MCID: FLL031
MIFTS: 40

Follicular Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Follicular Adenoma

MalaCards integrated aliases for Follicular Adenoma:

Name: Follicular Adenoma 12 15 70
Follicular Adenoma of the Thyroid Gland 12
Thyroid Gland Follicular Adenoma 70
Thyroid Adenoma, Follicular 6
Thyroid Follicular Adenoma 12
Follicular Thyroid Adenoma 17
Adenoma Follicular 54

Classifications:



External Ids:

Disease Ontology 12 DOID:6204
MeSH 44 D000236
SNOMED-CT 67 55021007
UMLS 70 C0151468 C0205647

Summaries for Follicular Adenoma

MalaCards based summary : Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to atypical follicular adenoma and adenoma. An important gene associated with Follicular Adenoma is MEN1 (Menin 1), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include thyroid, lymph node and endothelial, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Follicular Adenoma

Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 atypical follicular adenoma 32.6 TG RET PAX8 CALCA
2 adenoma 31.4 TSHR TG RET MEN1 LGALS3 BRAF
3 thyroid tumor 30.9 RET PTEN BRAF
4 thyroiditis 30.8 TSHR TPO TG RET CALCA
5 thyroid carcinoma 30.8 TSHR TPO TG RET PTEN PAX8
6 goiter 30.7 TSHR TPO TG RET PAX8 NKX2-1
7 parathyroid adenoma 30.7 RET MEN1 LGALS3 CALCA
8 paraganglioma 30.7 TG RET MEN1 CALCA
9 fetal adenoma 30.6 TG CALCA
10 clear cell adenoma 30.6 TG PAX8 MEN1
11 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.6 TSHR TPO TG
12 hyperparathyroidism 30.5 RET MEN1 CALCA
13 hyperthyroidism 30.5 TSHR TPO TG CALCA
14 multinodular goiter 30.5 TSHR TPO TG PAX8 NKX2-1 KRT19
15 papillary carcinoma 30.4 TSHR TPO TG RET PPARG PAX8
16 colon adenocarcinoma 30.3 S100A4 PTEN LGALS3 DPP4 BRAF
17 multiple endocrine neoplasia 30.3 TG RET MEN1 CALCA
18 small cell carcinoma 30.3 PTEN NKX2-1 KRT19 CALCA
19 nontoxic goiter 30.3 TSHR TPO TG CALCA
20 hemangioma 30.3 RET PTEN NKX2-1 MEN1
21 neuroendocrine tumor 30.2 RET NKX2-1 MEN1 KRT19 CALCA
22 primary hyperparathyroidism 30.2 RET MEN1 CALCA
23 thyroid gland medullary carcinoma 30.1 TG RET PAX8 NKX2-1 MEN1 CALCA
24 nodular goiter 30.1 TSHR TPO TG RET LGALS3 KRT19
25 thyroid carcinoma, familial medullary 30.1 TG RET NKX2-1 MEN1 CALCA BRAF
26 hypothyroidism 30.0 TSHR TPO TG RET PAX8 NKX2-1
27 renal cell carcinoma, nonpapillary 29.9 RET PTEN PAX8 NKX2-1 KRT19 BRAF
28 thyroid gland follicular carcinoma 29.8 TSHR TPO TG TFF3 RET PTEN
29 thyroid cancer, nonmedullary, 2 29.8 TSHR TG TFF3 PTEN PPARG PAX8
30 differentiated thyroid carcinoma 29.7 TSHR TPO TG RET PPARG PAX8
31 thyroid gland disease 29.7 TSHR TPO TG RET PPARG PAX8
32 thyroid gland cancer 29.6 TSHR TPO TG SERPINB5 S100A4 RET
33 thyroid gland anaplastic carcinoma 29.2 TSHR TPO TG S100A4 RET PTEN
34 thyroid cancer, nonmedullary, 4 11.2
35 oncocytoma 11.1
36 mechanical strabismus 10.5 TPO TG
37 multicentric papillary thyroid carcinoma 10.5 TG RET
38 thyroid gland mucoepidermoid carcinoma 10.5 TG CALCA
39 colloid adenoma 10.5 TG LGALS3
40 spindle epithelial tumor with thymus-like differentiation tumor 10.5 TG CALCA
41 substernal goiter 10.5 TG CALCA
42 cervix endometriosis 10.5 MCM7 MCM2
43 aspirin allergy 10.5 TPO TG
44 isthmus cancer 10.5 TG LGALS3 CALCA
45 postsurgical hypothyroidism 10.5 TPO TG
46 basilar artery insufficiency 10.5 TPO CALCA
47 mucinous bronchioloalveolar adenocarcinoma 10.5 NKX2-1 LGALS3
48 epithelial malignant thymoma 10.5 TG CALCA
49 ovarian germ cell cancer 10.5 TG NKX2-1 KRT19
50 acute thyroiditis 10.5 TPO TG CALCA

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to Follicular Adenoma

Symptoms & Phenotypes for Follicular Adenoma

GenomeRNAi Phenotypes related to Follicular Adenoma according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 10.12 BRAF
2 Decreased viability GR00055-A-2 10.12 BRAF
3 Decreased viability GR00106-A-0 10.12 MEN1
4 Decreased viability GR00221-A-1 10.12 PPARG RET
5 Decreased viability GR00221-A-2 10.12 PPARG RET
6 Decreased viability GR00221-A-3 10.12 PPARG
7 Decreased viability GR00221-A-4 10.12 BRAF PPARG RET
8 Decreased viability GR00240-S-1 10.12 LGALS3 PAX8 TG
9 Decreased viability GR00249-S 10.12 BRAF MINPP1 SERPINB5
10 Decreased viability GR00301-A 10.12 BRAF RET
11 Decreased viability GR00381-A-1 10.12 BRAF CALCA MCM2 SERPINB5
12 Decreased viability GR00386-A-1 10.12 PPARG PTEN SERPINB5
13 Decreased viability GR00402-S-2 10.12 KRT19 PAX8 RET
14 Reduced mammosphere formation GR00396-S 9.17 BRAF MCM2 MCM7 MEN1 PAX8 PPARG

MGI Mouse Phenotypes related to Follicular Adenoma:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.44 BRAF DPP4 KRT19 LGALS3 MCM2 MCM7
2 growth/size/body region MP:0005378 10.43 BRAF DPP4 KRT19 LGALS3 MCM2 MCM7
3 behavior/neurological MP:0005386 10.36 BRAF LGALS3 MCM2 NKX2-1 PAX8 PPARG
4 endocrine/exocrine gland MP:0005379 10.35 BRAF DPP4 KRT19 MCM2 MEN1 NKX2-1
5 cardiovascular system MP:0005385 10.32 BRAF DPP4 KRT19 LGALS3 MEN1 NKX2-1
6 mortality/aging MP:0010768 10.31 BRAF DPP4 KRT19 LGALS3 MCM2 MCM7
7 immune system MP:0005387 10.3 BRAF DPP4 KRT19 LGALS3 MCM2 MEN1
8 homeostasis/metabolism MP:0005376 10.29 BRAF DPP4 LGALS3 MEN1 NKX2-1 PAX8
9 hematopoietic system MP:0005397 10.27 BRAF DPP4 LGALS3 MCM2 MCM7 PPARG
10 digestive/alimentary MP:0005381 10.26 BRAF KRT19 LGALS3 MCM2 MEN1 NKX2-1
11 embryo MP:0005380 10.2 BRAF KRT19 MCM2 MEN1 PAX8 PPARG
12 adipose tissue MP:0005375 10.14 BRAF LGALS3 MCM2 PPARG PTEN SERPINB5
13 neoplasm MP:0002006 10.11 BRAF KRT19 LGALS3 MCM2 MEN1 NKX2-1
14 nervous system MP:0003631 10.1 BRAF KRT19 LGALS3 MCM2 MEN1 NKX2-1
15 normal MP:0002873 10 BRAF KRT19 MCM2 MINPP1 NKX2-1 PAX8
16 hearing/vestibular/ear MP:0005377 9.99 BRAF DPP4 PAX8 PPARG TPO TSHR
17 limbs/digits/tail MP:0005371 9.98 BRAF PAX8 PTEN RET TG TPO
18 reproductive system MP:0005389 9.9 BRAF KRT19 LGALS3 MEN1 NKX2-1 PAX8
19 respiratory system MP:0005388 9.56 BRAF DPP4 KRT19 LGALS3 MCM2 NKX2-1
20 skeleton MP:0005390 9.32 BRAF KRT19 LGALS3 NKX2-1 PAX8 PPARG

Drugs & Therapeutics for Follicular Adenoma

Search Clinical Trials , NIH Clinical Center for Follicular Adenoma

Genetic Tests for Follicular Adenoma

Anatomical Context for Follicular Adenoma

MalaCards organs/tissues related to Follicular Adenoma:

40
Thyroid, Lymph Node, Endothelial, Breast, Prostate, Bone Marrow, Thymus

Publications for Follicular Adenoma

Articles related to Follicular Adenoma:

(show top 50) (show all 1193)
# Title Authors PMID Year
1
Somatic mutation and germline variants of MINPP1, a phosphatase gene located in proximity to PTEN on 10q23.3, in follicular thyroid carcinomas. 6
11297621 2001
2
Impact of proto-oncogene mutation detection in cytological specimens from thyroid nodules improves the diagnostic accuracy of cytology. 54 61
20130073 2010
3
BRAF mutation in solid cell nest hyperplasia associated with papillary thyroid carcinoma. A precursor lesion? 61 54
19269016 2009
4
Trefoil factor 3 immunohistochemical characterization of follicular thyroid lesions from tissue microarray. 61 54
19528408 2009
5
Differential expression of CK 19 in follicular adenoma, well-differentiated tumour of uncertain malignant potential (WDT-UMP) and follicular variant of papillary carcinoma. 61 54
19213370 2009
6
Immunohistochemical analysis of nm23 protein expression in thyroid papillary carcinoma and follicular neoplasm. 61 54
18996649 2009
7
TFF3-based candidate gene discrimination of benign and malignant thyroid tumors in a region with borderline iodine deficiency. 54 61
18198227 2008
8
Galectin-3 and CD44v6 positivity by RT-PCR method in fine needle aspirates of benign thyroid lesions. 54 61
17397496 2007
9
Diagnostic usefulness of HBME1, galectin-3, CK19, and CITED1 and evaluation of their expression in encapsulated lesions with questionable features of papillary thyroid carcinoma. 54 61
17050067 2006
10
Differential expression of the components of the plasminogen activating system in human thyroid tumour derived cell lines and papillary carcinomas. 61 54
16928445 2006
11
Cell proliferation marker MCM2, but not Ki67, is helpful for distinguishing between minimally invasive follicular carcinoma and follicular adenoma of the thyroid. 61 54
16722928 2006
12
The efficacy of the thyroid peroxidase marker for distinguishing follicular thyroid carcinoma from follicular adenoma. 54 61
16614712 2006
13
Immunohistochemical separation of follicular variant of papillary thyroid carcinoma from follicular adenoma. 61 54
17308358 2006
14
RET and p53 expression in thyroid follicular adenoma: a study of 52 cases with 14 years follow-up. 61 54
17191391 2005
15
Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness. 61 54
15902486 2005
16
Decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma. 61 54
15943828 2005
17
Benign Hürthle cell adenoma with papillary architecture: a benign lesion mimicking oncocytic papillary carcinoma. 61 54
15735853 2005
18
Immunostaining of galectin-3 and CD44v6 using fine-needle aspiration for distinguishing follicular carcinoma from adenoma. 61 54
15540177 2004
19
Galectin-3 does not reliably distinguish benign from malignant thyroid neoplasms. 54 61
15500653 2004
20
Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study. 61 54
15483349 2004
21
Immunohistochemical localisation of RET and p53 mutant protein of thyroid lesions in a North-Eastern Malaysian population and its prognostic implications. 54 61
15203751 2004
22
High-throughput differential screening of mRNAs by serial analysis of gene expression: decreased expression of trefoil factor 3 mRNA in thyroid follicular carcinomas. 54 61
15083192 2004
23
S100A4 expression is an early event of papillary carcinoma of the thyroid. 61 54
15713996 2004
24
Diagnostic applicability of dipeptidyl aminopeptidase IV activity in cytological samples for differentiating follicular thyroid carcinoma from follicular adenoma. 54 61
14718282 2004
25
Cytokeratin subtypes in thyroid tumours: immunohistochemical study with emphasis on the follicular variant of papillary carcinoma. 61 54
14974863 2003
26
High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. 54 61
12907632 2003
27
Peroxisome proliferator-activated receptor gamma expression in follicular-patterned thyroid lesions. Caveats for the use of immunohistochemical studies. 54 61
12931546 2003
28
BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC. 54 61
12881714 2003
29
Expression of RET in follicular cell-derived tumors of the thyroid gland: prevalence and implication of morphological type. 54 61
12608895 2003
30
Usefulness of galectin-3 immunohistochemistry in differential diagnosis between thyroid follicular carcinoma and follicular adenoma. 54 61
14575419 2003
31
Galectin-3 messenger ribonucleic acid and protein are expressed in benign thyroid tumors. 61 54
12364477 2002
32
Galectin-3 is not an universal marker of malignancy in thyroid nodular disease in children and adolescents. 54 61
12213909 2002
33
Characterization and semiquantitative analyses of pendrin expressed in normal and tumoral human thyroid tissues. 54 61
11932304 2002
34
Diagnostic utility of cytokeratin 19 expression in multinodular goiter with papillary areas and papillary carcinoma of thyroid. 54 61
12446919 2002
35
uPA receptor expression in benign and malignant thyroid tumors. 61 54
12017319 2002
36
Cytokeratin 19 immunoreactivity in the diagnosis of papillary thyroid carcinoma: a note of caution. 54 61
11710686 2001
37
Galectin-3 as a presurgical immunocytodiagnostic marker of minimally invasive follicular thyroid carcinoma. 61 54
11701669 2001
38
Follicular adenoma with papillary architecture: a lesion mimicking papillary thyroid carcinoma. 54 61
11454041 2001
39
Ret oncogene protein expression in papillary thyroid carcinoma and related lesions. 54 61
11504372 2001
40
Clinical significance of E-cadherin expression in thyroid neoplasms. 54 61
11276021 2001
41
Differential reactivity for galectin-3 in Hürthle cell adenomas and carcinomas. 61 54
11740048 2001
42
Fine-needle aspiration biopsy of papillary thyroid carcinoma: diagnostic utility of cytokeratin 19 immunostaining. 54 61
11038428 2000
43
Expression of the cadherin-catenin complex in well-differentiated human thyroid neoplastic tissue. 61 54
10595458 1999
44
Role of serum thyroglobulin in the pre-operative evaluation of follicular thyroid tumours. 61 54
9870733 1998
45
The role of cell cycle regulatory proteins, cyclin D1, cyclin E, and p27 in thyroid carcinogenesis. 61 54
9824112 1998
46
c-Met expression of thyroid tissue with special reference to papillary carcinoma. 61 54
9788259 1998
47
Ret oncogene activation in papillary thyroid carcinoma: prevalence and implication on the histological parameters. 54 61
9635675 1998
48
Expression of splice variants of CD44 in thyroid neoplasms derived from follicular cells. 61 54
9589486 1998
49
Integrins in thyroid tissue: upregulation of alpha2beta1 in anaplastic thyroid carcinoma. 61 54
9461325 1998
50
Thyroid paraganglioma: a clinicopathologic and immunohistochemical study of three cases. 54 61
9236830 1997

Variations for Follicular Adenoma

ClinVar genetic disease variations for Follicular Adenoma:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 MINPP1 MINPP1, IVS3, T-A, +34 SNV Pathogenic 5023 GRCh37:
GRCh38:
2 MEN1 NM_000244.3(MEN1):c.669+1del Deletion Pathogenic 374107 rs1057518903 GRCh37: 11:64575362-64575362
GRCh38: 11:64807890-64807890

Expression for Follicular Adenoma

Search GEO for disease gene expression data for Follicular Adenoma.

Pathways for Follicular Adenoma

GO Terms for Follicular Adenoma

Cellular components related to Follicular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MCM complex GO:0042555 8.96 MCM7 MCM2
2 CMG complex GO:0071162 8.62 MCM7 MCM2

Biological processes related to Follicular Adenoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 response to drug GO:0042493 9.83 RET PTEN PPARG MCM7
2 thyroid hormone generation GO:0006590 9.51 TPO TG
3 DNA unwinding involved in DNA replication GO:0006268 9.49 MCM7 MCM2
4 negative regulation of telomerase activity GO:0051974 9.48 PPARG MEN1
5 double-strand break repair via break-induced replication GO:0000727 9.46 MCM7 MCM2
6 negative regulation of cell cycle G1/S phase transition GO:1902807 9.43 PTEN MEN1
7 cellular response to nerve growth factor stimulus GO:1990090 9.43 PTEN CALCA BRAF
8 hormone biosynthetic process GO:0042446 9.4 TPO TG
9 pre-replicative complex assembly involved in nuclear cell cycle DNA replication GO:0006267 9.37 MCM7 MCM2
10 endothelial cell migration GO:0043542 9.33 PTEN DPP4 CALCA
11 regulation of axon regeneration GO:0048679 9.32 PTEN BRAF
12 thyroid-stimulating hormone signaling pathway GO:0038194 8.96 TSHR PAX8
13 thyroid gland development GO:0030878 8.92 TG PAX8 NKX2-1 BRAF

Molecular functions related to Follicular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.23 TSHR TG TFF3 SERPINB5 S100A4 RET
2 transcription regulatory region sequence-specific DNA binding GO:0000976 9.46 PPARG PAX8 NKX2-1 MEN1
3 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity GO:0051717 8.96 PTEN MINPP1
4 thyroid-stimulating hormone receptor activity GO:0004996 8.62 TSHR PAX8

Sources for Follicular Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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