First-Degree Atrioventricular Block disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: FRS012 MIFTS: 36	First-Degree Atrioventricular Block Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways Drugs Download Expand all tables

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Aliases & Classifications for First-Degree Atrioventricular Block

MalaCards integrated aliases for First-Degree Atrioventricular Block:

Name: First-Degree Atrioventricular Block ¹² ¹⁵

First Degree Atrioventricular Block ⁶ ⁷³

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the circulatory system

Other forms of heart disease

Atrioventricular and left bundle-branch block

Atrioventricular block, first degree

External Ids:

Disease Ontology ¹² DOID:0050821

ICD10 ³³ I44.0

UMLS ⁷³ C0085614

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Summaries for First-Degree Atrioventricular Block

MalaCards based summary : First-Degree Atrioventricular Block, also known as first degree atrioventricular block, is related to progressive familial heart block, type ia and atrial standstill 1. An important gene associated with First-Degree Atrioventricular Block is MYH7 (Myosin Heavy Chain 7), and among its related pathways/superpathways are Gap junction trafficking and Antiarrhythmic Pathway, Pharmacodynamics. The drugs Fingolimod Hydrochloride and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : ⁷⁶ First-degree atrioventricular block (AV block), or PR prolongation, is a disease of the electrical... more...

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Related Diseases for First-Degree Atrioventricular Block

Diseases related to First-Degree Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)

#	Related Disease	Score	Top Affiliating Genes
1	progressive familial heart block, type ia	30.1	GJA5 SCN5A
2	atrial standstill 1	29.4	GJA5 MYH7 SCN5A
3	atrioventricular block	10.7
4	cardiac conduction defect	10.3	MYH7 SCN5A
5	peripartum cardiomyopathy	10.2	MYH7 SCN5A
6	cardiomyopathy, dilated, 1e	10.2	MYH7 SCN5A
7	familial isolated dilated cardiomyopathy	10.2	MYH7 SCN5A
8	atrial standstill	10.1	GJA5 SCN5A
9	progressive familial heart block	10.1	GJA5 SCN5A
10	intrinsic cardiomyopathy	10.1	MYH7 SCN5A
11	atrial fibrillation	10.1
12	heart conduction disease	10.0	GJA5 SCN5A
13	hypotrichosis 6	9.9	DSG4 KRT74
14	hypotrichosis 7	9.9	DSG4 KRT74
15	arteries, anomalies of	9.9
16	supravalvular aortic stenosis	9.9
17	atrioventricular dissociation	9.9
18	fabry disease	9.9
19	coronary artery anomaly	9.9
20	extrapulmonary tuberculosis	9.9
21	left bundle branch hemiblock	9.9
22	endocarditis	9.9
23	cholestasis	9.9
24	intrahepatic cholestasis	9.9
25	syncope	9.9
26	hypotrichosis 8	9.9	DSG4 KRT74
27	oculodentodigital dysplasia	9.7	GJA5 GJC1
28	hair disease	9.7	DSG4 KRT74
29	monilethrix	9.6	DSG4 KRT74
30	familial atrial fibrillation	9.4	GJA5 SCN5A
31	heart disease	9.2	GJA5 MYH7 SCN5A
32	sinoatrial node disease	9.2	GJA5 GJC1 SCN5A

Comorbidity relations with First-Degree Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 44)

Acute Cystitis	Acute Kidney Failure
Anxiety	Aortic Atherosclerosis
Aortic Valve Disease 1	Atrioventricular Block
Benign Essential Hypertension	Bronchitis
Cardiac Arrest	Cardiac Arrhythmia
Chronic Kidney Failure	Chronic Myocardial Ischemia
Deficiency Anemia	Dressler's Syndrome
Esophagitis	Familial Atrial Fibrillation
Generalized Atherosclerosis	Gout
Heart Disease	Hyperlipoproteinemia, Type Iv
Hypertension, Essential	Hypertrophic Cardiomyopathy
Hypoglycemia	Hypothyroidism
Intermediate Coronary Syndrome	Iron Deficiency Anemia
Ischemic Heart Disease	Kidney Disease
Left Bundle Branch Hemiblock	Malignant Essential Hypertension
Mitral Valve Disease	Mobitz Type Ii Atrioventricular Block
Osteoarthritis	Peripheral Vascular Disease
Postinflammatory Pulmonary Fibrosis	Progressive Familial Heart Block, Type Ia
Prostatic Hypertrophy	Pulmonary Hypertension, Primary, 1
Right Bundle Branch Block	Sinoatrial Node Disease
Third-Degree Atrioventricular Block	Transient Cerebral Ischemia
Tricuspid Valve Disease	Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to First-Degree Atrioventricular Block:

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Symptoms & Phenotypes for First-Degree Atrioventricular Block

GenomeRNAi Phenotypes related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

²⁶ (show all 12)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-134	9.5	MYH7
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-139	9.5	DSG4 GJA5 MYH7 SCN5A
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-14	9.5	MYH7
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-184	9.5	MYH7
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-200	9.5	GJA5
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-204	9.5	DSG4
7	Decreased shRNA abundance (Z-score < -2)	GR00366-A-209	9.5	DSG4
8	Decreased shRNA abundance (Z-score < -2)	GR00366-A-211	9.5	GJA5
9	Decreased shRNA abundance (Z-score < -2)	GR00366-A-33	9.5	DSG4
10	Decreased shRNA abundance (Z-score < -2)	GR00366-A-58	9.5	SCN5A
11	Decreased shRNA abundance (Z-score < -2)	GR00366-A-61	9.5	GJA5
12	Decreased shRNA abundance (Z-score < -2)	GR00366-A-62	9.5	GJA5

MGI Mouse Phenotypes related to First-Degree Atrioventricular Block:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.35	GJA5 GJC1 MYH7 SCN5A TSPO
2	muscle	MP:0005369	8.92	GJA5 GJC1 MYH7 SCN5A

Sources

Drugs & Therapeutics for First-Degree Atrioventricular Block

Drugs for First-Degree Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Fingolimod Hydrochloride

Phase 4

Immunosuppressive Agents

Phase 4

Antibodies

Phase 2, Phase 3

Autoantibodies

Phase 2, Phase 3

gamma-Globulins

Phase 2, Phase 3

Immunoglobulins

Phase 2, Phase 3

Immunoglobulins, Intravenous

Phase 2, Phase 3

Rho(D) Immune Globulin

Phase 2, Phase 3

Hydroxychloroquine

Approved

Phase 2

118-42-3

3652

Synonyms:

(+-)-Hydroxychloroquine

(±)-hydroxychloroquine

118-42-3

2-((4-((7-chloro-4-Quinolyl)amino)pentyl)ethylamino)ethanol

2-((4-((7-Chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol

2-(N-(4-(7-Chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol

2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol

2-[4-[(7-chloroquinolin-4-yl)amino]pentyl-ethylamino]ethanol

5-22-10-00280 (Beilstein Handbook Reference)

747-36-4 (sulfate (1:1) salt)

7-chloro-4-(4-(Ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline

7-Chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline

7-chloro-4-(4-(N-Ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline

7-Chloro-4-(4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino)quinoline

7-chloro-4-(4-(N-Ethyl-N-b-hydroxyethylamino)-1-methylbutylamino)quinoline

7-chloro-4-(4-(N-Ethyl-N-β-hydroxyethylamino)-1-methylbutylamino)quinoline

7-Chloro-4-(5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl)aminoquinoline

7-chloro-4-[4-(N-Ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline

7-chloro-4-[4-(N-Ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline

7-chloro-4-[4-(N-Ethyl-N-β-hydroxyethylamino)-1-methylbutylamino]quinoline

7-chloro-4-[5-(N-Ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline

AC1L1GEW

BRN 0253894

C07043

C18H26ClN3O

CHEMBL1535

CID3652

D08050

DB01611

DivK1c_000942

EINECS 204-249-8

Gen-Hydroxychloroquine 200mg Tablets

HCQ

Hidroxicloroquina

Hidroxicloroquina [INN-Spanish]

HMS502P04

Hydroxychlorochin

Hydroxychloroguine

hydroxychloroquine

Hydroxychloroquine (INN)

Hydroxychloroquine [INN:BAN]

Hydroxychloroquine sulfate

Hydroxychloroquine sulfate (1:1) salt

Hydroxychloroquine Sulfate (1:1) Salt

Hydroxychloroquinum

Hydroxychloroquinum [INN-Latin]

IDI1_000942

Idrossiclorochina

Idrossiclorochina [DCIT]

KBio1_000942

LS-66614

MolPort-003-847-792

NCGC00159483-02

NINDS_000942

NSC4375

Oxichlorochine

Oxichlorochinum

Oxichloroquine

Oxychlorochin

Oxychloroquine

PlaqueN/A

Plaquenil

Polirreumin

Polirreumin (TN)

Quensyl

SPBio_001116

Spectrum2_001238

Spectrum5_001697

ST072188

UNII-4QWG6N8QKH

WIN 1258

Emtricitabine

Approved, Investigational

Phase 2

143491-57-0

60877

Synonyms:

(-)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

(−)-(2R,5S)-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

(-)-(2R,5S)-5-fluoro-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

(-)-.beta.-L-FTC

(-)-2',3'-Dideoxy-5-fluoro-3'-thiacytidine

(−)-2'-deoxy-5-fluoro-3'-thiacytidine

(-)-2'-Deoxy-5-fluoro-3'-thiacytidine

(-)-b-2',3'-Dideoxy-5-fluoro-3'-thiacytidine

(-)-beta-2',3'-dideoxy-5-fluoro-3'-thiacytidine

(-)-beta-2',3'-Dideoxy-5-fluoro-3'-thiacytidine

(-)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one

(−)-cis-4-amino-5-fluoro-1-(2-hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one

(-)-cis-4-amino-5-fluoro-1-(2-Hydroxymethyl-1,3-oxathiolan-5-yl)-(1H)-pyrimidin-2-one

(-)-FTC

(−)-FTC

(-)-β-2',3'-dideoxy-5-fluoro-3'-thiacytidine

(−)-β-2',3'-dideoxy-5-fluoro-3'-thiacytidine

(2R-cis)-4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone

(2R-cis)-4-amino-5-fluoro-1-(2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone

(2R-cis)-4-Amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-2(1H)-pyrimidinone

.beta.-L-(-)-(2R,5S)-5-Fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

1-(2-(Hydroxymethyl)oxathiolan-5-yl)-5-fluorocytosine

143491-54-7

143491-57-0

145213-48-5

2',3',5-FTC

2',3'-Dideoxy-5-fluoro-3'-thiacytidine

2'-Deoxy-5-fluoro-3'-oxa-4'-thiocytidine

2'-Deoxy-5-fluoro-3'-thiacytidine

2-FTC

3'-Thia-2'.3'-dideoxy-5-fluorocytidine

4-amino-5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one

4-amino-5-fluoro-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)pyrimidin-2(1H)-one

4-amino-5-fluoro-1-((2R,5S)-2-Hydroxymethyl-[1,3]oxathiolan-5-yl)-1H-pyrimidin-2-one

4-Amino-5-fluoro-1-((2R,5S)-2-hydroxymethyl-[1,3]oxathiolan-5-yl)-1H-pyrimidin-2-one

4-Amino-5-fluoro-1-[(2R,5S)-(hydroxymethyl)-1,3-oxathiolan-5-yl]-2(1H)-pyrimidinone

4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2(1H)-one

4-amino-5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl]pyrimidin-2-one

524W91

5-fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine

5-fluoro-1-((2R,5S)-2-(Hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine

5-Fluoro-1-((2R,5S)-2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine

5-Fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)cytosine

5-fluoro-1-[(2R,5S)-2-(hydroxymethyl)[1,3]oxathiolan-5-yl]cytosine

AC1L1U3I

AC1Q4KUB

beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine

BW 1592

BW 524W91

BW524W91

BW-524W91

C122114

C12599

C8H10FN3O3S

CHEBI:31536

CHEMBL885

CID60877

Coviracil

Coviracil(TM)

D01199

DB00879

dOTFC

DRG-0208

Emtricitabin

Emtricitabina

Emtricitabine

Emtricitabine (JAN/USAN/INN)

Emtricitabinum

Emtriva

Emtriva (TN)

Emtriva(TM)

FT-0080009

HMS2089I05

HSDB 7337

LS-135838

LS-173184

NCGC00164564-01

Racivir

RCV

SBB066061

TL8000958

UNII-G70B4ETF4S

ZINC03629271

Ritonavir

Approved, Investigational

Phase 2

155213-67-5

392622

Synonyms:

1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[[(2S)-3-methyl-2-[[methyl-[(2-propan-2-yl-1,3-thiazol-4-yl)methyl]carbamoyl]amino]butanoyl]amino]-1,6-diphenylhexan-2-yl]carbamate

155213-67-5

1hxw

1sh9

538, ABT

5-Thiazolylmethyl ((alphaS)-alpha-((1S,3S)-1-hydroxy-3-((2S)-2-(3-((2-isopropyl-4-thiazolyl)methyl)-3-methylureido)-3-methylbutyramido)-4-phenylbutyl)phenethyl)carbamate

5-Thiazolylmethyl ((alphaS)-alpha-((1S,3S-1-hydroxy-3-((2S)-2-(3-((2-isopropyl-4-thiazolyl)methyl)-3-methylureido)-3-methylbutyramido)-4-phenylbutyl)phenethyl)carbamate

A-84538

Abbott 84538

ABBOTT-84538

ABT 538

ABT 84538

ABT538

ABT-538

AC1L94GB

AC-733

AKOS000280930

BIDD:GT0387

BIDD:PXR0023

Bio-0093

C07240

C37H48N6O5S2

CHEBI:45409

CHEMBL163

CID392622

CPD000466395

D00427

D019438

DB00503

DRG-0244

FT-0082824

HMS2051B08

HSDB 7160

LS-148860

MLS000759541

MLS001424063

MolPort-000-883-877

N-[(2S,4S,5S)-4-hydroxy-1,6-diphenyl-5-{[(1,3-thiazol-5-ylmethoxy)carbonyl]amino}hexan-2-yl]-N~2~-(methyl{[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl}carbamoyl)-L-valinamide

NCGC00159462-02

Norvir

Norvir (TM)

Norvir (TN)

Norvir Sec

NSC693184

RIT

ritonavir

Ritonavir

Ritonavir (JAN/USAN/INN)

Ritonavir [USAN]

Ritonavir is an inhibitor of HIV protease used to treat HIV infection and AIDS.

Ritonavirum

RTV

S1185_Selleck

SAM001246783

SMR000466395

STK634209

ZINC03944422

Epoetin alfa

Phase 2

113427-24-0

Hematinics

Phase 2

Prolyl-Hydroxylase Inhibitors

Phase 2

Anti-Infective Agents

Phase 2

Antimalarials

Phase 2

Antiparasitic Agents

Phase 2

Antiprotozoal Agents

Phase 2

Antirheumatic Agents

Phase 2

Anti-HIV Agents

Phase 2

Anti-Retroviral Agents

Phase 2

Antiviral Agents

Phase 2

Atazanavir Sulfate

Phase 2

Cytochrome P-450 CYP3A Inhibitors

Phase 2

Cytochrome P-450 Enzyme Inhibitors

Phase 2

HIV Integrase Inhibitors

Phase 2

HIV Protease Inhibitors

Phase 2

Integrase Inhibitors

Phase 2

Nucleic Acid Synthesis Inhibitors

Phase 2

protease inhibitors

Phase 2

Raltegravir Potassium

Phase 2

Reverse Transcriptase Inhibitors

Phase 2

Tenofovir

Phase 2

147127-20-6

464205

Synonyms:

(R)-9-(2-Phosphonomethoxypropyl)adenine

(R)-9-(2-Phosphonylmethoxypropyl)adenine

(R)-PMPA

[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid

147127-20-6

206184-49-8

9-(2-Phosphonomethoxypropyl)adenine

9-(2-Phosphonylmethoxypropyl)adenine

9-(2-Phosphonylmethoxypropyl)adenine, (+-)-isomer

9-(2-Phosphonylmethoxypropyl)adenine, (R)-isomer - T357098

9-(2-Phosphonylmethoxypropyl)adenine, (S)-isomer

9-PMPA (tenofovir)

AC1LA9BO

AC-760

Anh. tenofovir

Anhydrous tenofovir

Apropovir

CHEBI:45809

CHEMBL483

CID464205

D,L-Tenofovir

DB00300

Disoproxil fumarate, tenofovir

Disoproxil, tenofovir

Fumarate, tenofovir disoproxil

GNA & Tenofovir

GS 1275

GS 1278

GS1278

HHA & Tenofovir

KS-5021

MolPort-003-850-411

NCGC00167535-01

Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Galanthus nivalis agglutinin (GNA)

Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- & Hippeastrum hybrid agglutinin( HHA)

Phosphonic acid, [[(1R)-2-(6-amino-9H-purin-9-yl)-1-methylethoxy]methyl]- (9CI)

Phosphonic acid, [[2-(6-amino-9H-purin-9

PMPA

PMPA-(R)

S1401_Selleck

TDF

Tenefovir

Tenofovir

Tenofovir (anh.)

Tenofovir disoproxil

Tenofovir disoproxil fumarate

TFV

UNII-99YXE507IL

Viread

Viread, Tenofovir

Lacosamide

Approved

860352-01-8, 175481-36-4

219078

Synonyms:

( )-(2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide

(2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide

(2R)-2-acetamido-N-benzyl-3-methoxypropanamide

175481-36-4

AC1L560M

ADD 234037

ADD-234037

AKOS005146274

AZD7762

CHEBI:188739

CHEMBL58323

CID219078

D07299

Erlosamide

Erlosamide [INN]

Erlosamide, Vimpat, Lacosamide

Harkoseride

I01-7424

Lacosamide

Lacosamide (USAN/INN)

Lacosamide [USAN]

LS-185541

S1253_Selleck

SPM 927

SPM-927

SPM-929

Vimpat

ZINC00007673

Anticonvulsants

Interventional clinical trials:

(show all 15)

#	Name	Status	NCT ID	Phase	Drugs
1	STudy to vAlidate telemetRic ECG Systems for firsT Dose Administration of Fingolimod (START)	Completed	NCT01585298	Phase 4	FTY720
2	Preventive IVIG Therapy for Congenital Heart Block	Completed	NCT00460928	Phase 2, Phase 3	intravenous immune globulin (IVIG)
3	4 Week Switch Study in Hemodialysis-dependent Subjects With Anemia Associated With Chronic Kidney Disease	Completed	NCT01587924	Phase 2	GSK1278863;rhEPO
4	Preventive Approach to Congenital Heart Block With Hydroxychloroquine	Recruiting	NCT01379573	Phase 2	Hydroxychloroquine
5	Phase IIB Pilot of Atazanavir + Raltegravir	Terminated	NCT00768989	Phase 2	Atazanavir;Raltegravir;Atazanavir;Ritonavir;Tenofovir/Emtricitabine
6	Minimizing Ventricular Pacing	Unknown status	NCT01611389	Not Applicable
7	BiventRicular Pacing in prolongEd Atrio-Ventricular intervaL: the REAL-CRT Study	Unknown status	NCT02150538	Not Applicable
8	Pacing in First-degree AV-block	Completed	NCT01985802	Not Applicable
9	Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR Mode	Completed	NCT02586480
10	Post-Authorization Safety Study to Assess the Safety of Vimpat as add-on Therapy in Patients With Partial-onset Seizures	Completed	NCT00771927		Lacosamide
11	Cardiac Dysfunction in Traumatic Brain Injury	Completed	NCT03566368
12	Comparison Between Standard and Ultrasound Integrated Approach for Risk Stratification of Syncope in the Emergency Department	Recruiting	NCT02781207
13	STIMTAVI : Evolution of Atrioventricular Conduction Disorders After TAVI	Active, not recruiting	NCT03338582
14	Magnesium Effect on Embryonal PR Interval	Not yet recruiting	NCT03047304	Not Applicable
15	Restoration of Atrioventricular Synchrony Trial	Terminated	NCT01275833	Not Applicable

Search NIH Clinical Center for First-Degree Atrioventricular Block

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Genetic Tests for First-Degree Atrioventricular Block

Sources

Anatomical Context for First-Degree Atrioventricular Block

MalaCards organs/tissues related to First-Degree Atrioventricular Block:

⁴¹

Heart, Kidney, Brain

Sources

Publications for First-Degree Atrioventricular Block

Articles related to First-Degree Atrioventricular Block:

(show all 31)

#	Title	Authors	Year
1	Treatment of intrahepatic cholestasis of pregnancy with ursodeoxycholic acid associated with improvement of fetal first-degree atrioventricular block. ( 29484735 )	RodrA-guez M....SepA_lveda-MartA-nez A.	2018
2	Marked First-Degree Atrioventricular Block and Pseudo-Pacemaker Syndrome in a Pediatric Patient. ( 29435607 )	Follansbee C.W....Arora G.	2018
3	Slow pathway modification for treatment of pseudo-pacemaker syndrome due to first-degree atrioventricular block with dual atrioventricular nodal physiology. ( 29707483 )	Lader J.M....Barbhaiya C.R.	2018
4	Symptomatic first-degree atrioventricular block in a young woman after taking a fat burner supplement. ( 29162998 )	Abdelmageed R.E.M....Xiao H.B.	2017
5	Marked Symptomatic Sinus Bradycardia With New Onset First-Degree Atrioventricular Block After Concomitant Methadone and Trazodone Use. ( 28953513 )	Saeed M....Chaudhari S.	2017
6	Pregabalin-induced first degree atrioventricular block in a young patient treated for pain from extrapulmonary tuberculosis. ( 29424197 )	Schiavo A....Cittadini A.	2017
7	First-degree atrioventricular block: risk marker or innocent finding? ( 26936340 )	Aro A.L.	2016
8	Outcomes Related to First-Degree Atrioventricular Block and Therapeutic Implications in Patients With Heart Failure. ( 29766868 )	Nikolaidou T....Clark A.L.	2016
9	First-degree atrioventricular block is associated with advanced atrioventricular block, atrial fibrillation and left ventricular dysfunction in patients with hypertension. ( 24695396 )	Uhm J.S....Lee M.H.	2014
10	First-degree atrioventricular block may not be that benign after all. ( 24695392 )	Bang C.N....Okin P.M.	2014
11	First-degree atrioventricular block is associated with advanced atrioventricular block, atrial fibrillation and left ventricular dysfunction in patients with hypertension. ( 24509124 )	Uhm J.S....Lee M.H.	2014
12	Association of WPW syndrome and first-degree atrioventricular block : Electrocardiographic diagnosis. ( 23873008 )	Zhang Y....Chen Y.	2014
13	Marked First Degree Atrioventricular Block: an extremely prolonged PR interval associated with Atrioventricular Dissociation in a young Nigerian man with Pseudo-Pacemaker Syndrome: a case report. ( 25371009 )	Ogunlade O....Eluwole O.A.	2014
14	First-degree atrioventricular block and pseudopacemaker syndrome. ( 23791585 )	Laurent G....Wolf J.E.	2013
15	Short- and long-term outcomes depending on electrical dyssynchrony markers in patients presenting with acute heart failure: clinical implication of the first-degree atrioventricular block and QRS prolongation from the Korean Heart Failure registry. ( 23237134 )	Park S.J....Jeon E.S.	2013
16	Coronary Artery to Right Atrium Fistula Associated With First Degree Atrioventricular Block: A Rare Association. ( 26316663 )	Wong R.C....Yip J.W.	2013
17	Profound first-degree atrioventricular block. ( 24057329 )	Akhtar W....Farooqi F.	2013
18	Atazanavir induced first degree atrioventricular block and ventricular tachycardia: a case report. ( 23691707 )	Santimaleeworagun W....Chayagul P.	2013
19	Significance of first-degree atrioventricular block in acute endocarditis. ( 23440164 )	Atallah P.C.	2013
20	Conventional and biventricular pacing in patients with first-degree atrioventricular block. ( 22516061 )	Barold S.S....Herweg B.	2012
21	First-degree atrioventricular block is associated with heart failure and death in persons with stable coronary artery disease: data from the Heart and Soul Study. ( 21606074 )	Crisel R.K....Whooley M.A.	2011
22	Second diastolic pulmonary venous flow and isolated late diastolic mitral valve regurgitation in first-degree atrioventricular block. ( 19933289 )	Leibundgut G....Bernheim A.M.	2010
23	Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block. ( 19549974 )	Cheng S....Wang T.J.	2009
24	Reversal of first-degree atrioventricular block in Fabry disease. ( 19901148 )	Blum A....Khasin M.	2009
25	Outcomes in patients with prolonged PR interval or first-degree atrioventricular block. ( 19903913 )	Oh J....Kang S.M.	2009
26	Outcomes in patients with prolonged PR interval or first-degree atrioventricular block. ( 19903912 )	Doraiswamy V.A.	2009
27	Prevention of complete heart block in children of mothers with anti-SSA/Ro and anti-SSB/La autoantibodies: detection and treatment of first-degree atrioventricular block. ( 19584727 )	Mevorach D....Rein A.J.	2009
28	Ecg of the month. Unusual electrocardiogram 42 years after operation for supravalvular aortic stenosis and 6 years after aortic valve replacement. Sinus rhythm with first degree atrioventricular block. ( 18681350 )	Glancy D.L....Heck H.A.	2008
29	Transient syncope, left bundle branch block and first degree atrioventricular block after &quot;pill-in-the-pocket&quot; administration. ( 17408787 )	PatanA" S....Di Bella G.	2008
30	First-degree atrioventricular block. Clinical manifestations, indications for pacing, pacemaker management &amp; consequences during cardiac resynchronization. ( 17334913 )	Barold S.S....Herweg B.	2006
31	First-degree atrioventricular block in alprazolam overdose reversed by flumazenil. ( 10344640 )	Mullins M.E.	1999

Sources

Genes for First-Degree Atrioventricular Block

Genes related to First-Degree Atrioventricular Block (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MYH7	Myosin Heavy Chain 7	Protein Coding	18.26	GeneCards inferred via : Variants (show sections)
2	TSPO	Translocator Protein	Protein Coding	17.33	GeneCards inferred via : Publications (show sections)
3	SCN5A	Sodium Voltage-Gated Channel Alpha Subunit 5	Protein Coding	15.6	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	GJA5	Gap Junction Protein Alpha 5	Protein Coding	15.53	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	DSG4	Desmoglein 4	Protein Coding	15.18	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	GJC1	Gap Junction Protein Gamma 1	Protein Coding	15.04	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	KRT74	Keratin 74	Protein Coding	14.88	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

Sources

Variations for First-Degree Atrioventricular Block

ClinVar genetic disease variations for First-Degree Atrioventricular Block:

⁶

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	MYH7	NM_000257.3(MYH7): c.4717G> A (p.Glu1573Lys)	single nucleotide variant	Uncertain significance	rs750987717	GRCh37	Chromosome 14, 23885449: 23885449
2	MYH7	NM_000257.3(MYH7): c.4717G> A (p.Glu1573Lys)	single nucleotide variant	Uncertain significance	rs750987717	GRCh38	Chromosome 14, 23416240: 23416240

Sources

Expression for First-Degree Atrioventricular Block

Search GEO for disease gene expression data for First-Degree Atrioventricular Block.

Sources

Pathways for First-Degree Atrioventricular Block

Pathways related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Gap junction trafficking ⁶⁶ Show member pathways Entry of Influenza Virion into Host Cell via Endocytosis ⁶⁶ Formation of annular gap junctions ⁶⁶ Gap junction assembly ⁶⁶ Gap junction degradation ⁶⁶ Gap junction trafficking and regulation ⁶⁶	10.95	GJA5 GJC1
2	Antiarrhythmic Pathway, Pharmacodynamics ⁶¹	10.37	GJA5 SCN5A

Sources

GO Terms for First-Degree Atrioventricular Block

Cellular components related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	gap junction	GO:0005921	9.16	GJA5 GJC1
2	connexin complex	GO:0005922	8.96	GJA5 GJC1
3	intercalated disc	GO:0014704	8.8	GJA5 GJC1 SCN5A

Biological processes related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	cornification	GO:0070268	9.57	DSG4 KRT74
2	muscle contraction	GO:0006936	9.56	GJC1 MYH7
3	cell communication	GO:0007154	9.55	GJA5 GJC1
4	cardiac conduction	GO:0061337	9.54	GJA5 SCN5A
5	cardiac muscle contraction	GO:0060048	9.52	MYH7 SCN5A
6	regulation of heart rate by cardiac conduction	GO:0086091	9.51	GJA5 SCN5A
7	regulation of heart rate	GO:0002027	9.49	MYH7 SCN5A
8	regulation of ventricular cardiac muscle cell membrane repolarization	GO:0060307	9.48	GJA5 SCN5A
9	ventricular cardiac muscle cell action potential	GO:0086005	9.46	GJA5 SCN5A
10	regulation of atrial cardiac muscle cell membrane depolarization	GO:0060371	9.43	GJA5 SCN5A
11	atrial cardiac muscle cell action potential	GO:0086014	9.4	GJC1 SCN5A
12	regulation of ventricular cardiac muscle cell membrane depolarization	GO:0060373	9.37	GJA5 SCN5A
13	gap junction assembly	GO:0016264	9.32	GJA5 GJC1
14	SA node cell action potential	GO:0086015	9.26	GJA5 SCN5A
15	AV node cell to bundle of His cell communication	GO:0086067	9.16	GJA5 SCN5A
16	AV node cell to bundle of His cell communication by electrical coupling	GO:0086053	8.96	GJA5 GJC1
17	SA node cell to atrial cardiac muscle cell communication by electrical coupling	GO:0086021	8.62	GJA5 GJC1

Molecular functions related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	ion channel binding	GO:0044325	9.26	SCN5A TSPO
2	gap junction channel activity	GO:0005243	9.16	GJA5 GJC1
3	gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling	GO:0086077	8.96	GJA5 GJC1
4	gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling	GO:0086020	8.62	GJA5 GJC1

Sources

Sources for First-Degree Atrioventricular Block

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia