MCID: FSS001
MIFTS: 32

Fissured Tongue

Categories: Gastrointestinal diseases, Oral diseases

Aliases & Classifications for Fissured Tongue

MalaCards integrated aliases for Fissured Tongue:

Name: Fissured Tongue 12 76 15 73
Tongue, Fissured 12 44
Furrowed Tongue 12 29
Geographic Tongue and Fissured Tongue 12
Fissure of Tongue, Congenital 12
Congenital Fissure of Tongue 12
Congenital Plicated Tongue 12
Fissure of Tongue 12
Plicated Tongue 12
Lingua Plicata 12
Scrotal Tongue 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11514
ICD10 33 K14.5
ICD9CM 35 529.5
MeSH 44 D014063
SNOMED-CT 68 204627005 52368004
UMLS 73 C0040412

Summaries for Fissured Tongue

MalaCards based summary : Fissured Tongue, also known as tongue, fissured, is related to glossitis and median rhomboid glossitis, and has symptoms including glossalgia An important gene associated with Fissured Tongue is KRT6A (Keratin 6A), and among its related pathways/superpathways are Cytoskeleton remodeling Neurofilaments and Striated Muscle Contraction. Affiliated tissues include tongue.

Wikipedia : 76 Fissured tongue (also known as \"scrotal tongue,\" \"lingua plicata,\" \"Plicated tongue,\" and... more...

Related Diseases for Fissured Tongue

Graphical network of the top 20 diseases related to Fissured Tongue:



Diseases related to Fissured Tongue

Symptoms & Phenotypes for Fissured Tongue

UMLS symptoms related to Fissured Tongue:


glossalgia

Drugs & Therapeutics for Fissured Tongue

Search Clinical Trials , NIH Clinical Center for Fissured Tongue

Cochrane evidence based reviews: tongue, fissured

Genetic Tests for Fissured Tongue

Genetic tests related to Fissured Tongue:

# Genetic test Affiliating Genes
1 Furrowed Tongue 29

Anatomical Context for Fissured Tongue

MalaCards organs/tissues related to Fissured Tongue:

41
Tongue

Publications for Fissured Tongue

Articles related to Fissured Tongue:

(show all 32)
# Title Authors Year
1
Fissured tongue in patients with psoriasis. ( 29332713 )
2018
2
Recurrent episodes of peripheral facial nerve palsy and fissured tongue. ( 28573802 )
2017
3
Recurrent episodes of peripheral facial nerve palsy and fissured tongue. ( 28573805 )
2017
4
Oral medicine: Factors associated with geographic tongue and fissured tongue. ( 27388082 )
2016
5
Frequency of fissured tongue (lingua plicata) as a function of age. ( 27808348 )
2016
6
Factors associated with geographic tongue and fissured tongue. ( 26381370 )
2015
7
Geographic tongue and fissured tongue in 348 patients with psoriasis: correlation with disease severity. ( 25685842 )
2015
8
Newer Classification System for Fissured Tongue: An Epidemiological Approach. ( 26457087 )
2015
9
Fissured tongue: a sign of tongue edema? ( 24698850 )
2014
10
Prevalence of fungi in cases of geographical and fissured tongue. ( 24881280 )
2013
11
HLA alleles in Brazilian patients with fissured tongue. ( 22458812 )
2013
12
Fissured tongue responding to biologics during the treatment of psoriasis: the importance of detecting oral involvement of psoriasis. ( 23914894 )
2013
13
Two novel de novo mutations of KRT6A and KRT16 genes in two Chinese pachyonychia congenita pedigrees with fissured tongue or diffuse plantar keratoderma. ( 22668561 )
2012
14
Benign migratory glossitis with fissured tongue. ( 22918106 )
2012
15
Gingival fibromatosis with hemi-osseous hyperplasia of jaws, focal maxillary viral papillomatosis of gingiva, fissured tongue and congenitally missing anterior teeth: a case report and surgical management of a new syndrome. ( 22048596 )
2011
16
HLA alleles and fissured tongue. ( 20572893 )
2010
17
A case of a deeply fissured tongue. ( 20416535 )
2010
18
Recurrent geographical tongue and fissured tongue in association with pregnancy. ( 17243991 )
2007
19
The prevalence and significance of fissured tongue and geographical tongue in psoriatic patients. ( 16487088 )
2006
20
Prevalence of fissured tongue, geographic tongue and median rhomboid glossitis among Israeli adults of different ethnic origins. ( 15316160 )
2004
21
Fissured tongue in generalized pustular psoriasis. ( 8215509 )
1993
22
The possible significance of fissured tongue in tuberculosis patients. ( 1862434 )
1991
23
Familial study of fissured tongue. ( 3166201 )
1988
24
Haematological and immunological features of patients with fissured tongue syndrome. ( 3480001 )
1987
25
A scanning electron microscopic study of fissured tongue. ( 3083069 )
1986
26
Changes in composition of whole saliva in patients with fissured tongue. ( 3868014 )
1985
27
Occurrence of fissured tongue, geographic tongue and filiform atrophy among dental patients in Saudi Arabia. ( 3867320 )
1985
28
Nonpainful, erythematous, circinate lesions of a protean nature on a fissured tongue. ( 6589298 )
1984
29
The incidence of fissured tongue among 4,009 Iranian dental outpatients. ( 4514524 )
1973
30
Prevalence of geographic tongue, fissured tongue, median rhomboid glossitis, and hairy tongue among 3,611 Minnesota schoolchildren. ( 5270895 )
1970
31
Some observations on 1246 cases of geographic tongue: the association between geographic tongue, seborrheic dermatitis, and spasmodic bronchitis; transition of geographic tongue to fissured tongue. ( 13410386 )
1957
32
The occurrence of Fordyce spots, benign migratory glossitis, median rhomboid glossitis, and fissured tongue in 2,478 dental patients. ( 13088005 )
1953

Variations for Fissured Tongue

Expression for Fissured Tongue

Search GEO for disease gene expression data for Fissured Tongue.

Pathways for Fissured Tongue

Pathways related to Fissured Tongue according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.99 KRT16 KRT6A
2 10.48 TNNI2 TNNT3

GO Terms for Fissured Tongue

Cellular components related to Fissured Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.96 KRT16 KRT6A
2 troponin complex GO:0005861 8.62 TNNI2 TNNT3

Biological processes related to Fissured Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoskeleton organization GO:0007010 9.46 KRT16 KRT6A
2 cornification GO:0070268 9.43 KRT16 KRT6A
3 muscle contraction GO:0006936 9.4 TNNI2 TNNT3
4 cardiac muscle contraction GO:0060048 9.37 TNNI2 TNNT3
5 muscle filament sliding GO:0030049 9.32 TNNI2 TNNT3
6 skeletal muscle contraction GO:0003009 9.26 TNNI2 TNNT3
7 morphogenesis of an epithelium GO:0002009 9.16 KRT16 KRT6A
8 intermediate filament cytoskeleton organization GO:0045104 8.96 KRT16 KRT6A
9 regulation of muscle contraction GO:0006937 8.62 TNNI2 TNNT3

Molecular functions related to Fissured Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of cytoskeleton GO:0005200 8.62 KRT16 KRT6A

Sources for Fissured Tongue

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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