MCID: FDB001
MIFTS: 56

Foodborne Botulism

Categories: Eye diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Foodborne Botulism

MalaCards integrated aliases for Foodborne Botulism:

Name: Foodborne Botulism 12 12 52 58 15
Botulism 12 74 52 58 54 42 3 43 15 17 32
Wound Botulism 52 71
Intoxication with Clostridium Botulinum Toxin 12
Food Poisoning Due to Clostridium Botulinum 12
Infection Due to Clostridium Botulinum 12
Intoxication Botulism 58
Botulism, Infantile 71
Botulism Poisoning 12
Infant Botulism 52

Characteristics:

Orphanet epidemiological data:

58
foodborne botulism
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Romania); Age of onset: All ages; Age of death: any age;
botulism
Prevalence: <1/1000000 (Europe),<1/1000000 (Worldwide),1-9/1000000 (France),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050352 DOID:11976
MeSH 43 D001906
NCIt 49 C84599
SNOMED-CT 67 49248004
ICD10 32 A05.1
MESH via Orphanet 44 D001906
ICD10 via Orphanet 33 A05.1
UMLS via Orphanet 72 C0006057 C1739094
UMLS 71 C0006057 C0238027 C1306794

Summaries for Foodborne Botulism

MedlinePlus : 42 Botulism is a rare but serious illness. The cause is a toxin (poison) made by a bacterium called Clostridium botulinum. It occurs naturally in soil. There are several kinds of botulism. Foodborne botulism comes from eating foods contaminated with the toxin. Wound botulism happens when a wound infected with the bacteria makes the toxin. It is more common in heroin users. Infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. All forms can be deadly and are medical emergencies. Symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. Treatment may include antitoxins, intensive medical care, or surgery of infected wounds. To prevent botulism: Be very careful when canning foods at home Do not let babies eat honey Get prompt medical care for infected wounds Centers for Disease Control and Prevention

MalaCards based summary : Foodborne Botulism, also known as botulism, is related to wound botulism and intestinal botulism. An important gene associated with Foodborne Botulism is SNAP25 (Synaptosome Associated Protein 25), and among its related pathways/superpathways are HIV Life Cycle and Transmission across Chemical Synapses. The drugs Immunologic Factors and Antitoxins have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and brain, and related phenotypes are ptosis and diplopia

Disease Ontology : 12 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located in neuromuscular junction resulting in descending muscle paralysis, has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F.

CDC : 3 Botulism is a rare but serious illness caused by a toxin that attacks the body's nerves.

Wikipedia : 74 Botulism is a rare and potentially fatal illness caused by a toxin produced by the bacterium Clostridium... more...

Related Diseases for Foodborne Botulism

Diseases related to Foodborne Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 wound botulism 32.2 VAPA SYT2 SV2C SV2A SNAP25 NSF
2 intestinal botulism 29.5 SV2C GPA33 FBXW2 BRD3
3 tetanus 29.5 VAMP2 STX1A SNAP25 NSF
4 infant botulism 27.3 VAPA VAMP2 VAMP1 SYT2 SYT1 SV2C
5 adult intestinal botulism 12.5
6 inhalational botulism 12.5
7 iatrogenic botulism 12.5
8 toxin-mediated infectious botulism 12.3
9 respiratory failure 10.5
10 dysphagia 10.4
11 sudden infant death syndrome 10.4
12 ptosis 10.4
13 constipation 10.4
14 diphtheria 10.4
15 spasticity 10.4
16 ataxia and polyneuropathy, adult-onset 10.3
17 ileus 10.3
18 kearns-sayre syndrome 10.3
19 poliomyelitis 10.3
20 lambert-eaton myasthenic syndrome 10.2
21 dystonia 10.2
22 miller fisher syndrome 10.2
23 gastroenteritis 10.2
24 anthrax disease 10.2
25 autoimmune disease 10.1
26 craniofacial-deafness-hand syndrome 10.1
27 ocular motor apraxia 10.1
28 cardiac arrest 10.1
29 cranial nerve palsy 10.1
30 paralytic ileus 10.1
31 autonomic dysfunction 10.1
32 hypotonia 10.1
33 myasthenia gravis 10.1
34 presynaptic congenital myasthenic syndromes 10.1 VAMP1 SYT2 SNAP25
35 bronchopneumonia 10.1
36 cerebral palsy 10.1
37 tremor 10.1
38 alcohol-related birth defect 10.1 SV2C SV2A
39 aspiration pneumonia 10.0
40 colitis 10.0
41 clostridium difficile colitis 10.0
42 spinal muscular atrophy 10.0
43 acute cystitis 10.0
44 muscular atrophy 10.0
45 benign familial infantile epilepsy 10.0 SYT2 SYT1 SNAP25
46 strabismus 10.0
47 lambert syndrome 10.0
48 variola major 10.0
49 parotitis 10.0
50 pasteurellosis 10.0

Graphical network of the top 20 diseases related to Foodborne Botulism:



Diseases related to Foodborne Botulism

Symptoms & Phenotypes for Foodborne Botulism

Human phenotypes related to Foodborne Botulism:

58 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 ptosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000508
2 diplopia 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0000651
3 dysarthria 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0001260
4 dysphagia 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0002015
5 constipation 58 31 frequent (33%) Frequent (79-30%),Very frequent (99-80%) HP:0002019
6 cranial nerve paralysis 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0006824
7 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
8 abdominal pain 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0002027
9 xerostomia 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0000217
10 diarrhea 58 31 occasional (7.5%) Occasional (29-5%),Very frequent (99-80%) HP:0002014
11 cerebral palsy 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0100021
12 diaphragmatic paralysis 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0006597
13 mydriasis 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0011499
14 muscle flaccidity 58 31 hallmark (90%) Very frequent (99-80%) HP:0010547
15 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0002017
16 respiratory insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0002093
17 respiratory insufficiency due to muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0002747
18 arrhythmia 58 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0011675
19 urinary retention 58 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0000016
20 cardiorespiratory arrest 58 31 occasional (7.5%) Occasional (29-5%) HP:0006543
21 muscle weakness 58 Very frequent (99-80%)
22 paralysis 58 Very frequent (99-80%)
23 diaphragmatic weakness 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Foodborne Botulism:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.28 GP2 HAS1 SNAP25 STX1A SV2A SV2B

Drugs & Therapeutics for Foodborne Botulism

Drugs for Foodborne Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 4
2 Antitoxins Phase 4
3 Botulinum Antitoxin Phase 4
4
Amifampridine Approved, Investigational Phase 2, Phase 3 54-96-6 5918
5
Acetylcholine Approved, Investigational Phase 3 51-84-3 187
6 Potassium Channel Blockers Phase 2, Phase 3
7 Neurotransmitter Agents Phase 3
8 Acetylcholine Release Inhibitors Phase 3
9 abobotulinumtoxinA Phase 3
10 Neuromuscular Agents Phase 3
11 Botulinum Toxins, Type A Phase 3
12 Botulinum Toxins Phase 3
13 Cholinergic Agents Phase 3
14
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
15 Antibodies Phase 2
16 Immunoglobulins Phase 2
17 Antibodies, Monoclonal Phase 1
18 Rho(D) Immune Globulin
19 gamma-Globulins
20 Immunoglobulins, Intravenous
21 incobotulinumtoxinA

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Pharmacokinetics of Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G) - (Equine) (BAT™) in Pediatric Patients With a Confirmed or Suspected Exposure to Botulinum Toxin. Completed NCT02051062 Phase 4
2 Pilot Study on the Usefulness of 3,4-diaminopyridine in the Treatment of Botulism Completed NCT01441557 Phase 2, Phase 3 3,4-diaminopyridine
3 The Efficacy and Safety of Botulinum Toxin for the Treatment of Trigeminal Neuralgia: Comparison of Two Different Treatment Methods Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
4 A 48-Week Prospective, Double-Blinded, Randomized, Cross-over Design in Multicenter Study of 250 Unit of Dysport Versus 50 Unit of Neuronox Injection For Cervical Dystonia in Thai Patients Recruiting NCT03805152 Phase 3 Neuronox(R);Dysport (R)
5 A Phase 3, Double Blind, Placebo Controlled, Randomized, Multicenter Clinical Trial to Demonstrate the Safety, Lot Consistency and Clinical Benefit of Recombinant Botulinum Vaccine A/B (rBV A/B) Withdrawn NCT01940315 Phase 3
6 Phase 2b, Two-part, Open-label, Uncontrolled Study to Evaluate Safety, Tolerability, and Immunogenicity of a Single 40-µg Dose of Recombinant Botulinum Vaccine A/B (rBV A/B) for the Production of BabyBIG® in Volunteers Previously Immunized With Pentavalent Botulinum Toxoid for Occupational Protection Completed NCT01701999 Phase 2
7 A Phase 2, Randomized, Double Blind, Placebo-Controlled, Multicenter Study to Evaluate Safety, Dosing Schedule and Antibody Kinetics of Recombinant Botulinum Vaccine A/B, rBV A/B-40, in Healthy Adults Completed NCT00764634 Phase 2
8 Tolerability and Immunogenicity of a Single 40-µg Dose of Recombinant Botulinum Vaccine A/B (rBV A/B) for the Production of BabyBIG® in Volunteers With Existing Botulinum Immunity Active, not recruiting NCT03676634 Phase 2
9 Pharmacokinetics of a Heptavalent Equine-derived Botulinum Antitoxin (NP-018) Completed NCT00360737 Phase 1
10 Botulism Antitoxin Effects on Paralysis Induced by Type A and Type B Botulinum Neurotoxins in the Extensor Digitorum Brevis Muscle Completed NCT00636519 Phase 1
11 Evaluation of the Improvement of Quality of Life of Patients Suffering From Hailey Hailey or Darier Disease After Injections of Botulism Toxin Into Large Folds. Toxin Hailey Darier Completed NCT02782702 Phase 1 Botulism Toxin Treatment
12 A Phase I, Blinded, Placebo-controlled, Dose-escalation Study of the Safety and Pharmacokinetics of XOMA 3AB Administered Intravenously in Healthy Adults Completed NCT01357213 Phase 1 XOMA 3AB
13 A Phase I, Double-Blind, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of NTM-1632 vs Placebo Administered Intravenously in Healthy Adults Completed NCT02779140 Phase 1
14 A Phase I, Double-Blind, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of NTM-1633 vs Placebo Administered Intravenously in Healthy Adults Completed NCT03603665 Phase 1
15 A Phase 1, Randomized, Double-Blind, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of a Single IM Dose of G03-52-01 vs Placebo in Adult Subjects Not yet recruiting NCT04171115 Phase 1 G03-52-01;Placebo
16 Retrospective Epidemiological Study on Patients Admitted for Botulism Poisoning in Intensive Care Units in France Completed NCT03658902
17 Study of Human Botulism Immunoglobulin in Infants With Botulism Completed NCT00004401 botulism immune globulin
18 Clinical Manifestations of Botulism Outbreak in Northern Thailand: A Case Series of Botulism Treated With Botulinum Anti-Toxin. Completed NCT00348426 Botulinum AntiToxin
19 An Outbreak of Botulism in Thailand: Clinical Manifestations and Management of Severe Respiratory Failure Completed NCT00314080 Botulinum AntiToxin
20 Botulinum Antitoxin Patient Registry for the Evaluation of Safety and Clinical Outcomes of Pediatric and Adult Patients Following BAT Treatment for Confirmed or Suspected Exposure to Botulinum Toxin. Completed NCT02055183 BAT
21 The Pilot Study of Constraint Induced Movement Therapy(CIMT) Intervention in Children With Hemiplegic Cerebral Palsy After Botulism Toxin Injection in Preschool Education Completed NCT04179682
22 Effect of Agave Syrup, Placebo, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Infants/Toddlers and Their Parents Completed NCT01721395
23 The Clinical Effect and Sonographic Findings of Kinesiotaping Combined With Therapeutic Exercise in Upper Extremity Spasticity and Function in Subacute Stroke Patients Completed NCT03024190
24 A Training Protocol for the Use of Botulinum Toxin in the Treatment of Neurological Disorders Recruiting NCT00001208
25 The Functional Outcome of Hemiplegic Upper Extremity in Patients With Subacute Stroke After Kinesiotaping Combined With Rehabilitation Not yet recruiting NCT04027985

Search NIH Clinical Center for Foodborne Botulism

Cochrane evidence based reviews: botulism

Genetic Tests for Foodborne Botulism

Anatomical Context for Foodborne Botulism

MalaCards organs/tissues related to Foodborne Botulism:

40
Testes, Colon, Brain, Spinal Cord, Eye, Skin, Breast

Publications for Foodborne Botulism

Articles related to Foodborne Botulism:

(show top 50) (show all 3208)
# Title Authors PMID Year
1
Hospital-acquired intestinal toxemia botulism in a newly diagnosed adult colon cancer patient. 61 42
31531627 2019
2
Medical treatment for botulism. 61 42
30993666 2019
3
Botulism - a rare but still present, life-threatening disease. 42 61
31181950 2019
4
Rescue of exocytosis in botulinum toxin A-poisoned chromaffin cells by expression of cleavage-resistant SNAP-25. Identification of the minimal essential C-terminal residues. 54 61
10601242 1999
5
Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds. 61 54
8243676 1993
6
Acute Neuromuscular Disorders in the Pediatric Intensive Care Unit. 61
31502491 2020
7
Botulinum Toxin Type A in Dental Medicine. 61
31533008 2019
8
Lambert-Eaton Myasthenic Syndrome, Botulism, and Immune Checkpoint Inhibitor-Related Myasthenia Gravis. 61
31794471 2019
9
Critical Analysis of Neuronal Cell and the Mouse Bioassay for Detection of Botulinum Neurotoxins. 61
31817843 2019
10
Repurposing of FDA-Approved Drugs for Treating Iatrogenic Botulism: A Paired 3D-QSAR/Docking Approach†. 61
31774239 2019
11
Bugs, Bites, and Botulism. 61
31706450 2019
12
Tables of Toxicity of Botulinum and Tetanus Neurotoxins. 61
31771110 2019
13
Sodium nitrite negatively affects reproductive ability and offspring survival in female mice. 61
31476334 2019
14
A Case Report of a Botulism Outbreak in Beef Cattle Due to the Contamination of Wheat by a Roaming Cat Carcass: From the Suspicion to the Management of the Outbreak. 61
31775272 2019
15
The role of the single interchains disulfide bond in tetanus and botulinum neurotoxins and the development of antitetanus and antibotulism drugs. 61
31050145 2019
16
Notes from the Field: Botulism Type E After Consumption of Salt-Cured Fish - New Jersey, 2018. 61
31697653 2019
17
Botulism in Wild Birds and Changes in Environmental Habitat: A Relationship to be Considered. 61
31779284 2019
18
Outbreak of Foodborne Botulism Associated with Improperly Earthenware Cheese (Koupé): A Case Report. 61
31850271 2019
19
Safety and Pharmacokinetics of a Four Monoclonal Antibody Combination Against Botulinum C and D Neurotoxins. 61
31591130 2019
20
Evaluation of the occurrence of sporulating and nonsporulating pathogenic bacteria in manure and in digestate of five agricultural biogas plants. 61
31568706 2019
21
Avian botulism - a recurring paralytic disease of wild UK waterbirds. 61
31488639 2019
22
Needle in a Haystack: A Missed Case of Wound Botulism. 61
30951679 2019
23
Botulism in pregnancy - a clinical approach to diagnosis and management. 61
29577785 2019
24
Comparative functional analysis of mice after local injection with botulinum neurotoxin A1, A2, A6, and B1 by catwalk analysis. 61
31181297 2019
25
Vaccine Production to Protect Animals Against Pathogenic Clostridia. 61
31514424 2019
26
Antibodies and Vaccines against Botulinum Toxins: Available Measures and Novel Approaches. 61
31547338 2019
27
Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice. 61
31394847 2019
28
Ethical rationales for past and present military medical practices. 61
30530790 2019
29
Lead exposure in common shelduck (Tadorna tadorna): Tracking the success of the Pb shot ban for hunting in Spanish wetlands. 61
31063795 2019
30
Revisiting the Evolution and Taxonomy of Clostridia, a Phylogenomic Update. 61
31076745 2019
31
Development and Characterization of Monoclonal Antibodies to Botulinum Neurotoxin Type E. 61
31337022 2019
32
Rapid Detection of Botulinum Neurotoxins-A Review. 61
31319550 2019
33
Proposed BoNT/A and /B Peptide Substrates Cannot Detect Multiple Subtypes in the Endopep-MS Assay. 61
31287544 2019
34
Neuroterrorism Preparedness for the Neurohospitalist. 61
31244972 2019
35
Development and evaluation of candidate subunit vaccine and novel antitoxin against botulinum neurotoxin serotype E. 61
31210561 2019
36
What links the mascarpone and nacho cheese sauce outbreaks of botulism. 61
31342063 2019
37
Foodborne Botulism Outbreak Associated with Commercial Nacho Cheese Sauce from a Gas Station Market. 61
31247064 2019
38
Safety and Clinical Outcomes of an Equine-Derived Heptavalent Botulinum Antitoxin Treatment for Confirmed or Suspected Botulism in the United States. 61
31209461 2019
39
Botulinum and Tetanus Neurotoxins. 61
30388027 2019
40
Pharmacokinetics of Human Recombinant Anti-Botulinum Toxin Antibodies in Rats. 61
31212950 2019
41
Upper extremity conversion disorder in children. 61
30685281 2019
42
Miller Fisher syndrome mimicking botulism: Clinical and pathophysiological discussion of a case. 61
31047688 2019
43
Molecular Characterization of Clostridium botulinum Harboring the bont/B7 Gene. 61
30932710 2019
44
Autonomic dysfunction in the neurological intensive care unit. 61
30022321 2019
45
Cosmetic Injection of Botulinum Toxin Unmasking Subclinical Myasthenia Gravis: A Case Report and Literature Review. 61
31572161 2019
46
The First Case of Botulism in a Donkey. 61
31096593 2019
47
Virulence Plasmids of the Pathogenic Clostridia. 61
31111816 2019
48
Immunogenicity evaluation of rBoNT/E nanovaccine after mucosal administration. 61
31168338 2019
49
Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology. 61
30940836 2019
50
Is botulism type C transmissible to human by consumption of contaminated poultry meat? Analysis of a suspect outbreak in French Guyana. 61
30763675 2019

Variations for Foodborne Botulism

Expression for Foodborne Botulism

Search GEO for disease gene expression data for Foodborne Botulism.

Pathways for Foodborne Botulism

Pathways related to Foodborne Botulism according to GeneCards Suite gene sharing:

(show all 14)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.5 VAMP2 VAMP1 SYT2 SYT1 SV2C SV2B
2
Show member pathways
12.79 VAMP2 SYT2 SYT1 STX1A SNAP25 NSF
3
Show member pathways
12.69 VAPA VAMP2 VAMP1 STX1A SNAP25
4 12.33 VAMP2 VAMP1 SYT1 SV2A STX1A SNAP25
5
Show member pathways
12.22 VAMP2 STX1A SNAP25 NSF
6
Show member pathways
11.96 VAMP2 SYT1 STX1A SNAP25
7
Show member pathways
11.91 SV2C SV2B SV2A
8
Show member pathways
11.83 VAMP2 SYT1 STX1A SNAP25 NSF
9
Show member pathways
11.81 SYT2 SYT1 STX1A
10
Show member pathways
11.68 VAMP2 VAMP1 STX1A SNAP25
11
Show member pathways
11.17 VAMP2 SNAP25 NSF
12
Show member pathways
11.17 VAMP2 VAMP1 SYT2 SYT1 SV2C SV2B
13 10.41 VAMP2 SYT1 STX1A SNAP25
14
Show member pathways
10.35 VAMP2 VAMP1 SV2C SV2B SV2A

GO Terms for Foodborne Botulism

Cellular components related to Foodborne Botulism according to GeneCards Suite gene sharing:

(show all 27)
# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.39 VAPA VAMP2 SYT2 SYT1 SV2C SV2B
2 integral component of plasma membrane GO:0005887 10.11 VAMP2 VAMP1 SV2C SV2B SV2A STX1A
3 cytoplasmic vesicle GO:0031410 10.03 VAMP2 VAMP1 SYT2 SYT1 SV2C SV2B
4 synapse GO:0045202 10.02 VAMP2 VAMP1 SYT2 SYT1 SV2C SV2B
5 cell junction GO:0030054 9.96 VAPA VAMP2 VAMP1 SYT2 SYT1 SV2C
6 axon GO:0030424 9.93 SYT2 SYT1 STX1A SNAP25
7 glutamatergic synapse GO:0098978 9.93 VAMP1 SYT1 SV2A STX1A SNAP25
8 neuron projection GO:0043005 9.92 VAMP2 VAMP1 SYT1 SV2C SV2B SV2A
9 secretory granule GO:0030141 9.79 VAMP2 SYT1 STX1A
10 voltage-gated potassium channel complex GO:0008076 9.77 VAMP2 STX1A SNAP25
11 presynaptic membrane GO:0042734 9.77 SYT1 STX1A SNAP25
12 clathrin-coated vesicle membrane GO:0030665 9.74 VAMP2 SYT2 SYT1
13 SNARE complex GO:0031201 9.72 VAMP2 STX1A SNAP25
14 exocytic vesicle GO:0070382 9.63 SYT2 SYT1
15 neuron projection terminus GO:0044306 9.62 VAMP2 SYT1
16 dense core granule GO:0031045 9.62 SYT2 SYT1
17 intracellular organelle GO:0043229 9.61 SYT1 STX1A
18 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 9.58 VAMP2 SYT1
19 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex GO:0070032 9.58 VAMP2 STX1A SNAP25
20 chromaffin granule membrane GO:0042584 9.56 SYT2 SYT1
21 synaptic vesicle GO:0008021 9.56 VAMP2 SYT2 SYT1 SV2C SV2B SV2A
22 integral component of synaptic vesicle membrane GO:0030285 9.55 VAMP1 SYT1 SV2C SV2A STX1A
23 clathrin-sculpted monoamine transport vesicle membrane GO:0070083 9.52 VAMP2 SYT1
24 synaptobrevin 2-SNAP-25-syntaxin-1a complex GO:0070044 9.49 VAMP2 STX1A
25 clathrin-sculpted glutamate transport vesicle membrane GO:0060203 9.48 VAMP2 SYT1
26 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex GO:0070033 9.46 VAMP2 STX1A
27 synaptic vesicle membrane GO:0030672 9.23 VAMP2 VAMP1 SYT2 SYT1 SV2C SV2B

Biological processes related to Foodborne Botulism according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 vesicle-mediated transport GO:0016192 9.88 VAMP2 VAMP1 SYT2 SYT1 STX1A NSF
2 chemical synaptic transmission GO:0007268 9.85 SYT1 SV2C SV2B SV2A SNAP25
3 exocytosis GO:0006887 9.78 VAMP2 STX1A SNAP25 NSF
4 membrane organization GO:0061024 9.77 VAMP2 SYT2 SYT1
5 synaptic vesicle endocytosis GO:0048488 9.67 SYT2 SYT1 STX1A
6 neurotransmitter transport GO:0006836 9.67 SV2C SV2B SV2A STX1A
7 regulation of exocytosis GO:0017157 9.62 VAMP2 SYT1 STX1A NSF
8 synaptic vesicle priming GO:0016082 9.61 VAMP1 SV2A SNAP25
9 positive regulation of dendrite extension GO:1903861 9.58 SYT2 SYT1
10 vesicle docking GO:0048278 9.58 SYT1 STX1A
11 regulation of calcium ion-dependent exocytosis GO:0017158 9.57 SYT2 SYT1
12 positive regulation of calcium ion-dependent exocytosis GO:0045956 9.56 SYT1 STX1A
13 calcium ion regulated exocytosis GO:0017156 9.56 VAMP2 SYT2 SYT1 STX1A
14 calcium ion-regulated exocytosis of neurotransmitter GO:0048791 9.55 SYT2 SYT1
15 synaptic vesicle fusion to presynaptic active zone membrane GO:0031629 9.54 STX1A SNAP25
16 synaptic vesicle docking GO:0016081 9.52 STX1A SNAP25
17 SNARE complex assembly GO:0035493 9.51 VAMP1 STX1A
18 glutamate secretion GO:0014047 9.46 VAMP2 SYT1 STX1A SNAP25
19 neurotransmitter secretion GO:0007269 9.35 VAMP2 SYT2 SYT1 STX1A SNAP25
20 synaptic vesicle exocytosis GO:0016079 9.02 VAMP2 SYT2 SYT1 STX1A SNAP25

Molecular functions related to Foodborne Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-dependent protein binding GO:0048306 9.56 VAMP2 SYT1 STX1A SNAP25
2 syntaxin-1 binding GO:0017075 9.46 VAMP2 SYT1 SNAP25 NSF
3 SNARE binding GO:0000149 9.35 VAMP2 SYT2 SYT1 STX1A NSF
4 syntaxin binding GO:0019905 9.02 VAMP2 SYT2 SYT1 SNAP25 NSF

Sources for Foodborne Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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