MCID: FLL031
MIFTS: 39

Follicular Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Follicular Adenoma

MalaCards integrated aliases for Follicular Adenoma:

Name: Follicular Adenoma 12 15 73
Follicular Adenoma of the Thyroid Gland 12
Thyroid Gland Follicular Adenoma 73
Thyroid Follicular Adenoma 12
Adenoma Follicular 55

Classifications:



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Disease Ontology 12 DOID:6204
MeSH 44 D000236
SNOMED-CT 68 55021007

Summaries for Follicular Adenoma

MalaCards based summary : Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to atypical follicular adenoma and primary hyperparathyroidism. An important gene associated with Follicular Adenoma is LGALS3 (Galectin 3), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Human Thyroid Stimulating Hormone (TSH) signaling pathway. The drugs Iodine and Formaldehyde have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and lung, and related phenotypes are Increased shRNA abundance and endocrine/exocrine gland

Related Diseases for Follicular Adenoma

Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 100)
# Related Disease Score Top Affiliating Genes
1 atypical follicular adenoma 33.9 CALCA TG
2 primary hyperparathyroidism 30.0 CALCA CDKN1B RET
3 hyperparathyroidism 30.0 CALCA CDKN1B RET
4 small cell carcinoma 29.8 CALCA NKX2-1 PTEN
5 hemangioma 29.8 NKX2-1 PTEN RET
6 cowden disease 29.7 CALCA PTEN RET TG
7 thyroiditis 29.5 CALCA RET TG TPO TSHR
8 papillary carcinoma 29.3 CALCA KRT19 LGALS3 NKX2-1 PAX8 RET
9 nodular goiter 29.2 CALCA LGALS3 RET TG TPO TSHR
10 goiter 29.0 CALCA LGALS3 NKX2-1 PAX8 SLC26A4 TG
11 differentiated thyroid carcinoma 29.0 NKX2-1 PAX8 RET TG TPO TSHR
12 multinodular goiter 28.6 CALCA NKX2-1 PAX8 SLC26A4 TG TPO
13 thyroid cancer, nonmedullary, 2 28.5 CALCA DPP4 KRT19 LGALS3 NKX2-1 PAX8
14 hypothyroidism 28.5 CALCA NKX2-1 PAX8 RET SLC26A4 TG
15 thyroid cancer 28.2 CALCA CDKN1B KRT19 LGALS3 NKX2-1 PAX8
16 oncocytoma 11.2
17 adenoma 10.8
18 thyroid cancer, nonmedullary, 1 10.3
19 subacute lymphocytic thyroiditis 10.3 TG TPO
20 acute thyroiditis 10.3 CALCA TG
21 familial thyroid dyshormonogenesis 10.2 TG TPO
22 mucoepidermoid thyroid carcinoma 10.2 CALCA TG
23 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.2 TG TPO
24 suppurative thyroiditis 10.2 CALCA TG
25 thyroid sarcoma 10.2 CALCA TG
26 plummer's disease 10.2 TG TPO
27 hypoadrenalism 10.2 CALCA TG
28 corneal abscess 10.2 KRT19 PTEN
29 amyloid tumor 10.2 CALCA TG
30 colloid adenoma 10.2 LGALS3 NKX2-1 TG
31 mucinous bronchioloalveolar adenocarcinoma 10.2 LGALS3 NKX2-1
32 premature menopause 10.2 TG TPO
33 ovarian germ cell teratoma 10.2 NKX2-1 RET TG
34 ovarian germ cell cancer 10.2 NKX2-1 RET TG
35 pernicious anemia 10.2 TG TPO
36 parathyroid carcinoma 10.1 CALCA LGALS3 RET
37 dyshormonogenic goiter 10.1 SLC26A4 TG
38 chordoma 10.1 KRT19 LGALS3 PTEN
39 prostate small cell carcinoma 10.1 NKX2-1 PTEN
40 ovarian cystic teratoma 10.1 CALCA NKX2-1 TG
41 polyposis, skin pigmentation, alopecia, and fingernail changes 10.1 KRT19 PTEN
42 respiratory system cancer 10.1 KRT19 NKX2-1 PTEN
43 water-clear cell adenoma 10.1 PAX8 TG
44 renal pelvis adenocarcinoma 10.1 KRT19 PAX8
45 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.1 TG TPO
46 multiple endocrine neoplasia, type iib 10.1 CALCA CDKN1B RET
47 multiple endocrine neoplasia 10.1 CALCA CDKN1B RET
48 celiac disease 1 10.1 DPP4 TG TPO
49 mixed type thymoma 10.1 PAX8 PTEN
50 fetal adenoma 10.1 CALCA LGALS3 NKX2-1 TG

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to Follicular Adenoma

Symptoms & Phenotypes for Follicular Adenoma

GenomeRNAi Phenotypes related to Follicular Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 CALCA CDKN1B LGALS3 MCM2

MGI Mouse Phenotypes related to Follicular Adenoma:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.35 CDKN1B DPP4 KRT19 MCM2 NKX2-1 PAX8
2 growth/size/body region MP:0005378 10.34 CDKN1B DPP4 KRT19 LGALS3 MCM2 NKX2-1
3 cellular MP:0005384 10.26 CDKN1B KRT19 LGALS3 MCM2 NKX2-1 PAX8
4 homeostasis/metabolism MP:0005376 10.26 CDKN1B DPP4 LGALS3 NKX2-1 PAX8 PTEN
5 behavior/neurological MP:0005386 10.22 CDKN1B LGALS3 MCM2 NKX2-1 PAX8 PTEN
6 digestive/alimentary MP:0005381 10.2 CDKN1B KRT19 LGALS3 MCM2 NKX2-1 PTEN
7 immune system MP:0005387 10.16 CDKN1B LGALS3 MCM2 PTEN RET SLC26A4
8 hematopoietic system MP:0005397 10.15 CDKN1B LGALS3 MCM2 PTEN RET TG
9 mortality/aging MP:0010768 10.14 CDKN1B KRT19 LGALS3 MCM2 NKX2-1 PAX8
10 nervous system MP:0003631 10.06 CDKN1B KRT19 LGALS3 MCM2 NKX2-1 PAX8
11 neoplasm MP:0002006 10.02 CDKN1B KRT19 LGALS3 MCM2 NKX2-1 PTEN
12 hearing/vestibular/ear MP:0005377 9.91 CDKN1B PAX8 SLC26A4 TPO TSHR
13 limbs/digits/tail MP:0005371 9.91 PAX8 PTEN RET TG TPO TSHR
14 reproductive system MP:0005389 9.85 CDKN1B KRT19 LGALS3 NKX2-1 PAX8 PTEN
15 renal/urinary system MP:0005367 9.73 CDKN1B LGALS3 PAX8 PTEN RET SLC26A4
16 respiratory system MP:0005388 9.43 CDKN1B LGALS3 MCM2 NKX2-1 PTEN RET
17 skeleton MP:0005390 9.32 CDKN1B KRT19 LGALS3 NKX2-1 PAX8 PTEN

Drugs & Therapeutics for Follicular Adenoma

Drugs for Follicular Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational 7553-56-2 807
2
Formaldehyde Approved, Vet_approved 50-00-0 712
3 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of a New CZT System Unknown status NCT01084356
2 Biomarkers to Distinguish Benign From Malignant Thyroid Neoplasm Completed NCT01433809
3 Molecular Markers in Thyroid Cancer Completed NCT00598364
4 Expression of NIS Protein and mRNA in Thyroid Tumors Completed NCT00459498
5 PACE4 in Thyroid Cancer Completed NCT03160482
6 Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism. Recruiting NCT03091140
7 French Childhood Cancer Survivor Study Recruiting NCT01620372
8 ctDNA in Patients With Thyroid Nodules Terminated NCT02778412

Search NIH Clinical Center for Follicular Adenoma

Genetic Tests for Follicular Adenoma

Anatomical Context for Follicular Adenoma

MalaCards organs/tissues related to Follicular Adenoma:

41
Thyroid, Bone, Lung, Skin, Prostate, Testis, T Cells

Publications for Follicular Adenoma

Articles related to Follicular Adenoma:

(show top 50) (show all 123)
# Title Authors Year
1
Artificial neural network model to distinguish follicular adenoma from follicular carcinoma on fine needle aspiration of thyroid. ( 29266871 )
2018
2
Tumour growth rate of follicular thyroid carcinoma is not different from that of follicular adenoma. ( 29509975 )
2018
3
A six-gene panel to label follicular adenoma, low- and high-risk follicular thyroid carcinoma. ( 29298844 )
2018
4
Carney complex: a case with thyroid follicular adenoma without a PRKAR1A mutation. ( 29666959 )
2018
5
TERT, HRAS, and EIF1AX Mutations in a Patient with Follicular Adenoma. ( 29669480 )
2018
6
Hashimoto's thyroiditis, nodular goiter or follicular adenoma combined with papillary thyroid carcinoma play protective role in patients. ( 29788738 )
2018
7
Encapsulated Follicular Variant of Papillary Thyroid Carcinoma Arising in a Follicular Adenoma: a Diagnostic Dilemma. ( 30288010 )
2018
8
Atypical Features Resembling Poorly Differentiated Thyroid Carcinoma Presenting Entirely within a Follicular Adenoma. ( 30112239 )
2018
9
A rare presentation: A case report of osseous metaplasia and mature bone formation in a follicular adenoma of the thyroid. ( 28648877 )
2017
10
Tumor-to-tumor metastasis: Small cell carcinoma lung metastasising into a follicular adenoma of the thyroid. ( 28195115 )
2017
11
Follicular adenoma in ectopic thyroid. A case-report. ( 28946030 )
2017
12
Can Nodular Hyperplasia of the Thyroid Gland be Differentiated From Follicular Adenoma and Follicular Carcinoma by Ultrasonography? ( 27870787 )
2016
13
Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma. ( 27626165 )
2016
14
Incidental ectopic thyroid follicular adenoma on myocardial perfusion imaging. ( 26122882 )
2016
15
Thyroid follicular adenoma with numerous intracytoplasmic lumina mimicking yellow bodies: a case report. ( 27146719 )
2016
16
Papillary Thyroid Carcinoma Arising Within a Follicular Adenoma: A Case Report, Ultrasound Features, and Considerations. ( 27110655 )
2016
17
Expression of ARE-binding proteins AUF1 and HuR in follicular adenoma and carcinoma of thyroid gland. ( 26925783 )
2016
18
Association between p53-binding protein 1 expression and genomic instability in oncocytic follicular adenoma of the thyroid. ( 26935218 )
2016
19
Appearance of HA1rthle cell carcinoma soon after surgical extirpation of HA1rthle cell adenoma and follicular adenoma of the thyroid gland. ( 25810698 )
2015
20
Not All Post-FNA Spindle Cell Proliferations in the Thyroid Are of Myofibroblastic Origin: Follicular Adenoma with Spindle Cell Metaplasia. ( 26490689 )
2015
21
Determination-of apoptosis and cell cycle modulators (p16, p21, p27, p53, BCL-2, Bax, BCL-xL, and cyclin D1) in thyroid follicular carcinoma, follicular adenoma, and adenomatous nodules via a tissue microarray method. ( 26422859 )
2015
22
Identification of Novel Biomarker and Therapeutic Target Candidates for Diagnosis and Treatment of Follicular Adenoma. ( 26543076 )
2015
23
Risk of thyroid follicular adenoma among children and adolescents in Belarus exposed to iodine-131 after the Chornobyl accident. ( 26443421 )
2015
24
How should a follicular adenoma with papillary architecture be classified on thyroid FNA? Case report with histological correlation. ( 25073478 )
2015
25
Better understanding in the differentiation of thyroid follicular adenoma, follicular carcinoma, and follicular variant of papillary carcinoma: a retrospective study. ( 25309594 )
2014
26
Meningioma like tumour of thyroid: a rare variant of follicular adenoma. ( 24640816 )
2014
27
Sonographic features of thyroid follicular carcinoma in comparison with thyroid follicular adenoma. ( 24449724 )
2014
28
Unusual association of primary hyperparathyroidism, papillary thyroid carcinoma, and follicular adenoma in a young female. ( 23776923 )
2013
29
The unique liquid-based cytologic findings of thyroid signet-ring follicular adenoma: a report of two cases with fine needle aspiration cytology. ( 23220878 )
2013
30
Thyroid Follicular Adenoma with Accumulation of Collagen Type IV in a Common Marmoset (Callithrix jacchus). ( 24060155 )
2013
31
Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer. ( 23751876 )
2013
32
A case of asymptomatic riedel thyroiditis with follicular adenoma in a patient with a multinodular goiter: an unusual association. ( 24783021 )
2012
33
Genetic studies in a coexistence of acromegaly, pheochromocytoma, gastrointestinal stromal tumor (GIST) and thyroid follicular adenoma. ( 23295290 )
2012
34
Follicular adenoma with extensive extracellular mucin deposition: report on two cases. ( 23236259 )
2012
35
Follicular adenoma presenting as lateral aberrant thyroid. ( 21854673 )
2012
36
Value of immunohistochemical expression of p27 and galectin-3 in differentiation between follicular adenoma and follicular carcinoma. ( 22553813 )
2012
37
Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma. ( 22086610 )
2012
38
Fine needle aspiration biopsy of an unusual follicular adenoma with sebaceous-like features. ( 22527948 )
2012
39
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. ( 21623114 )
2011
40
Cytologic features of focal papillary thyroid carcinoma arising within follicular adenoma: a masked cytomorphologic analysis of 17 cases. ( 22156462 )
2011
41
Thyroid follicular adenoma composed of lipid-rich cells. ( 21165779 )
2011
42
Comment on: synchronous occurrence of anaplastic, follicular, and papillary carcinoma with follicular adenoma in thyroid gland. ( 21623130 )
2011
43
Follicular adenoma and carcinoma of the thyroid gland. ( 21482585 )
2011
44
Differential diagnosis of follicular cancer and follicular adenoma using an expert system based on a set of qualitative signs of cell atypia. ( 22611752 )
2011
45
Squamous cell components in a thyroid follicular adenoma: significant evidence of follicular cell origin by histomorphological, immunohistochemical and molecular analyses. ( 21951666 )
2011
46
Comparison of proliferating cell nuclear antigen, thyroid transcription factor-1, Ki-67, p63, p53 and high-molecular weight cytokeratin expressions in papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. ( 21315633 )
2011
47
Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy. ( 20797751 )
2010
48
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. ( 20551551 )
2010
49
Kikuchi disease and thyroid follicular adenoma. ( 20859864 )
2010
50
Signet-ring cell follicular adenoma of the thyroid. ( 20132181 )
2010

Variations for Follicular Adenoma

Expression for Follicular Adenoma

Search GEO for disease gene expression data for Follicular Adenoma.

Pathways for Follicular Adenoma

GO Terms for Follicular Adenoma

Biological processes related to Follicular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of epithelial to mesenchymal transition GO:0010719 9.4 NKX2-1 PTEN
2 response to pain GO:0048265 9.37 CALCA RET
3 endothelial cell migration GO:0043542 9.33 CALCA DPP4 PTEN
4 hormone biosynthetic process GO:0042446 9.32 TG TPO
5 iodide transport GO:0015705 9.26 SLC26A4 TG
6 thyroid-stimulating hormone signaling pathway GO:0038194 8.96 PAX8 TSHR
7 thyroid gland development GO:0030878 8.8 NKX2-1 PAX8 TG

Molecular functions related to Follicular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.26 CALCA CDKN1B KRT19 TSHR
2 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Follicular Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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