MCID: FXD003
MIFTS: 35

Fixed Drug Eruption

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Fixed Drug Eruption

MalaCards integrated aliases for Fixed Drug Eruption:

Name: Fixed Drug Eruption 58 71

Characteristics:

Orphanet epidemiological data:

58
fixed drug eruption
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: All ages;

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

UMLS via Orphanet 72 C0877391
Orphanet 58 ORPHA293812
UMLS 71 C0221242

Summaries for Fixed Drug Eruption

MalaCards based summary : Fixed Drug Eruption is related to erythema multiforme and stevens-johnson syndrome/toxic epidermal necrolysis, and has symptoms including integumentary system signs and symptoms An important gene associated with Fixed Drug Eruption is CASP3 (Caspase 3), and among its related pathways/superpathways are ERK Signaling and PEDF Induced Signaling. Affiliated tissues include testes, skin and t cells, and related phenotypes are cellular and hematopoietic system

Related Diseases for Fixed Drug Eruption

Diseases related to Fixed Drug Eruption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 219)
# Related Disease Score Top Affiliating Genes
1 erythema multiforme 30.5 IL2 IFNG
2 stevens-johnson syndrome/toxic epidermal necrolysis 30.5 IL2 IFNG
3 exanthem 30.3 IL2 IFNG
4 dermatitis 29.9 IL2 IFNG CCR4
5 allergic hypersensitivity disease 29.8 SELL IL2 IFNG
6 cellulitis 29.4 IL2 IFNG
7 allergic conjunctivitis 29.3 IL2 IFNG
8 pelvic inflammatory disease 29.0 IL2 IFNG
9 cutaneous t cell lymphoma 29.0 IL2 IFNG CCR4
10 filariasis 28.9 IL2 IFNG CD27
11 thrombocytopenia 28.5 SELL IL2 IFNG CASP3
12 rheumatoid arthritis 28.3 SELL IL2 IFNG CCR7
13 immune deficiency disease 27.4 SELL IL2 IFNG CD27 CCR7 CCR4
14 dowling-degos disease 1 10.6
15 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.5
16 severe cutaneous adverse reaction 10.5
17 erythema multiforme major 10.5
18 urticaria 10.3
19 drug allergy 10.3
20 autoimmune progesterone dermatitis 10.3
21 diarrhea 10.2
22 skin disease 10.2
23 herpes simplex 10.2
24 common cold 10.2
25 candidiasis 10.2
26 contact dermatitis 10.2
27 vasculitis 10.2
28 renal cell carcinoma, nonpapillary 10.1
29 rhinitis 10.1
30 parapsoriasis 10.1
31 lichen planus 10.1
32 spotted fever 10.1 IFNG CASP3
33 nonspecific interstitial pneumonia 10.1 IFNG CCR4
34 panniculitis 10.0 IFNG CASP3
35 migraine with or without aura 1 10.0
36 cystic fibrosis 10.0
37 leprosy 3 10.0
38 prostatic hyperplasia, benign 10.0
39 allergic rhinitis 10.0
40 hepatitis c virus 10.0
41 prostatic hypertrophy 10.0
42 balanitis 10.0
43 paronychia 10.0
44 angioedema 10.0
45 impotence 10.0
46 hepatitis c 10.0
47 prostatic adenoma 10.0
48 pulmonary tuberculosis 10.0
49 purpura 10.0
50 vulvitis 10.0

Graphical network of the top 20 diseases related to Fixed Drug Eruption:



Diseases related to Fixed Drug Eruption

Symptoms & Phenotypes for Fixed Drug Eruption

UMLS symptoms related to Fixed Drug Eruption:


integumentary system signs and symptoms

MGI Mouse Phenotypes related to Fixed Drug Eruption:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.73 CASP3 CCR7 CD27 IFNG IL2 SELL
2 hematopoietic system MP:0005397 9.7 CASP3 CCR4 CCR7 CD27 IFNG IL2
3 immune system MP:0005387 9.5 CASP3 CCR4 CCR7 CD27 IFNG IL2
4 respiratory system MP:0005388 9.02 CASP3 CCR4 IFNG IL2 SELL

Drugs & Therapeutics for Fixed Drug Eruption

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Multicenter Registry of Patients With Severe Cutaneous Adverse Reactions Among Tertiary Medical Institutes in Thailand Recruiting NCT02574988

Search NIH Clinical Center for Fixed Drug Eruption

Genetic Tests for Fixed Drug Eruption

Anatomical Context for Fixed Drug Eruption

MalaCards organs/tissues related to Fixed Drug Eruption:

40
Testes, Skin, T Cells, Tongue, Neutrophil, Liver, Breast

Publications for Fixed Drug Eruption

Articles related to Fixed Drug Eruption:

(show top 50) (show all 899)
# Title Authors PMID Year
1
Fixed Drug Eruptions: An Update, Emphasizing the Potentially Lethal Generalized Bullous Fixed Drug Eruption. 61
32002848 2020
2
Fluconazole induced Fixed Drug Eruption confirmed by extemporaneous patch testing. 61
32542690 2020
3
Generalized bullous fixed drug eruption successfully treated with cyclosporine. 61
32356595 2020
4
Esomeprazole fixed drug eruption. 61
31967328 2020
5
A first case of fixed drug eruption due to Tamsulosin. 61
31541583 2020
6
Might your gin tonic make you sick? Fixed drug eruption likely due to quinine in gin tonic. 61
32383255 2020
7
Fixed drug eruption due to norfloxacin with cross-reactivity to ciprofloxacin: A case report. 61
32243605 2020
8
Desquamating Nonpigmenting Fixed Drug Eruption With Onycholysis due to Amoxicillin in a Child: Cross-reactivity Study. 61
31751290 2020
9
Fixed drug eruption to rupatadine with positive patch tests on non-lesional skin. 61
32342508 2020
10
Acetaminophen-induced generalized fixed drug eruption in a 5-year-old girl. 61
32285521 2020
11
Multilocular bullous fixed drug eruption elicited by paracetamol and migraine attacks, but not by paracetamol alone. 61
32314407 2020
12
Multiple widespread fixed drug eruption caused by rabeprazole. 61
32270780 2020
13
Generalized bullous fixed drug eruption: Trazodone as a new culprit. 61
31742734 2020
14
Fixed Drug Eruption on the Tongue Due to Naproxen. 61
32131994 2020
15
Loxoprofen-induced bullous fixed drug eruption. 61
32161698 2020
16
Hypersensitivity reactions to proton-pump inhibitors: Clinical presentation, diagnosis, and management. 61
32122452 2020
17
Bullous fixed drug eruption following Human Papilloma Virus (HPV) vaccination. 61
32181534 2020
18
When a Gin Tonic Can Mean Trouble: Fixed Drug Eruption Due to Quinine. 61
31879027 2020
19
Successful desensitization to metronidazole in a patient with generalized fixed drug eruption. 61
31369825 2020
20
Case of autoimmune progesterone dermatitis presenting as necrotic migratory erythema successfully controlled by danazol. 61
31829458 2020
21
Multiple Fixed Drug Eruption Mimicking Parapsoriasis en Plaque in a Patient with Hepatitis C Virus Infection. 61
32110206 2020
22
Tissue-resident memory T cells and their biological characteristics in the recurrence of inflammatory skin disorders. 61
31595056 2020
23
Evaluation of Subjects Experiencing Allergic Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Characteristics and Drugs Involved. 61
32425774 2020
24
Fixed drug eruption caused by allylisopropylacetylurea mimicking contact dermatitis of the face. 61
31400018 2020
25
Loss of tolerance 5 days after discontinuing sulphonamide introduced via desensitization in delayed reaction. 61
31778467 2020
26
Fixed Drug Eruption of the Tongue Due to Trimethoprim-Sulfamethoxazole. 61
31519543 2020
27
Ibuprofen-induced generalised bullous fixed drug eruption. 61
32001485 2020
28
Co-occurrence of Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE) and Pigmented Fixed Drug Eruption (FDE) in a Single Patient Due to Doxycycline: A Case Report. 61
32055511 2020
29
Vancomycin-induced linear IgA bullous dermatosis presenting as generalized fixed drug eruption. 61
31390070 2019
30
Fixed drug eruption caused by antibiotics contained in food? 61
30900776 2019
31
Autoimmune progesterone dermatitis presenting as fixed drug eruption. 61
31791987 2019
32
[Pitfall cryothermic dermatitis artefacta]. 61
31175372 2019
33
Tranexamic acid-induced fixed drug eruption confirmed by the drug lymphocyte transformation test. 61
31788254 2019
34
Celecoxib-induced bullous fixed drug eruption: An unusual presentation. 61
31376180 2019
35
Clinical features, culprit drugs, and allergology workup in 41 cases of fixed drug eruption. 61
31291002 2019
36
Bullous fixed drug eruption induced by etoricoxib, confirmed by patch testing, with tolerance to celecoxib. 61
31215658 2019
37
Multivitamins as a Culprit of Fixed Drug Eruption. 61
31896857 2019
38
A case of fixed drug eruption induced by doxycycline, mimicking a symmetrical drug-related intertriginous and flexural exanthema (SDRIFE). 61
31761151 2019
39
A fixed drug eruption caused by mycophenolate. 61
31687455 2019
40
[Fixed drug eruption induced by etoricoxib]. 61
30718025 2019
41
Bullous fixed drug eruption: A potential diagnostic pitfall: a study of 18 cases. 61
31006486 2019
42
Contrast-induced generalized bullous fixed drug eruption resembling Stevens-Johnson syndrome. 61
31656435 2019
43
Radiocontrast Media Hypersensitivity: Skin Testing Differentiates Allergy From Nonallergic Reactions and Identifies a Safe Alternative as Proven by Intravenous Provocation. 61
30980898 2019
44
Fixed Drug Eruption to Biologics and Role of Lesional Patch Testing. 61
31326380 2019
45
The Lymphocyte Transformation Test Is Useful in the Diagnosis of Fixed Drug Eruption Induced by Etoricoxib. 61
31478528 2019
46
Generalized Bullous Fixed Drug Eruption to Fluconazole; with Cross-Reactivity to Tinidazole. 61
31516152 2019
47
A pediatric case report of fixed drug eruption related to carmoisine colorant present in paracetamol syrup. 61
31571716 2019
48
Piroxicam-induced fixed drug eruption: Cross-reactivity with meloxicam. 61
30663057 2019
49
Bullous artificial dermatitis due to aerosol sprays masquerading as fixed drug eruption. 61
30565292 2019
50
Fixed drug eruption due To 2,3-dimercapto-1-propanesulfonic acid (DMPS) treatment for mercury poisoning: a rare adverse effect. 61
29912651 2019

Variations for Fixed Drug Eruption

Expression for Fixed Drug Eruption

Search GEO for disease gene expression data for Fixed Drug Eruption.

Pathways for Fixed Drug Eruption

Pathways related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

(show all 22)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 IL2 CD27 CCR7 CCR4 CASP3
2
Show member pathways
13.07 IL2 IFNG CD27 CCR7 CCR4 CASP3
3
Show member pathways
12.95 IL2 CD27 CCR7 CCR4 CASP3
4
Show member pathways
12.83 IL2 CD27 CCR7 CCR4 CASP3
5
Show member pathways
12.35 IFNG CD27 CASP3
6
Show member pathways
12.19 IL2 IFNG CASP3
7
Show member pathways
11.94 IL2 CCR7 CCR4
8 11.58 IL2 IFNG CASP3
9 11.42 IL2 IFNG
10
Show member pathways
11.4 IL2 IFNG
11
Show member pathways
11.37 IL2 IFNG
12 11.27 IL2 IFNG
13 11.24 IL2 IFNG
14 11.21 IL2 IFNG
15
Show member pathways
11.21 IL2 IFNG CASP3
16
Show member pathways
11.08 IL2 IFNG
17 11.03 IL2 IFNG
18 11 SELL IL2 IFNG
19 10.99 SELL IL2 IFNG CCR7
20 10.96 IL2 IFNG
21 10.92 IL2 IFNG
22 10.87 IL2 IFNG

GO Terms for Fixed Drug Eruption

Cellular components related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 SELL CD27 CCR7 CCR4

Biological processes related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extrinsic apoptotic signaling pathway GO:0097191 9.48 IFNG CD27
2 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.46 IL2 CASP3
3 response to antibiotic GO:0046677 9.43 CCR4 CASP3
4 positive regulation of interleukin-12 production GO:0032735 9.4 IFNG CCR7
5 homeostasis of number of cells GO:0048872 9.37 CCR7 CCR4
6 positive regulation of T cell differentiation GO:0045582 9.32 IL2 CD27
7 positive regulation of amyloid-beta formation GO:1902004 9.26 IFNG CASP3
8 regulation of regulatory T cell differentiation GO:0045589 9.16 IL2 IFNG
9 positive regulation of cytosolic calcium ion concentration GO:0007204 9.13 IL2 CCR7 CCR4
10 immune response GO:0006955 8.92 IL2 IFNG CCR7 CCR4

Molecular functions related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine binding GO:0019956 9.32 CCR7 CCR4
2 C-C chemokine binding GO:0019957 9.26 CCR7 CCR4
3 C-C chemokine receptor activity GO:0016493 9.16 CCR7 CCR4
4 chemokine receptor activity GO:0004950 8.96 CCR7 CCR4
5 glycosphingolipid binding GO:0043208 8.62 SELL IL2

Sources for Fixed Drug Eruption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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