MCID: FDB001
MIFTS: 55

Foodborne Botulism

Categories: Eye diseases, Infectious diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Foodborne Botulism

MalaCards integrated aliases for Foodborne Botulism:

Name: Foodborne Botulism 12 12 52 58 15
Botulism 12 74 52 58 54 42 3 43 15 17 32
Wound Botulism 52 71
Intoxication with Clostridium Botulinum Toxin 12
Food Poisoning Due to Clostridium Botulinum 12
Infection Due to Clostridium Botulinum 12
Intoxication Botulism 58
Botulism, Infantile 71
Botulism Poisoning 12
Infant Botulism 52

Characteristics:

Orphanet epidemiological data:

58
foodborne botulism
Prevalence: 1-9/1000000 (Europe),1-9/1000000 (Romania); Age of onset: All ages; Age of death: any age;
botulism
Prevalence: <1/1000000 (Europe),<1/1000000 (Worldwide),1-9/1000000 (France),1-9/1000000 (United States); Age of onset: All ages; Age of death: any age;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare eye diseases
Rare infectious diseases


External Ids:

Disease Ontology 12 DOID:0050352 DOID:11976
MeSH 43 D001906
NCIt 49 C84599
SNOMED-CT 67 414531002
ICD10 32 A05.1
MESH via Orphanet 44 D001906
ICD10 via Orphanet 33 A05.1
UMLS via Orphanet 72 C0006057 C1739094
UMLS 71 C0006057 C0238027 C1306794

Summaries for Foodborne Botulism

MedlinePlus : 42 Botulism is a rare but serious illness. The cause is a toxin (poison) made by a bacterium called Clostridium botulinum. It occurs naturally in soil. There are several kinds of botulism. Foodborne botulism comes from eating foods contaminated with the toxin. Wound botulism happens when a wound infected with the bacteria makes the toxin. It is more common in heroin users. Infant botulism happens when a baby consumes the spores of the bacteria from soil or honey. All forms can be deadly and are medical emergencies. Symptoms include double or blurred vision, drooping eyelids, slurred speech, difficulty swallowing, dry mouth, and muscle weakness. Treatment may include antitoxins, intensive medical care, or surgery of infected wounds. To prevent botulism: Be very careful when canning foods at home Do not let babies eat honey Get prompt medical care for infected wounds Centers for Disease Control and Prevention

MalaCards based summary : Foodborne Botulism, also known as botulism, is related to wound botulism and tetanus. An important gene associated with Foodborne Botulism is SNAP25 (Synaptosome Associated Protein 25), and among its related pathways/superpathways are HIV Life Cycle and Transmission across Chemical Synapses. The drugs Antitoxins and Botulinum Antitoxin have been mentioned in the context of this disorder. Affiliated tissues include testes, colon and brain, and related phenotypes are fatigue and cranial nerve paralysis

Disease Ontology : 12 A primary bacterial infectious disease that involves intoxication caused by botulinum neurotoxins (BoNTA, B, E and F) located in neuromuscular junction resulting in descending muscle paralysis, has material basis in Clostridium botulinum A, has material basis in Clostridium botulinum B, has material basis in Clostridium botulinum E and has material basis in Clostridium botulinum F.

CDC : 3 Botulism is a rare but serious illness caused by a toxin that attacks the body's nerves.

Wikipedia : 74 Botulism is a rare and potentially fatal illness caused by a toxin produced by the bacterium Clostridium... more...

Related Diseases for Foodborne Botulism

Diseases related to Foodborne Botulism via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 175)
# Related Disease Score Top Affiliating Genes
1 wound botulism 32.9 VAPA VAMP2 SV2A SNAP25 NSF GPA33
2 tetanus 30.3 VAMP2 SNAP25 NSF
3 intestinal botulism 29.4 SYT2 SV2C SV2A NSF GPA33 BRD3
4 infant botulism 28.0 VAPA VAMP4 VAMP2 VAMP1 SYT2 SV2C
5 adult intestinal botulism 12.6
6 inhalational botulism 12.5
7 iatrogenic botulism 12.5
8 toxin-mediated infectious botulism 12.4
9 respiratory failure 10.5
10 dysphagia 10.4
11 sudden infant death syndrome 10.4
12 ptosis 10.4
13 constipation 10.4
14 diphtheria 10.4
15 spasticity 10.4
16 ataxia and polyneuropathy, adult-onset 10.3
17 ileus 10.3
18 kearns-sayre syndrome 10.3
19 poliomyelitis 10.3
20 lambert-eaton myasthenic syndrome 10.2
21 dystonia 10.2
22 miller fisher syndrome 10.2
23 gastroenteritis 10.2
24 anthrax disease 10.2
25 spinal muscular atrophy 10.1
26 muscular atrophy 10.1
27 autoimmune disease 10.1
28 craniofacial-deafness-hand syndrome 10.1
29 ocular motor apraxia 10.1
30 cardiac arrest 10.1
31 cranial nerve palsy 10.1
32 paralytic ileus 10.1
33 autonomic dysfunction 10.1
34 hypotonia 10.1
35 myasthenia gravis 10.1
36 presynaptic congenital myasthenic syndromes 10.1 VAMP1 SYT2 SNAP25
37 parotitis 10.1
38 bronchopneumonia 10.1
39 cerebral palsy 10.1
40 tremor 10.1
41 benign familial infantile epilepsy 10.1 SYT2 SYT1 SNAP25
42 aspiration pneumonia 10.1
43 clostridium difficile colitis 10.1
44 acute cystitis 10.1
45 strabismus 10.0
46 lambert syndrome 10.0
47 variola major 10.0
48 pasteurellosis 10.0
49 pertussis 10.0
50 lyme disease 10.0

Graphical network of the top 20 diseases related to Foodborne Botulism:



Diseases related to Foodborne Botulism

Symptoms & Phenotypes for Foodborne Botulism

Human phenotypes related to Foodborne Botulism:

58 31 (show all 23)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 fatigue 58 31 hallmark (90%) Very frequent (99-80%) HP:0012378
2 cranial nerve paralysis 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0006824
3 dysphagia 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0002015
4 xerostomia 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0000217
5 abdominal pain 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0002027
6 ptosis 58 31 hallmark (90%) Very frequent (99-80%) HP:0000508
7 dysarthria 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0001260
8 constipation 58 31 frequent (33%) Frequent (79-30%),Very frequent (99-80%) HP:0002019
9 cerebral palsy 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0100021
10 diaphragmatic paralysis 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0006597
11 diplopia 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0000651
12 diarrhea 58 31 occasional (7.5%) Occasional (29-5%),Very frequent (99-80%) HP:0002014
13 muscle flaccidity 58 31 hallmark (90%) Very frequent (99-80%) HP:0010547
14 mydriasis 58 31 hallmark (90%) Very frequent (99-80%),Very frequent (99-80%) HP:0011499
15 respiratory insufficiency due to muscle weakness 58 31 frequent (33%) Frequent (79-30%) HP:0002747
16 arrhythmia 58 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0011675
17 nausea and vomiting 58 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0002017
18 respiratory insufficiency 58 31 frequent (33%) Frequent (79-30%) HP:0002093
19 urinary retention 58 31 frequent (33%) Frequent (79-30%),Frequent (79-30%) HP:0000016
20 cardiorespiratory arrest 58 31 occasional (7.5%) Occasional (29-5%) HP:0006543
21 muscle weakness 58 Very frequent (99-80%)
22 paralysis 58 Very frequent (99-80%)
23 diaphragmatic weakness 58 Occasional (29-5%)

MGI Mouse Phenotypes related to Foodborne Botulism:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 normal MP:0002873 9.28 FAM126A GP2 HAS1 SNAP25 SV2A SV2B

Drugs & Therapeutics for Foodborne Botulism

Drugs for Foodborne Botulism (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antitoxins Phase 4
2 Botulinum Antitoxin Phase 4
3
Amifampridine Approved, Investigational Phase 2, Phase 3 54-96-6 5918
4
Acetylcholine Approved, Investigational Phase 3 51-84-3 187
5 Potassium Channel Blockers Phase 2, Phase 3
6 abobotulinumtoxinA Phase 3
7 Cholinergic Agents Phase 3
8 Neurotransmitter Agents Phase 3
9 Botulinum Toxins Phase 3
10 Botulinum Toxins, Type A Phase 3
11
Aluminum hydroxide Approved, Investigational Phase 2 21645-51-2
12 Antibodies Phase 2
13 Immunologic Factors Phase 2
14 Immunoglobulins Phase 2
15 Antibodies, Monoclonal Phase 1
16 Immunoglobulins, Intravenous
17 Rho(D) Immune Globulin
18 gamma-Globulins
19 incobotulinumtoxinA

Interventional clinical trials:

(show all 25)
# Name Status NCT ID Phase Drugs
1 Pharmacokinetics of Botulism Antitoxin Heptavalent (A, B, C, D, E, F, G) - (Equine) (BAT™) in Pediatric Patients With a Confirmed or Suspected Exposure to Botulinum Toxin. Completed NCT02051062 Phase 4
2 Pilot Study on the Usefulness of 3,4-diaminopyridine in the Treatment of Botulism Completed NCT01441557 Phase 2, Phase 3 3,4-diaminopyridine
3 The Efficacy and Safety of Botulinum Toxin for the Treatment of Trigeminal Neuralgia: Comparison of Two Different Treatment Methods Recruiting NCT03331913 Phase 3 Botulinum Toxin type A (intradermal / submucosal injection at pain area);Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
4 A 48-Week Prospective, Double-Blinded, Randomized, Cross-over Design in Multicenter Study of 250 Unit of Dysport Versus 50 Unit of Neuronox Injection For Cervical Dystonia in Thai Patients Enrolling by invitation NCT03805152 Phase 3 Neuronox(R);Dysport (R)
5 A Phase 3, Double Blind, Placebo Controlled, Randomized, Multicenter Clinical Trial to Demonstrate the Safety, Lot Consistency and Clinical Benefit of Recombinant Botulinum Vaccine A/B (rBV A/B) Withdrawn NCT01940315 Phase 3
6 Phase 2b, Two-part, Open-label, Uncontrolled Study to Evaluate Safety, Tolerability, and Immunogenicity of a Single 40-µg Dose of Recombinant Botulinum Vaccine A/B (rBV A/B) for the Production of BabyBIG® in Volunteers Previously Immunized With Pentavalent Botulinum Toxoid for Occupational Protection Completed NCT01701999 Phase 2
7 A Phase 2, Randomized, Double Blind, Placebo-Controlled, Multicenter Study to Evaluate Safety, Dosing Schedule and Antibody Kinetics of Recombinant Botulinum Vaccine A/B, rBV A/B-40, in Healthy Adults Completed NCT00764634 Phase 2
8 Tolerability and Immunogenicity of a Single 40-µg Dose of Recombinant Botulinum Vaccine A/B (rBV A/B) for the Production of BabyBIG® in Volunteers With Existing Botulinum Immunity Active, not recruiting NCT03676634 Phase 2
9 Pharmacokinetics of a Heptavalent Equine-derived Botulinum Antitoxin (NP-018) Completed NCT00360737 Phase 1
10 Botulism Antitoxin Effects on Paralysis Induced by Type A and Type B Botulinum Neurotoxins in the Extensor Digitorum Brevis Muscle Completed NCT00636519 Phase 1
11 Evaluation of the Improvement of Quality of Life of Patients Suffering From Hailey Hailey or Darier Disease After Injections of Botulism Toxin Into Large Folds. Toxin Hailey Darier Completed NCT02782702 Phase 1 Botulism Toxin Treatment
12 A Phase I, Blinded, Placebo-controlled, Dose-escalation Study of the Safety and Pharmacokinetics of XOMA 3AB Administered Intravenously in Healthy Adults Completed NCT01357213 Phase 1 XOMA 3AB
13 A Phase I, Double-Blind, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of NTM-1632 vs Placebo Administered Intravenously in Healthy Adults Completed NCT02779140 Phase 1
14 A Phase I, Double-Blind, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of NTM-1633 vs Placebo Administered Intravenously in Healthy Adults Completed NCT03603665 Phase 1
15 A Phase 1, Randomized, Double-Blind, Dose Escalation Study to Evaluate the Safety and Pharmacokinetics of a Single IM Dose of G03-52-01 vs Placebo in Adult Subjects Not yet recruiting NCT04171115 Phase 1 G03-52-01;Placebo
16 Retrospective Epidemiological Study on Patients Admitted for Botulism Poisoning in Intensive Care Units in France Completed NCT03658902
17 Study of Human Botulism Immunoglobulin in Infants With Botulism Completed NCT00004401 botulism immune globulin
18 Clinical Manifestations of Botulism Outbreak in Northern Thailand: A Case Series of Botulism Treated With Botulinum Anti-Toxin. Completed NCT00348426 Botulinum AntiToxin
19 An Outbreak of Botulism in Thailand: Clinical Manifestations and Management of Severe Respiratory Failure Completed NCT00314080 Botulinum AntiToxin
20 Botulinum Antitoxin Patient Registry for the Evaluation of Safety and Clinical Outcomes of Pediatric and Adult Patients Following BAT Treatment for Confirmed or Suspected Exposure to Botulinum Toxin. Completed NCT02055183 BAT
21 The Pilot Study of Constraint Induced Movement Therapy(CIMT) Intervention in Children With Hemiplegic Cerebral Palsy After Botulism Toxin Injection in Preschool Education Completed NCT04179682
22 Effect of Agave Syrup, Placebo, and No Treatment on Nocturnal Cough and Sleep Quality for Coughing Infants/Toddlers and Their Parents Completed NCT01721395
23 The Clinical Effect and Sonographic Findings of Kinesiotaping Combined With Therapeutic Exercise in Upper Extremity Spasticity and Function in Subacute Stroke Patients Completed NCT03024190
24 Botulinum Toxin for the Treatment of Neurological Disorders Recruiting NCT00001208
25 The Functional Outcome of Hemiplegic Upper Extremity in Patients With Subacute Stroke After Kinesiotaping Combined With Rehabilitation Recruiting NCT04027985

Search NIH Clinical Center for Foodborne Botulism

Cochrane evidence based reviews: botulism

Genetic Tests for Foodborne Botulism

Anatomical Context for Foodborne Botulism

MalaCards organs/tissues related to Foodborne Botulism:

40
Testes, Colon, Brain, Spinal Cord, Eye, Skin, Breast

Publications for Foodborne Botulism

Articles related to Foodborne Botulism:

(show top 50) (show all 3252)
# Title Authors PMID Year
1
The First Reported Case of Infant Botulism in Korea: Treatable Infantile Neuromuscular Disease. 42 61
32281313 2020
2
Lambert-Eaton Myasthenic Syndrome, Botulism, and Immune Checkpoint Inhibitor-Related Myasthenia Gravis. 61 42
31794471 2019
3
Cost savings associated with timely treatment of botulism with botulism antitoxin heptavalent product. 42 61
31697731 2019
4
Rescue of exocytosis in botulinum toxin A-poisoned chromaffin cells by expression of cleavage-resistant SNAP-25. Identification of the minimal essential C-terminal residues. 54 61
10601242 1999
5
Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds. 54 61
8243676 1993
6
Assessment of the risk of botulism from chilled, vacuum/modified atmosphere packed fresh beef, lamb and pork held at 3 °C-8 °C. 61
32539958 2020
7
High prevalence of Clostridium botulinum in vegetarian sausages. 61
32539985 2020
8
In response to "Botulism in pregnancy - a clinical approach to diagnosis and management" published on 25 March issue. 61
30453798 2020
9
Botulinum toxin in low urinary tract disorders - over 30 years of practice (Review). 61
32509003 2020
10
A Quantum Dot Nanobiosensor for Rapid Detection of Botulinum Neurotoxin Serotype E. 61
32527082 2020
11
Botulinum Endopeptidase: SAXS Experiments and MD Simulations Reveal Extended Solution Structures That Account for Its Biochemical Properties. 61
32543194 2020
12
Towards a better understanding of the benefits and risks of country food consumption using the case of walruses in Nunavik (Northern Quebec, Canada). 61
32143094 2020
13
Case reports on dangerous infectious diseases: a review of patient consent. 61
29959178 2020
14
The dilemma of diagnosing wound botulism in an infant: A rare case of paralysis with topical application of honey. 61
32220630 2020
15
[Clinical analysis and laboratory diagnosis of three cases with infantile botulism caused by Clostridium botulinum type B]. 61
32521963 2020
16
Recombinant vaccine against botulism in buffaloes: Evaluation of the humoral immune response over 12 months. 61
32247696 2020
17
Pan-Genomic Analysis of Clostridium botulinum Group II (Non-Proteolytic C. botulinum) Associated with Foodborne Botulism and Isolated from the Environment. 61
32397147 2020
18
Human Botulism in France, 1875-2016. 61
32455538 2020
19
Two Cases of Infant Botulism Presenting with Altered Mental Status. 61
32490395 2020
20
Massage Therapy for Dystonia: a Case Report. 61
32523643 2020
21
Reevaluating the Risk of Smallpox Reemergence. 61
32373931 2020
22
Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B. 61
32392791 2020
23
Safety and Clinical Outcomes of an Equine-derived Heptavalent Botulinum Antitoxin Treatment for Confirmed or Suspected Botulism in the United States. 61
31209461 2020
24
Foodborne Botulism Outbreak Associated With Commercial Nacho Cheese Sauce From a Gas Station Market. 61
31247064 2020
25
Neuronal selectivity of botulinum neurotoxins. 61
32094099 2020
26
Novel Native and Engineered Botulinum Neurotoxins. 61
32274579 2020
27
Translocation domain of botulinum neurotoxin A subtype 2 potently induces entry into neuronal cells. 61
32301520 2020
28
Botulinum Neurotoxins: Mechanism of Action. 61
32277300 2020
29
What Links the Mascarpone and Nacho Cheese Sauce Outbreaks of Botulism. 61
31342063 2020
30
Infant botulism in Singapore. 61
32488271 2020
31
The Medical Treatment of Botulism. 61
32079791 2020
32
Protective efficacy of recombinant bacterin vaccine against botulism in cattle. 61
32037222 2020
33
Proposed BoNT/A and /B Peptide Substrates Cannot Detect Multiple Subtypes in the Endopep-MS Assay. 61
31287544 2020
34
Immunological characterisation and immunoprotective efficacy of functional domain antigens of botulinum neurotoxin serotype A. 61
32113807 2020
35
Botulism in the Pediatric Intensive Care Units in the United States: Interrogating a National Database. 61
31984151 2020
36
Potency and stability of a trivalent, catalytically inactive vaccine against botulinum neurotoxin serotypes C, E and F (triCEF). 61
32032587 2020
37
Metatranscriptomics reveals that the death of a Mongolian wild ass was caused by Clostridium botulinum in Inner Mongolia, China. 61
32065061 2020
38
Wound botulism presenting as dysphagia to an ENT ward. 61
32051157 2020
39
[Botulism: A case report and literature review]. 61
32061395 2020
40
Neuromuscular Junction Disorders and Floppy Infant Syndrome: A Comprehensive Review. 61
32071826 2020
41
Miller Fisher syndrome with bilateral vocal cord paralysis: a case report. 61
32070436 2020
42
Pharyngeal-Cervical-Brachial variant of Guillian-Barre Syndrome in Children. 61
32206455 2020
43
Newer Immunotherapies for the Treatment of Acute Neuromuscular Disease in the Critical Care Unit. 61
32052202 2020
44
Repurposing of FDA-Approved Drugs for Treating Iatrogenic Botulism: A Paired 3D-QSAR/Docking Approach†. 61
31774239 2020
45
Acute Neuromuscular Disorders in the Pediatric Intensive Care Unit. 61
31502491 2020
46
An Overlapping Case of Miller Fisher Syndrome and the Pharyngeal-Cervical-Brachial Variant of Guillain-Barré Syndrome. 61
32133309 2020
47
Adult Intestinal Toxemia Botulism. 61
31991691 2020
48
Botulism disguised as parotitis. 61
32509528 2020
49
Symptomatic treatment of botulism with a clinically approved small molecule. 61
31996484 2020
50
First record of mass wild waterfowl mortality due to Clostridium botulinum in Brazilian semiarid. 61
32321011 2020

Variations for Foodborne Botulism

Expression for Foodborne Botulism

Search GEO for disease gene expression data for Foodborne Botulism.

Pathways for Foodborne Botulism

Pathways related to Foodborne Botulism according to GeneCards Suite gene sharing:

(show all 12)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.46 VAMP2 VAMP1 SYT2 SYT1 SV2C SV2B
2
Show member pathways
12.73 VAMP2 SYT2 SYT1 SNAP25 NSF
3 12.27 VAMP2 VAMP1 SYT1 SV2A SNAP25 NSF
4
Show member pathways
12.18 VAMP4 VAMP2 SNAP25 NSF
5
Show member pathways
12.11 VAMP4 VAMP2 SYT2 SYT1
6
Show member pathways
11.88 SV2C SV2B SV2A
7
Show member pathways
11.78 VAMP2 SYT1 SNAP25 NSF
8
Show member pathways
11.63 VAMP4 VAMP2 VAMP1 SNAP25
9
Show member pathways
11.17 VAMP2 SNAP25 NSF
10
Show member pathways
11.12 VAMP2 VAMP1 SYT2 SYT1 SV2C SV2B
11
Show member pathways
10.35 VAMP2 VAMP1 SV2C SV2B SV2A
12 10.29 VAMP2 SYT1 SNAP25

GO Terms for Foodborne Botulism

Cellular components related to Foodborne Botulism according to GeneCards Suite gene sharing:

(show all 19)
# Name GO ID Score Top Affiliating Genes
1 plasma membrane GO:0005886 10.33 VAPA VAMP4 VAMP2 VAMP1 SYT2 SYT1
2 cytoplasmic vesicle GO:0031410 10.02 VAMP2 VAMP1 SYT2 SYT1 SV2C SV2B
3 synapse GO:0045202 9.97 VAMP2 VAMP1 SYT2 SYT1 SV2C SV2B
4 cell junction GO:0030054 9.97 VAPA VAMP2 VAMP1 SYT2 SYT1 SV2C
5 glutamatergic synapse GO:0098978 9.88 VAMP1 SYT1 SV2A SNAP25
6 neuron projection GO:0043005 9.86 VAMP2 VAMP1 SYT1 SV2C SV2B SV2A
7 clathrin-coated vesicle membrane GO:0030665 9.73 VAMP4 VAMP2 SYT2 SYT1
8 SNARE complex GO:0031201 9.71 VAMP4 VAMP2 VAMP1 SNAP25
9 exocytic vesicle GO:0070382 9.58 SYT2 SYT1
10 neuron projection terminus GO:0044306 9.57 VAMP2 SYT1
11 dense core granule GO:0031045 9.56 SYT2 SYT1
12 clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane GO:0061202 9.55 VAMP2 SYT1
13 integral component of synaptic vesicle membrane GO:0030285 9.55 VAMP4 VAMP1 SYT1 SV2C SV2A
14 chromaffin granule membrane GO:0042584 9.54 SYT2 SYT1
15 clathrin-sculpted monoamine transport vesicle membrane GO:0070083 9.52 VAMP2 SYT1
16 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex GO:0070032 9.51 VAMP2 SNAP25
17 synaptic vesicle membrane GO:0030672 9.5 VAMP2 VAMP1 SYT2 SYT1 SV2C SV2B
18 clathrin-sculpted glutamate transport vesicle membrane GO:0060203 9.49 VAMP2 SYT1
19 synaptic vesicle GO:0008021 9.23 VAMP4 VAMP2 SYT2 SYT1 SV2C SV2B

Biological processes related to Foodborne Botulism according to GeneCards Suite gene sharing:

(show all 18)
# Name GO ID Score Top Affiliating Genes
1 membrane organization GO:0061024 9.8 VAMP4 VAMP2 SYT2 SYT1
2 chemical synaptic transmission GO:0007268 9.77 SYT1 SV2C SV2B SV2A SNAP25
3 exocytosis GO:0006887 9.74 VAMP2 SNAP25 NSF
4 neurotransmitter transport GO:0006836 9.71 SV2C SV2B SV2A
5 synaptic vesicle endocytosis GO:0048488 9.7 VAMP2 SYT2 SYT1
6 vesicle fusion GO:0006906 9.69 VAMP2 VAMP1 SNAP25
7 regulation of exocytosis GO:0017157 9.65 VAMP2 SYT1 NSF
8 Golgi to plasma membrane protein transport GO:0043001 9.63 VAMP4 VAMP2 NSF
9 calcium ion regulated exocytosis GO:0017156 9.61 VAMP2 SYT2 SYT1
10 positive regulation of dendrite extension GO:1903861 9.58 SYT2 SYT1
11 glutamate secretion GO:0014047 9.58 VAMP2 SYT1 SNAP25
12 calcium ion-regulated exocytosis of neurotransmitter GO:0048791 9.56 SYT2 SYT1
13 regulation of calcium ion-dependent exocytosis GO:0017158 9.55 SYT2 SYT1
14 synaptic vesicle priming GO:0016082 9.5 VAMP1 SV2A SNAP25
15 neurotransmitter secretion GO:0007269 9.46 VAMP2 SYT2 SYT1 SNAP25
16 SNARE complex assembly GO:0035493 9.43 VAMP4 VAMP2 VAMP1
17 vesicle-mediated transport GO:0016192 9.43 VAMP4 VAMP2 VAMP1 SYT2 SYT1 NSF
18 synaptic vesicle exocytosis GO:0016079 8.92 VAMP2 SYT2 SYT1 SNAP25

Molecular functions related to Foodborne Botulism according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 calcium-dependent protein binding GO:0048306 9.5 VAMP2 SYT1 SNAP25
2 syntaxin-1 binding GO:0017075 9.46 VAMP2 SYT1 SNAP25 NSF
3 SNAP receptor activity GO:0005484 9.43 VAMP2 VAMP1 SNAP25
4 SNARE binding GO:0000149 9.35 VAMP2 SYT2 SYT1 SNAP25 NSF
5 syntaxin binding GO:0019905 9.1 VAMP2 VAMP1 SYT2 SYT1 SNAP25 NSF

Sources for Foodborne Botulism

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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