Foot Drop disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: FTD001 MIFTS: 33	Foot Drop Categories: Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

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Aliases & Classifications for Foot Drop

MalaCards integrated aliases for Foot Drop:

Name: Foot Drop ⁵³

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

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Summaries for Foot Drop

NINDS : ⁵³ Foot drop describes the inability to raise the front part of the foot due to weakness or paralysis of the muscles that lift the foot. As a result, individuals with foot drop scuff their toes along the ground or bend their knees to lift their foot higher than usual to avoid the scuffing, which causes what is called a “steppage” gait. Foot drop can be unilateral (affecting one foot) or bilateral (affecting both feet). Foot drop is a symptom of an underlying problem and is either temporary or permanent, depending on the cause. Causes include: neurodegenerative disorders of the brain that cause muscular problems, such as multiple sclerosis, stroke, and cerebral palsy; motor neuron disorders such as polio, some forms of spinal muscular atrophy and amyotrophic lateral sclerosis (commonly known as Lou Gehrig’s disease); injury to the nerve roots, such as in spinal stenosis; peripheral nerve disorders such as Charcot-Marie-Tooth disease or acquired peripheral neuropathy; local compression or damage to the peroneal nerve as it passes across the fibular bone below the knee; and muscle disorders, such as muscular dystrophy or myositis.

MalaCards based summary : Foot Drop is related to neuropathy, hereditary, with liability to pressure palsies and childhood-onset nemaline myopathy. An important gene associated with Foot Drop is ACTA1 (Actin Alpha 1, Skeletal Muscle), and among its related pathways/superpathways are Neural Crest Differentiation and Striated Muscle Contraction. The drugs Bupivacaine and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and b cells, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : ⁷⁴ Foot drop is a gait abnormality in which the dropping of the forefoot happens due to weakness,... more...

Sources

Related Diseases for Foot Drop

Diseases related to Foot Drop via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)

#	Related Disease	Score	Top Affiliating Genes
1	neuropathy, hereditary, with liability to pressure palsies	32.4	PMP22 MPZ
2	childhood-onset nemaline myopathy	31.6	NEB ACTA1
3	tibial muscular dystrophy	31.4	TTN NEB
4	charcot-marie-tooth disease and deafness	30.9	PMP22 MPZ
5	hereditary neuropathies	30.0	PMP22 MPZ
6	mononeuropathy	29.9	PMP22 MPZ
7	neuritis	29.8	PMP22 MPZ
8	peripheral nervous system disease	29.7	TTN PMP22 MPZ
9	nemaline myopathy	29.6	NEB ACTA1
10	guillain-barre syndrome	29.5	PMP22 MPZ
11	neurilemmoma	29.4	PMP22 MPZ
12	sensory peripheral neuropathy	29.2	PMP22 MPZ
13	neuromuscular disease	29.0	TTN PMP22 MPZ ACTA1
14	muscular dystrophy	29.0	TTN NEB FHL1 ACTA1
15	myopathy, congenital	29.0	TTN NEB ACTA1
16	myopathy	28.7	TTN NEB FHL1 ACTA1
17	peroneal nerve paralysis	11.6
18	charcot-marie-tooth disease	11.6
19	cauda equina syndrome	11.5
20	facioscapulohumeral muscular dystrophy 1	11.5
21	myopathy, myofibrillar, 9, with early respiratory failure	11.5
22	scapuloperoneal myopathy, x-linked dominant	11.2
23	hereditary motor and sensory neuropathy v	11.2
24	welander distal myopathy	11.2
25	spinal muscular atrophy, distal, autosomal recessive, 2	11.2
26	myopathy, scapulohumeroperoneal	11.2
27	dysferlinopathy	11.2
28	distal myopathy with vocal cord weakness	11.2
29	multifocal motor neuropathy	11.2
30	neuropathy	10.5
31	hansen's disease	10.5
32	leprosy 3	10.5
33	radiculopathy	10.5
34	spinal stenosis	10.3
35	tooth disease	10.3
36	polyneuropathy	10.3
37	peroneal neuropathy	10.3
38	cerebral palsy	10.2
39	stroke, ischemic	10.2
40	hemiplegia	10.2
41	cerebrovascular disease	10.2
42	compartment syndrome	10.2
43	back pain	10.2
44	lymphoma	10.2
45	herpes zoster	10.2
46	vasculitis	10.2
47	aneurysm	10.2
48	spasticity	10.2
49	scapuloperoneal myopathy	10.1	FHL1 ACTA1
50	syringomyelia, noncommunicating isolated	10.1

Graphical network of the top 20 diseases related to Foot Drop:

Sources

Symptoms & Phenotypes for Foot Drop

MGI Mouse Phenotypes related to Foot Drop:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.73	ACTA1 FHL1 MPZ NEB PMP22 TTN
2	growth/size/body region	MP:0005378	9.63	ACTA1 FHL1 MPZ NEB PMP22 TTN
3	homeostasis/metabolism	MP:0005376	9.43	ACTA1 FHL1 MPZ NEB PMP22 TTN
4	muscle	MP:0005369	9.02	ACTA1 FHL1 NEB PMP22 TTN

Sources

Drugs & Therapeutics for Foot Drop

Drugs for Foot Drop (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bupivacaine

Approved, Investigational

Phase 3

38396-39-3, 2180-92-9

2474

Synonyms:

( inverted exclamation markA)-bupivacaine

(+-)-Bupivacaine

(±)-bupivacaine

(1)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

(RS)-bupivacaine

15233-43-9

1-Butyl-2',6'-pipecoloxylidide

1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide

1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

2180-92-9

38396-39-3

AB00053674

Abbott brand OF bupivacaine hydrochloride

AC1L1DRE

AC1Q5LX4

AC-2096

AH 250

AKOS001637202

Anekain

Anhydrous, bupivacaine

AR-1A0242

Astra brand OF bupivacaine hydrochloride

AstraZeneca brand OF bupivacaine hydrochloride

Aventis brand OF bupivacaine hydrochloride

Bio-0886

Bloqueina

BPBio1_000298

Braun brand OF bupivacaine hydrochloride

Braun, bupivacaina

BRD-A01636364-003-05-2

BSPBio_000270

BSPBio_002607

Bucaine

Bucaine (TN)

Bupivacain janapharm

Bupivacain RPR

Bupivacaina

Bupivacaina [INN-Spanish]

Bupivacaina braun

bupivacaine

Bupivacaine

Bupivacaine (INN)

Bupivacaine [INN:BAN]

Bupivacaine anhydrous

Bupivacaine carbonate

Bupivacaine Carbonate

Bupivacaine HCL

Bupivacaine HCL kit

Bupivacaine HCL KIT

Bupivacaine hydrochloride

Bupivacaine monohydrochloride, monohydrate

Bupivacaine Monohydrochloride, Monohydrate

Bupivacain-RPR

Bupivacainum

Bupivacainum [INN-Latin]

Bupivan

Buvacaina

C07529

C18H28N2O

Carbonate, bupivacaine

Carbostesin

cBupivacaine

CBupivacaine

CHEBI:3215

CHEMBL1098

CID2474

D07552

DB00297

DepoBupivacaine

DivK1c_000758

dl-1-Butyl-2',6'-pipecoloxylidide

DL-Bupivacaine

Dolanaest

DUR-843

EINECS 218-553-3

EINECS 253-911-2

HMS2090F12

Hydrochloride, bupivacaine

IDI1_000758

Inibsa brand OF bupivacaine hydrochloride

Janapharm, bupivacain

Jenapharm brand OF bupivacaine hydrochloride

KBio1_000758

KBio2_002004

KBio2_004572

KBio2_007140

KBio3_001827

KBioGR_001516

KBioSS_002004

KST-1A4609

L000695

LAC-43

LS-109841

LS-2222

Marcain

Marcaina

Marcaine

Marcaine HCL

Marcaine Spinal

MLS001361336

MolPort-004-955-820

NCGC00178579-01

NCGC00178579-02

NINDS_000758

NSC119660

Pisa brand OF bupivacaine hydrochloride

Prestwick0_000305

Prestwick1_000305

Prestwick2_000305

Prestwick3_000305

racemic bupivacaine

Sensorcaine

Sensorcaine-MPF

Sensorcaine-MPF Spinal

SMR000058218

SPBio_001558

SPBio_002489

Spectrum_001524

Spectrum2_001589

Spectrum3_000974

Spectrum4_001098

Spectrum5_001483

Strathmann brand OF bupivacaine hydrochloride

Svedocain sin vasoconstr

Transdur-Bupivacaine

UNII-Y8335394RO

Win 11318

Win 11318 HCl

Anesthetics, Local

Phase 3

Anesthetics

Phase 3

Central Nervous System Depressants

Phase 3

Azacitidine

Approved, Investigational

Phase 2

320-67-2

9444

Synonyms:

2-(beta-D-Ribofuranosyl)-4-amino-1,3,5-triazin-2-one

320-67-2

4-Amino-1-(beta-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one

4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triaz

4-amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3,5-triazin-2-one

4-amino-1-b-D-Ribofuranosyl-S-triazin-2(1H)-one

4-Amino-1-beta-D-ribofuranosyl-1,3,5-traizin-2(1H)-one

4-Amino-1-beta-d-ribofuranosyl-1,3,5-triazin-2(1H)-one

4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazine-2(1H)-one

4-amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one

4-amino-1-beta-D-Ribofuranosyl-S-triazin-2(1H)-one

4-Amino-1-beta-D-ribofuranosyl-s-triazin-2(1H)-one

4-amino-1-beta-L-ribofuranosyl-1,3,5-triazin-2(1H)-one

4-amino-1-β-D-ribofuranosyl-S-triazin-2(1H)-one

5 Azacytidine

5 AZC

5-AC

5AzaC

5-AZAC

5-azacitidine

5-aza-CR

5-azacytidine

5-azacytidine, Mylosar, Ladakamycin, Vidaza, Azacitidine

5-AZCR

A 2385

A1287_SIGMA

A2385_SIGMA

AC1L1T1Y

Antibiotic U 18496

Azacitidina

Azacitidina [INN-Spanish]

Azacitidine

Azacitidine (JAN/USAN/INN)

Azacitidine [USAN:INN]

Azacitidinum

Azacitidinum [INN-Latin]

Azacytidine

BCBcMAP01_000083

BRN 0620461

BSPBio_003157

C11262

CCRIS 60

CHEBI:2038

CHEMBL1489

CID9444

cMAP_000082

CPD000857239

D001374

D03021

DB00928

DivK1c_000125

EINECS 206-280-2

EU-0100035

FT-0081170

HMS1921J22

HMS2092D08

HMS500G07

HSDB 6879

IDI1_000125

InChI=1/C8H12N4O5/c9-7-10-2-12(8(16)11-7)6-5(15)4(14)3(1-13)17-6/h2-6,13-15H,1H2,(H2,9,11,16)/t3-,4-,5-,6-/m1/s1

Jsp005945

KBio1_000125

KBio2_001742

KBio2_002556

KBio2_004310

KBio2_005124

KBio2_006878

KBio2_007692

KBio3_002657

KBio3_003034

KBioGR_001444

KBioGR_002556

KBioSS_001742

KBioSS_002565

Ladakamycin

Lopac0_000035

LS-1189

MLS001333121

MLS001333122

MLS002153249

MolMap_000062

mylo sar

Mylosar

NCGC00090851-01

NCGC00090851-02

NCGC00090851-03

NCGC00090851-04

NCGC00090851-08

NCGC00178234-01

NCI-C01569

NINDS_000125

NS-17

NSC 102816

NSC102816

NSC-102816

Pharmion brand OF azacitidine

Pharmion Brand of Azacitidine

pyrimidine antimetabolite: inhibits nucleic acid replication

S1782_Selleck

SAM002264595

SMR000857239

SPBio_000892

Spectrum_001262

SPECTRUM1502111

Spectrum2_000786

Spectrum3_001509

Spectrum4_000922

Spectrum5_001166

ST056940

s-Triazin-2(1H)-one, 4-amino-1-beta-D-ribofuranosyl- (8CI)

TL80073599

U 18496

U-18496

UNII-M801H13NRU

Vidaza

Vidaza (TN)

wr 183027

WR-183027

ZINC03861768

Mepivacaine

Approved, Vet_approved

96-88-8

4062

Synonyms:

(+-)-1-Methyl-2',6'-pipecoloxylidide

1722-62-9 (mono-hydrochloride)

1-methyl-2',6'-pipecoloxylidide

1-Methyl-2',6'-pipecoloxylidide

1-METHYL-2',6'-PIPECOLOXYLIDIDE

22801-44-1

34811-66-0

3m Brand OF mepivacaine hydrochloride

5-22-01-00223 (Beilstein Handbook Reference)

96-88-8

Abbott brand OF mepivacaine hydrochloride

AC-15503

AC1L1HBV

Arestocaine HCL

Astra brand OF mepivacaine hydrochloride

AstraZeneca brand OF mepivacaine hydrochloride

Aventis brand OF mepivacaine hydrochloride

Braun brand OF mepivicaine hydrochloride

Braun, mepivacaina

BRD-A03216249-003-02-9

BRN 0211230

BSPBio_003297

C07528

Carbocain

Carbocaine

Carbocaïne

Carboplyin Dental

Carboplyin Dental (TN)

CHEBI:6759

CHEMBL1087

CID4062

Clarben brand OF mepivacaine hydrochloride

Curasan brand OF mepivacaine hydrochloride

D(-)-Mepivacaine

D08181

DB00961

Dentsply brand OF mepivacaine hydrochloride

DivK1c_006970

DL-Mepivacaine

D-mepivacaine

EINECS 202-543-0

Hexal brand OF mepivacaine hydrochloride

Hydrochloride, mepivacaine

I01-1864

Inibsa brand OF mepivacaine hydrochloride

Isocaine

Isocaine HCL

Isogaine

KBio1_001914

KBio2_001960

KBio2_004528

KBio2_007096

KBio3_002517

KBioGR_001092

KBioSS_001960

LS-109848

LS-109849

Meaverin

Mecain

Mepihexal

Mepivacain injektopas

Mepivacaina

Mepivacaina [INN-Spanish]

Mepivacaina braun

mepivacaine

Mepivacaine

Mepivacaine (INN)

Mepivacaine [INN:BAN]

Mepivacaine HCL

mepivacaine hydrochloride

Mepivacaine hydrochloride

Mepivacaine monohydrochloride

Mepivacain-injektopas

Mepivacainum

Mepivacainum [INN-Latin]

Mepivastesin

Mepivicaine

MolPort-005-935-383

Monohydrochloride, mepivacaine

N-(2,6-Dimethylphenyl)-1-methyl-2-piperidinecarboxamide

N-(2,6-Dimethylphenyl)-1-methylpiperidine-2-carboxamide

NCGC00089774-02

N-Methyl-2-pipecolic acid, 2,6-dimethylanilide

N-Methyl-2-pipecolic acid, 2,6-xylidide

N-Methylhexahydro-2-picolinic acid, 2,6-dimethylanilide

Novocol brand OF mepivacaine hydrochloride

Pascoe brand OF mepivacaine hydrochloride

Polocaine

Polocaine-Mpf

Polocaine-MPF

Sanofi brand OF mepivacaine hydrochloride

Scandicain

Scandicaine

Scandicane

Scandinibsa

Scandonest

Scandonest Plain

SPBio_001811

SpecPlus_000874

Spectrum_001480

Spectrum2_001656

Spectrum3_001629

Spectrum4_000596

Spectrum5_001354

S-Ropivacaine mesylate

S-Ropivacaine Mesylate

UNII-B6E06QE59J

Levobupivacaine

Approved, Investigational

27262-47-1

92253

Synonyms:

(-)-bupivacaine

(-)-Bupivacaine

(2S)-1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide

(S)-1-butyl-2',6'-pipecoloxylidide

(S)-1-Butyl-2',6'-pipecoloxylidide

(S)-bupivacaine

(S)-Bupivacaine

27262-47-1

27262-48-2

AC1L3NQM

BIDD:GT0471

C07887

C18H28N2O

CAS-18010-40-7

CHEBI:6149

Chirocaine

CID92253

D08116

DB01002

L-(-)-1-Butyl-2',6'-pipecoloxylidide

L-(-)-bupivacaine

L-(−)-bupivacaine

L(-)-Bupivacaine

L-(-)-Bupivacaine

Levobupivacaína

Levobupivacaine

Levobupivacaine (INN)

Levobupivacaine [INN:BAN]

Levobupivacaine hydrochloride

LS-109843

LS-187025

LS-187789

MolPort-004-959-713

NCGC00016733-01

NCGC00159482-02

Novabupi

Novabupi (TN)

Ropivacaine

Approved

Early Phase 1

84057-95-4

71273 175805

Synonyms:

(-)-1-Propyl-2',6'-dimethyl-2-piperidylcarboxyanilide

(-)-1-Propyl-2',6'-pipecoloxylidide

(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide

(2S)-N-(2,6-dimethylphenyl)-1-propylpiperidine-2-carboxamide hydrochloride

(S)-(−)-1-propyl-2',6'-pipecoloxylidide

(S)-(-)-1-Propyl-2',6'-pipecoloxylidide

(S)-ropivacaine

1-Propyl-2',6'-pipecoloxylidide

84057-95-4

98717-15-8

AC1L41QM

AC1L41QN

BIDD:GT0203

C07532

C17H26N2O.HCl

CHEBI:8890

CHEMBL1077896

CID175804

CID175805

CPD000469137

D08490

I14-176

LEA 103

LEA-103

L-N-N-Propylpipecolate-2,6-xylidide

L-N-n-propylpipecolic acid-2,6-xylidide

L-N-N-Propylpipecolic acid-2,6-xylidide

LS-113954

MLS001401363

MolPort-003-983-292

Naropeine

Naropin

Naropin (TN)

NCGC00164597-01

Ropivacaina

Ropivacaina [INN-Spanish]

Ropivacaina [Spanish]

Ropivacaine

Ropivacaine [INN]

ROPIVACAINE HCl

Ropivacaine hydrochloride

Ropivacaine monohydrochloride

ropivacaine monohydrochloride,

ropivacaine monohydrochloride, (S)-isomer

Ropivacaine monohydrochloride, (S)-isomer

Ropivacainum

Ropivacainum [INN-Latin]

SAM001246524

SMR000469137

S-Ropivacaine

ST51051452

Complement System Proteins

Interventional clinical trials:

(show all 42)

#	Name	Status	NCT ID	Phase	Drugs
1	Effects of Functional Electrical Stimulation on Gait in Children With Hemiplegic and Diplegic Cerebral Palsy	Unknown status	NCT02462018	Phase 4
2	Evaluation of the Safety and Performance of the NESS L300 Plus System	Completed	NCT01237860	Phase 3
3	Comparative Feasibility and Efficacy of a Five Compartment Technique Using 0.25% Bupivacaine vs a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka; a Single Blinded Randomized Controlled Study	Terminated	NCT03303794	Phase 3	Exparel;0.25% bupivacaine
4	Effect of Robot-assisted Training on Foot Drop in Multiple Sclerosis	Completed	NCT00872053	Phase 1, Phase 2
5	An Open-Label Phase 2 Study of ManNAc in Subjects With GNE Myopathy	Completed	NCT02346461	Phase 2	ManNAc;ManNAc
6	Robot-assisted Ankle Rehabilitation for Multiple Sclerosis (Anklebot)	Terminated	NCT00765544	Phase 1, Phase 2
7	Pilot Feasibility Study of the Neurostep™ System in Subjects With Gait Disorder Secondary to CNS Lesion.	Completed	NCT00860210	Phase 1
8	Prospective Randomized Controlled Trial Comparing Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer.	Unknown status	NCT01751503
9	Evaluation of Usability and Human Factors in the Novus System	Unknown status	NCT02738242
10	Pairing Functional Electrical Stimulation (FES) and Volitional Effort Training Promotes Neuroplasticity and Motor Gain	Unknown status	NCT02797886
11	Functional Electrical Stimulation to Treat Foot Drop in People With Multiple Sclerosis	Completed	NCT02123537
12	Targeted Lower Extremity Joint Training Effects on MS Gait Abnormalities	Completed	NCT00906737
13	Functional Electrical Stimulation for People With Multiple Sclerosis Who Experience Foot Drop:Feasibility of Instrumented Gait Analysis in Clinical Practice.	Completed	NCT01914016
14	Adaptive Ankle Robot Control System to Reduce Foot-drop in Chronic Stroke	Completed	NCT02483676
15	Randomized Trial of the Innovative Neurotronics WalkAide Compared to Conventional Ankle-Foot Orthosis (AFO) in Stroke Patients (INSTRIDE)	Completed	NCT01087957
16	Identification of Responders to the FES Interventions in Stroke Population	Completed	NCT01952613
17	Functional Electrical Stimulation for Footdrop in Hemiparesis	Completed	NCT00148343
18	A Pilot Study to Assess the Effects of Using FES or AFO as an Assistive Mobility for Period of 12 Weeks for People With Multiple Sclerosis With Foot Drop	Completed	NCT01977287
19	Parameter Changes in Functional Electrical Stimulation	Completed	NCT03300986
20	A Three-Arm, Randomized Crossover Study Comparing the Innovative Neurotronics WalkAide™ System to Ankle-Foot Orthosis [AFO]	Completed	NCT00216320
21	Implanted Functional Electrical Stimulation of the Levators of the Ankle Versus Orthosis in the Treatment of Chronic Foot Neurological STEPPAGE-gait by Central Attack	Completed	NCT01415700
22	Functional Ambulation: Standard Treatment vs. Electronic Stimulation Therapy (FASTEST)Trial in Chronic Post-Stroke Subjects With Foot Drop	Completed	NCT01138995
23	Clinical Effects of Peroneal Nerve Functional Electrical Stimulation (WalkAide[R]) for the Lower Extremities in Chronic Stroke Patients With Hemiplegia: A Multicenter, Prospective, Randomized Controlled Trial	Completed	NCT02897752
24	Clinical Study to Evaluate the Implantation of the ActiGait Drop Foot Stimulator System	Completed	NCT01116466
25	Approach to Continuous Sciatic Nerve Block for Orthopedic Procedures in Day Surgery With Two Different Techniques	Completed	NCT02029404
26	The Evaluation of Dual Channel vs Single Channel FES for Dropfoot	Completed	NCT02494323
27	Wearable Interactive Lower-limb Exoskeleton Robotic Device for Gait Training of Post-stroke Patients on Different Walking Conditions	Recruiting	NCT03184259
28	Effects of Two Different Types of Ankle Foot Orthoses on Gait Outcomes in Patients With Subacute Stroke.	Recruiting	NCT02693834
29	A Rigid Body Database on Human Movement	Recruiting	NCT00001252
30	Association Between the Transcranial Direct Current Stimulation (tDCS) and Foot Drop Stimulation (FDS) for Gait Rehabilitation After Stroke - A Randomized Clinical Trial	Active, not recruiting	NCT04077814
31	The Therapeutic Effects of Peroneal Nerve Functional Electrical Stimulation for Lower Extremity in Patients With Sub-acute Post-stroke Hemiplegia A Randomized Controlled Study	Active, not recruiting	NCT02898168
32	Multi-pad Functional Electrical Stimulation for Droop Foot Treatment	Enrolling by invitation	NCT02729636
33	Walking Ankle Robot for Foot Drop in Aging and Disabled Populations: A Demonstration Project	Not yet recruiting	NCT03556709
34	Seated Ankle Robot for Foot Drop in Aging and Disabled Populations: A Demonstration Project	Not yet recruiting	NCT03530592
35	The Orthotic Effect of Functional Electrical Stimulation to Treat Foot Drop in People With MS Under Walking Conditions Simulating Those in Daily Life	Not yet recruiting	NCT03410498
36	TREAT Foot Drop After Stroke With Ankle Robot	Not yet recruiting	NCT04137809
37	Do Patients Who Receive the IPACK and Adductor Canal Catheter Have Better Outcomes Than Patients Receiving the Adductor Canal Catheter Alone for Total Knee Replacements?	Not yet recruiting	NCT03774966	Early Phase 1
38	A Wearable for Post-stroke Rehabilitative Multi-muscle Stimulation Inspired by the Natural Organization of Neuromuscular Control	Not yet recruiting	NCT04154514
39	Use Of Autologous Stem Cell Use In Neurological Non-neoplastic Disorders And Disease	Not yet recruiting	NCT03297177
40	The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute Lymphoblastic Leukemia and Foot Drop	Terminated	NCT01001390
41	A Prospective, Randomized Study Comparing Continuous Femoral and Tibial Nerve Blocks vs. Continuous Femoral and Single Shot Sciatic Nerve Block in Total Knee Arthroplasties.	Terminated	NCT01680692	Early Phase 1	Ropivicaine
42	Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty	Withdrawn	NCT02856958

Search NIH Clinical Center for Foot Drop

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Genetic Tests for Foot Drop

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Anatomical Context for Foot Drop

MalaCards organs/tissues related to Foot Drop:

⁴⁰

Bone, Brain, B Cells, Spinal Cord, Liver, Testes, T Cells

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Publications for Foot Drop

Articles related to Foot Drop:

(show top 50) (show all 1182)

#	Title	Authors	PMID	Year
1	Permanent damage of the sciatic nerve in an 8-year-old girl with newly diagnosed type 1 diabetes. ⁶¹	Giza S...Galli-Tsinopoulou A	30739577	2020
2	Utility of motor evoked potentials to diagnose and reduce lower extremity motor nerve root injuries during 4,386 extradural posterior lumbosacral spine procedures. ⁶¹	Wilent WB...Sestokas AK	31479780	2020
3	Expanding the clinical and neuroimaging features of NKX6-2-related hereditary spastic ataxia type 8. ⁶¹	Bereshneh AH...Tavasoli AR	32004679	2020
4	Rare case of bilateral wrist and foot drop from SLE-related vasculitic polyneuropathy. ⁶¹	Sodavarapu S...Hoffman J	31948979	2020
5	A Case Study of Puerperal Group A Streptococcal Infection Complicated by Toxic Shock Syndrome. ⁶¹	Olp RJ...Schmiedecke SS	31993244	2020
6	Malignant peripheral nerve sheath tumor of the sciatic nerve presenting with leg pain in the setting of lumbar scoliosis and spinal stenosis. ⁶¹	Suratwala SJ...Leone V	31925758	2020
7	Post-operative analgesia techniques after total knee arthroplasty: A narrative review. ⁶¹	Krishna Prasad GV	31998025	2020
8	Extensor Tendon Transfers for Treatment of Foot Drop in Charcot-Marie-Tooth Disease: A Biomechanical Evaluation. ⁶¹	Pfeffer GB...Metzger M	31941350	2020
9	Can Repeated Ponseti Management for Relapsed Clubfeet Produce the Outcome Comparable With the Case Without Relapse? A Clinical Study in Term of Gait Analysis. ⁶¹	Liu YB...Zhao DH	31815859	2020
10	Lyme Neuroborreliosis in a Patient with Breast Cancer: MRI and PET/CT Findings. ⁶¹	Orbak M...Mens H	31936608	2020
11	Autoimmune polyradiculitis due to combination immunotherapy with ipilimumab and nivolumab for the treatment of metastatic melanoma. ⁶¹	Lasocki A...Smith K	31983645	2020
12	Sub-Clinical Peroneal Neuropathy affects Ambulatory, Community Dwelling Adults and is Associated with Falling. ⁶¹	Poppler LH...Mackinnon SE	31929455	2020
13	[Tendon transfer as a treatment modality of peroneal nerve palsy]. ⁶¹	Olsen MH...Andersen GR	31928619	2020
14	Foot Drop after Ilio-Caval Vein Stenting: Radicular syndrome from stent misplacement in the spinal canal. ⁶¹	Zaldivar-Jolissaint JF...Morard M	31954898	2020
15	A Case of Lower Extremity Weakness with Foot Drop Following Intramedullary Nailing of a Pathologic Femoral Fracture. ⁶¹	Gusho CA	31949995	2020
16	Acute bilateral foot drop due to lumbar disc herniation treated by bilateral interlaminar approach: case report and literature review. ⁶¹	Marchesini N...Teli M	31955631	2020
17	Shrinking lakes, air pollution, and human health: Evidence from California's Salton Sea. ⁶¹	Jones BA...Fleck J	31931219	2020
18	Primary Total Hip Arthroplasty in Patients 20 Years Old and Younger. ⁶¹	Pallante GD...Trousdale RT	31977814	2020
19	Modified bridle tendon transfer procedure following a complete musculature loss of the anterior leg compartment: Case report and literature review. ⁶¹	Medina A	31872026	2019
20	When size does not matter: a rare case of popliteal artery aneurysm presenting with foot drop and its endovascular management. ⁶¹	Yahng JJ...Ying L	31908761	2019
21	Acute Superficial Peroneal Nerve Entrapment Mimicking Compartment Syndrome: A Case Report. ⁶¹	Haddad SF...Czajka C	31789667	2019
22	Pseudoaneurysm of the Popliteal Artery Leading to Foot Drop After Arthroscopic Anterior Cruciate Ligament Reconstruction: A Rare Complication: A Case Report. ⁶¹	Joshi A...Basukala B	31609751	2019
23	Thrombotic microangiopathy involving kidney allograft and peripheral nerves. ⁶¹	Naddaf E...Amer H	31816173	2019
24	Case of atypical cutaneous Mycobacteriumchelonae infection in patient of systemic lupus erythematosus after cyclophosphamide therapy. ⁶¹	Rasool S...De Lord D	31818891	2019
25	GNE myopathy - A cross-sectional study on spatio-temporal gait characteristics. ⁶¹	Gomez G...Vengalil S	31787465	2019
26	A rare case of parasagittal meningioma causing isolated foot drop: case report and review of the literature. ⁶¹	Bilic H...Bilic E	31786742	2019
27	Guillain-Barre syndrome observed with adoptive transfer of lymphocytes genetically engineered with an NY-ESO-1 reactive T-cell receptor. ⁶¹	Joseph J...Conley AP	31703609	2019
28	Clinical features of Pompe disease with motor neuronopathy. ⁶¹	Tsai LK...Chien YH	31706699	2019
29	Asymmetric Three-Column Osteotomy for Coronal Malalignment in Adult Patients with Prior Thoracic Fusion for Adolescent Idiopathic Scoliosis: Three-Year Follow-up. ⁶¹	Raman T...Kebaish KM	31382065	2019
30	Compressive peroneal neuropathy by an intraneural ganglion cyst combined with L5 radiculopathy: A case report. ⁶¹	Park SH...Jo GY	31689879	2019
31	Eribulin-Associated Foot Drop. ⁶¹	Blair TF...Muzaffar M	30570505	2019
32	Neurological Complication After Laparoscopic Sleeve Gastrectomy: Foot Drop. ⁶¹	Sen O...Turkcapar A	31741213	2019
33	Ipsilateral foot drop after aortobifemoral bypass. ⁶¹	Raut MS...Gupta P	31621683	2019
34	Test-retest reliability and minimal detectable change of ankle kinematics and spatiotemporal parameters in MS population. ⁶¹	Andreopoulou G...van der Linden ML	31561120	2019
35	The effect of vascular approach surgeons on perioperative complications in lateral transpsoas lumbar interbody fusions. ⁶¹	Manning J...Buckland AJ	31669613	2019
36	External iliac artery thrombosis following open reduction of acetabular fracture: a case report and literature review. ⁶¹	Yamamoto N...Ozaki T	31642955	2019
37	Pediatric ganglioglioma of the brainstem and cervicomedullary junction: a retrospective cohort study. ⁶¹	Oushy S...Daniels DJ	31585412	2019
38	Case report of a partially thrombosed ACoA aneurysm presenting with bilateral foot drop. ⁶¹	Sweid A...Jabbour P	31437667	2019
39	The Inherited Neuromuscular Disorder GNE Myopathy: Research to Patient Care. ⁶¹	Awasthi K...Bhattacharya S	31744945	2019
40	Glial Fibrillary Acidic Protein (GFAP) Autoimmunity in the Setting of Seropositive Rheumatoid Arthritis Treated With Etanercept. ⁶¹	Smith KM...Kantarci OH	31478999	2019
41	Acute sensorimotor polyneuropathy as an early sign of polyarteritis nodosa. A case report. ⁶¹	Kazakov VM...Perfilyev SV	31788663	2019
42	Facet joint cyst haematoma: a rare cause of cauda equina syndrome. ⁶¹	Kumaria A...Bateman AH	31507217	2019
43	Neuromuscular electrical stimulation-promoted plasticity of the human brain. ⁶¹	Carson RG...Buick AR	31495924	2019
44	Label Self-Advised Support Vector Machine (LSA-SVM)-Automated Classification of Foot Drop Rehabilitation Case Study. ⁶¹	Adil Abboud S...Al-Jumaily A	31569694	2019
45	[Surgical Results of Lumbar Degenerative Disease with Foot Drop]. ⁶¹	Takaishi Y...Arai A	31477628	2019
46	Direct muscle neurotization with long acellular nerve allograft: A case report. ⁶¹	Tuffaha SH...Moran SL	31328294	2019
47	Long-term use of implanted peroneal functional electrical stimulation for stroke-affected gait: the effects on muscle and motor nerve. ⁶¹	Berenpas F...van Alfen N	31292003	2019
48	Significant Impact of Implantable Functional Electrical Stimulation on Gait Parameters: A Kinetic Analysis in Foot Drop Patients. ⁶¹	Bucklitsch J...Quick-Weller J	30954755	2019
49	Evaluating the Effect of Functional Electrical Stimulation Used for Foot Drop on Aspects of Health-Related Quality of Life in People with Multiple Sclerosis: A Systematic Review. ⁶¹	Miller Renfrew L...Hunter R	31474810	2019
50	The clinical- and cost-effectiveness of functional electrical stimulation and ankle-foot orthoses for foot drop in Multiple Sclerosis: a multicentre randomized trial. ⁶¹	Renfrew LM...Mattison P	30974955	2019

Sources

Genes for Foot Drop

Genes related to Foot Drop (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	ACTA1	Actin Alpha 1, Skeletal Muscle	Protein Coding	7.87	GeneCards inferred via : Disorders (show sections)
2	FHL1	Four And A Half LIM Domains 1	Protein Coding	7.87	GeneCards inferred via : Disorders (show sections)
3	TTN	Titin	Protein Coding	7.87	GeneCards inferred via : Disorders (show sections)
4	MPZ	Myelin Protein Zero	Protein Coding	6.92	GeneCards inferred via : Publications (show sections)
5	NEB	Nebulin	Protein Coding	6.92	GeneCards inferred via : Publications (show sections)
6	PMP22	Peripheral Myelin Protein 22	Protein Coding	6.92	GeneCards inferred via : Publications (show sections)

Sources

Variations for Foot Drop

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Expression for Foot Drop

Search GEO for disease gene expression data for Foot Drop.

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Pathways for Foot Drop

Pathways related to Foot Drop according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neural Crest Differentiation ¹	10.96	PMP22 MPZ
2	Striated Muscle Contraction ⁶⁵ ¹	10.66	TTN NEB ACTA1

Sources

GO Terms for Foot Drop

Cellular components related to Foot Drop according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Z disc	GO:0030018	9.16	TTN NEB
2	striated muscle thin filament	GO:0005865	8.96	TTN ACTA1
3	sarcomere	GO:0030017	8.8	TTN NEB ACTA1

Biological processes related to Foot Drop according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	muscle contraction	GO:0006936	9.32	TTN ACTA1
2	muscle organ development	GO:0007517	9.26	NEB FHL1
3	myelination	GO:0042552	9.16	PMP22 MPZ
4	skeletal muscle thin filament assembly	GO:0030240	8.96	TTN ACTA1
5	muscle filament sliding	GO:0030049	8.8	TTN NEB ACTA1

Molecular functions related to Foot Drop according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	structural constituent of muscle	GO:0008307	8.62	TTN NEB

Sources

Sources for Foot Drop

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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¹⁰ dbSNP

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²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

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⁴³ MeSH

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⁴⁷ NCBI Bookshelf

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⁵¹ NIH Clinical Center

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⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

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⁶⁰ PharmGKB

⁶¹ PubMed

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⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

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⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia