MCID: FLC001
MIFTS: 32

Folic Acid Deficiency Anemia

Categories: Blood diseases, Immune diseases, Metabolic diseases

Aliases & Classifications for Folic Acid Deficiency Anemia

MalaCards integrated aliases for Folic Acid Deficiency Anemia:

Name: Folic Acid Deficiency Anemia 12 15
Megaloblastic Anemia Due to Folate Deficiency 74
Folate-Deficient Megaloblastic Anaemia 12
Folate Deficiency Anemia 12
Folate-Deficiency Anemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14026
ICD9CM 36 281.2
SNOMED-CT 69 85649008
ICD10 34 D52 D52.9
UMLS 74 C0151482

Summaries for Folic Acid Deficiency Anemia

Disease Ontology : 12 A nutritional deficiency disease that is characterized by a decrease in red blood cells due to lack of folate, has_material_basis in insufficient folic acid in diet, hemolytic anemia, alcoholism, and/or certain medicines.

MalaCards based summary : Folic Acid Deficiency Anemia, also known as megaloblastic anemia due to folate deficiency, is related to deficiency anemia and splenic disease. An important gene associated with Folic Acid Deficiency Anemia is SLC46A1 (Solute Carrier Family 46 Member 1), and among its related pathways/superpathways are Selenium Micronutrient Network and Visual Cycle in Retinal Rods. The drugs Hydroxocobalamin and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include heart, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Folic Acid Deficiency Anemia

Diseases related to Folic Acid Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 30)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 29.0 CRP EPO TFRC THPO
2 splenic disease 10.2 EPO THPO
3 hypersplenism 10.2 EPO THPO
4 erythrocytosis, familial, 1 10.1 EPO THPO
5 fetal erythroblastosis 10.1 EPO TFRC
6 iron metabolism disease 10.1 EPO TFRC
7 hemosiderosis 10.1 EPO TFRC
8 pancytopenia 10.1 EPO THPO
9 hemoglobin h disease 10.1 EPO TFRC
10 microcytic anemia 10.1 EPO TFRC
11 alpha-thalassemia 10.0 EPO TFRC
12 thalassemia 10.0 EPO TFRC
13 beta-thalassemia 10.0 EPO TFRC
14 analbuminemia 9.9 CRP EPO
15 perinatal necrotizing enterocolitis 9.9 CRP THPO
16 nutritional deficiency disease 9.9 CRP EPO
17 intestinal disease 9.9
18 end stage renal failure 9.9 CRP EPO
19 polycythemia 9.9 EPO TFRC THPO
20 uremia 9.9 CRP EPO
21 hemorrhagic fever with renal syndrome 9.9 CRP TFRC
22 urinary system disease 9.8 CRP EPO
23 purpura 9.8 CRP THPO
24 myelodysplastic syndrome 9.8 EPO TFRC THPO
25 congestive heart failure 9.8 EPO MME
26 polycythemia vera 9.8 EPO THPO
27 thrombocytosis 9.7 CRP EPO THPO
28 myeloma, multiple 9.6 CRP EPO MME
29 malaria 9.4 CRP EPO TFRC
30 iron deficiency anemia 9.4 CRP EPO TFRC THPO

Comorbidity relations with Folic Acid Deficiency Anemia via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Decubitus Ulcer
Deficiency Anemia Heart Disease
Iron Deficiency Anemia Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Folic Acid Deficiency Anemia:



Diseases related to Folic Acid Deficiency Anemia

Symptoms & Phenotypes for Folic Acid Deficiency Anemia

MGI Mouse Phenotypes related to Folic Acid Deficiency Anemia:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.7 CBLIF CRP EPO MME SLC46A1 TFRC
2 immune system MP:0005387 9.5 CBLIF CRP EPO MME SLC46A1 TFRC
3 liver/biliary system MP:0005370 8.92 CBLIF EPO MME TFRC

Drugs & Therapeutics for Folic Acid Deficiency Anemia

Drugs for Folic Acid Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxocobalamin Approved Not Applicable 13422-51-0 15589840 11953898
2
leucovorin Approved Not Applicable 58-05-9 143 6006
3
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
4
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
5
Cobalamin Experimental Not Applicable 13408-78-1 6857388
6 Vitamins Not Applicable
7 Vitamin B12 Not Applicable
8 Vitamin B Complex Not Applicable
9 Folate Not Applicable
10 Trace Elements Not Applicable
11 Micronutrients Not Applicable
12 Nutrients Not Applicable
13 Vitamin B 12 Not Applicable
14 Vitamin B9 Not Applicable
15 Hematinics Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Natural Versus Synthetic Vitamin B Complexes in Human Completed NCT03444155 Not Applicable

Search NIH Clinical Center for Folic Acid Deficiency Anemia

Genetic Tests for Folic Acid Deficiency Anemia

Anatomical Context for Folic Acid Deficiency Anemia

MalaCards organs/tissues related to Folic Acid Deficiency Anemia:

42
Heart

Publications for Folic Acid Deficiency Anemia

Articles related to Folic Acid Deficiency Anemia:

# Title Authors Year
1
Folic acid deficiency anemia. ( 4905911 )
1970
2
Infants of mothers with megaloblastic anemia due to folate deficiency. ( 5467155 )
1970

Variations for Folic Acid Deficiency Anemia

Expression for Folic Acid Deficiency Anemia

Search GEO for disease gene expression data for Folic Acid Deficiency Anemia.

Pathways for Folic Acid Deficiency Anemia

GO Terms for Folic Acid Deficiency Anemia

Cellular components related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.35 CBLIF CRP EPO TFRC THPO
2 cell surface GO:0009986 9.33 EPO SLC46A1 TFRC
3 extracellular space GO:0005615 9.02 CBLIF CRP EPO TFRC THPO

Biological processes related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular iron ion homeostasis GO:0006879 8.96 SLC46A1 TFRC
2 acute-phase response GO:0006953 8.62 CRP EPO

Molecular functions related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.62 EPO THPO

Sources for Folic Acid Deficiency Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....