Aliases & Classifications for Foot Drop

MalaCards integrated aliases for Foot Drop:

Name: Foot Drop 53

Classifications:



Summaries for Foot Drop

NINDS : 53 Foot drop describes the inability to raise the front part of the foot due to weakness or paralysis of the muscles that lift the foot. As a result, individuals with foot drop scuff their toes along the ground or bend their knees to lift their foot higher than usual to avoid the scuffing, which causes what is called a “steppage” gait. Foot drop can be unilateral (affecting one foot) or bilateral (affecting both feet). Foot drop is a symptom of an underlying problem and is either temporary or permanent, depending on the cause. Causes include: neurodegenerative disorders of the brain that cause muscular problems, such as multiple sclerosis, stroke, and cerebral palsy; motor neuron disorders such as polio, some forms of spinal muscular atrophy and amyotrophic lateral sclerosis (commonly known as Lou Gehrig’s disease); injury to the nerve roots, such as in spinal stenosis; peripheral nerve disorders such as Charcot-Marie-Tooth disease or acquired peripheral neuropathy; local compression or damage to the peroneal nerve as it passes across the fibular bone below the knee; and muscle disorders, such as muscular dystrophy or myositis.

MalaCards based summary : Foot Drop is related to neuropathy, hereditary, with liability to pressure palsies and childhood-onset nemaline myopathy. An important gene associated with Foot Drop is ACTA1 (Actin Alpha 1, Skeletal Muscle), and among its related pathways/superpathways are Neural Crest Differentiation and Striated Muscle Contraction. The drugs Bupivacaine and Anesthetics, Local have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and b cells, and related phenotypes are behavior/neurological and growth/size/body region

Wikipedia : 74 Foot drop is a gait abnormality in which the dropping of the forefoot happens due to weakness,... more...

Related Diseases for Foot Drop

Diseases related to Foot Drop via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 238)
# Related Disease Score Top Affiliating Genes
1 neuropathy, hereditary, with liability to pressure palsies 32.4 PMP22 MPZ
2 childhood-onset nemaline myopathy 31.6 NEB ACTA1
3 tibial muscular dystrophy 31.4 TTN NEB
4 charcot-marie-tooth disease and deafness 30.9 PMP22 MPZ
5 hereditary neuropathies 30.0 PMP22 MPZ
6 mononeuropathy 29.9 PMP22 MPZ
7 neuritis 29.8 PMP22 MPZ
8 peripheral nervous system disease 29.7 TTN PMP22 MPZ
9 nemaline myopathy 29.6 NEB ACTA1
10 guillain-barre syndrome 29.5 PMP22 MPZ
11 neurilemmoma 29.4 PMP22 MPZ
12 sensory peripheral neuropathy 29.2 PMP22 MPZ
13 neuromuscular disease 29.0 TTN PMP22 MPZ ACTA1
14 muscular dystrophy 29.0 TTN NEB FHL1 ACTA1
15 myopathy, congenital 29.0 TTN NEB ACTA1
16 myopathy 28.7 TTN NEB FHL1 ACTA1
17 peroneal nerve paralysis 11.6
18 charcot-marie-tooth disease 11.6
19 cauda equina syndrome 11.5
20 facioscapulohumeral muscular dystrophy 1 11.5
21 myopathy, myofibrillar, 9, with early respiratory failure 11.5
22 scapuloperoneal myopathy, x-linked dominant 11.2
23 hereditary motor and sensory neuropathy v 11.2
24 welander distal myopathy 11.2
25 spinal muscular atrophy, distal, autosomal recessive, 2 11.2
26 myopathy, scapulohumeroperoneal 11.2
27 dysferlinopathy 11.2
28 distal myopathy with vocal cord weakness 11.2
29 multifocal motor neuropathy 11.2
30 neuropathy 10.5
31 hansen's disease 10.5
32 leprosy 3 10.5
33 radiculopathy 10.5
34 spinal stenosis 10.3
35 tooth disease 10.3
36 polyneuropathy 10.3
37 peroneal neuropathy 10.3
38 cerebral palsy 10.2
39 stroke, ischemic 10.2
40 hemiplegia 10.2
41 cerebrovascular disease 10.2
42 compartment syndrome 10.2
43 back pain 10.2
44 lymphoma 10.2
45 herpes zoster 10.2
46 vasculitis 10.2
47 aneurysm 10.2
48 spasticity 10.2
49 scapuloperoneal myopathy 10.1 FHL1 ACTA1
50 syringomyelia, noncommunicating isolated 10.1

Graphical network of the top 20 diseases related to Foot Drop:



Diseases related to Foot Drop

Symptoms & Phenotypes for Foot Drop

MGI Mouse Phenotypes related to Foot Drop:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 ACTA1 FHL1 MPZ NEB PMP22 TTN
2 growth/size/body region MP:0005378 9.63 ACTA1 FHL1 MPZ NEB PMP22 TTN
3 homeostasis/metabolism MP:0005376 9.43 ACTA1 FHL1 MPZ NEB PMP22 TTN
4 muscle MP:0005369 9.02 ACTA1 FHL1 NEB PMP22 TTN

Drugs & Therapeutics for Foot Drop

Drugs for Foot Drop (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bupivacaine Approved, Investigational Phase 3 38396-39-3, 2180-92-9 2474
2 Anesthetics, Local Phase 3
3 Anesthetics Phase 3
4 Central Nervous System Depressants Phase 3
5
Azacitidine Approved, Investigational Phase 2 320-67-2 9444
6
Mepivacaine Approved, Vet_approved 96-88-8 4062
7
Levobupivacaine Approved, Investigational 27262-47-1 92253
8
Ropivacaine Approved Early Phase 1 84057-95-4 71273 175805
9 Complement System Proteins

Interventional clinical trials:

(show all 42)
# Name Status NCT ID Phase Drugs
1 Effects of Functional Electrical Stimulation on Gait in Children With Hemiplegic and Diplegic Cerebral Palsy Unknown status NCT02462018 Phase 4
2 Evaluation of the Safety and Performance of the NESS L300 Plus System Completed NCT01237860 Phase 3
3 Comparative Feasibility and Efficacy of a Five Compartment Technique Using 0.25% Bupivacaine vs a Mixture of 0.25% Bupivacaine and 1.3 % Liposomal Bupivacaine in Patients Undergoing Tka; a Single Blinded Randomized Controlled Study Terminated NCT03303794 Phase 3 Exparel;0.25% bupivacaine
4 Effect of Robot-assisted Training on Foot Drop in Multiple Sclerosis Completed NCT00872053 Phase 1, Phase 2
5 An Open-Label Phase 2 Study of ManNAc in Subjects With GNE Myopathy Completed NCT02346461 Phase 2 ManNAc;ManNAc
6 Robot-assisted Ankle Rehabilitation for Multiple Sclerosis (Anklebot) Terminated NCT00765544 Phase 1, Phase 2
7 Pilot Feasibility Study of the Neurostep™ System in Subjects With Gait Disorder Secondary to CNS Lesion. Completed NCT00860210 Phase 1
8 Prospective Randomized Controlled Trial Comparing Extramembranous and Interosseous Technique of Tibialis Posterior Tendon Transfer. Unknown status NCT01751503
9 Evaluation of Usability and Human Factors in the Novus System Unknown status NCT02738242
10 Pairing Functional Electrical Stimulation (FES) and Volitional Effort Training Promotes Neuroplasticity and Motor Gain Unknown status NCT02797886
11 Functional Electrical Stimulation to Treat Foot Drop in People With Multiple Sclerosis Completed NCT02123537
12 Targeted Lower Extremity Joint Training Effects on MS Gait Abnormalities Completed NCT00906737
13 Functional Electrical Stimulation for People With Multiple Sclerosis Who Experience Foot Drop:Feasibility of Instrumented Gait Analysis in Clinical Practice. Completed NCT01914016
14 Adaptive Ankle Robot Control System to Reduce Foot-drop in Chronic Stroke Completed NCT02483676
15 Randomized Trial of the Innovative Neurotronics WalkAide Compared to Conventional Ankle-Foot Orthosis (AFO) in Stroke Patients (INSTRIDE) Completed NCT01087957
16 Identification of Responders to the FES Interventions in Stroke Population Completed NCT01952613
17 Functional Electrical Stimulation for Footdrop in Hemiparesis Completed NCT00148343
18 A Pilot Study to Assess the Effects of Using FES or AFO as an Assistive Mobility for Period of 12 Weeks for People With Multiple Sclerosis With Foot Drop Completed NCT01977287
19 Parameter Changes in Functional Electrical Stimulation Completed NCT03300986
20 A Three-Arm, Randomized Crossover Study Comparing the Innovative Neurotronics WalkAide™ System to Ankle-Foot Orthosis [AFO] Completed NCT00216320
21 Implanted Functional Electrical Stimulation of the Levators of the Ankle Versus Orthosis in the Treatment of Chronic Foot Neurological STEPPAGE-gait by Central Attack Completed NCT01415700
22 Functional Ambulation: Standard Treatment vs. Electronic Stimulation Therapy (FASTEST)Trial in Chronic Post-Stroke Subjects With Foot Drop Completed NCT01138995
23 Clinical Effects of Peroneal Nerve Functional Electrical Stimulation (WalkAide[R]) for the Lower Extremities in Chronic Stroke Patients With Hemiplegia: A Multicenter, Prospective, Randomized Controlled Trial Completed NCT02897752
24 Clinical Study to Evaluate the Implantation of the ActiGait Drop Foot Stimulator System Completed NCT01116466
25 Approach to Continuous Sciatic Nerve Block for Orthopedic Procedures in Day Surgery With Two Different Techniques Completed NCT02029404
26 The Evaluation of Dual Channel vs Single Channel FES for Dropfoot Completed NCT02494323
27 Wearable Interactive Lower-limb Exoskeleton Robotic Device for Gait Training of Post-stroke Patients on Different Walking Conditions Recruiting NCT03184259
28 Effects of Two Different Types of Ankle Foot Orthoses on Gait Outcomes in Patients With Subacute Stroke. Recruiting NCT02693834
29 A Rigid Body Database on Human Movement Recruiting NCT00001252
30 Association Between the Transcranial Direct Current Stimulation (tDCS) and Foot Drop Stimulation (FDS) for Gait Rehabilitation After Stroke - A Randomized Clinical Trial Active, not recruiting NCT04077814
31 The Therapeutic Effects of Peroneal Nerve Functional Electrical Stimulation for Lower Extremity in Patients With Sub-acute Post-stroke Hemiplegia A Randomized Controlled Study Active, not recruiting NCT02898168
32 Multi-pad Functional Electrical Stimulation for Droop Foot Treatment Enrolling by invitation NCT02729636
33 Walking Ankle Robot for Foot Drop in Aging and Disabled Populations: A Demonstration Project Not yet recruiting NCT03556709
34 Seated Ankle Robot for Foot Drop in Aging and Disabled Populations: A Demonstration Project Not yet recruiting NCT03530592
35 The Orthotic Effect of Functional Electrical Stimulation to Treat Foot Drop in People With MS Under Walking Conditions Simulating Those in Daily Life Not yet recruiting NCT03410498
36 TREAT Foot Drop After Stroke With Ankle Robot Not yet recruiting NCT04137809
37 Do Patients Who Receive the IPACK and Adductor Canal Catheter Have Better Outcomes Than Patients Receiving the Adductor Canal Catheter Alone for Total Knee Replacements? Not yet recruiting NCT03774966 Early Phase 1
38 A Wearable for Post-stroke Rehabilitative Multi-muscle Stimulation Inspired by the Natural Organization of Neuromuscular Control Not yet recruiting NCT04154514
39 Use Of Autologous Stem Cell Use In Neurological Non-neoplastic Disorders And Disease Not yet recruiting NCT03297177
40 The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute Lymphoblastic Leukemia and Foot Drop Terminated NCT01001390
41 A Prospective, Randomized Study Comparing Continuous Femoral and Tibial Nerve Blocks vs. Continuous Femoral and Single Shot Sciatic Nerve Block in Total Knee Arthroplasties. Terminated NCT01680692 Early Phase 1 Ropivicaine
42 Acute Nerve Decompression Versus Non-operative Treatment for Peroneal Nerve Palsy Following Primary Total Knee Arthroplasty Withdrawn NCT02856958

Search NIH Clinical Center for Foot Drop

Genetic Tests for Foot Drop

Anatomical Context for Foot Drop

MalaCards organs/tissues related to Foot Drop:

40
Bone, Brain, B Cells, Spinal Cord, Liver, Testes, T Cells

Publications for Foot Drop

Articles related to Foot Drop:

(show top 50) (show all 1182)
# Title Authors PMID Year
1
Permanent damage of the sciatic nerve in an 8-year-old girl with newly diagnosed type 1 diabetes. 61
30739577 2020
2
Utility of motor evoked potentials to diagnose and reduce lower extremity motor nerve root injuries during 4,386 extradural posterior lumbosacral spine procedures. 61
31479780 2020
3
Expanding the clinical and neuroimaging features of NKX6-2-related hereditary spastic ataxia type 8. 61
32004679 2020
4
Rare case of bilateral wrist and foot drop from SLE-related vasculitic polyneuropathy. 61
31948979 2020
5
A Case Study of Puerperal Group A Streptococcal Infection Complicated by Toxic Shock Syndrome. 61
31993244 2020
6
Malignant peripheral nerve sheath tumor of the sciatic nerve presenting with leg pain in the setting of lumbar scoliosis and spinal stenosis. 61
31925758 2020
7
Post-operative analgesia techniques after total knee arthroplasty: A narrative review. 61
31998025 2020
8
Extensor Tendon Transfers for Treatment of Foot Drop in Charcot-Marie-Tooth Disease: A Biomechanical Evaluation. 61
31941350 2020
9
Can Repeated Ponseti Management for Relapsed Clubfeet Produce the Outcome Comparable With the Case Without Relapse? A Clinical Study in Term of Gait Analysis. 61
31815859 2020
10
Lyme Neuroborreliosis in a Patient with Breast Cancer: MRI and PET/CT Findings. 61
31936608 2020
11
Autoimmune polyradiculitis due to combination immunotherapy with ipilimumab and nivolumab for the treatment of metastatic melanoma. 61
31983645 2020
12
Sub-Clinical Peroneal Neuropathy affects Ambulatory, Community Dwelling Adults and is Associated with Falling. 61
31929455 2020
13
[Tendon transfer as a treatment modality of peroneal nerve palsy]. 61
31928619 2020
14
Foot Drop after Ilio-Caval Vein Stenting: Radicular syndrome from stent misplacement in the spinal canal. 61
31954898 2020
15
A Case of Lower Extremity Weakness with Foot Drop Following Intramedullary Nailing of a Pathologic Femoral Fracture. 61
31949995 2020
16
Acute bilateral foot drop due to lumbar disc herniation treated by bilateral interlaminar approach: case report and literature review. 61
31955631 2020
17
Shrinking lakes, air pollution, and human health: Evidence from California's Salton Sea. 61
31931219 2020
18
Primary Total Hip Arthroplasty in Patients 20 Years Old and Younger. 61
31977814 2020
19
Modified bridle tendon transfer procedure following a complete musculature loss of the anterior leg compartment: Case report and literature review. 61
31872026 2019
20
When size does not matter: a rare case of popliteal artery aneurysm presenting with foot drop and its endovascular management. 61
31908761 2019
21
Acute Superficial Peroneal Nerve Entrapment Mimicking Compartment Syndrome: A Case Report. 61
31789667 2019
22
Pseudoaneurysm of the Popliteal Artery Leading to Foot Drop After Arthroscopic Anterior Cruciate Ligament Reconstruction: A Rare Complication: A Case Report. 61
31609751 2019
23
Thrombotic microangiopathy involving kidney allograft and peripheral nerves. 61
31816173 2019
24
Case of atypical cutaneous Mycobacteriumchelonae infection in patient of systemic lupus erythematosus after cyclophosphamide therapy. 61
31818891 2019
25
GNE myopathy - A cross-sectional study on spatio-temporal gait characteristics. 61
31787465 2019
26
A rare case of parasagittal meningioma causing isolated foot drop: case report and review of the literature. 61
31786742 2019
27
Guillain-Barre syndrome observed with adoptive transfer of lymphocytes genetically engineered with an NY-ESO-1 reactive T-cell receptor. 61
31703609 2019
28
Clinical features of Pompe disease with motor neuronopathy. 61
31706699 2019
29
Asymmetric Three-Column Osteotomy for Coronal Malalignment in Adult Patients with Prior Thoracic Fusion for Adolescent Idiopathic Scoliosis: Three-Year Follow-up. 61
31382065 2019
30
Compressive peroneal neuropathy by an intraneural ganglion cyst combined with L5 radiculopathy: A case report. 61
31689879 2019
31
Eribulin-Associated Foot Drop. 61
30570505 2019
32
Neurological Complication After Laparoscopic Sleeve Gastrectomy: Foot Drop. 61
31741213 2019
33
Ipsilateral foot drop after aortobifemoral bypass. 61
31621683 2019
34
Test-retest reliability and minimal detectable change of ankle kinematics and spatiotemporal parameters in MS population. 61
31561120 2019
35
The effect of vascular approach surgeons on perioperative complications in lateral transpsoas lumbar interbody fusions. 61
31669613 2019
36
External iliac artery thrombosis following open reduction of acetabular fracture: a case report and literature review. 61
31642955 2019
37
Pediatric ganglioglioma of the brainstem and cervicomedullary junction: a retrospective cohort study. 61
31585412 2019
38
Case report of a partially thrombosed ACoA aneurysm presenting with bilateral foot drop. 61
31437667 2019
39
The Inherited Neuromuscular Disorder GNE Myopathy: Research to Patient Care. 61
31744945 2019
40
Glial Fibrillary Acidic Protein (GFAP) Autoimmunity in the Setting of Seropositive Rheumatoid Arthritis Treated With Etanercept. 61
31478999 2019
41
Acute sensorimotor polyneuropathy as an early sign of polyarteritis nodosa. A case report. 61
31788663 2019
42
Facet joint cyst haematoma: a rare cause of cauda equina syndrome. 61
31507217 2019
43
Neuromuscular electrical stimulation-promoted plasticity of the human brain. 61
31495924 2019
44
Label Self-Advised Support Vector Machine (LSA-SVM)-Automated Classification of Foot Drop Rehabilitation Case Study. 61
31569694 2019
45
[Surgical Results of Lumbar Degenerative Disease with Foot Drop]. 61
31477628 2019
46
Direct muscle neurotization with long acellular nerve allograft: A case report. 61
31328294 2019
47
Long-term use of implanted peroneal functional electrical stimulation for stroke-affected gait: the effects on muscle and motor nerve. 61
31292003 2019
48
Significant Impact of Implantable Functional Electrical Stimulation on Gait Parameters: A Kinetic Analysis in Foot Drop Patients. 61
30954755 2019
49
Evaluating the Effect of Functional Electrical Stimulation Used for Foot Drop on Aspects of Health-Related Quality of Life in People with Multiple Sclerosis: A Systematic Review. 61
31474810 2019
50
The clinical- and cost-effectiveness of functional electrical stimulation and ankle-foot orthoses for foot drop in Multiple Sclerosis: a multicentre randomized trial. 61
30974955 2019

Variations for Foot Drop

Expression for Foot Drop

Search GEO for disease gene expression data for Foot Drop.

Pathways for Foot Drop

Pathways related to Foot Drop according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.96 PMP22 MPZ
2 10.66 TTN NEB ACTA1

GO Terms for Foot Drop

Cellular components related to Foot Drop according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 Z disc GO:0030018 9.16 TTN NEB
2 striated muscle thin filament GO:0005865 8.96 TTN ACTA1
3 sarcomere GO:0030017 8.8 TTN NEB ACTA1

Biological processes related to Foot Drop according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 muscle contraction GO:0006936 9.32 TTN ACTA1
2 muscle organ development GO:0007517 9.26 NEB FHL1
3 myelination GO:0042552 9.16 PMP22 MPZ
4 skeletal muscle thin filament assembly GO:0030240 8.96 TTN ACTA1
5 muscle filament sliding GO:0030049 8.8 TTN NEB ACTA1

Molecular functions related to Foot Drop according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural constituent of muscle GO:0008307 8.62 TTN NEB

Sources for Foot Drop

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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