keratitis

Cellular components related to Filamentary Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.8 MUC5AC MUC4 MUC16 MUC1 KRT3 KRT1
2 extracellular region GO:0005576 9.76 MUC5AC MUC4 MUC16 MUC1 LCN1 LACRT
3 intermediate filament GO:0005882 9.54 KRT3 KRT1 FLG
4 vesicle GO:0031982 9.5 MUC4 MUC16 MUC1
5 cornified envelope GO:0001533 9.4 KRT1 FLG
6 Golgi lumen GO:0005796 9.26 MUC5AC MUC4 MUC16 MUC1
7 extracellular space GO:0005615 9.23 MUC5AC MUC4 MUC16 MUC1 LCN1 LACRT

Biological processes related to Filamentary Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retina homeostasis GO:0001895 9.37 LCN1 KRT1
2 cornification GO:0070268 9.33 KRT3 KRT1 FLG
3 peptide cross-linking GO:0018149 9.32 KRT1 FLG
4 establishment of skin barrier GO:0061436 9.26 KRT1 FLG
5 stimulatory C-type lectin receptor signaling pathway GO:0002223 9.26 MUC5AC MUC4 MUC16 MUC1
6 O-glycan processing GO:0016266 8.92 MUC5AC MUC4 MUC16 MUC1

Molecular functions related to Filamentary Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of epidermis GO:0030280 8.62 KRT1 FLG

Sources for Filamentary Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....