Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Datasets Our Publications Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: FRS012
MIFTS: 38

First-Degree Atrioventricular Block

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways
Sources

Aliases & Classifications for First-Degree Atrioventricular Block

About this section

MalaCards integrated aliases for First-Degree Atrioventricular Block:

Name: First-Degree Atrioventricular Block 12 15
First Degree Atrioventricular Block 6 71

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0050821
ICD10 32 I44.0
UMLS 71 C0085614
Sources

Summaries for First-Degree Atrioventricular Block

About this section
Disease Ontology : 12 An atrioventricular block that is characterized by prolonged PR interval on electrocardiogram caused by delayed conduction from atria to ventricles through the atrioventricular node.

MalaCards based summary : First-Degree Atrioventricular Block, also known as first degree atrioventricular block, is related to atrioventricular block and cardiac conduction defect. An important gene associated with First-Degree Atrioventricular Block is MYH7 (Myosin Heavy Chain 7), and among its related pathways/superpathways are Dilated cardiomyopathy (DCM) and Antiarrhythmic Pathway, Pharmacodynamics. Affiliated tissues include heart, atrioventricular node and testes, and related phenotype is cardiovascular system.

Wikipedia : 74 First-degree atrioventricular block (AV block) is a disease of the electrical conduction system of the... more...

Sources

Related Diseases for First-Degree Atrioventricular Block

About this section

Diseases related to First-Degree Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 atrioventricular block 30.6 SCN5A NPPB MYH7 MHRT LMNA ACE
2 cardiac conduction defect 30.5 SCN5A MYH7 LMNA
3 mitral valve insufficiency 30.4 NPPB CRP ACE
4 sick sinus syndrome 30.0 SCN5A LMNA KCNJ2
5 aortic valve insufficiency 30.0 NPPB CRP ACE
6 heart valve disease 30.0 NPPB CRP ACE
7 cardiac arrest 29.8 SCN5A NPPB MYH7 ACE
8 left bundle branch hemiblock 29.8 SCN5A NPPB LMNA CRP ACE
9 brugada syndrome 29.7 SCN5A MYH7 LMNA KCNJ2
10 lipoprotein quantitative trait locus 29.7 SCN5A NPPB CRP ACE
11 right bundle branch block 29.6 SCN5A NPPB DSG4 ACE
12 atrial standstill 1 29.3 SCN5A NPPB MYH7 LMNA EMD ACE
13 congestive heart failure 28.4 SCN5A NPPB MYH7 LMNA KCNJ2 CRP
14 hypertrophic cardiomyopathy 28.2 SCN5A NPPB MYH7 MHRT LMNA KCNJ2
15 atrial fibrillation 27.6 SCN5A NPPB MYH7 LMNA KCNJ2 EMD
16 dilated cardiomyopathy 27.3 SCN5A NPPB MYH7 MHRT LMNA KCNJ2
17 heart disease 27.3 SCN5A NPPB MYH7 MHRT LMNA KCNJ2
18 syncope 10.5
19 progressive familial heart block, type ia 10.4
20 scapuloperoneal myopathy 10.4 MYH7 MHRT
21 mediastinum teratoma 10.3 CRP ACE
22 acute dacryoadenitis 10.3 CRP ACE
23 acute stress disorder 10.3 MHRT CRP
24 posterior scleritis 10.3 CRP ACE
25 tolosa-hunt syndrome 10.3 CRP ACE
26 multiple cranial nerve palsy 10.3 CRP ACE
27 cranial nerve palsy 10.3 CRP ACE
28 granulomatous angiitis 10.3 CRP ACE
29 neuroretinitis 10.3 CRP ACE
30 silent myocardial infarction 10.3 CRP ACE
31 cholesterol embolism 10.3 CRP ACE
32 optic papillitis 10.3 CRP ACE
33 generalized atherosclerosis 10.3 CRP ACE
34 intracranial embolism 10.3 CRP ACE
35 cat-scratch disease 10.3 CRP ACE
36 melancholia 10.3 MHRT CRP
37 cardiomyopathy, dilated, 1b 10.3 SCN5A MYH7 LMNA
38 neurosarcoidosis 10.3 CRP ACE
39 hypertensive retinopathy 10.3 CRP ACE
40 scleral disease 10.3 CRP ACE
41 second-degree atrioventricular block 10.3 TRIM44 SCN5A
42 cardiomyopathy, dilated, 1e 10.3 SCN5A MYH7 LMNA
43 emerinopathy 10.3 LMNA EMD
44 iritis 10.3 CRP ACE
45 background diabetic retinopathy 10.3 CRP ACE
46 iridocyclitis 10.2 CRP ACE
47 x-linked emery-dreifuss muscular dystrophy 10.2 LMNA EMD
48 cardiogenic shock 10.2 NPPB CRP
49 chronic thromboembolic pulmonary hypertension 10.2 NPPB CRP
50 peripartum cardiomyopathy 10.2 SCN5A MYH7 ACE

Comorbidity relations with First-Degree Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 41)


Acute Cystitis Acute Kidney Failure
Anxiety Aortic Atherosclerosis
Aortic Valve Disease 1 Atrioventricular Block
Benign Essential Hypertension Bronchitis
Cardiac Arrest Cardiac Arrhythmia
Deficiency Anemia Dressler's Syndrome
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Gout
Heart Disease Hyperlipoproteinemia, Type Iv
Hypertension, Essential Hypertrophic Cardiomyopathy
Hypoglycemia Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Kidney Disease Left Bundle Branch Hemiblock
Malignant Essential Hypertension Mitral Valve Disease
Mobitz Type Ii Atrioventricular Block Osteoarthritis
Peripheral Vascular Disease Postinflammatory Pulmonary Fibrosis
Progressive Familial Heart Block, Type Ia Prostatic Hypertrophy
Pulmonary Hypertension, Primary, 1 Right Bundle Branch Block
Sinoatrial Node Disease Third-Degree Atrioventricular Block
Transient Cerebral Ischemia Tricuspid Valve Disease
Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to First-Degree Atrioventricular Block:



Diseases related to First-Degree Atrioventricular Block
Sources

Symptoms & Phenotypes for First-Degree Atrioventricular Block

About this section

MGI Mouse Phenotypes related to First-Degree Atrioventricular Block:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.28 ACE CRP DMPK EMD KCNJ2 LMNA
Sources

Drugs & Therapeutics for First-Degree Atrioventricular Block

About this section

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Minimizing Right Ventricular Pacing in Dual-chamber Pacemaker Patients With Sinus Node Disease and First Degree Atrioventricular Block. Unknown status NCT01611389
2 BiventRicular Pacing in prolongEd Atrio-Ventricular intervaL: the REAL-CRT Study Unknown status NCT02150538
3 Cohort Description of Younger With AV-block Unknown status NCT03024047
4 Restoration of Atrioventricular Coupling by Cardiac Resynchronization Therapy in Heart Failure Patients With Prolonged PR Interval Recruiting NCT03973944

Search NIH Clinical Center for First-Degree Atrioventricular Block

Sources

Genetic Tests for First-Degree Atrioventricular Block

About this section
Sources

Anatomical Context for First-Degree Atrioventricular Block

About this section

MalaCards organs/tissues related to First-Degree Atrioventricular Block:

40
Heart, Atrioventricular Node, Testes, Bone Marrow, Bone, Thyroid, B Cells
Sources

Publications for First-Degree Atrioventricular Block

About this section

Articles related to First-Degree Atrioventricular Block:

(show top 50) (show all 380)
# Title Authors PMID Year
1
Narrow QRS tachycardia in a patient with first degree atrioventricular block: What is the mechanism? 61
32573784 2020
2
"Preventive" pacing in patients with tachy-brady syndrome (TBS): Confirming a common practice. 61
32533880 2020
3
Clinical predictors of all-cause mortality in patients presenting to specialist heart failure clinic with raised NT-proBNP and no heart failure. 61
32496010 2020
4
Interactive effects of mercury exposure and hypoxia on ECG patterns in two Neotropical freshwater fish species: Matrinxã, Brycon amazonicus and traíra, Hoplias malabaricus. 61
32166694 2020
5
Predictors, incidence, and prognostic significance of PR interval prolongation in patients with ST-segment elevation myocardial infarction. 61
32404593 2020
6
A case of complete atrioventricular block in secondary hemophagocytic syndrome/hemophagocytic lymphohistiocytosis recovered by plasma exchange and cytokine absorbing therapy with AN69ST continuous hemodiafiltration. 61
32374660 2020
7
Prognostic Implication of First-Degree Atrioventricular Block in Patients With Hypertrophic Cardiomyopathy. 61
32146896 2020
8
First-Degree Atrioventricular Block and Hypertrophic Cardiomyopathy: "I Have a Bad Feeling About This". 61
32146897 2020
9
Impact of the repositionable Evolut R CoreValve system on the need for a permanent pacemaker after transcatheter aortic valve implantation in patients with severe aortic stenosis. 61
31062927 2020
10
Risk Prediction Model for Cardiac Implantable Electronic Device Implantation After Transcatheter Aortic Valve Replacement. 61
32192680 2020
11
Cardioembolic acute cerebral micro-infarcts in the context of atrial fibrillation after low-dose intravenous infusion of lacosamide. 61
32043469 2020
12
Electrocardiography Interpretation Competency of Medical Interns: Experience from Two Ethiopian Medical Schools. 61
32455024 2020
13
Long-Term Electrocardiographic Changes and Clinical Outcomes of Transcatheter Aortic Valve Implantation Recipients Without New Postprocedural Conduction Disturbances. 61
31732136 2020
14
Analysis of cardiac monitoring and safety data in patients initiating fingolimod treatment in the home or in clinic. 61
31729968 2019
15
Pharmacokinetics and Safety of Posaconazole Administered by Intravenous Solution and Oral Tablet in Healthy Chinese Subjects and Effect of Food on Tablet Bioavailability. 61
31432392 2019
16
Prevalence of first-degree atrioventricular block and the associated risk factors: a cross-sectional study in rural Northeast China. 61
31590630 2019
17
One-Year Follow-Up of Conduction Abnormalities After Transcatheter Aortic Valve Implantation With the SAPIEN 3 Valve. 61
31439281 2019
18
Pacemaker implantation in familial amyloid polyneuropathy: when and for whom? 61
30852744 2019
19
Association between PR Interval, First-degree atrioventricular block and major arrhythmic events in patients with Brugada syndrome - Systematic review and meta-analysis. 61
31410227 2019
20
Arrhythmias and Adaptations of the Cardiac Conduction System in Former National Football League Players. 61
31337251 2019
21
Familial Clustering of Cardiac Conduction Defects and Pacemaker Insertion. 61
31216886 2019
22
Transient left anterior and septal fascicular blocks after self-expandable percutaneous transcatheter aortic valve implantation. 61
29675905 2019
23
HYPERTENSIVE HEART DISEASE AND ENCEPHALOPATHY IN A CENTRAL BEARDED DRAGON (POGONA VITTICEPS) WITH SEVERE ATHEROSCLEROSIS AND FIRST-DEGREE ATRIOVENTRICULAR BLOCK. 61
31260220 2019
24
Cardiac disease in mucopolysaccharidosis type III. 61
30671988 2019
25
Occurrence of significant long PR intervals in patients implanted for sinus node dysfunction and monitored with SafeR™: The PRECISE study. 61
30594571 2019
26
First-degree atrioventricular block on basal electrocardiogram predicts future arrhythmic events in patients with Brugada syndrome: a long-term follow-up study from the Veneto region of Northeastern Italy. 61
29986018 2019
27
Syncope due to acute rheumatic fever with pacemaker-like syndrome. 61
32105019 2019
28
Sudden cardiac death: the finish line as a beginning: a true endurance race in a case report. 61
31020196 2018
29
Association between decreasing estimated glomerular filtration rate and risk of cardiac conduction defects in patients with type 2 diabetes. 61
30195089 2018
30
Cisplatin-induced cardiotoxicity with midrange ejection fraction: A case report and review of the literature. 61
30593170 2018
31
Treatment of intrahepatic cholestasis of pregnancy with ursodeoxycholic acid associated with improvement of fetal first-degree atrioventricular block. 61
29484735 2018
32
Lithium intoxication presenting as altered consciousness and arrhythmia with cardiogenic shock: A case report. 61
30407335 2018
33
Woman with recurrent vomiting. 61
30337419 2018
34
Syncope due to complete atrioventricular block and treatment with a transient pacemaker in acute rheumatic fever. 61
30459521 2018
35
Marked Symptomatic Sinus Bradycardia With New Onset First-Degree Atrioventricular Block After Concomitant Methadone and Trazodone Use. 61
28953513 2018
36
Low-energy ablation of anteroseptal accessory pathways in two dogs. 61
29859723 2018
37
Safety of ticagrelor in patients with baseline conduction abnormalities: A PLATO (Study of Platelet Inhibition and Patient Outcomes) analysis. 61
29859968 2018
38
Severe brady-arrhythmias in systemic lupus erythematosus: prevalence, etiology and associated factors. 61
29665757 2018
39
Electrocardiographic abnormalities in Chagas disease in the general population: A systematic review and meta-analysis. 61
29897909 2018
40
Development and Validation of a New Scoring System to Predict Survival in Patients With Myotonic Dystrophy Type 1. 61
29404559 2018
41
Electrocardiographic patterns and long-term training-induced time changes in 2484 elite football players. 61
29275944 2018
42
A case of cardiac sarcoidosis mimicking cardiac amyloidosis on cardiovascular magnetic resonance. 61
29405655 2018
43
ECG Predictors of Cardiac Arrhythmias in Older Adults With Syncope. 61
29275946 2018
44
Recurrent extensive anterior myocardial infarction with left and right bundle branch block. 61
29034539 2018
45
Slow pathway modification for treatment of pseudo-pacemaker syndrome due to first-degree atrioventricular block with dual atrioventricular nodal physiology. 61
29707483 2018
46
Marked First-Degree Atrioventricular Block and Pseudo-Pacemaker Syndrome in a Pediatric Patient. 61
29435607 2018
47
Exercise induced complete atrioventricular block: Utility of exercise stress test. 61
29042058 2018
48
Chagasic cardiomyopathy and Pompe disease: case report. 61
29755837 2018
49
Severe cardiac toxicity following alcohol intake in a patient using therapeutic dose of propafenone. 61
29226898 2017
50
Symptomatic first-degree atrioventricular block in a young woman after taking a fat burner supplement. 61
29162998 2017
Sources

Variations for First-Degree Atrioventricular Block

About this section

ClinVar genetic disease variations for First-Degree Atrioventricular Block:

6 ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 MYH7 NM_000257.4(MYH7):c.4717G>A (p.Glu1573Lys)SNV Uncertain significance 222729 rs750987717 14:23885449-23885449 14:23416240-23416240
Sources

Expression for First-Degree Atrioventricular Block

About this section
Search GEO for disease gene expression data for First-Degree Atrioventricular Block.
Sources

Pathways for First-Degree Atrioventricular Block

About this section

Pathways related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Dilated cardiomyopathy (DCM) 36
Show member pathways
 11.19 MYH7 LMNA EMD ACE
2
Antiarrhythmic Pathway, Pharmacodynamics 60
10.88 SCN5A LMNA KCNJ2
3
Cardiomyocyte Differentiation through BMP Receptors 63
10.5 NPPB MYH7
Sources

GO Terms for First-Degree Atrioventricular Block

About this section

Biological processes related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of blood vessel diameter GO:0097746 9.37 NPPB ACE
2 nuclear envelope organization GO:0006998 9.32 LMNA DMPK
3 cardiac muscle cell action potential involved in contraction GO:0086002 9.26 SCN5A KCNJ2
4 regulation of cardiac muscle cell contraction GO:0086004 9.16 SCN5A KCNJ2
5 membrane depolarization during cardiac muscle cell action potential GO:0086012 8.96 SCN5A KCNJ2
6 mitotic nuclear envelope reassembly GO:0007084 8.62 LMNA EMD
Sources

Sources for First-Degree Atrioventricular Block

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....