MCID: FLR002
MIFTS: 58

Filariasis

Categories: Infectious diseases

Aliases & Classifications for Filariasis

MalaCards integrated aliases for Filariasis:

Name: Filariasis 12 76 55 44 15 73
Disease Due to Superfamily Filarioidea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1080
ICD9CM 35 125.9
MeSH 44 D005368
NCIt 50 C34611
SNOMED-CT 68 50342004
UMLS 73 C0016085

Summaries for Filariasis

Disease Ontology : 12 A parasitic helminthiasis infectious disease that involves parasitic infection of the lymphatics and subcutaneous tissue by nematodes of the superfamily Filarioidea.

MalaCards based summary : Filariasis, also known as disease due to superfamily filarioidea, is related to filarial elephantiasis and onchocerciasis. An important gene associated with Filariasis is IL5 (Interleukin 5), and among its related pathways/superpathways are Innate Immune System and PEDF Induced Signaling. The drugs Ivermectin and Albendazole have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and t cells, and related phenotypes are immune system and digestive/alimentary

Wikipedia : 76 Filariasis is a parasitic disease caused by an infection with roundworms of the Filarioidea type. These... more...

Related Diseases for Filariasis

Diseases related to Filariasis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 407)
# Related Disease Score Top Affiliating Genes
1 filarial elephantiasis 33.9 IL10 IL5 TLR2 TLR9
2 onchocerciasis 32.2 CCL5 IL2 IL5
3 endomyocardial fibrosis 30.3 IL10 TNF
4 schistosomiasis 30.0 ALB IFNG IL10 IL2 IL5 TNF
5 lymphangiosarcoma 30.0 FLT4 IL2 TNF
6 parasitic helminthiasis infectious disease 29.8 IL10 IL2 IL5 TLR9 TNF
7 lichen planus 29.6 IFNG TLR9 TNF
8 pericarditis 29.5 IFNG IL6 TNF
9 tetanus 29.5 IFNG IL10 IL2 IL5
10 uveitis 29.5 CTLA4 IFNG IL10 TNF
11 arthritis 29.4 IFNG IL10 IL6 TNF
12 chagas disease 29.2 IFNG IL10 IL2 IL6 TLR2 TLR4
13 leishmaniasis 29.1 IFNG IL10 IL2 IL5 IL6 TLR2
14 hemorrhagic fever 29.1 ALB IFNG IL10 IL6 TNF
15 dengue hemorrhagic fever 29.1 ALB IFNG IL10 IL6 TNF
16 parasitic protozoa infectious disease 28.9 IFNG IL10 IL2 IL6 TLR2 TLR9
17 malaria 28.9 TNF TLR9 TLR4 TLR2 IL6 IL5
18 visceral leishmaniasis 28.8 ALB IFNG IL10 IL2 TLR2 TLR4
19 trypanosomiasis 28.4 TNF TLR9 TLR2 IL6 IL2 IL10
20 rheumatoid arthritis 28.3 CCL5 CTLA4 IFNG IL10 IL2 IL6
21 loiasis 12.1
22 dirofilariasis 11.6
23 lymphedema 11.4
24 elephantiasis 11.4
25 mansonelliasis 11.4
26 podoconiosis 11.3
27 setariasis 11.0
28 dipetalonemiasis 11.0
29 hydrocele 10.4
30 prosthetic joint infection 10.3 TLR2 TLR4
31 necatoriasis 10.3 IL10 IL5
32 pouchitis 10.3 IL10 TLR4
33 eosinophilic fasciitis 10.3 IFNG IL5
34 hyperlucent lung 10.3 IFNG IL10
35 sporotrichosis 10.3 IFNG IL10
36 berylliosis 10.3 IFNG IL2
37 fixed drug eruption 10.3 IFNG IL2
38 periodontitis, chronic 10.2 IL6 TLR2
39 gaucher disease, type ii 10.2 IL10 IL2 IL5
40 bagassosis 10.2 IL5 IL6
41 mycosis fungoides 10.2 CTLA4 IL2 IL5
42 keratitis, hereditary 10.2 TLR2 TLR4 TLR9
43 autoimmune lymphoproliferative syndrome 10.2 CTLA4 IL10 IL2
44 acute transverse myelitis 10.2 IL10 IL6
45 suppurative otitis media 10.2 TLR2 TLR4 TLR9
46 septic arthritis 10.2 TLR2 TLR4 TLR9
47 respiratory allergy 10.2 IL10 IL5 TLR9
48 nasal cavity disease 10.2 IL10 IL5 TLR9
49 extrapulmonary tuberculosis 10.2 IFNG IL10 TLR2
50 ige responsiveness, atopic 10.2 IFNG IL10 IL5

Graphical network of the top 20 diseases related to Filariasis:



Diseases related to Filariasis

Symptoms & Phenotypes for Filariasis

MGI Mouse Phenotypes related to Filariasis:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 10.31 CCL5 CHIT1 CTLA4 FLT4 IFNG IL10
2 digestive/alimentary MP:0005381 10.29 ALB CTLA4 FLT4 IFNG IL10 IL2
3 hematopoietic system MP:0005397 10.29 CCL5 CTLA4 IFNG IL10 IL2 IL5
4 homeostasis/metabolism MP:0005376 10.23 ALB CTLA4 FLT4 IFNG IL10 IL2
5 cardiovascular system MP:0005385 10.18 CTLA4 FLT4 IFNG IL10 IL2 IL6
6 liver/biliary system MP:0005370 10.11 ALB CTLA4 FLT4 IFNG IL10 IL2
7 endocrine/exocrine gland MP:0005379 10.1 ALB CTLA4 IFNG IL10 IL2 IL6
8 mortality/aging MP:0010768 10.06 ALB CTLA4 FLT4 IFNG IL10 IL2
9 integument MP:0010771 10.01 CTLA4 FLT4 IFNG IL10 IL6 TLR2
10 muscle MP:0005369 9.86 ALB FLT4 IFNG IL10 IL6 TLR2
11 neoplasm MP:0002006 9.81 ALB IFNG IL10 IL2 IL5 IL6
12 reproductive system MP:0005389 9.61 FLT4 IFNG IL10 IL2 IL5 IL6
13 respiratory system MP:0005388 9.28 CTLA4 IFNG IL10 IL2 IL5 IL6

Drugs & Therapeutics for Filariasis

Drugs for Filariasis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 50)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ivermectin Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 70288-86-7 6474909
2
Albendazole Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 54965-21-8 2082
3
Diethylcarbamazine Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 90-89-1 3052
4
Doxycycline Approved, Investigational, Vet_approved Phase 4,Phase 3,Phase 2 564-25-0 54671203
5
Azithromycin Approved Phase 4,Phase 3,Phase 2,Not Applicable 83905-01-5 55185 447043
6
Praziquantel Approved, Investigational, Vet_approved Phase 4,Phase 1,Not Applicable 55268-74-1 4891
7 Anti-Infective Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
8 Antiprotozoal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
9 Antiparasitic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
10 Antimitotic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
11 Anthelmintics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
12 Lipoxygenase Inhibitors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
13 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable
14 Antimalarials Phase 4,Phase 3,Phase 2
15 Anticonvulsants Phase 4
16
Petrolatum Approved, Investigational Phase 3 8009-03-8
17
Glycerol Approved, Investigational Phase 3 56-81-5 753
18 Disinfectants Phase 3
19 Protective Agents Phase 3
20 Eusol Phase 3
21 Sodium hypochlorite Phase 3
22 Vitamins Phase 3
23 Milbemycin Phase 3,Phase 2
24 Reslizumab Approved, Investigational Phase 2
25
Rifampicin Approved Phase 2 13292-46-1 5458213 5381226
26
Dihydroartemisinin Experimental, Investigational Phase 2 71939-50-9 6918483
27
Piperaquine Experimental, Investigational Phase 2 4085-31-8 5079497
28 Artemisinine Phase 2
29 Artemisinins Phase 2
30 Anti-Asthmatic Agents Phase 2
31 Antibodies, Monoclonal Phase 2
32 Antibodies Phase 2
33 Respiratory System Agents Phase 2
34 Immunoglobulins Phase 2
35 Antitubercular Agents Phase 2
36 Antibiotics, Antitubercular Phase 2
37 Cytochrome P-450 CYP3A Inducers Phase 2
38 Nucleic Acid Synthesis Inhibitors Phase 2
39 Imatinib Mesylate Phase 2 220127-57-1 123596
40 Protein Kinase Inhibitors Phase 2
41
Romidepsin Approved, Investigational Phase 1 128517-07-7 5352062
42 Pharmaceutical Solutions Phase 1
43
Mebendazole Approved, Vet_approved 31431-39-7 4030
44
Piperazine Approved, Vet_approved 110-85-0 4837
45
Permethrin Approved, Investigational Not Applicable 52645-53-1 40326
46
Citric Acid Approved, Nutraceutical, Vet_approved 77-92-9 311
47
Suramin Investigational 145-63-1 5361
48 Citrate
49 Piperazine citrate
50 Liver Extracts Not Applicable

Interventional clinical trials:

(show top 50) (show all 67)
# Name Status NCT ID Phase Drugs
1 Impact of Albendazole -Ivermectin on Wuchereria Bancrofti in Mali Completed NCT02784743 Phase 4 ''albendazole'' and ''ivermectin''
2 Post-treatment Effects of Ivermectin (IVM) or Diethylcarbamazine (DEC) in Loiasis Completed NCT01593722 Phase 4 Diethylcarbamazine;Ivermectin
3 Alternate Chemotherapy Regimens for the Clearance of W.Bancrofti Infection Completed NCT02005653 Phase 4 Diethylcarbamazine;Albendazole;Doxycycline
4 Ivermectin Treatment in Patients With Onchocerciasis-associated Epilepsy Completed NCT03052998 Phase 4 Ivermectin
5 Twice Yearly Treatment for the Control of LF Recruiting NCT03036059 Phase 4 400 μg/kg Ivermectin + 400 mg Albendazole
6 Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH) Recruiting NCT03014167 Phase 4 Albendazole
7 Cluster RCT of Co-administration Azithromycin, Albendazole & Ivermectin Not yet recruiting NCT03570814 Phase 4 Administration of Albendazole on Day 1;Administration of Ivermectin on Day 1;Administration of Azithromycin on Day 1;Administration of Azithromycin on Day 15
8 Safety Study of Combined Azithromycin, Ivermectin and Albendazole for Trachoma and Lymphatic Filariasis Withdrawn NCT01903057 Phase 4 azithromycin;ivermectin;albendazole;placebo
9 Effect of Concomitant Mansonella Perstans Microfilaremia on Immune Responses Following Single Dose Praziquantel in People With Schistosomiasis Withdrawn NCT02734186 Phase 4 Praziquantel
10 Repeat Ivermectin Mass Drug Administrations for Control of Malaria: a Pilot Safety and Efficacy Study Completed NCT02509481 Phase 2, Phase 3 Ivermectin;Albendazole
11 An RCT to Evaluate the Effect of a New Skin Care Regimen on SBF in Those With Podoconiosis Completed NCT02839772 Phase 3
12 IVM Alone vs ALB + IVM Against Onchocerciasis Completed NCT03238131 Phase 3 Ivermectin;Albendazole
13 Study Comparing Moxidectin And Ivermectin In Subjects With Onchocerca Volvulus Infection Completed NCT00790998 Phase 3 Moxidectin;Ivermectin
14 A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali Recruiting NCT02927496 Phase 3 Doxycycline;Placebo
15 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in Sri Lanka Recruiting NCT02929134 Phase 3 Doxycycline;Placebo
16 Efficacy of Ivermectin and Albendazole Against Onchocerciasis in the Volta Region, Ghana Active, not recruiting NCT02078024 Phase 3 IVM plus ALB;IVM
17 A 24 Month Study to Compare Efficacy of Doxycycline vs Placebo for Improving Filarial Lymphedema in India Not yet recruiting NCT02929121 Phase 3 Doxycycline;Placebo
18 Safety of Co-administration of IDA and Azithromycin for NTDs ( ComboNTDs ) Not yet recruiting NCT03676140 Phase 3 Albendazole on Day 1;Ivermectin on Day 1;Diethylcarbamazine on day 1;Azithromycin on Day 1;Azithromycin on Day 8
19 Effect of Albendazole Dose on Treatment of Lymphatic Filariasis Completed NCT00511004 Phase 2 Albendazole;Diethylcarbamazine
20 Doxycycline to Treat Mansonella Perstans Infection in Patients With and Without Lymphatic Filariasis Completed NCT00340691 Phase 2 Doxycycline
21 Effect of Albendazole Dose on Clearance of Filarial Worms Completed NCT00339417 Phase 2 Albendazole;Ivermectin
22 Eval 3-Drug Therapy Diethylcarbamize, Albendazole and Ivermectin That Could Accelerate LF Elimination Outside of Africa Completed NCT01975441 Phase 2 Diethylcarbamazine;Albendazole;Ivermectin
23 Effect of Albendazole Dose on Clearance of Filarial Worms Completed NCT00375583 Phase 2 DEC/Albendazole
24 Efficacy and Safety of High-dose Ivermectin for Reducing Malaria Transmission: A Dose Finding Study Completed NCT02511353 Phase 2 ivermectin;placebo;dihydroartemisinin-piperaquine
25 Reslizumab to Prevent Post-treatment Eosinophilia in Loiasis Completed NCT01111305 Phase 2 Reslizumab;Diethylcarbamazine
26 Study Evaluating Orally Administered Moxidectin In Subjects With Onchocerca Volvulus Infection Completed NCT00300768 Phase 2 2 mg moxidectin;ivermectin 150 mcg/kg;4 mg moxidectin;8 mg moxidectin
27 Clinical Trial of Rifampin and Azithromycin for the Treatment of River Blindness Completed NCT00127504 Phase 2 Rifampin;Azithromycin
28 Concomitant Infections of Mansonella Perstans in Tuberculosis and Buruli Ulcer Disease Patients From Ghana Completed NCT02281643 Phase 2 Doxycycline
29 PK PD Study of IDA and Azithromycin for NTDs ( ComboNTDs ) Not yet recruiting NCT03664063 Phase 2 Azithromycin;Albendazole;Ivermectin;Diethylcarbamazine
30 Efficacy and Microfilaricidal Kinetics of Imatinib for the Treatment of Loa Loa Not yet recruiting NCT02644525 Phase 2 Imatinib Mesylate;Placebo
31 Pediatric Pharmacokinetics And Safety Study Of Moxidectin Withdrawn NCT01035619 Phase 2 moxidectin
32 Relative Bioavailability Study of Emodepside IR-tablets and Solution Completed NCT03383523 Phase 1 Emodepside (BAY 44-4400)
33 First in Man Clinical Trial of Emodepside (BAY 44-4400) Completed NCT02661178 Phase 1 emodepside (BAY 44-4400);placebo
34 Safety, Tolerability and PK of Multiple-ascending Doses of Emodepside Recruiting NCT03383614 Phase 1 LSF emodepside (BAY 44-4400) oral solution (1mg/mL)
35 Pharmacokinetics & Pharmacodynamics of Diethylcarbamazine (DEC)+ Albendazole (ALB) + Ivermectin (IVE) Active, not recruiting NCT02845713 Phase 1 Ivermectin, Diethylcarbamazine Albendazole (IDA)
36 Exhaled NO Testing in Filariasis Completed NCT01628497
37 Disability and Quality of Life in Patients With Lymphatic Filariasis in Rural Southern India Completed NCT01629771
38 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis Completed NCT01905423 Albendazole and diethylcarbamazine
39 Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast) Completed NCT02032043 Annual versus Semiannual Albendazole plus Ivermectin MDA
40 Research for Elimination of Lymphatic Filariasis (ICIDR) Completed NCT00406627
41 Research for Elim of Filariasis Completed NCT00145223
42 Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia Completed NCT01905436 Annual versus Semiannual Albendazole plus Ivermectin Mass Drug Administration
43 Interaction Between HIV and Lymphatic Filariasis Completed NCT00295698 Not Applicable Diethylcarbamazine
44 Fiji Integrated Therapy (FIT) - Triple Therapy for Lymphatic Filariasis, Scabies and Soil Transmitted Helminths in Fiji Completed NCT03177993 Not Applicable 3 drug dose - IDA;3 drug dose - IDA with second dose of ivermectin;2 drug dose - DA
45 Medical Implications of Coinfection With Malaria and Filariasis Parasites Completed NCT00471666
46 Safety of the Co-administration of Three Drugs for Trachoma and Lymphatic Filariasis Elimination Completed NCT01586169 Not Applicable triple co administration at once of the combination of Albendazole + ivermectin + azithromycin
47 Evaluation of Antibacterial Soap for Treatment of Lymphedema in a Filariasis-Endemic Area Completed NCT00139100 Not Applicable antimicrobial agent in soap
48 Prevalence of LF Infection in Districts Not Included in LF Control Activities Completed NCT03131401
49 Changes in HIV Viral Load in Patients Undergoing Treatment for Filariasis Completed NCT00344279
50 Immune Response Regulation in People Infected Concurrently With Malarial and Filarial Parasites Completed NCT00341666

Search NIH Clinical Center for Filariasis

Cochrane evidence based reviews: filariasis

Genetic Tests for Filariasis

Anatomical Context for Filariasis

MalaCards organs/tissues related to Filariasis:

41
Testes, Breast, T Cells, Skin, B Cells, Lung, Eye

Publications for Filariasis

Articles related to Filariasis:

(show top 50) (show all 1431)
# Title Authors Year
1
A surveillance system for lymphatic filariasis after its elimination in Sri Lanka. ( 30308253 )
2019
2
Epididymal filariasis a rare presentation of testicular pain. ( 30306047 )
2019
3
Insecticidal efficacy of the essential oil of jambú (Acmella oleracea (L.) R.K. Jansen) cultivated in central Italy against filariasis mosquito vectors, houseflies and moth pests. ( 30149065 )
2019
4
An assessment of mosquito collection techniques for xenomonitoring of anopheline-transmitted Lymphatic Filariasis in Ghana. ( 29898803 )
2018
5
Use of the Litomosoides sigmodontis Infection Model of Filariasis to Study Type 2 Immunity. ( 29956140 )
2018
6
Perceptions, knowledge, attitudes and practices for the prevention and control of lymphatic filariasis in Conakry, Republic of Guinea. ( 29224979 )
2018
7
Prevalence of and risk factors for malaria, filariasis, and intestinal parasites as single infections or co-infections in different settlements of Gabon, Central Africa. ( 29378644 )
2018
8
Bancroftian filariasis associated with male sterility. ( 29330277 )
2018
9
Understanding heterogeneities in mosquito-bite exposure and infection distributions for the elimination of lymphatic filariasis. ( 29386362 )
2018
10
Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis. ( 29348597 )
2018
11
Multiplex serology for impact evaluation of bed net distribution on burden of lymphatic filariasis and four species of human malaria in northern Mozambique. ( 29444078 )
2018
12
Elimination of lymphatic filariasis as a public health problem from the Cook Islands. ( 29785168 )
2018
13
Prevalence of Neglected Tropical Diseases (Leishmaniasis and Lymphatic Filariasis) and Malaria Among a Migrant Labour Settlement in Kerala, India. ( 29860672 )
2018
14
Elucidation of immunological response and its regulatory network by P-TUFT-ALT-2: a promising fusion protein vaccine for human lymphatic filariasis. ( 29892388 )
2018
15
Assessing knowledge about lymphatic filariasis and the implementation of mass drug administration amongst drug deliverers in three districts/cities of Indonesia. ( 29801511 )
2018
16
Prospects of developing a prophylactic vaccine against human lymphatic filariasis - evaluation of protection in non-human primates. ( 29885437 )
2018
17
Increasing evidence of low lymphatic filariasis prevalence in high risk Loa loa areas in Central and West Africa: a literature review. ( 29907117 )
2018
18
Information technology in morbidity management of human lymphatic filariasis-A promising tool in global programme for elimination of lymphatic filariasis. ( 29916444 )
2018
19
Molecular xenomonitoring for post-validation surveillance of lymphatic filariasis in Togo: no evidence for active transmission. ( 29361964 )
2018
20
Innovative Surveillance Strategies to Support the Elimination of Filariasis in Africa. ( 29958813 )
2018
21
Integrated risk mapping and landscape characterisation of lymphatic filariasis and loiasis in South West Nigeria. ( 29774296 )
2018
22
Are Alternative Strategies Required to Accelerate the Global Elimination of Lymphatic Filariasis? Insights From Mathematical Models. ( 29860286 )
2018
23
Low incidence of helminth infections (schistosomiasis, strongyloidiasis, filariasis, toxocariasis) among Dutch long-term travelers: A prospective study, 2008-2011. ( 29847574 )
2018
24
Integrated morbidity mapping of lymphatic filariasis and podoconiosis cases in 20 co-endemic districts of Ethiopia. ( 29965963 )
2018
25
<i>Carica papaya</i> (Papaya) latex: a new paradigm to combat against dengue and filariasis vectors<i>Aedes aegypti</i>and<i>Culex quinquefasciatus</i>(Diptera: Culicidae). ( 29430347 )
2018
26
Geographical distribution and species identification of human filariasis and onchocerciasis in Bioko Island, Equatorial Guinea. ( 29289559 )
2018
27
Elimination of lymphatic filariasis in west African urban areas: is implementation of mass drug administration necessary? ( 29402636 )
2018
28
Human infection with sub-periodic Brugia spp. in Gampaha District, Sri Lanka: a threat to filariasis elimination status? ( 29378620 )
2018
29
Island-Wide Surveillance of Gastrointestinal Protozoan Infections on Fiji by Expanding Lymphatic Filariasis Transmission Assessment Surveys as an Access Platform. ( 29405101 )
2018
30
Green synthesis of silver nanoparticles using Holarrhena antidysenterica (L.) Wall.bark extract and their larvicidal activity against dengue and filariasis vectors. ( 29250727 )
2018
31
Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis. ( 29308790 )
2018
32
Community perspectives on persistent transmission of lymphatic filariasis in three hotspot districts in Ghana after 15 rounds of mass drug administration: a qualitative assessment. ( 29433461 )
2018
33
Lymphatic Endothelial Cell in Endemic Bancroftian Filariasis: A Focus on the Lymphatics of the Tunica Vaginalis Testis. ( 29861747 )
2018
34
Progress on elimination of lymphatic filariasis in Sierra Leone. ( 29866207 )
2018
35
Cervical Lymphatic Filariasis in a Pediatric Patient: Case Report and Database Analysis of Lymphatic Filariasis in the United States. ( 29848402 )
2018
36
Evaluation of Treatment Coverage and Enhanced Mass Drug Administration for Onchocerciasis and Lymphatic Filariasis in Five Local Government Areas Treating Twice Per Year in Edo State, Nigeria. ( 29943709 )
2018
37
Economic evaluations of lymphatic filariasis interventions: a systematic review and research needs. ( 29391042 )
2018
38
Acute scrotum: Hansen's disease versus filariasis. ( 29900901 )
2018
39
Protection of the house against Chagas disease, dengue, leishmaniasis, and lymphatic filariasis: a systematic review. ( 29074038 )
2018
40
Lymphatic Filariasis Presenting as a Swelling over the Upper Arm: A Case Report. ( 29725519 )
2018
41
Morbidity management and disability prevention for lymphatic filariasis in Sri Lanka: Current status and future prospects. ( 29746479 )
2018
42
Lymphatic filariasis elimination programme in Assam, India, needs change in mass drug administration strategy to target the focus of infection. ( 29749354 )
2018
43
Field evaluation of the biolarvicide, spinosad 20 per cent emulsifiable concentrate in comparison to its 12 per cent suspension concentrate formulation against Culex quinquefasciatus, the vector of bancroftian filariasis in India. ( 29749358 )
2018
44
Adverse events following single dose treatment of lymphatic filariasis: Observations from a review of the literature. ( 29768412 )
2018
45
Mapping and modelling the impact of mass drug adminstration on filariasis prevalence in Myanmar. ( 29855355 )
2018
46
Inhibition efficiency of a newly isolated flavonoid compound from Vitex negundo L. leaves against cattle-endosymbiont Setaria cervi: Phytomedicine for lymphatic filariasis. ( 29988277 )
2018
47
Canine filariasis in the Amazon: Species diversity and epidemiology of these emergent and neglected zoonoses. ( 29995959 )
2018
48
Emotional Difficulties and Experiences of Stigma among Persons with Lymphatic Filariasis in Plateau State, Nigeria. ( 30008550 )
2018
49
Building Trust through Lymphatic Filariasis Elimination: A Platform to Address Social Exclusion and Human Rights in the Dominican Republic. ( 30008551 )
2018
50
Identifying residual transmission of lymphatic filariasis after mass drug administration: Comparing school-based versus community-based surveillance - American Samoa, 2016. ( 30011276 )
2018

Variations for Filariasis

Expression for Filariasis

Search GEO for disease gene expression data for Filariasis.

Pathways for Filariasis

Pathways related to Filariasis according to GeneCards Suite gene sharing:

(show top 50) (show all 74)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
14.05 CCL5 CHIT1 CTLA4 IFNG IL10 IL2
2
Show member pathways
13.72 CCL5 FLT4 IFNG IL10 IL2 IL5
3
Show member pathways
13.57 CCL5 FLT4 IFNG IL10 IL2 IL5
4
Show member pathways
13.45 CCL5 FLT4 IL10 IL2 IL5 IL6
5
Show member pathways
13.39 CCL5 IFNG IL10 IL2 IL5 IL6
6
Show member pathways
13.34 CCL5 FLT4 IL10 IL2 IL5 IL6
7
Show member pathways
13.29 IFNG IL2 TLR1 TLR2 TLR4 TLR6
8
Show member pathways
13.04 FLT4 IL2 IL6 TLR2 TLR4 TNF
9
Show member pathways
12.97 CTLA4 IFNG IL10 IL2 IL5 IL6
10
Show member pathways
12.96 CCL5 IFNG IL10 IL2 IL6 TLR1
11
Show member pathways
12.9 CCL5 IFNG IL2 IL6 TLR2 TLR4
12 12.86 FLT4 IFNG IL2 IL5 IL6
13
Show member pathways
12.8 CCL5 IFNG IL6 TLR4 TNF
14
Show member pathways
12.78 FLT4 IL2 IL6 TLR1 TLR2 TLR4
15
Show member pathways
12.73 FLT4 TLR1 TLR2 TLR4 TLR6 TLR9
16
Show member pathways
12.7 IFNG IL10 IL2 IL5 IL6 TLR2
17
Show member pathways
12.65 IFNG IL10 IL2 IL6 TNF
18
Show member pathways
12.55 CTLA4 IFNG IL10 IL2 IL5 IL6
19
Show member pathways
12.52 FLT4 TLR1 TLR2 TLR4 TLR6 TLR9
20
Show member pathways
12.49 TLR1 TLR2 TLR4 TLR6
21
Show member pathways
12.48 IFNG IL10 IL2 IL5 IL6
22
Show member pathways
12.46 ALB CCL5 IFNG IL2 IL6 TNF
23
Show member pathways
12.44 IFNG IL5 IL6 TLR2 TNF
24
Show member pathways
12.39 IL6 TLR1 TLR2 TLR4 TLR6 TLR9
25
Show member pathways
12.37 IFNG IL10 TLR2 TLR4 TNF
26
Show member pathways
12.37 FLT4 IFNG IL10 IL2 IL5 IL6
27 12.37 CCL5 CTLA4 IFNG IL10 IL2 TLR1
28
Show member pathways
12.34 IFNG IL6 TLR4 TNF
29
Show member pathways
12.33 IL10 IL2 IL6 TLR9 TNF
30
Show member pathways
12.29 CCL5 TLR1 TLR2 TLR4 TLR6 TLR9
31
Show member pathways
12.25 IFNG IL6 TLR1 TLR2 TLR4 TLR6
32 12.22 IFNG IL6 TLR1 TLR2 TLR4 TLR6
33
Show member pathways
12.19 CCL5 FLT4 IFNG IL10 IL2 IL5
34 12.14 IFNG IL2 IL6 TLR4 TNF
35
Show member pathways
12.14 IFNG IL6 TLR1 TLR2 TLR4 TLR6
36 12.13 IFNG IL10 IL2 IL5 IL6 TNF
37
Show member pathways
12.11 IL2 IL5 TLR1 TLR2 TLR4 TLR6
38 12.04 IFNG IL10 IL6 TLR2 TLR4 TNF
39 11.98 IL10 IL6 TNF
40 11.97 TLR1 TLR2 TLR4 TLR6 TLR9
41 11.96 CCL5 IL6 TNF
42 11.96 IFNG IL10 IL2 IL6
43 11.96 CCL5 CTLA4 IFNG IL6 TLR2 TLR4
44 11.94 IFNG IL10 IL2 IL5 TNF
45 11.92 IFNG IL6 TLR4
46 11.92 IFNG IL2 IL5 IL6
47 11.91 IL5 IL6 TNF
48
Show member pathways
11.9 CTLA4 IFNG IL2 IL5 TNF
49 11.89 IL10 IL6 TLR4 TNF
50 11.89 IFNG IL10 IL2 IL6 TLR9 TNF

GO Terms for Filariasis

Cellular components related to Filariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.8 CTLA4 FLT4 TLR1 TLR2 TLR4 TLR6
2 membrane raft GO:0045121 9.62 TLR1 TLR2 TLR6 TNF
3 extracellular space GO:0005615 9.61 ALB CCL5 CHIT1 IFNG IL10 IL2
4 phagocytic vesicle membrane GO:0030670 9.54 TLR1 TLR2 TLR6
5 extracellular region GO:0005576 9.36 ALB CCL5 CHIT1 FLT4 IFNG IL10
6 Toll-like receptor 1-Toll-like receptor 2 protein complex GO:0035354 9.16 TLR1 TLR2

Biological processes related to Filariasis according to GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of DNA-binding transcription factor activity GO:0051091 9.97 IL10 IL5 IL6 TNF
2 response to virus GO:0009615 9.95 CCL5 IFNG TNF
3 positive regulation of JNK cascade GO:0046330 9.95 FLT4 TLR4 TLR9 TNF
4 cellular response to interferon-gamma GO:0071346 9.94 CCL5 TLR2 TLR4
5 defense response to Gram-positive bacterium GO:0050830 9.94 IL6 TLR2 TNF
6 defense response to Gram-negative bacterium GO:0050829 9.94 IL6 TLR4 TLR9
7 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.93 CCL5 IFNG IL2 IL6
8 regulation of insulin secretion GO:0050796 9.92 CCL5 IFNG TNF
9 response to glucocorticoid GO:0051384 9.92 IL10 IL6 TNF
10 I-kappaB kinase/NF-kappaB signaling GO:0007249 9.91 TLR4 TLR9 TNF
11 positive regulation of T cell proliferation GO:0042102 9.91 CCL5 IL2 IL6
12 humoral immune response GO:0006959 9.91 IFNG IL6 TNF
13 positive regulation of smooth muscle cell proliferation GO:0048661 9.9 CCL5 IL6 TNF
14 positive regulation of tumor necrosis factor production GO:0032760 9.9 TLR2 TLR4 TLR9
15 positive regulation of interferon-gamma production GO:0032729 9.89 IL2 TLR4 TNF
16 positive regulation of JUN kinase activity GO:0043507 9.88 TLR6 TLR9 TNF
17 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.88 TLR2 TLR4 TLR9 TNF
18 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.88 IL6 TLR2 TLR4 TLR6 TLR9 TNF
19 positive regulation of nitric oxide biosynthetic process GO:0045429 9.87 IFNG TLR4 TLR6 TNF
20 positive regulation of B cell proliferation GO:0030890 9.86 IL2 IL5 TLR4 TLR9
21 positive regulation of interferon-beta production GO:0032728 9.85 TLR2 TLR4 TLR9
22 lipopolysaccharide-mediated signaling pathway GO:0031663 9.85 CCL5 TLR2 TLR4 TNF
23 positive regulation of inflammatory response GO:0050729 9.85 IL2 TLR2 TLR4 TLR9 TNF
24 positive regulation of JAK-STAT cascade GO:0046427 9.84 CCL5 IL5 IL6
25 positive regulation of interleukin-10 production GO:0032733 9.83 TLR2 TLR4 TLR9
26 microglial cell activation GO:0001774 9.83 TLR2 TLR6 TNF
27 positive regulation of interleukin-6 production GO:0032755 9.83 IL6 TLR2 TLR4 TLR9 TNF
28 positive regulation of macrophage activation GO:0043032 9.82 IL10 TLR4 TLR6
29 regulation of regulatory T cell differentiation GO:0045589 9.81 CTLA4 IFNG IL2
30 negative regulation of interleukin-6 production GO:0032715 9.81 IL10 TLR4 TLR9 TNF
31 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.8 TLR2 TLR4 TLR9
32 cell activation GO:0001775 9.8 TLR1 TLR2 TLR6
33 positive regulation of interleukin-8 production GO:0032757 9.8 TLR2 TLR4 TLR9 TNF
34 I-kappaB phosphorylation GO:0007252 9.79 TLR2 TLR4 TLR9
35 positive regulation of immunoglobulin secretion GO:0051024 9.79 IL2 IL5 IL6
36 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.78 TLR4 TLR6
37 positive regulation of glial cell proliferation GO:0060252 9.78 IL6 TNF
38 response to molecule of bacterial origin GO:0002237 9.78 IL10 TLR2 TLR9
39 positive regulation of interleukin-12 production GO:0032735 9.78 IFNG TLR2 TLR4 TLR9
40 negative regulation of B cell proliferation GO:0030889 9.77 CTLA4 IL10
41 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.77 IFNG TNF
42 negative regulation of growth of symbiont in host GO:0044130 9.77 IL10 TNF
43 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.77 IL10 TNF
44 positive regulation of interleukin-8 secretion GO:2000484 9.77 TLR1 TLR2
45 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.77 TLR4 TLR6
46 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.77 TLR4 TLR9 TNF
47 toll-like receptor signaling pathway GO:0002224 9.77 TLR1 TLR2 TLR4 TLR6 TLR9
48 negative regulation of interleukin-17 production GO:0032700 9.76 IFNG TLR4
49 positive regulation of podosome assembly GO:0071803 9.76 IL5 TNF
50 macrophage activation GO:0042116 9.76 TLR1 TLR4

Molecular functions related to Filariasis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 9.87 ALB CCL5 TLR1 TLR2 TLR4 TLR6
2 signaling receptor activity GO:0038023 9.73 TLR1 TLR2 TLR4 TLR6
3 growth factor activity GO:0008083 9.67 IL10 IL2 IL5 IL6
4 transmembrane signaling receptor activity GO:0004888 9.55 FLT4 TLR1 TLR4 TLR6 TLR9
5 signaling pattern recognition receptor activity GO:0008329 9.46 TLR2 TLR9
6 lipopolysaccharide receptor activity GO:0001875 9.4 TLR2 TLR4
7 Toll-like receptor 2 binding GO:0035663 9.26 TLR1 TLR6
8 cytokine activity GO:0005125 9.17 CCL5 IFNG IL10 IL2 IL5 IL6
9 lipopeptide binding GO:0071723 9.13 TLR1 TLR2 TLR6
10 protein binding GO:0005515 10.32 ALB CCL5 CTLA4 FLT4 IFNG IL10

Sources for Filariasis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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