MCID: FXD003
MIFTS: 40

Fixed Drug Eruption

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Fixed Drug Eruption

MalaCards integrated aliases for Fixed Drug Eruption:

Name: Fixed Drug Eruption 60 74

Characteristics:

Orphanet epidemiological data:

60
fixed drug eruption
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: All ages;

Classifications:

Orphanet: 60  
Rare skin diseases


External Ids:

UMLS via Orphanet 75 C0877391
Orphanet 60 ORPHA293812
UMLS 74 C0221242

Summaries for Fixed Drug Eruption

MalaCards based summary : Fixed Drug Eruption is related to erythema multiforme and stevens-johnson syndrome/toxic epidermal necrolysis, and has symptoms including integumentary system signs and symptoms An important gene associated with Fixed Drug Eruption is CCR7 (C-C Motif Chemokine Receptor 7), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drug Petrolatum has been mentioned in the context of this disorder. Affiliated tissues include testes, t cells and skin, and related phenotypes are cellular and hematopoietic system

Related Diseases for Fixed Drug Eruption

Diseases related to Fixed Drug Eruption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 erythema multiforme 30.3 IFNG IL2
2 stevens-johnson syndrome/toxic epidermal necrolysis 29.8 IFNG IL2
3 cutaneous t cell lymphoma 29.4 CCR4 IFNG IL2
4 dermatitis 10.3
5 severe cutaneous adverse reaction 10.3
6 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.3
7 pars planitis 10.2 CCR7 CD27
8 autoimmune progesterone dermatitis 10.2
9 lower lip cancer 10.2 CASP3 IL2
10 herpes simplex 10.2
11 influenza 10.1
12 variola major 10.1 IFNG IL2
13 leukocyte disease 10.1 CASP3 IL2
14 berylliosis 10.1 IFNG IL2
15 atopic keratoconjunctivitis 10.1 IFNG IL2
16 keratoconjunctivitis 10.1 IFNG IL2
17 conjunctivitis 10.1 IFNG IL2
18 clonorchiasis 10.0 IFNG IL2
19 crohn's colitis 10.0 IFNG IL2
20 chronic active epstein-barr virus infection 10.0 IFNG IL2
21 intermediate uveitis 10.0 IFNG IL2
22 posterior uveitis 10.0 IFNG IL2
23 coccidiosis 10.0 IFNG IL2
24 hematopoietic stem cell transplantation 10.0 IFNG IL2
25 vernal conjunctivitis 10.0 IFNG IL2
26 autoimmune disease of endocrine system 10.0 IFNG IL2
27 hypersensitivity reaction type iv disease 10.0 IFNG IL2
28 leprosy 3 10.0 IFNG IL2
29 acute graft versus host disease 10.0 IFNG IL2
30 lepromatous leprosy 10.0 IFNG IL2
31 autoimmune uveitis 10.0 IFNG IL2
32 burns 10.0
33 hepatitis 10.0
34 exanthem 10.0
35 balanitis 10.0
36 cellulitis 10.0
37 bullous pemphigoid 10.0
38 vasculitis 10.0
39 paracoccidioidomycosis 10.0 IFNG IL2
40 testicular disease 10.0 IFNG IL2
41 herpes zoster 10.0 IFNG IL2
42 brucellosis 10.0 IFNG IL2
43 tropical spastic paraparesis 10.0 IFNG IL2
44 human immunodeficiency virus infectious disease 10.0 IFNG IL2
45 tonsillitis 10.0 IFNG IL2
46 smallpox 10.0 IFNG IL2
47 mumps 10.0 IFNG IL2
48 parasitic protozoa infectious disease 10.0 IFNG IL2
49 filariasis 10.0 IFNG IL2
50 alopecia areata 10.0 IFNG IL2

Graphical network of the top 20 diseases related to Fixed Drug Eruption:



Diseases related to Fixed Drug Eruption

Symptoms & Phenotypes for Fixed Drug Eruption

UMLS symptoms related to Fixed Drug Eruption:


integumentary system signs and symptoms

MGI Mouse Phenotypes related to Fixed Drug Eruption:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 CASP3 CCR7 CD27 IFNG IL2 SELL
2 hematopoietic system MP:0005397 9.7 CASP3 CCR4 CCR7 CD27 IFNG IL2
3 endocrine/exocrine gland MP:0005379 9.65 CASP3 CCR7 IFNG IL2 SELL
4 immune system MP:0005387 9.5 CASP3 CCR4 CCR7 CD27 IFNG IL2
5 respiratory system MP:0005388 9.02 CASP3 CCR4 IFNG IL2 SELL

Drugs & Therapeutics for Fixed Drug Eruption

Drugs for Fixed Drug Eruption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Petrolatum Approved, Investigational Not Applicable 8009-03-8

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Drug Patch Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs) Recruiting NCT03176342 Not Applicable
2 Severe Cutaneous Adverse Reactions in Thailand Recruiting NCT02574988

Search NIH Clinical Center for Fixed Drug Eruption

Genetic Tests for Fixed Drug Eruption

Anatomical Context for Fixed Drug Eruption

MalaCards organs/tissues related to Fixed Drug Eruption:

42
Testes, T Cells, Skin, Liver, Tongue, Neutrophil, Breast

Publications for Fixed Drug Eruption

Articles related to Fixed Drug Eruption:

(show top 50) (show all 662)
# Title Authors Year
1
Generalized fixed drug eruption mimicking CD8+ cutaneous T-cell lymphoma in HIV. ( 30328131 )
2019
2
Fixed drug eruption due To 2,3-dimercapto-1-propanesulfonic acid (DMPS) treatment for mercury poisoning: a rare adverse effect. ( 29912651 )
2019
3
Fixed drug eruption caused by drinking alcohol. ( 29920750 )
2019
4
Norfloxacin Induced Recurrent Fixed Drug Eruption in a self Treated Adult Female Patient - A Case Report. ( 30084337 )
2019
5
Neutrophilic fixed drug eruption: a mimic of neutrophilic dermatoses. ( 30198122 )
2019
6
Fixed Drug Eruption Due to Chlorhexidine Mouthwash Confirmed by Lesional Patch Testing. ( 30205946 )
2019
7
A case report of fixed drug eruption caused by several drugs because of cross-reactivity and co-sensitization. ( 30246872 )
2019
8
Fixed drug eruption caused by fluconazole-An underdiagnosed but recurrent problem. ( 30417394 )
2019
9
A case of entecavir-associated bullous fixed drug eruption and a review of literature. ( 30459136 )
2019
10
Fixed drug eruption caused by fulvestrant confirmed by skin tests: First case. ( 30461027 )
2019
11
Lentigines within fixed drug eruption: reply to 'Multiple lentigines arising on resolving psoriatic plaques after treatment with apremilast'. ( 30575106 )
2019
12
Piroxicam-induced fixed drug eruption: Cross-reactivity with meloxicam. ( 30663057 )
2019
13
Bullous Fixed Drug Eruption Caused by Etoricoxib Confirmed by Patch Testing. ( 30777670 )
2019
14
Herpes Simplex-Like Fixed Drug Eruption Induced by Fluconazole Without Cross-reactivity to Itraconazole. ( 30829805 )
2019
15
Fixed drug eruption on the tongue associated with piroxicam: report of two cases and literature review. ( 30853413 )
2019
16
Fixed drug eruption caused by antibiotics contained in food? ( 30900776 )
2019
17
S-Carboxymethyl-L-cysteine-induced Fixed Drug Eruption. ( 30938829 )
2019
18
Bullous fixed drug eruption: A potential diagnostic pitfall: a study of 18 cases. ( 31006486 )
2019
19
Fixed drug eruption due to itraconazole: a rare occurence. ( 31085618 )
2019
20
Can a single drug administration elicit two different immunological pathways at the same time? Fixed drug eruption after anaphylaxis. ( 29192468 )
2019
21
Autoimmune progesterone dermatitis manifesting as generalized fixed drug eruption. ( 30484533 )
2018
22
Multifocal fixed drug eruption to ceftazidime in a child with cystic fibrosis. ( 29047164 )
2018
23
Bullous artificial dermatitis due to aerosol sprays masquerading as fixed drug eruption. ( 30565292 )
2018
24
Fixed drug eruption associated with aspirin. ( 29550757 )
2018
25
Bullous Fixed Drug Eruption Following Ibuprofen Ingestion. ( 29756000 )
2018
26
Occupational fixed drug eruption with ipe wood. ( 29766517 )
2018
27
Antituberculosis Drug-Induced Fixed Drug Eruption: A Case Report. ( 29785553 )
2018
28
Ciprofloxacin-induced generalised non-bullous fixed drug eruption. ( 29866687 )
2018
29
Generalized fixed drug eruption to piperacillin/tazobactam and review of literature. ( 29906010 )
2018
30
Fixed drug eruption to nimesulide: an exuberant presentation confirmed by patch testing. ( 29924254 )
2018
31
Fixed Drug Eruption Due to Lorazepam. ( 29939135 )
2018
32
Bullous Fixed Drug Eruption Caused by Doxycycline. ( 29989543 )
2018
33
Non-pigmenting Fixed Drug Eruption: An Unusual Adverse Reaction to Aceclofenac. ( 30047334 )
2018
34
Cetirizine-Induced Fixed Drug Eruption. ( 30050965 )
2018
35
Local desensitization and progression of multiple fixed drug eruption. ( 30105994 )
2018
36
Fixed drug eruption related to sunitinib: a case report. ( 30142719 )
2018
37
Pheniramine maleate: an apparently safe drug causing bullous fixed drug eruption. ( 30142724 )
2018
38
Ivermectin-induced fixed drug eruption in an elderly Cameroonian: a case report. ( 30201032 )
2018
39
Cyclosporine in Generalized Bullous-Fixed Drug Eruption. ( 30210171 )
2018
40
Paracetamol-induced fixed drug eruption presenting as eyelid skin necrosis. ( 30355885 )
2018
41
Cefotaxime induced generalized bullous fixed drug eruption - A case report. ( 30364669 )
2018
42
Generalized bullous fixed-drug eruption secondary to the influenza vaccine. ( 30364778 )
2018
43
Generalized bullous fixed drug eruption caused by ibuprofen. ( 30430598 )
2018
44
ISMP Adverse Drug Reactions: Lithium-Induced Cardiomyopathy Fixed Drug Eruption Due to Cetirizine, Levocetirizine, and Hydroxyzine Nivolumab-Induced Myasthenia Gravis Nivolumab-Induced Cholangitic Liver Disease Torsade de Pointes Caused by Psychiatric Polypharmacy Trichotillomania Associated With Aripiprazole. ( 30559522 )
2018
45
A Probable Case of Mucosal Fixed Drug Eruption Following Treatment with Silodosin. ( 30607288 )
2018
46
Bullous Fixed Drug Eruption Secondary to Chlorthalidone. ( 28811176 )
2018
47
Generalized Bullous Fixed Drug Eruption Following Metamizole (Re-)Exposure: A Medical Error-analytic Case Study. ( 29136265 )
2018
48
Generalized Fixed Drug Eruption Induced by Fluconazole Without Cross-Reactivity to Itraconazole: Lymphocyte Transformation Test Confirms the Diagnosis. ( 29294202 )
2018
49
Fixed Drug Eruption Related to Cefixime in an Adolescent Case. ( 29339130 )
2018
50
Sparfloxacin-induced nail pigmentation: A case of fixed drug eruption? ( 29363635 )
2018

Variations for Fixed Drug Eruption

Expression for Fixed Drug Eruption

Search GEO for disease gene expression data for Fixed Drug Eruption.

Pathways for Fixed Drug Eruption

Pathways related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 CASP3 CCR4 CCR7 CD27 IFNG IL2
2
Show member pathways
13.01 CASP3 CD27 IFNG IL2
3
Show member pathways
12.95 CASP3 CCR4 CCR7 CD27 IL2
4
Show member pathways
12.83 CASP3 CCR4 CCR7 CD27 IL2
5
Show member pathways
12.36 CASP3 CD27 IFNG
6
Show member pathways
12.16 CASP3 IFNG IL2
7 11.58 CASP3 IFNG IL2
8 11.44 IFNG IL2
9 11.4 IFNG IL2
10
Show member pathways
11.37 IFNG IL2
11
Show member pathways
11.34 IFNG IL2
12 11.26 IFNG IL2
13 11.22 IFNG IL2
14
Show member pathways
11.21 CASP3 IFNG IL2
15 11.19 IFNG IL2
16 11.01 IFNG IL2
17 11 IFNG IL2 SELL
18 10.99 CCR7 IFNG IL2 SELL
19 10.94 IFNG IL2
20 10.9 IFNG IL2
21 10.85 IFNG IL2

GO Terms for Fixed Drug Eruption

Cellular components related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CCR4 CCR7 CD27 SELL

Biological processes related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 chemokine-mediated signaling pathway GO:0070098 9.49 CCR4 CCR7
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.48 IFNG IL2
3 extrinsic apoptotic signaling pathway GO:0097191 9.46 CD27 IFNG
4 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 CASP3 IL2
5 response to antibiotic GO:0046677 9.4 CASP3 CCR4
6 positive regulation of interleukin-12 production GO:0032735 9.37 CCR7 IFNG
7 homeostasis of number of cells GO:0048872 9.32 CCR4 CCR7
8 positive regulation of T cell differentiation GO:0045582 9.26 CD27 IL2
9 regulation of regulatory T cell differentiation GO:0045589 9.16 IFNG IL2
10 positive regulation of cytosolic calcium ion concentration GO:0007204 9.13 CCR4 CCR7 IL2
11 immune response GO:0006955 8.92 CCR4 CCR7 IFNG IL2

Molecular functions related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine binding GO:0019956 9.32 CCR4 CCR7
2 C-C chemokine binding GO:0019957 9.26 CCR4 CCR7
3 C-C chemokine receptor activity GO:0016493 9.16 CCR4 CCR7
4 chemokine receptor activity GO:0004950 8.96 CCR4 CCR7
5 glycosphingolipid binding GO:0043208 8.62 IL2 SELL

Sources for Fixed Drug Eruption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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