MCID: FXD003
MIFTS: 38

Fixed Drug Eruption

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Fixed Drug Eruption

MalaCards integrated aliases for Fixed Drug Eruption:

Name: Fixed Drug Eruption 59 73

Characteristics:

Orphanet epidemiological data:

59
fixed drug eruption
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

Orphanet 59 ORPHA293812
UMLS via Orphanet 74 C0877391
UMLS 73 C0221242

Summaries for Fixed Drug Eruption

MalaCards based summary : Fixed Drug Eruption is related to erythema multiforme and stevens-johnson syndrome/toxic epidermal necrolysis, and has symptoms including integumentary system signs and symptoms An important gene associated with Fixed Drug Eruption is CD27 (CD27 Molecule), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. The drug Petrolatum has been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related phenotypes are cellular and hematopoietic system

Related Diseases for Fixed Drug Eruption

Diseases related to Fixed Drug Eruption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 108)
# Related Disease Score Top Affiliating Genes
1 erythema multiforme 30.3 IFNG IL2
2 stevens-johnson syndrome/toxic epidermal necrolysis 29.8 IFNG IL2
3 cutaneous t cell lymphoma 29.6 CCR4 IFNG IL2
4 dermatitis 10.3
5 severe cutaneous adverse reaction 10.2
6 autoimmune progesterone dermatitis 10.2
7 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.2
8 pars planitis 10.2 CCR7 CD27
9 lower lip cancer 10.1 CASP3 IL2
10 influenza 10.1
11 herpes simplex 10.1
12 variola major 10.0 IFNG IL2
13 berylliosis 10.0 IFNG IL2
14 atopic keratoconjunctivitis 10.0 IFNG IL2
15 keratoconjunctivitis 10.0 IFNG IL2
16 conjunctivitis 10.0 IFNG IL2
17 clonorchiasis 10.0 IFNG IL2
18 crohn's colitis 10.0 IFNG IL2
19 chronic active epstein-barr virus infection 10.0 IFNG IL2
20 leukocyte disease 10.0 CASP3 IL2
21 intermediate uveitis 10.0 IFNG IL2
22 posterior uveitis 10.0 IFNG IL2
23 coccidiosis 10.0 IFNG IL2
24 hematopoietic stem cell transplantation 10.0 IFNG IL2
25 vernal conjunctivitis 10.0 IFNG IL2
26 autoimmune disease of endocrine system 10.0 IFNG IL2
27 hypersensitivity reaction type iv disease 10.0 IFNG IL2
28 acute graft versus host disease 10.0 IFNG IL2
29 lepromatous leprosy 10.0 IFNG IL2
30 autoimmune uveitis 10.0 IFNG IL2
31 paracoccidioidomycosis 10.0 IFNG IL2
32 testicular disease 10.0 IFNG IL2
33 herpes zoster 10.0 IFNG IL2
34 brucellosis 10.0 IFNG IL2
35 tropical spastic paraparesis 10.0 IFNG IL2
36 human immunodeficiency virus infectious disease 10.0 IFNG IL2
37 tonsillitis 10.0 IFNG IL2
38 hepatitis 10.0
39 exanthem 10.0
40 balanitis 10.0
41 cellulitis 10.0
42 bullous pemphigoid 10.0
43 vasculitis 10.0
44 epididymitis 10.0
45 smallpox 10.0 IFNG IL2
46 mumps 10.0 IFNG IL2
47 parasitic protozoa infectious disease 10.0 IFNG IL2
48 leprosy 3 10.0 IFNG IL2
49 filariasis 10.0 IFNG IL2
50 peripheral t-cell lymphoma 10.0 CCR4 IL2

Graphical network of the top 20 diseases related to Fixed Drug Eruption:



Diseases related to Fixed Drug Eruption

Symptoms & Phenotypes for Fixed Drug Eruption

UMLS symptoms related to Fixed Drug Eruption:


integumentary system signs and symptoms

MGI Mouse Phenotypes related to Fixed Drug Eruption:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 CASP3 CCR7 CD27 IFNG IL2 SELL
2 hematopoietic system MP:0005397 9.7 CASP3 CCR4 CCR7 CD27 IFNG IL2
3 endocrine/exocrine gland MP:0005379 9.65 CASP3 CCR7 IFNG IL2 SELL
4 immune system MP:0005387 9.5 CASP3 CCR4 CCR7 CD27 IFNG IL2
5 respiratory system MP:0005388 9.02 CASP3 CCR4 IFNG IL2 SELL

Drugs & Therapeutics for Fixed Drug Eruption

Drugs for Fixed Drug Eruption (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Petrolatum Approved, Investigational Not Applicable 8009-03-8

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Severe Cutaneous Adverse Reactions in Thailand Unknown status NCT02574988
2 Drug Patch Tests in Patients With Severe Cutaneous Adverse Reaction to Drugs (SCARs) Recruiting NCT03176342 Not Applicable

Search NIH Clinical Center for Fixed Drug Eruption

Genetic Tests for Fixed Drug Eruption

Anatomical Context for Fixed Drug Eruption

MalaCards organs/tissues related to Fixed Drug Eruption:

41
Testes, Skin, T Cells, Bone, Tonsil, B Cells, Monocytes

Publications for Fixed Drug Eruption

Articles related to Fixed Drug Eruption:

(show top 50) (show all 650)
# Title Authors Year
1
A case report of fixed drug eruption caused by several drugs because of cross-reactivity and co-sensitization. ( 30246872 )
2019
2
Bullous Fixed Drug Eruption Following Ibuprofen Ingestion. ( 29756000 )
2018
3
Ciprofloxacin-induced generalised non-bullous fixed drug eruption. ( 29866687 )
2018
4
Fixed drug eruption caused by drinking alcohol. ( 29920750 )
2018
5
Fixed drug eruption associated with aspirin. ( 29550757 )
2018
6
Sparfloxacin-induced nail pigmentation: A case of fixed drug eruption? ( 29363635 )
2018
7
Mucosal fixed drug eruption due to mefenamic acid: Report of a case and a review. ( 29525693 )
2018
8
Fixed drug eruption due To 2,3-dimercapto-1-propanesulfonic acid (DMPS) treatment for mercury poisoning: a rare adverse effect. ( 29912651 )
2018
9
Occupational fixed drug eruption with ipe wood. ( 29766517 )
2018
10
Fixed Drug Eruption Due to Lorazepam. ( 29939135 )
2018
11
Fixed Drug Eruption to Cetirizine: An Unusual Villain. ( 29441302 )
2018
12
Mesalazine-induced bullous fixed drug eruption. ( 29446099 )
2018
13
Comments on Ben Mansour et al: Additional cases of multifocal fixed drug eruption to ceftazidime. ( 29537668 )
2018
14
Antituberculosis Drug-Induced Fixed Drug Eruption: A Case Report. ( 29785553 )
2018
15
Generalized fixed drug eruption to piperacillin/tazobactam and review of literature. ( 29906010 )
2018
16
Generalized Fixed Drug Eruption Induced by Fluconazole Without Cross-Reactivity to Itraconazole: Lymphocyte Transformation Test Confirms the Diagnosis. ( 29294202 )
2018
17
Fixed drug eruption to nimesulide: an exuberant presentation confirmed by patch testing. ( 29924254 )
2018
18
Fixed Drug Eruption Related to Cefixime in an Adolescent Case. ( 29339130 )
2018
19
Autoimmune progesterone dermatitis manifesting as generalized fixed drug eruption. ( 30484533 )
2018
20
Generalized fixed drug eruption mimicking CD8+ cutaneous T-cell lymphoma in HIV. ( 30328131 )
2018
21
Generalized bullous fixed-drug eruption secondary to the influenza vaccine. ( 30364778 )
2018
22
Fixed drug eruption caused by fluconazole-An underdiagnosed but recurrent problem. ( 30417394 )
2018
23
Generalized bullous fixed drug eruption due to ibuprofen. ( 30430598 )
2018
24
A case of entecavir-associated bullous fixed drug eruption and a review of literature. ( 30459136 )
2018
25
Fixed drug eruption caused by fulvestrant confirmed by skin tests: First case. ( 30461027 )
2018
26
Bullous Fixed Drug Eruption Secondary to Chlorthalidone. ( 28811176 )
2018
27
Multifocal fixed drug eruption to ceftazidime in a child with cystic fibrosis. ( 29047164 )
2018
28
Generalized Bullous Fixed Drug Eruption Following Metamizole (Re-)Exposure: A Medical Error-analytic Case Study. ( 29136265 )
2018
29
Changing trends in inducer drugs of fixed drug eruption: a 20-year cross-sectional study from Turkey. ( 29512939 )
2018
30
Bullous Fixed Drug Eruption Caused by Doxycycline. ( 29989543 )
2018
31
Non-pigmenting Fixed Drug Eruption: An Unusual Adverse Reaction to Aceclofenac. ( 30047334 )
2018
32
Cetirizine-Induced Fixed Drug Eruption. ( 30050965 )
2018
33
Norfloxacin induced Recurrent Fixed Drug Eruption in a self treated adult female patient - A Case Report. ( 30084337 )
2018
34
Local desensitization and progression of multiple fixed drug eruption. ( 30105994 )
2018
35
Fixed drug eruption related to sunitinib: a case report. ( 30142719 )
2018
36
Pheniramine maleate: an apparently safe drug causing bullous fixed drug eruption. ( 30142724 )
2018
37
Neutrophilic fixed drug eruption: a mimic of neutrophilic dermatoses. ( 30198122 )
2018
38
Ivermectin-induced fixed drug eruption in an elderly Cameroonian: a case report. ( 30201032 )
2018
39
Fixed Drug Eruption Due to Chlorhexidine Mouthwash Confirmed by Lesional Patch Testing. ( 30205946 )
2018
40
Cyclosporine in Generalized Bullous-Fixed Drug Eruption. ( 30210171 )
2018
41
Paracetamol-induced fixed drug eruption presenting as eyelid skin necrosis. ( 30355885 )
2018
42
Cefotaxime induced generalized bullous fixed drug eruption - A case report. ( 30364669 )
2018
43
Generalized bullous fixed drug eruption imitating toxic epidermal necrolysis: a case report and literature review. ( 29469697 )
2017
44
Non-pigmenting fixed drug eruption with mixed features of acute generalized exanthematous pustulosis induced by pseudoephedrine: a case report. ( 28703347 )
2017
45
Autoimmune progesterone dermatitis mimicking fixed drug eruption. ( 28084691 )
2017
46
Autoimmune progesterone dermatitis presenting as fixed drug eruption: a case report. ( 28633739 )
2017
47
Fixed Drug Eruption to Supplement Containing Ginkgo Biloba and Vinpocetine: A Case Report and Review of Related Cutaneous Side Effects. ( 29344321 )
2017
48
Fixed drug eruption due to three antihistamines of a same chemical family: Cetirizine, levocetirizine, and hydroxyzine. ( 27612321 )
2017
49
Non-pigmenting fixed drug eruption due to fluoroquinolones. ( 27647361 )
2017
50
Metformin-Induced Generalized Fixed Drug Eruption With Cutaneous Hemophagocytosis. ( 27906695 )
2017

Variations for Fixed Drug Eruption

Expression for Fixed Drug Eruption

Search GEO for disease gene expression data for Fixed Drug Eruption.

Pathways for Fixed Drug Eruption

Pathways related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 CASP3 CCR4 CCR7 CD27 IFNG IL2
2
Show member pathways
13.01 CASP3 CD27 IFNG IL2
3
Show member pathways
12.95 CASP3 CCR4 CCR7 CD27 IL2
4
Show member pathways
12.83 CASP3 CCR4 CCR7 CD27 IL2
5
Show member pathways
12.36 CASP3 CD27 IFNG
6
Show member pathways
12.16 CASP3 IFNG IL2
7 11.58 CASP3 IFNG IL2
8 11.44 IFNG IL2
9 11.4 IFNG IL2
10
Show member pathways
11.37 IFNG IL2
11
Show member pathways
11.34 IFNG IL2
12 11.26 IFNG IL2
13 11.22 IFNG IL2
14
Show member pathways
11.21 CASP3 IFNG IL2
15 11.19 IFNG IL2
16 11.01 IFNG IL2
17 11 IFNG IL2 SELL
18 10.99 CCR7 IFNG IL2 SELL
19 10.94 IFNG IL2
20 10.9 IFNG IL2
21 10.85 IFNG IL2

GO Terms for Fixed Drug Eruption

Cellular components related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 CCR4 CCR7 CD27 SELL

Biological processes related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 chemokine-mediated signaling pathway GO:0070098 9.49 CCR4 CCR7
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.48 IFNG IL2
3 extrinsic apoptotic signaling pathway GO:0097191 9.46 CD27 IFNG
4 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 CASP3 IL2
5 response to antibiotic GO:0046677 9.4 CASP3 CCR4
6 positive regulation of interleukin-12 production GO:0032735 9.37 CCR7 IFNG
7 homeostasis of number of cells GO:0048872 9.32 CCR4 CCR7
8 positive regulation of T cell differentiation GO:0045582 9.26 CD27 IL2
9 regulation of regulatory T cell differentiation GO:0045589 9.16 IFNG IL2
10 positive regulation of cytosolic calcium ion concentration GO:0007204 9.13 CCR4 CCR7 IL2
11 immune response GO:0006955 8.92 CCR4 CCR7 IFNG IL2

Molecular functions related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine binding GO:0019956 9.32 CCR4 CCR7
2 C-C chemokine binding GO:0019957 9.26 CCR4 CCR7
3 C-C chemokine receptor activity GO:0016493 9.16 CCR4 CCR7
4 chemokine receptor activity GO:0004950 8.96 CCR4 CCR7
5 glycosphingolipid binding GO:0043208 8.62 IL2 SELL

Sources for Fixed Drug Eruption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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