MCID: FLL041
MIFTS: 42

Follicular Lymphoma 1

Categories: Blood diseases, Rare diseases, Immune diseases, Cancer diseases

Aliases & Classifications for Follicular Lymphoma 1

MalaCards integrated aliases for Follicular Lymphoma 1:

Name: Follicular Lymphoma 1 57 29
Follicular Lymphoma, Susceptibility to, 1 57 13
Lymphoma, Follicular, Type 1 40
Lymphoma, Follicular 73
Follicular Lymphoma 59
Fl1 57

Characteristics:

Orphanet epidemiological data:

59
follicular lymphoma
Inheritance: Multigenic/multifactorial,Not applicable; Prevalence: 1-5/10000 (Europe),1-9/100000 (France); Age of onset: Adult; Age of death: adult;

Classifications:



External Ids:

OMIM 57 613024
Orphanet 59 ORPHA545
UMLS via Orphanet 74 C0024301
MESH via Orphanet 45 D008224
MedGen 42 C2751665
UMLS 73 C0024301

Summaries for Follicular Lymphoma 1

OMIM : 57 Follicular non-Hodgkin lymphoma is an indolent B-cell malignancy with an annual incidence exceeding 10,000 cases in the United States (Bohen et al., 2003). One form of susceptibility to follicular lymphoma (FL1) is associated with a region on chromosome 6p21.33. (613024)

MalaCards based summary : Follicular Lymphoma 1, also known as follicular lymphoma, susceptibility to, 1, is related to follicular lymphoma and t-cell/histiocyte rich large b cell lymphoma. An important gene associated with Follicular Lymphoma 1 is BCL10 (B Cell CLL/Lymphoma 10), and among its related pathways/superpathways are Immune response Antigen presentation by MHC class II and Direct p53 effectors. The drugs Cisplatin and Gemcitabine have been mentioned in the context of this disorder. Affiliated tissues include b cells, skin and pancreas, and related phenotypes are lymphoma and lymphedema

Related Diseases for Follicular Lymphoma 1

Graphical network of the top 20 diseases related to Follicular Lymphoma 1:



Diseases related to Follicular Lymphoma 1

Symptoms & Phenotypes for Follicular Lymphoma 1

Clinical features from OMIM:

613024

Human phenotypes related to Follicular Lymphoma 1:

59 32 (show all 13)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 lymphoma 59 32 Very frequent (99-80%) HP:0002665
2 lymphedema 59 Occasional (29-5%)
3 meningitis 59 Occasional (29-5%)
4 splenomegaly 59 Frequent (79-30%)
5 weight loss 59 Very frequent (99-80%)
6 fever 59 Very frequent (99-80%)
7 pleural effusion 59 Occasional (29-5%)
8 abnormality of the peritoneum 59 Occasional (29-5%)
9 lymphadenopathy 59 Very frequent (99-80%)
10 fatigue 59 Frequent (79-30%)
11 night sweats 59 Very frequent (99-80%)
12 mediastinal lymphadenopathy 59 Very frequent (99-80%)
13 skin nodule 59 Occasional (29-5%)

Drugs & Therapeutics for Follicular Lymphoma 1

Drugs for Follicular Lymphoma 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 2 15663-27-1 84093 441203 2767
2
Gemcitabine Approved Phase 2 95058-81-4 60750
3
Pancrelipase Approved, Investigational Phase 2 53608-75-6
4
Sorafenib Approved, Investigational Phase 2 284461-73-0 216239 406563
5
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2 59-30-3 6037
6
Niacin Approved, Investigational, Nutraceutical Phase 2 59-67-6 938
7
Nicotinamide Approved, Investigational, Nutraceutical Phase 2 98-92-0 936
8 Antibodies Phase 2
9 Antibodies, Monoclonal Phase 2
10 Immunoglobulins Phase 2
11 Anti-Infective Agents Phase 2
12 Antimetabolites Phase 2
13 Antimetabolites, Antineoplastic Phase 2
14 Antiviral Agents Phase 2
15 Immunosuppressive Agents Phase 2
16 Micronutrients Phase 2
17 Nicotinic Acids Phase 2
18 pancreatin Phase 2
19 Protein Kinase Inhibitors Phase 2
20 Trace Elements Phase 2
21 Vitamin B Complex Phase 2
22 Vitamins Phase 2
23 Folate Nutraceutical Phase 2
24 Vitamin B3 Nutraceutical Phase 2
25 Vitamin B9 Nutraceutical Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Comparison of RPDs Retained by Conical and Galvanoformed Double Crowns. Unknown status NCT00176215 Phase 4
2 Consolidation Treatment With Y90-Ibritumomab Tiuxetan After R-CHOP Induction in High Risk Patients According to Follicular Lymphoma International Prognostic Index (FLIPI) With Follicular Lymphoma Unknown status NCT00722930 Phase 2 Y90 Ibritumomab Tiuxetan
3 Metastatic Advanced Pancreas Sorafenib Unknown status NCT00758381 Phase 2 Sorafenib 400 mg po bid, continuously;Gemcitabina, Cisplatino

Search NIH Clinical Center for Follicular Lymphoma 1

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Genetic Tests for Follicular Lymphoma 1

Genetic tests related to Follicular Lymphoma 1:

# Genetic test Affiliating Genes
1 Follicular Lymphoma 1 29 BCL10

Anatomical Context for Follicular Lymphoma 1

MalaCards organs/tissues related to Follicular Lymphoma 1:

41
B Cells, Skin, Pancreas, T Cells

Publications for Follicular Lymphoma 1

Articles related to Follicular Lymphoma 1:

# Title Authors Year
1
A rare composite lymphoma: follicular and in situ mantle cell. ( 27103006 )
2016
2
Diffuse large B-cell lymphoma/follicular lymphoma arising in a background of IgG4-related pachymeningitis. ( 24247630 )
2013
3
Clinicopathologic analysis of peripheral T-cell lymphoma, follicular variant, and comparison with angioimmunoblastic T-cell lymphoma: Bcl-6 expression might affect progression between these disorders. ( 22586046 )
2012
4
Genetic and molecular genetic studies in the diagnosis of B-cell lymphomas I: mantle cell lymphoma, follicular lymphoma, and Burkitt's lymphoma. ( 12733111 )
2003

Variations for Follicular Lymphoma 1

ClinVar genetic disease variations for Follicular Lymphoma 1:

6
(show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 BCL10 NM_003921.4(BCL10): c.427_428dupTT (p.Glu145Leufs) duplication Pathogenic rs587776632 GRCh37 Chromosome 1, 85733584: 85733585
2 BCL10 NM_003921.4(BCL10): c.427_428dupTT (p.Glu145Leufs) duplication Pathogenic rs587776632 GRCh38 Chromosome 1, 85267901: 85267902
3 BCL10 NM_003921.4(BCL10): c.231dupA (p.Gly78Argfs) duplication Pathogenic rs587776633 GRCh37 Chromosome 1, 85736416: 85736416
4 BCL10 NM_003921.4(BCL10): c.231dupA (p.Gly78Argfs) duplication Pathogenic rs587776633 GRCh38 Chromosome 1, 85270733: 85270733
5 BCL10 NM_003921.4(BCL10): c.525_541del17 (p.Val176Asnfs) deletion Pathogenic rs587776634 GRCh37 Chromosome 1, 85733471: 85733487
6 BCL10 NM_003921.4(BCL10): c.525_541del17 (p.Val176Asnfs) deletion Pathogenic rs587776634 GRCh38 Chromosome 1, 85267788: 85267804
7 BCL10 NM_003921.4(BCL10): c.410delA (p.Asn137Ilefs) deletion Pathogenic rs587776635 GRCh37 Chromosome 1, 85733602: 85733602
8 BCL10 NM_003921.4(BCL10): c.410delA (p.Asn137Ilefs) deletion Pathogenic rs587776635 GRCh38 Chromosome 1, 85267919: 85267919
9 BCL10 NM_003921.4(BCL10): c.398dupT (p.Ser134Leufs) duplication Pathogenic rs587776636 GRCh37 Chromosome 1, 85733614: 85733614
10 BCL10 NM_003921.4(BCL10): c.398dupT (p.Ser134Leufs) duplication Pathogenic rs587776636 GRCh38 Chromosome 1, 85267931: 85267931
11 BCL10 NM_003921.4(BCL10): c.635_637delAAG (p.Glu212del) deletion Pathogenic rs587776637 GRCh37 Chromosome 1, 85733375: 85733377
12 BCL10 NM_003921.4(BCL10): c.635_637delAAG (p.Glu212del) deletion Pathogenic rs587776637 GRCh38 Chromosome 1, 85267692: 85267694

Expression for Follicular Lymphoma 1

Search GEO for disease gene expression data for Follicular Lymphoma 1.

Pathways for Follicular Lymphoma 1

GO Terms for Follicular Lymphoma 1

Biological processes related to Follicular Lymphoma 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.43 BCL10 BCL6 HLA-DRB1
2 negative regulation of cell growth GO:0030308 9.37 BCL2 BCL6
3 cell morphogenesis GO:0000902 9.32 BCL2 BCL6
4 B cell differentiation GO:0030183 9.16 BCL2 BCL6
5 regulation of apoptotic process GO:0042981 9.13 BCL10 BCL2 BCL6
6 positive regulation of B cell proliferation GO:0030890 8.62 BCL2 BCL6

Molecular functions related to Follicular Lymphoma 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protease binding GO:0002020 8.62 BCL10 BCL2

Sources for Follicular Lymphoma 1

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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