MCID: FST001
MIFTS: 33

Foster-Kennedy Syndrome

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Foster-Kennedy Syndrome

MalaCards integrated aliases for Foster-Kennedy Syndrome:

Name: Foster-Kennedy Syndrome 12 17 74
Disorder of the Optic Nerve 74
Optic Nerve Diseases 45

Classifications:



External Ids:

Disease Ontology 12 DOID:14555
ICD9CM 36 377.04
MeSH 45 D009901
SNOMED-CT 69 87764000
ICD10 34 H47.0 H47.14

Summaries for Foster-Kennedy Syndrome

MalaCards based summary : Foster-Kennedy Syndrome, also known as disorder of the optic nerve, is related to optic neuritis and chiasmal syndrome, and has symptoms including sciatica and eye manifestations. The drugs Dorzolamide and Timolol have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and bone.

Wikipedia : 77 Foster–Kennedy syndrome (also known as Gowers–Paton–Kennedy syndrome, Kennedy''s phenomenon or... more...

Related Diseases for Foster-Kennedy Syndrome

Diseases related to Foster-Kennedy Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 31)
# Related Disease Score Top Affiliating Genes
1 optic neuritis 11.0
2 chiasmal syndrome 11.0
3 3-methylglutaconic aciduria, type iii 10.3
4 arachnoiditis 10.3
5 olfactory groove meningioma 10.3
6 optic nerve hypoplasia, bilateral 10.1
7 hydrocephalus due to congenital stenosis of aqueduct of sylvius 10.1
8 nonarteritic anterior ischemic optic neuropathy 10.1
9 retinitis pigmentosa 10.1
10 leber congenital amaurosis 4 10.1
11 nasopharyngeal carcinoma 10.1
12 cataract 10.1
13 diabetes mellitus 10.1
14 ischemic optic neuropathy 10.1
15 vitamin b12 deficiency 10.1
16 papilledema 10.1
17 optic nerve disease 10.1
18 retinitis 10.1
19 plasmacytoma 10.1
20 pituitary adenoma 10.1
21 adenoma 10.1
22 neuropathy 10.1
23 intracranial hypertension 10.1
24 glioma 10.1
25 juvenile nasopharyngeal angiofibroma 10.1
26 onchocerciasis 10.0
27 multiple sclerosis 9.7
28 retinoblastoma 9.7
29 amblyopia 9.7
30 uveitis 9.7
31 retinal disease 9.7

Graphical network of the top 20 diseases related to Foster-Kennedy Syndrome:



Diseases related to Foster-Kennedy Syndrome

Symptoms & Phenotypes for Foster-Kennedy Syndrome

UMLS symptoms related to Foster-Kennedy Syndrome:


sciatica, eye manifestations

Drugs & Therapeutics for Foster-Kennedy Syndrome

Drugs for Foster-Kennedy Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 355)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dorzolamide Approved Phase 4,Phase 2,Not Applicable 120279-96-1 3154 5284549
2
Timolol Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 26839-75-8 33624 5478
3
Mycophenolic acid Approved Phase 4 24280-93-1 446541
4
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Not Applicable 53-03-2 5865
5
Mitoxantrone Approved, Investigational Phase 4 65271-80-9 4212
6
Bevacizumab Approved, Investigational Phase 4,Phase 2,Phase 1,Early Phase 1 216974-75-3
7
Methylprednisolone hemisuccinate Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2921-57-5
8
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 83-43-2 6741
9
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-24-8 5755
10
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 302-25-0
11
Brinzolamide Approved Phase 4,Phase 3 138890-62-7 68844
12
Travoprost Approved Phase 4,Phase 3 157283-68-6 5282226
13
Methotrexate Approved Phase 4 1959-05-2, 59-05-2 126941
14
4-Aminopyridine Approved Phase 4,Phase 2,Phase 3 504-24-5 1727
15
Dopamine Approved Phase 4,Not Applicable 62-31-7, 51-61-6 681
16
Levodopa Approved Phase 4 59-92-7 6047
17
Carbidopa Approved Phase 4 28860-95-9 34359
18
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
19
Diclofenac Approved, Vet_approved Phase 4 15307-86-5 3033
20
Propranolol Approved, Investigational Phase 4 525-66-6 4946
21
Methimazole Approved Phase 4 60-56-0 1349907
22
Amiodarone Approved, Investigational Phase 4 1951-25-3 2157
23
Dronedarone Approved Phase 4 141626-36-0, 141625-93-6 154087
24
Bimatoprost Approved, Investigational Phase 4 155206-00-1 5311027
25
Ranibizumab Approved Phase 4,Phase 2,Phase 1 347396-82-1 459903
26
Interferon beta-1a Approved, Investigational Phase 4 145258-61-3 6438354
27
Idebenone Approved, Investigational Phase 4,Phase 3,Phase 2 58186-27-9
28
Tadalafil Approved, Investigational Phase 4 171596-29-5 110635
29
Minocycline Approved, Investigational Phase 4,Phase 2 10118-90-8 5281021
30
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
31
Isotretinoin Approved Phase 4 4759-48-2 5538 5282379
32
Lymecycline Approved, Investigational Phase 4 992-21-2 5280963
33
Folic Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 1 59-30-3 6037
34
Choline Approved, Nutraceutical Phase 4,Not Applicable 62-49-7 305
35
SB-649868 Experimental, Investigational Phase 4,Phase 1 110-16-7, 110-17-8 444972
36
Prednisolone hemisuccinate Experimental Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 2920-86-7
37 Adrenergic Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
38 Adrenergic beta-Antagonists Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
39 Anti-Arrhythmia Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
40 Carbonic Anhydrase Inhibitors Phase 4,Phase 2,Not Applicable
41 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
42 Adrenergic Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
43 Antihypertensive Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
44 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
45 Adrenergic alpha-Agonists Phase 4,Phase 3,Phase 2,Not Applicable
46 Adrenergic alpha-2 Receptor Agonists Phase 4,Phase 3,Phase 2,Not Applicable
47 Adrenergic Agonists Phase 4,Phase 3,Phase 2,Not Applicable
48 Ophthalmic Solutions Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
49 Brimonidine Tartrate, Timolol Maleate Drug Combination Phase 4
50 Brimonidine Tartrate Phase 4,Phase 3,Phase 2,Not Applicable 70359-46-5

Interventional clinical trials:

(show top 50) (show all 359)
# Name Status NCT ID Phase Drugs
1 Impact of Timolol/Dorzolamide Therapy on Autoregulation in Glaucoma Patients Unknown status NCT02053298 Phase 4 Timolol & Dorzolamide
2 Efficacy and Safety Study of Combigan and 0.5% Timoptic in Normal Tension Glaucoma Unknown status NCT01446497 Phase 4 Brimonidine/Timolol mixed combination;Timolol
3 Mycophenolate Mofetil Treatment With Neuromyelitis Optica Spectrum Disorders in Chinese Patients Unknown status NCT02809079 Phase 4 Mycophenolate mofetil;Prednisone
4 Efficacy and Safety of Mitoxantrone in Patients With Refractory Neuromyelitis Optica and Spectrum Disorders Unknown status NCT02021825 Phase 4 Mitoxantrone
5 Citicoline Effect on Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT03046693 Phase 4 Group A Citicoline 1000 mg oral tablet;Group B placebo oral tablet
6 A New Medicine to Treat Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Completed NCT01975324 Phase 4 dalfampridine;Placebo
7 Effect of Levodopa-Carbidopa on Visual Function in Patients With Recent-Onset Nonarteritic Anterior Ischemic Optic Neuropathy Completed NCT00432393 Phase 4 levodopa-carbidopa
8 Neural Conduction Along the Visual Pathways After Oral Treatment With Citicoline in Patients With Optic Nerve Diseases Completed NCT00404729 Phase 4 Cytidine-5’-diphosphocholine (Citicoline)
9 Use of Bevacizumab in Trabeculectomy Surgery Completed NCT01166594 Phase 4 Bevacizumab;Control
10 Brimonidine vs ALTP in Progressing Human Glaucoma Completed NCT00466479 Phase 4 brimonidine
11 Preoperative Brimonidine on IOP of Patients Undergoing RALP Completed NCT02818816 Phase 4 brimonidine tartrate 0.2%
12 Liver Function After Intravenous Methylprednisolone Administration Completed NCT03667157 Phase 4 every week IVMP therapy;very high doses IVMP therapy
13 Adjuvant Treatment of Graves´ Ophthalmopathy With NSAID (aGO Study) Completed NCT01458600 Phase 4 Diclofenac;Methimazole;L-thyroxin;Propranolol;Metoprolol
14 Pharmacokinetics and Optimal Timing of Dronedarone Initiation Following Long-term Amiodarone in Patients With Paroxysmal or Persistent Atrial Fibrillation Completed NCT01199081 Phase 4 Dronedarone
15 Additive Effect of Twice-daily Brinzolamide 1%/Brimonidine 0.2%Combination as an Adjunctive Therapy to Travoprost in Patients With Normal Tension Glaucoma Completed NCT03150160 Phase 4 brinzolamide 1%/brimonidine 0.2% fixed combination;Placebo;travoprost 0.004% ophthalmic solution
16 Efficacy and Safety of COMBIGAN® in Korean Patients With Primary Open Angle Glaucoma (POAG) and Normal Tension Glaucoma (NTG) Completed NCT02863705 Phase 4 brimonidine tartrate/timolol malate Ophthalmic Solution;bimatoprost ophthalmic solution 0.01%
17 Investigation of Intraocular Pressure (IOP) Reduction Efficacy of Travoprost Ophthalmic Solution in Patients With Normal Tension Glaucoma Completed NCT01995136 Phase 4 Travoprost Ophthalmic Solution 0.004%
18 Treatment of Diabetic Macular Edema (DME) With Anti-VEGF and Focal Laser Completed NCT03590444 Phase 4 Ranibizumab 0.5 MG/0.05 ML Intraocular Solution
19 A Pilot Study of Mitoxantrone for the Treatment of Recurrent Neuromyelitis Optica (Devic’s Disease) Completed NCT00304291 Phase 4 Mitoxantrone
20 Pegaptanib for Retinal Edema Secondary to Diabetic Vascular Disease(Preserve) Study Completed NCT01486238 Phase 4 Macugen® pegaptanib sodium
21 Long Term Study of Avonex Therapy Following a First Attack of Multiple Sclerosis Completed NCT00179478 Phase 4 interferon beta 1a 30 ug IM once weekly
22 Antiacne Medications Pseudotumor Cerebri Recruiting NCT02149615 Phase 4
23 A Trial of Neuroprotection With ACTH in Acute Optic Neuritis Recruiting NCT01838174 Phase 4 ACTHAR Gel (ACTH);IV methylprednisolone (steroids)
24 Study to Assess the Efficacy and Safety of Raxone in LHON Patients Active, not recruiting NCT02774005 Phase 4 Idebenone
25 Peripapillary Blood Flow After Use of Anti-glaucoma Medications: An OCT Angiography Study Active, not recruiting NCT03323164 Phase 4 Timolol Maleate;Brimonidine Tartrate
26 Combined Radiotherapy and Intravenous Steroids for Early Progressive Thyroid Eye Disease Not yet recruiting NCT02339142 Phase 4 intravenous corticosteroids (methylprednisolone)
27 PDE5 Inhibitor Use and Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) Terminated NCT00867815 Phase 4 Diagnostic procedures
28 Retinal Ganglion Cell Function After Intravitreous Ranibizumab in Patients With Diabetic Macular Edema Withdrawn NCT02055911 Phase 4 Ranibizumab
29 Induction Therapy With a Single High Dose Bolus of Intravenous Methotrexate With Leucovorin Rescue, Prior to Initiation of AVONEX® Treatment, in Patients Presenting With a First Acute Demyelinating Event. Withdrawn NCT00037115 Phase 4 interferon beta 1a;methotrexate;methylprednisolone
30 Outcomes of Steroid and Oxygen Therapy Versus Placebo Therapy in Non-arteritic Anterior Ischemic Optic Neuropathy Unknown status NCT02439866 Phase 3 placebo;Intravenous methylprednisolone;normobaric oxygen with face mask
31 Retrobulbar Triamcinolone Acetonide Injection in the Treatment of NA-AION Unknown status NCT02329288 Phase 3 Triamcinolone Acetonide;placebo
32 Intraocular Pressure (IOP) Lowering Effect of Selective Laser Trabeculoplasty Versus Prostaglandin Analogues in Angle Closure Glaucoma Unknown status NCT01004900 Phase 3 Travoprost/ Timolol/ Azopt/ Brimonidine
33 Treatment of Wolfram Syndrome Type 2 With the Chelator Deferiprone and Incretin Based Therapy Unknown status NCT02882477 Phase 2, Phase 3 Deferiprone;Acetylcysteine;Sitagliptin and Metformin
34 Effect of MD1003 in Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis Unknown status NCT02220244 Phase 3 MD1003 100mg capsule
35 Simvastatin Treatment of Patients With Acute Optic Neuritis Unknown status NCT00261326 Phase 3 simvastatin;placebo
36 Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone Unknown status NCT00004645 Phase 3
37 Optic Neuritis Treatment Trial (ONTT) Unknown status NCT00000146 Phase 3 Methylprednisolone;Prednisone
38 Ischemic Optic Neuropathy Decompression Trial (IONDT) Completed NCT00000127 Phase 3
39 A Randomized, Double-blind, Placebo-controlled Trial of Curcumin in Leber's Hereditary Optic Neuropathy (LHON) Completed NCT00528151 Phase 3 curcumin
40 Paraorbital-Occipital Electric Stimulation in Patients With Optic Neuropathy (BCT_optnerve) Completed NCT01282827 Phase 2, Phase 3
41 Optic Neuritis Recovery After Oral or IV Corticosteroids Completed NCT01524250 Phase 2, Phase 3 corticosteroids;corticosteroids
42 A Randomized, Double-blind, Placebo-controlled, Multicenter Study of the Effects of Glatiramer Acetate (GA) on the Retinal Nerve Fiber Layer (RNFL) and Visual Function in Patients With a First Episode of Acute Optic Neuritis (AON). (Octagon) Completed NCT00856635 Phase 3 Glatiramer Acetate;placebo
43 Intravenous Immunoglobulin Therapy in Optic Neuritis Completed NCT00000117 Phase 3 Immunoglobulin
44 Comparison of Clinical Effects of Azathioprine and Rituximab NMO-SD Patients Completed NCT03002038 Phase 2, Phase 3 Azathioprine;Rituximab
45 A Double Blind Trial To Evaluate The Safety And Efficacy Of Eculizumab In Relapsing NMO Patients (PREVENT Study) Completed NCT01892345 Phase 3 Eculizumab
46 Ozurdex for Macular Edema Post Membrane Peeling Completed NCT01273727 Phase 2, Phase 3 Dexamethasone;dexamethasone
47 Ampyra for Optic Neuritis in MS Completed NCT01337986 Phase 2, Phase 3 Dalfampridine/Placebo;Placebo/Dalfampridine
48 Traumatic Optic Neuropathy Treatment Trial 2 Recruiting NCT03308448 Phase 3 Recombinant human erythropoietin
49 Efficacy & Safety of RPh201 Treatment in Patients With Previous Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT03547206 Phase 3 RPh201
50 Phase 2/3, Randomized, Double-Masked, Sham-Controlled Trial of QPI-1007 in Subjects With Acute Nonarteritic Anterior Ischemic Optic Neuropathy (NAION) Recruiting NCT02341560 Phase 2, Phase 3 QPI-1007 Injection - 1.5 mg;QPI-1007 Injection - 3.0 mg

Search NIH Clinical Center for Foster-Kennedy Syndrome

Cochrane evidence based reviews: optic nerve diseases

Genetic Tests for Foster-Kennedy Syndrome

Anatomical Context for Foster-Kennedy Syndrome

MalaCards organs/tissues related to Foster-Kennedy Syndrome:

42
Eye, Brain, Bone, Thyroid, Liver, Testes, T Cells

Publications for Foster-Kennedy Syndrome

Articles related to Foster-Kennedy Syndrome:

(show all 48)
# Title Authors Year
1
Foster Kennedy Syndrome. ( 30690544 )
2019
2
Sequential NAION presenting as pseudo Foster Kennedy syndrome. ( 28431627 )
2017
3
Pseudo-Foster Kennedy Syndrome as a Rare Presentation of Vitamin B12 Deficiency. ( 27621919 )
2016
4
Pseudo-Foster Kennedy Syndrome - a case report. ( 29450361 )
2016
5
Foster Kennedy Syndrome: An Atypical Presentation. ( 26540474 )
2015
6
Pseudo-Foster-Kennedy syndrome with optic nerve compression by the gyrus rectus. ( 26215878 )
2015
7
Pseudo-Foster-Kennedy syndrome with optic nerve compression by the gyrus rectus. ( 26438621 )
2015
8
Localizing the Lesion in Foster Kennedy Syndrome From Hemiretinal Atrophy at the Macula. ( 25225949 )
2014
9
Pseudo-Foster Kennedy syndrome due to idiopathic intracranial hypertension. ( 25103671 )
2014
10
Foster Kennedy Syndrome Due to Meningioma Growth during Pregnancy. ( 24273529 )
2013
11
Foster Kennedy Syndrome: Now and Then. ( 24284554 )
2013
12
An aggressive sphenoid wing meningioma causing foster kennedy syndrome. ( 22666616 )
2012
13
Pseudo-Foster Kennedy syndrome in a young woman with meningioma infiltrating the superior sagittal sinus. ( 22071204 )
2012
14
Foster Kennedy syndrome: papilledema in one eye with optic atrophy in the other eye. ( 21948724 )
2011
15
An unusual presentation of subfrontal meningioma: a case report and literature review for Foster Kennedy syndrome. ( 20740328 )
2011
16
Foster Kennedy Syndrome in a Case with Retinitis Pigmentosa. ( 20337271 )
2010
17
An atypical case of Foster Kennedy syndrome. ( 21162773 )
2010
18
Intracranial meningiomatosis causing foster kennedy syndrome by unilateral optic nerve compression and blockage of the superior sagittal sinus. ( 19491639 )
2009
19
Pseudo-Foster Kennedy Syndrome due to unilateral optic nerve hypoplasia: a case report. ( 18348732 )
2008
20
Victor Horsley's contribution to the Foster Kennedy syndrome. ( 15702837 )
2004
21
Juvenile nasopharyngeal angiofibroma presenting as Foster Kennedy Syndrome. ( 11921556 )
2001
22
Pachymeningitis with pseudo-Foster Kennedy syndrome. ( 11024436 )
2000
23
Nasopharyngeal carcinoma: a cause of Foster Kennedy syndrome. ( 7958054 )
1994
24
Pituitary adenoma presenting as the Foster-Kennedy syndrome. ( 1739707 )
1992
25
A case of Foster Kennedy syndrome without frontal lobe or anterior cranial fossa involvement. ( 1635628 )
1992
26
Foster Kennedy syndrome and optociliary shunt vessels in a patient with an olfactory groove meningioma. ( 1923304 )
1991
27
Pseudo-Foster Kennedy syndrome in a patient with anterior ischemic optic neuropathy and a nonbasal glioma. ( 2144536 )
1990
28
Bilateral optic nerve compression as a mechanism for the Foster Kennedy syndrome. ( 2560156 )
1989
29
Pseudo-pseudo-Foster Kennedy syndrome. ( 2972751 )
1988
30
Foster Kennedy syndrome and an optociliary vein in a patient with a falx meningioma. ( 6233330 )
1984
31
Foster Kennedy syndrome. ( 6372760 )
1984
32
Foster-Kennedy syndrome due to optochiasmatic arachnoiditis. ( 6879420 )
1983
33
Foster-Kennedy syndrome caused by solitary intracranial plasmacytoma. ( 6836481 )
1983
34
Clinical and computed tomographic findings in the Foster Kennedy syndrome. ( 7072795 )
1982
35
Foster Kennedy syndrome, aqueductal stenosis and empty sella. ( 4546807 )
1974
36
Foster Kennedy syndrome. ( 4793005 )
1973
37
Non-tumor causes of the Foster Kennedy syndrome. ( 6028867 )
1967
38
The Foster Kennedy syndrome an evaluation of its diagnostic value. ( 6030724 )
1967
39
Foster-Kennedy syndrome in a case of olfactory-groove meningioma. ( 5830427 )
1965
40
Changes of the optic nerve after cataract extraction simulating the Foster-Kennedy syndrome. ( 14414679 )
1959
41
Aetiopathogenesis of the Foster-Kennedy syndrome. ( 13555648 )
1958
42
Optic atrophy and an ocular complication of diabetes mellitus simulating the Foster Kennedy syndrome. ( 13327809 )
1956
43
Foster Kennedy syndrome produced by myelomatous deposits in the skull. ( 14351755 )
1955
44
Foster Kennedy syndrome. ( 13065386 )
1953
45
Foster-Kennedy syndrome. ( 14885368 )
1951
46
Foster Kennedy syndrome; case report. ( 18140067 )
1949
47
Upper parietal meningioma showing Foster Kennedy syndrome. ( 20247986 )
1947
48
Foster Kennedy syndrome with post-traumatic arachnoiditis of optic chiasm and base of frontal lobes. ( 21012366 )
1945

Variations for Foster-Kennedy Syndrome

Expression for Foster-Kennedy Syndrome

Search GEO for disease gene expression data for Foster-Kennedy Syndrome.

Pathways for Foster-Kennedy Syndrome

GO Terms for Foster-Kennedy Syndrome

Sources for Foster-Kennedy Syndrome

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