MCID: FTD001
MIFTS: 36

Foot Drop

Categories: Muscle diseases, Neuronal diseases

Aliases & Classifications for Foot Drop

MalaCards integrated aliases for Foot Drop:

Name: Foot Drop 53 6

Classifications:



Summaries for Foot Drop

NINDS : 53 Foot drop describes the inability to raise the front part of the foot due to weakness or paralysis of the muscles that lift the foot. As a result, individuals with foot drop scuff their toes along the ground or bend their knees to lift their foot higher than usual to avoid the scuffing, which causes what is called a “steppage” gait. Foot drop can be unilateral (affecting one foot) or bilateral (affecting both feet). Foot drop is a symptom of an underlying problem and is either temporary or permanent, depending on the cause. Causes include: neurodegenerative disorders of the brain that cause muscular problems, such as multiple sclerosis, stroke, and cerebral palsy; motor neuron disorders such as polio, some forms of spinal muscular atrophy and amyotrophic lateral sclerosis (commonly known as Lou Gehrig’s disease); injury to the nerve roots, such as in spinal stenosis; peripheral nerve disorders such as Charcot-Marie-Tooth disease or acquired peripheral neuropathy; local compression or damage to the peroneal nerve as it passes across the fibular bone below the knee; and muscle disorders, such as muscular dystrophy or myositis.

MalaCards based summary : Foot Drop is related to neuropathy, hereditary, with liability to pressure palsies and childhood-onset nemaline myopathy. An important gene associated with Foot Drop is DYSF (Dysferlin), and among its related pathways/superpathways is Striated Muscle Contraction. The drug Complement System Proteins has been mentioned in the context of this disorder. Affiliated tissues include spinal cord, bone marrow and bone, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 73 Foot drop is a gait abnormality in which the dropping of the forefoot happens due to weakness,... more...

Related Diseases for Foot Drop

Diseases related to Foot Drop via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 281)
# Related Disease Score Top Affiliating Genes
1 neuropathy, hereditary, with liability to pressure palsies 32.1 PMP22 MPZ
2 childhood-onset nemaline myopathy 31.8 NEB ACTA1
3 myopathy, myofibrillar, 9, with early respiratory failure 31.7 TTN NEB MYOT
4 nonaka myopathy 31.3 TTN MYOT DYSF
5 tibial muscular dystrophy 31.0 TTN NEB MYOT DYSF
6 charcot-marie-tooth disease 30.8 RAB33A PMP22 MPZ AIFM1
7 hereditary neuropathies 30.4 PMP22 MPZ
8 mononeuropathy 30.3 PMP22 MPZ
9 nerve compression syndrome 29.9 PMP22 MPZ
10 guillain-barre syndrome 29.8 PMP22 MPZ
11 carpal tunnel syndrome 29.8 PMP22 MPZ
12 autosomal dominant distal myopathy 29.7 TTN MYOT ACTA1
13 myositis 29.6 TTN NEB DYSF
14 neuropathy 29.6 TTN RAB33A PMP22 MPZ AIFM1
15 limb-girdle muscular dystrophy 29.5 TTN MYOT DYSF
16 miyoshi muscular dystrophy 29.5 TTN MYOT DYSF
17 batten-turner congenital myopathy 29.4 TTN NEB DYSF ACTA1
18 muscular dystrophy 29.2 TTN NEB MYOT FHL1 DYSF ACTA1
19 myopathy 28.9 TTN NEB MYOT FHL1 DYSF ACTA1
20 neuromuscular disease 28.6 TTN PMP22 NEB MYOT MPZ DYSF
21 facioscapulohumeral muscular dystrophy 1 11.2
22 peroneal nerve paralysis 11.1
23 cauda equina syndrome 11.1
24 charcot-marie-tooth disease and deafness 11.0
25 scapuloperoneal myopathy, x-linked dominant 11.0
26 hereditary motor and sensory neuropathy v 11.0
27 welander distal myopathy 11.0
28 spinal muscular atrophy, distal, autosomal recessive, 2 11.0
29 myopathy, scapulohumeroperoneal 11.0
30 developmental delay, impaired growth, dysmorphic facies, and axonal neuropathy 11.0
31 dysferlinopathy 11.0
32 distal myopathy with vocal cord weakness 11.0
33 multifocal motor neuropathy 11.0
34 radiculopathy 10.5
35 hansen's disease 10.5
36 leprosy 3 10.5
37 stroke, ischemic 10.4
38 multiple sclerosis 10.4
39 peroneal neuropathy 10.4
40 polyneuropathy 10.4
41 spinal stenosis 10.4
42 tooth disease 10.3
43 peripheral nervous system disease 10.3
44 cerebral palsy 10.3
45 back pain 10.3
46 hemiplegia 10.3
47 compartment syndrome 10.3
48 spasticity 10.3
49 herpes zoster 10.2
50 typical congenital nemaline myopathy 10.2 NEB ACTA1

Graphical network of the top 20 diseases related to Foot Drop:



Diseases related to Foot Drop

Symptoms & Phenotypes for Foot Drop

MGI Mouse Phenotypes related to Foot Drop:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.76 ACTA1 AIFM1 DYSF FHL1 MPZ NEB
2 homeostasis/metabolism MP:0005376 9.56 ACTA1 AIFM1 DYSF FHL1 MPZ NEB
3 muscle MP:0005369 9.17 ACTA1 AIFM1 DYSF FHL1 NEB PMP22

Drugs & Therapeutics for Foot Drop

Drugs for Foot Drop (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Complement System Proteins

Interventional clinical trials:

(show all 21)
# Name Status NCT ID Phase Drugs
1 Evaluation of the Safety and Performance of the NESS L300 Plus System Completed NCT01237860 Phase 3
2 Effect of Robot-assisted Training on Foot Drop in Multiple Sclerosis Completed NCT00872053 Phase 1, Phase 2
3 The Orthotic Effect of Functional Electrical Stimulation to Treat Foot Drop in People With MS Under Walking Conditions Simulating Those in Daily Life Unknown status NCT03410498
4 Evaluation of Usability and Human Factors in the Novus System Unknown status NCT02738242
5 Effects of Two Different Types of Ankle Foot Orthoses on Gait Outcomes in Patients With Subacute Stroke. Completed NCT02693834
6 Adaptive Ankle Robot Control System to Reduce Foot-drop in Chronic Stroke Completed NCT02483676
7 Functional Ambulation: Standard Treatment vs. Electronic Stimulation Therapy (FASTEST)Trial in Chronic Post-Stroke Subjects With Foot Drop Completed NCT01138995
8 A Pilot Study to Assess the Effects of Using FES or AFO as an Assistive Mobility for Period of 12 Weeks for People With Multiple Sclerosis With Foot Drop Completed NCT01977287
9 Association Between the Transcranial Direct Current Stimulation (tDCS) and Foot Drop Stimulation (FDS) for Gait Rehabilitation After Stroke - A Randomized Clinical Trial Completed NCT04077814
10 Functional Electrical Stimulation to Treat Foot Drop in People With Multiple Sclerosis Completed NCT02123537
11 Short-term Therapeutic Effects of Functional Electrical Stimulation Device Bioness L300 on the Somatosensory Cortical Representation in the Rehabilitation of Patients After Stroke Recruiting NCT04767360
12 Multi-pad Functional Electrical Stimulation for Droop Foot Treatment Enrolling by invitation NCT02729636
13 Portable Ankle Robotics to Reverse Foot Drop After Stroke Not yet recruiting NCT04594837
14 Walking Ankle Robot for Foot Drop in Aging and Disabled Populations: A Demonstration Project Not yet recruiting NCT03556709
15 A Prospective, Multi-center, Randomized, Parallel-group Controlled Trial to Compare Conservative Versus Surgical Treatment of Foot Drop in Peroneal Nerve Entrapment. Not yet recruiting NCT04695834
16 Seated Ankle Robot for Foot Drop in Aging and Disabled Populations: A Demonstration Project Not yet recruiting NCT03530592
17 A Wearable for Post-stroke Rehabilitative Multi-muscle Stimulation Inspired by the Natural Organization of Neuromuscular Control Not yet recruiting NCT04154514
18 The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute Lymphoblastic Leukemia and Foot Drop Terminated NCT01001390
19 Prospective Randomized Controlled Trial Comparing Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer. Terminated NCT01751503
20 Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty Withdrawn NCT02856958
21 TREAT Foot Drop After Stroke With Ankle Robot Withdrawn NCT04137809

Search NIH Clinical Center for Foot Drop

Genetic Tests for Foot Drop

Anatomical Context for Foot Drop

MalaCards organs/tissues related to Foot Drop:

40
Spinal Cord, Bone Marrow, Bone, Cortex, Skeletal Muscle, Prostate, Lymph Node

Publications for Foot Drop

Articles related to Foot Drop:

(show top 50) (show all 1307)
# Title Authors PMID Year
1
Functional electrical stimulation for foot drop in people with multiple sclerosis: The relevance and importance of addressing quality of movement. 61
32833562 2021
2
A rare case of parasagittal meningioma causing isolated foot drop: case report and review of the literature. 61
31786742 2021
3
Acute bilateral foot drop with or without cauda equina syndrome-a case series. 61
33550516 2021
4
Referral patterns for surgical consult in the management of patients with foot drop due to acute lumbar disc herniation: a survey study of physical therapists in the United States. 61
32530795 2021
5
Bilateral asymmetrical hip dislocations with acetabulum fractures; a case report. 61
33778147 2021
6
Arachnoid Web Fenestration: Diagnostic and Surgical Nuances. 61
33798776 2021
7
Systematic review of tendon transfers in the foot and ankle using interference screw fixation: Outcomes and safety of early versus standard postoperative rehabilitation. 61
33766498 2021
8
Foot Reanimation Using Double Nerve Transfer to Deep Peroneal Nerve: A Novel Technique for Treatment of Neurologic Foot Drop[Formula: see text]. 61
33787375 2021
9
Iatrogenic bilateral foot drop after uneventful cesarean section. 61
33780715 2021
10
Intraneural ganglion cysts of the peroneal nerve. 61
33651222 2021
11
Ganglion Cysts of the Proximal Tibiofibular Joint: Low Risk of Recurrence After Total Cyst Excision. 61
32773431 2021
12
Peripheral neuropathy due to neuroborreliosis: Insensitivity for CXCL13 as early diagnostic marker. 61
33684563 2021
13
Compartment syndrome: a rare complication following laparoscopic colorectal surgery. 61
33653860 2021
14
Bilateral common peroneal neuropathy due to rapid and marked weight loss after biliary surgery: A case report. 61
33748241 2021
15
Comparing soleus injections and gastrocnemius injections of botulinum toxin for treating adult spastic foot drop: a monocentric observational study. 61
33784844 2021
16
Mononeuropathy multiplex associated with systemic vasculitis: A case report. 61
33728320 2021
17
Basilar invagination: A mimicker of bulbar-onset amyotrophic lateral sclerosis. 61
33553704 2021
18
Immune-mediated neuromuscular complications of graft-versus-host disease. 61
33651380 2021
19
Short-Term Effect of Kinesio Taping of Lower-Leg Proprioceptive Neuromuscular Facilitation Pattern on Gait Parameter and Dynamic Balance in Chronic Stroke with Foot Drop. 61
33802448 2021
20
Brain Plasticity Mechanisms Underlying Motor Control Reorganization: Pilot Longitudinal Study on Post-Stroke Subjects. 61
33807679 2021
21
Clinical effectiveness of peroneal nerve functional electrical stimulation in chronic stroke patients with hemiplegia (PLEASURE): A multicentre, prospective, randomised controlled trial. 61
33103916 2021
22
Voluntary Control of an Ankle Joint Exoskeleton by Able-Bodied Individuals and Stroke Survivors Using EMG-Based Admittance Control Scheme. 61
32746072 2021
23
Current Concepts Review: Common Peroneal Nerve Palsy After Knee Dislocations. 61
33631968 2021
24
Reconstruction of acetabular defects greater than Paprosky type 3B: the importance of functional imaging. 61
33610170 2021
25
Bilateral traumatic distal femoral transphyseal fracture in a 9-year-old male. 61
33505660 2021
26
Adaptive Stimulation Profiles Modulation for Foot Drop Correction Using Functional Electrical Stimulation: A Proof of Concept Study. 61
32340970 2021
27
Foot drop after percutaneous treatment with radiopaque gelified ethanol (Discogel®). 61
32336588 2021
28
Single versus double tendon transfer for foot drop due to post-traumatic common fibular nerve palsy. 61
33475777 2021
29
Bilateral foot drop and cherry skin lesion. 61
33234390 2021
30
Risk factors for early and late failures following repair of urogenital fistulas. 61
33416963 2021
31
Anterior shin muscles CMAP measurements: Normal limits of symmetry and intra- and interobserver reliability. 61
33748551 2021
32
Response to: Two telemedicine consultants miss foot drop: when to see patients in person. 61
33598342 2021
33
Low Back Pain and Foot Drop Associated with Dog Tapeworm Infection. 61
33432916 2021
34
Fracture characteristics and outcomes of acetabular fracture management with minimally invasive approach and percutaneous fixation. 61
33512590 2021
35
Spinal ganglion cyst presenting with radiculopathy: diagnostic challenges and differential. 61
33468998 2021
36
Evaluation and Treatment of Foot Drop Using Nerve Transfer Techniques. 61
33220746 2021
37
Functional electrical stimulation compared with ankle-foot orthosis in subacute post stroke patients with foot drop: A pilot study. 61
30945999 2021
38
Functional electrical stimulation of the peroneal nerve improves post-stroke gait speed when combined with physiotherapy. A systematic review and meta-analysis. 61
32376404 2021
39
Functional Electrical Stimulation for Foot Drop in Post-Stroke People: Quantitative Effects on Step-to-Step Symmetry of Gait Using a Wearable Inertial Sensor. 61
33573046 2021
40
Cauda equina syndrome secondary to portal vein thrombosis: case report of favorable outcome with conservative treatment. 61
33386000 2021
41
Exercise-induced changes in gait kinematics in multiple sclerosis with minimal neurological disability. 61
33232909 2021
42
Extensive Perineural Spread of Subungual Melanoma. 61
32916345 2021
43
Trends and Technologies in Rehabilitation of Foot Drop: A Systematic Review. 61
33249938 2021
44
Peroneal Nerve Function Before and Following Surgical Excision of a Proximal Fibular Osteochondroma. 61
33003067 2021
45
Case Report: Systemic Small-Vessel Vasculitis in an Adolescent With Active Ulcerative Colitis. 61
33643972 2021
46
The Importance of Personally Reviewing Imaging for Clinical Correlation: A Case of Thoracic Spinal Stenosis Masquerading as a Motor Neuron Disease. 61
33315613 2020
47
Intracranial Mimics of Cauda Equina Syndrome: Heads or Tails? 61
32916368 2020
48
Scurvy presenting as lower limb ecchymoses in the setting of metastatic colorectal cancer. 61
33370932 2020
49
Ankle-foot orthoses and continuous functional electrical stimulation improve walking speed after stroke: a systematic review and meta-analyses of randomized controlled trials. 61
33120054 2020
50
The relationship between pain and herniation radiology in giant lumbar disc herniation causing severe sciatica: 15 cases. 61
33356636 2020

Variations for Foot Drop

ClinVar genetic disease variations for Foot Drop:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 DYSF NM_001130987.2(DYSF):c.2524del (p.Cys842fs) Deletion Pathogenic 523461 rs1553551006 GRCh37: 2:71791302-71791302
GRCh38: 2:71564172-71564172
2 MYOT NM_006790.2(MYOT):c.164C>T (p.Ser55Phe) SNV Pathogenic 5835 rs121908457 GRCh37: 5:137206504-137206504
GRCh38: 5:137870815-137870815
3 overlap with 6 genes GRCh37/hg19 17p12(chr17:14215739-15422582) copy number loss Pathogenic 523238 GRCh37: 17:14215739-15422582
GRCh38:
4 RAB33A , AIFM1 NM_004208.4(AIFM1):c.1019T>C (p.Met340Thr) SNV Likely pathogenic 374094 rs1057518895 GRCh37: X:129271109-129271109
GRCh38: X:130137134-130137134
5 AARS1 NM_001605.2(AARS1):c.2054T>C (p.Val685Ala) SNV Uncertain significance 523443 rs1555539904 GRCh37: 16:70292059-70292059
GRCh38: 16:70258156-70258156

Expression for Foot Drop

Search GEO for disease gene expression data for Foot Drop.

Pathways for Foot Drop

Pathways related to Foot Drop according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 TTN NEB ACTA1

GO Terms for Foot Drop

Cellular components related to Foot Drop according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 actin cytoskeleton GO:0015629 9.33 NEB MYOT ACTA1
2 sarcomere GO:0030017 9.26 NEB ACTA1
3 Z disc GO:0030018 9.13 TTN NEB MYOT
4 striated muscle thin filament GO:0005865 8.62 TTN ACTA1

Biological processes related to Foot Drop according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 skeletal muscle thin filament assembly GO:0030240 9.16 TTN ACTA1
2 muscle filament sliding GO:0030049 9.13 TTN NEB ACTA1
3 muscle contraction GO:0006936 8.92 TTN MYOT DYSF ACTA1

Molecular functions related to Foot Drop according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of muscle GO:0008307 8.8 TTN NEB MYOT

Sources for Foot Drop

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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