MCID: FLC001
MIFTS: 30

Folic Acid Deficiency Anemia

Categories: Blood diseases, Immune diseases, Metabolic diseases

Aliases & Classifications for Folic Acid Deficiency Anemia

MalaCards integrated aliases for Folic Acid Deficiency Anemia:

Name: Folic Acid Deficiency Anemia 12 15
Folate Deficiency Anaemia 12 32
Megaloblastic Anemia Due to Folate Deficiency 70
Folate-Deficient Megaloblastic Anaemia 12
Folic Acid Deficiency Anaemia 12
Folate-Deficiency Anaemia 12
Folate Deficiency Anemia 12
Folate-Deficiency Anemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14026
ICD9CM 34 281.2
SNOMED-CT 67 85649008
ICD10 32 D52 D52.9
UMLS 70 C0151482

Summaries for Folic Acid Deficiency Anemia

Disease Ontology : 12 A nutritional deficiency disease that is characterized by a decrease in red blood cells due to lack of folate, has material basis in insufficient folic acid in diet, hemolytic anemia, alcoholism, and/or certain medicines.

MalaCards based summary : Folic Acid Deficiency Anemia, also known as folate deficiency anaemia, is related to folate malabsorption, hereditary and hemochromatosis, type 1. An important gene associated with Folic Acid Deficiency Anemia is SLC46A1 (Solute Carrier Family 46 Member 1), and among its related pathways/superpathways are Selenium Micronutrient Network and HIF-1-alpha transcription factor network. Affiliated tissues include brain, colon and kidney.

Related Diseases for Folic Acid Deficiency Anemia

Diseases related to Folic Acid Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 folate malabsorption, hereditary 30.5 SLC46A1 FOLR3
2 hemochromatosis, type 1 29.8 TFRC SLC46A1 HAMP EPO
3 deficiency anemia 29.3 TFRC SLC46A1 HAMP EPO CYGB CRP
4 megaloblastic anemia due to dihydrofolate reductase deficiency 10.3
5 constitutional megaloblastic anemia due to folate metabolism disorder 10.3
6 lung clear cell carcinoma 10.2 HAMP EPO
7 anemia of prematurity 10.2 HAMP EPO
8 vitamin metabolic disorder 10.2 SLC46A1 EPO
9 epidermolysis bullosa simplex, ogna type 10.2 EPO CRP
10 viral exanthem 10.1 EPO CRP
11 miliary tuberculosis 10.1 EPO CRP
12 asphyxia neonatorum 10.1 EPO CRP
13 hemosiderosis 10.1 HAMP EPO
14 iritis 10.1 EPO CRP
15 analbuminemia 10.1 EPO CRP
16 erythrocytosis, familial, 2 10.1 HAMP EPO
17 encephalomalacia 10.1 EPO CRP
18 multicentric castleman disease 10.1 HAMP CRP
19 extrapulmonary tuberculosis 10.1 HAMP CRP
20 congenital hemolytic anemia 10.0 HAMP EPO
21 pulmonary edema 10.0 EPO CRP
22 mineral metabolism disease 10.0 HAMP CRP
23 atransferrinemia 10.0 TFRC HAMP
24 hemochromatosis, type 3 10.0 TFRC HAMP
25 hypochromic microcytic anemia 10.0 TFRC HAMP
26 hemochromatosis, type 4 10.0 TFRC HAMP
27 sleep apnea 10.0 EPO CRP
28 siderosis 10.0 TFRC HAMP
29 acne 10.0
30 hemochromatosis type 2 10.0 TFRC HAMP
31 epiglottis cancer 10.0 EPO CYGB
32 metal metabolism disorder 10.0 TFRC HAMP
33 thrombocytosis 9.9 EPO CRP
34 splenic sequestration 9.9 EPO CYGB
35 pancytopenia 9.9
36 intestinal disease 9.9
37 placental abruption 9.9
38 epidural abscess 9.9 CYGB CRP
39 benign essential hypertension 9.9 CYGB CRP
40 large intestine lipoma 9.9 CYGB CRP
41 lipoma of colon 9.9 CYGB CRP
42 parasitic protozoa infectious disease 9.9 TFRC CRP
43 uremia 9.9 EPO CRP
44 aceruloplasminemia 9.9 TFRC SLC46A1 HAMP
45 polycythemia 9.9 TFRC HAMP EPO
46 anemia, congenital dyserythropoietic, type ia 9.9 TFRC HAMP EPO
47 microcytic anemia 9.9 TFRC HAMP EPO
48 congenital dyserythropoietic anemia 9.9 TFRC HAMP EPO
49 hemoglobin h disease 9.8 TFRC HAMP EPO
50 porphyria cutanea tarda 9.8 TFRC HAMP EPO

Comorbidity relations with Folic Acid Deficiency Anemia via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Decubitus Ulcer
Deficiency Anemia Heart Disease
Iron Deficiency Anemia Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Folic Acid Deficiency Anemia:



Diseases related to Folic Acid Deficiency Anemia

Symptoms & Phenotypes for Folic Acid Deficiency Anemia

Drugs & Therapeutics for Folic Acid Deficiency Anemia

Search Clinical Trials , NIH Clinical Center for Folic Acid Deficiency Anemia

Genetic Tests for Folic Acid Deficiency Anemia

Anatomical Context for Folic Acid Deficiency Anemia

MalaCards organs/tissues related to Folic Acid Deficiency Anemia:

40
Brain, Colon, Kidney, Lung

Publications for Folic Acid Deficiency Anemia

Articles related to Folic Acid Deficiency Anemia:

(show all 27)
# Title Authors PMID Year
1
Safety and benefits of interventions to increase folate status in malaria-endemic areas. 61
28369746 2017
2
Prevalence of anemia and malnutrition and their association in elderly nursing home residents. 61
26572155 2016
3
The prevalence of anemia, iron, vitamin B12, and folic acid deficiencies in community dwelling elderly in Ankara, Turkey. 61
25616321 2015
4
Prevalence and incidence of anemia in the German Heinz Nixdorf Recall Study. 61
23430088 2013
5
[Importance of infant feeding during the first year of life]. 61
22352125 2011
6
Severe folate-deficiency pancytopenia. 61
22791479 2010
7
Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers. 61
17341272 2007
8
Vitamin B12 and folate deficiency anaemia associated with isotretinoin treatment for acne. 61
16716177 2006
9
Nutritional deficiency in Dutch primary care: data from general practice research and registration networks. 61
16052190 2005
10
Long-term erythropoietin therapy improves response in myelodysplastic syndrome. 61
16076383 2005
11
Thrombotic thrombocytopenic purpura due to alcohol binge drinking. 61
15288684 2004
12
[B12-folic-acid-deficiency anemia in a patient occurring as a result of exposure to ionizing radiation]. 61
1792789 1991
13
Serum folate levels in normal full-term pregnant Chinese women. 61
3218460 1988
14
Haematological laboratory findings in the elderly: influence of age and sex. 61
3749786 1986
15
[Errors in the diagnosis of B12- and folic acid-deficiency anemia]. 61
3787485 1986
16
[Folic acid deficiency anemia caused by therapy in chronic renal insufficiency]. 61
2414185 1985
17
Consequences of ileal dysfunction: an approach to management. 61
104134 1978
18
[Level of red blood cell phosphorilated compounds in nutritional anemias (author's transl)]. 61
1243953 1975
19
The effect of iron and folic acid therapy on combined iron and folate deficiency anaemia: the results of a clinical trial. 61
4587790 1973
20
[Folic acid deficiency anemia due to oral contraceptives]. 61
4645057 1972
21
[Folic acid deficiency anemia following long-term use of oral contraceptives]. 61
5141585 1971
22
Vitamin B 12 levels in erythrocytes in hypochromic anaemia. 61
5130536 1971
23
[Folic acid deficiency anemia]. 61
5530036 1970
24
Folic acid deficiency anemia. 61
4905911 1970
25
[NUTRITIONAL FOLIC ACID DEFICIENCY ANEMIA. STUDIES WITH H3-LABELLED FOLIC ACID, CO58-LABELLED VITAMIN B12, FE59- AND H3-LABELLED THYMIDIN]. 61
14305758 1965
26
[MEGALOBLASTIC FOLIC ACID DEFICIENCY ANEMIA IN HEMOCHROMATOSIS]. 61
14117076 1964
27
[MEGALOBLASTIC FOLIC ACID DEFICIENCY ANEMIA IN HEMOCHROMATOSIS]. 61
14093394 1963

Variations for Folic Acid Deficiency Anemia

Expression for Folic Acid Deficiency Anemia

Search GEO for disease gene expression data for Folic Acid Deficiency Anemia.

Pathways for Folic Acid Deficiency Anemia

Pathways related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.47 SLC46A1 FOLR3 CRP
2 11.07 TFRC EPO
3 10.65 SLC46A1 FOLR3
4 9.7 TFRC HAMP

GO Terms for Folic Acid Deficiency Anemia

Cellular components related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.1 TFRC HAMP FOLR3 EPO CRP ADGRE3

Biological processes related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to vitamin A GO:0033189 9.26 HAMP EPO
2 folic acid transport GO:0015884 9.16 SLC46A1 FOLR3
3 cellular iron ion homeostasis GO:0006879 9.13 TFRC SLC46A1 HAMP
4 acute-phase response GO:0006953 8.8 HAMP EPO CRP

Molecular functions related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 folic acid binding GO:0005542 8.62 SLC46A1 FOLR3

Sources for Folic Acid Deficiency Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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