MCID: FLC001
MIFTS: 31

Folic Acid Deficiency Anemia

Categories: Blood diseases, Immune diseases, Metabolic diseases

Aliases & Classifications for Folic Acid Deficiency Anemia

MalaCards integrated aliases for Folic Acid Deficiency Anemia:

Name: Folic Acid Deficiency Anemia 12 15
Megaloblastic Anemia Due to Folate Deficiency 73
Folate-Deficient Megaloblastic Anaemia 12
Folate Deficiency Anemia 12
Folate-Deficiency Anemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14026
ICD10 33 D52 D52.9
ICD9CM 35 281.2
SNOMED-CT 68 85649008
UMLS 73 C0151482

Summaries for Folic Acid Deficiency Anemia

MalaCards based summary : Folic Acid Deficiency Anemia, also known as megaloblastic anemia due to folate deficiency, is related to deficiency anemia and splenic disease. An important gene associated with Folic Acid Deficiency Anemia is SLC46A1 (Solute Carrier Family 46 Member 1), and among its related pathways/superpathways are Insulin receptor recycling and Selenium Micronutrient Network. The drugs Hydroxocobalamin and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include bone, kidney and t cells, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Folic Acid Deficiency Anemia

Diseases related to Folic Acid Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 29.2 CRP EPO TF TFRC THPO
2 splenic disease 10.2 EPO THPO
3 hypersplenism 10.2 EPO THPO
4 fetal erythroblastosis 10.2 EPO TFRC
5 chromosome 5q deletion syndrome 10.2 EPO TET2
6 refractory anemia 10.1 EPO TET2
7 erythrocytosis, familial, 1 10.1 EPO THPO
8 primary polycythemia 10.1 EPO TET2
9 pancytopenia 10.1 EPO THPO
10 anemia, sideroblastic, 1 10.1 TET2 TFRC
11 cartilage disease 10.0 CRP TET2
12 angioimmunoblastic t-cell lymphoma 10.0 MME TET2
13 perinatal necrotizing enterocolitis 10.0 CRP THPO
14 orbital cellulitis 10.0 CRP TET2
15 polycythemia vera 10.0 EPO TET2 THPO
16 bone marrow cancer 10.0 EPO TET2 THPO
17 acquired polycythemia 10.0 EPO TF
18 acute orbital inflammation 10.0 CRP TET2
19 essential thrombocythemia 10.0 EPO TET2 THPO
20 myelofibrosis 10.0 EPO TET2 THPO
21 siderosis 10.0 TF TFRC
22 plethora of newborn 10.0 EPO TF
23 hemorrhagic fever with renal syndrome 10.0 CRP TFRC
24 pure red-cell aplasia 10.0 EPO TF
25 vitamin b12 deficiency 10.0 EPO TF
26 aplastic anemia 10.0 EPO TET2 THPO
27 angiomatous meningioma 10.0 TF TFRC
28 iron overload in africa 10.0 TF TFRC
29 metal metabolism disorder 9.9 TF TFRC
30 hemoglobinopathy 9.9 EPO TF
31 peripheral t-cell lymphoma 9.9 MME TET2
32 congenital hemolytic anemia 9.9 EPO TF
33 hematologic cancer 9.9 MME TET2 THPO
34 melancholia 9.9 CRP TF
35 purpura 9.9 CRP THPO
36 myeloma, multiple 9.9 CRP EPO MME
37 intestinal disease 9.9
38 hemosiderosis 9.9 EPO TF TFRC
39 polycythemia 9.9 EPO TET2 TFRC THPO
40 porphyria cutanea tarda 9.9 TF TFRC
41 iron metabolism disease 9.9 EPO TF TFRC
42 dysentery 9.9 CRP TF
43 hemoglobin h disease 9.9 EPO TF TFRC
44 microcytic anemia 9.9 EPO TF TFRC
45 thalassemia 9.9 EPO TF TFRC
46 beta-thalassemia 9.9 EPO TF TFRC
47 leukemia, acute myeloid 9.9 MME TET2 THPO
48 atransferrinemia 9.8 TET2 TF TFRC
49 thrombocytosis 9.8 CRP EPO TET2 THPO
50 analbuminemia 9.8 CRP EPO TF

Comorbidity relations with Folic Acid Deficiency Anemia via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Decubitus Ulcer
Deficiency Anemia Heart Disease
Iron Deficiency Anemia Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Folic Acid Deficiency Anemia:



Diseases related to Folic Acid Deficiency Anemia

Symptoms & Phenotypes for Folic Acid Deficiency Anemia

MGI Mouse Phenotypes related to Folic Acid Deficiency Anemia:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.8 CBLIF EPO SLC46A1 TET2 TF TFRC
2 homeostasis/metabolism MP:0005376 9.76 CBLIF CRP EPO MME SLC46A1 TF
3 immune system MP:0005387 9.56 CBLIF CRP EPO MME SLC46A1 TET2
4 liver/biliary system MP:0005370 9.02 CBLIF EPO MME TET2 TFRC

Drugs & Therapeutics for Folic Acid Deficiency Anemia

Drugs for Folic Acid Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Hydroxocobalamin Approved Not Applicable 13422-51-0 11953898 44475014
2
leucovorin Approved Not Applicable 58-05-9 6006 143
3
Cyanocobalamin Approved, Nutraceutical Not Applicable 68-19-9 44176380
4
Folic Acid Approved, Nutraceutical, Vet_approved Not Applicable 59-30-3 6037
5
Cobalamin Experimental Not Applicable 13408-78-1 6438156
6 Vitamin B Complex Not Applicable
7 Trace Elements Not Applicable
8 Vitamin B9 Not Applicable
9 Micronutrients Not Applicable
10 Hematinics Not Applicable
11 Folate Not Applicable
12 Vitamins Not Applicable
13 Vitamin B12 Not Applicable
14 Vitamin B 12 Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Natural Versus Synthetic Vitamin B Complexes in Human Completed NCT03444155 Not Applicable

Search NIH Clinical Center for Folic Acid Deficiency Anemia

Genetic Tests for Folic Acid Deficiency Anemia

Anatomical Context for Folic Acid Deficiency Anemia

MalaCards organs/tissues related to Folic Acid Deficiency Anemia:

41
Bone, Kidney, T Cells, Myeloid, Bone Marrow

Publications for Folic Acid Deficiency Anemia

Articles related to Folic Acid Deficiency Anemia:

# Title Authors Year
1
Folic acid deficiency anemia. ( 4905911 )
1970

Variations for Folic Acid Deficiency Anemia

Expression for Folic Acid Deficiency Anemia

Search GEO for disease gene expression data for Folic Acid Deficiency Anemia.

Pathways for Folic Acid Deficiency Anemia

GO Terms for Folic Acid Deficiency Anemia

Cellular components related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CBLIF CRP EPO TF TFRC THPO
2 apical plasma membrane GO:0016324 9.54 CBLIF SLC46A1 TF
3 cell surface GO:0009986 9.46 EPO SLC46A1 TF TFRC
4 extracellular space GO:0005615 9.43 CBLIF CRP EPO TF TFRC THPO
5 clathrin-coated pit GO:0005905 9.4 TF TFRC
6 clathrin-coated vesicle membrane GO:0030665 9.32 TF TFRC
7 HFE-transferrin receptor complex GO:1990712 8.62 TF TFRC

Biological processes related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 9.26 CRP EPO
2 transferrin transport GO:0033572 9.16 TF TFRC
3 myeloid cell differentiation GO:0030099 8.96 TET2 THPO
4 cellular iron ion homeostasis GO:0006879 8.8 SLC46A1 TF TFRC

Molecular functions related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ferrous iron binding GO:0008198 8.62 TET2 TF

Sources for Folic Acid Deficiency Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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