MCID: FSS001
MIFTS: 30

Fissured Tongue

Categories: Gastrointestinal diseases, Oral diseases, Smell/Taste diseases

Aliases & Classifications for Fissured Tongue

MalaCards integrated aliases for Fissured Tongue:

Name: Fissured Tongue 12 73 15 70
Tongue, Fissured 12 44
Furrowed Tongue 12 29
Plicated Tongue 12 32
Geographic Tongue and Fissured Tongue 12
Fissure of Tongue, Congenital 12
Congenital Fissure of Tongue 12
Congenital Plicated Tongue 12
Fissure of Tongue 12
Lingua Plicata 12
Scrotal Tongue 12

Classifications:



External Ids:

Disease Ontology 12 DOID:11514
ICD9CM 34 529.5
MeSH 44 D014063
SNOMED-CT 67 52368004
ICD10 32 K14.5
UMLS 70 C0040412

Summaries for Fissured Tongue

MalaCards based summary : Fissured Tongue, also known as tongue, fissured, is related to glossitis and median rhomboid glossitis, and has symptoms including glossalgia An important gene associated with Fissured Tongue is KRT6A (Keratin 6A). Affiliated tissues include tongue, eye and kidney.

Wikipedia : 73 Fissured tongue is a benign condition characterized by deep grooves (fissures) in the dorsum of the... more...

Related Diseases for Fissured Tongue

Diseases related to Fissured Tongue via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Related Disease Score Top Affiliating Genes
1 glossitis 31.1 KRT6A KRT16
2 median rhomboid glossitis 31.0 KRT6A KRT16
3 focal palmoplantar keratoderma 30.4 KRT6A KRT16
4 pachyonychia congenita 1 30.1 KRT6A KRT16
5 palmoplantar keratosis 30.0 KRT6A KRT16
6 ophthalmoplegia, progressive, with scrotal tongue and mental deficiency 11.3
7 geographic and fissured tongue 11.2
8 melkersson-rosenthal syndrome 11.1
9 orofacial granulomatosis 11.1
10 geographic tongue 10.6
11 pustulosis of palm and sole 10.4
12 psoriasis 10.4
13 hairy tongue 10.2
14 palmoplantar keratoderma, nonepidermolytic 10.2 KRT6A KRT16
15 palmoplantar keratoderma, nonepidermolytic, focal or diffuse 10.2 KRT6A KRT16
16 palmoplantar keratoderma, nonepidermolytic, focal 1 10.2 KRT6A KRT16
17 steatocystoma multiplex 10.2 KRT6A KRT16
18 palmoplantar keratoderma, epidermolytic 10.2 KRT6A KRT16
19 facial paralysis 10.2
20 down syndrome 10.1
21 bell's palsy 10.1
22 oral candidiasis 10.1
23 candidiasis 10.1
24 waardenburg's syndrome 10.1
25 chromosomal triplication 10.1
26 fazio-londe disease 10.1
27 achalasia-addisonianism-alacrima syndrome 10.1
28 arthrogryposis, distal, type 2b1 10.1 TNNT3 TNNI2
29 arthrogryposis, distal, type 1b 10.0 TNNT3 TNNI2
30 lethal congenital contracture syndrome 4 10.0 TNNT3 TNNI2
31 arthrogryposis, distal, type 7 10.0 TNNT3 TNNI2
32 psoriasis 14, pustular 10.0
33 pachyonychia congenita 3 10.0
34 gingival fibromatosis 10.0
35 papilloma 10.0
36 dermatitis 10.0
37 bronchitis 10.0
38 seborrheic dermatitis 10.0
39 fibromatosis 10.0
40 pustular psoriasis 10.0
41 camptodactyly-arthropathy-coxa vara-pericarditis syndrome 10.0 TNNT3 TNNI2
42 spondylocarpotarsal synostosis syndrome 9.9 TNNT3 TNNI2
43 angular cheilitis 9.9 STATH KRT6A AAAS
44 arthrogryposis, distal, type 5 9.9 TNNT3 TNNI2 ECEL1
45 arthrogryposis, distal, type 5d 9.9 TNNT3 TNNI2 ECEL1
46 monilethrix 9.9 KRT6A KRT16
47 arthrogryposis, distal, type 10 9.9 TNNT3 TNNI2 ECEL1
48 arthrogryposis, distal, type 2a 9.9 TNNT3 TNNI2 ECEL1
49 multiple pterygium syndrome, escobar variant 9.9 TNNT3 TNNI2 ECEL1
50 ankyloglossia with or without tooth anomalies 9.9

Graphical network of the top 20 diseases related to Fissured Tongue:



Diseases related to Fissured Tongue

Symptoms & Phenotypes for Fissured Tongue

UMLS symptoms related to Fissured Tongue:


glossalgia

Drugs & Therapeutics for Fissured Tongue

Search Clinical Trials , NIH Clinical Center for Fissured Tongue

Cochrane evidence based reviews: tongue, fissured

Genetic Tests for Fissured Tongue

Genetic tests related to Fissured Tongue:

# Genetic test Affiliating Genes
1 Furrowed Tongue 29

Anatomical Context for Fissured Tongue

MalaCards organs/tissues related to Fissured Tongue:

40
Tongue, Eye, Kidney

Publications for Fissured Tongue

Articles related to Fissured Tongue:

(show top 50) (show all 271)
# Title Authors PMID Year
1
A case of Melkersson-Rosenthal syndrome with endocrine disorders: Extraordinary efficiency of hydroxychloroquine and mechanism hypothesis. 61
33270950 2021
2
Melkersson-Rosenthal Syndrome Induced by COVID-19. 61
32829989 2021
3
Salivary pH and oral health of Brazilian para-athletes: Saliva and oral health of para-athletes. 61
33749857 2021
4
Clinical Profile of Melkersson-Rosenthal Syndrome/Orofacial Granulomatosis: A Review of 51 Patients. 61
33573395 2021
5
Presentation of Bilateral Facial Paralysis in Melkersson-Rosenthal Syndrome. 61
33505744 2021
6
Melkersson-Rosenthal syndrome misdiagnosed as recurrent Bell's palsy: a case report and review of literature. 61
33422123 2021
7
PPP1R21-related syndromic intellectual disability: Report of an adult patient and review. 61
32985083 2020
8
Melkersson-Rosenthal Syndrome: a Case Report of the Classic Triad. 61
33344685 2020
9
Uncommon Coronary Abnormalities in a Patient with Discoid Lupus Erythematosus. 61
33268978 2020
10
Prevalence of oral mucosal normal variations and lesions in a middle-aged population: a Northern Finland Birth Cohort 1966 study. 61
33298037 2020
11
[Recurrent peripheral facial nerve palsy]. 61
33631910 2020
12
An Intriguing Case of Ectopic Benign Migratory Glossitis Resembling Secondary Syphilis: A Case Report. 61
33442352 2020
13
Think Melkersson-Rosenthal Syndrome: A Fissured Tongue With Facial Paralysis. 61
32874808 2020
14
Oral health status of patients with multiple myeloma. 61
31582338 2020
15
A Rare Case of Extensive Pemphigus Vegetans. 61
32055517 2020
16
Panuveitis revealing Melkersson Rosenthal syndrome: a case report. 61
32395783 2020
17
Temporomandibular Disorders and Oral Features in Systemic Lupus Erythematosus Patients: An Observational Study of Symptoms and Signs. 61
32038098 2020
18
Goldenhar Syndrome in a Young Girl. 61
31659973 2019
19
Oral manifestation in leprosy: A cross-sectional study of 100 cases with literature review. 61
31803674 2019
20
Fissured tongue. 61
31710590 2019
21
Melkersson-Rosenthal syndrome: About a Tunisian family and review of the literature. 61
31445326 2019
22
Geographic stomatitis: An enigmatic condition with multiple clinical presentations. 61
31636878 2019
23
Melkersson-Rosenthal syndrome with coeliac and allergic diseases. 61
31466978 2019
24
[Study on the oral mucosal diseases in patients with cerebrovascular diseases]. 61
31484269 2019
25
World Workshop on Oral Medicine VII: Relative frequency of oral mucosal lesions in children, a scoping review. 61
31034120 2019
26
Association of geographic tongue and fissured tongue with ABO blood group among adult psoriasis patients: a novel study from a tertiary care hospital in Saudi Arabia. 61
30902460 2019
27
Genetic and developmental disorders of the oral mucosa: Epidemiology; molecular mechanisms; diagnostic criteria; management. 61
31090139 2019
28
Melkerssonā»Rosenthal Syndrome in Childhood: Report of Three Paediatric Cases and a Review of the Literature. 61
30974872 2019
29
Melkersson-Rosenthal syndrome: a case report of a rare disease with overlapping features. 61
30622569 2019
30
[Recurrent and alternating peripheral facial palsy in a Rehabilitation department]. 61
30929833 2019
31
Predictive Value of Fissured Tongue in Functional Dyspepsia Combined with Depression. 61
31316559 2019
32
Comparing the Frequency of Some Oral Lesions in Prediabetic and Healthy Individuals: Is There Any Difference? 61
32133095 2019
33
Oral mucosal lesions and risk of all-cause and cardiovascular mortality in people treated with long-term haemodialysis: The ORAL-D multinational cohort study. 61
31226151 2019
34
Correlation between halitosis, oral health status and salivary ß-galactosidases and time spent in physical activities in children. 61
30567440 2018
35
Tongue Atrophy in Sjögren Syndrome Patients with Mucosa-associated Lymphoid Tissue Lymphoma: Autoimmune Epithelitis beyond the Epithelial Cells of Salivary Glands? 61
30008454 2018
36
Tongue psoriasis: Clinical aspects and analysis of epidemiological associations in 313 children, with a systematic literature review. 61
29773283 2018
37
Tooth agenesis: A susceptible indicator for colorectal cancer? 61
29893310 2018
38
Oral features in patients with psoriasis: an observational study. 61
29307171 2018
39
Fissured tongue in patients with psoriasis. 61
29332713 2018
40
Prevalence and Distribution of Oral Mucosal Lesions by Sex and Age Categories: A Retrospective Study of Patients Attending Lebanese School of Dentistry. 61
29887889 2018
41
Digestive system in psoriasis: an update. 61
28905102 2017
42
Comparative study: Oral mucosal lesions, signs and symptoms in diabetes mellitus patients with end stage renal disease with analogous findings in diabetes mellitus patients with non-end stage renal disease. 61
28836532 2017
43
Recurrent episodes of peripheral facial nerve palsy and fissured tongue. 61
28573805 2017
44
Recurrent episodes of peripheral facial nerve palsy and fissured tongue. 61
28573802 2017
45
[Melkersson-Rosenthal syndrome in a young man]. 61
28606298 2017
46
Oral diseases: a 14-year experience of a Chilean institution with a systematic review from eight countries. 61
28390130 2017
47
Investigation of the clinical features of geographic tongue: unveiling its relationship with oral psoriasis. 61
28188609 2017
48
Oral mucosal lesions in a Chilean elderly population: A retrospective study with a systematic review from thirteen countries. 61
28210449 2017
49
Dental management and orofacial manifestations of a patient with Robinow Syndrome. 61
28955595 2017
50
Host and clinical aspects in patients with benign migratory glossitis. 61
27810384 2017

Variations for Fissured Tongue

Expression for Fissured Tongue

Search GEO for disease gene expression data for Fissured Tongue.

Pathways for Fissured Tongue

GO Terms for Fissured Tongue

Cellular components related to Fissured Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 troponin complex GO:0005861 8.62 TNNT3 TNNI2

Biological processes related to Fissured Tongue according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 learning GO:0007612 9.32 SYNJ1 AAAS
2 muscle filament sliding GO:0030049 9.26 TNNT3 TNNI2
3 skeletal muscle contraction GO:0003009 9.16 TNNT3 TNNI2
4 morphogenesis of an epithelium GO:0002009 8.96 KRT6A KRT16
5 regulation of muscle contraction GO:0006937 8.62 TNNT3 TNNI2

Sources for Fissured Tongue

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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