MCID: FDB001
MIFTS: 56

Foodborne Botulism

Categories: Eye diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Foodborne Botulism

MalaCards integrated aliases for Foodborne Botulism:

Name: Foodborne Botulism 12 12 53 59 15
Botulism 12 76 53 59 55 43 3 44 15
Wound Botulism 53 73
Intoxication with Clostridium Botulinum Toxin 12
Food Poisoning Due to Clostridium Botulinum 12
Infection Due to Clostridium Botulinum 12
Intoxication Botulism 59
Botulism, Infantile 73
Botulism Poisoning 12
Infant Botulism 53

Characteristics:

Orphanet epidemiological data:

59
foodborne botulism
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Romania); Age of onset: All ages; Age of death: any age;
botulism
Prevalence: <1/1000000 (Europe),<1/1000000 (Worldwide),1-9/1000000 (France),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:



Summaries for Foodborne Botulism

MedlinePlus : 43 Botulism is a rare but serious illness. The cause is a toxin (poison) made by a bacterium called Clostridium botulinum. It occurs naturally in soil. There are several kinds of botulism. Foodborne botulism comes from eating foods contaminated with the toxin. Wound botulism happens when a wound infected with the bacteria makes the toxin. It is more common in heroin users. Infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. All forms can be deadly and are medical emergencies. Symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. Treatment may include antitoxins, intensive medical care, or surgery of infected wounds. To prevent botulism: Be very careful when canning foods at home Do not let babies eat honey Get prompt medical care for infected wounds Centers for Disease Control and Prevention

MalaCards based summary : Foodborne Botulism, also known as botulism, is related to wound botulism and infant botulism. An important gene associated with Foodborne Botulism is SNAP25 (Synaptosome Associated Protein 25), and among its related pathways/superpathways are Uptake and actions of bacterial toxins and Delta508-CFTR traffic / Sorting endosome formation in CF. The drugs Botulinum Antitoxin and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include eye, testes and brain, and related phenotypes are ptosis and diplopia

Disease Ontology : 12 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located in neuromuscular junction resulting in descending muscle paralysis, has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F.

CDC : 3 Botulism is a rare but serious illness caused by a toxin that attacks the body’s nerves.

Wikipedia : 76 Botulism is a rare and potentially fatal illness caused by a toxin produced by the bacterium Clostridium... more...

Related Diseases for Foodborne Botulism

Diseases related to Foodborne Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 64)
# Related Disease Score Top Affiliating Genes
1 wound botulism 33.8 LY96 PAX3
2 infant botulism 32.8 BRD3 EEA1 LY96 SNAP25 SYT1 SYT2
3 intestinal botulism 12.6
4 adult intestinal botulism 12.4
5 inhalational botulism 12.3
6 iatrogenic botulism 12.3
7 toxin-mediated infectious botulism 12.2
8 sudden infant death syndrome 10.2
9 respiratory failure 10.1
10 presynaptic congenital myasthenic syndromes 10.1 SNAP25 SYT2
11 miller fisher syndrome 10.1
12 colitis 10.0
13 clostridium difficile colitis 10.0
14 cone-rod dystrophy 7 10.0 SNAP25 SYT1
15 lambert-eaton myasthenic syndrome 10.0
16 smallpox 10.0
17 staphyloenterotoxemia 10.0
18 spasticity 10.0
19 cardiac arrest 10.0
20 tetanus 10.0
21 cellulitis 10.0
22 cocaine abuse 10.0
23 dysphagia 10.0
24 head injury 10.0
25 alcohol-related birth defect 9.9 GP2 SNAP25 SV2C
26 down syndrome 9.9
27 enterocolitis 9.9
28 neuroblastoma 9.9
29 beriberi 9.9
30 cholera 9.9
31 bronchiolitis 9.9
32 hypotonia 9.9
33 fish-eye disease 9.8
34 ocular motor apraxia 9.8
35 asthma 9.8
36 acute leukemia 9.8
37 crohn's disease 9.8
38 gas gangrene 9.8
39 leukemia 9.8
40 sinusitis 9.8
41 thrombocytopenia 9.8
42 drug allergy 9.8
43 thrombosis 9.8
44 legionellosis 9.8
45 short bowel syndrome 9.8
46 brucellosis 9.8
47 pertussis 9.8
48 cat-scratch disease 9.8
49 tick paralysis 9.8
50 diphtheria 9.8

Graphical network of the top 20 diseases related to Foodborne Botulism:



Diseases related to Foodborne Botulism

Symptoms & Phenotypes for Foodborne Botulism

Human phenotypes related to Foodborne Botulism:

59 32 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 59 32 hallmark (90%) Very frequent (99-80%) HP:0000508
2 diplopia 59 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0000651
3 dysarthria 59 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0001260
4 dysphagia 59 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0002015
5 nausea and vomiting 59 32 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0002017
6 constipation 59 32 frequent (33%) Frequent (79-30%),Very frequent (99-80%) HP:0002019
7 respiratory insufficiency 59 32 frequent (33%) Frequent (79-30%) HP:0002093
8 cranial nerve paralysis 59 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0006824
9 fatigue 59 32 hallmark (90%) Very frequent (99-80%) HP:0012378
10 respiratory insufficiency due to muscle weakness 59 32 frequent (33%) Frequent (79-30%) HP:0002747
11 arrhythmia 59 32 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0011675
12 abdominal pain 59 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0002027
13 xerostomia 59 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0000217
14 diarrhea 59 32 occasional (7.5%) Occasional (29-5%),Very frequent (99-80%) HP:0002014
15 cerebral palsy 59 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0100021
16 diaphragmatic paralysis 59 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0006597
17 mydriasis 59 32 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0011499
18 urinary retention 59 32 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0000016
19 muscle flaccidity 59 32 hallmark (90%) Very frequent (99-80%) HP:0010547
20 cardiorespiratory arrest 59 32 occasional (7.5%) Occasional (29-5%) HP:0006543
21 muscle weakness 59 Very frequent (99-80%)
22 paralysis 59 Very frequent (99-80%)
23 diaphragmatic weakness 59 Occasional (29-5%)

MGI Mouse Phenotypes related to Foodborne Botulism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.1 GP2 HAS1 PAX3 SNAP25 SYT1 SYT2

Drugs & Therapeutics for Foodborne Botulism

Drugs for Foodborne Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Botulinum Antitoxin
2 Immunologic Factors
3 Antitoxins

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Botulism Outbreak in Thailand (Episode II) Completed NCT00348426 Botulinum AntiToxin

Search NIH Clinical Center for Foodborne Botulism

Cochrane evidence based reviews: botulism

Genetic Tests for Foodborne Botulism

Anatomical Context for Foodborne Botulism

MalaCards organs/tissues related to Foodborne Botulism:

41
Eye, Testes, Brain, Colon

Publications for Foodborne Botulism

Articles related to Foodborne Botulism:

(show top 50) (show all 377)
# Title Authors Year
1
Foodborne botulism due to ingestion of home-canned green beans: two case reports. ( 29301587 )
2018
2
Adult Intestinal Botulism: A Rare Presentation in an Immunocompromised Patient With Short Bowel Syndrome. ( 30225463 )
2018
3
Tetanus, Botulism, and Diphtheria. ( 30273248 )
2018
4
Foodborne botulism in Poland in 2016 ( 30111083 )
2018
5
Foodborne botulism: an evolving public health challenge. ( 30499356 )
2018
6
Guillain-Barré syndrome mimicking botulism in early disease course. ( 30061335 )
2018
7
Electrophysiological abnormalities in iatrogenic botulism: Two case reports and review of the literature. ( 30348587 )
2018
8
Notes from the Field: Intestinal Colonization and Possible Iatrogenic Botulism in Mouse Bioassay-Negative Serum Specimens - Los Angeles County, California, November 2017. ( 30383741 )
2018
9
Question 1: In infant botulism, is equine-derived botulinum antitoxin (EqBA) an effective alternative therapy to human-derived botulinum immune globulin (BIG)? ( 30007943 )
2018
10
Antimicrobial Susceptibility of 260 Clostridium botulinum Type A, B, Ba, and Bf Strains and a Neurotoxigenic Clostridium baratii Type F Strain Isolated from California Infant Botulism Patients. ( 30275093 )
2018
11
Identification and characterization of Clostridium botulinum strains associated with an infant botulism case in China. ( 30401636 )
2018
12
Is black tar heroin use associated with wound botulism? A report of two Hispanic patients. ( 29988706 )
2018
13
A pragmatic harm reduction approach to manage a large outbreak of wound botulism in people who inject drugs, Scotland 2015. ( 29996865 )
2018
14
Wound botulism caused by Clostridium subterminale after a heroin injection. ( 30344967 )
2018
15
Type C botulism outbreak in feedlot cattle fed contaminated corn silage. ( 30408576 )
2018
16
Botulism in the ICU: Nursing care plan. ( 29277396 )
2018
17
Enhancing toxin-based vaccines against botulism. ( 29307477 )
2018
18
Minimizing an outbreak of avian botulism (Clostridium botulinum type C) in Incheon, South Korea. ( 29375088 )
2018
19
A Novel Rabbit Spirometry Model of Type E Botulism and Its Use for the Evaluation of Postsymptom Antitoxin Efficacy. ( 29437616 )
2018
20
Botulism in pregnancy - a clinical approach to diagnosis and management. ( 29577785 )
2018
21
Botulism-like symptoms in an immunocompetent patient with Clostridium subterminale bacteremia. ( 29619329 )
2018
22
Type C botulism in domestic chickens, dogs and black-pencilled marmoset (Callithrix penicillata) in Minas Gerais, Brazil. ( 29621603 )
2018
23
The Short-Lived Epidemic of Botulism From Commercially Canned Foods in the United States, 1919 to 1925. ( 29677267 )
2018
24
An ambient temperature-stable antitoxin of nine co-formulated antibodies for botulism caused by serotypes A, B and E. ( 29746518 )
2018
25
Studying the differential efficacy of postsymptom antitoxin treatment in type A versus type B botulism using a rabbit spirometry model. ( 30115749 )
2018
26
Type C/D botulism in the waterfowl in an urban park in Italy. ( 30118893 )
2018
27
Clinical analysis of 86 botulism cases caused by cosmetic injection of botulinum toxin (BoNT). ( 30142749 )
2018
28
Botulism Outbreak in a Regional Community Hospital: Lessons Learned in Transfer and Transport Considerations. ( 30183447 )
2018
29
Immunogenicity of a Bivalent Non-Purified Recombinant Vaccine against Botulism in Cattle. ( 30241350 )
2018
30
Botulism in farmed ducks and pheasants. ( 30315061 )
2018
31
Type B botulism in a Korean couple after eating homemade doenjang. ( 30451029 )
2018
32
In response to "Botulism in pregnancy - a clinical approach to diagnosis and management" published on 25 March issue. ( 30453798 )
2018
33
Brain functional changes in patients with botulism after illegal cosmetic injections of botulinum toxin: A resting-state fMRI study. ( 30485326 )
2018
34
Foodborne botulism in the Faroe Islands in a two-decade period. ( 28597722 )
2017
35
Foodborne botulism in Poland in 2015 ( 29182078 )
2017
36
Foodborne Botulism, I Only Had Nacho Cheese: A Case Report. ( 29152423 )
2017
37
Efficacy of Antitoxin Therapy in Treating Patients With Foodborne Botulism: A Systematic Review and Meta-analysis of Cases, 1923-2016. ( 29293927 )
2017
38
The Epidemiology of Foodborne Botulism Outbreaks: A Systematic Review. ( 29293934 )
2017
39
Outbreak of Foodborne Botulism in an Immigrant Community: Overcoming Delayed Disease Recognition, Ambiguous Epidemiologic Links, and Cultural Barriers to Identify the Cause. ( 29293929 )
2017
40
Workgroup Report by the Joint Task Force Involving American Academy of Allergy, Asthma & Immunology (AAAAI); Food Allergy, Anaphylaxis, Dermatology and Drug Allergy (FADDA) (Adverse Reactions to Foods Committee and Adverse Reactions to Drugs, Biologicals, and Latex Committee); and the Centers for Disease Control and Prevention Botulism Clinical Treatment Guidelines Workgroup-Allergic Reactions to Botulinum Antitoxin: A Systematic Review. ( 29293931 )
2017
41
Immunoproteomics Approach for Screening of Vaccine Candidates against Intestinal Botulism. ( 28393685 )
2017
42
Effective and rapid treatment of wound botulism, a case report. ( 29073888 )
2017
43
Clinical Features of Foodborne and Wound Botulism: A Systematic Review of the Literature, 1932-2015. ( 29293923 )
2017
44
Recombinant Botulinum Neurotoxin Hc Subunit (BoNT Hc) and Catalytically Inactive Clostridium botulinum Holoproteins (ciBoNT HPs) as Vaccine Candidates for the Prevention of Botulism. ( 28869522 )
2017
45
Complete paralytic botulism mimicking a deep coma in a child. ( 29745121 )
2017
46
A large outbreak of bovine botulism possibly linked to a massive contamination of grass silage by type D/C Clostridium botulinum spores on a farm with dairy and poultry operations. ( 29094676 )
2017
47
Botulism outbreak causes high mortality in Scottish cattle. ( 29127172 )
2017
48
Therapeutic efficacy of equine botulism antitoxin in Rhesus macaques. ( 29166654 )
2017
49
Pediatric Botulism and Use of Equine Botulinum Antitoxin in Children: A Systematic Review. ( 29293924 )
2017
50
Botulism During Pregnancy and the Postpartum Period: A Systematic Review. ( 29293925 )
2017

Variations for Foodborne Botulism

Expression for Foodborne Botulism

Search GEO for disease gene expression data for Foodborne Botulism.

Pathways for Foodborne Botulism

GO Terms for Foodborne Botulism

Cellular components related to Foodborne Botulism according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 cell junction GO:0030054 9.8 SNAP25 SV2C SYT1 SYT2
2 cytoplasmic vesicle GO:0031410 9.73 EEA1 SV2C SYT1 SYT2
3 axon GO:0030424 9.69 SNAP25 SYT1 SYT2
4 presynaptic membrane GO:0042734 9.52 SNAP25 SYT1
5 SNARE complex GO:0031201 9.48 SNAP25 SYT1
6 clathrin-coated vesicle membrane GO:0030665 9.46 SYT1 SYT2
7 synaptic vesicle membrane GO:0030672 9.43 SV2C SYT1 SYT2
8 integral component of synaptic vesicle membrane GO:0030285 9.4 SV2C SYT1
9 exocytic vesicle GO:0070382 9.37 SYT1 SYT2
10 synapse GO:0045202 9.35 EEA1 SNAP25 SV2C SYT1 SYT2
11 dense core granule GO:0031045 9.32 SYT1 SYT2
12 chromaffin granule membrane GO:0042584 9.16 SYT1 SYT2
13 synaptic vesicle GO:0008021 8.92 SNAP25 SV2C SYT1 SYT2

Biological processes related to Foodborne Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.63 SNAP25 SV2C SYT1
2 cellular response to calcium ion GO:0071277 9.48 SYT1 SYT2
3 synaptic vesicle endocytosis GO:0048488 9.43 SYT1 SYT2
4 regulation of dopamine secretion GO:0014059 9.4 SYT1 SYT2
5 vesicle fusion GO:0006906 9.37 EEA1 SNAP25
6 calcium ion regulated exocytosis GO:0017156 9.32 SYT1 SYT2
7 positive regulation of dendrite extension GO:1903861 9.26 SYT1 SYT2
8 calcium ion-regulated exocytosis of neurotransmitter GO:0048791 9.16 SYT1 SYT2
9 neurotransmitter secretion GO:0007269 9.13 SNAP25 SYT1 SYT2
10 synaptic vesicle exocytosis GO:0016079 8.8 SNAP25 SYT1 SYT2

Molecular functions related to Foodborne Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-dependent protein binding GO:0048306 9.43 SNAP25 SYT1
2 SNARE binding GO:0000149 9.4 SYT1 SYT2
3 calcium-dependent phospholipid binding GO:0005544 9.37 SYT1 SYT2
4 phosphatidylserine binding GO:0001786 9.32 SYT1 SYT2
5 clathrin binding GO:0030276 9.26 SYT1 SYT2
6 syntaxin-1 binding GO:0017075 9.16 SNAP25 SYT1
7 1-phosphatidylinositol binding GO:0005545 8.96 EEA1 SYT1
8 syntaxin binding GO:0019905 8.8 SNAP25 SYT1 SYT2

Sources for Foodborne Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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