MCID: FXD003
MIFTS: 36

Fixed Drug Eruption

Categories: Skin diseases, Rare diseases

Aliases & Classifications for Fixed Drug Eruption

MalaCards integrated aliases for Fixed Drug Eruption:

Name: Fixed Drug Eruption 59 73

Characteristics:

Orphanet epidemiological data:

59
fixed drug eruption
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA293812
UMLS via Orphanet 74 C0877391
UMLS 73 C0221242

Summaries for Fixed Drug Eruption

MalaCards based summary : Fixed Drug Eruption is related to erythema multiforme and lower lip cancer, and has symptoms including integumentary system signs and symptoms An important gene associated with Fixed Drug Eruption is CCR7 (C-C Motif Chemokine Receptor 7), and among its related pathways/superpathways are PEDF Induced Signaling and Akt Signaling. The drug Petrolatum has been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related phenotypes are cellular and hematopoietic system

Related Diseases for Fixed Drug Eruption

Diseases related to Fixed Drug Eruption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 erythema multiforme 29.7 IFNG IL2
2 lower lip cancer 10.5 CASP3 IL2
3 pars planitis 10.4 CCR7 CD27
4 toxicodendron dermatitis 10.2 IL2 SELL
5 boutonneuse fever 10.2 IL2 SELL
6 b-cell expansion with nfkb and t-cell anergy 10.1 IL2 SELL
7 dermatitis 10.1
8 autoimmune progesterone dermatitis 10.1
9 severe cutaneous adverse reaction 10.0
10 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.0
11 variola major 10.0 IFNG IL2
12 autoimmune myocarditis 10.0 IFNG IL2
13 berylliosis 10.0 IFNG IL2
14 atopic keratoconjunctivitis 10.0 IFNG IL2
15 clonorchiasis 9.9 IFNG IL2
16 crohn's colitis 9.9 IFNG IL2
17 microscopic colitis 9.9 IFNG IL2
18 chronic active epstein-barr virus infection 9.9 IFNG IL2
19 posterior uveitis 9.9 IFNG IL2
20 intermediate uveitis 9.9 IFNG IL2
21 vulvovaginal candidiasis 9.9 IFNG IL2
22 coccidiosis 9.9 IFNG IL2
23 hematopoietic stem cell transplantation 9.9 IFNG IL2
24 autoimmune disease of endocrine system 9.9 IFNG IL2
25 lepromatous leprosy 9.9 IFNG IL2
26 epididymitis 9.9
27 exanthem 9.9
28 balanitis 9.9
29 hypersensitivity reaction type iv disease 9.9 IFNG IL2
30 acute graft versus host disease 9.9 IFNG IL2
31 vernal conjunctivitis 9.9 IFNG IL2
32 herpes zoster 9.9 IFNG IL2
33 paracoccidioidomycosis 9.9 IFNG IL2
34 brucellosis 9.9 IFNG IL2
35 mumps 9.9 IFNG IL2
36 tonsillitis 9.9 IFNG IL2
37 human immunodeficiency virus infectious disease 9.8 IFNG IL2
38 leprosy 3 9.8 IFNG IL2
39 tropical spastic paraparesis 9.8 IFNG IL2
40 spondyloarthropathy 9.8 IFNG IL2
41 smallpox 9.8 IFNG IL2
42 conjunctivitis 9.8 IFNG IL2
43 filariasis 9.8 IFNG IL2
44 t-cell leukemia 9.8 CASP3 CCR4 IL2
45 parasitic protozoa infectious disease 9.8 IFNG IL2
46 keratoconjunctivitis 9.8 IFNG IL2
47 cellulitis 9.7
48 folliculitis 9.7
49 dermatitis herpetiformis 9.7
50 dermatitis herpetiformis, familial 9.7

Graphical network of the top 20 diseases related to Fixed Drug Eruption:



Diseases related to Fixed Drug Eruption

Symptoms & Phenotypes for Fixed Drug Eruption

UMLS symptoms related to Fixed Drug Eruption:


integumentary system signs and symptoms

MGI Mouse Phenotypes related to Fixed Drug Eruption:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 IL2 SELL CASP3 CCR7 CD27 IFNG
2 hematopoietic system MP:0005397 9.7 CASP3 CCR4 CCR7 CD27 IFNG IL2
3 endocrine/exocrine gland MP:0005379 9.65 CASP3 CCR7 IFNG IL2 SELL
4 immune system MP:0005387 9.5 CASP3 CCR4 CCR7 CD27 IFNG IL2
5 respiratory system MP:0005388 9.02 CASP3 CCR4 IFNG IL2 SELL

Drugs & Therapeutics for Fixed Drug Eruption

Drugs for Fixed Drug Eruption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Petrolatum Approved, Investigational Not Applicable 8009-03-8

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Severe Cutaneous Adverse Reactions in Thailand Unknown status NCT02574988
2 Drug Patch Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs) Recruiting NCT03176342 Not Applicable

Search NIH Clinical Center for Fixed Drug Eruption

Genetic Tests for Fixed Drug Eruption

Anatomical Context for Fixed Drug Eruption

MalaCards organs/tissues related to Fixed Drug Eruption:

41
Testes, Skin, T Cells, Liver

Publications for Fixed Drug Eruption

Articles related to Fixed Drug Eruption:

(show all 46)
# Title Authors Year
1
Bullous Fixed Drug Eruption Following Ibuprofen Ingestion. ( 29756000 )
2018
2
Ciprofloxacin-induced generalised non-bullous fixed drug eruption. ( 29866687 )
2018
3
Fixed drug eruption caused by drinking alcohol. ( 29920750 )
2018
4
Fixed drug eruption associated with aspirin. ( 29550757 )
2018
5
Sparfloxacin-induced nail pigmentation: A case of fixed drug eruption? ( 29363635 )
2018
6
Mucosal fixed drug eruption due to mefenamic acid: Report of a case and a review. ( 29525693 )
2018
7
Fixed drug eruption due To 2,3-dimercapto-1-propanesulfonic acid (DMPS) treatment for mercury poisoning: a rare adverse effect. ( 29912651 )
2018
8
Occupational fixed drug eruption with ipe wood. ( 29766517 )
2018
9
Fixed Drug Eruption Due to Lorazepam. ( 29939135 )
2018
10
Fixed Drug Eruption to Cetirizine: An Unusual Villain. ( 29441302 )
2018
11
Mesalazine-induced bullous fixed drug eruption. ( 29446099 )
2018
12
Comments on Ben Mansour et al: Additional cases of multifocal fixed drug eruption to ceftazidime. ( 29537668 )
2018
13
Antituberculosis Drug-Induced Fixed Drug Eruption: A Case Report. ( 29785553 )
2018
14
Generalized fixed drug eruption to piperacillin/tazobactam and review of literature. ( 29906010 )
2018
15
Generalized Fixed Drug Eruption Induced by Fluconazole Without Cross-Reactivity to Itraconazole: Lymphocyte Transformation Test Confirms the Diagnosis. ( 29294202 )
2018
16
Fixed drug eruption to nimesulide: an exuberant presentation confirmed by patch testing. ( 29924254 )
2018
17
Fixed Drug Eruption Related to Cefixime in an Adolescent Case. ( 29339130 )
2018
18
Changing trends in inducer drugs of fixed drug eruption: a 20-year cross-sectional study from Turkey. ( 29512939 )
2018
19
Generalized bullous fixed drug eruption imitating toxic epidermal necrolysis: a case report and literature review. ( 29469697 )
2017
20
Non-pigmenting fixed drug eruption with mixed features of acute generalized exanthematous pustulosis induced by pseudoephedrine: a case report. ( 28703347 )
2017
21
Autoimmune progesterone dermatitis mimicking fixed drug eruption. ( 28084691 )
2017
22
Autoimmune progesterone dermatitis presenting as fixed drug eruption: a case report. ( 28633739 )
2017
23
Fixed Drug Eruption to Supplement Containing Ginkgo Biloba and Vinpocetine: A Case Report and Review of Related Cutaneous Side Effects. ( 29344321 )
2017
24
Ipilimumab-Induced Polyneuropathy; Ibuprofen-Induced Allergic-Type Liver Injury; Trimethoprim-Sulfamethoxazole-Induced Immune Thrombocytopenia in Children; Mesna-Induced Fixed Drug Eruption; Digoxin-Induced Ocular Toxicity. ( 27698499 )
2016
25
Autoimmune progesterone dermatitis that changed its clinical manifestation from anaphylaxis to fixed drug eruption-like erythema. ( 24750448 )
2014
26
Generalized bullous fixed drug eruption is distinct from Stevens-Johnson syndrome/toxic epidermal necrolysis by immunohistopathological features. ( 24388722 )
2014
27
Prognosis of generalized bullous fixed drug eruption: comparison with Stevens-Johnson syndrome and toxic epidermal necrolysis. ( 23413807 )
2013
28
Multifocal, fixed-drug eruption masquerading as recurrent erythema multiforme. ( 22270210 )
2012
29
Fluconazole-induced fixed drug eruption imitating herpes labialis with erythema multiforme. ( 22858871 )
2012
30
A challenging case: Symmetrical drug related intertriginous and flexural exanthem, fixed drug eruption, or both? ( 22082466 )
2011
31
Acetaminophen-induced cellulitis-like fixed drug eruption. ( 21716550 )
2011
32
Nonpigmenting fixed drug eruption as a possible abortive variant of toxic epidermal necrolysis: immunohistochemical and serum cytokine analyses. ( 19874369 )
2010
33
Case of autoimmune progesterone dermatitis presenting as fixed drug eruption. ( 19958448 )
2009
34
Possible role of Fas/Fas ligand-mediated apoptosis in the pathogenesis of fixed drug eruption. ( 16445769 )
2006
35
A case of a fixed drug eruption presenting with a butterfly rash-like exanthem in a patient with SjAPgren's syndrome. ( 15807744 )
2005
36
IFN-gamma-producing effector CD8+ T cells and IL-10-producing regulatory CD4+ T cells in fixed drug eruption. ( 13679823 )
2003
37
Multifocal bullous fixed drug eruption mimicking Stevens-Johnson syndrome. ( 17656930 )
2002
38
Direct evidence for interferon-gamma production by effector-memory-type intraepidermal T cells residing at an effector site of immunopathology in fixed drug eruption. ( 12368207 )
2002
39
Multifocal fixed drug eruption to paracetamol, tropisetron and ondansetron induced by interleukin 2. ( 11053919 )
2000
40
Papular fixed drug eruption mimicking folliculitis due to acetominophen. ( 10819605 )
2000
41
Fixed-drug eruption presenting as an acute paronychia. ( 1836953 )
1991
42
Balanitis as a fixed drug eruption to tetracycline. ( 3158749 )
1985
43
Balanitis due to fixed drug eruption associated with tetracycline therapy. ( 4251608 )
1971
44
Dermatitis herpetiformis; prurigo nodularis; fixed drug eruption (phenolphthalein). ( 14884719 )
1952
45
Fixed drug eruption and epididymitis due to antipyrine. ( 14922964 )
1952
46
Fixed drug eruption and epididymitis due to antipyrine. ( 14856412 )
1951

Variations for Fixed Drug Eruption

Expression for Fixed Drug Eruption

Search GEO for disease gene expression data for Fixed Drug Eruption.

Pathways for Fixed Drug Eruption

Pathways related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 CASP3 CCR4 CCR7 CD27 IFNG IL2
2
Show member pathways
12.95 CASP3 CCR4 CCR7 CD27 IL2
3
Show member pathways
12.83 CASP3 CCR4 CCR7 CD27 IL2
4
Show member pathways
12.33 CASP3 CD27 IFNG
5
Show member pathways
12.16 CASP3 IFNG IL2
6 11.58 CASP3 IFNG IL2
7 11.4 IFNG IL2
8
Show member pathways
11.38 IFNG IL2
9
Show member pathways
11.35 IFNG IL2
10 11.26 IFNG IL2
11 11.22 IFNG IL2
12
Show member pathways
11.21 CASP3 IFNG IL2
13 11.19 IFNG IL2
14 11.01 IFNG IL2
15 11 IFNG IL2 SELL
16 10.99 CCR7 IFNG IL2 SELL
17 10.95 IFNG IL2
18 10.9 IFNG IL2
19 10.85 IFNG IL2

GO Terms for Fixed Drug Eruption

Cellular components related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CCR4 CCR7 CD27 SELL

Biological processes related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 inflammatory response GO:0006954 9.67 CCR4 CCR7 CD27
2 chemokine-mediated signaling pathway GO:0070098 9.54 CCR4 CCR7
3 response to lipopolysaccharide GO:0032496 9.54 CASP3 CCR7 CD27
4 positive regulation of JNK cascade GO:0046330 9.52 CCR7 CD27
5 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.51 IFNG IL2
6 extrinsic apoptotic signaling pathway GO:0097191 9.48 CD27 IFNG
7 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.46 CASP3 IL2
8 response to antibiotic GO:0046677 9.43 CASP3 CCR4
9 positive regulation of interleukin-12 production GO:0032735 9.4 CCR7 IFNG
10 homeostasis of number of cells GO:0048872 9.32 CCR4 CCR7
11 positive regulation of T cell differentiation GO:0045582 9.26 CD27 IL2
12 regulation of regulatory T cell differentiation GO:0045589 9.16 IFNG IL2
13 positive regulation of cytosolic calcium ion concentration GO:0007204 9.13 CCR4 CCR7 IL2
14 immune response GO:0006955 9.02 CCR4 CCR7 CD27 IFNG IL2

Molecular functions related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine receptor activity GO:0004950 9.16 CCR4 CCR7
2 C-C chemokine receptor activity GO:0016493 8.96 CCR4 CCR7
3 glycosphingolipid binding GO:0043208 8.62 IL2 SELL

Sources for Fixed Drug Eruption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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