MCID: FLL031
MIFTS: 37

Follicular Adenoma

Categories: Cancer diseases, Endocrine diseases
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Aliases & Classifications for Follicular Adenoma

MalaCards integrated aliases for Follicular Adenoma:

Name: Follicular Adenoma 11 14 71
Follicular Adenoma of the Thyroid Gland 11
Thyroid Gland Follicular Adenoma 71
Thyroid Follicular Adenoma 11
Follicular Thyroid Adenoma 16
Adenoma Follicular 53

Classifications:



External Ids:

Disease Ontology 11 DOID:6204
MeSH 43 D000236
SNOMED-CT 68 55021007
UMLS 71 C0151468 C0205647

Summaries for Follicular Adenoma

MalaCards based summary: Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to atypical follicular adenoma and thyroid carcinoma. An important gene associated with Follicular Adenoma is LGALS3 (Galectin 3), and among its related pathways/superpathways are Signal Transduction and Thyroid hormones production and peripheral downstream signaling effects. Affiliated tissues include thyroid, lymph node and endothelial, and related phenotypes are Reduced mammosphere formation and nervous system

Related Diseases for Follicular Adenoma

Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 199)
# Related Disease Score Top Affiliating Genes
1 atypical follicular adenoma 32.4 TG RET PAX8 CALCA
2 thyroid carcinoma 31.4 TG RET BRAF
3 adenoma 31.2 TSHR TG RET LGALS3 KRT19 GNAS
4 thyroid tumor 30.7 RET PTEN BRAF
5 thyroiditis 30.6 TSHR TPO TG RET CALCA
6 hypothyroidism, congenital, nongoitrous, 2 30.5 TSHR TG SLC26A4 PAX8 NKX2-1
7 fetal adenoma 30.5 TG CALCA
8 graves disease 1 30.3 TSHR TPO TG CALCA
9 nontoxic goiter 30.3 TSHR TPO TG CALCA
10 paraganglioma 30.3 TG RET NKX2-1 KRT19 CALCA
11 parathyroid adenoma 30.3 TG RET LGALS3 GNAS CALCA
12 thyroid cancer, nonmedullary, 2 30.2 TSHR TG TFF3 PTEN PPARG PAX8
13 subacute thyroiditis 30.2 TSHR TPO TG
14 cystic teratoma 30.2 TG PAX8 NKX2-1
15 hyperthyroidism 30.1 TSHR TPO TG GNAS CALCA
16 multiple endocrine neoplasia 30.0 TG RET GNAS CALCA
17 hemangioma 30.0 RET PTEN NKX2-1 CALCA
18 neuroendocrine tumor 29.9 RET PAX8 NKX2-1 KRT19 CALCA
19 colon adenocarcinoma 29.9 S100A4 PPARG LGALS3 GNAS BRAF
20 thyroid gland medullary carcinoma 29.9 TG RET PAX8 NKX2-1 CALCA
21 thyroid carcinoma, familial medullary 29.9 TG RET NKX2-1 CALCA BRAF
22 goiter 29.9 TSHR TPO TG SLC26A4 RET PAX8
23 gastrointestinal stromal tumor 29.8 RET PTEN MET BRAF
24 differentiated thyroid carcinoma 29.8 RET PPARG PAX8 NKX2-1 BRAF
25 nodular goiter 29.8 TSHR TPO TG RET LGALS3 KRT19
26 hashimoto thyroiditis 29.7 TSHR TPO TG SLC26A4 RET LGALS3
27 adenocarcinoma 29.7 RET PTEN NKX2-1 MET BRAF
28 thyroid gland follicular carcinoma 29.7 TSHR TPO TG TFF3 SLC26A4 RET
29 papillary carcinoma 29.6 TSHR TPO TG RET PPARG PAX8
30 lung cancer susceptibility 3 29.6 NKX2-1 MET KRT19 GNAS BRAF
31 hypothyroidism 29.5 TSHR TPO TG SLC26A4 RET PAX8
32 renal cell carcinoma, nonpapillary 29.4 RET PTEN PAX8 NKX2-1 MET KRT19
33 multinodular goiter 29.3 TSHR TPO TG SLC26A4 RET PTEN
34 thyroid gland cancer 29.2 TSHR TPO TG SERPINB5 S100A4 RET
35 thyroid gland anaplastic carcinoma 28.6 TSHR TPO TG SLC26A4 S100A4 RET
36 thyroid cancer, nonmedullary, 4 11.2
37 oncocytoma 11.1
38 thyroid cancer, nonmedullary, 1 10.4
39 mechanical strabismus 10.4 TPO TG
40 multicentric papillary thyroid carcinoma 10.4 TG RET
41 thyroid gland mucoepidermoid carcinoma 10.4 TG PAX8
42 vulvar keratinizing squamous cell carcinoma 10.4 TG LGALS3 KRT19
43 renal pelvis adenocarcinoma 10.4 PAX8 KRT19
44 carotid body cancer 10.4 TG NKX2-1
45 heart leiomyosarcoma 10.4 TG LGALS3 KRT19
46 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.3 TPO TG
47 epithelial malignant thymoma 10.3 TG CALCA
48 isthmus cancer 10.3 TG LGALS3 CALCA
49 thymus clear cell carcinoma 10.3 PAX8 NKX2-1
50 neurohypophysis granular cell tumor 10.3 NKX2-1 CALCA

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to Follicular Adenoma

Symptoms & Phenotypes for Follicular Adenoma

GenomeRNAi Phenotypes related to Follicular Adenoma according to GeneCards Suite gene sharing:

25
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 no effect GR00402-S-1 10.19 BRAF CALCA GNAS KRT19 LGALS3 MCM2
2 no effect GR00402-S-2 10.19 BRAF CALCA GNAS LGALS3 MCM2 MCM7
3 Reduced mammosphere formation GR00396-S 9.5 BRAF GNAS MCM2 MCM7 PAX8 PPARG

MGI Mouse Phenotypes related to Follicular Adenoma:

45 (show all 24)
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 10.47 BRAF CALCA GNAS KRT19 LGALS3 MCM2
2 homeostasis/metabolism MP:0005376 10.46 BRAF CALCA GNAS LGALS3 MET NKX2-1
3 growth/size/body region MP:0005378 10.44 BRAF GNAS KRT19 LGALS3 MCM2 MCM7
4 neoplasm MP:0002006 10.43 BRAF CALCA GNAS KRT19 LGALS3 MCM2
5 normal MP:0002873 10.42 BRAF CALCA GNAS KRT19 MCM2 MET
6 endocrine/exocrine gland MP:0005379 10.4 BRAF GNAS KRT19 LGALS3 MCM2 MET
7 cellular MP:0005384 10.35 BRAF GNAS KRT19 LGALS3 MCM2 MCM7
8 behavior/neurological MP:0005386 10.34 BRAF CALCA GNAS LGALS3 MCM2 MET
9 renal/urinary system MP:0005367 10.29 BRAF CALCA GNAS LGALS3 MET PAX8
10 immune system MP:0005387 10.28 BRAF GNAS KRT19 LGALS3 MCM2 MET
11 digestive/alimentary MP:0005381 10.27 BRAF GNAS KRT19 LGALS3 MCM2 MET
12 embryo MP:0005380 10.25 BRAF CALCA GNAS KRT19 MCM2 MET
13 limbs/digits/tail MP:0005371 10.23 BRAF GNAS MET PAX8 PTEN RET
14 no phenotypic analysis MP:0003012 10.21 GNAS KRT19 MET NKX2-1 PAX8 PPARG
15 hearing/vestibular/ear MP:0005377 10.2 BRAF CALCA GNAS PAX8 PPARG SLC26A4
16 cardiovascular system MP:0005385 10.2 BRAF CALCA GNAS KRT19 LGALS3 MET
17 muscle MP:0005369 10.19 BRAF GNAS MCM2 MET PPARG PTEN
18 adipose tissue MP:0005375 10.11 BRAF GNAS LGALS3 MCM2 PPARG PTEN
19 respiratory system MP:0005388 10.07 BRAF CALCA GNAS KRT19 LGALS3 MCM2
20 skeleton MP:0005390 10.07 BRAF CALCA GNAS KRT19 LGALS3 NKX2-1
21 reproductive system MP:0005389 10.06 BRAF KRT19 LGALS3 NKX2-1 PAX8 PPARG
22 hematopoietic system MP:0005397 9.93 BRAF GNAS LGALS3 MCM2 MCM7 PPARG
23 mortality/aging MP:0010768 9.89 BRAF CALCA GNAS KRT19 LGALS3 MCM2
24 integument MP:0010771 9.28 BRAF CALCA GNAS KRT19 LGALS3 MCM2

Drugs & Therapeutics for Follicular Adenoma

Search Clinical Trials, NIH Clinical Center for Follicular Adenoma

Genetic Tests for Follicular Adenoma

Anatomical Context for Follicular Adenoma

Organs/tissues related to Follicular Adenoma:

MalaCards : Thyroid, Lymph Node, Endothelial, Salivary Gland, Bone, Lung, Bone Marrow

Publications for Follicular Adenoma

Articles related to Follicular Adenoma:

(show top 50) (show all 1346)
# Title Authors PMID Year
1
Impact of proto-oncogene mutation detection in cytological specimens from thyroid nodules improves the diagnostic accuracy of cytology. 53 62
20130073 2010
2
BRAF mutation in solid cell nest hyperplasia associated with papillary thyroid carcinoma. A precursor lesion? 53 62
19269016 2009
3
Trefoil factor 3 immunohistochemical characterization of follicular thyroid lesions from tissue microarray. 53 62
19528408 2009
4
Immunohistochemical analysis of nm23 protein expression in thyroid papillary carcinoma and follicular neoplasm. 53 62
18996649 2009
5
Differential expression of CK 19 in follicular adenoma, well-differentiated tumour of uncertain malignant potential (WDT-UMP) and follicular variant of papillary carcinoma. 53 62
19213370 2009
6
TFF3-based candidate gene discrimination of benign and malignant thyroid tumors in a region with borderline iodine deficiency. 53 62
18198227 2008
7
Galectin-3 and CD44v6 positivity by RT-PCR method in fine needle aspirates of benign thyroid lesions. 53 62
17397496 2007
8
Diagnostic usefulness of HBME1, galectin-3, CK19, and CITED1 and evaluation of their expression in encapsulated lesions with questionable features of papillary thyroid carcinoma. 53 62
17050067 2006
9
Differential expression of the components of the plasminogen activating system in human thyroid tumour derived cell lines and papillary carcinomas. 53 62
16928445 2006
10
Cell proliferation marker MCM2, but not Ki67, is helpful for distinguishing between minimally invasive follicular carcinoma and follicular adenoma of the thyroid. 53 62
16722928 2006
11
The efficacy of the thyroid peroxidase marker for distinguishing follicular thyroid carcinoma from follicular adenoma. 53 62
16614712 2006
12
Immunohistochemical separation of follicular variant of papillary thyroid carcinoma from follicular adenoma. 53 62
17308358 2006
13
RET and p53 expression in thyroid follicular adenoma: a study of 52 cases with 14 years follow-up. 53 62
17191391 2005
14
Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness. 53 62
15902486 2005
15
Decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma. 53 62
15943828 2005
16
Benign Hürthle cell adenoma with papillary architecture: a benign lesion mimicking oncocytic papillary carcinoma. 53 62
15735853 2005
17
Immunostaining of galectin-3 and CD44v6 using fine-needle aspiration for distinguishing follicular carcinoma from adenoma. 53 62
15540177 2004
18
Galectin-3 does not reliably distinguish benign from malignant thyroid neoplasms. 53 62
15500653 2004
19
Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study. 53 62
15483349 2004
20
Immunohistochemical localisation of RET and p53 mutant protein of thyroid lesions in a North-Eastern Malaysian population and its prognostic implications. 53 62
15203751 2004
21
High-throughput differential screening of mRNAs by serial analysis of gene expression: decreased expression of trefoil factor 3 mRNA in thyroid follicular carcinomas. 53 62
15083192 2004
22
S100A4 expression is an early event of papillary carcinoma of the thyroid. 53 62
15713996 2004
23
Diagnostic applicability of dipeptidyl aminopeptidase IV activity in cytological samples for differentiating follicular thyroid carcinoma from follicular adenoma. 53 62
14718282 2004
24
Cytokeratin subtypes in thyroid tumours: immunohistochemical study with emphasis on the follicular variant of papillary carcinoma. 53 62
14974863 2003
25
Peroxisome proliferator-activated receptor gamma expression in follicular-patterned thyroid lesions. Caveats for the use of immunohistochemical studies. 53 62
12931546 2003
26
High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. 53 62
12907632 2003
27
BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC. 53 62
12881714 2003
28
Expression of RET in follicular cell-derived tumors of the thyroid gland: prevalence and implication of morphological type. 53 62
12608895 2003
29
Usefulness of galectin-3 immunohistochemistry in differential diagnosis between thyroid follicular carcinoma and follicular adenoma. 53 62
14575419 2003
30
Galectin-3 messenger ribonucleic acid and protein are expressed in benign thyroid tumors. 53 62
12364477 2002
31
Galectin-3 is not an universal marker of malignancy in thyroid nodular disease in children and adolescents. 53 62
12213909 2002
32
Characterization and semiquantitative analyses of pendrin expressed in normal and tumoral human thyroid tissues. 53 62
11932304 2002
33
Diagnostic utility of cytokeratin 19 expression in multinodular goiter with papillary areas and papillary carcinoma of thyroid. 53 62
12446919 2002
34
uPA receptor expression in benign and malignant thyroid tumors. 53 62
12017319 2002
35
Cytokeratin 19 immunoreactivity in the diagnosis of papillary thyroid carcinoma: a note of caution. 53 62
11710686 2001
36
Galectin-3 as a presurgical immunocytodiagnostic marker of minimally invasive follicular thyroid carcinoma. 53 62
11701669 2001
37
Follicular adenoma with papillary architecture: a lesion mimicking papillary thyroid carcinoma. 53 62
11454041 2001
38
Ret oncogene protein expression in papillary thyroid carcinoma and related lesions. 53 62
11504372 2001
39
Clinical significance of E-cadherin expression in thyroid neoplasms. 53 62
11276021 2001
40
Differential reactivity for galectin-3 in Hürthle cell adenomas and carcinomas. 53 62
11740048 2001
41
Fine-needle aspiration biopsy of papillary thyroid carcinoma: diagnostic utility of cytokeratin 19 immunostaining. 53 62
11038428 2000
42
Expression of the cadherin-catenin complex in well-differentiated human thyroid neoplastic tissue. 53 62
10595458 1999
43
Role of serum thyroglobulin in the pre-operative evaluation of follicular thyroid tumours. 53 62
9870733 1998
44
The role of cell cycle regulatory proteins, cyclin D1, cyclin E, and p27 in thyroid carcinogenesis. 53 62
9824112 1998
45
c-Met expression of thyroid tissue with special reference to papillary carcinoma. 53 62
9788259 1998
46
Ret oncogene activation in papillary thyroid carcinoma: prevalence and implication on the histological parameters. 53 62
9635675 1998
47
Expression of splice variants of CD44 in thyroid neoplasms derived from follicular cells. 53 62
9589486 1998
48
Integrins in thyroid tissue: upregulation of alpha2beta1 in anaplastic thyroid carcinoma. 53 62
9461325 1998
49
Thyroid paraganglioma: a clinicopathologic and immunohistochemical study of three cases. 53 62
9236830 1997
50
Measuring serum thyroglobulin in patients with follicular thyroid nodule: its diagnostic implications. 53 62
9152633 1997

Variations for Follicular Adenoma

Expression for Follicular Adenoma

Search GEO for disease gene expression data for Follicular Adenoma.

Pathways for Follicular Adenoma

GO Terms for Follicular Adenoma

Biological processes related to Follicular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 epithelial cell differentiation GO:0030855 9.7 PPARG PAX8 LGALS3 KRT19
2 activation of adenylate cyclase activity GO:0007190 9.65 TSHR GNAS CALCA
3 iodide transport GO:0015705 9.62 TG SLC26A4
4 regulation of axon regeneration GO:0048679 9.37 PTEN BRAF
5 thyroid-stimulating hormone signaling pathway GO:0038194 9.26 TSHR PAX8
6 thyroid gland development GO:0030878 9.23 TG PAX8 NKX2-1 BRAF

Molecular functions related to Follicular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 thyroid-stimulating hormone receptor activity GO:0004996 8.92 TSHR PAX8

Sources for Follicular Adenoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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