MCID: FCL010
MIFTS: 37

Focal Epithelial Hyperplasia

Categories: Infectious diseases, Oral diseases

Aliases & Classifications for Focal Epithelial Hyperplasia

MalaCards integrated aliases for Focal Epithelial Hyperplasia:

Name: Focal Epithelial Hyperplasia 12 54 44 15 17 70
Multifocal Epithelial Hyperplasia 12
Heck's Disease 12
Heck Disease 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5362
MeSH 44 D017573
NCIt 50 C97083
SNOMED-CT 67 36949004
UMLS 70 C0206067

Summaries for Focal Epithelial Hyperplasia

Disease Ontology : 12 A viral infectious disease that results in infection located in mouth, has material basis in human papillomavirus (types 13 or 32), has symptom papules or nodules in the oral cavity.

MalaCards based summary : Focal Epithelial Hyperplasia, also known as multifocal epithelial hyperplasia, is related to focal epithelial hyperplasia, oral and focal epithelial hyperplasia of the oral mucosa, and has symptoms including papules and oral manifestations. An important gene associated with Focal Epithelial Hyperplasia is HLA-DRB1 (Major Histocompatibility Complex, Class II, DR Beta 1), and among its related pathways/superpathways are Measles and ICos-ICosL Pathway in T-Helper Cell. Affiliated tissues include mouth, prostate and bone marrow.

Wikipedia : 73 Heck's disease, also known as Focal Epithelial Hyperplasia, is an asymptomatic, benign neoplastic... more...

Related Diseases for Focal Epithelial Hyperplasia

Diseases related to Focal Epithelial Hyperplasia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 focal epithelial hyperplasia, oral 11.6
2 focal epithelial hyperplasia of the oral mucosa 11.3
3 papilloma 10.6
4 squamous cell papilloma 10.6
5 limbic encephalitis with lgi1 antibodies 10.3 HLA-DRB1 HLA-DQB1
6 autoimmune polyglandular syndrome type 3 10.3 HLA-DRB1 HLA-DQB1
7 idiopathic hypersomnia 10.3 HLA-DRB1 HLA-DQB1
8 hypersomnia 10.3 HLA-DRB1 HLA-DQB1
9 narcolepsy 2 10.3 HLA-DRB1 HLA-DQB1
10 htlv-1 associated myelopathy/tropical spastic paraparesis 10.3 HLA-DRB1 HLA-DQB1
11 latent autoimmune diabetes in adults 10.3 HLA-DRB1 HLA-DQB1
12 occupational asthma 10.3 HLA-DRB1 HLA-DQB1
13 recurrent respiratory papillomatosis 10.3 HLA-DRB1 HLA-DQB1
14 beryllium disease 10.3 HLA-DRB1 HLA-DQB1
15 achalasia, familial esophageal 10.3 HLA-DQB1 HLA-DQA1
16 apple allergy 10.3 HLA-DRB1 HLA-DQB1
17 chronic beryllium disease 10.3 HLA-DRB1 HLA-DQB1
18 metal allergy 10.3 HLA-DRB1 HLA-DQB1
19 pediatric multiple sclerosis 10.3 HLA-DRB1 HLA-DQB1
20 pemphigoid 10.3 HLA-DRB1 HLA-DQB1
21 osteonecrosis of the jaw 10.3 HLA-DRB1 HLA-DQB1
22 pityriasis rosea 10.3 HLA-DRB1 HLA-DQB1
23 shrimp allergy 10.3 HLA-DQB1 HLA-DQA1
24 eosinophilia-myalgia syndrome 10.3 HLA-DRB1 HLA-DQA1
25 narcolepsy 1 10.3 HLA-DRB1 HLA-DQB1
26 idiopathic nephrotic syndrome 10.3 HLA-DRB1 HLA-DQB1
27 ocular cicatricial pemphigoid 10.3 HLA-DRB1 HLA-DQB1
28 cicatricial pemphigoid 10.3 HLA-DRB1 HLA-DQB1
29 alveolar echinococcosis 10.3 HLA-DRB1 HLA-DQB1
30 paraneoplastic pemphigus 10.2 HLA-DRB1 HLA-DQB1
31 sympathetic ophthalmia 10.2 HLA-DRB1 HLA-DQA1
32 congenital toxoplasmosis 10.2 HLA-DQB1 HLA-DQA1
33 histoplasmosis 10.2 HLA-DRB1 HLA-DQA1
34 cytomegalovirus retinitis 10.2 HLA-DRB1 HLA-DQB1
35 cystic echinococcosis 10.2 HLA-DRB1 HLA-DQB1
36 angiokeratoma of fordyce 10.2 TMC8 TMC6
37 pure red-cell aplasia 10.2 HLA-DRB1 HLA-DQB1
38 plantar wart 10.2 TMC8 TMC6
39 trachoma 10.2 HLA-DRB1 HLA-DQB1
40 common wart 10.2 TMC8 TMC6
41 microscopic colitis 10.2 HLA-DRB1 HLA-DQB1
42 inverted follicular keratosis 10.2 GP6 GP5
43 autoimmune gastritis 10.2 HLA-DRB1 HLA-DQB1
44 pityriasis versicolor 10.2 TMC8 TMC6
45 superficial mycosis 10.2 TMC8 TMC6
46 hirata disease 10.2 TNFRSF10A HLA-DRB1
47 chronic cervicitis 10.2 GP6 GP5
48 cervicitis 10.2 GP6 GP5
49 primary adrenal insufficiency 10.2 HLA-DRB1 HLA-DQB1 HLA-DQA1
50 autoimmune hepatitis type 1 10.2 HLA-DRB1 HLA-DQB1 HLA-DQA1

Graphical network of the top 20 diseases related to Focal Epithelial Hyperplasia:



Diseases related to Focal Epithelial Hyperplasia

Symptoms & Phenotypes for Focal Epithelial Hyperplasia

Symptoms:

12
  • papules

UMLS symptoms related to Focal Epithelial Hyperplasia:


oral manifestations

Drugs & Therapeutics for Focal Epithelial Hyperplasia

Search Clinical Trials , NIH Clinical Center for Focal Epithelial Hyperplasia

Cochrane evidence based reviews: focal epithelial hyperplasia

Genetic Tests for Focal Epithelial Hyperplasia

Anatomical Context for Focal Epithelial Hyperplasia

The Foundational Model of Anatomy Ontology organs/tissues related to Focal Epithelial Hyperplasia:

19
Mouth

MalaCards organs/tissues related to Focal Epithelial Hyperplasia:

40
Prostate, Bone Marrow, Bone, Smooth Muscle, Kidney, Pancreas, Thyroid

Publications for Focal Epithelial Hyperplasia

Articles related to Focal Epithelial Hyperplasia:

(show top 50) (show all 299)
# Title Authors PMID Year
1
Focal epithelial hyperplasia treated with interferon alpha-2a. 61 54
12243669 2001
2
Heck's disease occurring after Epstein-Barr virus-associated smooth muscle tumors in an immunosuppressed child. 61
33275301 2021
3
Unusual oral multifocal epithelial hyperplasia in an adult African-American lung transplant patient. 61
33095955 2020
4
Genomic characterization of human papillomavirus type 13, associated to multifocal epithelial hyperplasia, in a Mayan community. 61
33096300 2020
5
Dermoscopy of Focal Epithelial Hyperplasia. 61
33165385 2020
6
Human genetic dissection of papillomavirus-driven diseases: new insight into their pathogenesis. 61
32435828 2020
7
The molecular-based differentiation of Heck's disease from its mimics including oral condyloma and white sponge nevus. 61
31473371 2019
8
Great diversity of oncogenic human papillomaviruses is revealed in an outbreak of multifocal epithelial hyperplasia. 61
31881297 2019
9
Oral Multifocal Epithelial Hyperplasia: An Unusual Entity. 61
31681555 2019
10
Focal Epithelial Hyperplasia in a Child with Hereditary Sensory and Autonomic Neuropathy type IV: A Rare Co-Occurrence. 61
31645257 2019
11
Benign epithelial oral lesions - association with human papillomavirus. 61
31011139 2019
12
HPV-Related Papillary Lesions of the Oral Mucosa: A Review. 61
30693456 2019
13
[Immunohistochemical study of Ki-67, PHH3, and CK15 protein expression in oral epithelial malignancy]. 61
31626202 2019
14
Disease Manifestation and Viral Sequences in a Bonobo More Than 30 Years after Papillomavirus Infection. 61
30691118 2019
15
Multifocal epithelial hyperplasia (Heck disease) in a 7-year-old boy. 61
30559281 2018
16
Laser Excision of Focal Epithelial Hyperplasia (Heck's Disease): A Rare Case Report. 61
31303742 2018
17
Oral manifestations of human papillomavirus infections. 61
30178562 2018
18
Human papillomavirus load in benign HPV-associated oral lesions from HIV/AIDS individuals. 61
29480634 2018
19
Use of trichloroacetic acid for management of oral lesions caused by human papillomavirus. 61
29513235 2018
20
Unusually high incidence of multifocal epithelial hyperplasia in children of the Nahuatl population of Mexico. 61
28799531 2017
21
Multifocal Epithelial Hyperplasia. 61
28387191 2017
22
Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13. 61
27882674 2016
23
Multifocal epithelial hyperplasia: a forgotten condition in the elderly. 61
27599286 2016
24
Case Report of Focal Epithelial Hyperplasia (Heck's Disease) with Polymerase Chain Reaction Detection of Human Papillomavirus 13. 61
27072123 2016
25
Focal Epithelial Hyperplasia (Heck's Disease) in a 57-Year-Old Brazilian Patient: A Case Report and Literature Review. 61
26985258 2016
26
Exophytic Verrucous Hyperplasia of the Oral Cavity – Application of Standardized Criteria for Diagnosis from a Consensus Report 61
27865210 2016
27
Papilloma of lip associated with human papilloma viruses-32 infection in a child. 61
26776129 2016
28
Focal Epithelial Hyperplasia in Adult Patients With HIV Infection: Clearance With Topical Imiquimod. 61
27871359 2016
29
Pediatric Dermatology Photoquiz: Multiple Papules on the Mucosal Surfaces of a 17-Year-Old Boy. Focal epithelial hyperplasia (Heck's disease). 61
26758095 2016
30
[Value of the expression of Ki-67 and membrane protein glucose transporter GLUT1 in the diagnosis of neoplastic transformation of the oral mucosal epithelium]. 61
27804941 2016
31
Focal epithelial hyperplasia by human papillomavirus (HPV)-32 misdiagnosed as HPV-16 and treated with combination of retinoids, imiquimod and quadrivalent HPV vaccine. 61
26047065 2015
32
Human papillomavirus detection in histologic samples of multifocal epithelial hyperplasia: a novel demographic presentation. 61
26455288 2015
33
HPV and oral lesions: preventive possibilities, vaccines and early diagnosis of malignant lesions. 61
27555904 2015
34
Focal epithelial hyperplasia associated with human papillomavirus 13 and common human leukocyte antigen alleles in a Turkish family. 61
24738569 2015
35
Oral focal epithelial hyperplasia: report of three cases. 61
24585348 2015
36
Molecular Biology for HPV Typing in Focal Epithelial Hyperplasia. 61
26456971 2015
37
Extensive Focal Epithelial Hyperplasia: A Case Report. 61
26351501 2015
38
Human papillomavirus and Epstein-Barr virus associated conditions of the oral mucosa. 61
25749203 2015
39
Focal epithelial hyperplasia arising after delivery of metal-ceramic fixed dental prosthesis. 61
25558348 2014
40
Focal epithelial hyperplasia in a Turkish family. 61
25551850 2014
41
Multifocal epithelial hyperplasia: report of 3 cases. 61
25148288 2014
42
Multifocal epithelial hyperplasia (Heck disease) in a patient with chronic lymphocytic leukemia. 61
24754486 2014
43
Focal epithelial hyperplasia. 61
24269109 2014
44
Focal epithelial hyperplasia in a human immuno-deficiency virus patient treated with laser surgery. 61
25032206 2014
45
Focal epithelial hyperplasia (Heck's disease): a case report and review. 61
24706245 2014
46
The role of human papillomavirus in oral disease. 61
24655529 2014
47
Treatment of multifocal epithelial hyperplasia with imiquimod. 61
24685868 2014
48
HPV oral lesions in HIV-infected patients: the impact of long-term HAART. 61
23278731 2013
49
Focal epithelial hyperplasia - an update. 61
23061874 2013
50
Human papillomavirus-32-associated focal epithelial hyperplasia accompanying HPV-16-positive papilloma-like lesions in oral mucosa. 61
23714908 2013

Variations for Focal Epithelial Hyperplasia

Expression for Focal Epithelial Hyperplasia

Search GEO for disease gene expression data for Focal Epithelial Hyperplasia.

Pathways for Focal Epithelial Hyperplasia

Pathways related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.54 TNFRSF10A HLA-DRB1 HLA-DQB1 HLA-DQA1
2
Show member pathways
12.13 HLA-DRB1 HLA-DQB1 HLA-DQA1
3
Show member pathways
12.09 HLA-DRB1 HLA-DQB1 HLA-DQA1
4 12.07 HLA-DRB1 HLA-DQB1 HLA-DQA1
5
Show member pathways
12 HLA-DRB1 HLA-DQB1 HLA-DQA1
6 11.97 HLA-DRB1 HLA-DQB1 HLA-DQA1
7
Show member pathways
11.92 HLA-DRB1 HLA-DQB1 HLA-DQA1
8 11.85 HLA-DRB1 HLA-DQB1 HLA-DQA1
9 11.81 HLA-DRB1 HLA-DQB1 HLA-DQA1
10 11.64 HLA-DRB1 HLA-DQB1 HLA-DQA1
11
Show member pathways
11.62 HLA-DRB1 HLA-DQB1 HLA-DQA1
12 11.56 HLA-DRB1 HLA-DQB1 HLA-DQA1
13 11.47 HLA-DRB1 HLA-DQB1 HLA-DQA1
14
Show member pathways
11.29 HLA-DRB1 HLA-DQB1 HLA-DQA1
15 11.28 HLA-DRB1 HLA-DQB1 HLA-DQA1
16 11.25 HLA-DRB1 HLA-DQB1 HLA-DQA1 GP5
17 10.91 KRT15 HLA-DRB1 HLA-DQB1 HLA-DQA1
18 10.55 GP6 GP5

GO Terms for Focal Epithelial Hyperplasia

Cellular components related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.13 TNFRSF10A TMC6 RAB3C MARK3 HLA-DRB1 HLA-DQB1
2 extracellular exosome GO:0070062 9.98 TMC8 TMC6 MARK3 KRT15 HLA-DRB1 GP6
3 integral component of plasma membrane GO:0005887 9.93 TMC8 TMC6 HLA-DRB1 HLA-DQA1 GP6 GP5
4 trans-Golgi network membrane GO:0032588 9.58 HLA-DRB1 HLA-DQB1 HLA-DQA1
5 endocytic vesicle membrane GO:0030666 9.54 HLA-DRB1 HLA-DQB1 HLA-DQA1
6 ER to Golgi transport vesicle membrane GO:0012507 9.5 HLA-DRB1 HLA-DQB1 HLA-DQA1
7 transport vesicle membrane GO:0030658 9.43 HLA-DRB1 HLA-DQB1 HLA-DQA1
8 clathrin-coated endocytic vesicle membrane GO:0030669 9.33 HLA-DRB1 HLA-DQB1 HLA-DQA1
9 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 9.13 HLA-DRB1 HLA-DQB1 HLA-DQA1
10 MHC class II protein complex GO:0042613 8.8 HLA-DRB1 HLA-DQB1 HLA-DQA1

Biological processes related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.61 HLA-DRB1 HLA-DQB1 HLA-DQA1
2 antigen processing and presentation of exogenous peptide antigen via MHC class II GO:0019886 9.54 HLA-DRB1 HLA-DQB1 HLA-DQA1
3 interferon-gamma-mediated signaling pathway GO:0060333 9.5 HLA-DRB1 HLA-DQB1 HLA-DQA1
4 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.4 TNFRSF10A TMC8
5 humoral immune response mediated by circulating immunoglobulin GO:0002455 9.26 HLA-DRB1 HLA-DQB1
6 immunoglobulin production involved in immunoglobulin mediated immune response GO:0002381 9.16 HLA-DRB1 HLA-DQB1
7 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.13 HLA-DRB1 HLA-DQB1 HLA-DQA1
8 antigen processing and presentation GO:0019882 8.92 RAB3C HLA-DRB1 HLA-DQB1 HLA-DQA1

Molecular functions related to Focal Epithelial Hyperplasia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mechanosensitive ion channel activity GO:0008381 9.16 TMC8 TMC6
2 peptide antigen binding GO:0042605 9.13 HLA-DRB1 HLA-DQB1 HLA-DQA1
3 MHC class II receptor activity GO:0032395 8.8 HLA-DRB1 HLA-DQB1 HLA-DQA1

Sources for Focal Epithelial Hyperplasia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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