Focal Chorioretinitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Focal Chorioretinitis

MalaCards integrated aliases for Focal Chorioretinitis:

Name: Focal Chorioretinitis ¹² ¹⁵ ⁷³

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the eye and adnexa

Disorders of choroid and retina

Chorioretinal inflammation

Focal chorioretinal inflammation

External Ids:

Disease Ontology ¹² DOID:1979

ICD10 ³³ H30.0 H30.00

ICD9CM ³⁵ 363.0 363.00

SNOMED-CT ⁶⁸ 15847003 458003

UMLS ⁷³ C0154870

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Summaries for Focal Chorioretinitis

MalaCards based summary : Focal Chorioretinitis is related to peripheral focal chorioretinitis and chorioretinitis. An important gene associated with Focal Chorioretinitis is CNGB3 (Cyclic Nucleotide Gated Channel Beta 3), and among its related pathways/superpathways are Phototransduction and Visual Cycle in Retinal Rods. Affiliated tissues include eye, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

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Related Diseases for Focal Chorioretinitis

Diseases related to Focal Chorioretinitis via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	peripheral focal chorioretinitis	12.2
2	chorioretinitis	10.2
3	syphilis	9.8
4	iridocyclitis	9.8
5	meningitis	9.8
6	retinal disease	9.8	CNGB3 SAG
7	congenital stationary night blindness	9.7	CNGB3 SAG
8	ewing sarcoma	9.6	CNGB3 SAG

Graphical network of the top 20 diseases related to Focal Chorioretinitis:

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Symptoms & Phenotypes for Focal Chorioretinitis

GenomeRNAi Phenotypes related to Focal Chorioretinitis according to GeneCards Suite gene sharing:

²⁶ (show all 20)

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased shRNA abundance (Z-score < -2)	GR00366-A-154	9.5	DDX41
2	Decreased shRNA abundance (Z-score < -2)	GR00366-A-20	9.5	DDX41
3	Decreased shRNA abundance (Z-score < -2)	GR00366-A-213	9.5	DDX41 SAG
4	Decreased shRNA abundance (Z-score < -2)	GR00366-A-55	9.5	SAG
5	Decreased shRNA abundance (Z-score < -2)	GR00366-A-87	9.5	SAG
6	Decreased shRNA abundance (Z-score < -2)	GR00366-A-89	9.5	SAG
7	Increased shRNA abundance (Z-score > 2)	GR00366-A-105	9.5	SAG
8	Increased shRNA abundance (Z-score > 2)	GR00366-A-107	9.5	SAG
9	Increased shRNA abundance (Z-score > 2)	GR00366-A-126	9.5	CNGB3
10	Increased shRNA abundance (Z-score > 2)	GR00366-A-16	9.5	CNGB3
11	Increased shRNA abundance (Z-score > 2)	GR00366-A-164	9.5	SAG
12	Increased shRNA abundance (Z-score > 2)	GR00366-A-168	9.5	CNGB3
13	Increased shRNA abundance (Z-score > 2)	GR00366-A-194	9.5	SAG
14	Increased shRNA abundance (Z-score > 2)	GR00366-A-195	9.5	SAG
15	Increased shRNA abundance (Z-score > 2)	GR00366-A-42	9.5	SAG
16	Increased shRNA abundance (Z-score > 2)	GR00366-A-43	9.5	CNGB3 SAG
17	Increased shRNA abundance (Z-score > 2)	GR00366-A-73	9.5	CNGB3
18	Increased shRNA abundance (Z-score > 2)	GR00366-A-9	9.5	CNGB3
19	Increased shRNA abundance (Z-score > 2)	GR00366-A-97	9.5	SAG
20	Increased shRNA abundance (Z-score > 2)	GR00366-A-99	9.5	SAG

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Drugs & Therapeutics for Focal Chorioretinitis

Search Clinical Trials , NIH Clinical Center for Focal Chorioretinitis

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Genetic Tests for Focal Chorioretinitis

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Anatomical Context for Focal Chorioretinitis

MalaCards organs/tissues related to Focal Chorioretinitis:

⁴¹

Eye

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Publications for Focal Chorioretinitis

Articles related to Focal Chorioretinitis:

#	Title	Authors	Year
1	Bilateral papillitis and unilateral focal chorioretinitis as the presenting features of syphilis. ( 26069511 )	Benson C.E....Do D.V.	2015
2	FOCAL CHORIORETINITIS IN THAILAND. ( 23928678 )		2013
3	Meningococcal group B meningitis associated with a focal chorioretinitis. ( 15731773 )	Rathod D....Heath J.D.	2005
4	Focal chorioretinitis and iridocyclitis associated with scleroderma. ( 942839 )		1976
5	FOCAL CHORIORETINITIS PRODUCED BY ULTRASOUND. ( 14238877 )		1964
6	THE PRODUCTION OF FOCAL CHORIORETINITIS BY ULTRASOUND. A PRELIMINARY REPORT. ( 14233719 )		1964

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Genes for Focal Chorioretinitis

Genes related to Focal Chorioretinitis (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CNGB3	Cyclic Nucleotide Gated Channel Beta 3	Protein Coding	16.45	DISEASES inferred ¹⁵
2	SAG	S-Antigen Visual Arrestin	Protein Coding	15.56	DISEASES inferred ¹⁵
3	DDX41	DEAD-Box Helicase 41	Protein Coding	14.66	DISEASES inferred ¹⁵

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Variations for Focal Chorioretinitis

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Expression for Focal Chorioretinitis

Search GEO for disease gene expression data for Focal Chorioretinitis.

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Pathways for Focal Chorioretinitis

Pathways related to Focal Chorioretinitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Phototransduction ³⁷ Show member pathways Activation of the phototransduction cascade ⁶⁶ Inactivation, recovery and regulation of the phototransduction cascade ⁶⁶ The phototransduction cascade ⁶⁶ Visual signal transduction- Cones ¹ Visual signal transduction- Rods ¹	11.35	CNGB3 SAG
2	Visual Cycle in Retinal Rods ⁶⁴	10.6	CNGB3 SAG
3	Development_Thrombopoetin signaling via JAK-STAT pathway ²²	10.32	CNGB3 SAG

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GO Terms for Focal Chorioretinitis

Cellular components related to Focal Chorioretinitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	photoreceptor outer segment	GO:0001750	8.62	CNGB3 SAG

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