MCID: FXD003
MIFTS: 34

Fixed Drug Eruption

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Fixed Drug Eruption

MalaCards integrated aliases for Fixed Drug Eruption:

Name: Fixed Drug Eruption 58 71

Characteristics:

Orphanet epidemiological data:

58
fixed drug eruption
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

UMLS via Orphanet 72 C0877391
Orphanet 58 ORPHA293812
UMLS 71 C0221242

Summaries for Fixed Drug Eruption

MalaCards based summary : Fixed Drug Eruption is related to erythema multiforme and stevens-johnson syndrome/toxic epidermal necrolysis, and has symptoms including integumentary system signs and symptoms An important gene associated with Fixed Drug Eruption is CASP3 (Caspase 3), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include t cells, tongue and eye, and related phenotypes are cellular and hematopoietic system

Related Diseases for Fixed Drug Eruption

Diseases related to Fixed Drug Eruption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 221)
# Related Disease Score Top Affiliating Genes
1 erythema multiforme 30.8 IL2 IFNG
2 stevens-johnson syndrome/toxic epidermal necrolysis 30.7 IL2 IFNG
3 exanthem 30.6 IL2 IFNG
4 dermatitis 30.3 IL2 IFNG CCR4
5 erythema nodosum 29.9 SELL IFNG
6 allergic disease 29.9 IL2 IFNG CD27
7 allergic conjunctivitis 29.7 IL2 IFNG
8 pelvic inflammatory disease 29.5 IL2 IFNG
9 cutaneous t cell lymphoma 29.4 IL2 IFNG CCR4
10 filariasis 29.3 IL2 IFNG CD27
11 contact dermatitis 29.1 SELL IL2 IFNG CCR7 CCR4
12 mycosis fungoides 29.1 IL2 IFNG CCR7 CCR4
13 thrombocytopenia 29.0 SELL IL2 IFNG CASP3
14 dowling-degos disease 1 10.7
15 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.6
16 severe cutaneous adverse reaction 10.6
17 erythema multiforme major 10.6
18 urticaria 10.4
19 progestogen hypersensitivity 10.4
20 drug allergy 10.4
21 skin disease 10.3
22 herpes simplex 10.3
23 common cold 10.3
24 candidiasis 10.3
25 cellulitis 10.3
26 vasculitis 10.3
27 angioedema 10.2
28 rhinitis 10.2
29 parapsoriasis 10.2
30 lichen planus 10.2
31 renal cell carcinoma, nonpapillary 10.1
32 migraine with or without aura 1 10.1
33 leprosy 3 10.1
34 prostatic hyperplasia, benign 10.1
35 allergic rhinitis 10.1
36 hepatitis c virus 10.1
37 pemphigoid 10.1
38 prostatic hypertrophy 10.1
39 balanitis 10.1
40 paronychia 10.1
41 diarrhea 10.1
42 impotence 10.1
43 prostatic adenoma 10.1
44 purpura 10.1
45 vulvitis 10.1
46 bronchitis 10.1
47 bullous pemphigoid 10.1
48 hansen's disease 10.1
49 acute generalized exanthematous pustulosis 10.1
50 spotted fever 10.1 IFNG CASP3

Graphical network of the top 20 diseases related to Fixed Drug Eruption:



Diseases related to Fixed Drug Eruption

Symptoms & Phenotypes for Fixed Drug Eruption

UMLS symptoms related to Fixed Drug Eruption:


integumentary system signs and symptoms

MGI Mouse Phenotypes related to Fixed Drug Eruption:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 CASP3 CCR7 CD27 IFNG IL2 SELL
2 hematopoietic system MP:0005397 9.7 CASP3 CCR4 CCR7 CD27 IFNG IL2
3 immune system MP:0005387 9.5 CASP3 CCR4 CCR7 CD27 IFNG IL2
4 respiratory system MP:0005388 9.02 CASP3 CCR4 IFNG IL2 SELL

Drugs & Therapeutics for Fixed Drug Eruption

Search Clinical Trials , NIH Clinical Center for Fixed Drug Eruption

Genetic Tests for Fixed Drug Eruption

Anatomical Context for Fixed Drug Eruption

MalaCards organs/tissues related to Fixed Drug Eruption:

40
T Cells, Tongue, Eye, Myeloid

Publications for Fixed Drug Eruption

Articles related to Fixed Drug Eruption:

(show top 50) (show all 917)
# Title Authors PMID Year
1
Fixed drug eruption secondary to adalimumab. 61
33448464 2021
2
Fixed drug eruption due to bismuth during Helicobacter pylori eradication therapy. 61
33545396 2021
3
Fixed drug eruption and anaphylaxis induced concurrently by erdosteine: a case report. 61
33546741 2021
4
The Role of In Vivo and Ex Vivo Diagnostic Tools in Severe Delayed Immune-Mediated Adverse Antibiotic Drug Reactions. 61
33453452 2021
5
Amlodipine-induced generalized fixed drug eruption clinically mimicking mycosis fungoides. 61
33433038 2021
6
Fixed drug eruption: A new side effect of bromelain. 61
32648609 2021
7
Hydroxypropyl cellulose-induced fixed drug eruption as an adverse effect of generic drugs. 61
33460455 2021
8
Ustekinumab-induced fixed drug eruption. 61
33294551 2020
9
Levofloxacin induced bullous fixed drug eruption: a rare case report. 61
33355292 2020
10
Probable etoricoxib-induced fixed drug eruption involving the oral mucosa: A case report. 61
33468439 2020
11
Fluconazole-induced fixed drug eruption confirmed by extemporaneous patch testing. 61
32542690 2020
12
Fixed drug eruption dramatically exacerbated during treatment with programmed death 1 inhibitor. 61
32860236 2020
13
Autoimmune progesterone dermatitis in the adolescent population. 61
33368681 2020
14
First report of tamoxifen-induced baboon syndrome. 61
33253493 2020
15
Bullous fixed drug eruption following Human Papilloma Virus vaccination. 61
32181534 2020
16
Ibuprofen-induced generalised bullous fixed drug eruption. 61
32001485 2020
17
Fixed drug eruption to Serenoa repens: First case report and consideration of the use of herbal medicine. 61
32860310 2020
18
Bullous fixed drug eruption induced by fluconazole: Importance of multi-site lesional patch testing. 61
33210283 2020
19
Might your gin tonic make you sick? Fixed drug eruption likely due to quinine in gin tonic. 61
32383255 2020
20
Atypical bullous dermatosis: from suspected drug reaction to misdiagnosed occult epilepsy. Two challenging cases. 61
33091119 2020
21
Detecting Lesional Granulysin Levels for Rapid Diagnosis of Cytotoxic T lymphocyte-Mediated Bullous Skin Disorders. 61
33039642 2020
22
Multilocular bullous fixed drug eruption elicited by paracetamol and migraine attacks, but not by paracetamol alone. 61
32314407 2020
23
Bullous fixed drug eruption related to multivitamins. 61
33054952 2020
24
A case of fixed drug eruption induced by doxycycline, mimicking a symmetrical drug-related intertriginous and flexural exanthema (SDRIFE). 61
31761151 2020
25
Fixed drug eruption to rupatadine with positive patch tests on non-lesional skin. 61
32342508 2020
26
Fixed drug eruption due to norfloxacin with cross-reactivity to ciprofloxacin: A case report. 61
32243605 2020
27
Acetaminophen-induced generalized fixed drug eruption in a 5-year-old girl. 61
32285521 2020
28
Fixed drug eruption (FDE) induced by mefenamic acid with unusually cross-reactivity to diclofenac: A case report. 61
32632965 2020
29
Generalized bullous fixed drug eruption successfully treated with cyclosporine. 61
32356595 2020
30
Fixed Drug Eruption to Palm Wine: A Case. 61
32832463 2020
31
Etoricoxib-induced fixed drug eruption: Report of seven cases. 61
32666601 2020
32
Fixed Drug Eruptions: An Update, Emphasizing the Potentially Lethal Generalized Bullous Fixed Drug Eruption. 61
32002848 2020
33
A first case of fixed drug eruption due to Tamsulosin. 61
31541583 2020
34
Esomeprazole fixed drug eruption. 61
31967328 2020
35
Desquamating Nonpigmenting Fixed Drug Eruption With Onycholysis due to Amoxicillin in a Child: Cross-reactivity Study. 61
31751290 2020
36
Multiple widespread fixed drug eruption caused by rabeprazole. 61
32270780 2020
37
Generalized bullous fixed drug eruption: Trazodone as a new culprit. 61
31742734 2020
38
When a Gin Tonic Can Mean Trouble: Fixed Drug Eruption Due to Quinine. 61
31879027 2020
39
Loxoprofen-induced bullous fixed drug eruption. 61
32161698 2020
40
Hypersensitivity reactions to proton-pump inhibitors: Clinical presentation, diagnosis, and management. 61
32122452 2020
41
Case of autoimmune progesterone dermatitis presenting as necrotic migratory erythema successfully controlled by danazol. 61
31829458 2020
42
Successful desensitization to metronidazole in a patient with generalized fixed drug eruption. 61
31369825 2020
43
Co-occurrence of Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE) and Pigmented Fixed Drug Eruption (FDE) in a Single Patient Due to Doxycycline: A Case Report. 61
32055511 2020
44
Fixed Drug Eruption of the Tongue Due to Trimethoprim-Sulfamethoxazole. 61
31519543 2020
45
Fixed Drug Eruption on the Tongue Due to Naproxen. 61
32131994 2020
46
Multiple Fixed Drug Eruption Mimicking Parapsoriasis en Plaque in a Patient with Hepatitis C Virus Infection. 61
32110206 2020
47
Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders. 61
31595056 2020
48
Loss of tolerance 5 days after discontinuing sulphonamide introduced via desensitization in delayed reaction. 61
31778467 2020
49
Evaluation of Subjects Experiencing Allergic Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Characteristics and Drugs Involved. 61
32425774 2020
50
Fixed drug eruption caused by allylisopropylacetylurea mimicking contact dermatitis of the face. 61
31400018 2020

Variations for Fixed Drug Eruption

Expression for Fixed Drug Eruption

Search GEO for disease gene expression data for Fixed Drug Eruption.

Pathways for Fixed Drug Eruption

Pathways related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 IL2 CD27 CCR7 CCR4 CASP3
2
Show member pathways
13.07 IL2 IFNG CD27 CCR7 CCR4 CASP3
3
Show member pathways
12.95 IL2 CD27 CCR7 CCR4 CASP3
4
Show member pathways
12.79 IL2 CD27 CCR7 CCR4 CASP3
5
Show member pathways
12.35 IFNG CD27 CASP3
6
Show member pathways
12.19 IL2 IFNG CASP3
7
Show member pathways
11.94 IL2 CCR7 CCR4
8 11.62 IL2 IFNG CASP3
9 11.42 IL2 IFNG
10
Show member pathways
11.4 IL2 IFNG
11
Show member pathways
11.37 IL2 IFNG
12 11.27 IL2 IFNG
13 11.24 IL2 IFNG
14 11.21 IL2 IFNG
15
Show member pathways
11.21 IL2 IFNG CASP3
16
Show member pathways
11.08 IL2 IFNG
17 11.03 IL2 IFNG
18 11 SELL IL2 IFNG
19 10.99 SELL IL2 IFNG CCR7
20 10.96 IL2 IFNG
21 10.92 IL2 IFNG
22 10.87 IL2 IFNG

GO Terms for Fixed Drug Eruption

Cellular components related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.8 CD27 CCR7 CCR4

Biological processes related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extrinsic apoptotic signaling pathway GO:0097191 9.48 IFNG CD27
2 positive regulation of interleukin-12 production GO:0032735 9.46 IFNG CCR7
3 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 IL2 CASP3
4 response to antibiotic GO:0046677 9.4 CCR4 CASP3
5 homeostasis of number of cells GO:0048872 9.37 CCR7 CCR4
6 positive regulation of amyloid-beta formation GO:1902004 9.32 IFNG CASP3
7 positive regulation of T cell differentiation GO:0045582 9.26 IL2 CD27
8 regulation of regulatory T cell differentiation GO:0045589 9.16 IL2 IFNG
9 positive regulation of cytosolic calcium ion concentration GO:0007204 9.13 IL2 CCR7 CCR4
10 immune response GO:0006955 8.92 IL2 IFNG CCR7 CCR4

Molecular functions related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 C-C chemokine binding GO:0019957 9.26 CCR7 CCR4
2 C-C chemokine receptor activity GO:0016493 9.16 CCR7 CCR4
3 chemokine receptor activity GO:0004950 8.96 CCR7 CCR4
4 glycosphingolipid binding GO:0043208 8.62 SELL IL2

Sources for Fixed Drug Eruption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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