MCID: FRS012
MIFTS: 36

First-Degree Atrioventricular Block

Categories: Cardiovascular diseases

Aliases & Classifications for First-Degree Atrioventricular Block

MalaCards integrated aliases for First-Degree Atrioventricular Block:

Name: First-Degree Atrioventricular Block 12 15
First Degree Atrioventricular Block 6 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050821
ICD10 33 I44.0
UMLS 73 C0085614

Summaries for First-Degree Atrioventricular Block

MalaCards based summary : First-Degree Atrioventricular Block, also known as first degree atrioventricular block, is related to progressive familial heart block, type ia and atrial standstill 1. An important gene associated with First-Degree Atrioventricular Block is MYH7 (Myosin Heavy Chain 7), and among its related pathways/superpathways are Gap junction trafficking and Antiarrhythmic Pathway, Pharmacodynamics. The drugs Fingolimod Hydrochloride and Immunosuppressive Agents have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 76 First-degree atrioventricular block (AV block), or PR prolongation, is a disease of the electrical... more...

Related Diseases for First-Degree Atrioventricular Block

Diseases related to First-Degree Atrioventricular Block via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 32)
# Related Disease Score Top Affiliating Genes
1 progressive familial heart block, type ia 30.1 GJA5 SCN5A
2 atrial standstill 1 29.4 GJA5 MYH7 SCN5A
3 atrioventricular block 10.7
4 cardiac conduction defect 10.3 MYH7 SCN5A
5 peripartum cardiomyopathy 10.2 MYH7 SCN5A
6 cardiomyopathy, dilated, 1e 10.2 MYH7 SCN5A
7 familial isolated dilated cardiomyopathy 10.2 MYH7 SCN5A
8 atrial standstill 10.1 GJA5 SCN5A
9 progressive familial heart block 10.1 GJA5 SCN5A
10 intrinsic cardiomyopathy 10.1 MYH7 SCN5A
11 atrial fibrillation 10.1
12 heart conduction disease 10.0 GJA5 SCN5A
13 hypotrichosis 6 9.9 DSG4 KRT74
14 hypotrichosis 7 9.9 DSG4 KRT74
15 arteries, anomalies of 9.9
16 supravalvular aortic stenosis 9.9
17 atrioventricular dissociation 9.9
18 fabry disease 9.9
19 coronary artery anomaly 9.9
20 extrapulmonary tuberculosis 9.9
21 left bundle branch hemiblock 9.9
22 endocarditis 9.9
23 cholestasis 9.9
24 intrahepatic cholestasis 9.9
25 syncope 9.9
26 hypotrichosis 8 9.9 DSG4 KRT74
27 oculodentodigital dysplasia 9.7 GJA5 GJC1
28 hair disease 9.7 DSG4 KRT74
29 monilethrix 9.6 DSG4 KRT74
30 familial atrial fibrillation 9.4 GJA5 SCN5A
31 heart disease 9.2 GJA5 MYH7 SCN5A
32 sinoatrial node disease 9.2 GJA5 GJC1 SCN5A

Comorbidity relations with First-Degree Atrioventricular Block via Phenotypic Disease Network (PDN): (show all 44)


Acute Cystitis Acute Kidney Failure
Anxiety Aortic Atherosclerosis
Aortic Valve Disease 1 Atrioventricular Block
Benign Essential Hypertension Bronchitis
Cardiac Arrest Cardiac Arrhythmia
Chronic Kidney Failure Chronic Myocardial Ischemia
Deficiency Anemia Dressler's Syndrome
Esophagitis Familial Atrial Fibrillation
Generalized Atherosclerosis Gout
Heart Disease Hyperlipoproteinemia, Type Iv
Hypertension, Essential Hypertrophic Cardiomyopathy
Hypoglycemia Hypothyroidism
Intermediate Coronary Syndrome Iron Deficiency Anemia
Ischemic Heart Disease Kidney Disease
Left Bundle Branch Hemiblock Malignant Essential Hypertension
Mitral Valve Disease Mobitz Type Ii Atrioventricular Block
Osteoarthritis Peripheral Vascular Disease
Postinflammatory Pulmonary Fibrosis Progressive Familial Heart Block, Type Ia
Prostatic Hypertrophy Pulmonary Hypertension, Primary, 1
Right Bundle Branch Block Sinoatrial Node Disease
Third-Degree Atrioventricular Block Transient Cerebral Ischemia
Tricuspid Valve Disease Ventricular Fibrillation, Paroxysmal Familial, 1

Graphical network of the top 20 diseases related to First-Degree Atrioventricular Block:



Diseases related to First-Degree Atrioventricular Block

Symptoms & Phenotypes for First-Degree Atrioventricular Block

GenomeRNAi Phenotypes related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-134 9.5 MYH7
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.5 DSG4 GJA5 MYH7 SCN5A
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.5 MYH7
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-184 9.5 MYH7
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.5 GJA5
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-204 9.5 DSG4
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-209 9.5 DSG4
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-211 9.5 GJA5
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.5 DSG4
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-58 9.5 SCN5A
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-61 9.5 GJA5
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-62 9.5 GJA5

MGI Mouse Phenotypes related to First-Degree Atrioventricular Block:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.35 GJA5 GJC1 MYH7 SCN5A TSPO
2 muscle MP:0005369 8.92 GJA5 GJC1 MYH7 SCN5A

Drugs & Therapeutics for First-Degree Atrioventricular Block

Drugs for First-Degree Atrioventricular Block (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 35)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fingolimod Hydrochloride Phase 4
2 Immunosuppressive Agents Phase 4
3 Antibodies Phase 2, Phase 3
4 Autoantibodies Phase 2, Phase 3
5 gamma-Globulins Phase 2, Phase 3
6 Immunoglobulins Phase 2, Phase 3
7 Immunoglobulins, Intravenous Phase 2, Phase 3
8 Rho(D) Immune Globulin Phase 2, Phase 3
9
Hydroxychloroquine Approved Phase 2 118-42-3 3652
10
Emtricitabine Approved, Investigational Phase 2 143491-57-0 60877
11
Ritonavir Approved, Investigational Phase 2 155213-67-5 392622
12 Epoetin alfa Phase 2 113427-24-0
13 Hematinics Phase 2
14 Prolyl-Hydroxylase Inhibitors Phase 2
15 Anti-Infective Agents Phase 2
16 Antimalarials Phase 2
17 Antiparasitic Agents Phase 2
18 Antiprotozoal Agents Phase 2
19 Antirheumatic Agents Phase 2
20 Anti-HIV Agents Phase 2
21 Anti-Retroviral Agents Phase 2
22 Antiviral Agents Phase 2
23 Atazanavir Sulfate Phase 2
24 Cytochrome P-450 CYP3A Inhibitors Phase 2
25 Cytochrome P-450 Enzyme Inhibitors Phase 2
26 HIV Integrase Inhibitors Phase 2
27 HIV Protease Inhibitors Phase 2
28 Integrase Inhibitors Phase 2
29 Nucleic Acid Synthesis Inhibitors Phase 2
30
protease inhibitors Phase 2
31 Raltegravir Potassium Phase 2
32 Reverse Transcriptase Inhibitors Phase 2
33
Tenofovir Phase 2 147127-20-6 464205
34
Lacosamide Approved 860352-01-8, 175481-36-4 219078
35 Anticonvulsants

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 STudy to vAlidate telemetRic ECG Systems for firsT Dose Administration of Fingolimod (START) Completed NCT01585298 Phase 4 FTY720
2 Preventive IVIG Therapy for Congenital Heart Block Completed NCT00460928 Phase 2, Phase 3 intravenous immune globulin (IVIG)
3 4 Week Switch Study in Hemodialysis-dependent Subjects With Anemia Associated With Chronic Kidney Disease Completed NCT01587924 Phase 2 GSK1278863;rhEPO
4 Preventive Approach to Congenital Heart Block With Hydroxychloroquine Recruiting NCT01379573 Phase 2 Hydroxychloroquine
5 Phase IIB Pilot of Atazanavir + Raltegravir Terminated NCT00768989 Phase 2 Atazanavir;Raltegravir;Atazanavir;Ritonavir;Tenofovir/Emtricitabine
6 Minimizing Ventricular Pacing Unknown status NCT01611389 Not Applicable
7 BiventRicular Pacing in prolongEd Atrio-Ventricular intervaL: the REAL-CRT Study Unknown status NCT02150538 Not Applicable
8 Pacing in First-degree AV-block Completed NCT01985802 Not Applicable
9 Evolution of the PR Interval in Patients Implanted With a Pacemaker Using the SafeR Mode Completed NCT02586480
10 Post-Authorization Safety Study to Assess the Safety of Vimpat as add-on Therapy in Patients With Partial-onset Seizures Completed NCT00771927 Lacosamide
11 Cardiac Dysfunction in Traumatic Brain Injury Completed NCT03566368
12 Comparison Between Standard and Ultrasound Integrated Approach for Risk Stratification of Syncope in the Emergency Department Recruiting NCT02781207
13 STIMTAVI : Evolution of Atrioventricular Conduction Disorders After TAVI Active, not recruiting NCT03338582
14 Magnesium Effect on Embryonal PR Interval Not yet recruiting NCT03047304 Not Applicable
15 Restoration of Atrioventricular Synchrony Trial Terminated NCT01275833 Not Applicable

Search NIH Clinical Center for First-Degree Atrioventricular Block

Genetic Tests for First-Degree Atrioventricular Block

Anatomical Context for First-Degree Atrioventricular Block

MalaCards organs/tissues related to First-Degree Atrioventricular Block:

41
Heart, Kidney, Brain

Publications for First-Degree Atrioventricular Block

Articles related to First-Degree Atrioventricular Block:

(show all 31)
# Title Authors Year
1
Treatment of intrahepatic cholestasis of pregnancy with ursodeoxycholic acid associated with improvement of fetal first-degree atrioventricular block. ( 29484735 )
2018
2
Marked First-Degree Atrioventricular Block and Pseudo-Pacemaker Syndrome in a Pediatric Patient. ( 29435607 )
2018
3
Slow pathway modification for treatment of pseudo-pacemaker syndrome due to first-degree atrioventricular block with dual atrioventricular nodal physiology. ( 29707483 )
2018
4
Symptomatic first-degree atrioventricular block in a young woman after taking a fat burner supplement. ( 29162998 )
2017
5
Marked Symptomatic Sinus Bradycardia With New Onset First-Degree Atrioventricular Block After Concomitant Methadone and Trazodone Use. ( 28953513 )
2017
6
Pregabalin-induced first degree atrioventricular block in a young patient treated for pain from extrapulmonary tuberculosis. ( 29424197 )
2017
7
First-degree atrioventricular block: risk marker or innocent finding? ( 26936340 )
2016
8
Outcomes Related to First-Degree Atrioventricular Block and Therapeutic Implications in Patients With Heart Failure. ( 29766868 )
2016
9
First-degree atrioventricular block is associated with advanced atrioventricular block, atrial fibrillation and left ventricular dysfunction in patients with hypertension. ( 24695396 )
2014
10
First-degree atrioventricular block may not be that benign after all. ( 24695392 )
2014
11
First-degree atrioventricular block is associated with advanced atrioventricular block, atrial fibrillation and left ventricular dysfunction in patients with hypertension. ( 24509124 )
2014
12
Association of WPW syndrome and first-degree atrioventricular block : Electrocardiographic diagnosis. ( 23873008 )
2014
13
Marked First Degree Atrioventricular Block: an extremely prolonged PR interval associated with Atrioventricular Dissociation in a young Nigerian man with Pseudo-Pacemaker Syndrome: a case report. ( 25371009 )
2014
14
First-degree atrioventricular block and pseudopacemaker syndrome. ( 23791585 )
2013
15
Short- and long-term outcomes depending on electrical dyssynchrony markers in patients presenting with acute heart failure: clinical implication of the first-degree atrioventricular block and QRS prolongation from the Korean Heart Failure registry. ( 23237134 )
2013
16
Coronary Artery to Right Atrium Fistula Associated With First Degree Atrioventricular Block: A Rare Association. ( 26316663 )
2013
17
Profound first-degree atrioventricular block. ( 24057329 )
2013
18
Atazanavir induced first degree atrioventricular block and ventricular tachycardia: a case report. ( 23691707 )
2013
19
Significance of first-degree atrioventricular block in acute endocarditis. ( 23440164 )
2013
20
Conventional and biventricular pacing in patients with first-degree atrioventricular block. ( 22516061 )
2012
21
First-degree atrioventricular block is associated with heart failure and death in persons with stable coronary artery disease: data from the Heart and Soul Study. ( 21606074 )
2011
22
Second diastolic pulmonary venous flow and isolated late diastolic mitral valve regurgitation in first-degree atrioventricular block. ( 19933289 )
2010
23
Long-term outcomes in individuals with prolonged PR interval or first-degree atrioventricular block. ( 19549974 )
2009
24
Reversal of first-degree atrioventricular block in Fabry disease. ( 19901148 )
2009
25
Outcomes in patients with prolonged PR interval or first-degree atrioventricular block. ( 19903913 )
2009
26
Outcomes in patients with prolonged PR interval or first-degree atrioventricular block. ( 19903912 )
2009
27
Prevention of complete heart block in children of mothers with anti-SSA/Ro and anti-SSB/La autoantibodies: detection and treatment of first-degree atrioventricular block. ( 19584727 )
2009
28
Ecg of the month. Unusual electrocardiogram 42 years after operation for supravalvular aortic stenosis and 6 years after aortic valve replacement. Sinus rhythm with first degree atrioventricular block. ( 18681350 )
2008
29
Transient syncope, left bundle branch block and first degree atrioventricular block after &amp;quot;pill-in-the-pocket&amp;quot; administration. ( 17408787 )
2008
30
First-degree atrioventricular block. Clinical manifestations, indications for pacing, pacemaker management &amp;amp; consequences during cardiac resynchronization. ( 17334913 )
2006
31
First-degree atrioventricular block in alprazolam overdose reversed by flumazenil. ( 10344640 )
1999

Variations for First-Degree Atrioventricular Block

ClinVar genetic disease variations for First-Degree Atrioventricular Block:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 MYH7 NM_000257.3(MYH7): c.4717G> A (p.Glu1573Lys) single nucleotide variant Uncertain significance rs750987717 GRCh37 Chromosome 14, 23885449: 23885449
2 MYH7 NM_000257.3(MYH7): c.4717G> A (p.Glu1573Lys) single nucleotide variant Uncertain significance rs750987717 GRCh38 Chromosome 14, 23416240: 23416240

Expression for First-Degree Atrioventricular Block

Search GEO for disease gene expression data for First-Degree Atrioventricular Block.

Pathways for First-Degree Atrioventricular Block

Pathways related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.95 GJA5 GJC1
2 10.37 GJA5 SCN5A

GO Terms for First-Degree Atrioventricular Block

Cellular components related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gap junction GO:0005921 9.16 GJA5 GJC1
2 connexin complex GO:0005922 8.96 GJA5 GJC1
3 intercalated disc GO:0014704 8.8 GJA5 GJC1 SCN5A

Biological processes related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cornification GO:0070268 9.57 DSG4 KRT74
2 muscle contraction GO:0006936 9.56 GJC1 MYH7
3 cell communication GO:0007154 9.55 GJA5 GJC1
4 cardiac conduction GO:0061337 9.54 GJA5 SCN5A
5 cardiac muscle contraction GO:0060048 9.52 MYH7 SCN5A
6 regulation of heart rate by cardiac conduction GO:0086091 9.51 GJA5 SCN5A
7 regulation of heart rate GO:0002027 9.49 MYH7 SCN5A
8 regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 9.48 GJA5 SCN5A
9 ventricular cardiac muscle cell action potential GO:0086005 9.46 GJA5 SCN5A
10 regulation of atrial cardiac muscle cell membrane depolarization GO:0060371 9.43 GJA5 SCN5A
11 atrial cardiac muscle cell action potential GO:0086014 9.4 GJC1 SCN5A
12 regulation of ventricular cardiac muscle cell membrane depolarization GO:0060373 9.37 GJA5 SCN5A
13 gap junction assembly GO:0016264 9.32 GJA5 GJC1
14 SA node cell action potential GO:0086015 9.26 GJA5 SCN5A
15 AV node cell to bundle of His cell communication GO:0086067 9.16 GJA5 SCN5A
16 AV node cell to bundle of His cell communication by electrical coupling GO:0086053 8.96 GJA5 GJC1
17 SA node cell to atrial cardiac muscle cell communication by electrical coupling GO:0086021 8.62 GJA5 GJC1

Molecular functions related to First-Degree Atrioventricular Block according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel binding GO:0044325 9.26 SCN5A TSPO
2 gap junction channel activity GO:0005243 9.16 GJA5 GJC1
3 gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling GO:0086077 8.96 GJA5 GJC1
4 gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling GO:0086020 8.62 GJA5 GJC1

Sources for First-Degree Atrioventricular Block

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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