MCID: FLL042
MIFTS: 31

Folliculotropic Mycosis Fungoides

Categories: Skin diseases, Blood diseases, Rare diseases

Aliases & Classifications for Folliculotropic Mycosis Fungoides

MalaCards integrated aliases for Folliculotropic Mycosis Fungoides:

Name: Folliculotropic Mycosis Fungoides 59
Mycosis Fungoides-Associated Follicular Mucinosis 59
Follicular Mycosis Fungoides 73

Characteristics:

Orphanet epidemiological data:

59
folliculotropic mycosis fungoides
Inheritance: Not applicable; Age of onset: Adult;

Classifications:



External Ids:

Orphanet 59 ORPHA178512
UMLS via Orphanet 74 C1627767
ICD10 via Orphanet 34 C84.0
UMLS 73 C1627767

Summaries for Folliculotropic Mycosis Fungoides

MalaCards based summary : Folliculotropic Mycosis Fungoides, also known as mycosis fungoides-associated follicular mucinosis, is related to mycosis fungoides and dermatitis, atopic. An important gene associated with Folliculotropic Mycosis Fungoides is CCR3 (C-C Motif Chemokine Receptor 3), and among its related pathways/superpathways are CCR5 Pathway in Macrophages and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. The drugs Mechlorethamine and Lenalidomide have been mentioned in the context of this disorder. Affiliated tissues include t cells, skin and bone.

Related Diseases for Folliculotropic Mycosis Fungoides

Graphical network of the top 20 diseases related to Folliculotropic Mycosis Fungoides:



Diseases related to Folliculotropic Mycosis Fungoides

Symptoms & Phenotypes for Folliculotropic Mycosis Fungoides

Drugs & Therapeutics for Folliculotropic Mycosis Fungoides

Drugs for Folliculotropic Mycosis Fungoides (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
2
Lenalidomide Approved Phase 1, Phase 2 191732-72-6 216326
3
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
4 triamcinolone acetonide Phase 2
5 Alkylating Agents Phase 2
6 glucocorticoids Phase 2
7 Nitrogen Mustard Compounds Phase 2
8 Hormone Antagonists Phase 2
9 Angiogenesis Inhibitors Phase 1, Phase 2
10 Triamcinolone diacetate Phase 2
11 Triamcinolone hexacetonide Phase 2
12 Hormones Phase 2
13 Angiogenesis Modulating Agents Phase 1, Phase 2
14 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
15 Anti-Bacterial Agents Phase 1, Phase 2
16 Immunoglobulin G Phase 1, Phase 2
17 Antibodies Phase 1, Phase 2
18 Immunoglobulins Phase 1, Phase 2
19 Antibodies, Monoclonal Phase 1, Phase 2
20 Immunosuppressive Agents Phase 1, Phase 2,Phase 2
21 Anti-Infective Agents Phase 1, Phase 2
22 Anti-Inflammatory Agents Phase 2
23 Antineoplastic Agents, Alkylating Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Durvalumab With or Without Lenalidomide in Treating Patients With Relapsed or Refractory Cutaneous or Peripheral T Cell Lymphoma Recruiting NCT03011814 Phase 1, Phase 2 Lenalidomide
2 Mechlorethamine Induced Contact Dermatitis Avoidance Study Recruiting NCT03380026 Phase 2 Triamcinolone;Valchlor 0.016 % Topical Gel
3 Brentuximab Vedotin and Lenalidomide in Treating Patients With Relapsed or Refractory T-Cell Lymphomas Not yet recruiting NCT03373305 Phase 1 Brentuximab Vedotin;Lenalidomide

Search NIH Clinical Center for Folliculotropic Mycosis Fungoides

Genetic Tests for Folliculotropic Mycosis Fungoides

Anatomical Context for Folliculotropic Mycosis Fungoides

MalaCards organs/tissues related to Folliculotropic Mycosis Fungoides:

41
T Cells, Skin, Bone, Bone Marrow

Publications for Folliculotropic Mycosis Fungoides

Articles related to Folliculotropic Mycosis Fungoides:

(show top 50) (show all 75)
# Title Authors Year
1
How to Discern Folliculotropic Mycosis Fungoides From Follicular Mucinosis Using a Pediatric Case. ( 29318909 )
2018
2
Immune privilege disruption in folliculotropic mycosis fungoides: investigation of major histocompatibility complex antigen expression. ( 29603194 )
2018
3
Folliculotropic mycosis fungoides presenting with a solitary lesion: Clinicopathological features and long-term follow-up data in a series of 9 cases. ( 29086994 )
2018
4
Juvenile-Onset Early-Stage Mycosis Fungoides-Associated Follicular Mucinosis: A Case Report. ( 29927752 )
2018
5
Folliculotropic Mycosis Fungoides in 20 Korean Cases: Clinical and Histopathologic Features and Response to Ultraviolet A-1 and/or Photodynamic Therapy. ( 29606817 )
2018
6
Folliculotropic mycosis fungoides. ( 29726638 )
2018
7
Reflectance Confocal Microscopy as New Diagnostic Tool in Folliculotropic Mycosis Fungoides. ( 29765972 )
2018
8
Clinical characteristics, risk factors and long-term outcome of 114 patients with folliculotropic mycosis fungoides. ( 28516243 )
2017
9
Low-dose methotrexate combined with superficial X-ray in the treatment of folliculotropic mycosis fungoides: A case report. ( 28984625 )
2017
10
Successful treatment of relapsed folliculotropic mycosis fungoides with mogamulizumab followed by intensity-modulated radiotherapy. ( 29068082 )
2017
11
Underrecognized clinical features of folliculotropic mycosis fungoides: a large clinical series. ( 28240409 )
2017
12
Langerhans cell histiocytosis followed by folliculotropic mycosis fungoides. ( 28670259 )
2017
13
Trichoscopic spectrum of folliculotropic mycosis fungoides. ( 28924975 )
2017
14
Folliculotropic mycosis fungoides is a heterogenous group. ( 28731259 )
2017
15
Folliculotropic mycosis fungoides associated with atopic dermatitis. ( 28731507 )
2017
16
Folliculotropic Mycosis Fungoides Associated with Autoimmune Hepatitis. ( 29252180 )
2017
17
Lymphoproliferative CD30-positive disorder in a patient with a folliculotropic mycosis fungoides. ( 28387989 )
2017
18
No Viral Transcripts Associated with Folliculotropic Mycosis Fungoides Using a High Throughput Sequencing Approach. ( 28448099 )
2017
19
Folliculotropic Mycosis Fungoides with Skewed T-cell Receptor CDR3 Motif: Suggestive of Lipid-antigen Selection? ( 28597017 )
2017
20
Recommendations for treatment in folliculotropic mycosis fungoides: report of the Dutch Cutaneous Lymphoma Group. ( 28132406 )
2017
21
Folliculotropic mycosis fungoides: challenging clinical, histopathological and immunohistochemical diagnosis. ( 29267452 )
2017
22
Clinical Staging and Prognostic Factors in Folliculotropic Mycosis Fungoides. ( 27276223 )
2016
23
Folliculotropic mycosis fungoides: clinical and epidemiological evaluation in a single center in Brazil. ( 26711732 )
2016
24
Folliculotropic Mycosis Fungoides in an Adolescent: A Rare Case. ( 27512205 )
2016
25
New insights into folliculotropic mycosis fungoides (FMF): A single-center experience. ( 27245278 )
2016
26
Clinical Efficacy of Romidepsin in Tumor Stage and Folliculotropic Mycosis Fungoides. ( 27637428 )
2016
27
Topical Carmustine as Monotherapy or as Multimodality Therapy for Folliculotropic Mycosis Fungoides. ( 27868149 )
2016
28
Folliculotropic Mycosis Fungoides: Clinical and Histologic Features in Five Patients. ( 27688448 )
2016
29
Case of folliculotropic mycosis fungoides with prominent loss of T-cell antigens CD7 and CD26 in blood T cells. ( 25495378 )
2015
30
Folliculotropic Mycosis Fungoides as a Posttransplant Lymphoproliferative Disorder. ( 26283779 )
2015
31
Merkel cell polyomavirus in low levels in folliculotropic mycosis fungoides represents a passenger, not a driver. ( 25661198 )
2015
32
Durable remission of folliculotropic mycosis fungoides achieved with a combined topical treatment with cytarabine and carmustine. ( 26278921 )
2015
33
Folliculotropic mycosis fungoides presenting as non-inflammatory scarring scalp alopecia associated with comedo-like lesions. ( 26518355 )
2015
34
Incidental folliculotropic mycosis fungoides in a blepharoplasty specimen performed for dermatochalasis. ( 24406420 )
2014
35
The Clinical Features And Histopathologic Patterns Of Folliculotropic Mycosis Fungoides In A Series Of 38 Patients. ( 25376535 )
2014
36
Multiple Distinct T-Cell Clones in Folliculotropic Mycosis Fungoides. ( 25140661 )
2014
37
Two cases of aggressive nontumoral folliculotropic mycosis fungoides with visceral involvement. ( 24779866 )
2014
38
Unilesional folliculotropic mycosis fungoides: a unique variant of cutaneous lymphoma. ( 25405551 )
2014
39
Unilesional folliculotropic mycosis fungoides: a true rarity in the clinico-pathologic spectrum? ( 25664821 )
2014
40
Two Clinically Unusual Cases of Folliculotropic Mycosis Fungoides: One with and the Other without Syringotropism. ( 24966641 )
2014
41
Folliculotropic mycosis fungoides: clinicopathological analysis of 17 patients. ( 25406034 )
2014
42
Folliculotropic mycosis fungoides with extreme pilosebaceous involvement and hematological abnormalities. ( 24589554 )
2014
43
Folliculotropic mycosis fungoides with rare secondary pulmonary extension: potential role of FDG PET/CT in the assessment of epidermotropic T cell lymphoma. ( 23774667 )
2013
44
Reduced-intensity conditioning followed by cord blood transplantation in a patient with refractory folliculotropic mycosis fungoides. ( 23943312 )
2013
45
Clinical and histopathological features of folliculotropic mycosis fungoides: a Norwegian patient series. ( 23053197 )
2013
46
Photodynamic therapy with methyl aminolaevulinate for cervical and/or facial lesions of folliculotropic mycosis fungoides: interest and limits. ( 23013351 )
2013
47
Combined granulomatous slack skin/folliculotropic mycosis fungoides: case report. ( 22320384 )
2013
48
Mycosis fungoides-associated follicular mucinosis after bone-marrow transplantation. ( 22583726 )
2012
49
Successful treatment of a folliculotropic mycosis fungoides with bexarotene and PUVA. ( 22240623 )
2012
50
Folliculotropic mycosis fungoides following renal transplantation. ( 21839313 )
2011

Variations for Folliculotropic Mycosis Fungoides

Expression for Folliculotropic Mycosis Fungoides

Search GEO for disease gene expression data for Folliculotropic Mycosis Fungoides.

Pathways for Folliculotropic Mycosis Fungoides

Pathways related to Folliculotropic Mycosis Fungoides according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.71 CCR3 CXCR3
2
Show member pathways
10.69 CCR3 CXCR3

GO Terms for Folliculotropic Mycosis Fungoides

Biological processes related to Folliculotropic Mycosis Fungoides according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell adhesion GO:0007155 9.32 CCR3 CXCR3
2 inflammatory response GO:0006954 9.26 CCR3 CXCR3
3 chemotaxis GO:0006935 9.16 CCR3 CXCR3
4 positive regulation of cytosolic calcium ion concentration GO:0007204 8.96 CCR3 CXCR3
5 chemokine-mediated signaling pathway GO:0070098 8.62 CCR3 CXCR3

Molecular functions related to Folliculotropic Mycosis Fungoides according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled receptor activity GO:0004930 9.16 CCR3 CXCR3
2 obsolete signal transducer activity GO:0004871 8.96 CCR3 CXCR3
3 chemokine receptor activity GO:0004950 8.62 CCR3 CXCR3

Sources for Folliculotropic Mycosis Fungoides

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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