MCID: FLL042
MIFTS: 28

Folliculotropic Mycosis Fungoides

Categories: Blood diseases, Rare diseases, Skin diseases

Aliases & Classifications for Folliculotropic Mycosis Fungoides

MalaCards integrated aliases for Folliculotropic Mycosis Fungoides:

Name: Folliculotropic Mycosis Fungoides 58
Mycosis Fungoides-Associated Follicular Mucinosis 58
Follicular Mycosis Fungoides 70

Characteristics:

Orphanet epidemiological data:

58
folliculotropic mycosis fungoides
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 58  
Rare skin diseases
Rare haematological diseases


External Ids:

ICD10 via Orphanet 33 C84.0
UMLS via Orphanet 71 C1627767
Orphanet 58 ORPHA178512
UMLS 70 C1627767

Summaries for Folliculotropic Mycosis Fungoides

MalaCards based summary : Folliculotropic Mycosis Fungoides, also known as mycosis fungoides-associated follicular mucinosis, is related to mycosis fungoides and dermatitis, atopic. An important gene associated with Folliculotropic Mycosis Fungoides is CCR3 (C-C Motif Chemokine Receptor 3), and among its related pathways/superpathways are CCR5 Pathway in Macrophages and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. The drugs Lenalidomide and Durvalumab have been mentioned in the context of this disorder. Affiliated tissues include t cells and bone marrow.

Related Diseases for Folliculotropic Mycosis Fungoides

Diseases related to Folliculotropic Mycosis Fungoides via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 54)
# Related Disease Score Top Affiliating Genes
1 mycosis fungoides 31.4 CXCR3 CCR3
2 dermatitis, atopic 29.9 CXCR3 CCR3
3 contact dermatitis 29.9 CXCR3 CCR3
4 allergic contact dermatitis 29.8 CXCR3 CCR3
5 immune deficiency disease 29.4 CXCR3 CCR3
6 cutaneous t cell lymphoma 10.8
7 alopecia 10.8
8 follicular mucinosis 10.6
9 lymphoma 10.5
10 keratosis 10.4
11 alopecia areata 10.4
12 lymphoproliferative syndrome 10.3
13 hidradenitis suppurativa 10.3
14 hidradenitis 10.3
15 dermatitis 10.3
16 folliculitis 10.3
17 hypereosinophilic syndrome 10.3
18 granulomatous slack skin disease 10.3
19 primary cutaneous t-cell lymphoma 10.3
20 lymphoma, hodgkin, classic 10.2
21 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
22 hyper-ige recurrent infection syndrome 2, autosomal recessive 10.2
23 perifolliculitis capitis abscedens et suffodiens, familial 10.2
24 langerhans cell histiocytosis 10.2
25 lymphoma, non-hodgkin, familial 10.2
26 exanthem 10.2
27 rapidly involuting congenital hemangioma 10.2
28 anhidrosis 10.2
29 neutropenia 10.2
30 toxic shock syndrome 10.2
31 candidiasis 10.2
32 fungal infectious disease 10.2
33 vascular disease 10.2
34 autoimmune hepatitis 10.2
35 hepatitis 10.2
36 histiocytosis 10.2
37 cellulitis 10.2
38 tinea capitis 10.2
39 acne 10.2
40 molluscum contagiosum 10.2
41 rosacea 10.2
42 dermatophytosis 10.2
43 eosinophilic pustular folliculitis 10.2
44 frontal fibrosing alopecia 10.2
45 post-transplant lymphoproliferative disease 10.2
46 dock8 immunodeficiency syndrome 10.2
47 orofacial granulomatosis 9.8 CXCR3 CCR3
48 secondary progressive multiple sclerosis 9.8 CXCR3 CCR3
49 multiple sclerosis 9.8 CXCR3 CCR3
50 human immunodeficiency virus infectious disease 9.7 CXCR3 CCR3

Graphical network of the top 20 diseases related to Folliculotropic Mycosis Fungoides:



Diseases related to Folliculotropic Mycosis Fungoides

Symptoms & Phenotypes for Folliculotropic Mycosis Fungoides

Drugs & Therapeutics for Folliculotropic Mycosis Fungoides

Drugs for Folliculotropic Mycosis Fungoides (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenalidomide Approved Phase 1, Phase 2 191732-72-6 216326
2
Durvalumab Approved, Investigational Phase 1, Phase 2 1428935-60-7
3 Angiogenesis Inhibitors Phase 1, Phase 2
4 Antineoplastic Agents, Immunological Phase 1, Phase 2
5 Immunoglobulins Phase 1, Phase 2
6 Antibodies Phase 1, Phase 2
7 Immunologic Factors Phase 1, Phase 2
8 Immunoglobulin G Phase 1, Phase 2
9 Immunoglobulins, Intravenous Phase 1, Phase 2
10 Antibodies, Monoclonal Phase 1, Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Phase 1/2 Trial of Durvalumab (MEDI4736) When Given as a Single Agent or in Combination With Lenalidomide in Patients With Relapsed/ Refractory Peripheral T-cell Lymphoma, Including Cutaneous T-cell Lymphoma Recruiting NCT03011814 Phase 1, Phase 2 Lenalidomide

Search NIH Clinical Center for Folliculotropic Mycosis Fungoides

Genetic Tests for Folliculotropic Mycosis Fungoides

Anatomical Context for Folliculotropic Mycosis Fungoides

MalaCards organs/tissues related to Folliculotropic Mycosis Fungoides:

40
T Cells, Bone Marrow

Publications for Folliculotropic Mycosis Fungoides

Articles related to Folliculotropic Mycosis Fungoides:

(show top 50) (show all 143)
# Title Authors PMID Year
1
Multiple facial plaques of diffuse plane xanthoma arising from regressed tumours of folliculotropic mycosis fungoides. 61
32686225 2021
2
High incidence of adnexotropism in cytotoxic cutaneous lymphomas. 61
33759218 2021
3
Dermoscopic and trichoscopic features of primary cutaneous lymphomas - systematic review. 61
33710688 2021
4
Acneiform Presentations of Folliculotropic Mycosis Fungoides. 61
33492839 2021
5
Association of a Proposed New Staging System for Folliculotropic Mycosis Fungoides With Prognostic Variables in a US Cohort. 61
33295938 2021
6
Folliculotropic mycosis fungoides clinically resembling allergic contact dermatitis. 61
33598955 2021
7
Favourable outcomes in folliculotropic mycosis fungoides after multimodality treatment in a single institution. 61
32594555 2021
8
Folliculotropic mycosis fungoides driven by DOCK8 immunodeficiency syndrome. 61
33099799 2021
9
Folliculotropic Mycosis Fungoides. 61
33768049 2021
10
Primary cutaneous lymphomas in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL): A series of 12 cases. 61
33415780 2021
11
Unmasking a T cell lymphoma: Folliculotropic mycosis fungoides with a gamma-delta phenotype. 61
32989422 2020
12
Cicatricial Alopecia Related to Folliculotropic Mycosis Fungoides. 61
32833161 2020
13
Value of High-Frequency Ultrasound in Accurate Staging of Mycosis Fungoides/Sézary Syndrome. 61
32319698 2020
14
Dermoscopy of Syringotropic and Folliculotropic Mycosis Fungoides. 61
33150017 2020
15
Stage-dependent Increase in Expression of miR-155 and Ki-67 and Number of Tumour-associated Inflammatory Cells in Folliculotropic Mycosis Fungoides. 61
32556361 2020
16
Folliculotropic mycosis fungoides: Clinical characteristics, treatments, and long-term outcomes of 53 patients in a tertiary hospital. 61
32410323 2020
17
Follicular Eruption With Folliculotropic Lymphocytic Infiltrates Associated With Iatrogenic Immunosuppression: Report and Study of 3 Cases, and Review of the Literature. 61
31789839 2020
18
An Uncommon Case of Lichen Spinulosus in an Adult Patient Clinically Mmimicking Folliculotropic Mycosis Fungoides. 61
32670708 2020
19
Pilot Study of a Novel Therapeutic Approach for Refractory Advanced Stage Folliculotropic Mycosis Fungoides. 61
32128597 2020
20
Another window into tumor microenvironment: a case of Β-cell rich folliculotropic mycosis fungoides responding to rituximab. 61
31944261 2020
21
Demodex-induced follicular mucinosis of the head and neck mimicking folliculotropic mycosis fungoides. 61
32258294 2020
22
Plaque stage folliculotropic mycosis fungoides: histopathologic features and prognostic factors in a series of 40 patients. 61
31755567 2020
23
The different faces of mycosis fungoides: results of a single-center study. 61
31782525 2020
24
A case of folliculotropic mycosis fungoides successfully treated with topical steroid treatment. 61
32362640 2020
25
Revisiting Imiquimod for Treatment of Folliculotropic Mycosis Fungoides: A Case Report and Review of the Literature. 61
31407190 2019
26
Syringotropic Mycosis Fungoides: A Variant of Folliculotropic Mycosis Fungoides or a Distinct Entity? 61
30946094 2019
27
Dermoscopic characterization of folliculotropic mycosis fungoides selectively localized on trunk and limbs. 61
31135956 2019
28
Dermoscopy in folliculotropic mycosis fungoides-A possible mimicker of follicle-based inflammatory and infectious disorders. 61
31078608 2019
29
Reply: Application of dermoscopy in folliculotropic mycosis fungoides. 61
31078610 2019
30
Severe and Lethal Presentation of Folliculotropic Mycosis Fungoides. 61
30642565 2019
31
Cutaneous lymphomas-An update 2019. 61
31187534 2019
32
Folliculotropic mycosis fungoides in a pediatric patient mimicking black dot tinea capitis. 61
30791127 2019
33
Syringotropic and folliculotropic mycosis fungoides with mycosis fungoides-associated vasculopathic ulcers. 61
30834284 2019
34
Generalized Molluscum Contagiosum Successfully Treated with Interferon-Alpha in a Patient with Folliculotropic Mycosis Fungoides. 61
31043940 2019
35
Folliculotropic mycosis fungoides in a pediatric patient with response to psoralen-ultraviolet A phototherapy. 61
30007081 2019
36
[Acrally emphasized papules-a case report]. 61
29955917 2019
37
Folliculotropic mycosis fungoides associated with GATA2 deficiency: a new skin manifestation. 61
30101490 2018
38
Folliculotropic mycosis fungoides. 61
30677794 2018
39
Treatment of Early Folliculotropic Mycosis Fungoides with Special Focus on Psoralen plus Ultraviolet A. 61
30085321 2018
40
Folliculotropic Mycosis Fungoides With CD30+ Large-Cell Transformation. 61
30205898 2018
41
T-cell papulosis associated with B-cell malignancy: a distinctive clinicopathologic entity. 61
29356170 2018
42
Juvenile-Onset Early-Stage Mycosis Fungoides-Associated Follicular Mucinosis: A Case Report. 61
29927752 2018
43
Erratum: Folliculotropic Mycosis Fungoides in 20 Korean Cases: Clinical and Histopathologic Features and Response to Ultraviolet A-1 and/or Photodynamic Therapy. 61
29983489 2018
44
Immune privilege disruption in folliculotropic mycosis fungoides: investigation of major histocompatibility complex antigen expression. 61
29603194 2018
45
Folliculotropic mycosis fungoides. 61
29726638 2018
46
How to Discern Folliculotropic Mycosis Fungoides From Follicular Mucinosis Using a Pediatric Case. 61
29318909 2018
47
Folliculotropic mycosis fungoides associated with atopic dermatitis. 61
28731507 2018
48
Reflectance Confocal Microscopy as New Diagnostic Tool in Folliculotropic Mycosis Fungoides. 61
29765972 2018
49
Successful treatment of relapsed folliculotropic mycosis fungoides with mogamulizumab followed by intensity-modulated radiotherapy. 61
29068082 2018
50
Folliculotropic Mycosis Fungoides in 20 Korean Cases: Clinical and Histopathologic Features and Response to Ultraviolet A-1 and/or Photodynamic Therapy. 61
29606817 2018

Variations for Folliculotropic Mycosis Fungoides

Expression for Folliculotropic Mycosis Fungoides

Search GEO for disease gene expression data for Folliculotropic Mycosis Fungoides.

Pathways for Folliculotropic Mycosis Fungoides

Pathways related to Folliculotropic Mycosis Fungoides according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.71 CXCR3 CCR3
2
Show member pathways
10.96 CXCR3 CCR3

GO Terms for Folliculotropic Mycosis Fungoides

Cellular components related to Folliculotropic Mycosis Fungoides according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 8.62 CXCR3 CCR3

Biological processes related to Folliculotropic Mycosis Fungoides according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.46 CXCR3 CCR3
2 immune response GO:0006955 9.43 CXCR3 CCR3
3 inflammatory response GO:0006954 9.4 CXCR3 CCR3
4 positive regulation of cytosolic calcium ion concentration GO:0007204 9.37 CXCR3 CCR3
5 chemotaxis GO:0006935 9.32 CXCR3 CCR3
6 positive regulation of angiogenesis GO:0045766 9.26 CXCR3 CCR3
7 cell chemotaxis GO:0060326 9.16 CXCR3 CCR3
8 calcium-mediated signaling GO:0019722 8.96 CXCR3 CCR3
9 chemokine-mediated signaling pathway GO:0070098 8.62 CXCR3 CCR3

Molecular functions related to Folliculotropic Mycosis Fungoides according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 C-C chemokine binding GO:0019957 9.16 CXCR3 CCR3
2 C-C chemokine receptor activity GO:0016493 8.96 CXCR3 CCR3
3 chemokine receptor activity GO:0004950 8.62 CXCR3 CCR3

Sources for Folliculotropic Mycosis Fungoides

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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