Aliases & Classifications for Foot Drop

MalaCards integrated aliases for Foot Drop:

Name: Foot Drop 54

Summaries for Foot Drop

NINDS : 54 Foot drop describes the inability to raise the front part of the foot due to weakness or paralysis of the muscles that lift the foot. As a result, individuals with foot drop scuff their toes along the ground or bend their knees to lift their foot higher than usual to avoid the scuffing, which causes what is called a “steppage” gait. Foot drop can be unilateral (affecting one foot) or bilateral (affecting both feet). Foot drop is a symptom of an underlying problem and is either temporary or permanent, depending on the cause. Causes include: neurodegenerative disorders of the brain that cause muscular problems, such as multiple sclerosis, stroke, and cerebral palsy; motor neuron disorders such as polio, some forms of spinal muscular atrophy and amyotrophic lateral sclerosis (commonly known as Lou Gehrig’s disease); injury to the nerve roots, such as in spinal stenosis; peripheral nerve disorders such as Charcot-Marie-Tooth disease or acquired peripheral neuropathy; local compression or damage to the peroneal nerve as it passes across the fibular bone below the knee; and muscle disorders, such as muscular dystrophy or myositis.

MalaCards based summary : Foot Drop is related to childhood-onset nemaline myopathy and charcot-marie-tooth disease and deafness. An important gene associated with Foot Drop is ACTA1 (Actin, Alpha 1, Skeletal Muscle), and among its related pathways/superpathways are Neural Crest Differentiation and Striated Muscle Contraction. The drugs Bupivacaine and Anesthetics have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related phenotypes are behavior/neurological and homeostasis/metabolism

Wikipedia : 76 Foot drop is a gait abnormality in which the dropping of the forefoot happens due to weakness,... more...

Related Diseases for Foot Drop

Diseases related to Foot Drop via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 120)
# Related Disease Score Top Affiliating Genes
1 childhood-onset nemaline myopathy 31.6 ACTA1 NEB
2 charcot-marie-tooth disease and deafness 30.9 MPZ PMP22
3 myopathy, congenital 29.6 ACTA1 NEB
4 hereditary neuropathy with liability to pressure palsy 29.5 MPZ PMP22
5 neuropathy, hereditary, with liability to pressure palsies 29.4 MPZ PMP22
6 hereditary neuropathies 29.4 MPZ PMP22
7 neuromuscular disease 29.2 MPZ PMP22
8 peripheral nervous system disease 28.9 MPZ PMP22
9 polyneuropathy 28.9 MPZ PMP22
10 tooth disease 28.4 MPZ PMP22
11 myopathy 28.1 ACTA1 FHL1 NEB
12 charcot-marie-tooth disease 11.3
13 welander distal myopathy, swedish type 10.9
14 myopathy, scapulohumeroperoneal 10.9
15 cauda equina syndrome 10.9
16 scapuloperoneal myopathy, x-linked dominant 10.9
17 multifocal motor neuropathy 10.9
18 neuropathy 10.2
19 scapuloperoneal myopathy 10.2 ACTA1 FHL1
20 intermediate congenital nemaline myopathy 10.2 ACTA1 NEB
21 typical congenital nemaline myopathy 10.2 ACTA1 NEB
22 severe congenital nemaline myopathy 10.2 ACTA1 NEB
23 congenital structural myopathy 10.1 ACTA1 NEB
24 rigid spine muscular dystrophy 1 10.1 ACTA1 FHL1
25 multiple sclerosis 10.1
26 cerebritis 10.1
27 spasticity 10.1
28 reducing body myopathy 10.0 FHL1 NEB
29 lymphoma 10.0
30 herpes zoster 9.9
31 vasculitis 9.9
32 syringomyelia 9.9
33 purpura 9.9
34 peroneal neuropathy 9.9
35 radiculopathy 9.9
36 stroke, ischemic 9.9
37 nemaline myopathy 9.9 ACTA1 NEB
38 congenital hypomyelination neuropathy 9.8 MPZ PMP22
39 charcot-marie-tooth neuropathy type 1 9.8 MPZ PMP22
40 vacuolar neuromyopathy 9.8
41 spinal stenosis 9.8
42 compartment syndrome 9.8
43 anorexia nervosa 9.8
44 endometriosis 9.8
45 rheumatoid vasculitis 9.8
46 aneurysm 9.8
47 prostate cancer 9.8
48 back pain 9.8
49 cerebral palsy 9.8
50 muscular dystrophy 9.8

Graphical network of the top 20 diseases related to Foot Drop:



Diseases related to Foot Drop

Symptoms & Phenotypes for Foot Drop

MGI Mouse Phenotypes related to Foot Drop:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.55 MPZ NEB PMP22 ACTA1 FHL1
2 homeostasis/metabolism MP:0005376 9.35 ACTA1 FHL1 MPZ NEB PMP22
3 muscle MP:0005369 8.92 ACTA1 FHL1 NEB PMP22

Drugs & Therapeutics for Foot Drop

Drugs for Foot Drop (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
2 Anesthetics Phase 3,Not Applicable,Early Phase 1
3 Central Nervous System Depressants Phase 3,Not Applicable
4 Anesthetics, Local Phase 3,Early Phase 1,Not Applicable
5 Peripheral Nervous System Agents Phase 3,Not Applicable
6
Menthol Approved Not Applicable 2216-51-5 16666
7
Mepivacaine Approved, Vet_approved Not Applicable 96-88-8 4062
8
Levobupivacaine Approved, Investigational Not Applicable 27262-47-1 92253
9
Ropivacaine Approved Not Applicable 84057-95-4 71273 175805
10 Complement System Proteins Not Applicable

Interventional clinical trials:

(show all 45)
# Name Status NCT ID Phase Drugs
1 Effects of Functional Electrical Stimulation on Gait in Children With Cerebral Palsy Unknown status NCT02462018 Phase 4
2 Evaluation of the Safety and Performance of the NESS L300 Plus System Completed NCT01237860 Phase 3
3 0.25% Bupivacaine Versus a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka Not yet recruiting NCT03303794 Phase 3 Exparel;0.25% bupivacaine
4 Effect of Robot-assisted Training on Foot Drop in Multiple Sclerosis Completed NCT00872053 Phase 1, Phase 2
5 Targeted Lower Extremity Joint Training Terminated NCT00765544 Phase 1, Phase 2
6 Pilot Study Assessing the Feasibility of Treating Foot Drop With the Neurostep™ System. Completed NCT00860210 Phase 1
7 Evaluation of Usability and Human Factors in the Novus System Unknown status NCT02738242 Not Applicable
8 Pairing Functional Electrical Stimulation (FES) and Volitional Effort Training Promotes Neuroplasticity and Motor Gain Unknown status NCT02797886 Not Applicable
9 Comparison of Different Treatment Methods for Gait Rehabilitation of Sub-Acute Post Stroke Patients With Dropped Foot Unknown status NCT01876030 Not Applicable
10 Treating Foot Drop in People With Multiple Sclerosis Using Electrical Stimulation Completed NCT02123537 Not Applicable
11 Walking With FES or AFO in People With MS With Foot Drop Completed NCT01977287
12 Evaluation of Dual Channel vs. Single Channel FES for Dropfoot Completed NCT02494323 Not Applicable
13 Clinical Study of the L300 Versus Ankle-foot Orthosis (AFO) on Post-Stroke Subjects With Foot Drop Completed NCT01138995 Not Applicable
14 Functional Electrical Stimulation for Footdrop in Hemiparesis Completed NCT00148343 Not Applicable
15 Functional Electrical Stimulation for People With Multiple Sclerosis Who Experience Foot Drop Completed NCT01914016 Not Applicable
16 Clinical Study to Evaluate the Implantation of the ActiGait Drop Foot Stimulator System Completed NCT01116466 Not Applicable
17 Implanted Drop Foot Stimulator for Hemiparetic Patients Completed NCT03447717 Not Applicable
18 Effect of FES Interventions on Gait Dynamics in Stroke Population Completed NCT01952613 Not Applicable
19 Tibial Nerve Versus Sciatic Nerve Block Completed NCT01415193 Not Applicable
20 Functional Electrical Stimulation Mediated Neuroplasticity: Lower Extremity CCNMES in Stroke Completed NCT02199795 Not Applicable
21 Effects of Targeted Lower Extremity Joint Training on Multiple Sclerosis (MS) Gait Abnormalities Completed NCT00906737 Not Applicable
22 WalkAide Compared to Ankle-Foot Orthosis (AFO) in Stroke Patients Completed NCT01087957 Not Applicable
23 Parameter Changes in Functional Electrical Stimulation Completed NCT03300986
24 Approach to Continuous Sciatic Nerve Block for Orthopedic Procedures in Day Surgery With Two Different Techniques Completed NCT02029404 Not Applicable
25 Efficacy of the WalkAide and AFOs for CVA Completed NCT00216320 Not Applicable
26 Clinical Effects of Peroneal Nerve Functional Electrical Stimulation (WalkAide[R]) for Chronic Stroke Patients Completed NCT02897752 Not Applicable
27 Comparison Between Implanted Functional Electrical Stimulation and Foot Orthosis Completed NCT01415700 Not Applicable
28 Interactive Exoskeleton Robot for Walking - Ankle Joint Completed NCT02471248 Not Applicable
29 Electrical Stimulation for Recovery of Ankle Dorsiflexion in Chronic Stroke Survivors Completed NCT01029912 Not Applicable
30 Ankle Robot to Reduce Foot Drop in Stroke Recruiting NCT02483676 Not Applicable
31 Multi-pad FES System for Drop Foot Treatment Recruiting NCT02729636 Early Phase 1
32 Effects of Two Different Types of Ankle Foot Orthoses on Gait Outcomes in Patients With Subacute Stroke. Recruiting NCT02693834 Not Applicable
33 Implementation of Fast-track Surgery Program for Total Hip and Knee Replacement and the Evaluation of the Risks and Benefits for the Patient Recruiting NCT03028779 Not Applicable
34 Spinal Cord Stimulation to Augment Activity Based Therapy Recruiting NCT03240601 Not Applicable
35 Development of Charcot Marie Tooth Disease (CMT) Pediatric Scale for Children With CMT Recruiting NCT01203085
36 Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer Active, not recruiting NCT01751503 Not Applicable
37 Walking Ankle Robot for Foot Drop in Aging and Disabled Populations: A Demonstration Project Not yet recruiting NCT03556709 Not Applicable
38 Seated Ankle Robot for Foot Drop in Aging and Disabled Populations: A Demonstration Project Not yet recruiting NCT03530592 Not Applicable
39 The Effects of FES in a Variety of Walking Conditions in People With MS Not yet recruiting NCT03410498 Not Applicable
40 Functional Electrical Stimulation During Walking in Cerebral Palsy Not yet recruiting NCT03440632 Not Applicable
41 Tuned Versus Untuned Ankle-foot Orthoses in Children and Adolescents With Cerebral Palsy Not yet recruiting NCT03547674 Not Applicable
42 The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute Lymphoblastic Leukemia and Foot Drop Terminated NCT01001390 Not Applicable
43 Continuous Femoral and Tibial Nerve Blocks in TKA Patients Terminated NCT01680692 Early Phase 1 Ropivicaine
44 Continuous Lumbar Plexus Block With and Without Parasacral Block in Patients Undergoing Total Hip Replacement Terminated NCT02161484 Not Applicable Ropivacine 0.2%;Bupivacaine 0.0625%
45 Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty Withdrawn NCT02856958 Not Applicable

Search NIH Clinical Center for Foot Drop

Genetic Tests for Foot Drop

Anatomical Context for Foot Drop

MalaCards organs/tissues related to Foot Drop:

41
Brain, Bone, Spinal Cord, Prostate, B Cells, Myeloid, Skin

Publications for Foot Drop

Articles related to Foot Drop:

(show top 50) (show all 346)
# Title Authors Year
1
Functional electrical stimulation and ankle foot orthoses provide equivalent therapeutic effects on foot drop: A meta-analysis providing direction for future research. ( 29227525 )
2018
2
External neurolysis as a treatment for foot drop secondary to weight loss: a retrospective analysis of 200 cases. ( 29961126 )
2018
3
Risk Factors Analysis for Foot Drop Associated with Lumbar Disc Herniation: An Analysis of 236 Patients. ( 29223521 )
2018
4
Metachronous Bilateral Painless Foot Drop Secondary to Spinal Stenosis: Case Report. ( 29736360 )
2018
5
Foot drop caused by a movable cystic mass during knee motion. ( 29562484 )
2018
6
Strength of Interference Screw Fixation to Cuboid vs Pulvertaft Weave to Peroneus Brevis for Tibialis Posterior Tendon Transfer for Foot Drop. ( 29582684 )
2018
7
Acute Bilateral Isolated Foot Drop: Changing the Paradigm in Management of Degenerative Spine Surgery with Percutaneous Endoscopy. ( 29191530 )
2018
8
Letter to the Editor re: You're the Flight Surgeon: Foot Drop: Letter. ( 29789093 )
2018
9
Usability of the Thera-BandAr to improve foot drop in stroke survivors. ( 29660954 )
2018
10
Bipedal gait model for precise gait recognition and optimal triggering in foot drop stimulator: a proof of concept. ( 29524118 )
2018
11
Chiari malformation type 1 presenting as unilateral progressive foot drop: a case report and review of literature. ( 29415676 )
2018
12
Irreversible Foot Drop as a Consequence of Neglected Knee Pain in an Adolescent with a Peroneal Intraneural Ganglion Cyst. ( 29309980 )
2018
13
Letter to the Editor re: You're the Flight Surgeon: Foot Drop: Response. ( 29789092 )
2018
14
Peripheral Neuropathy Due to Recreational Use of Nitrous Oxide Presenting After an Ankle Sprain With Foot Drop. ( 29120005 )
2017
15
A decision support system for electrode shaping in multi-pad FES foot drop correction. ( 28673311 )
2017
16
Immediate effects of ankle eversion taping on dynamic and static balance of chronic stroke patients with foot drop. ( 28626316 )
2017
17
The effect of newly designed multi joint ankle foot orthosis on the gait and dynamic balance of stroke patients with foot drop. ( 29200619 )
2017
18
Does a foot-drop implant improve kinetic and kinematic parameters in the foot and ankle? ( 28220261 )
2017
19
Functional Electrical Stimulation for Foot Drop in Multiple Sclerosis: A Systematic Review and Meta-Analysis of the Effect on Gait Speed. ( 28088382 )
2017
20
External revascularisation for pseudochronic total occlusion of the dorsal pedis artery due to foot drop with severe diabetes mellitus. ( 28710243 )
2017
21
An Unexpected Reason for Isolated Foot Drop: Acute Stroke. ( 29142581 )
2017
22
First Case of Foot Drop Associated with Capecitabine in a Patient with Thymidylate Synthase Polymorphism. ( 28280649 )
2017
23
Gait Improvements After Peroneal or Tibial Nerve Transfer in Patients with Foot Drop: A Retrospective Study. ( 29018508 )
2017
24
Asthma, Foot Drop, and Palpable Purpura in a Young Woman. ( 28620827 )
2017
25
Acute Bilateral Foot Drop as a Presenting Symptom of Hemorrhagic Synovial Cyst of the Lumbar Spine. ( 28951268 )
2017
26
Flexor Hallucis Longus Transfer for Foot Drop without Functioning Tibialis Posterior. ( 29351531 )
2017
27
Dual lumbar bronchogenic and arachnoid cyst presenting with sciatica and left foot drop. ( 28762109 )
2017
28
Differential diagnosis and recovery of acute bilateral foot drop in a patient with a history of low back pain: A case report. ( 28509608 )
2017
29
Malignant Triton tumor: a rare cause of sciatic pain and foot drop. ( 28884110 )
2017
30
Alterations in Spectral Attributes of Surface Electromyograms after Utilization of a Foot Drop Stimulator during Post-Stroke Gait. ( 28900414 )
2017
31
Transcranial Motor Evoked Potential Alarm Criteria To Predict Foot Drop Injury During Lumbosacral Surgery. ( 28614281 )
2017
32
High-Stepping Cross-Country Athlete: A Unique Case of Foot Drop and a Novel Treatment Approach. ( 28902752 )
2017
33
Intraneural ganglion cyst of the external popliteal sciatic nerve: A possible cause of foot drop. ( 28427770 )
2017
34
Functional Outcomes Following Anterior Transfer of the Tibialis Posterior Tendon for Foot Drop Secondary to Peroneal Nerve Palsy. ( 28552040 )
2017
35
Walking measures to evaluate assistive technology for foot drop in multiple sclerosis: A systematic review of psychometric properties. ( 29304511 )
2017
36
Effects of biofeedback versus switch-triggered functional electrical stimulation on sciatica-related foot drop. ( 28946515 )
2017
37
Peroneal Intraneural Ganglia Formation Causing Foot Drop in Children: A Clinical Perspective. ( 26721618 )
2016
38
Cat Bite: An Unusual Cause of Foot Drop. ( 26836381 )
2016
39
Feasibility of Using Lokomat Combined with Functional Electrical Stimulation for the Rehabilitation of Foot Drop. ( 27990246 )
2016
40
Progressive foot drop caused by below-knee compression stocking after spinal surgery. ( 27617106 )
2016
41
A Modified Approach of Percutaneous Endoscopic Lumbar Discectomy (PELD) for Far Lateral Disc Herniation at L5-S1 with Foot Drop. ( 26839673 )
2016
42
Surgical outcome of foot drop caused by common peroneal nerve injuries; is the glass half full or half empty? ( 27106843 )
2016
43
Foot drop of central origin: a misleading alteration of nerve conduction study. ( 26728269 )
2016
44
An Unusual Presentation of Right-Sided Sciatica with Foot Drop. ( 27217963 )
2016
45
Functional electrical stimulation versus ankle foot orthoses for foot-drop: A meta-analysis of orthotic effects. ( 27563700 )
2016
46
A Case of Alkaptonuria with Degenerative Collagenous Plaques and Foot Drop. ( 27904192 )
2016
47
Foot drop following closed reduction of a total hip replacement. ( 27005799 )
2016
48
An Unusual Cause of Foot Drop: Peroneal Extraneural Ganglion Cyst. ( 27648065 )
2016
49
An Unusual Postoperative Neuropathy: Foot Drop Contralateral to the Lateral Decubitus Position. ( 27580410 )
2016
50
Total Hip Arthroplasty Complicated by a Gluteal Hematoma Resulting in Acute Foot Drop. ( 26966944 )
2016

Variations for Foot Drop

Expression for Foot Drop

Search GEO for disease gene expression data for Foot Drop.

Pathways for Foot Drop

Pathways related to Foot Drop according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 MPZ PMP22
2 10.48 ACTA1 NEB

GO Terms for Foot Drop

Cellular components related to Foot Drop according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sarcomere GO:0030017 8.62 ACTA1 NEB

Biological processes related to Foot Drop according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle organ development GO:0007517 9.16 FHL1 NEB
2 myelination GO:0042552 8.96 MPZ PMP22
3 muscle filament sliding GO:0030049 8.62 ACTA1 NEB

Sources for Foot Drop

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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