MCID: FDL002
MIFTS: 53

Food Allergy

Categories: Immune diseases
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Aliases & Classifications for Food Allergy

MalaCards integrated aliases for Food Allergy:

Name: Food Allergy 11 41 14 16 71 75 33
Food Hypersensitivity 11 43 33
Food Allergies 14 63
Food Allergen-Induced Hypersensitivity 33
Allergy Food 53

Classifications:



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Disease Ontology 11 DOID:3044
MeSH 43 D005512
NCIt 49 C172304
SNOMED-CT 68 213018006
UMLS 71 C0016470

Summaries for Food Allergy

MedlinePlus: 41 Food allergy is an abnormal response to a food triggered by your body's immune system. In adults, the foods that most often trigger allergic reactions include fish, shellfish, peanuts, and tree nuts, such as walnuts. Problem foods for children can include eggs, milk, peanuts, tree nuts, soy, and wheat. The allergic reaction may be mild. In rare cases it can cause a severe reaction called anaphylaxis. Symptoms of food allergy include: Itching or swelling in your mouth Vomiting, diarrhea, or abdominal cramps and pain Hives or eczema Tightening of the throat and trouble breathing Drop in blood pressure Your health care provider may use a detailed history, elimination diet, and skin and blood tests to diagnose a food allergy. When you have food allergies, you must be prepared to treat an accidental exposure. Wear a medical alert bracelet or necklace, and carry an auto-injector device containing epinephrine (adrenaline). You can only prevent the symptoms of food allergy by avoiding the food. After you and your health care provider have identified the foods to which you are sensitive, you must remove them from your diet.

MalaCards based summary: Food Allergy, also known as food hypersensitivity, is related to egg allergy and wheat allergy. An important gene associated with Food Allergy is CSN1S1 (Casein Alpha S1), and among its related pathways/superpathways are Innate Immune System and TGF-Beta Pathway. The drugs Esomeprazole and Sorbitol have been mentioned in the context of this disorder. Affiliated tissues include skin, tongue and t cells, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

PubMed Health : 63 Food allergies: If someone keeps having the same reaction (e.g. nausea, a rash or feeling unwell) after eating certain foods, it may be logical to assume that they have a food allergy. But food allergies are actually less common than many people believe: The symptoms are often caused by something else instead. It’s important to get the right diagnosis in order to get the right treatment – and avoid removing certain foods from your diet for no reason.

Disease Ontology: 11 A hypersensitivity reaction type I disease that is an abnormal response to a food, triggered by the body's immune system.

Wikipedia: 75 A food allergy is an abnormal immune response to food. The symptoms of the allergic reaction may range... more...

Related Diseases for Food Allergy

Diseases related to Food Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 659)
# Related Disease Score Top Affiliating Genes
1 egg allergy 32.3 IL5 IL4 IL13 IGHE FOXP3
2 wheat allergy 32.3 SCP2 IGHE
3 fruit allergy 32.2 SCP2 IL5 IL4 IL13 FOXP3
4 nut allergy 32.1 SCP2 IL5 IL4 IL13 IGHE
5 peanut allergy 32.0 SCP2 IL5 IL4 IL13 IGHE IFNG
6 milk allergy 32.0 RNASE3 IL5 IL4 IL13 IGHE IGES
7 chronic rhinitis 31.9 RNASE3 IL5 IL4 IL13
8 eosinophilic gastroenteritis 31.5 RNASE3 IL5 IL4 IL13 IGHE EPX
9 dermatitis 31.5 TNF RNASE3 IL5 IL4R IL4 IL13
10 urticaria 31.4 TNF RNASE3 IL5 IL4 IL13 IGHE
11 esophagitis, eosinophilic, 1 31.4 STAT6 RNASE3 IL5 IL4 IL13 EPX
12 ige responsiveness, atopic 31.3 STAT6 RNASE3 IL5 IL4R IL4 IL13
13 allergic rhinitis 31.3 RNASE3 IL5 IL4R IL4 IL13 IGHE
14 esophagitis 31.3 TNF STAT6 RNASE3 IL5 IL4 IL13
15 pollen allergy 31.2 SCP2 IL5 IL4 IL13
16 diarrhea 31.2 TNF IL5 IL13 IFNG FOXP3 CXCL8
17 chronic urticaria 31.2 RNASE3 IL5 IGHE
18 irritable bowel syndrome 31.2 TNF IL4 CXCL8
19 cholera 31.2 TNF IL5 IL4 IFNG CXCL8
20 gastroesophageal reflux 31.1 TNF IL5 IL4 FOXP3 CXCL8
21 celiac disease 1 31.1 TNF IL5 IL4 IL13 IFNG FOXP3
22 exanthem 31.0 TNF IL4 IFNG CXCL8
23 rhinitis 31.0 TNF RNASE3 IL5 IL4R IL4 IL13
24 drug allergy 31.0 IL5 IL4 IL13 IGHE
25 latex allergy 30.9 SCP2 IL13 IGHE
26 cow milk allergy 30.9 IL5 IL4 IL13 CSN3 CSN1S1
27 dermatitis, atopic 30.9 TNF STAT6 RNASE3 LGALS3 IL5 IL4R
28 allergic asthma 30.9 STAT6 RNASE3 IL5 IL4R IL4 IL13
29 childhood-onset asthma 30.9 RNASE3 IL5 IL4R IL4 IL13 IGHE
30 hypereosinophilic syndrome 30.9 RNASE3 IL5 IL4 IL13 IGHE IGES
31 allergic disease 30.9 TNF RNASE3 LGALS3 IL5 IL4R IL4
32 gastroenteritis 30.9 TNF RNASE3 IL5 IL4 IFNG EPX
33 occupational asthma 30.8 RNASE3 IL5 IL4 IL13 CXCL8
34 rubella 30.8 TNF IL5 IL4 IFNG
35 neurodermatitis 30.8 IL4 IL13
36 apple allergy 30.8 SCP2 PVALB
37 mumps 30.7 TNF IFNG CXCL8
38 asthma 30.7 TNF STAT6 RNASE3 IL5 IL4R IL4
39 nephrotic syndrome 30.7 TNF IL4R IL4 IL13 IGES CETP
40 respiratory allergy 30.7 TNF STAT6 RNASE3 IL5 IL4R IL4
41 common cold 30.7 TNF RNASE3 IL5 IL4 IL13 CXCL8
42 dermatitis herpetiformis 30.6 TNF IL5 IL4 CXCL8
43 proctitis 30.6 TNF RNASE3 EPX AOC1
44 autoimmune disease 30.6 TNF IL5 IL4 IL13 IFNG FOXP3
45 otitis media 30.6 TNF RNASE3 IL5 IL4 IL13 IGHE
46 shrimp allergy 30.6 SCP2 IL13
47 contact dermatitis 30.5 TNF STAT6 RNASE3 IL5 IL4 IL13
48 purpura 30.5 TNF IL4 IFNG CXCL8
49 skin disease 30.5 TNF STAT6 RNASE3 IL5 IL4 IL13
50 colitis 30.5 TNF STAT6 IL5 IL4 IL13 IFNG

Graphical network of the top 20 diseases related to Food Allergy:



Diseases related to Food Allergy

Symptoms & Phenotypes for Food Allergy

MGI Mouse Phenotypes related to Food Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.25 AOC1 CSN1S1 EPX FOXP3 IFNG IL13
2 endocrine/exocrine gland MP:0005379 10.11 AOC1 CSN1S1 CSN3 FOXP3 IFNG IL13
3 liver/biliary system MP:0005370 10.09 FOXP3 IFNG IL4 IL4R IL5 LGALS3
4 immune system MP:0005387 10.03 EPX FOXP3 IFNG IGHE IL13 IL4
5 no phenotypic analysis MP:0003012 10 FOXP3 IFNG IGHE IL13 IL4 PVALB
6 digestive/alimentary MP:0005381 9.92 FOXP3 IFNG IL13 IL4 IL4R IL5
7 respiratory system MP:0005388 9.81 FOXP3 IFNG IL13 IL4 IL4R IL5
8 hematopoietic system MP:0005397 9.73 EPX FOXP3 IFNG IGHE IL13 IL4
9 integument MP:0010771 9.32 CSN1S1 CSN3 FOXP3 IFNG IL13 IL4

Drugs & Therapeutics for Food Allergy

PubMed Health treatment related to Food Allergy: 63

The main thing people can do to prevent allergic reactions is avoid the food that causes them. Medication is generally only used in acute situations, if people have a more severe allergic reaction . It doesn’t tend to be used for the long-term treatment of food allergies . Anaphylactic reactions are treated using emergency kits. These contain medications to reduce severe allergic reactions and prevent them from getting worse.

Drugs for Food Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 86)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Esomeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6, 119141-88-7 9568614 4594
2
Sorbitol Approved, Investigational Phase 4 69-65-8, 50-70-4 453 6251 5780
3
Montelukast Approved Phase 4 158966-92-8 5281040
4
Omalizumab Approved, Investigational Phase 4 242138-07-4
5
Cholecalciferol Approved, Nutraceutical, Vet_approved Phase 4 67-97-0, 1406-16-2 5280795 10883523
6
Ergocalciferol Approved, Nutraceutical Phase 4 50-14-6 5280793
7 Proton Pump Inhibitors Phase 4
8 Anti-Ulcer Agents Phase 4
9 Antacids Phase 4
10 Gastrointestinal Agents Phase 4
11 diuretics Phase 4
12 Leukotriene Antagonists Phase 4
13 Hormone Antagonists Phase 4
14 Pharmaceutical Solutions Phase 4
15 Anti-Asthmatic Agents Phase 4
16 Anti-Allergic Agents Phase 4
17 Respiratory System Agents Phase 4
18 Vitamins Phase 4
19 Calciferol Phase 4
20
Vitamin D2 Phase 4 3249
21 Trace Elements Phase 4
22 Hormones Phase 4
23 Ergocalciferols Phase 4
24 Calcium, Dietary Phase 4
25 Micronutrients Phase 4
26
Calcium Nutraceutical Phase 4 7440-70-2 271
27 English walnut Approved Phase 3
28
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
29
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
30
Capric acid Experimental Phase 3 59906-14-8, 334-48-5 2969
31 Antibodies, Monoclonal Phase 3
32 Immunologic Factors Phase 3
33 Anti-Infective Agents Phase 3
34 Antifungal Agents Phase 3
35
Glycerin Approved, Investigational Phase 2 56-81-5 753
36
Histamine Approved, Investigational Phase 2 51-45-6 774
37
Acalabrutinib Approved, Investigational Phase 2 1420477-60-6 71226663 71226662
38
D-Tyrosine Approved, Experimental, Investigational, Nutraceutical Phase 2 133585-56-5, 60-18-4, 556-02-5 1153 6057
39 Protective Agents Phase 2
40
Histamine phosphate Phase 2 51-74-1 134614
41 Vaccines Phase 2
42 Immunoglobulins Phase 2
43 Antibodies Phase 2
44 Soy Bean Phase 1, Phase 2
45
Phenol Approved, Experimental Phase 1 108-95-2 996
46
Abrocitinib Approved, Investigational Phase 1 1622902-68-4 78323835
47 Antiviral Agents Phase 1
48 Hypoxanthine arabinoside Phase 1
49 Janus Kinase Inhibitors Phase 1
50 Protein Kinase Inhibitors Phase 1

Interventional clinical trials:

(show top 50) (show all 238)
# Name Status NCT ID Phase Drugs
1 Integrated Approaches to Food Allergen and Allergy Risk Management: iFAAM: The Impact of Proton-pump Inhibitors (Antacids) on Threshold Dose Distributions Completed NCT02552537 Phase 4 Omeprazole;Placebo
2 Phase 4 Study of Effects of Montelukast Treatment on Allergic Inflammation in Children With and Without Food Allergy, Single Centered, Randomised, Double Blind, Placebo Controlled Parallel Group Cross-over Study Completed NCT01618929 Phase 4 Montelukast
3 Basophil Activation Test (BAT) Sensitivity in Child Food Allergy Completed NCT01966640 Phase 4
4 Treatment With Omalizumab in Food Allergic Children (TOFAC) Recruiting NCT04037176 Phase 4 Omalizumab
5 Can Vitamin D Supplementation Prevent Food Allergy in Infants? The VITALITY Trial Active, not recruiting NCT02112734 Phase 4 Vitamin D;placebo
6 Protection From Food Induced Anaphylaxis by Reducing the Serum Level of Specific IgE (Protana). Active, not recruiting NCT03964051 Phase 4 Omalizumab Injection
7 Use of Probiotic Bacteria in Prevention of Allergic Disease in Children 1999-2008 Unknown status NCT00298337 Phase 2, Phase 3 Mixture of probiotic bacteria and prebiotic oligosaccharide
8 Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen Oral Immunotherapy (OIT) in Food Allergic Children and Adults (CoFAR-11) Recruiting NCT03881696 Phase 3 Omalizumab;Placebo for Omalizumab;Multi-Allergen Oral Immunotherapy;Placebo for Multi-Allergen Oral Immunotherapy
9 Can Early Introduction of Tree Nuts Prevent Tree Nut Allergy in Infants at High Risk of Tree Nut Allergy: The TreEat Study: a Randomised, Open-label Controlled Trial Recruiting NCT04801823 Phase 3
10 THE PEBBLES STUDY: A Randomised Controlled Trial to Prevent Eczema, Food Allergy and Sensitisation Using a Skin Barrier Improvement Strategy Active, not recruiting NCT03667651 Phase 3 EpiCeram
11 Investigation of the Efficacy of the Food Allergy Herbal Formula (FAHF-2TM) in Patients With Food Allergy - Phase II Trial Unknown status NCT00602160 Phase 2 FAHF-2 (TM)
12 Double-Blind, Placebo-Controlled Phase 2 Study to Assess Safety and Efficacy of Chinese Herbal Therapy and Multiple Food Allergen Oral Immunotherapy Unknown status NCT02879006 Phase 2 Chinese Herbal Medication;Placebo;Omalizumab;Multi OIT
13 Explorative Open Phase II-study, Food Allergy Suppression Therapy During Protection With Xolair Unknown status NCT02402231 Phase 2 Omalizumab
14 The Effect of Extrinsic Factors on Food Allergy Unknown status NCT01429896 Phase 2
15 Randomized, Controlled, Blinded, Pilot Study Using Xolair in Rush Multi Oral Immunotherapy in Multi Food Allergic Patients Completed NCT02643862 Phase 1, Phase 2 Xolair;Placebo
16 Peanut Sublingual Immunotherapy Induction of Clinical Tolerance of Newly Diagnosed Peanut Allergic 12 to 48 Month Old Children Completed NCT02304991 Phase 2 Liquid Peanut Extract;Placebo Glycerin SLIT
17 A Phase 2 Study Multi Oral Immunotherapy in Multi Food Allergic Patients to Test Tolerance M-TAX Study Completed NCT02626611 Phase 2 Omalizumab;Food Flour Buildup
18 Oral Desensitization to Egg With Subsequent Induction of Sustained Unresponsiveness for Egg-Allergic Children Using Baked Egg or Egg Oral Immunotherapy (OIT) Completed NCT01846208 Phase 2 Egg Oral Immunotherapy;Baked Egg
19 Inhibition of Anaphylaxis by Ibrutinib Completed NCT03149315 Phase 2 Ibrutinib
20 A Phase 2 Study Multi Oral Immunotherapy in Multi Food Allergic Patients to Test Immune Markers After Minimum Maintenance Dose Completed NCT03181009 Phase 2 Omalizumab;Food Flour Allergens
21 Effects of Omalizumab on Peanut Allergen Induced Cellular and Clinical Responses in Peanut Allergic Adults Completed NCT00949078 Phase 2 omalizumab
22 Induction of Tolerance Through Early Introduction of Peanut in High-Risk Children (ITN032AD) Completed NCT00329784 Phase 2
23 A Multinational Phase IIb Study to Investigate the Efficacy and Safety of Subcutaneous Immunotherapy With a Modified Fish- Parvalbumin Given in Single Rising and Maintenance Doses to Subjects Allergic to Fish Completed NCT02382718 Phase 2
24 Peanut Sublingual Immunotherapy and Induction of Clinical Tolerance in Peanut Allergic Children (SLIT Tolerance TLC) {Sublingual Immunotherapy for Peanut Allergy} Completed NCT01373242 Phase 1, Phase 2 Liquid peanut extract (Peanut SLIT)
25 A Double-Blind, Placebo-Controlled Randomized Trial to Study the Viaskin Milk Efficacy and Safety for Treating IgE-Mediated Cow's Milk Allergy in Children Completed NCT02223182 Phase 1, Phase 2
26 The Persistence of Oral Tolerance Induction to Peanut and Its Immunological Basis (ITN049AD) Completed NCT01366846 Phase 2
27 FAST-Fish -Food Allergy Specific Treatment for Fish Allergy. Completed NCT02017626 Phase 1, Phase 2
28 Epicutaneous Immunotherapy (EPIT) for Peanut Allergy: A Randomized, Double-Blind, Placebo-Controlled, Phase II Study in Children and Adults (DAIT COFAR6) Completed NCT01904604 Phase 2
29 Dietary Intervention in Milk Allergy and Tolerance Development Completed NCT00778258 Phase 2
30 Oral Desensitization to Egg With Subsequent Induction of Tolerance for Egg-Allergic Children (CoFAR 3) Completed NCT00461097 Phase 2 Egg oral immunotherapy;Control Group
31 A Double-blinded, Placebo-controlled Study of Peanut Sublingual Immunotherapy in Children - DBPC Peanut SLIT Completed NCT00597727 Phase 2 Peanut SLIT;Placebo SLIT
32 Determining the Efficacy and Value of Immunotherapy on the Likelihood of Peanut Tolerance: The DEVIL Study; Grant "Optimizing Tolerance Induction in Peanut Allergy: The DEVIL Study" Completed NCT00932828 Phase 2 Peanut oral immunotherapy
33 A Randomized, Double-Blind, Placebo-Controlled Pilot Study of Sublingual/Oral Immunotherapy for the Treatment of Peanut Allergy Completed NCT01084174 Phase 1, Phase 2 Peanut powder;Peanut extract;Placebo extract;Placebo powder
34 Sublingual Immunotherapy for Peanut Allergy: A Randomized, Double-Blind, Placebo-Controlled, Phase I/II Pilot Study With a Whole Peanut Extract Completed NCT00580606 Phase 1, Phase 2 Glycerinated peanut allergenic extract;Placebo for peanut extract (glycerin)
35 Oral Immunotherapy for Peanut Allergy (2nd Generation PMIT Collaboration With Arkansas Children's) Completed NCT00597675 Phase 2
36 Mechanisms of Desensitization During Peanut Oral Immunotherapy Completed NCT01814241 Phase 2 Open label peanut OIT
37 An Investigation Into the Effectiveness of NAET on Autism Spectrum Disorders Completed NCT00247156 Phase 1, Phase 2
38 Preventing Life-Threatening Allergic Reactions With Acalabrutinib, an FDA-Approved Bruton's Tyrosine Kinase Inhibitor Recruiting NCT05038904 Phase 2 Acalabrutinib
39 Challenging to Food With Escalating Thresholds for Reducing Food Allergy Recruiting NCT03907397 Phase 2
40 Phase 2 Randomized Controlled Trial Using Biologics to Improve Multi OIT Outcomes Recruiting NCT03679676 Phase 2 Omalizumab;Dupilumab
41 A Randomised, Controlled Trial Evaluating the Effectiveness of Fish Oral Immunotherapy (FOIT) in Inducing Desensitisation or Remission in Children With Fish Allergy Compared With Placebo Recruiting NCT05590299 Phase 2
42 Pilot Study on Immunotherapy for the Treatment of Persistant Peanut Allergy Recruiting NCT04974970 Phase 1, Phase 2 Peanut Immunotherapy
43 Prospective Study to Identify Food-Specific and Component IgE Threshold Levels That Predict Food Allergy in Patients With Elevated Total Serum IgE Levels and Atopic Dermatitis Recruiting NCT03835767 Phase 2
44 A 15 Months, Double-Blind, Randomized Controlled Trial Comparing 20 Weeks of Two Dosages of Omalizumab to Placebo to Accelerate a Symptom-driven Oral Immunotherapy Schedule in Subjects Aged 6 to 25 Years With Multiple Food Allergies Recruiting NCT04045301 Phase 2
45 Low Dose Multi Allergen Oral Immunotherapy for Food Allergy Active, not recruiting NCT03799328 Phase 2
46 A Phase 1/2, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Efficacy and Safety of ADP101 for Oral Immunotherapy in Food-Allergic Children and Adults (The Harmony Study) Active, not recruiting NCT04856865 Phase 1, Phase 2
47 Phase 2 Study of Omalizumab in Oral Peanut Desensitization Active, not recruiting NCT01781637 Phase 1, Phase 2 Omalizumab;placebo
48 T Cell Reagent Research for Monitoring T Cells in Food Allergy (MOTIF) Phase 2 Study Using Food Allergen Oral Immunotherapy for Shrimp or Cashew Allergies Active, not recruiting NCT03504774 Phase 2 Cashew or Shrimp Oral Immunotherapy
49 An Open-Label Extension Study Evaluating the Safety and Efficacy of ADP101 for Oral Immunotherapy in Food-Allergic Children and Adults (The Encore Study) Enrolling by invitation NCT05243719 Phase 1, Phase 2
50 Subthreshold Peanut in Infants - Understanding Plasticity Withdrawn NCT04761835 Phase 2

Search NIH Clinical Center for Food Allergy

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Cromolyn
Cromolyn Sodium

Cochrane evidence based reviews: food hypersensitivity

Genetic Tests for Food Allergy

Anatomical Context for Food Allergy

Organs/tissues related to Food Allergy:

MalaCards : Skin, Tongue, T Cells, Breast, Small Intestine, B Cells, Bone Marrow

Publications for Food Allergy

Articles related to Food Allergy:

(show top 50) (show all 12272)
# Title Authors PMID Year
1
The Role of the Gallbladder, the Intestinal Barrier and the Gut Microbiota in the Development of Food Allergies and Other Disorders. 62 41
36430811 2022
2
The Role of the Gut Microbiome in Cow's Milk Allergy: A Clinical Approach. 62 41
36364799 2022
3
Early life environmental antibiotic exposure and preschool allergic diseases: A biomonitoring-based prospective study in eastern China. 41
36388395 2022
4
[Component-based diagnostic approach. Detection of sensitization to lipid transfer proteins in food allergy]. 53 62
20390241 2010
5
Confirmation of a predicted lack of IgE binding to Cry3Bb1 from genetically modified (GM) crops. 53 62
19818822 2010
6
The natural history of soy allergy. 53 62
20226303 2010
7
Anaphylaxis to wheat flour-derived foodstuffs and the lipid transfer protein syndrome: a potential role of wheat lipid transfer protein Tri a 14. 53 62
20016200 2010
8
Food allergy after liver transplantation in children: a prospective study. 53 62
19239659 2009
9
Usefulness of wheat and soybean specific IgE antibody titers for the diagnosis of food allergy. 53 62
19776678 2009
10
Food allergy among children in the United States. 53 62
19917585 2009
11
Component-resolved diagnosis of pollen allergy based on skin testing with profilin, polcalcin and lipid transfer protein pan-allergens. 53 62
19877313 2009
12
Is serum total IgE levels a good predictor of allergies in children? 53 62
19813686 2009
13
The non-specific lipid transfer protein, Ara h 9, is an important allergen in peanut. 53 62
19624524 2009
14
Maize food allergy: lipid-transfer proteins, endochitinases, and alpha-zein precursor are relevant maize allergens in double-blind placebo-controlled maize-challenge-positive patients. 53 62
19669736 2009
15
Management of cow's milk protein allergy in infants and young children: an expert panel perspective. 53 62
19702611 2009
16
The role of immunoglobulin E-binding epitopes in the characterization of food allergy. 53 62
19568005 2009
17
Elevation of plasma eotaxin levels in children with food allergy. 53 62
19564714 2009
18
Detection of IgE, IgG, IgA and IgM antibodies against raw and processed food antigens. 53 62
19435515 2009
19
EpidemAAITO: features of food allergy in Italian adults attending allergy clinics: a multi-centre study. 53 62
19220321 2009
20
Food allergy in Alergológica-2005. 53 62
19530417 2009
21
Cytokine profile in children with asthma undergoing food challenges. 53 62
19274928 2009
22
Is caesarean delivery associated with sensitization to food allergens and IgE-mediated food allergy: a systematic review. 53 62
19076564 2008
23
Helicobacter pylori as a protective factor against food allergy. 53 62
18758415 2008
24
Association factors for atopic dermatitis in nursery school children in Ishigaki islands - Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). 53 62
18693163 2008
25
The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy. 53 62
18502490 2008
26
The role of protein digestibility and antacids on food allergy outcomes. 53 62
18539189 2008
27
Asthma and food allergy. 53 62
18043270 2008
28
Confirmation of the association between high levels of immunoglobulin E food sensitization and eczema in infancy: an international study. 53 62
18028467 2008
29
Lupin sensitization and clinical allergy in food allergic children in Norway. 53 62
18076722 2008
30
The predictive value of specific immunoglobulin E levels for the first diagnosis of cow's milk allergy. A critical analysis of pediatric literature. 53 62
17651374 2007
31
Uveitis associated with immunoglobulin E-mediated allergic diseases. 53 62
17894692 2007
32
Hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age. 53 62
17498216 2007
33
Lipid transfer protein allergy: primary food allergy or pollen/food syndrome in some cases. 53 62
17489047 2007
34
Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene. 53 62
17484868 2007
35
Molecular characterisation of Lac s 1, the major allergen from lettuce (Lactuca sativa). 53 62
17349693 2007
36
Influence of the allelic variants encoded at the Gli-B1 locus, responsible for a major allergen of wheat, on IgE reactivity for patients suffering from food allergy to wheat. 53 62
17263477 2007
37
Thioredoxin and food allergy. 53 62
17141854 2007
38
ELISA method for monitoring human serum IgE specific for Cry1Ab introduced into genetically modified corn. 53 62
16982119 2007
39
Food allergy to proteins. 53 62
17245088 2007
40
Rice: another potential cause of food allergy in patients sensitized to lipid transfer protein. 53 62
17192718 2007
41
Wheat IgE-mediated food allergy in European patients: alpha-amylase inhibitors, lipid transfer proteins and low-molecular-weight glutenins. Allergenic molecules recognized by double-blind, placebo-controlled food challenge. 53 62
17496422 2007
42
[Contribution of indicators of sensitized T lymphocytes in the diagnosis of IgE independent and IgE dependent cow's allergy in children]. 53 62
17965461 2007
43
Netherton syndrome: report of identical twins presenting with severe atopic dermatitis. 53 62
16670861 2006
44
Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. 53 62
16815152 2006
45
Prevalence of elevated total IgE and food allergies in a consecutive series of ENT pediatric patients. 53 62
16564375 2006
46
Eosinophilic esophagitis. 53 62
16606552 2006
47
[Eosinophil cationic protein as a marker of eosinophil activity]. 53 62
17203813 2006
48
Measurements of eosinophil activation before and after food challenges in adults with food hypersensitivity. 53 62
16757922 2006
49
Sensitivity and specificity of food specific IgE and IgG determinations for the diagnosis of food allergy. 53 62
16673562 2006
50
Time course of total and food specific IgE antibodies (Rast Fx5) in the developing allergic child. 53 62
16285230 2005

Variations for Food Allergy

Expression for Food Allergy

Search GEO for disease gene expression data for Food Allergy.

Pathways for Food Allergy

Pathways related to Food Allergy according to GeneCards Suite gene sharing:

(show all 41)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.95 AOC1 CXCL8 EPX IFNG IL13 IL4
2
Show member pathways
13.51 CXCL8 IFNG IL13 IL4 IL4R IL5
3
Show member pathways
13.37 TNF STAT6 IL5 IL4R IL4 IL13
4
Show member pathways
13.3 TNF STAT6 IL5 IL4R IL4 IL13
5
Show member pathways
12.65 TNF STAT6 IL5 IL4R IL4 IL13
6 12.58 FOXP3 IFNG IL4 LGALS3 STAT6 TNF
7
Show member pathways
12.37 TNF IL4 IFNG CXCL8
8
Show member pathways
12.23 STAT6 IL4R IL4 IGHE
9
Show member pathways
12.13 IFNG IL4 IL5 TNF
10 12.1 TNF STAT6 IL4R IL4 IL13 IFNG
11 12.03 TNF LGALS3 IL4 IFNG CXCL8
12 11.99 TNF IL5 IL4 IFNG
13 11.94 TNF STAT6 IL4R IL4 IL13 CXCL8
14 11.84 IFNG IL13 IL4 IL5 TNF
15
Show member pathways
11.82 IL4R IL4 IFNG
16 11.81 IL5 IL4 IL13 IFNG CXCL8
17 11.77 CXCL8 FOXP3 IFNG IL13 IL4 IL5
18 11.75 STAT6 IL4R IL4 IFNG FOXP3
19 11.74 IL5 IL4 IFNG CXCL8
20 11.7 TNF IL4 IFNG
21 11.69 TNF IL5 IL4 IL13 CXCL8
22 11.67 STAT6 IL5 IL4R IL4
23
Show member pathways
11.64 TNF IFNG CXCL8
24
Show member pathways
11.62 TNF IL5 IL4 IFNG FOXP3 CXCL8
25 11.54 TNF IFNG CXCL8
26 11.54 TNF IL4R IL4 IFNG
27 11.5 STAT6 IL4R IL4
28 11.39 IL5 IL4R IL4 IFNG
29
Show member pathways
11.37 TNF IFNG FOXP3
30 11.31 TNF IL5 IL4 IL13 IFNG
31 11.27 IL5 IL4 IL13 IFNG
32 11.23 TNF IL5 IL4 IL13 IFNG
33 11.16 STAT6 IL5 IL4R IL4 IL13 IFNG
34 11.06 TNF IL5 IL4 IL13 IFNG CXCL8
35 11.02 STAT6 IL4R IL4
36
Show member pathways
11 TNF STAT6 IL5 IL4R IL4 IL13
37 10.98 TNF IL5 IL4 IL13 CXCL8
38 10.96 IL4R IL4 IFNG
39 10.84 IL13 IL4 IL4R IL5
40 10.67 IFNG FOXP3
41
Show member pathways
10.35 TNF CXCL8

GO Terms for Food Allergy

Cellular components related to Food Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 10.12 AOC1 CETP CSN1S1 CSN3 CXCL8 EPX
2 extracellular space GO:0005615 9.8 AOC1 CETP CSN1S1 CSN3 CXCL8 EPX

Biological processes related to Food Allergy according to GeneCards Suite gene sharing:

(show all 23)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.33 TNF IL4 IL13 IFNG FOXP3 CXCL8
2 positive regulation of cold-induced thermogenesis GO:0120162 10.13 STAT6 IL4R IL4 IL13
3 positive regulation of protein localization to plasma membrane GO:1903078 10.09 TNF LGALS3 IFNG
4 positive regulation of protein-containing complex assembly GO:0031334 10.08 TNF LGALS3 IFNG
5 positive regulation of B cell proliferation GO:0030890 10.05 IL5 IL4 IL13
6 positive regulation of chemokine production GO:0032722 10.04 IFNG IL4R TNF
7 immune response GO:0006955 9.97 TNF IL5 IL4R IL4 IL13 IGHE
8 defense response GO:0006952 9.96 TNF STAT6 EPX CXCL8
9 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.92 TNF IL4 IL13 IFNG
10 T-helper 2 cell differentiation GO:0045064 9.9 IL4R IL4
11 neuroinflammatory response GO:0150076 9.88 IL4 IFNG
12 positive regulation of immunoglobulin production GO:0002639 9.88 IL5 IL4R IL13
13 interleukin-4-mediated signaling pathway GO:0035771 9.85 STAT6 IL4R
14 negative regulation of chronic inflammatory response GO:0002677 9.84 IL4 FOXP3
15 isotype switching to IgE isotypes GO:0048289 9.81 FOXP3 STAT6
16 positive regulation of isotype switching to IgE isotypes GO:0048295 9.8 IL4 STAT6
17 positive regulation of nitrogen compound metabolic process GO:0051173 9.78 IFNG TNF
18 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.76 IFNG TNF
19 negative regulation of complement-dependent cytotoxicity GO:1903660 9.73 IL13 IL4
20 positive regulation of mast cell degranulation GO:0043306 9.73 IL13 IL4 IL4R
21 positive regulation of vitamin D biosynthetic process GO:0060557 9.67 TNF IFNG
22 positive regulation of mononuclear cell migration GO:0071677 9.43 TNF LGALS3 IL4
23 microglial cell activation GO:0001774 9.23 TNF IL4 IL13 IFNG

Molecular functions related to Food Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.36 TNF IL5 IL4 IL13 IFNG CXCL8

Sources for Food Allergy

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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