MCID: FLP002
MIFTS: 14

Floppy Infant Syndrome

Categories: Muscle diseases, Neuronal diseases

Aliases & Classifications for Floppy Infant Syndrome

MalaCards integrated aliases for Floppy Infant Syndrome:

Name: Floppy Infant Syndrome 54

Classifications:



Summaries for Floppy Infant Syndrome

NINDS : 54 Hypotonia is a medical term used to describe decreased muscle tone.  Normally, even when relaxed, muscles have a very small amount of contraction that gives them a springy feel and provides some resistance to passive movement.  It is not the same as muscle weakness, although the two conditions can co-exist.  Muscle tone is regulated by signals that travel from the brain to the nerves and tell the muscles to contract.  Hypotonia can happen from damage to the brain, spinal cord, nerves, or muscles.  The damage can be the result of trauma, environmental factors, or genetic, muscle, or central nervous system disorders.  For example, it can be seen in Down syndrome, muscular dystrophy, cerebral palsy, Prader-Willi syndrome, myotonic dystrophy, and Tay-Sachs disease.  Sometimes it may not be possible to find what causes the hypotonia.  Infants with hypotonia have a floppy quality or “rag doll” appearance because their arms and legs hang by their sides and they have little or no head control.  Other symptoms of hypotonia include problems with mobility and posture, breathing and speech difficulties, ligament and joint laxity, and poor reflexes.  Hypotonia does not affect intellect.  The opposite of hypotonia is hypertonia.

MalaCards based summary : Floppy Infant Syndrome is related to hypotonia and spinal muscular atrophy. Affiliated tissues include brain, spinal cord and skeletal muscle.

Wikipedia : 75 Hypotonia, commonly known as floppy baby syndrome, is a state of low muscle tone (the amount of tension... more...

Related Diseases for Floppy Infant Syndrome

Diseases related to Floppy Infant Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 hypotonia 10.2
2 spinal muscular atrophy 10.1
3 muscular atrophy 10.1
4 central core disease of muscle 9.9
5 myopathy, congenital 9.9
6 muscular dystrophy, congenital, lmna-related 9.9
7 foodborne botulism 9.9
8 infant botulism 9.9
9 autosomal recessive disease 9.9
10 withdrawal disorder 9.9
11 organic acidemia 9.9
12 pontocerebellar hypoplasia 9.9
13 congenital fiber-type disproportion 9.9
14 centronuclear myopathy 9.9
15 cerebral palsy 9.9
16 glycogen storage disease 9.9
17 nemaline myopathy 9.9
18 myopathy 9.9
19 neuromuscular disease 9.9
20 muscular dystrophy 9.9
21 myotonic dystrophy 9.9
22 myotonia atrophica 9.9
23 muscular glycogenosis 9.9
24 muscular lipidosis 9.9
25 metabolic myopathy 9.9

Graphical network of the top 20 diseases related to Floppy Infant Syndrome:



Diseases related to Floppy Infant Syndrome

Symptoms & Phenotypes for Floppy Infant Syndrome

Drugs & Therapeutics for Floppy Infant Syndrome

Search Clinical Trials , NIH Clinical Center for Floppy Infant Syndrome

Genetic Tests for Floppy Infant Syndrome

Anatomical Context for Floppy Infant Syndrome

MalaCards organs/tissues related to Floppy Infant Syndrome:

41
Brain, Spinal Cord, Skeletal Muscle, Breast

Publications for Floppy Infant Syndrome

Articles related to Floppy Infant Syndrome:

(show top 50) (show all 53)
# Title Authors PMID Year
1
Single nucleotide polymorphism array analysis uncovers a large, novel duplication in Xq13.1 in a floppy infant syndrome patient. 38
30217625 2019
2
[Identification of a novel duplication of Xq13.1 in a case with floppy infant syndrome with SNP-array]. 38
30298503 2018
3
A review of the safety of clozapine during pregnancy and lactation. 38
27704220 2017
4
Congenital muscular dystrophy with inflammation: Diagnostic considerations. 38
27570388 2016
5
[Pontocerebellar hypoplasia is a rare cause of floppy infant syndrome]. 38
26418712 2015
6
Infantile form of muscle phosphofructokinase deficiency in a premature neonate. 38
26108272 2015
7
[The role of lactate acidosis in the development and treatment of various neurologic syndromes in children and adolescents]. 38
25802453 2015
8
Clinical and skeletal muscle biopsy characteristics of 25 patients with floppy infant syndrome. 38
23743156 2013
9
Side effects of treatment with benzodiazepines. 38
20305598 2010
10
Ephedrine therapy in eight patients with congenital myasthenic syndrome due to DOK7 mutations. 38
19837590 2009
11
Omigapil ameliorates the pathology of muscle dystrophy caused by laminin-alpha2 deficiency. 38
19759319 2009
12
[Neonatal Volkmann's syndrome]. 38
19917430 2009
13
Neuromuscular junctional disorders. 38
18716738 2008
14
Floppy infant caused by MTM1 mutation: a first genetically-confirmed X-linked myotubular myopathy patient in Thailand. 38
16583589 2006
15
Infantile hepatocerebral syndromes associated with mutations in the mitochondrial DNA polymerase-gammaA. 38
15689359 2005
16
Neuromuscular rehabilitation and electrodiagnosis. 4. Pediatric issues. 38
15761797 2005
17
Floppy infant syndrome. 38
19078754 2004
18
The floppy infant: contribution of genetic and metabolic disorders. 38
13129589 2003
19
[Clozapine and pregnancy]. 38
14567163 2003
20
[Placental passage of anesthetics and adjuvants]. 38
12125314 2002
21
Pregnancy and the Ehlers-Danlos syndrome: a retrospective study in a Dutch population. 38
11952457 2002
22
["Floppy infant" syndrome in twins secondary to the use of benzodiazepines during pregnancy]. 38
10528322 1999
23
Neuropathy in two cobalamin-deficient breast-fed infants of vegetarian mothers. 38
10024138 1999
24
[Muscular dystrophies due to alterations at extracellular space level: congenital muscular dystrophy caused by merosin deficiency]. 38
10101782 1999
25
Infantile muscle phosphorylase-b-kinase deficiency. A case report. 38
9553951 1998
26
[Psychopharmacotherapy during pregnancy and lactation. 1: Pregnancy]. 38
9522327 1998
27
Neuromuscular disorders in infancy and childhood. 38
29512574 1997
28
[Diagnostic problems of congenital muscular dystrophies in children]. 38
7624173 1995
29
The effects of benzodiazepine use during pregnancy and lactation. 38
7881198 1994
30
Electromyography and biopsy correlation with suggested protocol for evaluation of the floppy infant. 38
8170489 1994
31
[Severe and mild forms of nemaline myopathy: a report of three cases]. 38
8166407 1993
32
[Neurological symptoms in newborn infants due to the administration of psychopharmacologic agents during pregnancy]. 38
8105393 1993
33
[Botulism in infancy. A rare cause of floppy infant syndrome]. 38
8446115 1993
34
Dystrophin deficiency in a case of congenital myopathy. 38
1552307 1992
35
Ketamine monoanaesthesia for diagnostic muscle biopsy in neuromuscular disorders in infancy and childhood: floppy infant syndrome. 38
2340618 1990
36
The floppy infant syndrome. 38
2595188 1989
37
Congenital myopathies with "diagnostic" pathological features. 38
3323392 1987
38
Obstetric analgesia: pharmacokinetics and its relation to neonatal behavioral and adaptive functions. 38
6142732 1984
39
Early infant death in nemaline (rod) myopathy. 38
6846734 1983
40
Use of benzodiazepines during pregnancy, labour and lactation, with particular reference to pharmacokinetic considerations. 38
6124415 1982
41
[Late myopathy with mitochondrial changes in the muscle]. 38
6455035 1981
42
A clinico-pathological study of the floppy infant syndrome. 38
659092 1978
43
Floppy-infant syndrome: Is oxazepam the answer? 38
73027 1977
44
Floppy-infant syndrome and maternal diazepam and/or nitrazepam. 38
72227 1977
45
"Floppy infant syndrome" and maternal diazepam. 38
71430 1977
46
"Floppy infant syndrome" and maternal diazepam. 38
69847 1977
47
Organic aciduria. Treatable cause of floppy infant syndrome. 38
962376 1976
48
Prenatal diagnosis and genetic counseling. 38
1274337 1976
49
An especially mild myopathic form of glycogenosis type II. Problems of clinical and light microscopic diagnosis. 38
132627 1976
50
[The floppy infant syndrome]. 38
4569223 1973

Variations for Floppy Infant Syndrome

Expression for Floppy Infant Syndrome

Search GEO for disease gene expression data for Floppy Infant Syndrome.

Pathways for Floppy Infant Syndrome

GO Terms for Floppy Infant Syndrome

Sources for Floppy Infant Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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