FL1
MCID: FLL041
MIFTS: 49

Follicular Lymphoma 1 (FL1)

Categories: Blood diseases, Cancer diseases, Immune diseases, Rare diseases

Aliases & Classifications for Follicular Lymphoma 1

MalaCards integrated aliases for Follicular Lymphoma 1:

Name: Follicular Lymphoma 1 57 29
Follicular Lymphoma, Susceptibility to, 1 57 13
Lymphoma, Follicular, Type 1 40
Lymphoma, Follicular 73
Follicular Lymphoma 59
Fl1 57

Characteristics:

Orphanet epidemiological data:

59
follicular lymphoma
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-5/10000 (Europe),1-9/100000 (France); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

OMIM 57 613024
Orphanet 59 ORPHA545
UMLS via Orphanet 74 C0024301
MESH via Orphanet 45 D008224
MedGen 42 C2751665
UMLS 73 C0024301

Summaries for Follicular Lymphoma 1

OMIM : 57 Follicular non-Hodgkin lymphoma is an indolent B-cell malignancy with an annual incidence exceeding 10,000 cases in the United States (Bohen et al., 2003). One form of susceptibility to follicular lymphoma (FL1) is associated with a region on chromosome 6p21.33. (613024)

MalaCards based summary : Follicular Lymphoma 1, also known as follicular lymphoma, susceptibility to, 1, is related to lymphoma and mantle cell lymphoma. An important gene associated with Follicular Lymphoma 1 is BCL10 (BCL10, Immune Signaling Adaptor), and among its related pathways/superpathways are Immune response NFAT in immune response and Direct p53 effectors. The drugs Arzerra and Zevalin have been mentioned in the context of this disorder. Affiliated tissues include b cells, t cells and bone, and related phenotypes are lymphoma and splenomegaly

Related Diseases for Follicular Lymphoma 1

Diseases in the Follicular Lymphoma family:

Follicular Lymphoma 1

Diseases related to Follicular Lymphoma 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 183)
# Related Disease Score Top Affiliating Genes
1 lymphoma 31.7 BCL10 BCL2 BCL6
2 mantle cell lymphoma 31.0 BCL2 BCL6 IGH
3 follicular lymphoma 30.9 BCL10 BCL2 BCL6 FL1 IGH
4 nodal marginal zone b-cell lymphoma 30.9 BCL2 BCL6
5 primary central nervous system lymphoma 30.8 BCL2 BCL6
6 b-cell lymphomas 30.6 BCL10 BCL2 BCL6
7 t-cell/histiocyte rich large b cell lymphoma 30.3 BCL6 IGH
8 intravascular large b-cell lymphoma 30.2 BCL2 BCL6
9 primary mediastinal large b-cell lymphoma 30.2 BCL2 BCL6
10 marginal zone b-cell lymphoma 30.0 BCL10 BCL2 BCL6
11 leukemia, chronic lymphocytic 29.9 BCL10 BCL2 BCL6 IGH
12 lymphoma, mucosa-associated lymphoid type 29.7 BCL10 BCL2 BCL6 IGH
13 lymphoma, non-hodgkin, familial 29.6 BCL10 BCL2 BCL6 IGH
14 precursor t-cell acute lymphoblastic leukemia 29.4 BCL10 IGH
15 primary cutaneous follicle center lymphoma 11.5
16 histiocytic and dendritic cell cancer 11.1
17 diffuse large b-cell lymphoma 11.0
18 burkitt lymphoma 10.8
19 primary effusion lymphoma 10.8
20 lymphoblastic lymphoma 10.7
21 plasmablastic lymphoma 10.7
22 lymphocytic leukemia 10.4
23 lymphomatoid granulomatosis 10.4
24 leukemia 10.3
25 leukemia, chronic lymphocytic 2 10.3
26 leukemia, b-cell, chronic 10.3
27 sarcoma 10.3
28 hematopoietic stem cell transplantation 10.2
29 leukemia, acute lymphoblastic 3 10.2
30 splenic marginal zone lymphoma 10.2
31 primary cutaneous diffuse large b-cell lymphoma, leg type 10.2
32 primary cutaneous marginal zone b-cell lymphoma 10.2
33 alk-positive large b-cell lymphoma 10.2
34 epstein-barr virus-positive diffuse large b-cell lymphoma of the elderly 10.2
35 diffuse large b-cell lymphoma of the central nervous system 10.2
36 splenic diffuse red pulp small b-cell lymphoma 10.2
37 diffuse large b-cell lymphoma with chronic inflammation 10.2
38 lymphoplasmacytic lymphoma without igm production 10.2
39 pemphigus 10.2
40 paraneoplastic pemphigus 10.2
41 lymphoma, hodgkin, classic 10.1
42 nodal marginal zone lymphoma 10.1
43 histiocytic sarcoma 10.1
44 leukemia, acute lymphoblastic 10.1
45 hepatitis 10.1
46 adenocarcinoma 10.1
47 progressive multifocal leukoencephalopathy 10.1
48 heparin-induced thrombocytopenia 10.1
49 myeloma, multiple 10.0
50 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 10.0 BCL2 BCL6

Graphical network of the top 20 diseases related to Follicular Lymphoma 1:



Diseases related to Follicular Lymphoma 1

Symptoms & Phenotypes for Follicular Lymphoma 1

Clinical features from OMIM:

613024

Human phenotypes related to Follicular Lymphoma 1:

59 32 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 lymphoma 59 32 Very frequent (99-80%) HP:0002665
2 splenomegaly 59 Frequent (79-30%)
3 fever 59 Very frequent (99-80%)
4 fatigue 59 Frequent (79-30%)
5 weight loss 59 Very frequent (99-80%)
6 lymphedema 59 Occasional (29-5%)
7 meningitis 59 Occasional (29-5%)
8 mediastinal lymphadenopathy 59 Very frequent (99-80%)
9 lymphadenopathy 59 Very frequent (99-80%)
10 abnormality of the peritoneum 59 Occasional (29-5%)
11 pleural effusion 59 Occasional (29-5%)
12 skin nodule 59 Occasional (29-5%)
13 night sweats 59 Very frequent (99-80%)

Drugs & Therapeutics for Follicular Lymphoma 1

FDA approved drugs:

# Drug Name Active Ingredient(s) 18 Company Approval Date
1
Arzerra 18 49 OFATUMUMAB GlaxoSmithKline October 2009
2
Zevalin 18 49 IBRITUMOMAB TIUXETAN Biogen IDEC February 2002

Search Clinical Trials , NIH Clinical Center for Follicular Lymphoma 1

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Follicular Lymphoma 1

Genetic tests related to Follicular Lymphoma 1:

# Genetic test Affiliating Genes
1 Follicular Lymphoma 1 29

Anatomical Context for Follicular Lymphoma 1

MalaCards organs/tissues related to Follicular Lymphoma 1:

41
B Cells, T Cells, Bone, Bone Marrow, Lung, Skin, Breast

Publications for Follicular Lymphoma 1

Articles related to Follicular Lymphoma 1:

# Title Authors Year
1
A rare composite lymphoma: follicular and in situ mantle cell. ( 27103006 )
2016
2
Indolent lymphoma: follicular lymphoma and the microenvironment-insights from the microscope. ( 25696849 )
2014
3
Indolent lymphoma: follicular lymphoma and the microenvironment-insights from gene expression profiling. ( 25696850 )
2014
4
Diffuse large B-cell lymphoma/follicular lymphoma arising in a background of IgG4-related pachymeningitis. ( 24247630 )
2013
5
Clinicopathologic analysis of peripheral T-cell lymphoma, follicular variant, and comparison with angioimmunoblastic T-cell lymphoma: Bcl-6 expression might affect progression between these disorders. ( 22586046 )
2012
6
Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma. ( 18223287 )
2008
7
Lymphomatous polyposis of the gastrointestinal tract, including mantle cell lymphoma, follicular lymphoma and mucosa-associated lymphoid tissue lymphoma. ( 16241994 )
2005
8
Genetic and molecular genetic studies in the diagnosis of B-cell lymphomas I: mantle cell lymphoma, follicular lymphoma, and Burkitt's lymphoma. ( 12733111 )
2003
9
Cutaneous follicle center cell lymphoma, follicular type. ( 11481531 )
2001

Variations for Follicular Lymphoma 1

ClinVar genetic disease variations for Follicular Lymphoma 1:

6 (show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 BCL10 NM_003921.4(BCL10): c.427_428dupTT (p.Glu145Leufs) duplication Pathogenic rs587776632 GRCh37 Chromosome 1, 85733584: 85733585
2 BCL10 NM_003921.4(BCL10): c.427_428dupTT (p.Glu145Leufs) duplication Pathogenic rs587776632 GRCh38 Chromosome 1, 85267901: 85267902
3 BCL10 NM_003921.4(BCL10): c.231dupA (p.Gly78Argfs) duplication Pathogenic rs587776633 GRCh37 Chromosome 1, 85736416: 85736416
4 BCL10 NM_003921.4(BCL10): c.231dupA (p.Gly78Argfs) duplication Pathogenic rs587776633 GRCh38 Chromosome 1, 85270733: 85270733
5 BCL10 NM_003921.4(BCL10): c.525_541del17 (p.Val176Asnfs) deletion Pathogenic rs587776634 GRCh37 Chromosome 1, 85733471: 85733487
6 BCL10 NM_003921.4(BCL10): c.525_541del17 (p.Val176Asnfs) deletion Pathogenic rs587776634 GRCh38 Chromosome 1, 85267788: 85267804
7 BCL10 NM_003921.4(BCL10): c.410delA (p.Asn137Ilefs) deletion Pathogenic rs587776635 GRCh37 Chromosome 1, 85733602: 85733602
8 BCL10 NM_003921.4(BCL10): c.410delA (p.Asn137Ilefs) deletion Pathogenic rs587776635 GRCh38 Chromosome 1, 85267919: 85267919
9 BCL10 NM_003921.4(BCL10): c.398dupT (p.Ser134Leufs) duplication Pathogenic rs587776636 GRCh37 Chromosome 1, 85733614: 85733614
10 BCL10 NM_003921.4(BCL10): c.398dupT (p.Ser134Leufs) duplication Pathogenic rs587776636 GRCh38 Chromosome 1, 85267931: 85267931
11 BCL10 NM_003921.4(BCL10): c.635_637delAAG (p.Glu212del) deletion Pathogenic rs587776637 GRCh37 Chromosome 1, 85733375: 85733377
12 BCL10 NM_003921.4(BCL10): c.635_637delAAG (p.Glu212del) deletion Pathogenic rs587776637 GRCh38 Chromosome 1, 85267692: 85267694

Expression for Follicular Lymphoma 1

Search GEO for disease gene expression data for Follicular Lymphoma 1.

Pathways for Follicular Lymphoma 1

GO Terms for Follicular Lymphoma 1

Biological processes related to Follicular Lymphoma 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.5 BCL10 BCL6 HLA-DRB1
2 T cell receptor signaling pathway GO:0050852 9.4 BCL10 HLA-DRB1
3 negative regulation of cell growth GO:0030308 9.37 BCL2 BCL6
4 B cell differentiation GO:0030183 9.26 BCL2 BCL6
5 cell morphogenesis GO:0000902 9.16 BCL2 BCL6
6 positive regulation of B cell proliferation GO:0030890 8.96 BCL2 BCL6
7 regulation of apoptotic process GO:0042981 8.8 BCL10 BCL2 BCL6

Molecular functions related to Follicular Lymphoma 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 BCL10 BCL2

Sources for Follicular Lymphoma 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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