MCID: FLC001
MIFTS: 29

Folic Acid Deficiency Anemia

Categories: Blood diseases, Immune diseases, Metabolic diseases

Aliases & Classifications for Folic Acid Deficiency Anemia

MalaCards integrated aliases for Folic Acid Deficiency Anemia:

Name: Folic Acid Deficiency Anemia 12 15
Megaloblastic Anemia Due to Folate Deficiency 71
Folate-Deficient Megaloblastic Anaemia 12
Folate Deficiency Anemia 12
Folate-Deficiency Anemia 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14026
ICD9CM 34 281.2
SNOMED-CT 67 85649008
ICD10 32 D52 D52.9
UMLS 71 C0151482

Summaries for Folic Acid Deficiency Anemia

Disease Ontology : 12 A nutritional deficiency disease that is characterized by a decrease in red blood cells due to lack of folate, has material basis in insufficient folic acid in diet, hemolytic anemia, alcoholism, and/or certain medicines.

MalaCards based summary : Folic Acid Deficiency Anemia, also known as megaloblastic anemia due to folate deficiency, is related to deficiency anemia and megaloblastic anemia. An important gene associated with Folic Acid Deficiency Anemia is SLC46A1 (Solute Carrier Family 46 Member 1), and among its related pathways/superpathways are Folate Metabolism and Vitamin digestion and absorption. The drugs Methylcobalamin and leucovorin have been mentioned in the context of this disorder. Affiliated tissues include liver, and related phenotype is immune system.

Related Diseases for Folic Acid Deficiency Anemia

Diseases related to Folic Acid Deficiency Anemia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 37)
# Related Disease Score Top Affiliating Genes
1 deficiency anemia 29.9 SLC46A1 EPO CRP CBLIF
2 megaloblastic anemia 29.9 SLC46A1 CBLIF
3 pancytopenia 29.4 EPO CRP CBLIF
4 hemochromatosis, type 1 10.1
5 vitamin b12 deficiency 10.1 EPO CBLIF
6 renal artery disease 10.0 EPO CRP
7 iritis 10.0 EPO CRP
8 gastroduodenal crohn's disease 10.0 CRP CBLIF
9 miliary tuberculosis 10.0 EPO CRP
10 viral esophagitis 10.0 CRP CBLIF
11 asphyxia neonatorum 10.0 EPO CRP
12 pernicious anemia 10.0
13 macrocytic anemia 10.0
14 liver cirrhosis 10.0
15 hypersplenism 10.0
16 analbuminemia 10.0 EPO CRP
17 encephalomalacia 10.0 EPO CRP
18 iron metabolism disease 9.9 EPO CRP
19 iron deficiency anemia 9.9 EPO CRP
20 intestinal disease 9.9
21 placental abruption 9.9
22 blood coagulation disease 9.9 EPO CRP
23 exudative vitreoretinopathy 1 9.9 EPO CRP
24 pulmonary edema 9.8 EPO CRP
25 thrombocytosis 9.8 EPO CRP
26 autoimmune disease of gastrointestinal tract 9.7 TOR1A CBLIF
27 sleep apnea 9.7 EPO CRP
28 vitamin metabolic disorder 9.7 EPO CRP CBLIF
29 nutritional deficiency disease 9.7 EPO CRP CBLIF
30 duodenitis 9.7 TOR1A CRP
31 whipple disease 9.7 TOR1A CRP
32 uremia 9.7 EPO CRP
33 lactose intolerance 9.6 TOR1A CRP
34 tropical sprue 9.6 TOR1A SLC46A1 CBLIF
35 cellulitis 9.6 TOR1A CRP
36 peripheral vascular disease 9.5 EPO CRP
37 celiac disease 1 9.3 TOR1A CRP CBLIF

Comorbidity relations with Folic Acid Deficiency Anemia via Phenotypic Disease Network (PDN):


Active Peptic Ulcer Disease Acute Cystitis
Alzheimer Disease Decubitus Ulcer
Deficiency Anemia Heart Disease
Iron Deficiency Anemia Protein-Energy Malnutrition
Schizophreniform Disorder

Graphical network of the top 20 diseases related to Folic Acid Deficiency Anemia:



Diseases related to Folic Acid Deficiency Anemia

Symptoms & Phenotypes for Folic Acid Deficiency Anemia

MGI Mouse Phenotypes related to Folic Acid Deficiency Anemia:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.1 ATP5MD CBLIF CRP EPO LDLRAD4 SLC46A1

Drugs & Therapeutics for Folic Acid Deficiency Anemia

Drugs for Folic Acid Deficiency Anemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methylcobalamin Approved, Investigational 13422-55-4
2
leucovorin Approved 58-05-9 6006 143
3
Hydroxocobalamin Approved 13422-51-0 11953898 15589840
4
Folic acid Approved, Nutraceutical, Vet_approved 59-30-3 6037
5
Cyanocobalamin Approved, Nutraceutical 68-19-9 44176380
6
Cobalamin Experimental 13408-78-1 6857388
7 Vitamins
8 Vitamin B 12
9 Vitamin B Complex
10 Vitamin B9
11 Vitamin B12
12 Folate

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Periconceptional Surveillance for Prevention of Anemia and Birth Defects in India Recruiting NCT04048330

Search NIH Clinical Center for Folic Acid Deficiency Anemia

Genetic Tests for Folic Acid Deficiency Anemia

Anatomical Context for Folic Acid Deficiency Anemia

MalaCards organs/tissues related to Folic Acid Deficiency Anemia:

40
Liver

Publications for Folic Acid Deficiency Anemia

Articles related to Folic Acid Deficiency Anemia:

(show all 27)
# Title Authors PMID Year
1
Prevalence of anemia and malnutrition and their association in elderly nursing home residents. 61
26572155 2016
2
The prevalence of anemia, iron, vitamin B12, and folic acid deficiencies in community dwelling elderly in Ankara, Turkey. 61
25616321 2015
3
Prevalence and incidence of anemia in the German Heinz Nixdorf Recall Study. 61
23430088 2013
4
[Importance of infant feeding during the first year of life]. 61
22352125 2011
5
Long-term erythropoietin therapy improves response in myelodysplastic syndrome. 61
16076383 2005
6
Thrombotic thrombocytopenic purpura due to alcohol binge drinking. 61
15288684 2004
7
Current status of nutritional deficiencies in Canadian aboriginal people. 61
7585349 1995
8
[Megaloblastic anemia due to folate deficiency associated with hereditary spherocytosis]. 61
8028187 1994
9
Megaloblastic anemia associated with psoriasis: case report and review of the literature. 61
1568032 1992
10
[B12-folic-acid-deficiency anemia in a patient occurring as a result of exposure to ionizing radiation]. 61
1792789 1991
11
Serum folate levels in normal full-term pregnant Chinese women. 61
3218460 1988
12
[Megaloblastic anemia due to folate deficiency--including a case complicated by intravenous hyperalimentation or tube feeding]. 61
3086599 1986
13
[Errors in the diagnosis of B12- and folic acid-deficiency anemia]. 61
3787485 1986
14
[Folic acid deficiency anemia caused by therapy in chronic renal insufficiency]. 61
2414185 1985
15
Nutritional anemia in alcoholism. 61
7001890 1980
16
Effects of alcohol on granulocytes and lymphocytes. 61
7375952 1980
17
Plasma cells with inclusions containing iron. 61
226026 1979
18
[Level of red blood cell phosphorilated compounds in nutritional anemias (author's transl)]. 61
1243953 1975
19
Depressed cell-mediated immunity in megaloblastic anemia due to folic acid deficiency. 61
1119420 1975
20
[Folic acid deficiency anemia due to oral contraceptives]. 61
4645057 1972
21
[Folic acid deficiency anemia following long-term use of oral contraceptives]. 61
5141585 1971
22
[Folic acid deficiency anemia]. 61
5530036 1970
23
Infants of mothers with megaloblastic anemia due to folate deficiency. 61
5467155 1970
24
Folic acid deficiency anemia. 61
4905911 1970
25
[NUTRITIONAL FOLIC ACID DEFICIENCY ANEMIA. STUDIES WITH H3-LABELLED FOLIC ACID, CO58-LABELLED VITAMIN B12, FE59- AND H3-LABELLED THYMIDIN]. 61
14305758 1965
26
[MEGALOBLASTIC FOLIC ACID DEFICIENCY ANEMIA IN HEMOCHROMATOSIS]. 61
14117076 1964
27
[MEGALOBLASTIC FOLIC ACID DEFICIENCY ANEMIA IN HEMOCHROMATOSIS]. 61
14093394 1963

Variations for Folic Acid Deficiency Anemia

Expression for Folic Acid Deficiency Anemia

Search GEO for disease gene expression data for Folic Acid Deficiency Anemia.

Pathways for Folic Acid Deficiency Anemia

Pathways related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.46 SLC46A1 CRP CBLIF
2 10 SLC46A1 CBLIF

GO Terms for Folic Acid Deficiency Anemia

Biological processes related to Folic Acid Deficiency Anemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 acute-phase response GO:0006953 8.62 EPO CRP

Sources for Folic Acid Deficiency Anemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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