MCID: FCL010
MIFTS: 36

Focal Epithelial Hyperplasia

Categories: Infectious diseases

Aliases & Classifications for Focal Epithelial Hyperplasia

MalaCards integrated aliases for Focal Epithelial Hyperplasia:

Name: Focal Epithelial Hyperplasia 12 55 44 15 73
Multifocal Epithelial Hyperplasia 12
Heck's Disease 12
Heck Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5362
MeSH 44 D017573
NCIt 50 C97083
SNOMED-CT 68 36949004 6121001
UMLS 73 C0206067

Summaries for Focal Epithelial Hyperplasia

Disease Ontology : 12 A viral infectious disease that results in infection located in mouth, has material basis in human papillomavirus (types 13 or 32), has symptom papules or nodules in the oral cavity.

MalaCards based summary : Focal Epithelial Hyperplasia, also known as multifocal epithelial hyperplasia, is related to focal epithelial hyperplasia, oral and focal epithelial hyperplasia of the oral mucosa, and has symptoms including papules or nodules in the oral cavity and oral manifestations. An important gene associated with Focal Epithelial Hyperplasia is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Actin Nucleation by ARP-WASP Complex and TCR Signaling (Qiagen). Affiliated tissues include mouth and tongue.

Wikipedia : 76 Heck\'s disease (also known as focal or multifocal epithelial hyperplasia) is an asymptomatic, benign... more...

Related Diseases for Focal Epithelial Hyperplasia

Diseases related to Focal Epithelial Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 focal epithelial hyperplasia, oral 12.4
2 focal epithelial hyperplasia of the oral mucosa 12.3
3 idiopathic inflammatory myopathy 10.3 HLA-DQA1 HLA-DRB1
4 eosinophilia-myalgia syndrome 10.3 HLA-DQA1 HLA-DRB1
5 sympathetic ophthalmia 10.2 HLA-DQA1 HLA-DRB1
6 limbic encephalitis with lgi1 antibodies 10.2 HLA-DQB1 HLA-DRB1
7 metal allergy 10.2 HLA-DQB1 HLA-DRB1
8 hypersomnia 10.2 HLA-DQB1 HLA-DRB1
9 lichen planopilaris 10.2 HLA-DQB1 HLA-DRB1
10 type ii mixed cryoglobulinemia 10.2 HLA-DQB1 HLA-DRB1
11 beryllium disease 10.2 HLA-DQB1 HLA-DRB1
12 rheumatic heart disease 10.2 HLA-DQA1 HLA-DRB1
13 autoimmune pancreatitis 10.2 HLA-DQB1 HLA-DRB1
14 chronic beryllium disease 10.2 HLA-DQB1 HLA-DRB1
15 pityriasis rosea 10.1 HLA-DQB1 HLA-DRB1
16 lichen sclerosus 10.1 HLA-DQB1 HLA-DRB1
17 whipple disease 10.1 HLA-DQB1 HLA-DRB1
18 acute disseminated encephalomyelitis 10.1 HLA-DQB1 HLA-DRB1
19 pediatric multiple sclerosis 10.1 HLA-DQB1 HLA-DRB1
20 achalasia, familial esophageal 10.1 HLA-DQA1 HLA-DQB1
21 osteonecrosis of the jaw 10.1 HLA-DQB1 HLA-DRB1
22 juvenile rheumatoid arthritis 10.1 HLA-DQA1 HLA-DRB1
23 peanut allergy 10.1 HLA-DQB1 HLA-DRB1
24 panuveitis 10.1 HLA-DQB1 HLA-DRB1
25 geographic tongue 10.1 HLA-DQB1 HLA-DRB1
26 severe hemophilia a 10.1 HLA-DQB1 HLA-DRB1
27 congenital toxoplasmosis 10.1 HLA-DQA1 HLA-DQB1
28 ocular cicatricial pemphigoid 10.0 HLA-DQB1 HLA-DRB1
29 paraneoplastic pemphigus 10.0 HLA-DQB1 HLA-DRB1
30 rubella 10.0 HLA-DQB1 HLA-DRB1
31 endometritis 10.0 HLA-DQA1 HLA-DQB1
32 mucositis 10.0
33 papilloma 10.0
34 graft-versus-host disease 10.0 HLA-DQB1 HLA-DRB1
35 dermatitis herpetiformis 10.0 HLA-DQA1 HLA-DQB1
36 autoimmune hepatitis 9.9 HLA-DQB1 HLA-DRB1
37 toxoplasmosis 9.9 HLA-DQA1 HLA-DQB1
38 bullous pemphigoid 9.9 HLA-DQB1 HLA-DRB1
39 leukocyte adhesion deficiency, type i 9.7
40 keratoacanthoma 9.7
41 molluscum contagiosum 9.7
42 celiac disease 1 9.7 HLA-DQA1 HLA-DQB1
43 connective tissue disease 9.7 HLA-DQA1 HLA-DRB1
44 recurrent respiratory papillomatosis 9.6 HLA-DQA1 HLA-DQB1 HLA-DRB1
45 idiopathic bronchiectasis 9.6 HLA-DQA1 HLA-DQB1 HLA-DRB1
46 oligoarticular juvenile idiopathic arthritis 9.6 HLA-DQA1 HLA-DQB1 HLA-DRB1
47 vogt-koyanagi-harada disease 9.6 HLA-DQA1 HLA-DQB1 HLA-DRB1
48 leishmaniasis 9.6 HLA-DQA1 HLA-DQB1 HLA-DRB1
49 narcolepsy 9.5 HLA-DQA1 HLA-DQB1 HLA-DRB1
50 diabetes mellitus, insulin-dependent 9.5 HLA-DQA1 HLA-DQB1 HLA-DRB1

Graphical network of the top 20 diseases related to Focal Epithelial Hyperplasia:



Diseases related to Focal Epithelial Hyperplasia

Symptoms & Phenotypes for Focal Epithelial Hyperplasia

Symptoms:

12
  • papules or nodules in the oral cavity

UMLS symptoms related to Focal Epithelial Hyperplasia:


oral manifestations

Drugs & Therapeutics for Focal Epithelial Hyperplasia

Search Clinical Trials , NIH Clinical Center for Focal Epithelial Hyperplasia

Cochrane evidence based reviews: focal epithelial hyperplasia

Genetic Tests for Focal Epithelial Hyperplasia

Anatomical Context for Focal Epithelial Hyperplasia

The Foundational Model of Anatomy Ontology organs/tissues related to Focal Epithelial Hyperplasia:

19
Mouth

MalaCards organs/tissues related to Focal Epithelial Hyperplasia:

41
Tongue

Publications for Focal Epithelial Hyperplasia

Articles related to Focal Epithelial Hyperplasia:

(show top 50) (show all 153)
# Title Authors Year
1
Focal Epithelial Hyperplasia (Heck's Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review. ( 26985258 )
2016
2
Focal Epithelial Hyperplasia in Adult Patients With HIV Infection: Clearance With Topical Imiquimod. ( 27871359 )
2016
3
Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13. ( 27882674 )
2016
4
Pediatric Dermatology Photoquiz: Multiple Papules on the Mucosal Surfaces of a 17-Year-Old Boy. Focal epithelial hyperplasia (Heck's disease). ( 26758095 )
2016
5
Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13. ( 27072123 )
2016
6
Focal epithelial hyperplasia by human papillomavirus (HPV)-32 misdiagnosed as HPV-16 and treated with combination of retinoids, imiquimod and quadrivalent HPV vaccine. ( 26047065 )
2015
7
Molecular Biology for HPV Typing in Focal Epithelial Hyperplasia. ( 26456971 )
2015
8
Extensive Focal Epithelial Hyperplasia: A Case Report. ( 26351501 )
2015
9
Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family. ( 24738569 )
2014
10
Focal epithelial hyperplasia in a human immuno-deficiency virus patient treated with laser surgery. ( 25032206 )
2014
11
Focal epithelial hyperplasia in a Turkish family. ( 25551850 )
2014
12
Focal epithelial hyperplasia arising after delivery of metal-ceramic fixed dental prosthesis. ( 25558348 )
2014
13
Oral Focal Epithelial Hyperplasia: Report of Three Cases. ( 24585348 )
2014
14
Focal epithelial hyperplasia (Heck's disease): a case report and review. ( 24706245 )
2014
15
Focal epithelial hyperplasia - an update. ( 23061874 )
2013
16
Focal epithelial hyperplasia. ( 24269109 )
2013
17
Human papillomavirus-32-associated focal epithelial hyperplasia accompanying HPV-16-positive papilloma-like lesions in oral mucosa. ( 23714908 )
2013
18
Focal epithelial hyperplasia (Heck's disease). ( 24353818 )
2013
19
Focal epithelial hyperplasia (Heck's disease) in two Chinese females. ( 22154527 )
2012
20
Oral medicine case book 43--focal epithelial hyperplasia in an HIV-seropositive child. ( 23951749 )
2012
21
Dermacase. Can you identify this condition? Focal epithelial hyperplasia. ( 22170197 )
2011
22
Focal epithelial hyperplasia: Case report. ( 22071419 )
2011
23
Oral focal epithelial hyperplasia: report of 3 cases with human papillomavirus DNA sequencing analysis. ( 22353414 )
2011
24
A Case Report of Focal Epithelial Hyperplasia (Heck's disease) with PCR Detection of Human Papillomavirus. ( 23204755 )
2011
25
Focal epithelial hyperplasia (Heck's Disease) in two siblings: response to treatment with imiquimod 5% cream. ( 20172842 )
2010
26
Focal epithelial hyperplasia caused by human papillomavirus 13. ( 20508479 )
2010
27
Oral focal epithelial hyperplasia. ( 20863043 )
2010
28
Focal epithelial hyperplasia (Heck disease) related to highly active antiretroviral therapy in an HIV-seropositive child. A report of a case, and a review of the literature. ( 20632701 )
2010
29
Extensive focal epithelial hyperplasia. ( 20039770 )
2010
30
Case of the month. Heck's disease (focal epithelial hyperplasia). ( 19405233 )
2009
31
Detection of human papilloma virus DNA in seven cases of focal epithelial hyperplasia in Iran. ( 19453844 )
2009
32
Focal epithelial hyperplasia: polymerase chain reaction amplification as a differential diagnosis tool. ( 19155739 )
2009
33
Treatment of focal epithelial hyperplasia with topical imiquimod: report of three cases. ( 19689526 )
2009
34
Induction of focal epithelial hyperplasia in tongue of young bk6-E6/E7 HPV16 transgenic mice. ( 19165615 )
2009
35
An uncommon focal epithelial hyperplasia manifestation. ( 19941767 )
2009
36
Focal epithelial hyperplasia (Heck disease) in a black child. ( 17845152 )
2007
37
Oral pathology quiz #51. Case number 4. Focal epithelial hyperplasia. ( 16800060 )
2006
38
General practitioner's pathology case 9. Focal epithelial hyperplasia. ( 17201309 )
2006
39
What is your diagnosis? Focal epithelial hyperplasia (Heck disease). ( 16706237 )
2006
40
Oral focal epithelial hyperplasia: report of five cases. ( 16721472 )
2006
41
Focal epithelial hyperplasia (Heck's disease): report of a case in a girl of Brazilian Indian descent. ( 16364096 )
2006
42
Molecular and serological evidence of the epidemiological association of HPV 13 with focal epithelial hyperplasia: a case-control study. ( 16793332 )
2006
43
Focal epithelial hyperplasia. A rare disease in our area. ( 15735545 )
2005
44
Oral pathology quiz #48. Case number 2. Focal epithelial hyperplasia. ( 16795955 )
2005
45
Extensive focal epithelial hyperplasia: case report. ( 16324231 )
2005
46
Clinical, histopathological and virological findings in patients with focal epithelial hyperplasia from Colombia. ( 15811076 )
2005
47
Association of HLA-DR4 (DRB1*0404) with human papillomavirus infection in patients with focal epithelial hyperplasia. ( 15492185 )
2004
48
Focal epithelial hyperplasia (Heck's disease): report of two cases with PCR detection of human papillomavirus DNA. ( 15196147 )
2004
49
[Imiquimod for the topical treatment of focal epithelial hyperplasia (Heck disease) in a child]. ( 16281588 )
2004
50
Oral pathology quiz # 42. Case 1. Focal epithelial hyperplasia. ( 15160430 )
2004

Variations for Focal Epithelial Hyperplasia

Expression for Focal Epithelial Hyperplasia

Search GEO for disease gene expression data for Focal Epithelial Hyperplasia.

Pathways for Focal Epithelial Hyperplasia

Pathways related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.62 HLA-DQA1 HLA-DQB1 HLA-DRB1
2
Show member pathways
12.58 HLA-DQA1 HLA-DQB1 HLA-DRB1
3
Show member pathways
12.53 HLA-DQA1 HLA-DQB1 HLA-DRB1
4
Show member pathways
12.47 HLA-DQA1 HLA-DQB1 HLA-DRB1
5
Show member pathways
12.47 HLA-DQA1 HLA-DQB1 HLA-DRB1
6
Show member pathways
12.32 HLA-DQA1 HLA-DQB1 HLA-DRB1
7
Show member pathways
12.26 HLA-DQA1 HLA-DQB1 HLA-DRB1
8
Show member pathways
12.17 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 12.15 HLA-DQA1 HLA-DQB1 HLA-DRB1
10
Show member pathways
12.11 HLA-DQA1 HLA-DQB1 HLA-DRB1
11
Show member pathways
12.07 HLA-DQA1 HLA-DQB1 HLA-DRB1
12 12.02 HLA-DQA1 HLA-DQB1 HLA-DRB1
13
Show member pathways
11.97 HLA-DQA1 HLA-DQB1 HLA-DRB1
14 11.94 HLA-DQA1 HLA-DQB1 HLA-DRB1
15
Show member pathways
11.91 HLA-DQA1 HLA-DQB1 HLA-DRB1
16 11.84 HLA-DQA1 HLA-DQB1 HLA-DRB1
17
Show member pathways
11.82 HLA-DQA1 HLA-DQB1 HLA-DRB1
18 11.77 HLA-DQA1 HLA-DQB1 HLA-DRB1
19 11.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
20
Show member pathways
11.58 HLA-DQA1 HLA-DQB1 HLA-DRB1
21 11.51 HLA-DQA1 HLA-DQB1 HLA-DRB1
22 11.42 HLA-DQA1 HLA-DQB1 HLA-DRB1
23 11.29 HLA-DQA1 HLA-DQB1 HLA-DRB1
24 10.98 HLA-DQA1 HLA-DQB1 HLA-DRB1
25 10.55 HLA-DQA1 HLA-DQB1 HLA-DRB1

GO Terms for Focal Epithelial Hyperplasia

Cellular components related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Golgi membrane GO:0000139 9.65 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 lysosomal membrane GO:0005765 9.63 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 endosome membrane GO:0010008 9.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 trans-Golgi network membrane GO:0032588 9.58 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 endocytic vesicle membrane GO:0030666 9.54 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-DQA1 HLA-DQB1 HLA-DRB1
7 transport vesicle membrane GO:0030658 9.43 HLA-DQA1 HLA-DQB1 HLA-DRB1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
10 MHC class II protein complex GO:0042613 8.8 HLA-DQA1 HLA-DQB1 HLA-DRB1

Biological processes related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.63 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 T cell receptor signaling pathway GO:0050852 9.61 HLA-DQA1 HLA-DQB1 HLA-DRB1
3 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.58 HLA-DQA1 HLA-DQB1 HLA-DRB1
4 T cell costimulation GO:0031295 9.5 HLA-DQA1 HLA-DQB1 HLA-DRB1
5 interferon-gamma-mediated signaling pathway GO:0060333 9.43 HLA-DQA1 HLA-DQB1 HLA-DRB1
6 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.37 HLA-DQB1 HLA-DRB1
7 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.16 HLA-DQB1 HLA-DRB1
8 antigen processing and presentation GO:0019882 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
9 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 8.8 HLA-DQA1 HLA-DQB1 HLA-DRB1

Molecular functions related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide antigen binding GO:0042605 9.13 HLA-DQA1 HLA-DQB1 HLA-DRB1
2 MHC class II receptor activity GO:0032395 8.8 HLA-DQA1 HLA-DQB1 HLA-DRB1

Sources for Focal Epithelial Hyperplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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