MCID: FLL031
MIFTS: 39

Follicular Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Follicular Adenoma

MalaCards integrated aliases for Follicular Adenoma:

Name: Follicular Adenoma 12 15 71
Follicular Adenoma of the Thyroid Gland 12
Thyroid Gland Follicular Adenoma 71
Thyroid Follicular Adenoma 12
Follicular Thyroid Adenoma 17
Adenoma Follicular 54

Classifications:



External Ids:

Disease Ontology 12 DOID:6204
MeSH 43 D000236
SNOMED-CT 67 55021007
UMLS 71 C0151468 C0205647

Summaries for Follicular Adenoma

MalaCards based summary : Follicular Adenoma, also known as follicular adenoma of the thyroid gland, is related to atypical follicular adenoma and adenoma. An important gene associated with Follicular Adenoma is LGALS3 (Galectin 3), and among its related pathways/superpathways are Endometrial cancer and Aldosterone synthesis and secretion. Affiliated tissues include thyroid, bone and testes, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Follicular Adenoma

Diseases related to Follicular Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 atypical follicular adenoma 34.3 TG RET PAX8 CALCA
2 adenoma 31.6 TSHR TG RET LGALS3 BRAF
3 colloid adenoma 30.8 TG LGALS3
4 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.7 TSHR TPO TG
5 fetal adenoma 30.7 TG CALCA
6 parathyroid adenoma 30.7 RET LGALS3 CALCA
7 clear cell adenoma 30.7 TG PAX8
8 thyroid tumor 30.5 TPO TG RET PTEN LGALS3 BRAF
9 thyroid carcinoma 30.4 TSHR TPO TG RET PTEN NKX2-1
10 nontoxic goiter 30.4 TSHR TPO TG CALCA
11 paraganglioma 30.3 TG RET CALCA
12 small cell carcinoma 30.3 PTEN NKX2-1 KRT19 CALCA
13 neuroendocrine tumor 30.2 RET NKX2-1 KRT19 CALCA
14 hyperthyroidism 30.1 TSHR TPO TG CALCA
15 graves' disease 30.0 TSHR TPO TG PAX8
16 thyroiditis 29.9 TSHR TPO TG SLC26A4 RET NKX2-1
17 goiter 29.8 TSHR TPO TG SLC26A4 RET PAX8
18 nodular goiter 29.8 TSHR TPO TG RET LGALS3 KRT19
19 colon adenocarcinoma 29.8 S100A4 PTEN PPARG LGALS3 DPP4 BRAF
20 adenocarcinoma 29.7 RET PTEN NKX2-1 MET BRAF
21 thyroid cancer, nonmedullary, 2 29.6 TSHR TG TFF3 PTEN PPARG PAX8
22 multinodular goiter 29.6 TSHR TPO TG SLC26A4 RET PAX8
23 lung cancer susceptibility 3 29.3 S100A4 RET PTEN NKX2-1 MET KRT19
24 renal cell carcinoma, nonpapillary 29.3 RET PTEN PAX8 NKX2-1 MET KRT19
25 papillary carcinoma 29.2 TSHR TPO TG RET PPARG PAX8
26 hypothyroidism 29.2 TSHR TPO TG SLC26A4 RET PAX8
27 thyroid gland disease 28.9 TSHR TPO TG SLC26A4 RET PPARG
28 differentiated thyroid carcinoma 28.7 TSHR TPO TG RET PPARG PAX8
29 thyroid gland cancer 27.7 TSHR TPO TG SLC26A4 SERPINB5 S100A4
30 thyroid gland anaplastic carcinoma 27.4 TSHR TPO TG SLC26A4 S100A4 RET
31 thyroid cancer, nonmedullary, 4 11.5
32 oncocytoma 11.3
33 multicentric papillary thyroid carcinoma 10.6 TG RET
34 thyroid gland mucoepidermoid carcinoma 10.6 TG CALCA
35 mechanical strabismus 10.6 TPO TG
36 spindle epithelial tumor with thymus-like differentiation tumor 10.6 TG CALCA
37 familial thyroid dyshormonogenesis 10.6 TPO TG
38 substernal goiter 10.6 TG CALCA
39 multiple mucosal neuroma 10.5 RET CALCA
40 skin lipoma 10.5 RET PTEN
41 benign struma ovarii 10.5 TG RET KRT19
42 goiter, multinodular 1, with or without sertoli-leydig cell tumors 10.5 TPO TG
43 postsurgical hypothyroidism 10.5 TPO TG RET
44 isthmus cancer 10.5 TG LGALS3 CALCA
45 transient congenital hypothyroidism 10.5 TSHR TPO
46 ureter small cell carcinoma 10.5 NKX2-1 CALCA
47 cervix endometriosis 10.5 MCM7 MCM2
48 epithelial malignant thymoma 10.5 TG CALCA
49 ovarian germ cell cancer 10.5 TG NKX2-1 KRT19
50 hashimoto encephalopathy 10.5 TSHR TPO

Graphical network of the top 20 diseases related to Follicular Adenoma:



Diseases related to Follicular Adenoma

Symptoms & Phenotypes for Follicular Adenoma

GenomeRNAi Phenotypes related to Follicular Adenoma according to GeneCards Suite gene sharing:

26 (show all 12)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-1 9.75 BRAF
2 Decreased viability GR00055-A-2 9.75 BRAF
3 Decreased viability GR00221-A-1 9.75 PPARG RET
4 Decreased viability GR00221-A-2 9.75 PPARG RET
5 Decreased viability GR00221-A-3 9.75 PPARG
6 Decreased viability GR00221-A-4 9.75 BRAF PPARG RET
7 Decreased viability GR00240-S-1 9.75 LGALS3 PAX8 TG
8 Decreased viability GR00249-S 9.75 BRAF SERPINB5
9 Decreased viability GR00301-A 9.75 BRAF RET
10 Decreased viability GR00381-A-1 9.75 BRAF CALCA MCM2 SERPINB5
11 Decreased viability GR00386-A-1 9.75 PPARG PTEN SERPINB5
12 Decreased viability GR00402-S-2 9.75 KRT19 PAX8 RET

MGI Mouse Phenotypes related to Follicular Adenoma:

45 (show all 22)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.45 BRAF DPP4 KRT19 LGALS3 MCM2 MCM7
2 behavior/neurological MP:0005386 10.44 BRAF LGALS3 MCM2 MET NKX2-1 PAX8
3 cellular MP:0005384 10.43 BRAF KRT19 LGALS3 MCM2 MCM7 MET
4 endocrine/exocrine gland MP:0005379 10.4 BRAF DPP4 KRT19 MCM2 MET NKX2-1
5 immune system MP:0005387 10.37 BRAF DPP4 KRT19 LGALS3 MCM2 MET
6 homeostasis/metabolism MP:0005376 10.36 BRAF DPP4 LGALS3 MET NKX2-1 PAX8
7 mortality/aging MP:0010768 10.36 BRAF DPP4 KRT19 LGALS3 MCM2 MCM7
8 hematopoietic system MP:0005397 10.34 BRAF DPP4 LGALS3 MCM2 MCM7 PPARG
9 digestive/alimentary MP:0005381 10.32 BRAF KRT19 LGALS3 MCM2 MET NKX2-1
10 cardiovascular system MP:0005385 10.29 BRAF DPP4 KRT19 LGALS3 MET NKX2-1
11 embryo MP:0005380 10.22 BRAF KRT19 MCM2 MET PAX8 PPARG
12 nervous system MP:0003631 10.22 BRAF KRT19 LGALS3 MCM2 MET NKX2-1
13 neoplasm MP:0002006 10.17 BRAF KRT19 LGALS3 MCM2 MET NKX2-1
14 adipose tissue MP:0005375 10.15 BRAF LGALS3 MCM2 PPARG PTEN SERPINB5
15 limbs/digits/tail MP:0005371 10.08 BRAF MET PAX8 PTEN RET TG
16 normal MP:0002873 10.06 BRAF KRT19 MCM2 MET NKX2-1 PAX8
17 hearing/vestibular/ear MP:0005377 10.01 BRAF PAX8 PPARG SLC26A4 TPO TSHR
18 no phenotypic analysis MP:0003012 9.91 KRT19 MET NKX2-1 PAX8 PPARG RET
19 reproductive system MP:0005389 9.9 BRAF KRT19 LGALS3 NKX2-1 PAX8 PPARG
20 renal/urinary system MP:0005367 9.86 BRAF LGALS3 MET PAX8 PPARG PTEN
21 respiratory system MP:0005388 9.61 BRAF DPP4 KRT19 LGALS3 MCM2 MET
22 skeleton MP:0005390 9.36 BRAF KRT19 LGALS3 NKX2-1 PAX8 PPARG

Drugs & Therapeutics for Follicular Adenoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Diagnostic Evaluation of Thyroid Nodules Not yet recruiting NCT03884140

Search NIH Clinical Center for Follicular Adenoma

Genetic Tests for Follicular Adenoma

Anatomical Context for Follicular Adenoma

MalaCards organs/tissues related to Follicular Adenoma:

40
Thyroid, Bone, Testes, Lung, Endothelial, Lymph Node, Brain

Publications for Follicular Adenoma

Articles related to Follicular Adenoma:

(show top 50) (show all 1158)
# Title Authors PMID Year
1
Impact of proto-oncogene mutation detection in cytological specimens from thyroid nodules improves the diagnostic accuracy of cytology. 61 54
20130073 2010
2
BRAF mutation in solid cell nest hyperplasia associated with papillary thyroid carcinoma. A precursor lesion? 61 54
19269016 2009
3
Trefoil factor 3 immunohistochemical characterization of follicular thyroid lesions from tissue microarray. 54 61
19528408 2009
4
Immunohistochemical analysis of nm23 protein expression in thyroid papillary carcinoma and follicular neoplasm. 61 54
18996649 2009
5
Differential expression of CK 19 in follicular adenoma, well-differentiated tumour of uncertain malignant potential (WDT-UMP) and follicular variant of papillary carcinoma. 61 54
19213370 2009
6
TFF3-based candidate gene discrimination of benign and malignant thyroid tumors in a region with borderline iodine deficiency. 54 61
18198227 2008
7
Galectin-3 and CD44v6 positivity by RT-PCR method in fine needle aspirates of benign thyroid lesions. 54 61
17397496 2007
8
Diagnostic usefulness of HBME1, galectin-3, CK19, and CITED1 and evaluation of their expression in encapsulated lesions with questionable features of papillary thyroid carcinoma. 61 54
17050067 2006
9
Differential expression of the components of the plasminogen activating system in human thyroid tumour derived cell lines and papillary carcinomas. 54 61
16928445 2006
10
Cell proliferation marker MCM2, but not Ki67, is helpful for distinguishing between minimally invasive follicular carcinoma and follicular adenoma of the thyroid. 54 61
16722928 2006
11
The efficacy of the thyroid peroxidase marker for distinguishing follicular thyroid carcinoma from follicular adenoma. 54 61
16614712 2006
12
Immunohistochemical separation of follicular variant of papillary thyroid carcinoma from follicular adenoma. 54 61
17308358 2006
13
RET and p53 expression in thyroid follicular adenoma: a study of 52 cases with 14 years follow-up. 61 54
17191391 2005
14
Decreased type 1 iodothyronine deiodinase expression might be an early and discrete event in thyroid cell dedifferentation towards papillary carcinoma. 61 54
15943828 2005
15
Type and prevalence of BRAF mutations are closely associated with papillary thyroid carcinoma histotype and patients' age but not with tumour aggressiveness. 54 61
15902486 2005
16
Benign Hürthle cell adenoma with papillary architecture: a benign lesion mimicking oncocytic papillary carcinoma. 54 61
15735853 2005
17
Immunostaining of galectin-3 and CD44v6 using fine-needle aspiration for distinguishing follicular carcinoma from adenoma. 54 61
15540177 2004
18
Galectin-3 does not reliably distinguish benign from malignant thyroid neoplasms. 61 54
15500653 2004
19
Increased expression of focal adhesion kinase in thyroid cancer: immunohistochemical study. 61 54
15483349 2004
20
Immunohistochemical localisation of RET and p53 mutant protein of thyroid lesions in a North-Eastern Malaysian population and its prognostic implications. 61 54
15203751 2004
21
High-throughput differential screening of mRNAs by serial analysis of gene expression: decreased expression of trefoil factor 3 mRNA in thyroid follicular carcinomas. 61 54
15083192 2004
22
S100A4 expression is an early event of papillary carcinoma of the thyroid. 61 54
15713996 2004
23
Diagnostic applicability of dipeptidyl aminopeptidase IV activity in cytological samples for differentiating follicular thyroid carcinoma from follicular adenoma. 54 61
14718282 2004
24
Cytokeratin subtypes in thyroid tumours: immunohistochemical study with emphasis on the follicular variant of papillary carcinoma. 54 61
14974863 2003
25
High prevalence of BRAF gene mutation in papillary thyroid carcinomas and thyroid tumor cell lines. 54 61
12907632 2003
26
Peroxisome proliferator-activated receptor gamma expression in follicular-patterned thyroid lesions. Caveats for the use of immunohistochemical studies. 61 54
12931546 2003
27
BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC. 54 61
12881714 2003
28
Expression of RET in follicular cell-derived tumors of the thyroid gland: prevalence and implication of morphological type. 54 61
12608895 2003
29
Usefulness of galectin-3 immunohistochemistry in differential diagnosis between thyroid follicular carcinoma and follicular adenoma. 61 54
14575419 2003
30
Galectin-3 messenger ribonucleic acid and protein are expressed in benign thyroid tumors. 61 54
12364477 2002
31
Galectin-3 is not an universal marker of malignancy in thyroid nodular disease in children and adolescents. 61 54
12213909 2002
32
Characterization and semiquantitative analyses of pendrin expressed in normal and tumoral human thyroid tissues. 61 54
11932304 2002
33
uPA receptor expression in benign and malignant thyroid tumors. 61 54
12017319 2002
34
Diagnostic utility of cytokeratin 19 expression in multinodular goiter with papillary areas and papillary carcinoma of thyroid. 54 61
12446919 2002
35
Cytokeratin 19 immunoreactivity in the diagnosis of papillary thyroid carcinoma: a note of caution. 61 54
11710686 2001
36
Galectin-3 as a presurgical immunocytodiagnostic marker of minimally invasive follicular thyroid carcinoma. 61 54
11701669 2001
37
Follicular adenoma with papillary architecture: a lesion mimicking papillary thyroid carcinoma. 54 61
11454041 2001
38
Ret oncogene protein expression in papillary thyroid carcinoma and related lesions. 61 54
11504372 2001
39
Clinical significance of E-cadherin expression in thyroid neoplasms. 54 61
11276021 2001
40
Differential reactivity for galectin-3 in Hürthle cell adenomas and carcinomas. 54 61
11740048 2001
41
Fine-needle aspiration biopsy of papillary thyroid carcinoma: diagnostic utility of cytokeratin 19 immunostaining. 61 54
11038428 2000
42
Expression of the cadherin-catenin complex in well-differentiated human thyroid neoplastic tissue. 54 61
10595458 1999
43
Role of serum thyroglobulin in the pre-operative evaluation of follicular thyroid tumours. 61 54
9870733 1998
44
The role of cell cycle regulatory proteins, cyclin D1, cyclin E, and p27 in thyroid carcinogenesis. 54 61
9824112 1998
45
c-Met expression of thyroid tissue with special reference to papillary carcinoma. 54 61
9788259 1998
46
Ret oncogene activation in papillary thyroid carcinoma: prevalence and implication on the histological parameters. 54 61
9635675 1998
47
Expression of splice variants of CD44 in thyroid neoplasms derived from follicular cells. 54 61
9589486 1998
48
Integrins in thyroid tissue: upregulation of alpha2beta1 in anaplastic thyroid carcinoma. 61 54
9461325 1998
49
Thyroid paraganglioma: a clinicopathologic and immunohistochemical study of three cases. 61 54
9236830 1997
50
G protein and thyrotropin receptor mutations in thyroid neoplasia. 61 54
9024242 1997

Variations for Follicular Adenoma

Expression for Follicular Adenoma

Search GEO for disease gene expression data for Follicular Adenoma.

Pathways for Follicular Adenoma

GO Terms for Follicular Adenoma

Cellular components related to Follicular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 TG TFF3 SERPINB5 S100A4 PTEN MET
2 MCM complex GO:0042555 8.62 MCM7 MCM2

Biological processes related to Follicular Adenoma according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 thyroid hormone generation GO:0006590 9.49 TPO TG
2 DNA unwinding involved in DNA replication GO:0006268 9.48 MCM7 MCM2
3 hormone biosynthetic process GO:0042446 9.46 TPO TG
4 double-strand break repair via break-induced replication GO:0000727 9.43 MCM7 MCM2
5 cellular response to nerve growth factor stimulus GO:1990090 9.43 PTEN CALCA BRAF
6 pre-replicative complex assembly involved in nuclear cell cycle DNA replication GO:0006267 9.4 MCM7 MCM2
7 regulation of axon regeneration GO:0048679 9.37 PTEN BRAF
8 endothelial cell migration GO:0043542 9.33 PTEN DPP4 CALCA
9 iodide transport GO:0015705 9.32 TG SLC26A4
10 thyroid-stimulating hormone signaling pathway GO:0038194 8.96 TSHR PAX8
11 thyroid gland development GO:0030878 8.92 TG PAX8 NKX2-1 BRAF

Molecular functions related to Follicular Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.11 TSHR TG TFF3 SERPINB5 S100A4 RET
2 identical protein binding GO:0042802 9.56 TG S100A4 PTEN PPARG MET DPP4
3 protein phosphatase binding GO:0019903 9.43 PPARG MET LGALS3
4 thyroid-stimulating hormone receptor activity GO:0004996 8.62 TSHR PAX8

Sources for Follicular Adenoma

3 CDC
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9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
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30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
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44 MESH via Orphanet
45 MGI
48 NCI
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50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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