MCID: FDB001
MIFTS: 55

Foodborne Botulism

Categories: Eye diseases, Infectious diseases, Muscle diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Foodborne Botulism

MalaCards integrated aliases for Foodborne Botulism:

Name: Foodborne Botulism 12 12 20 58 15
Botulism 12 73 20 58 54 42 3 44 15 17 32
Wound Botulism 20 70
Intoxication with Clostridium Botulinum Toxin 12
Food Poisoning Due to Clostridium Botulinum 12
Infection Due to Clostridium Botulinum 12
Intoxication Botulism 58
Botulism, Infantile 70
Botulism Poisoning 12
Infant Botulism 20

Characteristics:

Orphanet epidemiological data:

58
foodborne botulism
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Romania); Age of onset: All ages; Age of death: any age;
botulism
Prevalence: <1/1000000 (Europe),<1/1000000 (Worldwide),1-9/1000000 (France),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050352 DOID:11976
MeSH 44 D001906
NCIt 50 C84599
SNOMED-CT 67 154276003
ICD10 32 A05.1
MESH via Orphanet 45 D001906
ICD10 via Orphanet 33 A05.1
UMLS via Orphanet 71 C0006057 C1739094
UMLS 70 C0006057 C0238027 C1306794

Summaries for Foodborne Botulism

MedlinePlus : 42 Botulism is a rare but serious illness. The cause is a toxin (poison) made by a bacterium called Clostridium botulinum. It occurs naturally in soil. There are several kinds of botulism. Foodborne botulism comes from eating foods contaminated with the toxin. Wound botulism happens when a wound infected with the bacteria makes the toxin. It is more common in heroin users. Infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. All forms can be deadly and are medical emergencies. Symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. Treatment may include antitoxins, intensive medical care, or surgery of infected wounds. To prevent botulism: Be very careful when canning foods at home Do not let babies eat honey Get prompt medical care for infected wounds Centers for Disease Control and Prevention

MalaCards based summary : Foodborne Botulism, also known as botulism, is related to wound botulism and intestinal botulism. An important gene associated with Foodborne Botulism is SNAP25 (Synaptosome Associated Protein 25), and among its related pathways/superpathways are HIV Life Cycle and Neuroscience. The drugs Botulinum Antitoxin and Antitoxins have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and spinal cord, and related phenotypes are ptosis and diplopia

Disease Ontology : 12 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located in neuromuscular junction resulting in descending muscle paralysis, has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F.

CDC : 3 Botulism is a rare but serious illness caused by a toxin that attacks the body's nerves.

Wikipedia : 73 Botulism is a rare and potentially fatal illness caused by a toxin produced by the bacterium Clostridium... more...

Related Diseases for Foodborne Botulism

Diseases related to Foodborne Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 185)
# Related Disease Score Top Affiliating Genes
1 wound botulism 31.9 VAPA VAMP2 VAMP1 SV2A GPA33 DENND11
2 intestinal botulism 29.6 SYT2 SV2C SV2A GPA33 BRD3
3 infant botulism 28.7 VAPA VAMP4 VAMP2 VAMP1 SYT2 SV2C
4 adult intestinal botulism 11.3
5 inhalational botulism 11.2
6 iatrogenic botulism 11.2
7 toxin-mediated infectious botulism 11.1
8 respiratory failure 10.4
9 sudden infant death syndrome 10.4
10 dysphagia 10.3
11 ptosis 10.3
12 constipation 10.3
13 kearns-sayre syndrome 10.2
14 anismus 10.2 VAPA SNAP25
15 diphtheria 10.2
16 detrusor sphincter dyssynergia 10.2 SV2A SNAP25
17 ileus 10.2
18 poliomyelitis 10.1
19 alcohol-related birth defect 10.1 SV2C SV2A
20 aspiration pneumonia 10.1
21 spinal muscular atrophy 10.1
22 muscular atrophy 10.1
23 spasticity 10.1
24 presynaptic congenital myasthenic syndromes 10.1 VAMP1 SYT2 SNAP25
25 myasthenic syndrome, congenital, 19 10.1 SYT2 SNAP25
26 disease by infectious agent 10.1
27 tetanus 10.1
28 lambert-eaton myasthenic syndrome 10.1
29 dystonia 10.1
30 benign familial infantile epilepsy 10.1 SYT2 SYT1 SNAP25
31 colitis 10.0
32 clostridium difficile colitis 10.0
33 urinary tract infection 10.0
34 miller fisher syndrome 10.0
35 gastroenteritis 10.0
36 anthrax disease 10.0
37 autoimmune disease 10.0
38 craniofacial-deafness-hand syndrome 10.0
39 lambert syndrome 10.0
40 myasthenia gravis 10.0
41 ocular motor apraxia 10.0
42 cardiac arrest 10.0
43 tick paralysis 10.0
44 allergic disease 10.0
45 guillain-barre syndrome 10.0
46 cranial nerve palsy 10.0
47 paralytic ileus 10.0
48 autonomic dysfunction 10.0
49 hypotonia 10.0
50 kagami-ogata syndrome 10.0 VAMP2 SYT2 SYT1

Graphical network of the top 20 diseases related to Foodborne Botulism:



Diseases related to Foodborne Botulism

Symptoms & Phenotypes for Foodborne Botulism

Human phenotypes related to Foodborne Botulism:

58 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000508
2 diplopia 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0000651
3 dysarthria 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0001260
4 dysphagia 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0002015
5 constipation 58 31 frequent (33%) Frequent (79-30%),Very frequent (99-80%) HP:0002019
6 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
7 cranial nerve paralysis 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0006824
8 abdominal pain 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0002027
9 cerebral palsy 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0100021
10 diaphragmatic paralysis 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0006597
11 diarrhea 58 31 occasional (7.5%) Occasional (29-5%),Very frequent (99-80%) HP:0002014
12 xerostomia 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0000217
13 muscle flaccidity 58 31 hallmark (90%) Very frequent (99-80%) HP:0010547
14 mydriasis 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0011499
15 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0002017
16 respiratory insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0002093
17 respiratory insufficiency due to muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0002747
18 arrhythmia 58 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0011675
19 urinary retention 58 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0000016
20 cardiorespiratory arrest 58 31 occasional (7.5%) Occasional (29-5%) HP:0006543
21 muscle weakness 58 Very frequent (99-80%)
22 diaphragmatic weakness 58 Occasional (29-5%)
23 paralysis 58 Very frequent (99-80%)

MGI Mouse Phenotypes related to Foodborne Botulism:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.23 GP2 SNAP25 SV2A SV2B SYT1 SYT2

Drugs & Therapeutics for Foodborne Botulism

Drugs for Foodborne Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Botulinum Antitoxin Phase 4
2 Antitoxins Phase 4
3
Amifampridine Approved, Investigational Phase 2, Phase 3 54-96-6 5918
4 Potassium Channel Blockers Phase 2, Phase 3
5
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
6 Immunoglobulins Phase 2
7 Antibodies Phase 2
8 Immunologic Factors Phase 2
9 Antibodies, Monoclonal Phase 1
10
Acetylcholine Approved, Investigational 51-84-3 187
11 Immunoglobulins, Intravenous
12 gamma-Globulins
13 Rho(D) Immune Globulin
14 incobotulinumtoxinA
15 Botulinum Toxins
16 Neurotransmitter Agents
17 Cholinergic Agents

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Pharmacokinetics of Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G) - (Equine) (BAT™) in Pediatric Patients With a Confirmed or Suspected Exposure to Botulinum Toxin. Completed NCT02051062 Phase 4
2 Pilot Study on the Usefulness of 3,4-diaminopyridine in the Treatment of Botulism Completed NCT01441557 Phase 2, Phase 3 3,4-diaminopyridine
3 A Phase 3, Double Blind, Placebo Controlled, Randomized, Multicenter Clinical Trial to Demonstrate the Safety, Lot Consistency and Clinical Benefit of Recombinant Botulinum Vaccine A/B (rBV A/B) Withdrawn NCT01940315 Phase 3
4 Tolerability and Immunogenicity of a Single 40-µg Dose of Recombinant Botulinum Vaccine A/B (rBV A/B) for the Production of BabyBIG® in Volunteers With Existing Botulinum Immunity Completed NCT03676634 Phase 2
5 Phase 2b, Two-part, Open-label, Uncontrolled Study to Evaluate Safety, Tolerability, and Immunogenicity of a Single 40-µg Dose of Recombinant Botulinum Vaccine A/B (rBV A/B) for the Production of BabyBIG® in Volunteers Previously Immunized With Pentavalent Botulinum Toxoid for Occupational Protection Completed NCT01701999 Phase 2
6 A Phase 2, Randomized, Double Blind, Placebo-Controlled, Multicenter Study to Evaluate Safety, Dosing Schedule and Antibody Kinetics of Recombinant Botulinum Vaccine A/B, rBV A/B-40, in Healthy Adults Completed NCT00764634 Phase 2
7 Botulism Antitoxin Effects on Paralysis Induced by Type A and Type B Botulinum Neurotoxins in the Extensor Digitorum Brevis Muscle Completed NCT00636519 Phase 1
8 Evaluation of the Improvement of Quality of Life of Patients Suffering From Hailey Hailey or Darier Disease After Injections of Botulism Toxin Into Large Folds. Toxin Hailey Darier Completed NCT02782702 Phase 1 Botulism Toxin Treatment
9 A Phase I, Double-Blind, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of NTM-1633 vs Placebo Administered Intravenously in Healthy Adults Completed NCT03603665 Phase 1
10 A Phase I, Double-Blind, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of NTM-1632 vs Placebo Administered Intravenously in Healthy Adults Completed NCT02779140 Phase 1
11 A Phase I, Blinded, Placebo-controlled, Dose-escalation Study of the Safety and Pharmacokinetics of XOMA 3AB Administered Intravenously in Healthy Adults Completed NCT01357213 Phase 1 XOMA 3AB
12 A Phase 1, Randomized, Double-Blind, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of a Single IM Dose of G03-52-01 vs Placebo in Adult Subjects Active, not recruiting NCT04171115 Phase 1 G03-52-01;Placebo
13 Study of Human Botulism Immunoglobulin in Infants With Botulism Completed NCT00004401 botulism immune globulin
14 Retrospective Epidemiological Study on Patients Admitted for Botulism Poisoning in Intensive Care Units in France Completed NCT03658902
15 Clinical Manifestations of Botulism Outbreak in Northern Thailand: A Case Series of Botulism Treated With Botulinum Anti-Toxin. Completed NCT00348426 Botulinum AntiToxin
16 An Outbreak of Botulism in Thailand: Clinical Manifestations and Management of Severe Respiratory Failure Completed NCT00314080 Botulinum AntiToxin
17 The Pilot Study of Constraint Induced Movement Therapy(CIMT) Intervention in Children With Hemiplegic Cerebral Palsy After Botulism Toxin Injection in Preschool Education Completed NCT04179682
18 Botulinum Antitoxin Patient Registry for the Evaluation of Safety and Clinical Outcomes of Pediatric and Adult Patients Following BAT Treatment for Confirmed or Suspected Exposure to Botulinum Toxin. Completed NCT02055183 BAT
19 Using Shear Wave Ultrasound Elastography for Follow up After Anti-spastic Intervention Among Stroke Patients Not yet recruiting NCT04550793 Botulinum toxin injection

Search NIH Clinical Center for Foodborne Botulism

Cochrane evidence based reviews: botulism

Genetic Tests for Foodborne Botulism

Anatomical Context for Foodborne Botulism

MalaCards organs/tissues related to Foodborne Botulism:

40
Eye, Brain, Spinal Cord, Skin, Breast, Colon, Bone Marrow

Publications for Foodborne Botulism

Articles related to Foodborne Botulism:

(show top 50) (show all 3330)
# Title Authors PMID Year
1
Production and characterization of a neutralizing antibody against botulinum neurotoxin A. 42 61
33007319 2020
2
Foodborne Botulism: Clinical Diagnosis and Medical Treatment. 61 42
32784744 2020
3
Characterization of immune response induced against catalytic domain of botulinum neurotoxin type E. 42 61
32811892 2020
4
Rescue of exocytosis in botulinum toxin A-poisoned chromaffin cells by expression of cleavage-resistant SNAP-25. Identification of the minimal essential C-terminal residues. 54 61
10601242 1999
5
Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds. 61 54
8243676 1993
6
Botulism-like Syndrome following Botulinum-A Injection for Hyperhidrosis and Fluroquinolone Use. 61
33685543 2021
7
Beating botulism with botulism. 61
33594281 2021
8
Re: The dilemma of diagnosing wound botulism in an infant. 61
33340665 2021
9
First confirmed case of infant botulism in Africa, caused by a dual-toxin-producing Clostridium botulinum strain. 61
33212262 2021
10
Open Tibial Fracture Complicated by Wound Botulism: A Case Study. 61
33653654 2021
11
Immunoproteomic analysis of Clostridium botulinum type B secretome for identification of immunogenic proteins against botulism. 61
33629143 2021
12
Discovery of Dipeptides as Potent Botulinum Neurotoxin A Light-Chain Inhibitors. 61
33603978 2021
13
New approach for the rational selection of markers to identify botulinum toxins. 61
33569691 2021
14
Profiling gene expression reveals insights into pulmonary response to aerosolized botulinum toxin type A exposure in mice. 61
33529366 2021
15
Foodborne botulism presenting as small bowel obstruction: a case report. 61
33435866 2021
16
A Monoclonal Antibody Combination against both Serotypes A and B Botulinum Toxin Prevents Inhalational Botulism in a Guinea Pig Model. 61
33466411 2021
17
Decoy toxin harnessed to fight botulism. 61
33414201 2021
18
Delivery of single-domain antibodies into neurons using a chimeric toxin-based platform is therapeutic in mouse models of botulism. 61
33408184 2021
19
Modification and validation of the Endopep-mass spectrometry method for botulinum neurotoxin detection in liver samples with application to samples collected during animal botulism outbreaks. 61
33119784 2021
20
Foodborne botulism: a case report. 61
33532656 2021
21
Neuronal delivery of antibodies has therapeutic effects in animal models of botulism. 61
33408188 2021
22
Complete Genome Sequence of Clostridium botulinum CJ0611A1, a Type A(B) Isolate Associated with an International Outbreak of Botulism from Commercial Carrot Juice. 61
33414295 2021
23
Occupations at risk of contracting zoonoses of public health significance in Québec. 61
33679248 2021
24
Spasticity in practice (SPACE): an international non-interventional study of botulinum neurotoxin type A in treatment-naïve subjects with spasticity. 61
33433902 2021
25
Botulinum Neurotoxins: Mechanism of Action. 61
32277300 2021
26
An Outbreak of Botulinum Types A, B, and E Associated With Vacuum-Packaged Salted Fish and Ham. 61
33518376 2021
27
CRISPR-Cas9-Based Toolkit for Clostridium botulinum Group II Spore and Sporulation Research. 61
33584620 2021
28
The Distinctive Evolution of orfX Clostridium parabotulinum Strains and Their Botulinum Neurotoxin Type A and F Gene Clusters Is Influenced by Environmental Factors and Gene Interactions via Mobile Genetic Elements. 61
33716993 2021
29
Novel Native and Engineered Botulinum Neurotoxins. 61
32274579 2021
30
Recent progress in nanomaterial-based sensing of airborne viral and bacterial pathogens. 61
33113463 2021
31
Botulinum Toxin in WW2 German and Allied Armies: Failures and Myths of Weaponization. 61
33472198 2021
32
Seven-Year Case-Control Study in California of Risk Factors for Infant Botulism. 61
32645406 2020
33
Descriptive Epidemiology of Infant Botulism in California: The First 40 Years. 61
32800814 2020
34
BOTOX injection to treat strabismus after infant botulism type B infection. 61
32923741 2020
35
Foodborne Botulism in Ukraine from 1955 to 2018. 61
33332209 2020
36
Prevalence, Risk Factors, and Epidemiology of Food-borne Botulism in Iran. 61
32959610 2020
37
Assessing Preference in a Paired-Stimulus Arrangement with Captive Vultures (Aegypius Monachus). 61
33305965 2020
38
The whole truth about botulinum toxin - a review. 61
33603602 2020
39
An Integrated Pharmacophore/Docking/3D-QSAR Approach to Screening a Large Library of Products in Search of Future Botulinum Neurotoxin A Inhibitors. 61
33322848 2020
40
Phage lysin that specifically eliminates Clostridium botulinum Group I cells. 61
33299101 2020
41
Toxemia in Human Naturally Acquired Botulism. 61
33202855 2020
42
Early recovery of botulism: one decade of experience. 61
33156710 2020
43
The Role of Therapeutic Plasma Exchange in the Treatment of Childhood Intoxication: A Single-Center Experience. 61
32701752 2020
44
Dysphagia Alone as a Unique Presentation of Wound Botulism in the Emergency Department: A Case Report. 61
33217286 2020
45
Special Delivery: Potential Mechanisms of Botulinum Neurotoxin Uptake and Trafficking within Motor Nerve Terminals. 61
33218099 2020
46
Assessment of the risk of botulism from chilled, vacuum/modified atmosphere packed fresh beef, lamb and pork held at 3 °C-8 °C. 61
32539958 2020
47
Notes from the Field: Botulism Type B After Intravenous Methamphetamine Use - New Jersey, 2020. 61
33001870 2020
48
High prevalence of Clostridium botulinum in vegetarian sausages. 61
32539985 2020
49
Adverse Events Associated With Botox as Reported in a Food and Drug Administration Database. 61
33128076 2020
50
Managing botulism outbreaks associated with poultry litter: balancing perceived animal welfare with disease prevention. 61
32948720 2020

Variations for Foodborne Botulism

Expression for Foodborne Botulism

Search GEO for disease gene expression data for Foodborne Botulism.

Pathways for Foodborne Botulism

Pathways related to Foodborne Botulism according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.4 VAMP2 VAMP1 SYT2 SYT1 SV2C SV2B
2 12.3 VAMP2 VAMP1 SYT1 SV2A SNAP25
3
Show member pathways
12.03 VAMP4 VAMP2 SYT8 SYT2 SYT1
4
Show member pathways
11.83 SV2C SV2B SV2A
5
Show member pathways
11.69 VAMP2 SYT1 SNAP25
6
Show member pathways
11.63 VAMP4 VAMP2 VAMP1 SNAP25
7
Show member pathways
11.12 VAMP2 VAMP1 SYT2 SYT1 SV2C SV2B
8
Show member pathways
10.35 VAMP2 VAMP1 SV2C SV2B SV2A
9 10.29 VAMP2 SYT1 SNAP25

GO Terms for Foodborne Botulism

Cellular components related to Foodborne Botulism according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 10.49 VAPA VAMP4 VAMP2 VAMP1 SYT8 SYT3
2 integral component of membrane GO:0016021 10.4 VAPA VAMP4 VAMP2 VAMP1 SYT8 SYT3
3 plasma membrane GO:0005886 10.37 VAPA VAMP4 VAMP2 VAMP1 SYT8 SYT3
4 synapse GO:0045202 10.03 VAMP2 VAMP1 SYT2 SYT1 SV2C SV2B
5 cell junction GO:0030054 10.02 VAPA VAMP2 VAMP1 SYT2 SYT1 SV2C
6 cytoplasmic vesicle GO:0031410 9.97 VAMP2 VAMP1 SYT8 SYT3 SYT2 SYT1
7 neuron projection GO:0043005 9.95 VAMP2 VAMP1 SYT1 SV2C SV2B SV2A
8 axon GO:0030424 9.91 SYT8 SYT2 SYT1 SNAP25
9 vesicle GO:0031982 9.86 VAPA VAMP2 SYT8 SNAP25
10 clathrin-coated vesicle membrane GO:0030665 9.78 VAMP4 VAMP2 SYT2 SYT1
11 SNARE complex GO:0031201 9.76 VAMP4 VAMP2 VAMP1 SNAP25
12 dense core granule GO:0031045 9.69 SYT8 SYT2 SYT1
13 integral component of synaptic vesicle membrane GO:0030285 9.65 VAMP4 VAMP1 SYT1 SV2C SV2A
14 neuron projection terminus GO:0044306 9.6 VAMP2 SYT1
15 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 9.58 VAMP2 SYT1
16 chromaffin granule membrane GO:0042584 9.57 SYT2 SYT1
17 synaptic vesicle GO:0008021 9.56 VAMP4 VAMP2 SYT2 SYT1 SV2C SV2B
18 clathrin-sculpted monoamine transport vesicle membrane GO:0070083 9.55 VAMP2 SYT1
19 exocytic vesicle GO:0070382 9.55 SYT8 SYT3 SYT2 SYT17 SYT1
20 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex GO:0070032 9.54 VAMP2 SNAP25
21 clathrin-sculpted glutamate transport vesicle membrane GO:0060203 9.52 VAMP2 SYT1
22 synaptic vesicle membrane GO:0030672 9.23 VAMP2 VAMP1 SYT8 SYT2 SYT1 SV2C

Biological processes related to Foodborne Botulism according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.92 SYT1 SV2C SV2B SV2A SNAP25
2 membrane organization GO:0061024 9.86 VAMP4 VAMP2 SYT2 SYT1
3 vesicle-mediated transport GO:0016192 9.86 VAMP4 VAMP2 VAMP1 SYT8 SYT3 SYT2
4 exocytosis GO:0006887 9.83 VAMP2 SYT8 SYT17 SYT16 SNAP25
5 cellular response to calcium ion GO:0071277 9.77 SYT8 SYT3 SYT2 SYT17 SYT1
6 neurotransmitter secretion GO:0007269 9.76 VAMP2 SYT2 SYT1 SNAP25
7 neurotransmitter transport GO:0006836 9.74 SV2C SV2B SV2A
8 vesicle fusion GO:0006906 9.72 VAMP2 VAMP1 SNAP25
9 glutamate secretion GO:0014047 9.71 VAMP2 SYT1 SNAP25
10 synaptic vesicle endocytosis GO:0048488 9.71 VAMP2 SYT8 SYT2 SYT1
11 synaptic vesicle exocytosis GO:0016079 9.69 VAMP2 SYT1 SNAP25
12 calcium ion-regulated exocytosis of neurotransmitter GO:0048791 9.67 SYT8 SYT2 SYT1
13 SNARE complex assembly GO:0035493 9.65 VAMP4 VAMP2 VAMP1
14 positive regulation of dendrite extension GO:1903861 9.62 SYT3 SYT2 SYT17 SYT1
15 Golgi to plasma membrane protein transport GO:0043001 9.58 VAMP4 VAMP2
16 synaptic vesicle priming GO:0016082 9.58 SV2A SNAP25
17 regulation of dopamine secretion GO:0014059 9.55 SYT8 SYT3 SYT2 SYT17 SYT1
18 regulation of calcium ion-dependent exocytosis GO:0017158 9.35 SYT8 SYT3 SYT2 SYT17 SYT1
19 calcium ion regulated exocytosis GO:0017156 9.1 VAMP2 SYT8 SYT3 SYT2 SYT17 SYT1

Molecular functions related to Foodborne Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium ion binding GO:0005509 9.88 SYT8 SYT3 SYT2 SYT17 SYT1
2 phosphatidylserine binding GO:0001786 9.72 SYT8 SYT3 SYT2 SYT17 SYT1
3 calcium-dependent protein binding GO:0048306 9.67 VAMP2 SYT8 SYT1 SNAP25
4 calcium-dependent phospholipid binding GO:0005544 9.65 SYT8 SYT3 SYT2 SYT17 SYT1
5 phospholipid binding GO:0005543 9.63 VAMP2 SYT16 SYT1
6 SNAP receptor activity GO:0005484 9.61 VAMP2 VAMP1 SNAP25
7 syntaxin-1 binding GO:0017075 9.58 VAMP2 SYT1 SNAP25
8 clathrin binding GO:0030276 9.55 SYT8 SYT3 SYT2 SYT17 SYT1
9 SNARE binding GO:0000149 9.5 VAMP2 SYT8 SYT3 SYT2 SYT17 SYT1
10 syntaxin binding GO:0019905 9.23 VAMP2 VAMP1 SYT8 SYT3 SYT2 SYT17

Sources for Foodborne Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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