MCID: FDL002
MIFTS: 51

Food Allergy

Categories: Blood diseases, Immune diseases, Respiratory diseases

Aliases & Classifications for Food Allergy

MalaCards integrated aliases for Food Allergy:

Name: Food Allergy 12 42 15 17 71
Food Hypersensitivity 12 43
Food Allergies 15 62
Allergy Food 54

Classifications:



External Ids:

Disease Ontology 12 DOID:3044
MeSH 43 D005512
SNOMED-CT 67 414285001
UMLS 71 C0016470

Summaries for Food Allergy

MedlinePlus : 42 Food allergy is an abnormal response to a food triggered by your body's immune system. In adults, the foods that most often trigger allergic reactions include fish, shellfish, peanuts, and tree nuts, such as walnuts. Problem foods for children can include eggs, milk, peanuts, tree nuts, soy, and wheat. The allergic reaction may be mild. In rare cases it can cause a severe reaction called anaphylaxis. Symptoms of food allergy include Itching or swelling in your mouth Vomiting, diarrhea, or abdominal cramps and pain Hives or eczema Tightening of the throat and trouble breathing Drop in blood pressure Your health care provider may use a detailed history, elimination diet, and skin and blood tests to diagnose a food allergy. When you have food allergies, you must be prepared to treat an accidental exposure. Wear a medical alert bracelet or necklace, and carry an auto-injector device containing epinephrine (adrenaline). You can only prevent the symptoms of food allergy by avoiding the food. After you and your health care provider have identified the foods to which you are sensitive, you must remove them from your diet.

MalaCards based summary : Food Allergy, also known as food hypersensitivity, is related to fish allergy and aphthous stomatitis. An important gene associated with Food Allergy is CSN1S1 (Casein Alpha S1), and among its related pathways/superpathways are Innate Immune System and Akt Signaling. The drugs Montelukast and Omeprazole have been mentioned in the context of this disorder. Affiliated tissues include testes, skin and t cells, and related phenotypes are no phenotypic analysis and respiratory system

Disease Ontology : 12 A hypersensitivity reaction type I disease that is an abnormal response to a food, triggered by the body's immune system.

PubMed Health : 62 About food allergies: If someone keeps having the same reaction (e.g. nausea, a rash or feeling unwell) after eating certain foods, it may be logical to assume that they have a food allergy. But food allergies are actually less common than many people believe: The symptoms are often caused by something else instead. It’s important to get the right diagnosis in order to get the right treatment – and avoid removing certain foods from your diet for no reason.

Wikipedia : 74 A food allergy is an abnormal immune response to food. The symptoms of the allergic reaction may range... more...

Related Diseases for Food Allergy

Diseases related to Food Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 532)
# Related Disease Score Top Affiliating Genes
1 fish allergy 32.9 PVALB IGHE
2 aphthous stomatitis 32.9 TNF IL5 IL4 IL10
3 peanut allergy 32.8 IL5 IL4 IL13 IL10 IGHE FLG
4 egg allergy 32.8 IL5 IL4 IL13 IL10 IGHE FOXP3
5 esophagitis, eosinophilic, 1 32.7 STAT6 RNASE3 IL5 IL4 IL13 FLG
6 allergic asthma 32.5 STAT6 RNASE3 IL5 IL4 IL17A IL13
7 fruit allergy 32.3 SCP2 IL5 IL4 IL13 IL10 FOXP3
8 nut allergy 32.2 STAT6 SCP2 IL5 IL13 IGHE IGES
9 milk allergy 31.9 TNF STAT6 RNASE3 IL5 IL4 IL13
10 dermatitis, atopic 31.7 TNF STAT6 RNASE3 IL5 IL4 IL17A
11 dermatitis 31.7 TNF IL5 IL4 IL17A IL13 IL10
12 esophagitis 31.6 TNF IL5 IL4 IL13 IL10
13 exercise-induced anaphylaxis 31.6 IGHE FLG
14 diarrhea 31.4 TNF IL5 IL13 IL10 FOXP3
15 eosinophilic gastroenteritis 31.4 RNASE3 IL5 IL4 EPX
16 ige responsiveness, atopic 31.4 STAT6 RNASE3 IL5 IL4 IL13 IL10
17 cytokine deficiency 31.3 IL5 IL13
18 gastroesophageal reflux 31.3 TNF IL5 IL4 FOXP3
19 drug allergy 31.3 TPT1 IL5 IGHE
20 urticaria 31.3 TPT1 TNF RNASE3 IL5 IL4 IL13
21 gastroenteritis 31.1 TNF RNASE3 IL5 IL4 IL10 EPX
22 hypereosinophilic syndrome 31.1 RNASE3 IL5 IL4 IL13 IL10 IGHE
23 proctitis 30.9 TNF RNASE3 EPX
24 allergic rhinitis 30.9 TPT1 RNASE3 IL5 IL4 IL17A IL13
25 rubella 30.9 TNF IL5 IL4 IL10
26 idiopathic nephrotic syndrome 30.8 IL4 IGHE
27 contact dermatitis 30.8 TNF IL5 IL4 IL17A IL10 FLG
28 celiac disease 1 30.8 TNF IL5 IL4 IL17A IL13 IL10
29 pollen allergy 30.8 SCP2 RNASE3 IL5 IL13 IGHE FOXP3
30 purpura 30.7 TNF IL4 IL10
31 neurodermatitis 30.7 IL4 FLG
32 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 30.7 IL17A IL10 FOXP3
33 colitis 30.7 TNF IL4 IL17A IL13 IL10 FOXP3
34 rhinitis 30.6 TPT1 TNF RNASE3 IL5 IL4 IL17A
35 perinatal necrotizing enterocolitis 30.6 TNF IL10 CSN1S1
36 immune deficiency disease 30.6 TNF IL4 IL13 IL10 FOXP3
37 latex allergy 30.6 TNF RNASE3 IL5 IL4 IL13 IGHE
38 ulcerative colitis 30.6 TNF IL4 IL17A IL13 IL10
39 diphtheria 30.6 TNF IL5 IL4 IL13
40 peach allergy 30.6 SCP2 IGHE
41 crohn's disease 30.6 TNF IL4 IL17A IL10
42 arthritis 30.5 TNF IL4 IL17A IL13 IL10 FOXP3
43 otitis media 30.5 TNF RNASE3 IL5 IL4 IL17A IL13
44 stomatitis 30.5 TNF IL4 IL10
45 angioimmunoblastic lymphadenopathy with dysproteinemia 30.5 TNF IL5 IL13
46 cow milk allergy 30.5 TNF RNASE3 IL5 IL4 IL10 FOXP3
47 irritant dermatitis 30.5 TNF IL4 FLG
48 opisthorchiasis 30.5 TNF IL4 IGES
49 autoimmune enteropathy 30.5 IL17A FOXP3 CSN1S1
50 dermatitis herpetiformis 30.5 TNF IL5 IL4 IL17A IL10 FOXP3

Graphical network of the top 20 diseases related to Food Allergy:



Diseases related to Food Allergy

Symptoms & Phenotypes for Food Allergy

MGI Mouse Phenotypes related to Food Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 no phenotypic analysis MP:0003012 9.5 FOXP3 IL10 IL13 IL17A IL4 PVALB
2 respiratory system MP:0005388 9.23 FOXP3 IL10 IL13 IL17A IL4 IL5

Drugs & Therapeutics for Food Allergy

PubMed Health treatment related to Food Allergy: 62

The main thing people can do to prevent allergic reactions is avoid the food that causes them. Medication is generally only used in acute situations, if people have a more severe allergic reaction . It doesn’t tend to be used for the long-term treatment of food allergies . Anaphylactic reactions are treated using emergency kits. These contain medications to reduce severe allergic reactions and prevent them from getting worse.

Drugs for Food Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 215)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Montelukast Approved Phase 4 158966-92-8 5281040
2
Omeprazole Approved, Investigational, Vet_approved Phase 4 73590-58-6 4594
3
Mannitol Approved, Investigational Phase 4 69-65-8 6251 453
4
Fluticasone Approved, Experimental Phase 4 90566-53-3 62924
5
Omalizumab Approved, Investigational Phase 4 242138-07-4
6
BCG vaccine Investigational Phase 4
7 Mesalamine Phase 4 89-57-6
8 Calcium Supplement Phase 4
9 Anti-Inflammatory Agents, Non-Steroidal Phase 4
10 Adrenergic beta-Agonists Phase 4
11 Adrenergic alpha-Agonists Phase 4
12 Adrenergic Agents Phase 4
13 Vasoconstrictor Agents Phase 4
14 Adrenergic Agonists Phase 4
15 Mydriatics Phase 4
16 Sympathomimetics Phase 4
17 Neurotransmitter Agents Phase 4
18 Hormones Phase 4
19 Leukotriene Antagonists Phase 4
20 Antacids Phase 4
21 Anti-Ulcer Agents Phase 4
22 diuretics Phase 4
23 Vaccines Phase 4
24 Adjuvants, Immunologic Phase 4
25 Adrenocorticotropic Hormone Phase 4
26 Corticotropin-Releasing Hormone Phase 4
27 Anti-Allergic Agents Phase 4
28 Pharmaceutical Solutions Phase 4
29
Azithromycin Approved Phase 3 83905-01-5 447043 55185
30
Zinc Approved, Investigational Phase 3 7440-66-6 32051
31
Hydroxychloroquine Approved Phase 3 118-42-3 3652
32
Glutamic acid Approved, Nutraceutical Phase 3 56-86-0 33032
33
Ergocalciferol Approved, Nutraceutical Phase 3 50-14-6 5280793
34
Vitamin D3 Approved, Nutraceutical Phase 3 67-97-0 5280795 6221
35
Camostat Experimental Phase 3 59721-28-7
36 Antibodies, Monoclonal Phase 3
37 Serine Proteinase Inhibitors Phase 3
38
protease inhibitors Phase 3
39 HIV Protease Inhibitors Phase 3
40 Trypsin Inhibitors Phase 3
41 Ergocalciferols Phase 3
42 Vitamin D2 Phase 3
43 Nutrients Phase 3
44 Trace Elements Phase 3
45 Micronutrients Phase 3
46 Antirheumatic Agents Phase 3
47 Antiprotozoal Agents Phase 3
48 Antiparasitic Agents Phase 3
49 Antimalarials Phase 3
50
Serine Investigational, Nutraceutical Phase 3 56-45-1 5951

Interventional clinical trials:

(show top 50) (show all 396)
# Name Status NCT ID Phase Drugs
1 CLINICAL MANAGEMENT OF CHILDHOOD INTESTINAL LYMPHOID NODULAR HYPERPLASIA: A RANDOMIZED CONTROLLED CLINICAL TRIAL. Unknown status NCT01789294 Phase 4 Mesalamine
2 A Double Blind Placebo Controlled Randomised Trial to Study the Effects of Birch Pollen Specific Immunotherapy (BP-SIT) on the Symptoms of the Oral Allergy Syndrome in Adult Patients Unknown status NCT01431859 Phase 4
3 Phase 4 Study of Effects of Montelukast Treatment on Allergic Inflammation in Children With and Without Food Allergy, Single Centered, Randomised, Double Blind, Placebo Controlled Parallel Group Cross-over Study Completed NCT01618929 Phase 4 Montelukast
4 Integrated Approaches to Food Allergen and Allergy Risk Management: iFAAM: The Impact of Proton-pump Inhibitors (Antacids) on Threshold Dose Distributions Completed NCT02552537 Phase 4 Omeprazole;Placebo
5 Basophil Activation Test (BAT) Sensitivity in Child Food Allergy Completed NCT01966640 Phase 4
6 A Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Evaluate the Efficacy of Montelukast (Singulair) in Participants Ages 1 - 8 Years Diagnosed With Atopic Dermatitis Induced by Food Allergens Completed NCT00557284 Phase 4 Montelukast;Placebo
7 Pharmacokinetics of Intramuscular Adrenaline in Food--Allergic Teenagers: Does Dose Matter? Completed NCT03366298 Phase 4
8 Bacille Calmette Guérin Immunisation at Birth and Childhood Morbidity in Danish Children. A Prospective, Randomised, Clinical Trial. Completed NCT01694108 Phase 4
9 A Phase-IV, Open-label Study to Evaluate Safety/Tolerability of Once-daily AVAMYS (TM) Aqueous Nasal Spray 110mcg Among Vietnamese Adult Patients With Established Perennial Allergic Rhinitis (PAR) Completed NCT01270958 Phase 4 Avamys aqueous nasal spray 110mcg
10 Effects of an Association of the Two Bifidobacteria Probiotics Bifidobacterium Breve B632 and Bifidobacterium Breve BR03 in Intestinal Bacterial Colonization and in the Prevention and/or Reduction of the Incidence of Colics in Infants Completed NCT03219931 Phase 4 Bifidobacterium breve BR03 and Bifidobacterium breve B632;Placebos
11 The Effect of Corticotrophin-releasing Hormone (CRH) on Esophageal Motility in Healthy Volunteers Completed NCT02736734 Phase 4 CRH
12 Can Vitamin D Supplementation in Infants Prevent Food Allergy in the First Year of Life? The VITALITY Trial. Recruiting NCT02112734 Phase 4 Vitamin D;placebo
13 Protection From Food Induced Anaphylaxis by Reducing the Serum Level of Specific IgE (Protana). Recruiting NCT03964051 Phase 4 Omalizumab Injection
14 Treatment With Omalizumab in Food Allergic Children (TOFAC) Not yet recruiting NCT04037176 Phase 4 Omalizumab
15 Use of Probiotic Bacteria in Prevention of Allergic Disease in Children 1999-2008 Unknown status NCT00298337 Phase 2, Phase 3 Mixture of probiotic bacteria and prebiotic oligosaccharide
16 Parmigiano-Reggiano Cheese as a Possible Strategy of Immunonutrition Able to Stimulate the Acquisition of Oral Tolerance in Childre With Cow's Milk Allergy Unknown status NCT02081651 Phase 3
17 Real-World AR101 Market-Supporting Experience Study in Peanut-Allergic Children, Active Treatment Arm Open-Label Extension Study (RAMSES OLE) Completed NCT03337542 Phase 3
18 Effects of GOS/PDX Supplemented Formula in Preventing and Modifying the History of Allergy and Acute Infections in a Population of Infants at Risk of Atopy Completed NCT02116452 Phase 3
19 Development and Field Testing of Ready-to-use-therapeutic Foods Made of Local Ingredients in Bangladesh for the Treatment of Children With Severe Acute Malnutrition Completed NCT01889329 Phase 2, Phase 3
20 Efficacy of a New Hypotonic Oral Rehydration Solution Containing Zinc and Prebiotics in the Treatment of Children With Acute Diarrhea Completed NCT01025583 Phase 2, Phase 3
21 Omalizumab as Monotherapy and as Adjunct Therapy to Multi-Allergen Oral Immunotherapy (OIT) in Food Allergic Children and Adults (CoFAR-11) Recruiting NCT03881696 Phase 3 Omalizumab;Placebo for Omalizumab;Multi-Allergen Oral Immunotherapy;Placebo for Multi-Allergen Oral Immunotherapy
22 THE PEBBLES STUDY: A Randomised Controlled Trial to Prevent Eczema, Food Allergy and Sensitisation Using a Skin Barrier Improvement Strategy Recruiting NCT03667651 Phase 3 EpiCeram
23 An Open-Label Study to Compare the Efficacy, Safety, and Tolerability of Hydroxychloroquine Combined With Azithromycin Compared to Hydroxychloroquine Combined With Camostat Mesylate and to "no Treatment" in Hospitalized Patients Suffering From a Mild or Moderate SARS CoV 2 Virus Recruiting NCT04355052 Phase 3 hydroxychloroquine in combination with camostat mesylate;Hydroxychloroquine in combination of Azithromycin
24 Phase III Study of Metabolic Intervention With Glutamate in Coronary Surgery II Recruiting NCT02592824 Phase 3 glutamate infusion;saline infusion
25 Open-label Follow-up Study of the PEPITES Study to Evaluate the Long-term Efficacy and Safety of Viaskin Peanut Active, not recruiting NCT03013517 Phase 3 Viaskin Peanut 250µg
26 Randomized Trial: Maternal Vitamin D Supplementation to Prevent Childhood Asthma (VDAART) Active, not recruiting NCT00920621 Phase 3
27 A Randomised, Controlled Trial to Determine if BCG Immunisation at Birth Reduces Allergy and Infection in Infants Active, not recruiting NCT01906853 Phase 3
28 Efficacite et Innocuite du Tannate de Gelatine Dans le Traitement de la Diarrhee aiguë de l'Enfant. Une Etude Randomisee, Controlee, en Double Aveugle (INDIGO) Not yet recruiting NCT04065529 Phase 3
29 A Randomized, Double-blind, Placebo-controlled Trial to Assess the Efficacy and Safety of Oral Hydroxychloroquine for the Treatment of SARS-CoV-2 Positive Patients for the Prevention of Severe COVID-19 Disease. Suspended NCT04329611 Phase 3 Hydroxychloroquine
30 Investigation of the Efficacy of the Food Allergy Herbal Formula (FAHF-2TM) in Patients With Food Allergy - Phase II Trial Unknown status NCT00602160 Phase 2 FAHF-2 (TM)
31 The Effect of Extrinsic Factors on Food Allergy Unknown status NCT01429896 Phase 2
32 Clinical Desensitization and Tolerance Following Peanut Oral Immunotherapy and Subsequent Allergen Avoidance Unknown status NCT01750879 Phase 1, Phase 2 Peanut Flour;Oat Flour
33 Effectiveness and Efficacy of Zinc With Probiotics for the Treatment of Acute Diarrhea in Young Children Unknown status NCT01140074 Phase 2 Zinc Sulfate
34 Randomized, Controlled, Blinded, Pilot Study Using Xolair in Rush Multi Oral Immunotherapy in Multi Food Allergic Patients Completed NCT02643862 Phase 1, Phase 2 Xolair;Placebo
35 Oral Desensitization to Egg With Subsequent Induction of Sustained Unresponsiveness for Egg-Allergic Children Using Baked Egg or Egg Oral Immunotherapy (OIT) Completed NCT01846208 Phase 2 Egg Oral Immunotherapy;Baked Egg
36 Epicutaneous Immunotherapy (EPIT) for Peanut Allergy: A Randomized, Double-Blind, Placebo-Controlled, Phase II Study in Children and Adults (DAIT COFAR6) Completed NCT01904604 Phase 2
37 A Phase 2 Study Multi Oral Immunotherapy in Multi Food Allergic Patients to Test Tolerance M-TAX Study Completed NCT02626611 Phase 2 Omalizumab;Food Flour Buildup
38 A Phase 2 Study Multi Oral Immunotherapy in Multi Food Allergic Patients to Test Immune Markers After Minimum Maintenance Dose Completed NCT03181009 Phase 2 Omalizumab;Food Flour Allergens
39 Sublingual Immunotherapy for Peanut Allergy: A Randomized, Double-Blind, Placebo-Controlled, Phase I/II Pilot Study With a Whole Peanut Extract Completed NCT00580606 Phase 1, Phase 2 Glycerinated peanut allergenic extract;Placebo for peanut extract (glycerin)
40 Inhibition of Anaphylaxis by Ibrutinib Completed NCT03149315 Phase 2 Ibrutinib
41 Oral Desensitization to Egg With Subsequent Induction of Tolerance for Egg-Allergic Children (CoFAR 3) Completed NCT00461097 Phase 2 Egg oral immunotherapy;Control Group
42 Effects of Omalizumab on Peanut Allergen Induced Cellular and Clinical Responses in Peanut Allergic Adults Completed NCT00949078 Phase 2 omalizumab
43 Oral Immunotherapy for Wheat Allergy Completed NCT01980992 Phase 1, Phase 2 Wheat OIT
44 Pilot Study of Omalizumab in Eosinophilic Gastroenteritis Completed NCT00084097 Phase 2 Omalizumab
45 Dietary Intervention in Milk Allergy and Tolerance Development Completed NCT00778258 Phase 2
46 FAST-Fish -Food Allergy Specific Treatment for Fish Allergy. Completed NCT02017626 Phase 1, Phase 2
47 A Double-blinded, Placebo-controlled Study of Peanut Sublingual Immunotherapy in Children - DBPC Peanut SLIT Completed NCT00597727 Phase 2 Peanut SLIT;Placebo SLIT
48 Mechanisms of Desensitization During Peanut Oral Immunotherapy Completed NCT01814241 Phase 2 Open label peanut OIT
49 A Multinational Phase IIb Study to Investigate the Efficacy and Safety of Subcutaneous Immunotherapy With a Modified Fish- Parvalbumin Given in Single Rising and Maintenance Doses to Subjects Allergic to Fish Completed NCT02382718 Phase 2
50 Oral Immunotherapy for Peanut Allergy (2nd Generation PMIT Collaboration With Arkansas Children's) Completed NCT00597675 Phase 2

Search NIH Clinical Center for Food Allergy

Inferred drug relations via UMLS 71 / NDF-RT 50 :


Cromolyn
Cromolyn Sodium

Cochrane evidence based reviews: food hypersensitivity

Genetic Tests for Food Allergy

Anatomical Context for Food Allergy

MalaCards organs/tissues related to Food Allergy:

40
Testes, Skin, T Cells, Breast, Liver, B Cells, Colon

Publications for Food Allergy

Articles related to Food Allergy:

(show top 50) (show all 8826)
# Title Authors PMID Year
1
Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial. 42 61
32087121 2020
2
Molecular sensitization patterns in birch pollen-sensitized Korean children according to the presence of oral allergy syndrome. 42
32150106 2020
3
Challenges experienced with early introduction and sustained consumption of allergenic foods in the Enquiring About Tolerance (EAT) study: A qualitative analysis. 42
31812185 2019
4
[Component-based diagnostic approach. Detection of sensitization to lipid transfer proteins in food allergy]. 61 54
20390241 2010
5
Anaphylaxis to wheat flour-derived foodstuffs and the lipid transfer protein syndrome: a potential role of wheat lipid transfer protein Tri a 14. 61 54
20016200 2010
6
Food allergy after liver transplantation in children: a prospective study. 54 61
19239659 2009
7
Usefulness of wheat and soybean specific IgE antibody titers for the diagnosis of food allergy. 61 54
19776678 2009
8
Food allergy among children in the United States. 54 61
19917585 2009
9
Component-resolved diagnosis of pollen allergy based on skin testing with profilin, polcalcin and lipid transfer protein pan-allergens. 61 54
19877313 2009
10
Is serum total IgE levels a good predictor of allergies in children? 54 61
19813686 2009
11
The non-specific lipid transfer protein, Ara h 9, is an important allergen in peanut. 61 54
19624524 2009
12
Management of cow's milk protein allergy in infants and young children: an expert panel perspective. 61 54
19702611 2009
13
Maize food allergy: lipid-transfer proteins, endochitinases, and alpha-zein precursor are relevant maize allergens in double-blind placebo-controlled maize-challenge-positive patients. 61 54
19669736 2009
14
The role of immunoglobulin E-binding epitopes in the characterization of food allergy. 54 61
19568005 2009
15
Elevation of plasma eotaxin levels in children with food allergy. 61 54
19564714 2009
16
Detection of IgE, IgG, IgA and IgM antibodies against raw and processed food antigens. 61 54
19435515 2009
17
EpidemAAITO: features of food allergy in Italian adults attending allergy clinics: a multi-centre study. 61 54
19220321 2009
18
Food allergy in Alergológica-2005. 61 54
19530417 2009
19
Cytokine profile in children with asthma undergoing food challenges. 54 61
19274928 2009
20
Is caesarean delivery associated with sensitization to food allergens and IgE-mediated food allergy: a systematic review. 54 61
19076564 2008
21
Helicobacter pylori as a protective factor against food allergy. 61 54
18758415 2008
22
Association factors for atopic dermatitis in nursery school children in Ishigaki islands - Kyushu University Ishigaki Atopic Dermatitis Study (KIDS). 54 61
18693163 2008
23
The use of serum-specific IgE measurements for the diagnosis of peanut, tree nut, and seed allergy. 54 61
18502490 2008
24
The role of protein digestibility and antacids on food allergy outcomes. 61 54
18539189 2008
25
Lupin sensitization and clinical allergy in food allergic children in Norway. 54 61
18076722 2008
26
Confirmation of the association between high levels of immunoglobulin E food sensitization and eczema in infancy: an international study. 54 61
18028467 2008
27
Asthma and food allergy. 54 61
18043270 2008
28
The predictive value of specific immunoglobulin E levels for the first diagnosis of cow's milk allergy. A critical analysis of pediatric literature. 61 54
17651374 2007
29
Hypogammaglobulinaemia secondary to cow-milk allergy in children under 2 years of age. 54 61
17498216 2007
30
Uveitis associated with immunoglobulin E-mediated allergic diseases. 61 54
17894692 2007
31
Lipid transfer protein allergy: primary food allergy or pollen/food syndrome in some cases. 54 61
17489047 2007
32
Severe food allergy as a variant of IPEX syndrome caused by a deletion in a noncoding region of the FOXP3 gene. 61 54
17484868 2007
33
Thioredoxin and food allergy. 54 61
17141854 2007
34
Influence of the allelic variants encoded at the Gli-B1 locus, responsible for a major allergen of wheat, on IgE reactivity for patients suffering from food allergy to wheat. 61 54
17263477 2007
35
[Contribution of indicators of sensitized T lymphocytes in the diagnosis of IgE independent and IgE dependent cow's allergy in children]. 54 61
17965461 2007
36
Rice: another potential cause of food allergy in patients sensitized to lipid transfer protein. 54 61
17192718 2007
37
Wheat IgE-mediated food allergy in European patients: alpha-amylase inhibitors, lipid transfer proteins and low-molecular-weight glutenins. Allergenic molecules recognized by double-blind, placebo-controlled food challenge. 54 61
17496422 2007
38
Food allergy to proteins. 61 54
17245088 2007
39
Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects. 61 54
16815152 2006
40
Prevalence of elevated total IgE and food allergies in a consecutive series of ENT pediatric patients. 54 61
16564375 2006
41
Eosinophilic esophagitis. 61 54
16606552 2006
42
Sensitivity and specificity of food specific IgE and IgG determinations for the diagnosis of food allergy. 61 54
16673562 2006
43
Measurements of eosinophil activation before and after food challenges in adults with food hypersensitivity. 54 61
16757922 2006
44
[Eosinophil cationic protein as a marker of eosinophil activity]. 61 54
17203813 2006
45
Time course of total and food specific IgE antibodies (Rast Fx5) in the developing allergic child. 54 61
16285230 2005
46
Utility of the ratio of food-specific IgE/total IgE in predicting symptomatic food allergy in children. 61 54
15969684 2005
47
Controlled oral food challenges in children--when indicated, when superfluous? 61 54
15932374 2005
48
Epsilon germ-line and IL-4 transcripts are expressed in human intestinal mucosa and enhanced in patients with food allergy. 54 61
15876314 2005
49
Peanut- and cow's milk-specific IgE, Th2 cells and local anaphylactic reaction are induced in Balb/c mice orally sensitized with cholera toxin. 54 61
15813812 2005
50
Food allergen sensitization in inner-city children with asthma. 61 54
15867869 2005

Variations for Food Allergy

Expression for Food Allergy

Search GEO for disease gene expression data for Food Allergy.

Pathways for Food Allergy

Pathways related to Food Allergy according to GeneCards Suite gene sharing:

(show all 27)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.96 TNF STAT6 RNASE3 IL5 IL4 IL17A
2
Show member pathways
13.32 TNF STAT6 IL5 IL4 IL17A IL13
3
Show member pathways
13.29 TNF STAT6 IL5 IL4 IL17A IL13
4
Show member pathways
12.76 TNF RNASE3 IL5 IL4 IL17A IL13
5
Show member pathways
12.55 TNF IL5 IL4 IL17A IL10
6
Show member pathways
12.54 TNF STAT6 IL5 IL4 IL17A IL13
7
Show member pathways
12.53 TNF IL5 IL4 IL13 IGHE
8 12.52 TPT1 TNF STAT6 IL4 IL17A IL10
9
Show member pathways
12.4 STAT6 IL5 IL4 IL13 IL10
10
Show member pathways
12.29 TNF IL5 IL4 IL17A IL13
11
Show member pathways
12.22 TNF IL5 IL4 IL17A IL13 IL10
12 11.93 TNF IL5 IL4 IL10
13 11.8 TNF IL5 IL4
14
Show member pathways
11.73 TNF IL5 IL4 FOXP3
15 11.71 IL5 IL4 IL13
16 11.64 TNF IL5 IL4 IL17A IL13 IL10
17 11.63 STAT6 IL5 IL4 IL10 IGHE
18 11.62 TNF IL5 IL4 IL13
19 11.56 TNF STAT6 IL4 IL17A IL13 IL10
20 11.49 TNF IL4 IL13 IL10
21
Show member pathways
11.32 TNF IL10 FOXP3
22 11.22 TNF IL5 IL4 IL17A IL13
23 11.19 IL5 IL4 IL13 IL10
24 11.02 TNF IL5 IL4 IL13 IL10
25 10.96 TNF IL5 IL4 IL17A IL13 IL10
26 10.77 IL5 IL4 IL13
27 10.76 STAT6 IL5 IL4 IL13 IL10 FOXP3

GO Terms for Food Allergy

Cellular components related to Food Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.77 TNF RNASE3 IL5 IL4 IL17A IL13
2 extracellular space GO:0005615 9.44 TPT1 TNF RNASE3 IL5 IL4 IL17A

Biological processes related to Food Allergy according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cold-induced thermogenesis GO:0120162 9.83 STAT6 IL4 IL13
2 negative regulation of inflammatory response GO:0050728 9.8 IL4 IL13 IL10 FOXP3
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.79 TNF IL4 IL13
4 positive regulation of B cell proliferation GO:0030890 9.69 IL5 IL4 IL13
5 negative regulation of interleukin-10 production GO:0032693 9.65 FOXP3 EPX
6 positive regulation of chemokine biosynthetic process GO:0045080 9.65 TNF IL4
7 negative regulation of endothelial cell apoptotic process GO:2000352 9.65 IL4 IL13 IL10
8 macrophage activation GO:0042116 9.64 IL4 IL13
9 positive regulation of podosome assembly GO:0071803 9.64 TNF IL5
10 positive regulation of interleukin-10 secretion GO:2001181 9.63 IL4 IL13
11 positive regulation of mast cell degranulation GO:0043306 9.63 IL4 IL13
12 negative regulation of interleukin-6 production GO:0032715 9.63 TNF IL10 FOXP3
13 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.62 IL4 IL10
14 positive regulation of MHC class II biosynthetic process GO:0045348 9.62 IL4 IL10
15 negative regulation of T-helper 17 cell differentiation GO:2000320 9.61 IL4 FOXP3
16 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.6 TNF IL17A
17 endothelial cell apoptotic process GO:0072577 9.59 TNF IL10
18 positive regulation of mononuclear cell migration GO:0071677 9.58 TNF IL4
19 type 2 immune response GO:0042092 9.58 IL4 IL10
20 negative regulation of cytokine production involved in immune response GO:0002719 9.57 TNF IL10
21 negative regulation of interleukin-5 production GO:0032714 9.56 FOXP3 EPX
22 negative regulation of cytokine secretion involved in immune response GO:0002740 9.55 TNF IL10
23 defense response to bacterium GO:0042742 9.55 TNF RNASE3 IL10 IGHE EPX
24 regulation of isotype switching GO:0045191 9.54 IL4 IL10
25 negative regulation of chronic inflammatory response GO:0002677 9.52 IL4 FOXP3
26 positive regulation of JAK-STAT cascade GO:0046427 9.5 TNF IL5 IL10
27 immune response GO:0006955 9.5 TNF IL5 IL4 IL17A IL13 IL10
28 negative regulation of complement-dependent cytotoxicity GO:1903660 9.43 IL4 IL13
29 microglial cell activation GO:0001774 9.43 TNF IL4 IL13
30 positive regulation of isotype switching to IgE isotypes GO:0048295 9.4 STAT6 IL4
31 receptor biosynthetic process GO:0032800 9.37 TNF IL10
32 cytokine-mediated signaling pathway GO:0019221 9.23 TNF STAT6 IL5 IL4 IL17A IL13

Molecular functions related to Food Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TNF IL5 IL4 IL17A IL13 IL10

Sources for Food Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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