Filariasis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: FLR002 MIFTS: 58	Filariasis Categories: Infectious diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Filariasis

MalaCards integrated aliases for Filariasis:

Name: Filariasis ¹² ⁷⁶ ⁵⁵ ⁴⁴ ¹⁵ ⁷³

Disease Due to Superfamily Filarioidea ¹²

Classifications:

MalaCards categories:
Global: Infectious diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Certain infectious and parasitic diseases

Helminthiases

Filariasis

Filariasis due to Brugia malayi

Filariasis due to Brugia timori

Filariasis due to Wuchereria bancrofti

Filariasis, unspecified

External Ids:

Disease Ontology ¹² DOID:1080

ICD10 ³³ B74 B74.9 B74.0 more

ICD9CM ³⁵ 125.9

MeSH ⁴⁴ D005368

NCIt ⁵⁰ C34611

SNOMED-CT ⁶⁸ 50342004

UMLS ⁷³ C0016085

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Summaries for Filariasis

Disease Ontology : ¹² A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily Filarioidea.

MalaCards based summary : Filariasis, also known as disease due to superfamily filarioidea, is related to filarial elephantiasis and onchocerciasis. An important gene associated with Filariasis is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ivermectin and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and t cells, and related phenotypes are immune system and digestive/alimentary

Wikipedia : ⁷⁶ Filariasis is a parasitic disease caused by an infection with roundworms of the Filarioidea type. These... more...

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Related Diseases for Filariasis

Diseases related to Filariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 407)

#	Related Disease	Score	Top Affiliating Genes
1	filarial elephantiasis	33.9	IL10 IL5 TLR2 TLR9
2	onchocerciasis	32.2	CCL5 IL2 IL5
3	endomyocardial fibrosis	30.3	IL10 TNF
4	schistosomiasis	30.0	ALB IFNG IL10 IL2 IL5 TNF
5	lymphangiosarcoma	30.0	FLT4 IL2 TNF
6	parasitic helminthiasis infectious disease	29.8	IL10 IL2 IL5 TLR9 TNF
7	lichen planus	29.6	IFNG TLR9 TNF
8	pericarditis	29.5	IFNG IL6 TNF
9	tetanus	29.5	IFNG IL10 IL2 IL5
10	uveitis	29.5	CTLA4 IFNG IL10 TNF
11	arthritis	29.4	IFNG IL10 IL6 TNF
12	chagas disease	29.2	IFNG IL10 IL2 IL6 TLR2 TLR4
13	leishmaniasis	29.1	IFNG IL10 IL2 IL5 IL6 TLR2
14	hemorrhagic fever	29.1	ALB IFNG IL10 IL6 TNF
15	dengue hemorrhagic fever	29.1	ALB IFNG IL10 IL6 TNF
16	parasitic protozoa infectious disease	28.9	IFNG IL10 IL2 IL6 TLR2 TLR9
17	malaria	28.9	TNF TLR9 TLR4 TLR2 IL6 IL5
18	visceral leishmaniasis	28.8	ALB IFNG IL10 IL2 TLR2 TLR4
19	trypanosomiasis	28.4	TNF TLR9 TLR2 IL6 IL2 IL10
20	rheumatoid arthritis	28.3	CCL5 CTLA4 IFNG IL10 IL2 IL6
21	loiasis	12.1
22	dirofilariasis	11.6
23	lymphedema	11.4
24	elephantiasis	11.4
25	mansonelliasis	11.4
26	podoconiosis	11.3
27	setariasis	11.0
28	dipetalonemiasis	11.0
29	hydrocele	10.4
30	prosthetic joint infection	10.3	TLR2 TLR4
31	necatoriasis	10.3	IL10 IL5
32	pouchitis	10.3	IL10 TLR4
33	eosinophilic fasciitis	10.3	IFNG IL5
34	hyperlucent lung	10.3	IFNG IL10
35	sporotrichosis	10.3	IFNG IL10
36	berylliosis	10.3	IFNG IL2
37	fixed drug eruption	10.3	IFNG IL2
38	periodontitis, chronic	10.2	IL6 TLR2
39	gaucher disease, type ii	10.2	IL10 IL2 IL5
40	bagassosis	10.2	IL5 IL6
41	mycosis fungoides	10.2	CTLA4 IL2 IL5
42	keratitis, hereditary	10.2	TLR2 TLR4 TLR9
43	autoimmune lymphoproliferative syndrome	10.2	CTLA4 IL10 IL2
44	acute transverse myelitis	10.2	IL10 IL6
45	suppurative otitis media	10.2	TLR2 TLR4 TLR9
46	septic arthritis	10.2	TLR2 TLR4 TLR9
47	respiratory allergy	10.2	IL10 IL5 TLR9
48	nasal cavity disease	10.2	IL10 IL5 TLR9
49	extrapulmonary tuberculosis	10.2	IFNG IL10 TLR2
50	ige responsiveness, atopic	10.2	IFNG IL10 IL5

Graphical network of the top 20 diseases related to Filariasis:

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Symptoms & Phenotypes for Filariasis

MGI Mouse Phenotypes related to Filariasis:

⁴⁶ (show all 13)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	10.31	CCL5 CHIT1 CTLA4 FLT4 IFNG IL10
2	digestive/alimentary	MP:0005381	10.29	ALB CTLA4 FLT4 IFNG IL10 IL2
3	hematopoietic system	MP:0005397	10.29	CCL5 CTLA4 IFNG IL10 IL2 IL5
4	homeostasis/metabolism	MP:0005376	10.23	ALB CTLA4 FLT4 IFNG IL10 IL2
5	cardiovascular system	MP:0005385	10.18	CTLA4 FLT4 IFNG IL10 IL2 IL6
6	liver/biliary system	MP:0005370	10.11	ALB CTLA4 FLT4 IFNG IL10 IL2
7	endocrine/exocrine gland	MP:0005379	10.1	ALB CTLA4 IFNG IL10 IL2 IL6
8	mortality/aging	MP:0010768	10.06	ALB CTLA4 FLT4 IFNG IL10 IL2
9	integument	MP:0010771	10.01	CTLA4 FLT4 IFNG IL10 IL6 TLR2
10	muscle	MP:0005369	9.86	ALB FLT4 IFNG IL10 IL6 TLR2
11	neoplasm	MP:0002006	9.81	ALB IFNG IL10 IL2 IL5 IL6
12	reproductive system	MP:0005389	9.61	FLT4 IFNG IL10 IL2 IL5 IL6
13	respiratory system	MP:0005388	9.28	CTLA4 IFNG IL10 IL2 IL5 IL6

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Drugs & Therapeutics for Filariasis

Drugs for Filariasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Ivermectin

Approved, Investigational, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

70288-86-7

6474909

Albendazole

Approved, Vet_approved

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

54965-21-8

2082

Diethylcarbamazine

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

90-89-1

3052

Doxycycline

Approved, Investigational, Vet_approved

Phase 4,Phase 3,Phase 2

564-25-0

54671203

Azithromycin

Approved

Phase 4,Phase 3,Phase 2,Not Applicable

83905-01-5

55185 447043

Praziquantel

Approved, Investigational, Vet_approved

Phase 4,Phase 1,Not Applicable

55268-74-1

4891

Anti-Infective Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Antiprotozoal Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Antiparasitic Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Antimitotic Agents

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Anthelmintics

Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable

Lipoxygenase Inhibitors

Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable

Anti-Bacterial Agents

Phase 4,Phase 3,Phase 2,Not Applicable

Antimalarials

Phase 4,Phase 3,Phase 2

Anticonvulsants

Phase 4

Petrolatum

Approved, Investigational

Phase 3

8009-03-8

Glycerol

Approved, Investigational

Phase 3

56-81-5

753

Disinfectants

Phase 3

Protective Agents

Phase 3

Eusol

Phase 3

Sodium hypochlorite

Phase 3

Vitamins

Phase 3

Milbemycin

Phase 3,Phase 2

Reslizumab

Approved, Investigational

Phase 2

Rifampicin

Approved

Phase 2

13292-46-1

5458213 5381226

Dihydroartemisinin

Experimental, Investigational

Phase 2

71939-50-9

6918483

Piperaquine

Experimental, Investigational

Phase 2

4085-31-8

5079497

Artemisinine

Phase 2

Artemisinins

Phase 2

Anti-Asthmatic Agents

Phase 2

Antibodies, Monoclonal

Phase 2

Antibodies

Phase 2

Respiratory System Agents

Phase 2

Immunoglobulins

Phase 2

Antitubercular Agents

Phase 2

Antibiotics, Antitubercular

Phase 2

Cytochrome P-450 CYP3A Inducers

Phase 2

Nucleic Acid Synthesis Inhibitors

Phase 2

Imatinib Mesylate

Phase 2

220127-57-1

123596

Protein Kinase Inhibitors

Phase 2

Romidepsin

Approved, Investigational

Phase 1

128517-07-7

5352062

Pharmaceutical Solutions

Phase 1

Mebendazole

Approved, Vet_approved

31431-39-7

4030

Piperazine

Approved, Vet_approved

110-85-0

4837

Permethrin

Approved, Investigational

Not Applicable

52645-53-1

40326

Citric Acid

Approved, Nutraceutical, Vet_approved

77-92-9

311

Suramin

Investigational

145-63-1

5361

Citrate

Piperazine citrate

Liver Extracts

Not Applicable

Interventional clinical trials:

(show top 50) (show all 67)

#	Name	Status	NCT ID	Phase	Drugs
1	Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali	Completed	NCT02784743	Phase 4	''albendazole'' and ''ivermectin''
2	Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis	Completed	NCT01593722	Phase 4	Diethylcarbamazine;Ivermectin
3	Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection	Completed	NCT02005653	Phase 4	Diethylcarbamazine;Albendazole;Doxycycline
4	Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy	Completed	NCT03052998	Phase 4	Ivermectin
5	Twice Yearly Treatment for the Control of LF	Recruiting	NCT03036059	Phase 4	400 μg/kg Ivermectin + 400 mg Albendazole
6	Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH)	Recruiting	NCT03014167	Phase 4	Albendazole
7	Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin	Not yet recruiting	NCT03570814	Phase 4	Administration of Albendazole on Day 1;Administration of Ivermectin on Day 1;Administration of Azithromycin on Day 1;Administration of Azithromycin on Day 15
8	Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis	Withdrawn	NCT01903057	Phase 4	azithromycin;ivermectin;albendazole;placebo
9	Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis	Withdrawn	NCT02734186	Phase 4	Praziquantel
10	Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study	Completed	NCT02509481	Phase 2, Phase 3	Ivermectin;Albendazole
11	An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis	Completed	NCT02839772	Phase 3
12	IVM Alone vs ALB + IVM Against Onchocerciasis	Completed	NCT03238131	Phase 3	Ivermectin;Albendazole
13	Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection	Completed	NCT00790998	Phase 3	Moxidectin;Ivermectin
14	A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali	Recruiting	NCT02927496	Phase 3	Doxycycline;Placebo
15	A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka	Recruiting	NCT02929134	Phase 3	Doxycycline;Placebo
16	Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana	Active, not recruiting	NCT02078024	Phase 3	IVM plus ALB;IVM
17	A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India	Not yet recruiting	NCT02929121	Phase 3	Doxycycline;Placebo
18	Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs )	Not yet recruiting	NCT03676140	Phase 3	Albendazole on Day 1;Ivermectin on Day 1;Diethylcarbamazine on day 1;Azithromycin on Day 1;Azithromycin on Day 8
19	Effect of Albendazole Dose on Treatment of Lymphatic Filariasis	Completed	NCT00511004	Phase 2	Albendazole;Diethylcarbamazine
20	Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis	Completed	NCT00340691	Phase 2	Doxycycline
21	Effect of Albendazole Dose on Clearance of Filarial Worms	Completed	NCT00339417	Phase 2	Albendazole;Ivermectin
22	Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa	Completed	NCT01975441	Phase 2	Diethylcarbamazine;Albendazole;Ivermectin
23	Effect of Albendazole Dose on Clearance of Filarial Worms	Completed	NCT00375583	Phase 2	DEC/Albendazole
24	Efficacy and Safety of High-dose Ivermectin for Reducing Malaria Transmission: A Dose Finding Study	Completed	NCT02511353	Phase 2	ivermectin;placebo;dihydroartemisinin-piperaquine
25	Reslizumab to Prevent Post-treatment Eosinophilia in Loiasis	Completed	NCT01111305	Phase 2	Reslizumab;Diethylcarbamazine
26	Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection	Completed	NCT00300768	Phase 2	2 mg moxidectin;ivermectin 150 mcg/kg;4 mg moxidectin;8 mg moxidectin
27	Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness	Completed	NCT00127504	Phase 2	Rifampin;Azithromycin
28	Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana	Completed	NCT02281643	Phase 2	Doxycycline
29	PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs )	Not yet recruiting	NCT03664063	Phase 2	Azithromycin;Albendazole;Ivermectin;Diethylcarbamazine
30	Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa	Not yet recruiting	NCT02644525	Phase 2	Imatinib Mesylate;Placebo
31	Pediatric Pharmacokinetics And Safety Study Of Moxidectin	Withdrawn	NCT01035619	Phase 2	moxidectin
32	Relative Bioavailability Study of Emodepside IR-tablets and Solution	Completed	NCT03383523	Phase 1	Emodepside (BAY 44-4400)
33	First in Man Clinical Trial of Emodepside (BAY 44-4400)	Completed	NCT02661178	Phase 1	emodepside (BAY 44-4400);placebo
34	Safety, Tolerability and PK of Multiple-ascending Doses of Emodepside	Recruiting	NCT03383614	Phase 1	LSF emodepside (BAY 44-4400) oral solution (1mg/mL)
35	Pharmacokinetics & Pharmacodynamics of Diethylcarbamazine (DEC)+ Albendazole (ALB) + Ivermectin (IVE)	Active, not recruiting	NCT02845713	Phase 1	Ivermectin, Diethylcarbamazine Albendazole (IDA)
36	Exhaled NO Testing in Filariasis	Completed	NCT01628497
37	Disability and Quality of Life in Patients With Lymphatic Filariasis in Rural Southern India	Completed	NCT01629771
38	Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis	Completed	NCT01905423		Albendazole and diethylcarbamazine
39	Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)	Completed	NCT02032043		Annual versus Semiannual Albendazole plus Ivermectin MDA
40	Research for Elimination of Lymphatic Filariasis (ICIDR)	Completed	NCT00406627
41	Research for Elim of Filariasis	Completed	NCT00145223
42	Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia	Completed	NCT01905436		Annual versus Semiannual Albendazole plus Ivermectin Mass Drug Administration
43	Interaction Between HIV and Lymphatic Filariasis	Completed	NCT00295698	Not Applicable	Diethylcarbamazine
44	Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji	Completed	NCT03177993	Not Applicable	3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA
45	Medical Implications of Coinfection With Malaria and Filariasis Parasites	Completed	NCT00471666
46	Safety of the Co-administration of Three Drugs for Trachoma and Lymphatic Filariasis Elimination	Completed	NCT01586169	Not Applicable	triple co administration at once of the combination of Albendazole + ivermectin + azithromycin
47	Evaluation of Antibacterial Soap for Treatment of Lymphedema in a Filariasis-Endemic Area	Completed	NCT00139100	Not Applicable	antimicrobial agent in soap
48	Prevalence of LF Infection in Districts Not Included in LF Control Activities	Completed	NCT03131401
49	Changes in HIV Viral Load in Patients Undergoing Treatment for Filariasis	Completed	NCT00344279
50	Immune Response Regulation in People Infected Concurrently With Malarial and Filarial Parasites	Completed	NCT00341666

Search NIH Clinical Center for Filariasis

Cochrane evidence based reviews: filariasis

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Genetic Tests for Filariasis

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Anatomical Context for Filariasis

MalaCards organs/tissues related to Filariasis:

⁴¹

Testes, Breast, T Cells, Skin, B Cells, Lung, Eye

Sources

Publications for Filariasis

Articles related to Filariasis:

(show top 50) (show all 1431)

#	Title	Authors	Year
1	A surveillance system for lymphatic filariasis after its elimination in Sri Lanka. ( 30308253 )	Rahman MA...Itoh M	2019
2	Epididymal filariasis a rare presentation of testicular pain. ( 30306047 )	Gordon L...Gordon T	2019
3	Insecticidal efficacy of the essential oil of jambú (Acmella oleracea (L.) R.K. Jansen) cultivated in central Italy against filariasis mosquito vectors, houseflies and moth pests. ( 30149065 )	Benelli G...Maggi F	2019
4	An assessment of mosquito collection techniques for xenomonitoring of anopheline-transmitted Lymphatic Filariasis in Ghana. ( 29898803 )	Opoku M....Reimer L.J.	2018
5	Use of the Litomosoides sigmodontis Infection Model of Filariasis to Study Type 2 Immunity. ( 29956140 )	Fulton A....Taylor M.D.	2018
6	Perceptions, knowledge, attitudes and practices for the prevention and control of lymphatic filariasis in Conakry, Republic of Guinea. ( 29224979 )	Kouassi B.L....Utzinger J.	2018
7	Prevalence of and risk factors for malaria, filariasis, and intestinal parasites as single infections or co-infections in different settlements of Gabon, Central Africa. ( 29378644 )	M'bondoukwAc N.P....Bouyou-Akotet M.K.	2018
8	Bancroftian filariasis associated with male sterility. ( 29330277 )	Panda D.K....Mohapatra D.P.	2018
9	Understanding heterogeneities in mosquito-bite exposure and infection distributions for the elimination of lymphatic filariasis. ( 29386362 )	Irvine M.A....Reimer L.J.	2018
10	Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis. ( 29348597 )	Aljayyoussi G....Ward S.A.	2018
11	Multiplex serology for impact evaluation of bed net distribution on burden of lymphatic filariasis and four species of human malaria in northern Mozambique. ( 29444078 )	Plucinski M.M....Priest J.W.	2018
12	Elimination of lymphatic filariasis as a public health problem from the Cook Islands. ( 29785168 )	Ave C....Ottesen E.	2018
13	Prevalence of Neglected Tropical Diseases (Leishmaniasis and Lymphatic Filariasis) and Malaria Among a Migrant Labour Settlement in Kerala, India. ( 29860672 )	George S....Nair P.	2018
14	Elucidation of immunological response and its regulatory network by P-TUFT-ALT-2: a promising fusion protein vaccine for human lymphatic filariasis. ( 29892388 )	Paul R....Kaliraj P.	2018
15	Assessing knowledge about lymphatic filariasis and the implementation of mass drug administration amongst drug deliverers in three districts/cities of Indonesia. ( 29801511 )	Titaley C.R....Krentel A.	2018
16	Prospects of developing a prophylactic vaccine against human lymphatic filariasis - evaluation of protection in non-human primates. ( 29885437 )	Khatri V....Kalyanasundaram R.	2018
17	Increasing evidence of low lymphatic filariasis prevalence in high risk Loa loa areas in Central and West Africa: a literature review. ( 29907117 )	Kelly-Hope L.A....Molyneux D.H.	2018
18	Information technology in morbidity management of human lymphatic filariasis-A promising tool in global programme for elimination of lymphatic filariasis. ( 29916444 )	Devi R.R....Raju V.	2018
19	Molecular xenomonitoring for post-validation surveillance of lymphatic filariasis in Togo: no evidence for active transmission. ( 29361964 )	Dorkenoo M.A....Boakye D.A.	2018
20	Innovative Surveillance Strategies to Support the Elimination of Filariasis in Africa. ( 29958813 )	Kelly-Hope L.A....Molyneux D.H.	2018
21	Integrated risk mapping and landscape characterisation of lymphatic filariasis and loiasis in South West Nigeria. ( 29774296 )	Brant T.A....Kelly-Hope L.A.	2018
22	Are Alternative Strategies Required to Accelerate the Global Elimination of Lymphatic Filariasis? Insights From Mathematical Models. ( 29860286 )	Stolk W.A....de Vlas S.J.	2018
23	Low incidence of helminth infections (schistosomiasis, strongyloidiasis, filariasis, toxocariasis) among Dutch long-term travelers: A prospective study, 2008-2011. ( 29847574 )	Overbosch F.W....Sonder G.J.B.	2018
24	Integrated morbidity mapping of lymphatic filariasis and podoconiosis cases in 20 co-endemic districts of Ethiopia. ( 29965963 )	Kebede B....Mackenzie C.D.	2018
25	<i>Carica papaya</i> (Papaya) latex: a new paradigm to combat against dengue and filariasis vectors<i>Aedes aegypti</i>and<i>Culex quinquefasciatus</i>(Diptera: Culicidae). ( 29430347 )	Chandrasekaran R....Sivaperumal S.	2018
26	Geographical distribution and species identification of human filariasis and onchocerciasis in Bioko Island, Equatorial Guinea. ( 29289559 )	Ta T.H....Rubio J.M.	2018
27	Elimination of lymphatic filariasis in west African urban areas: is implementation of mass drug administration necessary? ( 29402636 )	Koudou B.G....Molyneux D.H.	2018
28	Human infection with sub-periodic Brugia spp. in Gampaha District, Sri Lanka: a threat to filariasis elimination status? ( 29378620 )	Mallawarachchi C.H....De Silva N.R.	2018
29	Island-Wide Surveillance of Gastrointestinal Protozoan Infections on Fiji by Expanding Lymphatic Filariasis Transmission Assessment Surveys as an Access Platform. ( 29405101 )	Kim S.H....Stothard J.R.	2018
30	Green synthesis of silver nanoparticles using Holarrhena antidysenterica (L.) Wall.bark extract and their larvicidal activity against dengue and filariasis vectors. ( 29250727 )		2018
31	Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis. ( 29308790 )		2018
32	Community perspectives on persistent transmission of lymphatic filariasis in three hotspot districts in Ghana after 15 rounds of mass drug administration: a qualitative assessment. ( 29433461 )		2018
33	Lymphatic Endothelial Cell in Endemic Bancroftian Filariasis: A Focus on the Lymphatics of the Tunica Vaginalis Testis. ( 29861747 )		2018
34	Progress on elimination of lymphatic filariasis in Sierra Leone. ( 29866207 )		2018
35	Cervical Lymphatic Filariasis in a Pediatric Patient: Case Report and Database Analysis of Lymphatic Filariasis in the United States. ( 29848402 )		2018
36	Evaluation of Treatment Coverage and Enhanced Mass Drug Administration for Onchocerciasis and Lymphatic Filariasis in Five Local Government Areas Treating Twice Per Year in Edo State, Nigeria. ( 29943709 )		2018
37	Economic evaluations of lymphatic filariasis interventions: a systematic review and research needs. ( 29391042 )		2018
38	Acute scrotum: Hansen's disease versus filariasis. ( 29900901 )		2018
39	Protection of the house against Chagas disease, dengue, leishmaniasis, and lymphatic filariasis: a systematic review. ( 29074038 )	Horstick O...Runge-Ranzinger S	2018
40	Lymphatic Filariasis Presenting as a Swelling over the Upper Arm: A Case Report. ( 29725519 )	Sharma GM...Dubey S	2018
41	Morbidity management and disability prevention for lymphatic filariasis in Sri Lanka: Current status and future prospects. ( 29746479 )	Chandrasena N...de Silva NR	2018
42	Lymphatic filariasis elimination programme in Assam, India, needs change in mass drug administration strategy to target the focus of infection. ( 29749354 )	Khan AM	2018
43	Field evaluation of the biolarvicide, spinosad 20 per cent emulsifiable concentrate in comparison to its 12 per cent suspension concentrate formulation against Culex quinquefasciatus, the vector of bancroftian filariasis in India. ( 29749358 )	Sadanandane C...Jambulingam P	2018
44	Adverse events following single dose treatment of lymphatic filariasis: Observations from a review of the literature. ( 29768412 )	Budge PJ...Weil GJ	2018
45	Mapping and modelling the impact of mass drug adminstration on filariasis prevalence in Myanmar. ( 29855355 )	Aye NN...Kelly-Hope LA	2018
46	Inhibition efficiency of a newly isolated flavonoid compound from Vitex negundo L. leaves against cattle-endosymbiont Setaria cervi: Phytomedicine for lymphatic filariasis. ( 29988277 )	Rana G	2018
47	Canine filariasis in the Amazon: Species diversity and epidemiology of these emergent and neglected zoonoses. ( 29995959 )	de Arg?lo EGG...Furtado AP	2018
48	Emotional Difficulties and Experiences of Stigma among Persons with Lymphatic Filariasis in Plateau State, Nigeria. ( 30008550 )	Abdulmalik J...Eaton J	2018
49	Building Trust through Lymphatic Filariasis Elimination: A Platform to Address Social Exclusion and Human Rights in the Dominican Republic. ( 30008551 )	Keys H...Noland GS	2018
50	Identifying residual transmission of lymphatic filariasis after mass drug administration: Comparing school-based versus community-based surveillance - American Samoa, 2016. ( 30011276 )	Sheel M...Lau CL	2018

Sources

Genes for Filariasis

Genes related to Filariasis (0 elite genes):

(show all 16)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	IL5	Interleukin 5	Protein Coding	28.89	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	11138639 15501755
2	CHIT1	Chitinase 1	Protein Coding	27.12	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	17765019
3	TLR2	Toll Like Receptor 2	Protein Coding	26.94	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	14551607
4	TLR4	Toll Like Receptor 4	Protein Coding	24.71	DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	14551607
5	TLR9	Toll Like Receptor 9	Protein Coding	23.3	DISEASES inferred ¹⁵ ¹⁵ GeneCards inferred via : Publications (show sections)
6	IL10	Interleukin 10	Protein Coding	22.62	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
7	IL2	Interleukin 2	Protein Coding	21.61	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
8	IFNG	Interferon Gamma	Protein Coding	21.14	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
9	TLR6	Toll Like Receptor 6	Protein Coding	20.98	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	TLR1	Toll Like Receptor 1	Protein Coding	20.93	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	IL6	Interleukin 6	Protein Coding	20.9	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	TNF	Tumor Necrosis Factor	Protein Coding	20.86	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	CTLA4	Cytotoxic T-Lymphocyte Associated Protein 4	Protein Coding	20.85	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
14	CCL5	C-C Motif Chemokine Ligand 5	Protein Coding	20.63	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
15	FLT4	Fms Related Tyrosine Kinase 4	Protein Coding	20.53	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
16	ALB	Albumin	Protein Coding	20.16	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)

Sources

Variations for Filariasis

Sources

Expression for Filariasis

Search GEO for disease gene expression data for Filariasis.

Sources

Pathways for Filariasis

Pathways related to Filariasis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)

#	Super pathways	Score	Top Affiliating Genes
1	Innate Immune System ⁶⁶ Show member pathways Immune System ⁶⁶ Neutrophil degranulation ⁶⁶	14.05	CCL5 CHIT1 CTLA4 IFNG IL10 IL2
2	PEDF Induced Signaling ⁶⁴ Show member pathways all-trans-Retinoic Acid Signaling in Brain ⁶⁴ Cytokine-cytokine receptor interaction ³⁷ Endothelin-1 Signaling Pathway ⁶⁴ Glucocorticoid Receptor Signaling ⁶⁴ IL-6 Pathway ⁶⁴ MIF Mediated Glucocorticoid Regulation ⁶⁴ MIF Regulation of Innate Immune Cells ⁶⁴ NFAT Signaling and Lymphocyte Interactions ⁶⁴ PGC1Alpha Pathway ⁶⁴ RAR-Gamma-RXR-Alpha Degradation ⁶⁴ STAT3 Pathway ⁶⁴	13.72	CCL5 FLT4 IFNG IL10 IL2 IL5
3	TGF-Beta Pathway ⁶⁴ Show member pathways JAK-STAT Pathway ⁶⁴ JNK Pathway ⁶⁴ MAPK Family Pathway ⁶⁴ Regulation of eIF4 and p70S6K ⁶⁴ SOCS Pathway ⁶⁴	13.57	CCL5 FLT4 IFNG IL10 IL2 IL5
4	Akt Signaling ⁶⁴ Show member pathways p38 Signaling ⁶⁴ Tec Kinases Signaling ⁶⁴	13.45	CCL5 FLT4 IL10 IL2 IL5 IL6
5	Cytokine Signaling in Immune system ⁶⁶ Show member pathways Signaling by Interleukins ⁶⁶	13.39	CCL5 IFNG IL10 IL2 IL5 IL6
6	PAK Pathway ⁶⁴ Show member pathways Antioxidant Action of Vitamin-C ⁶⁴ Epithelial Adherens Junctions ⁶⁴	13.34	CCL5 FLT4 IL10 IL2 IL5 IL6
7	IL-2 Pathway ⁶⁴ Show member pathways ErbB Family Pathway ⁶⁴ ErbB2-ErbB3 Heterodimers ⁶⁴ ErbB4 Pathway ⁶⁴ Growth Hormone Signaling ⁶⁴ HMGB1 Pathway ⁶⁴ IL-4 Pathway ⁶⁴ LPS Stimulated MAPK Signaling ⁶⁴ PACAP Signaling ⁶⁴ PI3K Signaling in B-Lymphocyte ⁶⁴ Prolactin Signaling ⁶⁴ Thrombopoietin Pathway ⁶⁴ TREM1 Pathway ⁶⁴ UVC-Induced MAPK Signaling ⁶⁴	13.29	IFNG IL2 TLR1 TLR2 TLR4 TLR6
8	PI3K-Akt signaling pathway ³⁷ Show member pathways Human papillomavirus infection ³⁷	13.04	FLT4 IL2 IL6 TLR2 TLR4 TNF
9	Allograft rejection ¹ ³⁷ Show member pathways Antigen processing and presentation ³⁷ Asthma ³⁷ Autoimmune thyroid disease ³⁷ CTL Mediated Apoptosis ⁶⁴ Graft-versus-host disease ³⁷ Intestinal immune network for IgA production ³⁷ THC Differentiation Pathway ⁶⁴ Type I diabetes mellitus ³⁷ Viral myocarditis ³⁷	12.97	CTLA4 IFNG IL10 IL2 IL5 IL6
10	Toll-like Receptor Signaling Pathway ³⁷ ¹ Show member pathways Chagas disease (American trypanosomiasis) ³⁷ NOD-like receptor signaling pathway ³⁷ NOD-like Receptor Signaling Pathways ⁶⁵ Regulation of toll-like receptor signaling pathway ¹	12.96	CCL5 IFNG IL10 IL2 IL6 TLR1
11	Influenza A ³⁷ Show member pathways Herpes simplex infection ³⁷ Measles ³⁷	12.9	CCL5 IFNG IL2 IL6 TLR2 TLR4
12	Pathways in cancer ³⁷	12.86	FLT4 IFNG IL2 IL5 IL6
13	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways ⁶⁶ Show member pathways Cytosolic DNA-sensing pathway ³⁷ Immune response TLR3 and TLR4 induce TICAM1-specific signaling pathway ²² Negative regulators of RIG-I/MDA5 signaling ⁶⁶ NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 ⁶⁶ RIG-I-like Receptor Signaling ¹ RIG-I-like receptor signaling pathway ³⁷ TRAF3-dependent IRF activation pathway ⁶⁶ TRAF6 mediated IRF7 activation ⁶⁶ Virus Detection and Induction of Antiviral Signaling Pathways by RIG-I-like Receptors (RLR) ⁶⁵	12.8	CCL5 IFNG IL6 TLR4 TNF
14	NF-KappaB Family Pathway ⁶⁴ Show member pathways NF-KappaB (p50-p65) Pathway ⁶⁴	12.78	FLT4 IL2 IL6 TLR1 TLR2 TLR4
15	TRAF Pathway ⁶⁴ Show member pathways 14-3-3 Induced Apoptosis ⁶⁴ TNF Superfamily Pathway ⁶⁴ Toll-Like Receptors Pathway ⁶⁴	12.73	FLT4 TLR1 TLR2 TLR4 TLR6 TLR9
16	Th17 cell differentiation ³⁷ Show member pathways IL-22 Pathway ⁶⁴ Immune response IL-22 signaling pathway ²² Inflammatory bowel disease (IBD) ³⁷ Th1 and Th2 cell differentiation ³⁷	12.7	IFNG IL10 IL2 IL5 IL6 TLR2
17	Immune response IL-23 signaling pathway ²² Show member pathways Angiopoietin receptor Tie2-mediated signaling ¹ Angiopoietin-TIE2 Signaling ⁶⁴ Development Angiopoietin - Tie2 signaling ²² Development PDGF signaling via STATs and NF-kB ²² IL23-mediated signaling events ¹ Immune response IL-10 signaling pathway ²² Rac1/Pak1/p38/MMP-2 pathway ¹	12.65	IFNG IL10 IL2 IL6 TNF
18	T cell receptor signaling pathway ³⁷ Show member pathways T-Cell antigen Receptor (TCR) Signaling Pathway ¹ T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection ¹	12.55	CTLA4 IFNG IL10 IL2 IL5 IL6
19	VEGF Pathway (Qiagen) ²² Show member pathways CCKBR-Gastrin Stimulated Signaling ⁶⁴ Neurophilin interactions with VEGF and VEGFR ⁶⁶ VEGF Family Ligands and Receptor Interactions ⁶⁴ VEGF Pathway ⁶⁴	12.52	FLT4 TLR1 TLR2 TLR4 TLR6 TLR9
20	Antigen processing-Cross presentation ⁶⁶ Show member pathways Cross-presentation of particulate exogenous antigens (phagosomes) ⁶⁶ Endosomal/Vacuolar pathway ⁶⁶ ER-Phagosome pathway ⁶⁶ Immune response Antigen presentation by MHC class I ²²	12.49	TLR1 TLR2 TLR4 TLR6
21	JAK-STAT signaling pathway (KEGG) ³⁷ Show member pathways Interleukin-19, 20, 22, 24 ⁶⁶ Jak/STAT Signaling Pathway ⁶⁵	12.48	IFNG IL10 IL2 IL5 IL6
22	Selenium Micronutrient Network ¹ Show member pathways Folate Metabolism ¹ Metabolism of ingested MeSeO2H into MeSeH ⁶⁶ thioredoxin pathway ¹ Vitamin B12 Metabolism ¹	12.46	ALB CCL5 IFNG IL2 IL6 TNF
23	IL-17 Family Signaling Pathways ⁶⁵ Show member pathways IL17 signaling pathway ¹ IL-17 signaling pathway ³⁷ Interleukin-17 signaling ⁶⁶ Mucin expression in CF via IL-6, IL-17 signaling pathways ²²	12.44	IFNG IL5 IL6 TLR2 TNF
24	Diseases associated with the TLR signaling cascade ⁶⁶ Show member pathways Diseases of Immune System ⁶⁶ Interleukin-1 Induced Activation of NF-kappa-B ¹ IRAK1 recruits IKK complex ⁶⁶ IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation ⁶⁶ IRAK4 deficiency (TLR2/4) ⁶⁶ IRAK4 deficiency (TLR5) ⁶⁶ MyD88 deficiency (TLR2/4) ⁶⁶ MyD88 deficiency (TLR5) ⁶⁶ Simplified Depiction of MYD88 Distinct Input-Output Pathway ¹ TLR4 Signaling and Tolerance ¹ Toll-like Receptor Signaling ¹	12.39	IL6 TLR1 TLR2 TLR4 TLR6 TLR9
25	Toxoplasmosis ³⁷ Show member pathways Leishmaniasis ³⁷	12.37	IFNG IL10 TLR2 TLR4 TNF
26	Immune response IFN alpha/beta signaling pathway ²² Show member pathways Cytokine Network ⁶⁴ Interferon alpha/beta signaling ⁶⁶ Regulation of IFNA signaling ⁶⁶	12.37	FLT4 IFNG IL10 IL2 IL5 IL6
27	NF-kappaB Signaling ⁴	12.37	CCL5 CTLA4 IFNG IL10 IL2 TLR1
28	Toll Comparative Pathway ⁶⁴ Show member pathways IL-1 Pathway ⁶⁴ Immune response MIF in innate immunity response ²² iNOS Signaling ⁶⁴ TLR-TRIF Pathway ⁶⁴	12.34	IFNG IL6 TLR4 TNF
29	C-type lectin receptor signaling pathway ³⁷ Show member pathways Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways ⁶⁵	12.33	IL10 IL2 IL6 TLR9 TNF
30	G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins ²² Show member pathways G-protein signaling G-Protein alpha-12 signaling pathway ²²	12.29	CCL5 TLR1 TLR2 TLR4 TLR6 TLR9
31	Bacterial infections in CF airways ²² Show member pathways IL-1 beta-dependent CFTR expression ²² Immune response Bacterial infections in normal airways ²² Immune response TLR signaling pathways ²²	12.25	IFNG IL6 TLR1 TLR2 TLR4 TLR6
32	Colorectal Cancer Metastasis ⁶⁴	12.22	IFNG IL6 TLR1 TLR2 TLR4 TLR6
33	Immune response IFN gamma signaling pathway ²² Show member pathways IFN-gamma pathway ¹	12.19	CCL5 FLT4 IFNG IL10 IL2 IL5
34	Spinal Cord Injury ¹	12.14	IFNG IL2 IL6 TLR4 TNF
35	Microglia Activation During Neuroinflammation: Overview ⁶⁵ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁵	12.14	IFNG IL6 TLR1 TLR2 TLR4 TLR6
36	Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁵	12.13	IFNG IL10 IL2 IL5 IL6 TNF
37	MAPK Pathway ⁷² Show member pathways Toll-like Receptor Pathway ⁷²	12.11	IL2 IL5 TLR1 TLR2 TLR4 TLR6
38	Amoebiasis ³⁷	12.04	IFNG IL10 IL6 TLR2 TLR4 TNF
39	Interleukin-4 and 13 signaling ⁶⁶	11.98	IL10 IL6 TNF
40	Phagocytosis of Microbes ⁶⁴	11.97	TLR1 TLR2 TLR4 TLR6 TLR9
41	TNF signaling pathway ³⁷	11.96	CCL5 IL6 TNF
42	Jak-Stat Signaling Pathway (sino) ⁶⁷	11.96	IFNG IL10 IL2 IL6
43	Rheumatoid arthritis ³⁷	11.96	CCL5 CTLA4 IFNG IL6 TLR2 TLR4
44	Innate Lymphoid Cell Differentiation Pathways ⁶⁵	11.94	IFNG IL10 IL2 IL5 TNF
45	HIF-1 signaling pathway ³⁷	11.92	IFNG IL6 TLR4
46	Glucocorticoid receptor regulatory network ¹	11.92	IFNG IL2 IL5 IL6
47	Hematopoietic cell lineage ³⁷	11.91	IL5 IL6 TNF
48	Calcineurin-regulated NFAT-dependent transcription in lymphocytes ¹ Show member pathways Calcium signaling in the CD4+ TCR pathway ¹	11.9	CTLA4 IFNG IL2 IL5 TNF
49	Pertussis ³⁷	11.89	IL10 IL6 TLR4 TNF
50	Dendritic Cells Developmental Lineage Pathway ⁶⁵	11.89	IFNG IL10 IL2 IL6 TLR9 TNF

Sources

GO Terms for Filariasis

Cellular components related to Filariasis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	integral component of plasma membrane	GO:0005887	9.8	CTLA4 FLT4 TLR1 TLR2 TLR4 TLR6
2	membrane raft	GO:0045121	9.62	TLR1 TLR2 TLR6 TNF
3	extracellular space	GO:0005615	9.61	ALB CCL5 CHIT1 IFNG IL10 IL2
4	phagocytic vesicle membrane	GO:0030670	9.54	TLR1 TLR2 TLR6
5	extracellular region	GO:0005576	9.36	ALB CCL5 CHIT1 FLT4 IFNG IL10
6	Toll-like receptor 1-Toll-like receptor 2 protein complex	GO:0035354	9.16	TLR1 TLR2

Biological processes related to Filariasis according to GeneCards Suite gene sharing:

(show top 50) (show all 98)

#	Name	GO ID	Score	Top Affiliating Genes
1	positive regulation of DNA-binding transcription factor activity	GO:0051091	9.97	IL10 IL5 IL6 TNF
2	response to virus	GO:0009615	9.95	CCL5 IFNG TNF
3	positive regulation of JNK cascade	GO:0046330	9.95	FLT4 TLR4 TLR9 TNF
4	cellular response to interferon-gamma	GO:0071346	9.94	CCL5 TLR2 TLR4
5	defense response to Gram-positive bacterium	GO:0050830	9.94	IL6 TLR2 TNF
6	defense response to Gram-negative bacterium	GO:0050829	9.94	IL6 TLR4 TLR9
7	positive regulation of tyrosine phosphorylation of STAT protein	GO:0042531	9.93	CCL5 IFNG IL2 IL6
8	regulation of insulin secretion	GO:0050796	9.92	CCL5 IFNG TNF
9	response to glucocorticoid	GO:0051384	9.92	IL10 IL6 TNF
10	I-kappaB kinase/NF-kappaB signaling	GO:0007249	9.91	TLR4 TLR9 TNF
11	positive regulation of T cell proliferation	GO:0042102	9.91	CCL5 IL2 IL6
12	humoral immune response	GO:0006959	9.91	IFNG IL6 TNF
13	positive regulation of smooth muscle cell proliferation	GO:0048661	9.9	CCL5 IL6 TNF
14	positive regulation of tumor necrosis factor production	GO:0032760	9.9	TLR2 TLR4 TLR9
15	positive regulation of interferon-gamma production	GO:0032729	9.89	IL2 TLR4 TNF
16	positive regulation of JUN kinase activity	GO:0043507	9.88	TLR6 TLR9 TNF
17	positive regulation of NIK/NF-kappaB signaling	GO:1901224	9.88	TLR2 TLR4 TLR9 TNF
18	positive regulation of NF-kappaB transcription factor activity	GO:0051092	9.88	IL6 TLR2 TLR4 TLR6 TLR9 TNF
19	positive regulation of nitric oxide biosynthetic process	GO:0045429	9.87	IFNG TLR4 TLR6 TNF
20	positive regulation of B cell proliferation	GO:0030890	9.86	IL2 IL5 TLR4 TLR9
21	positive regulation of interferon-beta production	GO:0032728	9.85	TLR2 TLR4 TLR9
22	lipopolysaccharide-mediated signaling pathway	GO:0031663	9.85	CCL5 TLR2 TLR4 TNF
23	positive regulation of inflammatory response	GO:0050729	9.85	IL2 TLR2 TLR4 TLR9 TNF
24	positive regulation of JAK-STAT cascade	GO:0046427	9.84	CCL5 IL5 IL6
25	positive regulation of interleukin-10 production	GO:0032733	9.83	TLR2 TLR4 TLR9
26	microglial cell activation	GO:0001774	9.83	TLR2 TLR6 TNF
27	positive regulation of interleukin-6 production	GO:0032755	9.83	IL6 TLR2 TLR4 TLR9 TNF
28	positive regulation of macrophage activation	GO:0043032	9.82	IL10 TLR4 TLR6
29	regulation of regulatory T cell differentiation	GO:0045589	9.81	CTLA4 IFNG IL2
30	negative regulation of interleukin-6 production	GO:0032715	9.81	IL10 TLR4 TLR9 TNF
31	positive regulation of nitric-oxide synthase biosynthetic process	GO:0051770	9.8	TLR2 TLR4 TLR9
32	cell activation	GO:0001775	9.8	TLR1 TLR2 TLR6
33	positive regulation of interleukin-8 production	GO:0032757	9.8	TLR2 TLR4 TLR9 TNF
34	I-kappaB phosphorylation	GO:0007252	9.79	TLR2 TLR4 TLR9
35	positive regulation of immunoglobulin secretion	GO:0051024	9.79	IL2 IL5 IL6
36	positive regulation of cytokine production involved in inflammatory response	GO:1900017	9.78	TLR4 TLR6
37	positive regulation of glial cell proliferation	GO:0060252	9.78	IL6 TNF
38	response to molecule of bacterial origin	GO:0002237	9.78	IL10 TLR2 TLR9
39	positive regulation of interleukin-12 production	GO:0032735	9.78	IFNG TLR2 TLR4 TLR9
40	negative regulation of B cell proliferation	GO:0030889	9.77	CTLA4 IL10
41	positive regulation of membrane protein ectodomain proteolysis	GO:0051044	9.77	IFNG TNF
42	negative regulation of growth of symbiont in host	GO:0044130	9.77	IL10 TNF
43	positive regulation of heterotypic cell-cell adhesion	GO:0034116	9.77	IL10 TNF
44	positive regulation of interleukin-8 secretion	GO:2000484	9.77	TLR1 TLR2
45	positive regulation of reactive oxygen species biosynthetic process	GO:1903428	9.77	TLR4 TLR6
46	positive regulation of interleukin-8 biosynthetic process	GO:0045416	9.77	TLR4 TLR9 TNF
47	toll-like receptor signaling pathway	GO:0002224	9.77	TLR1 TLR2 TLR4 TLR6 TLR9
48	negative regulation of interleukin-17 production	GO:0032700	9.76	IFNG TLR4
49	positive regulation of podosome assembly	GO:0071803	9.76	IL5 TNF
50	macrophage activation	GO:0042116	9.76	TLR1 TLR4

Molecular functions related to Filariasis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	identical protein binding	GO:0042802	9.87	ALB CCL5 TLR1 TLR2 TLR4 TLR6
2	signaling receptor activity	GO:0038023	9.73	TLR1 TLR2 TLR4 TLR6
3	growth factor activity	GO:0008083	9.67	IL10 IL2 IL5 IL6
4	transmembrane signaling receptor activity	GO:0004888	9.55	FLT4 TLR1 TLR4 TLR6 TLR9
5	signaling pattern recognition receptor activity	GO:0008329	9.46	TLR2 TLR9
6	lipopolysaccharide receptor activity	GO:0001875	9.4	TLR2 TLR4
7	Toll-like receptor 2 binding	GO:0035663	9.26	TLR1 TLR6
8	cytokine activity	GO:0005125	9.17	CCL5 IFNG IL10 IL2 IL5 IL6
9	lipopeptide binding	GO:0071723	9.13	TLR1 TLR2 TLR6
10	protein binding	GO:0005515	10.32	ALB CCL5 CTLA4 FLT4 IFNG IL10

Sources

Sources for Filariasis

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

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²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia