MCID: FLL031
MIFTS: 41

Follicular Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Follicular Adenoma

MalaCards integrated aliases for Follicular Adenoma:

Name: Follicular Adenoma 12 15 73
Follicular Adenoma of the Thyroid Gland 12
Thyroid Gland Follicular Adenoma 73
Thyroid Follicular Adenoma 12
Adenoma Follicular 55

Classifications:



External Ids:

Disease Ontology 12 DOID:6204
MeSH 44 D000236
SNOMED-CT 68 55021007

Summaries for Follicular Adenoma

MalaCards based summary : Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to atypical follicular adenoma and small cell carcinoma. An important gene associated with Follicular Adenoma is LGALS3 (Galectin 3), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Human Thyroid Stimulating Hormone (TSH) signaling pathway. The drugs Iodine and Formaldehyde have been mentioned in the context of this disorder. Affiliated tissues include thyroid, bone and colon, and related phenotypes are Increased shRNA abundance and endocrine/exocrine gland

Related Diseases for Follicular Adenoma

Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 101)
# Related Disease Score Top Affiliating Genes
1 atypical follicular adenoma 34.3 CALCA TG
2 small cell carcinoma 30.0 CALCA NKX2-1 PTEN
3 primary hyperparathyroidism 29.9 CALCA CDKN1B RET
4 hyperparathyroidism 29.9 CALCA CDKN1B RET
5 thyroiditis 29.8 CALCA RET TG TPO TSHR
6 cowden disease 29.6 CALCA PTEN RET TG
7 thyroid cancer, nonmedullary, 1 29.5 LGALS3 NKX2-1 PAX8 RET TG
8 nodular goiter 27.9 CALCA LGALS3 RET TG TPO TSHR
9 papillary carcinoma 26.7 CALCA KRT19 LGALS3 NKX2-1 PAX8 RET
10 goiter 26.2 CALCA LGALS3 NKX2-1 PAX8 SLC26A4 TG
11 multinodular goiter 26.2 CALCA NKX2-1 PAX8 SLC26A4 TG TPO
12 hypothyroidism 25.7 CALCA NKX2-1 PAX8 RET SLC26A4 TG
13 thyroid cancer, nonmedullary, 2 25.0 CALCA DPP4 KRT19 LGALS3 NKX2-1 PAX8
14 thyroid cancer 23.5 CALCA CDKN1B KRT19 LGALS3 NKX2-1 PAX8
15 oncocytoma 11.0
16 familial thyroid dyshormonogenesis 10.8 TG TPO
17 subacute lymphocytic thyroiditis 10.8 TG TPO
18 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.8 TG TPO
19 mucoepidermoid thyroid carcinoma 10.8 CALCA TG
20 suppurative thyroiditis 10.7 CALCA TG
21 adenoma 10.7
22 mucinous bronchioloalveolar adenocarcinoma 10.7 LGALS3 NKX2-1
23 thyroid sarcoma 10.7 CALCA TG
24 malignant teratoma 10.7 NKX2-1 TG
25 plummer's disease 10.7 TG TPO
26 corneal abscess 10.6 KRT19 PTEN
27 acute thyroiditis 10.6 CALCA TG
28 premature menopause 10.6 TG TPO
29 hypoadrenalism 10.6 CALCA TG
30 hypothyroidism, congenital, nongoitrous, 4 10.6 TG TPO
31 ovarian germ cell teratoma 10.5 NKX2-1 RET TG
32 ovarian germ cell cancer 10.5 NKX2-1 RET TG
33 pernicious anemia 10.5 TG TPO
34 chordoma 10.5 KRT19 LGALS3 PTEN
35 dyshormonogenic goiter 10.5 SLC26A4 TG
36 parathyroid carcinoma 10.5 CALCA LGALS3 RET
37 ovarian cystic teratoma 10.4 CALCA NKX2-1 TG
38 hypothyroidism, thyroidal or athyroidal, with spiky hair and cleft palate 10.4 TG TPO
39 respiratory system cancer 10.4 KRT19 NKX2-1 PTEN
40 polyposis, skin pigmentation, alopecia, and fingernail changes 10.4 KRT19 PTEN
41 cell type cancer 10.4 KRT19 NKX2-1 PTEN
42 multiple endocrine neoplasia, type iv 10.4 CDKN1B RET
43 water-clear cell adenoma 10.4 PAX8 TG
44 renal pelvis adenocarcinoma 10.3 KRT19 PAX8
45 neuroendocrine tumor 10.3 CALCA KRT19 NKX2-1
46 mixed type thymoma 10.2 PAX8 PTEN
47 celiac disease 1 10.2 DPP4 TG TPO
48 multiple endocrine neoplasia 10.2 CALCA CDKN1B RET
49 renal pelvis carcinoma 10.2 KRT19 PAX8
50 amyloid tumor 10.1 CALCA TG

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to Follicular Adenoma

Symptoms & Phenotypes for Follicular Adenoma

GenomeRNAi Phenotypes related to Follicular Adenoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance GR00327-A 8.92 LGALS3 MCM2 CALCA CDKN1B

MGI Mouse Phenotypes related to Follicular Adenoma:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 10.34 RET PAX8 PTEN SLC26A4 TPO TSHR
2 growth/size/body region MP:0005378 10.29 RET PAX8 PTEN TPO TSHR TG
3 cellular MP:0005384 10.25 NKX2-1 RET PAX8 PTEN TP53BP1 TSHR
4 homeostasis/metabolism MP:0005376 10.23 NKX2-1 RET PAX8 SLC26A4 PTEN TPO
5 behavior/neurological MP:0005386 10.21 PTEN NKX2-1 RET PAX8 SLC26A4 TSHR
6 digestive/alimentary MP:0005381 10.14 RET SLC26A4 PTEN NKX2-1 LGALS3 CDKN1B
7 mortality/aging MP:0010768 10.14 NKX2-1 RET PAX8 PTEN TP53BP1 TPO
8 hematopoietic system MP:0005397 10.13 RET PTEN TP53BP1 TPO TSHR TG
9 immune system MP:0005387 10.09 PTEN RET SLC26A4 TP53BP1 TPO TSHR
10 nervous system MP:0003631 10.06 RET PAX8 SLC26A4 PTEN NKX2-1 TSHR
11 neoplasm MP:0002006 10.02 RET PTEN TSHR TP53BP1 MCM2 KRT19
12 hearing/vestibular/ear MP:0005377 9.89 PAX8 TPO SLC26A4 TSHR CDKN1B
13 reproductive system MP:0005389 9.85 RET PAX8 SLC26A4 PTEN TSHR TP53BP1
14 renal/urinary system MP:0005367 9.73 PTEN PAX8 RET SLC26A4 LGALS3 CDKN1B
15 respiratory system MP:0005388 9.43 PTEN NKX2-1 RET LGALS3 CDKN1B MCM2
16 skeleton MP:0005390 9.28 NKX2-1 PAX8 SLC26A4 PTEN TPO TSHR

Drugs & Therapeutics for Follicular Adenoma

Drugs for Follicular Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Iodine Approved, Investigational 7553-56-2 807
2
Formaldehyde Approved, Vet_approved 50-00-0 712
3 cadexomer iodine

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of a New CZT System Unknown status NCT01084356
2 Biomarkers to Distinguish Benign From Malignant Thyroid Neoplasm Completed NCT01433809
3 Molecular Markers in Thyroid Cancer Completed NCT00598364
4 Expression of NIS Protein and mRNA in Thyroid Tumors Completed NCT00459498
5 Alterations in Muscle's Functional Characteristics After Parathyroid Surgery for Primary Hyperparathyroidism. Recruiting NCT03091140
6 French Childhood Cancer Survivor Study Recruiting NCT01620372
7 Expression of Protein Convertases in Thyroid Nodules Enrolling by invitation NCT03160482
8 ctDNA in Patients With Thyroid Nodules Terminated NCT02778412

Search NIH Clinical Center for Follicular Adenoma

Genetic Tests for Follicular Adenoma

Anatomical Context for Follicular Adenoma

MalaCards organs/tissues related to Follicular Adenoma:

41
Thyroid, Bone, Colon, Lung

Publications for Follicular Adenoma

Articles related to Follicular Adenoma:

(show top 50) (show all 128)
# Title Authors Year
1
Artificial neural network model to distinguish follicular adenoma from follicular carcinoma on fine needle aspiration of thyroid. ( 29266871 )
2018
2
Tumour growth rate of follicular thyroid carcinoma is not different from that of follicular adenoma. ( 29509975 )
2018
3
A six-gene panel to label follicular adenoma, low- and high-risk follicular thyroid carcinoma. ( 29298844 )
2018
4
Carney complex: a case with thyroid follicular adenoma without a PRKAR1A mutation. ( 29666959 )
2018
5
TERT, HRAS, and EIF1AX Mutations in a Patient with Follicular Adenoma. ( 29669480 )
2018
6
Hashimoto's thyroiditis, nodular goiter or follicular adenoma combined with papillary thyroid carcinoma play protective role in patients. ( 29788738 )
2018
7
A rare presentation: A case report of osseous metaplasia and mature bone formation in a follicular adenoma of the thyroid. ( 28648877 )
2017
8
Tumor-to-tumor metastasis: Small cell carcinoma lung metastasising into a follicular adenoma of the thyroid. ( 28195115 )
2017
9
Follicular adenoma in ectopic thyroid. A case-report. ( 28946030 )
2017
10
Can Nodular Hyperplasia of the Thyroid Gland be Differentiated From Follicular Adenoma and Follicular Carcinoma by Ultrasonography? ( 27870787 )
2016
11
Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma. ( 27626165 )
2016
12
Incidental ectopic thyroid follicular adenoma on myocardial perfusion imaging. ( 26122882 )
2016
13
Thyroid follicular adenoma with numerous intracytoplasmic lumina mimicking yellow bodies: a case report. ( 27146719 )
2016
14
Papillary Thyroid Carcinoma Arising Within a Follicular Adenoma: A Case Report, Ultrasound Features, and Considerations. ( 27110655 )
2016
15
Expression of ARE-binding proteins AUF1 and HuR in follicular adenoma and carcinoma of thyroid gland. ( 26925783 )
2016
16
Association between p53-binding protein 1 expression and genomic instability in oncocytic follicular adenoma of the thyroid. ( 26935218 )
2016
17
Appearance of HA1rthle cell carcinoma soon after surgical extirpation of HA1rthle cell adenoma and follicular adenoma of the thyroid gland. ( 25810698 )
2015
18
Not All Post-FNA Spindle Cell Proliferations in the Thyroid Are of Myofibroblastic Origin: Follicular Adenoma with Spindle Cell Metaplasia. ( 26490689 )
2015
19
Determination-of apoptosis and cell cycle modulators (p16, p21, p27, p53, BCL-2, Bax, BCL-xL, and cyclin D1) in thyroid follicular carcinoma, follicular adenoma, and adenomatous nodules via a tissue microarray method. ( 26422859 )
2015
20
Comparison of microarray expression profiles between follicular variant of papillary thyroid carcinomas and follicular adenomas of the thyroid. ( 25923053 )
2015
21
Identification of Novel Biomarker and Therapeutic Target Candidates for Diagnosis and Treatment of Follicular Adenoma. ( 26543076 )
2015
22
Risk of thyroid follicular adenoma among children and adolescents in Belarus exposed to iodine-131 after the Chornobyl accident. ( 26443421 )
2015
23
Better understanding in the differentiation of thyroid follicular adenoma, follicular carcinoma, and follicular variant of papillary carcinoma: a retrospective study. ( 25309594 )
2014
24
Meningioma like tumour of thyroid: a rare variant of follicular adenoma. ( 24640816 )
2014
25
Sonographic features of thyroid follicular carcinoma in comparison with thyroid follicular adenoma. ( 24449724 )
2014
26
How should a follicular adenoma with papillary architecture be classified on thyroid FNA? Case report with histological correlation. ( 25073478 )
2014
27
Unusual association of primary hyperparathyroidism, papillary thyroid carcinoma, and follicular adenoma in a young female. ( 23776923 )
2013
28
The unique liquid-based cytologic findings of thyroid signet-ring follicular adenoma: a report of two cases with fine needle aspiration cytology. ( 23220878 )
2013
29
Thyroid Follicular Adenoma with Accumulation of Collagen Type IV in a Common Marmoset (Callithrix jacchus). ( 24060155 )
2013
30
Molecular differences between human thyroid follicular adenoma and carcinoma revealed by analysis of a murine model of thyroid cancer. ( 23751876 )
2013
31
A case of asymptomatic riedel thyroiditis with follicular adenoma in a patient with a multinodular goiter: an unusual association. ( 24783021 )
2012
32
Genetic studies in a coexistence of acromegaly, pheochromocytoma, gastrointestinal stromal tumor (GIST) and thyroid follicular adenoma. ( 23295290 )
2012
33
Follicular adenoma with extensive extracellular mucin deposition: report on two cases. ( 23236259 )
2012
34
Follicular adenoma presenting as lateral aberrant thyroid. ( 21854673 )
2012
35
Value of immunohistochemical expression of p27 and galectin-3 in differentiation between follicular adenoma and follicular carcinoma. ( 22553813 )
2012
36
Examination of CD26/DPPIV, p53, and PTEN expression in thyroid follicular adenoma. ( 22086610 )
2012
37
Fine needle aspiration biopsy of an unusual follicular adenoma with sebaceous-like features. ( 22527948 )
2012
38
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. ( 21623114 )
2011
39
Cytologic features of focal papillary thyroid carcinoma arising within follicular adenoma: a masked cytomorphologic analysis of 17 cases. ( 22156462 )
2011
40
Thyroid follicular adenoma composed of lipid-rich cells. ( 21165779 )
2011
41
Comment on: synchronous occurrence of anaplastic, follicular, and papillary carcinoma with follicular adenoma in thyroid gland. ( 21623130 )
2011
42
Follicular adenoma and carcinoma of the thyroid gland. ( 21482585 )
2011
43
Differential diagnosis of follicular cancer and follicular adenoma using an expert system based on a set of qualitative signs of cell atypia. ( 22611752 )
2011
44
Squamous cell components in a thyroid follicular adenoma: significant evidence of follicular cell origin by histomorphological, immunohistochemical and molecular analyses. ( 21951666 )
2011
45
Comparison of proliferating cell nuclear antigen, thyroid transcription factor-1, Ki-67, p63, p53 and high-molecular weight cytokeratin expressions in papillary thyroid carcinoma, follicular carcinoma, and follicular adenoma. ( 21315633 )
2011
46
Expression of the sonic hedgehog pathway molecules in synchronous follicular adenoma and papillary carcinoma of the thyroid gland in predicting malignancy. ( 20797751 )
2010
47
Synchronous occurrence of anaplastic, follicular and papillary carcinomas with follicular adenoma in thyroid gland. ( 20551551 )
2010
48
Kikuchi disease and thyroid follicular adenoma. ( 20859864 )
2010
49
Signet-ring cell follicular adenoma of the thyroid. ( 20132181 )
2010
50
Clear cell follicular adenoma of the thyroid--a challenge in intra-operative diagnostics. ( 19235130 )
2010

Variations for Follicular Adenoma

Expression for Follicular Adenoma

Search GEO for disease gene expression data for Follicular Adenoma.

Pathways for Follicular Adenoma

GO Terms for Follicular Adenoma

Biological processes related to Follicular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of epithelial to mesenchymal transition GO:0010719 9.4 NKX2-1 PTEN
2 response to pain GO:0048265 9.37 CALCA RET
3 endothelial cell migration GO:0043542 9.33 CALCA DPP4 PTEN
4 hormone biosynthetic process GO:0042446 9.32 TG TPO
5 iodide transport GO:0015705 9.26 SLC26A4 TG
6 thyroid-stimulating hormone signaling pathway GO:0038194 8.96 PAX8 TSHR
7 thyroid gland development GO:0030878 8.8 NKX2-1 PAX8 TG

Molecular functions related to Follicular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid-stimulating hormone receptor activity GO:0004996 8.62 PAX8 TSHR

Sources for Follicular Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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