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MCID: FDL002
MIFTS: 47

Food Allergy

Categories: Immune diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Food Allergy

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MalaCards integrated aliases for Food Allergy:

Name: Food Allergy 12 42 15 17 70
Food Hypersensitivity 12 44
Food Allergies 15 62
Allergy Food 54

Classifications:

MalaCards categories:
Anatomical: Immune diseases
See all MalaCards categories (disease lists)


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Disease Ontology 12 DOID:3044
MeSH 44 D005512
SNOMED-CT 67 213018006
UMLS 70 C0016470
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Summaries for Food Allergy

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MedlinePlus : 42 Food allergy is an abnormal response to a food triggered by your body's immune system. In adults, the foods that most often trigger allergic reactions include fish, shellfish, peanuts, and tree nuts, such as walnuts. Problem foods for children can include eggs, milk, peanuts, tree nuts, soy, and wheat. The allergic reaction may be mild. In rare cases it can cause a severe reaction called anaphylaxis. Symptoms of food allergy include Itching or swelling in your mouth Vomiting, diarrhea, or abdominal cramps and pain Hives or eczema Tightening of the throat and trouble breathing Drop in blood pressure Your health care provider may use a detailed history, elimination diet, and skin and blood tests to diagnose a food allergy. When you have food allergies, you must be prepared to treat an accidental exposure. Wear a medical alert bracelet or necklace, and carry an auto-injector device containing epinephrine (adrenaline). You can only prevent the symptoms of food allergy by avoiding the food. After you and your health care provider have identified the foods to which you are sensitive, you must remove them from your diet.

MalaCards based summary : Food Allergy, also known as food hypersensitivity, is related to fish allergy and wheat allergy. An important gene associated with Food Allergy is CSN1S1 (Casein Alpha S1), and among its related pathways/superpathways are Cytokine Signaling in Immune system and Allograft rejection. The drugs Caffeine and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and breast.

Disease Ontology : 12 A hypersensitivity reaction type I disease that is an abnormal response to a food, triggered by the body's immune system.

PubMed Health : 62 About food allergies: If someone keeps having the same reaction (e.g. nausea, a rash or feeling unwell) after eating certain foods, it may be logical to assume that they have a food allergy. But food allergies are actually less common than many people believe: The symptoms are often caused by something else instead. It’s important to get the right diagnosis in order to get the right treatment – and avoid removing certain foods from your diet for no reason.

Wikipedia : 73 A food allergy is an abnormal immune response to food. The symptoms of the allergic reaction may range... more...

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Related Diseases for Food Allergy

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Diseases related to Food Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 465)
# Related Disease Score Top Affiliating Genes
1 fish allergy 32.2 PVALB IGHE
2 wheat allergy 32.1 SCP2 IGHE ENPP3
3 peanut allergy 32.0 IL5 IL4 IL13 IL10 IGHE FLG
4 egg allergy 31.8 IL5 IL4 IL13 IL10 IGHE FOXP3
5 milk allergy 31.5 STAT6 RNASE3 IL5 IL4 IL13 IL10
6 ige responsiveness, atopic 31.4 RNASE3 IL5 IL4 IL13 IL10 IGHE
7 dermatitis 31.3 RNASE3 IL5 IL4 IL13 IL10 IGHE
8 fruit allergy 31.3 SCP2 IL5 IL4 IL13 IL10 FOXP3
9 esophagitis 31.2 STAT6 RNASE3 IL5 IL4 IL13 IL10
10 exercise-induced anaphylaxis 31.2 IGHE FLG ENPP3
11 nut allergy 31.2 STAT6 SCP2 IL5 IL4 IL13 IGHE
12 allergic disease 31.1 RNASE3 IL5 IL4 IL13 IL10 IGHE
13 esophagitis, eosinophilic, 1 31.1 STAT6 RNASE3 IL5 IL4 IL13 FLG
14 celiac disease 1 31.1 IL5 IL4 IL13 IL10 FOXP3
15 diarrhea 31.1 IL5 IL13 IL10 FOXP3
16 gastroenteritis 31.1 RNASE3 IL5 IL4 IL10 EPX
17 eosinophilic gastroenteritis 31.0 RNASE3 IL5 IL4 EPX
18 cytokine deficiency 31.0 IL5 IL13
19 contact dermatitis 31.0 IL5 IL4 IL10 FLG
20 hypereosinophilic syndrome 31.0 RNASE3 IL5 IL4 IL13 IGHE IGES
21 rhinitis 31.0 TPT1 RNASE3 IL5 IL4 IL13 IL10
22 occupational asthma 31.0 TPT1 IGHE
23 urticaria 30.9 TPT1 RNASE3 IL5 IL4 IL13 IL10
24 otitis media 30.9 RNASE3 IL5 IL4 IL10 IGHE
25 allergic rhinitis 30.9 TPT1 RNASE3 IL5 IL4 IL13 IL10
26 cow milk allergy 30.8 IL5 IL4 IL10 CSN3 CSN1S1
27 allergic asthma 30.8 STAT6 RNASE3 IL5 IL4 IL13 IL10
28 dermatitis, atopic 30.8 STAT6 RNASE3 IL5 IL4 IL13 IL10
29 mastocytosis 30.8 IL4 IL13 ENPP3
30 rubella 30.8 IL5 IL4 IL10
31 neurodermatitis 30.8 IL4 IL13 FLG
32 conjunctivitis 30.7 RNASE3 IL5 IL4 IL13 IL10 IGHE
33 dermatitis herpetiformis 30.7 IL5 IL4 IL10 FOXP3
34 latex allergy 30.7 RNASE3 IL5 IL4 IL13 IGHE FLG
35 chronic urticaria 30.7 TPT1 RNASE3 IL4 IL13 IGHE ENPP3
36 drug allergy 30.6 TPT1 IL5 IL13 IGHE ENPP3
37 colitis 30.5 IL4 IL13 IL10 FOXP3
38 bronchitis 30.5 RNASE3 IL5 IL4 IL13 IL10
39 pollen allergy 30.5 SCP2 RNASE3 IL5 IL13 IGHE FOXP3
40 tetanus 30.5 IL5 IL4 IL13 IL10
41 proteasome-associated autoinflammatory syndrome 1 30.4 RNASE3 IL5 IL4 IL13 IL10 IGHE
42 chronic asthma 30.4 RNASE3 IL5 IL4 IL13 IGHE
43 acute asthma 30.4 RNASE3 IL5 IL4
44 angioimmunoblastic lymphadenopathy with dysproteinemia 30.4 IL5 IL13
45 exercise-induced bronchoconstriction 30.4 RNASE3 IL13
46 diphtheria 30.4 IL5 IL4 IL13
47 inflammatory bowel disease 30.4 STAT6 IL5 IL4 IL13 IL10 FOXP3
48 orofacial granulomatosis 30.3 IL4 IL10 FLG
49 immunodysregulation, polyendocrinopathy, and enteropathy, x-linked 30.3 IL4 IL10 FOXP3
50 aphthous stomatitis 30.3 IL5 IL4 IL10

Graphical network of the top 20 diseases related to Food Allergy:



Diseases related to Food Allergy
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Symptoms & Phenotypes for Food Allergy

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Drugs & Therapeutics for Food Allergy

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PubMed Health treatment related to Food Allergy: 62

The main thing people can do to prevent allergic reactions is avoid the food that causes them. Medication is generally only used in acute situations, if people have a more severe allergic reaction . It doesn’t tend to be used for the long-term treatment of food allergies . Anaphylactic reactions are treated using emergency kits. These contain medications to reduce severe allergic reactions and prevent them from getting worse.

Drugs for Food Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 98)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Caffeine Approved Phase 4 58-08-2 2519
2
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
3
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
4
Montelukast Approved Phase 4 158966-92-8 5281040
5
Vitamin D3 Approved, Nutraceutical Phase 4 67-97-0 5280795 6221
6
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
7 Analgesics, Non-Narcotic Phase 4
8 Analgesics Phase 4
9 Antirheumatic Agents Phase 4
10 Mesalamine Phase 4 89-57-6
11 Anti-Inflammatory Agents, Non-Steroidal Phase 4
12 Calcium Supplement Phase 4
13 Proton Pump Inhibitors Phase 4
14 Gastrointestinal Agents Phase 4
15 diuretics Phase 4
16 Anti-Ulcer Agents Phase 4
17 Antacids Phase 4
18 Hormone Antagonists Phase 4
19 Leukotriene Antagonists Phase 4
20 Nutrients Phase 4
21 Trace Elements Phase 4
22 Vitamin D2 Phase 4
23 Ergocalciferols Phase 4
24 Hormones Phase 4
25 Micronutrients Phase 4
26 Calcium, Dietary Phase 4
27 Pharmaceutical Solutions Phase 4
28
Calcium Nutraceutical Phase 4 7440-70-2 271
29 English walnut Approved Phase 3
30
Omalizumab Approved, Investigational Phase 3 242138-07-4
31
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
32
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
33 Immunoglobulins Phase 3
34 Anti-Asthmatic Agents Phase 3
35 Respiratory System Agents Phase 3
36 Antibodies Phase 3
37 Immunologic Factors Phase 3
38 Antibodies, Monoclonal Phase 3
39 Anti-Allergic Agents Phase 3
40 Anti-Infective Agents Phase 3
41 Antifungal Agents Phase 3
42
Histamine Approved, Investigational Phase 2 51-45-6, 75614-87-8 774
43
Glycerol Approved, Investigational Phase 2 56-81-5 753
44
Fluticasone Approved, Experimental Phase 1, Phase 2 90566-53-3 62924
45
Hydrocortisone Approved, Vet_approved Phase 1, Phase 2 50-23-7 5754
46
Hydrocortisone acetate Approved, Vet_approved Phase 1, Phase 2 50-03-3
47
Petrolatum Approved, Investigational Phase 1, Phase 2 8009-03-8
48
Histamine Phosphate Phase 2 51-74-1 65513
49 Protective Agents Phase 2
50 Caseins Phase 2

Interventional clinical trials:

(show top 50) (show all 228)
# Name Status NCT ID Phase Drugs
1 CLINICAL MANAGEMENT OF CHILDHOOD INTESTINAL LYMPHOID NODULAR HYPERPLASIA: A RANDOMIZED CONTROLLED CLINICAL TRIAL. Unknown status NCT01789294 Phase 4 Mesalamine
2 Integrated Approaches to Food Allergen and Allergy Risk Management: iFAAM: The Impact of Proton-pump Inhibitors (Antacids) on Threshold Dose Distributions Completed NCT02552537 Phase 4 Omeprazole;Placebo
3 Phase 4 Study of Effects of Montelukast Treatment on Allergic Inflammation in Children With and Without Food Allergy, Single Centered, Randomised, Double Blind, Placebo Controlled Parallel Group Cross-over Study Completed NCT01618929 Phase 4 Montelukast
4 Basophil Activation Test (BAT) Sensitivity in Child Food Allergy Completed NCT01966640 Phase 4
5 Can Vitamin D Supplementation in Infants Prevent Food Allergy in the First Year of Life? The VITALITY Trial. Recruiting NCT02112734 Phase 4 Vitamin D;placebo
6 Protection From Food Induced Anaphylaxis by Reducing the Serum Level of Specific IgE (Protana). Recruiting NCT03964051 Phase 4 Omalizumab Injection
7 Treatment With Omalizumab in Food Allergic Children (TOFAC) Recruiting NCT04037176 Phase 4 Omalizumab
8 Use of Probiotic Bacteria in Prevention of Allergic Disease in Children 1999-2008 Unknown status NCT00298337 Phase 2, Phase 3 Mixture of probiotic bacteria and prebiotic oligosaccharide
9 THE PEBBLES STUDY: A Randomised Controlled Trial to Prevent Eczema, Food Allergy and Sensitisation Using a Skin Barrier Improvement Strategy Recruiting NCT03667651 Phase 3 EpiCeram
10 Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen Oral Immunotherapy (OIT) in Food Allergic Children and Adults (CoFAR-11) Recruiting NCT03881696 Phase 3 Omalizumab;Placebo for Omalizumab;Multi-Allergen Oral Immunotherapy;Placebo for Multi-Allergen Oral Immunotherapy
11 Open-label Follow-up Study of the PEPITES Study to Evaluate the Long-term Efficacy and Safety of Viaskin Peanut Active, not recruiting NCT03013517 Phase 3 Viaskin Peanut 250µg
12 Can Early Introduction of Tree Nuts Prevent Tree Nut Allergy in Infants at High Risk of Tree Nut Allergy: The TreEat Study: a Randomised, Open-label Controlled Trial Not yet recruiting NCT04801823 Phase 3
13 The Effect of Extrinsic Factors on Food Allergy Unknown status NCT01429896 Phase 2
14 Investigation of the Efficacy of the Food Allergy Herbal Formula (FAHF-2TM) in Patients With Food Allergy - Phase II Trial Unknown status NCT00602160 Phase 2 FAHF-2 (TM)
15 Explorative Open Phase II-study, Food Allergy Suppression Therapy During Protection With Xolair Unknown status NCT02402231 Phase 2 Omalizumab
16 A Phase II Multicenter, Controlled, Double-Blind Study Using Immunoprophylaxis in the Primary Prevention of Allergic Disease (ITN025AD) Completed NCT00346398 Phase 2
17 Oral Immunotherapy Combined With Humanized Monoclonal Anti-IgE Antibody Xolair® (Omalizumab)in the Treatment of Cow's Milk Allergy Completed NCT01157117 Phase 2 Milk powder
18 A Phase 2 Study Multi Oral Immunotherapy in Multi Food Allergic Patients to Test Immune Markers After Minimum Maintenance Dose Completed NCT03181009 Phase 2 Omalizumab;Food Flour Allergens
19 Inhibition of Anaphylaxis by Ibrutinib Completed NCT03149315 Phase 2 Ibrutinib
20 Oral Desensitization to Egg With Subsequent Induction of Sustained Unresponsiveness for Egg-Allergic Children Using Baked Egg or Egg Oral Immunotherapy (OIT) Completed NCT01846208 Phase 2 Egg Oral Immunotherapy;Baked Egg
21 A Multinational Phase IIb Study to Investigate the Efficacy and Safety of Subcutaneous Immunotherapy With a Modified Fish- Parvalbumin Given in Single Rising and Maintenance Doses to Subjects Allergic to Fish Completed NCT02382718 Phase 2
22 Randomized, Controlled, Blinded, Pilot Study Using Xolair in Rush Multi Oral Immunotherapy in Multi Food Allergic Patients Completed NCT02643862 Phase 1, Phase 2 Xolair;Placebo
23 Effects of Omalizumab on Peanut Allergen Induced Cellular and Clinical Responses in Peanut Allergic Adults Completed NCT00949078 Phase 2 omalizumab
24 A Double-Blind, Placebo-Controlled Randomized Trial to Study the Viaskin Milk Efficacy and Safety for Treating IgE-Mediated Cow's Milk Allergy in Children Completed NCT02223182 Phase 1, Phase 2
25 A Phase 2 Study Multi Oral Immunotherapy in Multi Food Allergic Patients to Test Tolerance M-TAX Study Completed NCT02626611 Phase 2 Omalizumab;Food Flour Buildup
26 FAST-Fish -Food Allergy Specific Treatment for Fish Allergy. Completed NCT02017626 Phase 1, Phase 2
27 Mechanisms of Desensitization During Peanut Oral Immunotherapy Completed NCT01814241 Phase 2 Open label peanut OIT
28 A Double-blinded, Placebo-controlled Study of Peanut Sublingual Immunotherapy in Children - DBPC Peanut SLIT Completed NCT00597727 Phase 2 Peanut SLIT;Placebo SLIT
29 Oral Immunotherapy for Peanut Allergy (2nd Generation PMIT Collaboration With Arkansas Children's) Completed NCT00597675 Phase 2
30 Sublingual Immunotherapy for Peanut Allergy: A Randomized, Double-Blind, Placebo-Controlled, Phase I/II Pilot Study With a Whole Peanut Extract Completed NCT00580606 Phase 1, Phase 2 Glycerinated peanut allergenic extract;Placebo for peanut extract (glycerin)
31 Dietary Intervention in Milk Allergy and Tolerance Development Completed NCT00778258 Phase 2
32 Determining the Efficacy and Value of Immunotherapy on the Likelihood of Peanut Tolerance: The DEVIL Study; Grant "Optimizing Tolerance Induction in Peanut Allergy: The DEVIL Study" Completed NCT00932828 Phase 2 Peanut oral immunotherapy
33 Oral Desensitization to Egg With Subsequent Induction of Tolerance for Egg-Allergic Children (CoFAR 3) Completed NCT00461097 Phase 2 Egg oral immunotherapy;Control Group
34 Induction of Tolerance Through Early Introduction of Peanut in High-Risk Children (ITN032AD) Completed NCT00329784 Phase 2
35 A Randomized, Double-Blind, Placebo-Controlled Pilot Study of Sublingual/Oral Immunotherapy for the Treatment of Peanut Allergy Completed NCT01084174 Phase 1, Phase 2 Peanut powder;Peanut extract;Placebo extract;Placebo powder
36 An Investigation Into the Effectiveness of NAET on Autism Spectrum Disorders Completed NCT00247156 Phase 1, Phase 2
37 Epicutaneous Immunotherapy (EPIT) for Peanut Allergy: A Randomized, Double-Blind, Placebo-Controlled, Phase II Study in Children and Adults (DAIT COFAR6) Completed NCT01904604 Phase 2
38 Peanut Sublingual Immunotherapy Induction of Clinical Tolerance of Newly Diagnosed Peanut Allergic 12 to 48 Month Old Children Completed NCT02304991 Phase 2 Liquid Peanut Extract;Placebo Glycerin SLIT
39 The Persistence of Oral Tolerance Induction to Peanut and Its Immunological Basis (ITN049AD) Completed NCT01366846 Phase 2
40 Peanut Sublingual Immunotherapy and Induction of Clinical Tolerance in Peanut Allergic Children (SLIT Tolerance TLC) {Sublingual Immunotherapy for Peanut Allergy} Completed NCT01373242 Phase 1, Phase 2 Liquid peanut extract (Peanut SLIT)
41 T Cell Reagent Research for Monitoring T Cells in Food Allergy (MOTIF) Phase 2 Study Using Food Allergen Oral Immunotherapy for Shrimp or Cashew Allergies Recruiting NCT03504774 Phase 2 Cashew or Shrimp Oral Immunotherapy
42 Low Dose Multi Allergen Oral Immunotherapy for Food Allergy Recruiting NCT03799328 Phase 2
43 Challenging to Food With Escalating Thresholds for Reducing Food Allergy Recruiting NCT03907397 Phase 2
44 Prospective Study to Identify Food-Specific and Component IgE Threshold Levels That Predict Food Allergy in Patients With Elevated Total Serum IgE Levels and Atopic Dermatitis Recruiting NCT03835767 Phase 2
45 A 15 Months, Double-Blind, Randomized Controlled Trial Comparing 20 Weeks of Two Dosages of Omalizumab to Placebo to Accelerate a Symptom-driven Oral Immunotherapy Schedule in Subjects Aged 6 to 25 Years With Multiple Food Allergies Recruiting NCT04045301 Phase 2
46 Phase 2 Randomized Controlled Trial Using Biologics to Improve Multi OIT Outcomes Recruiting NCT03679676 Phase 2 Omalizumab;Dupilumab
47 Double-Blind, Placebo-Controlled Phase 2 Study to Assess Safety and Efficacy of Chinese Herbal Therapy and Multiple Food Allergen Oral Immunotherapy Active, not recruiting NCT02879006 Phase 2 Chinese Herbal Medication;Placebo;Omalizumab;Multi OIT
48 Phase 2 Study of Omalizumab in Oral Peanut Desensitization Active, not recruiting NCT01781637 Phase 1, Phase 2 Omalizumab;placebo
49 Outcomes of Clinical Food Oral Immunotherapy for Peanut Allergy Enrolling by invitation NCT04222491 Phase 2 Peanut oral immunotherapy
50 Intra-lymphatic Immunotherapy for the Management of Peanut Allergy Not yet recruiting NCT04200989 Phase 1, Phase 2

Search NIH Clinical Center for Food Allergy

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Cromolyn
Cromolyn Sodium

Cochrane evidence based reviews: food hypersensitivity

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Genetic Tests for Food Allergy

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Anatomical Context for Food Allergy

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MalaCards organs/tissues related to Food Allergy:

40
Skin, T Cells, Breast, Liver, Tongue, B Cells, Small Intestine
Sources

Publications for Food Allergy

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Articles related to Food Allergy:

(show top 50) (show all 9338)
# Title Authors PMID Year
1
Management of Allergic Diseases During COVID-19 Outbreak. 42 61
33560451 2021
2
Prevalence of Self-Reported Food Allergies and Their Association with Other Health Conditions among Adults in Saudi Arabia. 61 42
33466448 2021
3
Food anaphylaxis in the United Kingdom: analysis of national data, 1998-2018. 42
33597169 2021
4
[Component-based diagnostic approach. Detection of sensitization to lipid transfer proteins in food allergy]. 61 54
20390241 2010
5
Anaphylaxis to wheat flour-derived foodstuffs and the lipid transfer protein syndrome: a potential role of wheat lipid transfer protein Tri a 14. 61 54
20016200 2010
6
Food allergy after liver transplantation in children: a prospective study. 54 61
19239659 2009
7
Usefulness of wheat and soybean specific IgE antibody titers for the diagnosis of food allergy. 61 54
19776678 2009
8
Food allergy among children in the United States. 61 54
19917585 2009
9
Component-resolved diagnosis of pollen allergy based on skin testing with profilin, polcalcin and lipid transfer protein pan-allergens. 61 54
19877313 2009
10
Is serum total IgE levels a good predictor of allergies in children? 61 54
19813686 2009
11
The non-specific lipid transfer protein, Ara h 9, is an important allergen in peanut. 54 61
19624524 2009
12
Management of cow's milk protein allergy in infants and young children: an expert panel perspective. 61 54
19702611 2009
13
Maize food allergy: lipid-transfer proteins, endochitinases, and alpha-zein precursor are relevant maize allergens in double-blind placebo-controlled maize-challenge-positive patients. 61 54
19669736 2009
14
The role of immunoglobulin E-binding epitopes in the characterization of food allergy. 61 54
19568005 2009
15
Elevation of plasma eotaxin levels in children with food allergy. 61 54
19564714 2009
16
Detection of IgE, IgG, IgA and IgM antibodies against raw and processed food antigens. 61 54
19435515 2009
17
EpidemAAITO: features of food allergy in Italian adults attending allergy clinics: a multi-centre study. 61 54
19220321 2009
18
Food allergy in Alergológica-2005. 54 61
19530417 2009
19
Cytokine profile in children with asthma undergoing food challenges. 54 61
19274928 2009
20
Is caesarean delivery associated with sensitization to food allergens and IgE-mediated food allergy: a systematic review. 61 54
19076564 2008
21
Association factors for atopic dermatitis in nursery school children in Ishigaki islands - Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). 61 54
18693163 2008
22
Helicobacter pylori as a protective factor against food allergy. 54 61
18758415 2008
23
The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy. 54 61
18502490 2008
24
The role of protein digestibility and antacids on food allergy outcomes. 54 61
18539189 2008
25
Confirmation of the association between high levels of immunoglobulin E food sensitization and eczema in infancy: an international study. 61 54
18028467 2008
26
Lupin sensitization and clinical allergy in food allergic children in Norway. 54 61
18076722 2008
27
Asthma and food allergy. 54 61
18043270 2008
28
The predictive value of specific immunoglobulin E levels for the first diagnosis of cow's milk allergy. A critical analysis of pediatric literature. 54 61
17651374 2007
29
Uveitis associated with immunoglobulin E-mediated allergic diseases. 54 61
17894692 2007
30
Hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age. 61 54
17498216 2007
31
Lipid transfer protein allergy: primary food allergy or pollen/food syndrome in some cases. 61 54
17489047 2007
32
Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene. 61 54
17484868 2007
33
Influence of the allelic variants encoded at the Gli-B1 locus, responsible for a major allergen of wheat, on IgE reactivity for patients suffering from food allergy to wheat. 61 54
17263477 2007
34
Thioredoxin and food allergy. 61 54
17141854 2007
35
[Contribution of indicators of sensitized T lymphocytes in the diagnosis of IgE independent and IgE dependent cow's allergy in children]. 54 61
17965461 2007
36
Wheat IgE-mediated food allergy in European patients: alpha-amylase inhibitors, lipid transfer proteins and low-molecular-weight glutenins. Allergenic molecules recognized by double-blind, placebo-controlled food challenge. 54 61
17496422 2007
37
Food allergy to proteins. 54 61
17245088 2007
38
Rice: another potential cause of food allergy in patients sensitized to lipid transfer protein. 61 54
17192718 2007
39
Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. 54 61
16815152 2006
40
Prevalence of elevated total IgE and food allergies in a consecutive series of ENT pediatric patients. 54 61
16564375 2006
41
Eosinophilic esophagitis. 54 61
16606552 2006
42
Measurements of eosinophil activation before and after food challenges in adults with food hypersensitivity. 61 54
16757922 2006
43
[Eosinophil cationic protein as a marker of eosinophil activity]. 61 54
17203813 2006
44
Sensitivity and specificity of food specific IgE and IgG determinations for the diagnosis of food allergy. 54 61
16673562 2006
45
Time course of total and food specific IgE antibodies (Rast Fx5) in the developing allergic child. 61 54
16285230 2005
46
Utility of the ratio of food-specific IgE/total IgE in predicting symptomatic food allergy in children. 54 61
15969684 2005
47
Controlled oral food challenges in children--when indicated, when superfluous? 61 54
15932374 2005
48
Epsilon germ-line and IL-4 transcripts are expressed in human intestinal mucosa and enhanced in patients with food allergy. 61 54
15876314 2005
49
Peanut- and cow's milk-specific IgE, Th2 cells and local anaphylactic reaction are induced in Balb/c mice orally sensitized with cholera toxin. 61 54
15813812 2005
50
Food allergen sensitization in inner-city children with asthma. 61 54
15867869 2005
Sources

Variations for Food Allergy

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Expression for Food Allergy

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Search GEO for disease gene expression data for Food Allergy.
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Pathways for Food Allergy

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Pathways related to Food Allergy according to GeneCards Suite gene sharing:

(show all 21)
# Super pathways Score Top Affiliating Genes
1
Cytokine Signaling in Immune system 65
Show member pathways
 13.22 STAT6 IL5 IL4 IL13 IL10 IGHE
2
Allograft rejection 1 36
Show member pathways
 12.69 RNASE3 IL5 IL4 IL13 IL10 FOXP3
3
Th17 cell differentiation 36
Show member pathways
 12.49 STAT6 IL5 IL4 IL13 IL10 FOXP3
4
NF-kappaB Signaling 4
12.45 TPT1 STAT6 IL4 IL10 FOXP3 ENPP3
5
JAK-STAT signaling pathway 36
Show member pathways
 12.32 STAT6 IL5 IL4 IL13 IL10
6
Development IGF-1 receptor signaling 23
Show member pathways
 12.26 STAT6 IL4 IGHE FCER2
7
Hematopoietic cell lineage 36
11.76 IL5 IL4 FCER2
8
Innate Lymphoid Cell Differentiation Pathways 64
11.71 IL5 IL4 IL13 IL10
9
Interleukin-4 and 13 signaling 65
11.69 STAT6 IL4 IL13 IL10 IGHE FCER2
10
Glucocorticoid receptor regulatory network 1
11.67 IL5 IL4 IL13
11
IgA-Producing B Cells in the Intestine 64
11.62 IL5 IL4 IL10 FOXP3
12
Calcineurin-regulated NFAT-dependent transcription in lymphocytes 1
Show member pathways
 11.61 IL5 IL4 FOXP3
13
Lung fibrosis 1
11.52 IL5 IL4 IL13
14
Interleukin-10 signaling 65
11.36 IL4 IL13 IL10 FCER2
15
IL4-mediated signaling events 1
11.23 STAT6 IL5 IL4 IL10 IGHE FCER2
16
Development and heterogeneity of the ILC family 1
11.22 IL5 IL4 IL13
17
Cytokines and Inflammatory Response 1
11.09 IL5 IL4 IL13 IL10
18
OX40 Pathway 63
10.97 IL5 IL4 IL13 IL10
19
IL-4 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.83 STAT6 IL4
20
Th2 Differentiation Pathway 64
10.76 STAT6 IL5 IL4 IL13 IL10 FOXP3
21
IL-9 Signaling Pathways and their Primary Biological Effects in Different Immune Cell Types 64
10.69 IL5 IL4 IL13
Sources

GO Terms for Food Allergy

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Cellular components related to Food Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 TPT1 RNASE3 IL5 IL4 IL13 IL10
2 extracellular region GO:0005576 9.44 RNASE3 IL5 IL4 IL13 IL10 IGHE

Biological processes related to Food Allergy according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.95 IL5 IL4 IL13 IL10 IGHE
2 defense response to bacterium GO:0042742 9.87 RNASE3 IL10 IGHE EPX
3 positive regulation of cold-induced thermogenesis GO:0120162 9.76 STAT6 IL4 IL13
4 negative regulation of tumor necrosis factor production GO:0032720 9.71 IL4 IL10 FOXP3
5 positive regulation of B cell proliferation GO:0030890 9.63 IL5 IL4 IL13
6 negative regulation of endothelial cell apoptotic process GO:2000352 9.61 IL4 IL13 IL10
7 macrophage activation GO:0042116 9.58 IL4 IL13
8 positive regulation of MHC class II biosynthetic process GO:0045348 9.56 IL4 IL10
9 negative regulation of T-helper 17 cell differentiation GO:2000320 9.52 IL4 FOXP3
10 positive regulation of mast cell degranulation GO:0043306 9.51 IL4 IL13
11 negative regulation of interleukin-5 production GO:0032714 9.49 FOXP3 EPX
12 type 2 immune response GO:0042092 9.48 IL4 IL10
13 negative regulation of complement-dependent cytotoxicity GO:1903660 9.4 IL4 IL13
14 positive regulation of isotype switching to IgE isotypes GO:0048295 9.37 STAT6 IL4
15 negative regulation of inflammatory response GO:0050728 9.35 IL4 IL13 IL10 FOXP3 ENPP3
16 positive regulation of immunoglobulin production GO:0002639 9.33 IL5 IL13 IL10
17 regulation of isotype switching GO:0045191 9.32 IL4 IL10
18 negative regulation of chronic inflammatory response GO:0002677 9.26 IL4 FOXP3
19 cytokine-mediated signaling pathway GO:0019221 9.17 STAT6 IL5 IL4 IL13 IL10 IGHE

Molecular functions related to Food Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 IL5 IL4 IL13 IL10
Sources

Sources for Food Allergy

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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