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MCID: FRS012
MIFTS: 39

First-Degree Atrioventricular Block

Categories: Cardiovascular diseases
Genes Variations Tissues Related diseases Publications Pathways
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Aliases & Classifications for First-Degree Atrioventricular Block

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MalaCards integrated aliases for First-Degree Atrioventricular Block:

Name: First-Degree Atrioventricular Block 12 15
First Degree Atrioventricular Block 6 70

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases
See all MalaCards categories (disease lists)
ICD10: 32


External Ids:

Disease Ontology 12 DOID:0050821
ICD10 32 I44.0
UMLS 70 C0085614
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Summaries for First-Degree Atrioventricular Block

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Disease Ontology : 12 An atrioventricular block that is characterized by prolonged PR interval on electrocardiogram caused by delayed conduction from atria to ventricles through the atrioventricular node.

MalaCards based summary : First-Degree Atrioventricular Block, also known as first degree atrioventricular block, is related to syncope and cardiac conduction defect. An important gene associated with First-Degree Atrioventricular Block is MYH7 (Myosin Heavy Chain 7), and among its related pathways/superpathways are Dilated cardiomyopathy and Antiarrhythmic Pathway, Pharmacodynamics. Affiliated tissues include heart, atrioventricular node and bone marrow, and related phenotypes are cardiovascular system and muscle

Wikipedia : 73 First-degree atrioventricular block (AV block) is a disease of the electrical conduction system of the... more...

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Related Diseases for First-Degree Atrioventricular Block

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Diseases related to First-Degree Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 213)
# Related Disease Score Top Affiliating Genes
1 syncope 30.8 SCN5A KCNH2
2 cardiac conduction defect 30.4 SCN5A MYH7 LMNA
3 inferior myocardial infarction 30.4 NPPB ACE
4 mitral valve insufficiency 30.3 NPPB MYH7 CRP ACE
5 atrioventricular block 30.2 TRIM21 SCN5A NPPB MYH7 MHRT LMNA
6 aortic valve insufficiency 30.1 NPPB CRP ACE
7 heart valve disease 30.1 NPPB CRP ACE
8 left bundle branch hemiblock 30.0 SCN5A NPPB LMNA CRP ACE
9 congestive heart failure 30.0 SCN5A NPPB MYH7 CRP ACE
10 right bundle branch block 29.8 SCN5A NPPB KCNH2 ACE
11 brugada syndrome 29.7 SCN5A MYH7 LMNA KCNJ2 KCNH2
12 myocardial infarction 29.7 SCN5A NPPB MYH7 CRP ACE
13 atrial standstill 1 29.6 SCN5A NPPB MYH7 MHRT LMNA EMD
14 cardiac arrest 29.6 SCN5A NPPB MYH7 KCNH2 ACE
15 atrial fibrillation 28.9 SCN5A NPPB MYH7 LMNA KCNJ2 KCNH2
16 lipoprotein quantitative trait locus 28.6 SCN5A NPPB MYH7 LMNA KCNJ2 KCNH2
17 heart disease 28.3 SCN5A NPPB MYH7 MHRT LMNA KCNJ2
18 hypertrophic cardiomyopathy 28.0 SCN5A NPPB MYH7 MHRT LMNA KCNJ2
19 dilated cardiomyopathy 28.0 SCN5A NPPB MYH7 MHRT LMNA KCNJ2
20 progressive familial heart block, type ia 10.4
21 autosomal dominant distal myopathy 10.4 MYH7 MHRT
22 acute dacryoadenitis 10.3 CRP ACE
23 mediastinum teratoma 10.3 CRP ACE
24 lateral myocardial infarction 10.3 SCN5A ACE
25 anterior scleritis 10.3 CRP ACE
26 multiple cranial nerve palsy 10.3 CRP ACE
27 cranial nerve palsy 10.3 CRP ACE
28 posterior scleritis 10.3 CRP ACE
29 mitochondrial dna depletion syndrome 12b 10.3 SCN5A MYH7
30 tolosa-hunt syndrome 10.3 CRP ACE
31 chronic orbital inflammation 10.3 CRP ACE
32 silent myocardial infarction 10.3 CRP ACE
33 glossopharyngeal nerve disease 10.3 CRP ACE
34 granulomatous angiitis 10.3 CRP ACE
35 urinary tract infection 10.3 CRP ACE
36 neuroretinitis 10.3 CRP ACE
37 cholesterol embolism 10.3 CRP ACE
38 optic papillitis 10.3 CRP ACE
39 granulomatous hepatitis 10.3 CRP ACE
40 brugada syndrome 5 10.3 SCN5A LMNA
41 generalized atherosclerosis 10.3 CRP ACE
42 intracranial embolism 10.3 CRP ACE
43 cat-scratch disease 10.3 CRP ACE
44 neurosarcoidosis 10.2 CRP ACE
45 hypertensive retinopathy 10.2 CRP ACE
46 emerinopathy 10.2 LMNA EMD
47 second-degree atrioventricular block 10.2 TRIM21 SCN5A
48 heart aneurysm 10.2 CRP ACE
49 bartonellosis 10.2 CRP ACE
50 scapuloperoneal myopathy 10.2 MYH7 MHRT

Comorbidity relations with First-Degree Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 42)


Acute Cystitis Acute Kidney Failure
Anxiety Aortic Atherosclerosis
Aortic Valve Disease 1 Atrioventricular Block
Benign Essential Hypertension Bronchitis
Cardiac Arrest Cardiac Arrhythmia
Chronic Kidney Disease Deficiency Anemia
Dressler's Syndrome Esophagitis
Familial Atrial Fibrillation Generalized Atherosclerosis
Gout Heart Disease
Hyperlipoproteinemia, Type Iv Hypertension, Essential
Hypertrophic Cardiomyopathy Hypoglycemia
Hypothyroidism Intermediate Coronary Syndrome
Iron Deficiency Anemia Kidney Disease
Left Bundle Branch Hemiblock Malignant Essential Hypertension
Mitral Valve Disease Mobitz Type Ii Atrioventricular Block
Osteoarthritis Peripheral Vascular Disease
Postinflammatory Pulmonary Fibrosis Progressive Familial Heart Block, Type Ia
Prostatic Hypertrophy Pulmonary Hypertension, Primary, 1
Right Bundle Branch Block Sinoatrial Node Disease
Third-Degree Atrioventricular Block Transient Cerebral Ischemia
Tricuspid Valve Disease Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to First-Degree Atrioventricular Block:



Diseases related to First-Degree Atrioventricular Block
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Symptoms & Phenotypes for First-Degree Atrioventricular Block

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MGI Mouse Phenotypes related to First-Degree Atrioventricular Block:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.65 ACE CRP DMPK EMD KCNH2 KCNJ2
2 muscle MP:0005369 9.17 DMPK EMD KCNH2 KCNJ2 LMNA MYH7
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Drugs & Therapeutics for First-Degree Atrioventricular Block

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Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 BiventRicular Pacing in prolongEd Atrio-Ventricular intervaL: the REAL-CRT Study Unknown status NCT02150538
2 Minimizing Right Ventricular Pacing in Dual-chamber Pacemaker Patients With Sinus Node Disease and First Degree Atrioventricular Block. Unknown status NCT01611389

Search NIH Clinical Center for First-Degree Atrioventricular Block

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Genetic Tests for First-Degree Atrioventricular Block

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Anatomical Context for First-Degree Atrioventricular Block

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MalaCards organs/tissues related to First-Degree Atrioventricular Block:

40
Heart, Atrioventricular Node, Bone Marrow, Cervix, Bone
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Publications for First-Degree Atrioventricular Block

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Articles related to First-Degree Atrioventricular Block:

(show top 50) (show all 404)
# Title Authors PMID Year
1
Cardiac conduction abnormalities in patients with degenerated bioprostheses undergoing transcatheter aortic valve-in-valve implantations and their impact on long-term outcomes. 61
33592238 2021
2
BASCULE syndrome associated with presyncopal episodes and first-degree atrioventricular block. 61
33797752 2021
3
Pathological findings of myocardium in a patient with cardiac conduction defect associated with an SCN5A mutation. 61
33651170 2021
4
Predictors of pacemaker implantation after transcatheter aortic valve implantation according to kind of prosthesis and risk profile: a systematic review and contemporary meta-analysis. 61
33289527 2021
5
Long-term Electrocardiographic Follow-up in Patients with Light-chain Cardiac Amyloidosis. 61
33692307 2021
6
First-degree atrioventricular block is significantly associated with incident atrial fibrillation in the population predominantly including participants aged ≥ 60 years. 61
33595701 2021
7
The Harder the Heart, the Harder It Breaks: A Case of Complete Atrioventricular Block Secondary to Tertiary Hyperparathyroidism. 61
33728211 2021
8
Complete atrioventricular block and permanent pacemaker implantation following percutaneous coronary intervention to left anterior descending artery chronic total occlusion. 61
33514488 2021
9
Progressive First-Degree Atrioventricular Block as a Warning Sign for Perioperative Bradyarrhythmia. 61
33129641 2021
10
A case of complete atrioventricular block in secondary hemophagocytic syndrome/hemophagocytic lymphohistiocytosis recovered by plasma exchange and cytokine absorbing therapy with AN69ST continuous hemodiafiltration. 61
32374660 2020
11
Exacerbation of atrioventricular block associated with concomitant use of amlodipine and aprepitant in a lung cancer patient: A case report. 61
33355084 2020
12
Risk factors for permanent pacemaker implantation in patients receiving a balloon-expandable transcatheter aortic valve prosthesis. 61
32591894 2020
13
MIS-C and Cardiac Conduction Abnormalities. 61
33184170 2020
14
Predictors, incidence, and prognostic significance of PR interval prolongation in patients with ST-segment elevation myocardial infarction. 61
32404593 2020
15
Immune-Mediated Fetal Complete Atrioventricular Block: Can Dexamethasone Therapy Revert the Process? 61
33249793 2020
16
Atrioventricular Block in Children With Multisystem Inflammatory Syndrome. 61
32855347 2020
17
Electrocardiographic Findings in Bitches Affected by Closed Cervix Pyometra. 61
33233788 2020
18
First-degree atrioventricular block in acute anterior myocardial infarction. 61
33115257 2020
19
Electrocardiographic interpretation in athletes. 61
33059398 2020
20
Impact of baseline conduction abnormalities on outcomes after transcatheter aortic valve replacement with SAPIEN-3. 61
33010100 2020
21
"Preventive" pacing in patients with tachy-brady syndrome (TBS): Confirming a common practice. 61
32533880 2020
22
Cryoablation with an 8-mm tip catheter for typical AVNRT in children: a single center 5-year experience. 61
32968865 2020
23
Prolonged Continuous Electrocardiographic Monitoring Prior to Transcatheter Aortic Valve Replacement: The PARE Study. 61
32682674 2020
24
Narrow QRS tachycardia in a patient with first-degree atrioventricular block: What is the mechanism? 61
32573784 2020
25
Clinical predictors of all-cause mortality in patients presenting to specialist heart failure clinic with raised NT-proBNP and no heart failure. 61
32496010 2020
26
Dexmedetomidine infusion for sedation in a patient with myotonic dystrophy. 61
33210091 2020
27
First-degree atrioventricular block in patients with atrial fibrillation and atrial flutter: the prevalence of intra-atrial conduction delay. 61
32734408 2020
28
Interactive effects of mercury exposure and hypoxia on ECG patterns in two Neotropical freshwater fish species: Matrinxã, Brycon amazonicus and traíra, Hoplias malabaricus. 61
32166694 2020
29
Impact of the repositionable Evolut R CoreValve system on the need for a permanent pacemaker after transcatheter aortic valve implantation in patients with severe aortic stenosis. 61
31062927 2020
30
Risk Prediction Model for Cardiac Implantable Electronic Device Implantation After Transcatheter Aortic Valve Replacement. 61
32192680 2020
31
Prognostic Implication of First-Degree Atrioventricular Block in Patients With Hypertrophic Cardiomyopathy. 61
32146896 2020
32
First-Degree Atrioventricular Block and Hypertrophic Cardiomyopathy: "I Have a Bad Feeling About This". 61
32146897 2020
33
Cardioembolic acute cerebral micro-infarcts in the context of atrial fibrillation after low-dose intravenous infusion of lacosamide. 61
32043469 2020
34
Hydroxychloroquine and Azithromycin as a Treatment of COVID-19: Electrocardiogram Variability. 61
33299775 2020
35
Electrocardiography Interpretation Competency of Medical Interns: Experience from Two Ethiopian Medical Schools. 61
32455024 2020
36
Long-Term Electrocardiographic Changes and Clinical Outcomes of Transcatheter Aortic Valve Implantation Recipients Without New Postprocedural Conduction Disturbances. 61
31732136 2020
37
First-Degree Atrioventricular Block with Tachycardia from Paliperidone and Mirtazapine Overdose. 61
33312997 2020
38
Analysis of cardiac monitoring and safety data in patients initiating fingolimod treatment in the home or in clinic. 61
31729968 2019
39
Pharmacokinetics and Safety of Posaconazole Administered by Intravenous Solution and Oral Tablet in Healthy Chinese Subjects and Effect of Food on Tablet Bioavailability. 61
31432392 2019
40
Prevalence of first-degree atrioventricular block and the associated risk factors: a cross-sectional study in rural Northeast China. 61
31590630 2019
41
One-Year Follow-Up of Conduction Abnormalities After Transcatheter Aortic Valve Implantation With the SAPIEN 3 Valve. 61
31439281 2019
42
Pacemaker implantation in familial amyloid polyneuropathy: when and for whom? 61
30852744 2019
43
Association between PR Interval, First-degree atrioventricular block and major arrhythmic events in patients with Brugada syndrome - Systematic review and meta-analysis. 61
31410227 2019
44
Arrhythmias and Adaptations of the Cardiac Conduction System in Former National Football League Players. 61
31337251 2019
45
Transient left anterior and septal fascicular blocks after self-expandable percutaneous transcatheter aortic valve implantation. 61
29675905 2019
46
Familial Clustering of Cardiac Conduction Defects and Pacemaker Insertion. 61
31216886 2019
47
HYPERTENSIVE HEART DISEASE AND ENCEPHALOPATHY IN A CENTRAL BEARDED DRAGON (POGONA VITTICEPS) WITH SEVERE ATHEROSCLEROSIS AND FIRST-DEGREE ATRIOVENTRICULAR BLOCK. 61
31260220 2019
48
Cardiac disease in mucopolysaccharidosis type III. 61
30671988 2019
49
Occurrence of significant long PR intervals in patients implanted for sinus node dysfunction and monitored with SafeRâ„¢: The PRECISE study. 61
30594571 2019
50
First-degree atrioventricular block on basal electrocardiogram predicts future arrhythmic events in patients with Brugada syndrome: a long-term follow-up study from the Veneto region of Northeastern Italy. 61
29986018 2019
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Variations for First-Degree Atrioventricular Block

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ClinVar genetic disease variations for First-Degree Atrioventricular Block:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 MYH7 , MHRT NM_000257.4(MYH7):c.4717G>A (p.Glu1573Lys) SNV Uncertain significance 222729 rs750987717 GRCh37: 14:23885449-23885449
GRCh38: 14:23416240-23416240
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Expression for First-Degree Atrioventricular Block

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Search GEO for disease gene expression data for First-Degree Atrioventricular Block.
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Pathways for First-Degree Atrioventricular Block

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Pathways related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Dilated cardiomyopathy 36
Show member pathways
 11.53 MYH7 LMNA EMD ACE
2
Antiarrhythmic Pathway, Pharmacodynamics 60
10.67 SCN5A LMNA KCNJ2 KCNH2
3
Cardiomyocyte Differentiation through BMP Receptors 63
10.5 NPPB MYH7
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GO Terms for First-Degree Atrioventricular Block

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Biological processes related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 regulation of ion transmembrane transport GO:0034765 9.73 SCN5A KCNJ2 KCNH2
2 regulation of blood vessel diameter GO:0097746 9.57 NPPB ACE
3 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.55 SCN5A KCNH2
4 nuclear envelope organization GO:0006998 9.54 LMNA DMPK
5 ventricular cardiac muscle cell action potential GO:0086005 9.52 SCN5A KCNH2
6 membrane depolarization during action potential GO:0086010 9.51 SCN5A KCNH2
7 cardiac muscle cell action potential involved in contraction GO:0086002 9.49 SCN5A KCNJ2
8 positive regulation of potassium ion transmembrane transport GO:1901381 9.48 KCNJ2 KCNH2
9 regulation of cardiac muscle cell contraction GO:0086004 9.46 SCN5A KCNJ2
10 membrane depolarization during cardiac muscle cell action potential GO:0086012 9.43 SCN5A KCNJ2
11 regulation of membrane repolarization GO:0060306 9.4 KCNJ2 KCNH2
12 membrane repolarization during cardiac muscle cell action potential GO:0086013 9.37 KCNJ2 KCNH2
13 cardiac conduction GO:0061337 9.33 SCN5A KCNJ2 KCNH2
14 mitotic nuclear envelope reassembly GO:0007084 9.32 LMNA EMD
15 membrane repolarization during action potential GO:0086011 9.26 KCNJ2 KCNH2
16 cardiac muscle contraction GO:0060048 9.13 SCN5A MYH7 KCNH2
17 regulation of heart rate by cardiac conduction GO:0086091 8.8 SCN5A KCNJ2 KCNH2

Molecular functions related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 voltage-gated ion channel activity GO:0005244 9.33 SCN5A KCNJ2 KCNH2
2 inward rectifier potassium channel activity GO:0005242 8.96 KCNJ2 KCNH2
3 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization GO:0086008 8.62 KCNJ2 KCNH2
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Sources for First-Degree Atrioventricular Block

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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