MCID: FRN014
MIFTS: 37

Fournier Gangrene

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Fournier Gangrene

MalaCards integrated aliases for Fournier Gangrene:

Name: Fournier Gangrene 52 71
Fournier's Gangrene 52

Classifications:



External Ids:

UMLS 71 C0238419

Summaries for Fournier Gangrene

NIH Rare Diseases : 52 Fournier gangrene refers to the death of body tissue of the genitals and/or perineum. Signs and symptoms of the condition include genital pain, tenderness, redness, and swelling with a rapid progression to gangrene . Although the condition can affect men and women of all ages, it is most commonly diagnosed in adult males. Most cases of Fournier gangrene are caused by an infection in the genital area or urinary tract. People with impaired immunity (i.e. due to diabetes or HIV ) have an increased susceptibility to the condition. Treatment generally includes surgery and medications such as antibiotics and/or antifungal therapy.

MalaCards based summary : Fournier Gangrene, also known as fournier's gangrene, is related to necrotizing fasciitis and acute kidney failure. An important gene associated with Fournier Gangrene is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Immunoglobulin G and Immunologic Factors have been mentioned in the context of this disorder. Affiliated tissues include skin, prostate and kidney, and related phenotypes are homeostasis/metabolism and immune system

Wikipedia : 74 Fournier gangrene is a type of necrotizing fasciitis or gangrene affecting the external genitalia or... more...

Related Diseases for Fournier Gangrene

Diseases related to Fournier Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 491)
# Related Disease Score Top Affiliating Genes
1 necrotizing fasciitis 31.1 F3 ALB
2 acute kidney failure 30.5 F2 ALB
3 calciphylaxis 30.4 CD40LG ALB
4 chickenpox 30.2 CD40LG ALB
5 syphilis 30.2 CD40LG ALB
6 hemorrhoid 30.2 F2 ALB
7 hypersensitivity vasculitis 30.2 CD40LG ALB
8 paralytic ileus 30.1 F2 ALB
9 acute cystitis 30.1 F2 CD40LG ALB
10 thrombocytopenic purpura, autoimmune 30.0 F8 CD40LG
11 disseminated intravascular coagulation 29.9 SERPINC1 F3 F2
12 epidural abscess 29.9 F3 ALB
13 toxic shock syndrome 29.8 SERPINC1 F3 CD40LG
14 lemierre's syndrome 29.7 F3 F2
15 viral hepatitis 29.5 F2 CD40LG ALB
16 respiratory failure 29.2 F3 F2 ALB
17 lung disease 29.2 F3 CD40LG ALB
18 liver cirrhosis 28.9 SERPINC1 F3 F2 ALB
19 peripheral vascular disease 28.8 SERPINC1 F3 F2 ALB
20 exanthem 28.8 F3 F2 CD40LG ALB
21 thrombophilia due to thrombin defect 28.7 SERPINC1 F8 F3 F2
22 purpura 28.7 SERPINC1 F3 F2 CD40LG
23 thrombocytopenia 28.5 SERPINC1 F3 F2 CD40LG ALB
24 thrombosis 28.2 SERPINC1 F8 F3 F2 CD40LG
25 compartment syndrome 28.2 SERPINC1 F8 F3 F2 ALB
26 diabetes mellitus 27.9 SERPINC1 F8 F3 F2 CD40LG ALB
27 pulmonary embolism 27.7 SERPINC1 F8 F3 F2 CD40LG ALB
28 thrombophlebitis 27.6 SERPINC1 F8 F3 F2 CD40LG ALB
29 vascular disease 27.6 SERPINC1 F8 F3 F2 CD40LG ALB
30 fasciitis 10.9
31 rectum cancer 10.5
32 granulocytopenia 10.4
33 alcohol dependence 10.4
34 alcohol use disorder 10.4
35 necrotizing soft tissue infection 10.4
36 gas gangrene 10.3
37 acute promyelocytic leukemia 10.3
38 impotence 10.3
39 end stage renal failure 10.3
40 myositis 10.2
41 metabolic acidosis 10.2
42 lymphocytic leukemia 10.2
43 vasculitis 10.2
44 epididymo-orchitis 10.2
45 hydrocele 10.2
46 syphilitic meningitis 10.2 SERPINC1 CD40LG
47 urethral stricture 10.2
48 rectum adenocarcinoma 10.2
49 spinal cord injury 10.2
50 riedel's fibrosing thyroiditis 10.2 CD40LG ALB

Graphical network of the top 20 diseases related to Fournier Gangrene:



Diseases related to Fournier Gangrene

Symptoms & Phenotypes for Fournier Gangrene

MGI Mouse Phenotypes related to Fournier Gangrene:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 ALB CD40LG F2 F3 F8 SERPINC1
2 immune system MP:0005387 9.1 ALB CD40LG F2 F3 F8 SERPINC1

Drugs & Therapeutics for Fournier Gangrene

Drugs for Fournier Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunoglobulin G Phase 2
2 Immunologic Factors Phase 2
3 Immunoglobulins Phase 2
4 Antibodies Phase 2
5 Immunoglobulins, Intravenous Phase 2
6 Rho(D) Immune Globulin Phase 2
7 gamma-Globulins Phase 2
8
Protein C Approved
9
Daptomycin Approved, Investigational 103060-53-3 16129629
10
Alogliptin Approved 850649-61-5 11450633
11
Zinc Approved, Investigational 7440-66-6 32051
12
Saxagliptin Approved 361442-04-8 11243969
13
Metformin Approved 657-24-9 14219 4091
14
Linagliptin Approved 668270-12-0 10096344
15
Vildagliptin Approved, Investigational 274901-16-5 6918537
16
Empagliflozin Approved 864070-44-0
17
Canagliflozin Approved 842133-18-0
18
2,4-thiazolidinedione Investigational 2295-31-0
19 Anti-Bacterial Agents
20 Anti-Infective Agents
21
protease inhibitors
22 HIV Protease Inhibitors
23 Sodium-Glucose Transporter 2 Inhibitors
24 Hypoglycemic Agents
25 Sitagliptin Phosphate
26 Dipeptidyl-Peptidase IV Inhibitors
27 insulin
28 Meglitinide
29 Insulin, Globin Zinc
30 Glucagon-Like Peptide 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Study of AB103 as Compared to Placebo in Patients With Necrotizing Soft Tissue Infections. ACCUTE (AB103 Clinical Composite Endpoint Study in Necrotizing Soft Tissue Infections) Active, not recruiting NCT02469857 Phase 3 AB103 0.5 mg/kg
2 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
3 Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Completed NCT03443544
4 Biomarkers in Necrotizing Soft Tissue Infections - Effects of Hyperbaric Oxygen Treatment on the Immune Response Completed NCT02501382
5 Biomarkers in Necrotizing Soft Tissue Infections - Aspects of the Innate Immune Response Completed NCT02180906
6 ProTreat - Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Completed NCT03147352
7 Raised Serum Lactate as a Marker of Necrotizing Fasciitis; a Consecutive Prospective Review. Completed NCT01739959
8 Open Label, Single Center Study to Evaluate Higher Doses of Daptomycin in the Treatment of Patients With Severe Necrotizing Skin and Soft Tissue Infections. Completed NCT00261807 Daptomycin 6mg/kg/day
9 Safety of Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors Among Patients With Type 2 Diabetes: a Multicenter Cohort Study Active, not recruiting NCT04017221 Sodium-glucose cotransporter 2 (SGLT2) inhibitors;Dipeptidyl peptidase-4 (DPP-4) inhibitors;Other treatment combinations

Search NIH Clinical Center for Fournier Gangrene

Genetic Tests for Fournier Gangrene

Anatomical Context for Fournier Gangrene

MalaCards organs/tissues related to Fournier Gangrene:

40
Skin, Prostate, Kidney, Heart, Spinal Cord, Liver, Myeloid

Publications for Fournier Gangrene

Articles related to Fournier Gangrene:

(show top 50) (show all 1197)
# Title Authors PMID Year
1
Skin Infections and Outpatient Burn Management: Skin Infections in Patients With Diabetes. 61
31995351 2020
2
Complete Recovery of Immune Checkpoint Inhibitor-induced Colitis by Diverting Loop Ileostomy. 61
32028372 2020
3
Fournier's gangrene and sodium-glucose co-transporter-2 inhibitors: A meta-analysis of randomized controlled trials. 61
31637829 2020
4
Fournier's gangrene in patients with type 2 diabetes using second-line antidiabetic medications. 61
31576637 2020
5
Fournier's gangrene mortality; A 17- year systematic review and meta-analysis. 61
31962181 2020
6
[Fournier's gangrene as special form of necrotizing fasciitis]. 61
31965200 2020
7
Using the World Society of Emergency Surgery (WSES) Triage Tool to Evaluate Timing of Emergency Surgery in Rwanda. 61
31933043 2020
8
Real-world evidence on sodium-glucose cotransporter-2 inhibitor use and risk of Fournier's gangrene. 61
31958306 2020
9
[Advances in the research of Fournier gangrene]. 61
32023723 2020
10
Bilobed Gracilis Flap: A Novel Alternative for Pelvic and Perineal Reconstruction. 61
31592948 2020
11
Beware of Perianal Pain: Fournier's Gangrene. 61
31926862 2020
12
Comparison of Mortality in Fournier's Gangrene with the Two Scoring Systems. 61
31931936 2020
13
Acute management of Fournier's gangrene in the setting of massive lymphedema. 61
31641598 2020
14
Mortality associated with Fourniere's Gangrene remains unchanged over 25 years. 61
31975540 2020
15
Outcomes of patients with Fournier's Gangrene: 12-year experience from a tertiary care referral center. 61
32027590 2019
16
Idarucizumab for Reversal of Dabigatran in Early/Emergency Surgeries: A Case Series. 61
31662218 2019
17
Etiology of Fournier gangrene as a prognostic factor in mortality: Analysis of 121 cases. 61
31399259 2019
18
[Management of Fournier gangrene in perineal region by negative-pressure wound therapy combined with delayed repair]. 61
31877610 2019
19
Safety of Ipragliflozin in Patients with Type 2 Diabetes Mellitus: Pooled Analysis of Phase II/III/IV Clinical Trials. 61
31606880 2019
20
Impact of radiological diagnostics in the survivor of disseminated Fournier gangrene patient with septic pulmonary embolism. 61
31852690 2019
21
Imaging of the acute scrotum: keys to a rapid diagnosis of acute scrotal disorders. 61
31748822 2019
22
Fournier's gangrene secondary to locally advanced prostate cancer: case report and review of the Literature. 61
32007109 2019
23
Acute Scrotal Emergencies. 61
31563197 2019
24
A curious case of Fournier's gangrene. 61
31516834 2019
25
Fournier Gangrene in Poorly Controlled Type 1 Diabetes. 61
31620988 2019
26
Fournier Gangrene: A Review for Emergency Clinicians. 61
31472943 2019
27
A case report of necrotizing fasciitis with growth of Actinomyces europaeus and Actinotignum schaalii. 61
31636892 2019
28
Fournier's Gangrene in a Patient with Type 2 Diabetes Mellitus Treated with Empagliflozin: A Case Report. 61
31628552 2019
29
More Than Just Torsion: An Unusual Case of Testicular Pain. 61
31665410 2019
30
Image Gallery: Fournier gangrene in a patient with severe hidradenitis suppurativa. 61
31240692 2019
31
Extensive necrotizing fasciitis from Fournier's gangrene. 61
31236328 2019
32
Potential of hyperbaric oxygen in urological diseases. 61
31083787 2019
33
Association of Sodium-Glucose Cotransporter 2 Inhibitor Treatment With Risk of Hospitalization for Fournier Gangrene Among Men. 61
31479145 2019
34
Fournier's Gangrene Following Piquerism. 61
31227101 2019
35
A different perspective for morbidity related to Fournier's gangrene: which scoring system is more reliable to predict requirement of skin graft and flaps in survivors of Fournier's gangrene? 61
31177367 2019
36
Fournier's gangrene: a modern analysis of predictors of outcomes. 61
31555561 2019
37
MHRA drug safety update: risk of Fournier's gangrene with SGLT2 inhibitors for diabetes. 61
31345956 2019
38
Factors associated with readmission and mortality in adult patients with skin and soft tissue infections. 61
30770547 2019
39
SGLT2 Inhibitors: A Review of Their Antidiabetic and Cardioprotective Effects. 61
31426529 2019
40
Fournier's gangrene: Review of 36 cases. 61
31475324 2019
41
[The nightmare of calciphylaxis]. 61
31344746 2019
42
Self-insertion of an odd urethral foreign body that led to Fournier's gangrene. 61
31413515 2019
43
Incorporating Simplified Fournier's Gangrene Severity Index with early surgical intervention can maximize survival in high-risk Fournier's gangrene patients. 61
31001902 2019
44
Editorial Comment to Incorporating Simplified Fournier's Gangrene Severity Index with early surgical intervention can maximize survival in high-risk Fournier's gangrene patients. 61
31131485 2019
45
Early Presentation of a Rare Complication of Sodium-Glucose Cotransporter-2 Inhibitors 10 Days After Initiation: Case Report and Literature Review. 61
31423402 2019
46
Outcomes in patients with Fournier's gangrene originating from the anorectal region with a particular focus on those without perineal involvement. 61
31217986 2019
47
A Reliable Technique in the Reconstruction of Large Penoscrotal Defect: Internal Pudendal Artery Perforator Flap. 61
30880073 2019
48
Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole: Correspondence. 61
30778952 2019
49
Novel Scrotal Reconstruction after Fournier's Gangrene Using the Integra™ Dermal Regeneration Template. 61
30822483 2019
50
Rare isolation of Fusobacterium varium from a case of Fournier's gangrene. 61
30951829 2019

Variations for Fournier Gangrene

Expression for Fournier Gangrene

Search GEO for disease gene expression data for Fournier Gangrene.

Pathways for Fournier Gangrene

GO Terms for Fournier Gangrene

Cellular components related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 SERPINC1 F8 F3 F2 CD40LG ALB
2 collagen-containing extracellular matrix GO:0062023 9.5 SERPINC1 F3 F2
3 blood microparticle GO:0072562 9.43 SERPINC1 F2 ALB
4 platelet alpha granule lumen GO:0031093 9.37 F8 ALB
5 endoplasmic reticulum lumen GO:0005788 9.26 SERPINC1 F8 F2 ALB
6 extracellular space GO:0005615 9.1 SERPINC1 F8 F3 F2 CD40LG ALB

Biological processes related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.54 SERPINC1 F2 ALB
2 acute-phase response GO:0006953 9.4 F8 F2
3 platelet activation GO:0030168 9.33 F8 F2 CD40LG
4 blood coagulation, intrinsic pathway GO:0007597 9.32 F8 F2
5 regulation of blood coagulation GO:0030193 9.26 SERPINC1 F2
6 blood coagulation GO:0007596 9.26 SERPINC1 F8 F3 F2
7 hemostasis GO:0007599 8.92 SERPINC1 F8 F3 F2

Molecular functions related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.62 F8 ALB

Sources for Fournier Gangrene

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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