MCID: FCL049
MIFTS: 36

Focal Hand Dystonia

Categories: Muscle diseases, Neuronal diseases

Aliases & Classifications for Focal Hand Dystonia

MalaCards integrated aliases for Focal Hand Dystonia:

Name: Focal Hand Dystonia 12 15
Organic Writer's Cramp 12 73
Dystonia, Focal, Task-Specific 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0050841
ICD9CM 35 333.84
MeSH 44 D020821

Summaries for Focal Hand Dystonia

Disease Ontology : 12 A focal dystonia that affects a single muscle or small group of muscles in the hand resulting from involuntary muscular contractions.

MalaCards based summary : Focal Hand Dystonia, also known as organic writer's cramp, is related to focal dystonia and dystonia, and has symptoms including ataxia and spasmodic torticollis. An important gene associated with Focal Hand Dystonia is TOR1A (Torsin Family 1 Member A). The drugs Acetylcholine and abobotulinumtoxinA have been mentioned in the context of this disorder. Affiliated tissues include brain, cortex and testes, and related phenotypes are mortality/aging and renal/urinary system

Related Diseases for Focal Hand Dystonia

Graphical network of the top 20 diseases related to Focal Hand Dystonia:



Diseases related to Focal Hand Dystonia

Symptoms & Phenotypes for Focal Hand Dystonia

UMLS symptoms related to Focal Hand Dystonia:


ataxia, spasmodic torticollis

MGI Mouse Phenotypes related to Focal Hand Dystonia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.81 CAMP DRD5 EDC4 PANK2 PDGFB RIMS2
2 renal/urinary system MP:0005367 9.35 CTBS DRD5 PANK2 PDE8B PDGFB
3 vision/eye MP:0005391 9.17 THAP1 TOR1A VIM CAMP DRD5 PANK2

Drugs & Therapeutics for Focal Hand Dystonia

Drugs for Focal Hand Dystonia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Acetylcholine Approved Phase 3,Phase 1,Phase 2,Not Applicable 51-84-3 187
2 abobotulinumtoxinA Phase 3,Not Applicable
3 Botulinum Toxins Phase 3,Phase 1,Phase 2,Not Applicable
4 Botulinum Toxins, Type A Phase 3,Not Applicable
5 Cholinergic Agents Phase 3,Phase 1,Phase 2,Not Applicable
6 Neuromuscular Agents Phase 3,Phase 2
7 Neurotransmitter Agents Phase 3,Phase 1,Phase 2,Not Applicable
8 onabotulinumtoxinA Phase 3,Not Applicable
9 Peripheral Nervous System Agents Phase 3,Phase 2
10
Amlodipine Approved Phase 2 88150-42-9 2162
11
Mexiletine Approved, Investigational Phase 2 31828-71-4 4178
12 Antihypertensive Agents Phase 2
13 calcium channel blockers Phase 2
14 Calcium, Dietary Phase 2
15 Vasodilator Agents Phase 2
16 Anti-Arrhythmia Agents Phase 2
17 Diuretics, Potassium Sparing Phase 2
18 Sodium Channel Blockers Phase 2
19 incobotulinumtoxinA Phase 2
20
Flumazenil Approved 78755-81-4 3373
21 Dihydroxyphenylalanine

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Comparison of Electrophysiologic and Ultrasound Guidance for Onabotulinum Toxin A Injections in Focal Upper Extremity Dystonia and Spasticity Recruiting NCT02326818 Phase 3
2 Transcranial Electrical Polarization to Treat Focal Hand Dystonia Completed NCT00106782 Phase 2
3 rTMS and Retraining in Focal Hand Dystonia Completed NCT01738581 Phase 1, Phase 2
4 Motor Training to Treat Hand Dystonia Completed NCT00021853 Phase 2
5 Pilot Trial of Botulinum Toxin and Occupational Therapy for Writer's Cramp Completed NCT02015039 Phase 1, Phase 2 BoNT Injections
6 Brain Stimulation to Treat Blepharospasm or Meige Syndrome Completed NCT00411255 Phase 2
7 Amlodipine Plus Botulinum Toxin for Focal Dystonia Completed NCT00015457 Phase 2 Amlodipine plus Botulinum toxin
8 Mexiletine for the Treatment of Focal Dystonia Completed NCT00001784 Phase 2 Mexiletine
9 Deep Brain Stimulation Surgery for Focal Hand Dystonia Recruiting NCT02911103 Phase 1, Phase 2
10 Incobotulinum Toxin A (Xeomin®) As A Treatment For Focal Task-Specific Dystonia Of The Musician's Hand Recruiting NCT02107261 Phase 2 incobotulinumtoxin A
11 Repetitive Transcranial Magnetic Stimulation for the Treatment of Focal Hand Dystonia Completed NCT01884064 Phase 1
12 Somatosensory Processing in Focal Hand Dystonia Unknown status NCT00579033 Not Applicable
13 Inhibitory rTMS in Dystonic Wilson Patients Unknown status NCT01980433 Not Applicable
14 Long-Term Motor Learning in Focal Hand Dystonia Completed NCT00325091
15 Muscle Contraction in Patients With Focal Hand Dystonia Completed NCT00376753
16 Neurophysiology of Task-Specificity of Focal Hand Dystonia Completed NCT00309010
17 Brain Changes in Patients With Focal Hand Dystonia Completed NCT00306865
18 fMRI Studies of Task Specificity in Focal Hand Dystonia Completed NCT00310414
19 Movement-Related Brain Networks Involved in Hand Dystonia Completed NCT00137384
20 EEG and EMG Studies of Hand Dystonia Completed NCT00025701
21 Transcranial Magnetic Stimulation and Electrical Stimulation of Nerves to Study Focal Dystonia Completed NCT00050024
22 Sensory Training to Treat Focal Dystonia Completed NCT00006336
23 Validating a New Writer s Cramp Scale Completed NCT01579266
24 Association Between Focal Dystonia and Complex Regional Pain Syndrome Completed NCT00595439
25 Task-dependent Operation of a Mechanism Intracortical Inhibition in Dystonia Completed NCT03381456 Not Applicable
26 Effects of Botulinum Toxin in Cervical Dystonia Completed NCT01056861 Botulinum Toxin A
27 Survey of Sensory and Motor Tricks in Focal Dystonia Completed NCT00054652
28 Effect of Increasing Motor Cortex Inhibition on Task Specific Dystonia Recruiting NCT01823237 Not Applicable
29 Pathophysiology of Dystonia and Complex Regional Pain Syndrome Recruiting NCT03223623
30 Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal Dystonia Recruiting NCT02334683 Not Applicable
31 Validation of the Zigzag Tracking Task Test for the Evaluation of Handwriting Difficulties in Writer's Cramp Recruiting NCT02882295
32 Sensorimotor Mapping in Patients With Writer's Cramp Recruiting NCT03085745 Not Applicable
33 Finger Individuation Training With a Training Device Versus Conventional Rehabilitation for Writer's Cramp Recruiting NCT02882334 Not Applicable
34 Propensity to Develop Plasticity in the Parieto- and Cerebello-Motor Networks in Dystonia From the Perspective of Abnormal High-Order Motor Processing Recruiting NCT02504905
35 The Dystonia Coalition Natural History and Biospecimen Repository for Isolated Dystonias Recruiting NCT01373424
36 Botulinum Toxin for the Treatment of Involuntary Movement Disorders Recruiting NCT00001208 Not Applicable
37 Brain Networks in Dystonia Enrolling by invitation NCT03042962
38 Transcranial Magnetic Stimulation for Focal Hand Dystonia Suspended NCT01792336
39 Depotentiation in People With Focal Hand Dystonia Terminated NCT02106936
40 Brain Anatomy in Dystonia Terminated NCT00031369

Search NIH Clinical Center for Focal Hand Dystonia

Genetic Tests for Focal Hand Dystonia

Anatomical Context for Focal Hand Dystonia

MalaCards organs/tissues related to Focal Hand Dystonia:

41
Brain, Cortex, Testes, Cerebellum

Publications for Focal Hand Dystonia

Articles related to Focal Hand Dystonia:

(show all 43)
# Title Authors Year
1
Quantitative Assessment of Hand Dysfunction in Patients with Early Parkinson's Disease and Focal Hand Dystonia. ( 29316781 )
2018
2
Loss of inhibition in sensorimotor networks in focal hand dystonia. ( 29062685 )
2018
3
Neuromuscular Re-Education Programs for Musicians with Focal Hand Dystonia: A Systematic Review. ( 29868689 )
2018
4
Cathodal Transcranial Direct Current Stimulation Improves Focal Hand Dystonia in Musicians: A Two-Case Study. ( 28955194 )
2017
5
A prognostic factor in focal hand dystonia: typist's cramp cases and literature review. ( 27871456 )
2016
6
A neuromorphic model of motor overflow in focal hand dystonia due to correlated sensory input. ( 27578228 )
2016
7
Non-Invasive Brain Stimulation for Treatment of Focal Hand Dystonia: Update and Future Direction. ( 27240806 )
2016
8
An unusual cause of focal hand dystonia due to a retained implant of the distal radius. ( 26746833 )
2016
9
Haptic Feedback Manipulation During Botulinum Toxin Injection Therapy for Focal Hand Dystonia Patients: A Possible New Assistive Strategy. ( 27552765 )
2016
10
Objective Evaluation of Performance Stress in Musicians With Focal Hand Dystonia: A Case Series. ( 27715491 )
2016
11
Haptic Feedback Manipulation During Botulinum Toxin Injection Therapy for Focal Hand Dystonia Patients: A Possible New Assistive Strategy. ( 28113638 )
2016
12
A practical approach to management of focal hand dystonia. ( 26019409 )
2015
13
Mixed effectiveness of rTMS and retraining in the treatment of focal hand dystonia. ( 26217209 )
2015
14
Anodal transcranial direct current stimulation to the cerebellum improves handwriting and cyclic drawing kinematics in focal hand dystonia. ( 26042019 )
2015
15
Focal hand dystonia: individualized intervention with repeated application of repetitive transcranial magnetic stimulation. ( 25256555 )
2014
16
Normalizing Biased Spatial Attention With Parietal rTMS in a Patient With Focal Hand Dystonia. ( 25178660 )
2014
17
Sensory abnormalities in focal hand dystonia and non-invasive brain stimulation. ( 25538594 )
2014
18
Primary somatosensory cortical plasticity and tactile temporal discrimination in focal hand dystonia. ( 24012050 )
2014
19
A multifactorial conceptual model of peripheral neuromusculoskeletal predisposing factors in task-specific focal hand dystonia in musicians: etiologic and therapeutic implications. ( 25323627 )
2014
20
Multiple changes of functional connectivity between sensorimotor areas in focal hand dystonia. ( 24706945 )
2014
21
Focal hand dystonia: using brain stimulation to probe network interactions and brain plasticity. ( 25042177 )
2014
22
Complex-value coherence mapping reveals novel abnormal resting-state functional connectivity networks in task-specific focal hand dystonia. ( 24133480 )
2013
23
Treatment effectiveness of brain-computer interface training for patients with focal hand dystonia: A double-case study. ( 24109677 )
2013
24
Alteration in forward model prediction of sensory outcome of motor action in focal hand dystonia. ( 23882198 )
2013
25
Abnormal movement preparation in task-specific focal hand dystonia. ( 24167610 )
2013
26
Abnormal experimentally- and behaviorally-induced LTP-like plasticity in focal hand dystonia. ( 23142185 )
2013
27
A combination of constraint-induced therapy and motor control retraining in the treatment of focal hand dystonia in musicians: a long-term follow-up study. ( 23462903 )
2013
28
Focal hand dystonia in musicians: a synopsis. ( 23515596 )
2013
29
Utility of multi-channel surface electromyography in assessment of focal hand dystonia. ( 23861190 )
2013
30
Aristotle's illusion reveals interdigit functional somatosensory alterations in focal hand dystonia. ( 23404333 )
2013
31
Multiple sessions of low-frequency repetitive transcranial magnetic stimulation in focal hand dystonia: clinical and physiological effects. ( 23340117 )
2013
32
Temporal expectation in focal hand dystonia. ( 23361064 )
2013
33
Individuated finger control in focal hand dystonia: an fMRI study. ( 22484405 )
2012
34
Differential activation in the primary motor cortex during individual digit movement in focal hand dystonia vs. healthy. ( 22451345 )
2012
35
Aberrant Oscillatory Activity during Simple Movement in Task-Specific Focal Hand Dystonia. ( 23226140 )
2012
36
Psychiatric symptoms associated with focal hand dystonia. ( 20737548 )
2010
37
Difference in intracortical inhibition of the motor cortex between cortical myoclonus and focal hand dystonia. ( 18387338 )
2008
38
Effect of thalamotomy on focal hand dystonia in a family with DYT1 mutation. ( 18823049 )
2008
39
Focal hand dystonia in a patient with PANK2 mutation. ( 18074375 )
2008
40
Focal hand dystonia secondary to Basal Ganglia germinoma. ( 19513283 )
2007
41
Treatment of cervical dystonia and focal hand dystonia by high cervical continuously infused intrathecal baclofen: a report of 2 cases. ( 15827940 )
2005
42
Motor training as treatment in focal hand dystonia. ( 15486996 )
2005
43
Focal hand dystonia in a patient with thoracic outlet syndrome. ( 9703190 )
1998

Variations for Focal Hand Dystonia

Expression for Focal Hand Dystonia

Search GEO for disease gene expression data for Focal Hand Dystonia.

Pathways for Focal Hand Dystonia

GO Terms for Focal Hand Dystonia

Biological processes related to Focal Hand Dystonia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 reactive oxygen species metabolic process GO:0072593 8.96 DRD5 PDGFB
2 negative regulation of blood pressure GO:0045776 8.62 DRD5 RNPEP

Sources for Focal Hand Dystonia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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