MCID: FLC001
MIFTS: 29

Folic Acid Deficiency Anemia

Categories: Immune diseases, Blood diseases, Metabolic diseases

Aliases & Classifications for Folic Acid Deficiency Anemia

MalaCards integrated aliases for Folic Acid Deficiency Anemia:

Name: Folic Acid Deficiency Anemia 12 15
Megaloblastic Anemia Due to Folate Deficiency 73
Folate-Deficient Megaloblastic Anaemia 12
Folate Deficiency Anemia 12
Folate-Deficiency Anemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14026
ICD10 33 D52 D52.9
ICD9CM 35 281.2
UMLS 73 C0151482

Summaries for Folic Acid Deficiency Anemia

MalaCards based summary : Folic Acid Deficiency Anemia, also known as megaloblastic anemia due to folate deficiency, is related to deficiency anemia and splenic disease. An important gene associated with Folic Acid Deficiency Anemia is SLC46A1 (Solute Carrier Family 46 Member 1), and among its related pathways/superpathways are Insulin receptor recycling and Folate Metabolism. Related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Folic Acid Deficiency Anemia

Diseases related to Folic Acid Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 51)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 27.4 CRP EPO TF TFRC THPO
2 splenic disease 10.4 EPO THPO
3 hypersplenism 10.4 EPO THPO
4 fetal erythroblastosis 10.4 EPO TFRC
5 chromosome 5q deletion syndrome 10.3 EPO TET2
6 erythrocytosis, familial, 1 10.3 EPO THPO
7 refractory anemia 10.3 EPO TET2
8 pure red-cell aplasia 10.3 EPO TF
9 angiomatous meningioma 10.2 TF TFRC
10 hemoglobinopathy 10.1 EPO TF
11 metal metabolism disorder 10.1 TF TFRC
12 siderosis 10.1 TF TFRC
13 pancytopenia 10.1 EPO THPO
14 galactosemia 10.1 GIF TF
15 anemia, sideroblastic, 1 10.1 TET2 TFRC
16 angioimmunoblastic t-cell lymphoma 10.0 MME TET2
17 congenital hemolytic anemia 10.0 EPO TF
18 vitamin b12 deficiency 10.0 EPO GIF TF
19 polycythemia vera 9.9 EPO TET2 THPO
20 bone marrow cancer 9.9 EPO TET2 THPO
21 iron metabolism disease 9.8 EPO TF TFRC
22 hemosiderosis 9.8 EPO TF TFRC
23 essential thrombocythemia 9.8 EPO TET2 THPO
24 hemoglobin h disease 9.8 EPO TF TFRC
25 microcytic anemia 9.8 EPO TF TFRC
26 myelofibrosis 9.8 EPO TET2 THPO
27 thalassemia 9.8 EPO TF TFRC
28 beta-thalassemia 9.8 EPO TF TFRC
29 melancholia 9.8 CRP TF
30 cartilage disease 9.8 CRP TET2
31 perinatal necrotizing enterocolitis 9.8 CRP THPO
32 aplastic anemia 9.8 EPO TET2 THPO
33 dysentery 9.7 CRP TF
34 atransferrinemia 9.7 TET2 TF TFRC
35 porphyria cutanea tarda 9.7 TF TFRC
36 hematologic cancer 9.5 MME TET2 THPO
37 analbuminemia 9.4 CRP EPO TF
38 end stage renal failure 9.4 CRP EPO TF
39 uremia 9.4 CRP EPO TF
40 urinary system disease 9.4 CRP EPO TF
41 polycythemia 9.4 EPO TET2 TFRC THPO
42 chronic kidney failure 9.4 CRP EPO TF
43 inherited metabolic disorder 9.3 CRP TF
44 leukemia, acute myeloid 9.3 MME TET2 THPO
45 purpura 9.1 CRP THPO
46 kidney disease 9.1 CRP EPO TF
47 thrombocytosis 8.9 CRP EPO TET2 THPO
48 myelodysplastic syndrome 8.8 EPO TET2 TF TFRC THPO
49 nutritional deficiency disease 8.5 CRP EPO GIF TF TFRC
50 iron deficiency anemia 8.4 CRP EPO TF TFRC THPO

Comorbidity relations with Folic Acid Deficiency Anemia via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Decubitus Ulcer
Deficiency Anemia Heart Disease
Iron Deficiency Anemia Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Folic Acid Deficiency Anemia:



Diseases related to Folic Acid Deficiency Anemia

Symptoms & Phenotypes for Folic Acid Deficiency Anemia

MGI Mouse Phenotypes related to Folic Acid Deficiency Anemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 SLC46A1 TET2 TF TFRC THPO EPO
2 homeostasis/metabolism MP:0005376 9.76 SLC46A1 TF TFRC THPO CRP EPO
3 immune system MP:0005387 9.56 SLC46A1 TET2 TFRC THPO CRP EPO
4 liver/biliary system MP:0005370 9.02 TET2 TFRC EPO GIF MME

Drugs & Therapeutics for Folic Acid Deficiency Anemia

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Natural Versus Synthetic Vitamin B Complexes in Human Completed NCT03444155 Not Applicable

Search NIH Clinical Center for Folic Acid Deficiency Anemia

Genetic Tests for Folic Acid Deficiency Anemia

Anatomical Context for Folic Acid Deficiency Anemia

Publications for Folic Acid Deficiency Anemia

Articles related to Folic Acid Deficiency Anemia:

# Title Authors Year
1
Folic acid deficiency anemia. ( 4905911 )
1970

Variations for Folic Acid Deficiency Anemia

Expression for Folic Acid Deficiency Anemia

Search GEO for disease gene expression data for Folic Acid Deficiency Anemia.

Pathways for Folic Acid Deficiency Anemia

GO Terms for Folic Acid Deficiency Anemia

Cellular components related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CRP EPO GIF TF TFRC THPO
2 apical plasma membrane GO:0016324 9.54 GIF SLC46A1 TF
3 cell surface GO:0009986 9.46 EPO SLC46A1 TF TFRC
4 extracellular space GO:0005615 9.43 CRP EPO GIF TF TFRC THPO
5 clathrin-coated pit GO:0005905 9.4 TF TFRC
6 clathrin-coated vesicle membrane GO:0030665 9.32 TF TFRC
7 HFE-transferrin receptor complex GO:1990712 8.62 TF TFRC

Biological processes related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 9.26 CRP EPO
2 transferrin transport GO:0033572 9.16 TF TFRC
3 myeloid cell differentiation GO:0030099 8.96 TET2 THPO
4 cellular iron ion homeostasis GO:0006879 8.8 SLC46A1 TF TFRC

Molecular functions related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ferrous iron binding GO:0008198 8.62 TET2 TF

Sources for Folic Acid Deficiency Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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