Aliases & Classifications for Foot Drop

MalaCards integrated aliases for Foot Drop:

Name: Foot Drop 53


Summaries for Foot Drop

NINDS : 53 Foot drop describes the inability to raise the front part of the foot due to weakness or paralysis of the muscles that lift the foot. As a result, individuals with foot drop scuff their toes along the ground or bend their knees to lift their foot higher than usual to avoid the scuffing, which causes what is called a “steppage” gait. Foot drop can be unilateral (affecting one foot) or bilateral (affecting both feet). Foot drop is a symptom of an underlying problem and is either temporary or permanent, depending on the cause. Causes include: neurodegenerative disorders of the brain that cause muscular problems, such as multiple sclerosis, stroke, and cerebral palsy; motor neuron disorders such as polio, some forms of spinal muscular atrophy and amyotrophic lateral sclerosis (commonly known as Lou Gehrig’s disease); injury to the nerve roots, such as in spinal stenosis; peripheral nerve disorders such as Charcot-Marie-Tooth disease or acquired peripheral neuropathy; local compression or damage to the peroneal nerve as it passes across the fibular bone below the knee; and muscle disorders, such as muscular dystrophy or myositis.

MalaCards based summary : Foot Drop is related to neuropathy, hereditary, with liability to pressure palsies and myopathy, myofibrillar, 9, with early respiratory failure. An important gene associated with Foot Drop is ACTA1 (Actin Alpha 1, Skeletal Muscle), and among its related pathways/superpathways are Neural Crest Differentiation and Striated Muscle Contraction. The drugs Bupivacaine and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and spinal cord, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 74 Foot drop is a gait abnormality in which the dropping of the forefoot happens due to weakness,... more...

Related Diseases for Foot Drop

Diseases related to Foot Drop via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 242)
# Related Disease Score Top Affiliating Genes
1 neuropathy, hereditary, with liability to pressure palsies 32.4 PMP22 MPZ
2 myopathy, myofibrillar, 9, with early respiratory failure 31.8 TTN NEB
3 childhood-onset nemaline myopathy 31.6 NEB ACTA1
4 tibial muscular dystrophy 31.4 TTN NEB
5 charcot-marie-tooth disease and deafness 30.9 PMP22 MPZ
6 hereditary neuropathies 30.0 PMP22 MPZ
7 mononeuropathy 29.9 PMP22 MPZ
8 neuritis 29.8 PMP22 MPZ
9 nemaline myopathy 29.5 NEB ACTA1
10 guillain-barre syndrome 29.5 PMP22 MPZ
11 carpal tunnel syndrome 29.4 PMP22 MPZ
12 neurilemmoma 29.4 PMP22 MPZ
13 sensory peripheral neuropathy 29.3 PMP22 MPZ
14 miyoshi muscular dystrophy 29.0 TTN NEB
15 muscular dystrophy 29.0 TTN NEB FHL1 ACTA1
16 myopathy, congenital 28.9 TTN NEB ACTA1
17 myopathy 28.7 TTN NEB FHL1 ACTA1
18 neuromuscular disease 28.0 TTN PMP22 NEB MPZ ACTA1
19 peroneal nerve paralysis 11.6
20 charcot-marie-tooth disease 11.6
21 cauda equina syndrome 11.5
22 facioscapulohumeral muscular dystrophy 1 11.5
23 scapuloperoneal myopathy, x-linked dominant 11.2
24 hereditary motor and sensory neuropathy v 11.2
25 welander distal myopathy 11.2
26 spinal muscular atrophy, distal, autosomal recessive, 2 11.2
27 myopathy, scapulohumeroperoneal 11.2
28 dysferlinopathy 11.2
29 distal myopathy with vocal cord weakness 11.2
30 multifocal motor neuropathy 11.2
31 neuropathy 10.5
32 hansen's disease 10.5
33 radiculopathy 10.5
34 leprosy 3 10.5
35 peroneal neuropathy 10.3
36 spinal stenosis 10.3
37 tooth disease 10.3
38 polyneuropathy 10.3
39 peripheral nervous system disease 10.3
40 cerebral palsy 10.2
41 compartment syndrome 10.2
42 stroke, ischemic 10.2
43 hemiplegia 10.2
44 herpes zoster 10.2
45 back pain 10.2
46 sciatic neuropathy 10.2
47 vasculitis 10.2
48 aneurysm 10.2
49 spasticity 10.2
50 scapuloperoneal myopathy 10.1 FHL1 ACTA1

Graphical network of the top 20 diseases related to Foot Drop:

Diseases related to Foot Drop

Symptoms & Phenotypes for Foot Drop

MGI Mouse Phenotypes related to Foot Drop:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 ACTA1 FHL1 MPZ NEB PMP22 TTN
2 growth/size/body region MP:0005378 9.63 ACTA1 FHL1 MPZ NEB PMP22 TTN
3 homeostasis/metabolism MP:0005376 9.43 ACTA1 FHL1 MPZ NEB PMP22 TTN
4 muscle MP:0005369 9.02 ACTA1 FHL1 NEB PMP22 TTN

Drugs & Therapeutics for Foot Drop

Drugs for Foot Drop (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Bupivacaine Approved, Investigational Phase 3 2180-92-9, 38396-39-3 2474
2 Anesthetics, Local Phase 3
3 Anesthetics Phase 3
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
Ropivacaine Approved Early Phase 1 84057-95-4 71273 175805
Levobupivacaine Approved, Investigational 27262-47-1 92253
Mepivacaine Approved, Vet_approved 96-88-8 4062
8 Complement System Proteins

Interventional clinical trials:

(show all 48)
# Name Status NCT ID Phase Drugs
1 Effects of Functional Electrical Stimulation on Gait in Children With Hemiplegic and Diplegic Cerebral Palsy Unknown status NCT02462018 Phase 4
2 Evaluation of the Safety and Performance of the NESS L300 Plus System Completed NCT01237860 Phase 3
3 Comparative Feasibility and Efficacy of a Five Compartment Technique Using 0.25% Bupivacaine vs a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka; a Single Blinded Randomized Controlled Study Terminated NCT03303794 Phase 3 Exparel;0.25% bupivacaine
4 Effect of Robot-assisted Training on Foot Drop in Multiple Sclerosis Completed NCT00872053 Phase 1, Phase 2
5 An Open-Label Phase 2 Study of ManNAc in Subjects With GNE Myopathy Completed NCT02346461 Phase 2 ManNAc;ManNAc
6 Robot-assisted Ankle Rehabilitation for Multiple Sclerosis (Anklebot) Terminated NCT00765544 Phase 1, Phase 2
7 Pilot Feasibility Study of the Neurostep™ System in Subjects With Gait Disorder Secondary to CNS Lesion. Completed NCT00860210 Phase 1
8 The Orthotic Effect of Functional Electrical Stimulation to Treat Foot Drop in People With MS Under Walking Conditions Simulating Those in Daily Life Unknown status NCT03410498
9 Evaluation of Usability and Human Factors in the Novus System Unknown status NCT02738242
10 Pairing Functional Electrical Stimulation (FES) and Volitional Effort Training Promotes Neuroplasticity and Motor Gain Unknown status NCT02797886
11 Functional Electrical Stimulation to Treat Foot Drop in People With Multiple Sclerosis Completed NCT02123537
12 Targeted Lower Extremity Joint Training Effects on MS Gait Abnormalities Completed NCT00906737
13 Functional Electrical Stimulation for People With Multiple Sclerosis Who Experience Foot Drop:Feasibility of Instrumented Gait Analysis in Clinical Practice. Completed NCT01914016
14 Adaptive Ankle Robot Control System to Reduce Foot-drop in Chronic Stroke Completed NCT02483676
15 Randomized Trial of the Innovative Neurotronics WalkAide Compared to Conventional Ankle-Foot Orthosis (AFO) in Stroke Patients (INSTRIDE) Completed NCT01087957
16 Identification of Responders to the FES Interventions in Stroke Population Completed NCT01952613
17 Functional Electrical Stimulation for Footdrop in Hemiparesis Completed NCT00148343
18 A Pilot Study to Assess the Effects of Using FES or AFO as an Assistive Mobility for Period of 12 Weeks for People With Multiple Sclerosis With Foot Drop Completed NCT01977287
19 Parameter Changes in Functional Electrical Stimulation Completed NCT03300986
20 A Three-Arm, Randomized Crossover Study Comparing the Innovative Neurotronics WalkAide™ System to Ankle-Foot Orthosis [AFO] Completed NCT00216320
21 The Therapeutic Effects of Peroneal Nerve Functional Electrical Stimulation for Lower Extremity in Patients With Sub-acute Post-stroke Hemiplegia A Randomized Controlled Study Completed NCT02898168
22 Functional Ambulation: Standard Treatment vs. Electronic Stimulation Therapy (FASTEST)Trial in Chronic Post-Stroke Subjects With Foot Drop Completed NCT01138995
23 Implanted Functional Electrical Stimulation of the Levators of the Ankle Versus Orthosis in the Treatment of Chronic Foot Neurological STEPPAGE-gait by Central Attack Completed NCT01415700
24 Clinical Effects of Peroneal Nerve Functional Electrical Stimulation (WalkAide[R]) for the Lower Extremities in Chronic Stroke Patients With Hemiplegia: A Multicenter, Prospective, Randomized Controlled Trial Completed NCT02897752
25 Effects of Two Different Types of Ankle Foot Orthoses on Gait Outcomes in Patients With Subacute Stroke. Completed NCT02693834
26 Clinical Study to Evaluate the Implantation of the ActiGait Drop Foot Stimulator System Completed NCT01116466
27 Do Patients Who Receive the IPACK and Adductor Canal Catheter Have Better Outcomes Than Patients Receiving the Adductor Canal Catheter Alone for Total Knee Replacements? Completed NCT03774966 Early Phase 1
28 Approach to Continuous Sciatic Nerve Block for Orthopedic Procedures in Day Surgery With Two Different Techniques Completed NCT02029404
29 The Evaluation of Dual Channel vs Single Channel FES for Dropfoot Completed NCT02494323
30 The Effect of Functional Electrical Stimulation Technology on Gait and Balance Performance in Children With Hemiplegic Cerebral Palsy Recruiting NCT04269798
31 Wearable Interactive Lower-limb Exoskeleton Robotic Device for Gait Training of Post-stroke Patients on Different Walking Conditions Recruiting NCT03184259
32 Brain Computer Interface - Functional Electrical Stimulation (BCI-FES) Therapy for Stroke Rehabilitation Recruiting NCT04279067
33 A Rigid Body Database on Human Movement Recruiting NCT00001252
34 Association Between the Transcranial Direct Current Stimulation (tDCS) and Foot Drop Stimulation (FDS) for Gait Rehabilitation After Stroke - A Randomized Clinical Trial Active, not recruiting NCT04077814
35 The Effect of Neuro-orthosis on Gait Performer in Chronic Post Stroke Subjects Active, not recruiting NCT04266899
36 Multi-pad Functional Electrical Stimulation for Droop Foot Treatment Enrolling by invitation NCT02729636
37 Walking Ankle Robot for Foot Drop in Aging and Disabled Populations: A Demonstration Project Not yet recruiting NCT03556709
38 Seated Ankle Robot for Foot Drop in Aging and Disabled Populations: A Demonstration Project Not yet recruiting NCT03530592
39 Comparison of Thermo-plastic Versus Carbon Foot Ankle Orthosis to Improve Gait and Reduce Fatigue in Post-stroke Patients: a Biomechanical and Neurophysiological Study Not yet recruiting NCT04323943
40 TREAT Foot Drop After Stroke With Ankle Robot Not yet recruiting NCT04137809
41 Influence of Whole Body Vibration on Neuromodulation of Ankle Muscles in Persons With SCI Not yet recruiting NCT04238013
42 Effects of Focal Muscle Vibration on Upper Limb Function in Subacute Post-stroke Patients Not yet recruiting NCT04289766
43 A Wearable for Post-stroke Rehabilitative Multi-muscle Stimulation Inspired by the Natural Organization of Neuromuscular Control Not yet recruiting NCT04154514
44 Use Of Autologous Stem Cell Use In Neurological Non-neoplastic Disorders And Disease Not yet recruiting NCT03297177
45 The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute Lymphoblastic Leukemia and Foot Drop Terminated NCT01001390
46 Prospective Randomized Controlled Trial Comparing Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer. Terminated NCT01751503
47 A Prospective, Randomized Study Comparing Continuous Femoral and Tibial Nerve Blocks vs. Continuous Femoral and Single Shot Sciatic Nerve Block in Total Knee Arthroplasties. Terminated NCT01680692 Early Phase 1 Ropivicaine
48 Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty Withdrawn NCT02856958

Search NIH Clinical Center for Foot Drop

Genetic Tests for Foot Drop

Anatomical Context for Foot Drop

MalaCards organs/tissues related to Foot Drop:

Brain, Bone, Spinal Cord, Liver, Testes, T Cells, Bone Marrow

Publications for Foot Drop

Articles related to Foot Drop:

(show top 50) (show all 1218)
# Title Authors PMID Year
Clinical characteristics of fibroblast growth factor receptor 3 antibody-related polyneuropathy: a retrospective study. 61
32068339 2020
Case report of eventration of diaphragm due to an unknown febrile illness causing phrenic nerve palsy and other multiple nerve palsies. 61
32382413 2020
Referral patterns for surgical consult in the management of patients with foot drop due to acute lumbar disc herniation: a survey study of physical therapists in the United States. 61
32530795 2020
Iterative Adjustment of Stimulation Timing and Intensity During FES-Assisted Treadmill Walking for Patients After Stroke. 61
32275602 2020
Effects of two different types of ankle-foot orthoses on gait outcomes in patients with subacute stroke: a randomized crossover trial. 61
32573271 2020
Functional electrical stimulation of the peroneal nerve improves post-stroke gait speed when combined with physiotherapy. A systematic review and meta-analysis. 61
32376404 2020
Inertial measurement unit compared to an optical motion capturing system in post-stroke individuals with foot-drop syndrome. 61
31009801 2020
Randomized comparison of functional electric stimulation in posturally corrected position and motor program activating therapy: treating foot drop in people with multiple sclerosis. 61
32383574 2020
Functional outcome in giant cell tumor of distal radius treated with excision and fibular arthroplasty: a case series. 61
32358713 2020
[Effectiveness of tibialis posterior tendon transfer for foot drop secondary to peroneal nerve palsy]. 61
32410426 2020
Conditioning Electrical Stimulation Accelerates Regeneration in Nerve Transfers. 61
32447758 2020
Foot Drop After Iliocaval Vein Stenting: Radicular Syndrome from Stent Misplacement in Spinal Canal. 61
31954898 2020
Tibialis posterior (TP) tendon transfer for foot drop: A single center experience. 61
32405209 2020
Thrombotic microangiopathy involving kidney allograft and peripheral nerves. 61
31816173 2020
Identifying Common Peroneal Neuropathy Before Foot Drop. 61
32459730 2020
Inclusion Body Myositis. Genetics, Biomarkers and Muscle Biopsy. 61
32364415 2020
Herpes zoster infection-induced common peroneal nerve paresis resulting in foot drop in a patient with eosinophilic fasciitis: a case report. 61
32075466 2020
Expanding the clinical and neuroimaging features of NKX6-2-related hereditary spastic ataxia type 8. 61
32004679 2020
Spinal Emergency Surgery During Pregnancy: Contemporary Strategies and Outcome. 61
32305614 2020
Autoimmune polyradiculitis due to combination immunotherapy with ipilimumab and nivolumab for the treatment of metastatic melanoma. 61
31983645 2020
The functional effect of 3D-printing individualized orthosis for patients with peripheral nerve injuries: Three case reports. 61
32311991 2020
Subclinical Peroneal Neuropathy Affects Ambulatory, Community-Dwelling Adults and Is Associated with Falling. 61
32221217 2020
Extensor Tendon Transfers for Treatment of Foot Drop in Charcot-Marie-Tooth Disease: A Biomechanical Evaluation. 61
31941350 2020
Malignant peripheral nerve sheath tumor of the sciatic nerve presenting with leg pain in the setting of lumbar scoliosis and spinal stenosis. 61
31925758 2020
External iliac artery thrombosis following open reduction of acetabular fracture: a case report and literature review. 61
31642955 2020
Soleus nerve transfer to deep peroneal nerve for treatment of foot drop. 61
32336637 2020
Foot drop after percutaneous treatment with radiopaque gelified ethanol (Discogel®). 61
32336588 2020
Immediate Effects of Ankle-Foot Orthosis Using Wire on Static Balance of Patients with Stroke with Foot Drop: A Cross-Over Study. 61
32354201 2020
Adaptive stimulation profiles modulation for foot drop correction using functional electrical stimulation: a proof of concept study. 61
32340970 2020
Shrinking lakes, air pollution, and human health: Evidence from California's Salton Sea. 61
31931219 2020
Minimally versus conventional-invasive transforaminal lumbar interbody fusion in patients with failed back surgery syndrome. 61
32319074 2020
The trouble with footwear following stroke: a qualitative study of the views and experience of people with stroke. 61
30621463 2020
The impact of ankle-foot-orthosis (AFO) use on the compensatory stepping response required to avoid a fall during trip-like perturbations in young adults: Implications for AFO prescription and design. 61
32197789 2020
Advances in neuroprosthetic management of foot drop: a review. 61
32213196 2020
Neurological Complication After Laparoscopic Sleeve Gastrectomy: Foot Drop. 61
31741213 2020
Foot drop following primary total hip arthroplasty. 61
30912466 2020
Clinical Reasoning: A case of bilateral foot drop in a 74-year-old man. 61
32041727 2020
Transfer of the peroneal component of the sciatic nerve in total brachial plexus lesion: An anatomical feasibility study. 61
32201119 2020
The effect of vascular approach surgeons on perioperative complications in lateral transpsoas lumbar interbody fusions. 61
31669613 2020
[Hereditary Polyneuropathies]. 61
32232809 2020
Primary Total Hip Arthroplasty in Patients 20 Years Old and Younger. 61
31977814 2020
[Surgical decompression of the peroneal nerve at the level of the fibular head]. 61
32100068 2020
Permanent damage of the sciatic nerve in an 8-year-old girl with newly diagnosed type 1 diabetes. 61
30739577 2020
[Design and application of prevention baffle for foot drop in suspension bed]. 61
32114731 2020
Direct muscle neurotization with long acellular nerve allograft: A case report. 61
31328294 2020
An exploration of the experiences and utility of functional electrical stimulation for foot drop in people with multiple sclerosis. 61
30299176 2020
Utility of motor evoked potentials to diagnose and reduce lower extremity motor nerve root injuries during 4,386 extradural posterior lumbosacral spine procedures. 61
31479780 2020
Acute bilateral foot drop due to lumbar disc herniation treated by bilateral interlaminar approach: case report and literature review. 61
31955631 2020
A Case of Lower Extremity Weakness with Foot Drop Following Intramedullary Nailing of a Pathologic Femoral Fracture. 61
31949995 2020
Intraneural Peroneal Ganglion Cyst Excision in a Pediatric Patient: A Case Report. 61
32044771 2020

Variations for Foot Drop

Expression for Foot Drop

Search GEO for disease gene expression data for Foot Drop.

Pathways for Foot Drop

Pathways related to Foot Drop according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 PMP22 MPZ
2 10.66 TTN NEB ACTA1

GO Terms for Foot Drop

Cellular components related to Foot Drop according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 9.16 TTN NEB
2 striated muscle thin filament GO:0005865 8.96 TTN ACTA1
3 sarcomere GO:0030017 8.8 TTN NEB ACTA1

Biological processes related to Foot Drop according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle contraction GO:0006936 9.32 TTN ACTA1
2 muscle organ development GO:0007517 9.26 NEB FHL1
3 myelination GO:0042552 9.16 PMP22 MPZ
4 skeletal muscle thin filament assembly GO:0030240 8.96 TTN ACTA1
5 muscle filament sliding GO:0030049 8.8 TTN NEB ACTA1

Molecular functions related to Foot Drop according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of muscle GO:0008307 8.62 TTN NEB

Sources for Foot Drop

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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