MCID: FXD003
MIFTS: 36

Fixed Drug Eruption

Categories: Rare diseases, Skin diseases

Aliases & Classifications for Fixed Drug Eruption

MalaCards integrated aliases for Fixed Drug Eruption:

Name: Fixed Drug Eruption 59 72

Characteristics:

Orphanet epidemiological data:

59
fixed drug eruption
Inheritance: Not applicable; Prevalence: <1/1000000 (Worldwide); Age of onset: All ages;

Classifications:

Orphanet: 59  
Rare skin diseases


External Ids:

UMLS via Orphanet 73 C0877391
Orphanet 59 ORPHA293812
UMLS 72 C0221242

Summaries for Fixed Drug Eruption

MalaCards based summary : Fixed Drug Eruption is related to erythema multiforme and stevens-johnson syndrome/toxic epidermal necrolysis, and has symptoms including integumentary system signs and symptoms An important gene associated with Fixed Drug Eruption is CASP3 (Caspase 3), and among its related pathways/superpathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Affiliated tissues include testes, skin and t cells, and related phenotypes are cellular and hematopoietic system

Related Diseases for Fixed Drug Eruption

Diseases related to Fixed Drug Eruption via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 172)
# Related Disease Score Top Affiliating Genes
1 erythema multiforme 30.9 IL2 IFNG
2 stevens-johnson syndrome/toxic epidermal necrolysis 30.9 IL2 IFNG
3 leprosy 3 30.1 IL2 IFNG
4 conjunctivitis 29.9 IL2 IFNG
5 filariasis 29.7 IL2 IFNG
6 cutaneous t cell lymphoma 29.2 IL2 IFNG CCR4
7 dowling-degos disease 1 10.6
8 exanthem 10.5
9 x-linked intellectual disability-macrocephaly-macroorchidism syndrome 10.5
10 severe cutaneous adverse reaction 10.5
11 erythema multiforme major 10.5
12 allergic hypersensitivity disease 10.5
13 dermatitis 10.4
14 pars planitis 10.4 CD27 CCR7
15 urticaria 10.3
16 drug allergy 10.3
17 lower lip cancer 10.2 IL2 CASP3
18 diarrhea 10.2
19 skin disease 10.2
20 herpes simplex 10.2
21 autoimmune progesterone dermatitis 10.2
22 common cold 10.2
23 candidiasis 10.2
24 contact dermatitis 10.2
25 cellulitis 10.2
26 vasculitis 10.2
27 renal cell carcinoma, nonpapillary 10.1
28 rhinitis 10.1
29 influenza 10.1
30 hard palate cancer 10.1
31 variola major 10.1 IL2 IFNG
32 berylliosis 10.1 IL2 IFNG
33 atopic keratoconjunctivitis 10.1 IL2 IFNG
34 keratoconjunctivitis 10.1 IL2 IFNG
35 clonorchiasis 10.1 IL2 IFNG
36 crohn's colitis 10.1 IL2 IFNG
37 chronic active epstein-barr virus infection 10.1 IL2 IFNG
38 intermediate uveitis 10.1 IL2 IFNG
39 posterior uveitis 10.1 IL2 IFNG
40 coccidiosis 10.1 IL2 IFNG
41 hematopoietic stem cell transplantation 10.1 IL2 IFNG
42 vernal conjunctivitis 10.0 IL2 IFNG
43 hypersensitivity reaction type iv disease 10.0 IL2 IFNG
44 autoimmune disease of endocrine system 10.0 IL2 IFNG
45 acute graft versus host disease 10.0 IL2 IFNG
46 leukocyte disease 10.0 IL2 CASP3
47 cystic fibrosis 10.0
48 pulmonary alveolar microlithiasis 10.0
49 allergic rhinitis 10.0
50 balanitis 10.0

Graphical network of the top 20 diseases related to Fixed Drug Eruption:



Diseases related to Fixed Drug Eruption

Symptoms & Phenotypes for Fixed Drug Eruption

UMLS symptoms related to Fixed Drug Eruption:


integumentary system signs and symptoms

MGI Mouse Phenotypes related to Fixed Drug Eruption:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.8 CASP3 CCR7 CD27 IFNG IL2 SELL
2 hematopoietic system MP:0005397 9.7 CASP3 CCR4 CCR7 CD27 IFNG IL2
3 endocrine/exocrine gland MP:0005379 9.65 CASP3 CCR7 IFNG IL2 SELL
4 immune system MP:0005387 9.5 CASP3 CCR4 CCR7 CD27 IFNG IL2
5 respiratory system MP:0005388 9.02 CASP3 CCR4 IFNG IL2 SELL

Drugs & Therapeutics for Fixed Drug Eruption

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 The Multicenter Registry of Patients With Severe Cutaneous Adverse Reactions Among Tertiary Medical Institutes in Thailand Recruiting NCT02574988

Search NIH Clinical Center for Fixed Drug Eruption

Genetic Tests for Fixed Drug Eruption

Anatomical Context for Fixed Drug Eruption

MalaCards organs/tissues related to Fixed Drug Eruption:

41
Testes, Skin, T Cells, Tongue, Neutrophil, Liver, Breast

Publications for Fixed Drug Eruption

Articles related to Fixed Drug Eruption:

(show top 50) (show all 862)
# Title Authors PMID Year
1
Fixed drug eruption caused by allylisopropylacetylurea mimicking contact dermatitis of the face. 38
31400018 2019
2
Celecoxib-induced bullous fixed drug eruption: An unusual presentation. 38
31376180 2019
3
Vancomycin-induced linear IgA bullous dermatosis presenting as generalized fixed drug eruption. 38
31390070 2019
4
Clinical features, culprit drugs, and allergology workup in 41 cases of fixed drug eruption. 38
31291002 2019
5
Successful desensitization to metronidazole in a patient with generalized fixed drug eruption. 38
31369825 2019
6
Fixed Drug Eruption to Biologics and Role of Lesional Patch Testing. 38
31326380 2019
7
Piroxicam-induced fixed drug eruption: Cross-reactivity with meloxicam. 38
30663057 2019
8
Bullous artificial dermatitis due to aerosol sprays masquerading as fixed drug eruption. 38
30565292 2019
9
[Pitfall cryothermic dermatitis artefacta]. 38
31175372 2019
10
Fixed drug eruption due To 2,3-dimercapto-1-propanesulfonic acid (DMPS) treatment for mercury poisoning: a rare adverse effect. 38
29912651 2019
11
Fixed drug eruption due to itraconazole: a rare occurence. 38
31085618 2019
12
S-Carboxymethyl-L-cysteine-induced Fixed Drug Eruption. 38
30938829 2019
13
Bullous fixed drug eruption induced by etoricoxib, confirmed by patch testing, with tolerance to celecoxib. 38
31215658 2019
14
Bullous Fixed Drug Eruption Caused by Etoricoxib Confirmed by Patch Testing. 38
30777670 2019
15
Fixed drug eruption on the tongue associated with piroxicam: report of two cases and literature review. 38
30853413 2019
16
Non-Pigmented Fixed Drug Eruption Caused by Ibuprofen. 38
31149592 2019
17
Lentigines within fixed drug eruption: reply to 'Multiple lentigines arising on resolving psoriatic plaques after treatment with apremilast'. 38
30575106 2019
18
Radiocontrast Media Hypersensitivity: Skin Testing Differentiates Allergy From Nonallergic Reactions and Identifies a Safe Alternative as Proven by Intravenous Provocation. 38
30980898 2019
19
Generalized bullous fixed drug eruption caused by ibuprofen. 38
30430598 2019
20
Can a single drug administration elicit two different immunological pathways at the same time? Fixed drug eruption after anaphylaxis. 38
29192468 2019
21
Fixed drug eruption caused by antibiotics contained in food? 38
30900776 2019
22
Fixed drug eruption caused by fulvestrant confirmed by skin tests: First case. 38
30461027 2019
23
Fixed drug eruption caused by fluconazole-An underdiagnosed but recurrent problem. 38
30417394 2019
24
Bullous fixed drug eruption: A potential diagnostic pitfall: a study of 18 cases. 38
31006486 2019
25
A case of entecavir-associated bullous fixed drug eruption and a review of literature. 38
30459136 2019
26
Herpes simplex-like Fixed Drug Eruption Induced by Fluconazole Without Cross-reactivity to Itraconazole. 38
30829805 2019
27
Neutrophilic fixed drug eruption: a mimic of neutrophilic dermatoses. 38
30198122 2019
28
[Fixed drug eruption induced by etoricoxib]. 38
30718025 2019
29
Generalized fixed drug eruption mimicking CD8+ cutaneous T-cell lymphoma in HIV. 38
30328131 2019
30
Fixed Drug Eruption Due to Chlorhexidine Mouthwash Confirmed by Lesional Patch Testing. 38
30205946 2019
31
A case report of fixed drug eruption caused by several drugs because of cross-reactivity and co-sensitization. 38
30246872 2019
32
Clinical Profile and Comparison of Causality Assessment Tools in Cutaneous Adverse Drug Reactions. 38
30775295 2019
33
Norfloxacin Induced Recurrent Fixed Drug Eruption in a self Treated Adult Female Patient - A Case Report. 38
30084337 2019
34
Fixed drug eruption caused by drinking alcohol. 38
29920750 2019
35
ISMP Adverse Drug Reactions: Lithium-Induced Cardiomyopathy Fixed Drug Eruption Due to Cetirizine, Levocetirizine, and Hydroxyzine Nivolumab-Induced Myasthenia Gravis Nivolumab-Induced Cholangitic Liver Disease Torsade de Pointes Caused by Psychiatric Polypharmacy Trichotillomania Associated With Aripiprazole. 38
30559522 2018
36
Autoimmune progesterone dermatitis manifesting as generalized fixed drug eruption. 38
30484533 2018
37
Paracetamol-induced fixed drug eruption presenting as eyelid skin necrosis. 38
30355885 2018
38
Mucosal fixed drug eruption due to mefenamic acid: Report of a case and a review. 38
29525693 2018
39
Generalized bullous fixed-drug eruption secondary to the influenza vaccine. 38
30364778 2018
40
Ivermectin-induced fixed drug eruption in an elderly Cameroonian: a case report. 38
30201032 2018
41
Cyclosporine in Generalized Bullous-Fixed Drug Eruption. 38
30210171 2018
42
Occupational fixed drug eruption with ipe wood. 38
29766517 2018
43
Fixed Drug Eruption Related to Cefixime in an Adolescent Case. 38
29339130 2018
44
Comments on Ben Mansour et al: Additional cases of multifocal fixed drug eruption to ceftazidime. 38
29537668 2018
45
A Probable Case of Mucosal Fixed Drug Eruption Following Treatment with Silodosin. 38
30607288 2018
46
Pheniramine maleate: an apparently safe drug causing bullous fixed drug eruption. 38
30142724 2018
47
Mesalazine-induced bullous fixed drug eruption. 38
29446099 2018
48
Fixed-drug Eruptions: What can we Learn from a Case Series? 38
30078879 2018
49
Fixed drug eruption to nimesulide: an exuberant presentation confirmed by patch testing. 38
29924254 2018
50
Local desensitization and progression of multiple fixed drug eruption. 38
30105994 2018

Variations for Fixed Drug Eruption

Expression for Fixed Drug Eruption

Search GEO for disease gene expression data for Fixed Drug Eruption.

Pathways for Fixed Drug Eruption

Pathways related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.07 IL2 IFNG CD27 CCR7 CCR4 CASP3
2
Show member pathways
13.01 IL2 IFNG CD27 CASP3
3
Show member pathways
12.95 IL2 CD27 CCR7 CCR4 CASP3
4
Show member pathways
12.83 IL2 CD27 CCR7 CCR4 CASP3
5
Show member pathways
12.36 IFNG CD27 CASP3
6
Show member pathways
12.16 IL2 IFNG CASP3
7 11.58 IL2 IFNG CASP3
8 11.44 IL2 IFNG
9 11.4 IL2 IFNG
10
Show member pathways
11.37 IL2 IFNG
11
Show member pathways
11.34 IL2 IFNG
12 11.26 IL2 IFNG
13 11.22 IL2 IFNG
14
Show member pathways
11.21 IL2 IFNG CASP3
15 11.19 IL2 IFNG
16 11.01 IL2 IFNG
17 11 SELL IL2 IFNG
18 10.99 SELL IL2 IFNG CCR7
19 10.94 IL2 IFNG
20 10.9 IL2 IFNG
21 10.85 IL2 IFNG

GO Terms for Fixed Drug Eruption

Cellular components related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.92 SELL CD27 CCR7 CCR4

Biological processes related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 chemokine-mediated signaling pathway GO:0070098 9.49 CCR7 CCR4
2 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.48 IL2 IFNG
3 extrinsic apoptotic signaling pathway GO:0097191 9.46 IFNG CD27
4 extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 9.43 IL2 CASP3
5 response to antibiotic GO:0046677 9.4 CCR4 CASP3
6 positive regulation of interleukin-12 production GO:0032735 9.37 IFNG CCR7
7 homeostasis of number of cells GO:0048872 9.32 CCR7 CCR4
8 positive regulation of T cell differentiation GO:0045582 9.26 IL2 CD27
9 regulation of regulatory T cell differentiation GO:0045589 9.16 IL2 IFNG
10 positive regulation of cytosolic calcium ion concentration GO:0007204 9.13 IL2 CCR7 CCR4
11 immune response GO:0006955 8.92 IL2 IFNG CCR7 CCR4

Molecular functions related to Fixed Drug Eruption according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine binding GO:0019956 9.32 CCR7 CCR4
2 C-C chemokine binding GO:0019957 9.26 CCR7 CCR4
3 C-C chemokine receptor activity GO:0016493 9.16 CCR7 CCR4
4 chemokine receptor activity GO:0004950 8.96 CCR7 CCR4
5 glycosphingolipid binding GO:0043208 8.62 SELL IL2

Sources for Fixed Drug Eruption

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
Content
Loading form....