MCID: FRN014
MIFTS: 40

Fournier Gangrene

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Fournier Gangrene

MalaCards integrated aliases for Fournier Gangrene:

Name: Fournier Gangrene 53 73
Fournier's Gangrene 53

Classifications:



External Ids:

UMLS 73 C0238419

Summaries for Fournier Gangrene

NIH Rare Diseases : 53 Fournier gangrene refers to the death of body tissue of the genitals and/or perineum. Signs and symptoms of the condition include genital pain, tenderness, redness, and swelling with a rapid progression to gangrene. Although the condition can affect men and women of all ages, it is most commonly diagnosed in adult males. Most cases of Fournier gangrene are caused by an infection in the genital area or urinary tract. People with impaired immunity (i.e. due to diabetes or HIV) have an increased susceptibility to the condition. Treatment generally includes surgery and medications such as antibiotics and/or antifungal therapy.

MalaCards based summary : Fournier Gangrene, also known as fournier's gangrene, is related to thrombosis and fasciitis. An important gene associated with Fournier Gangrene is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Immunologic Factors and Immunoglobulins, Intravenous have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and prostate, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 Fournier gangrene is a type of necrotizing fasciitis or gangrene affecting the external genitalia and/or... more...

Related Diseases for Fournier Gangrene

Diseases related to Fournier Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 182)
# Related Disease Score Top Affiliating Genes
1 thrombosis 29.3 F2 F3 F8 SERPINC1
2 fasciitis 10.3
3 necrotizing fasciitis 10.3
4 legg-calve-perthes disease 10.1 CD40LG SERPINC1
5 aleutian mink disease 10.1 ALB CD40LG
6 spinal cord injury 10.1
7 spinal cord infarction 10.1 F2 SERPINC1
8 alpha-2-plasmin inhibitor deficiency 10.1 F2 SERPINC1
9 intracranial embolism 10.1 F2 SERPINC1
10 pneumocystosis 10.1 ALB CD40LG
11 prothrombin deficiency, congenital 10.1 F2 SERPINC1
12 ischemic colitis 10.1 F2 SERPINC1
13 subendocardial myocardial infarction 10.1 F2 SERPINC1
14 alpha-1-antitrypsin deficiency 10.1 ALB SERPINC1
15 sneddon syndrome 10.1 F2 SERPINC1
16 retinal vascular occlusion 10.1 F2 SERPINC1
17 anterior spinal artery syndrome 10.1 F2 SERPINC1
18 thyroid crisis 10.1 ALB F8
19 antithrombin iii deficiency 10.1 F2 SERPINC1
20 central retinal vein occlusion 10.1 F2 SERPINC1
21 retinal vein occlusion 10.1 F2 SERPINC1
22 meningoencephalitis 10.1 ALB CD40LG
23 portal vein thrombosis 10.1 F2 SERPINC1
24 antipyrine metabolism 10.1 ALB F2
25 non-a-e hepatitis 10.1 ALB F2
26 epstein-barr virus hepatitis 10.1 ALB F2
27 placental abruption 10.1 F2 SERPINC1
28 protein c deficiency 10.1 F2 SERPINC1
29 abdominal tuberculosis 10.1 ALB F2
30 severe pre-eclampsia 10.1 ALB SERPINC1
31 ischemic optic neuropathy 10.1 F2 SERPINC1
32 hepatic tuberculosis 10.1 ALB F2
33 brachydactyly, type d 10.1 F2 F8
34 kwashiorkor 10.0 ALB F2
35 hepatic coma 10.0 ALB F2
36 vitamin k deficiency hemorrhagic disease 10.0 F2 F8
37 infantile liver failure syndrome 1 10.0 ALB F2
38 nonarteritic anterior ischemic optic neuropathy 10.0 F2 SERPINC1
39 factor viii deficiency 10.0 F2 F8
40 testicular yolk sac tumor 10.0 ALB F8
41 cardiac tamponade 10.0 F2 F8
42 ascending cholangitis 10.0 ALB F2
43 cholangitis 10.0 ALB F2
44 hepatorenal syndrome 10.0 ALB F2
45 choledocholithiasis 10.0 ALB F2
46 autoimmune disease of urogenital tract 10.0 ALB F2
47 osteonecrosis 10.0 F2 SERPINC1
48 acute liver failure 10.0 ALB F2
49 iga glomerulonephritis 10.0 ALB CD40LG
50 bile duct disease 10.0 ALB F2

Graphical network of the top 20 diseases related to Fournier Gangrene:



Diseases related to Fournier Gangrene

Symptoms & Phenotypes for Fournier Gangrene

MGI Mouse Phenotypes related to Fournier Gangrene:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.55 CD40LG F2 F3 F8 SERPINC1
2 homeostasis/metabolism MP:0005376 9.43 ALB CD40LG F2 F3 F8 SERPINC1
3 mortality/aging MP:0010768 9.1 ALB CD40LG F2 F3 F8 SERPINC1

Drugs & Therapeutics for Fournier Gangrene

Drugs for Fournier Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Immunologic Factors Phase 2
2 Immunoglobulins, Intravenous Phase 2
3 Immunoglobulins Phase 2
4 gamma-Globulins Phase 2
5 Immunoglobulin G Phase 2
6 Rho(D) Immune Globulin Phase 2
7 Antibodies Phase 2
8
Daptomycin Approved, Investigational Not Applicable 103060-53-3 16129629
9
Protein C Approved
10 Anti-Infective Agents Not Applicable
11 Anti-Bacterial Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections Recruiting NCT02469857 Phase 3 AB103 0.5 mg/kg
2 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
3 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
4 Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Completed NCT03443544
5 Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections Completed NCT00261807 Not Applicable Daptomycin 6mg/kg/day
6 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
7 Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing Fasciitis Completed NCT01739959
8 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352

Search NIH Clinical Center for Fournier Gangrene

Genetic Tests for Fournier Gangrene

Anatomical Context for Fournier Gangrene

MalaCards organs/tissues related to Fournier Gangrene:

41
Skin, Spinal Cord, Prostate, Liver, Heart, Thyroid, Placenta

Publications for Fournier Gangrene

Articles related to Fournier Gangrene:

(show top 50) (show all 661)
# Title Authors Year
1
Fournier Gangrene in a patient receiving chemo-radiation for rectal cancer. ( 29507738 )
2018
2
Fournier Gangrene: Association of Mortality with the Complete Blood Count Parameters. ( 29952902 )
2018
3
Suture Technique to Prevent Air Leakage during Negative-Pressure Wound Therapy in Fournier Gangrene. ( 29464174 )
2018
4
Fournier gangrene: a rare case of necrotizing fasciitis of the entire right hemi-pelvis in a diabetic female. ( 29479450 )
2018
5
Fournier's Gangrene Masking as Perineal and Scrotal Cellulitis. ( 30041909 )
2018
6
Fournier's gangrene: a rare manifestation of Chikungunya fever. ( 29316869 )
2018
7
Fatal Fournier's gangrene caused by Clostridium ramosum in a patient with central diabetes insipidus and insulin-dependent diabetes mellitus: a case report. ( 30071825 )
2018
8
Preoperative CT Findings and Interobserver Reliability of Fournier Gangrene. ( 30085837 )
2018
9
Fournier gangrene: an historical reappraisal. ( 30182399 )
2018
10
Fournier gangrene due to Rhizobium Radiobacter. ( 30190775 )
2018
11
Fournier gangrene. ( 30192736 )
2018
12
Sudden unexpected death due to Fournier gangrene. ( 30232701 )
2018
13
Factors Affecting Mortality in Fournier Gangrene: A Single Center Experience. ( 30403562 )
2018
14
Analysis of prognostic factors affecting poor outcomes in 41 cases of Fournier gangrene. ( 30505824 )
2018
15
"Letter to the Editor: Fournier Gangrene: Association of Mortality with the Complete Blood Count Parameters." ( 30516745 )
2018
16
Letter to the editor: Fournier Gangrene: Association of Mortality with the Complete Blood Count Parameters. ( 30516752 )
2018
17
A fatal case of Fournier's gangrene during neoadjuvant radiotherapy for rectal cancer. ( 30470845 )
2018
18
Fournier's gangrene caused by penetration of a rectal cancer followed by neoadjuvant chemotherapy. ( 30259251 )
2018
19
Sacral Pressure Ulcer-induced Fournier's Gangrene Extending to the Retroperitoneum: A Case Report. ( 29406297 )
2018
20
Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole. ( 30328081 )
2018
21
Desperate need for better management of Fournier's gangrene. ( 30386661 )
2018
22
Fournier's Gangrene of the Penis following a Human Bite Wound. ( 30498616 )
2018
23
Minimal invasive laparoscopic harvest of the greater omental flap for Fournier's gangrene scrotal reconstruction. ( 30527712 )
2018
24
Fournier's gangrene caused by Streptococcus anginosus, a rare etiologic agent. ( 28676193 )
2018
25
Risk factors for mortality in fournier's gangrene in a general hospital: use of simplified founier gangrene severe index score (SFGSI). ( 28853819 )
2018
26
Emergence of multi-drug resistant organisms (MDROs) causing Fournier's gangrene. ( 28962969 )
2018
27
Re: Simplified Fournier's gangrene severe index score (SFGSI). ( 29135415 )
2018
28
Use of photodynamic inactivation for in vitro reduction of prevalent bacteria in Fournier's Gangrene. ( 29219279 )
2018
29
Surviving Fournier's gangrene: Multivariable analysis and a novel scoring system to predict length of stay. ( 29284566 )
2018
30
Fournier's Gangrene: Clinical Presentation of 13 Cases. ( 29374769 )
2018
31
Isolated Involvement of Penis in Fournier's Gangrene: A Rare Possibility. ( 29394981 )
2018
32
Coverage of the scrotum after Fournier's gangrene. ( 29423355 )
2018
33
Definitive Wound Closure Techniques in Fournier's Gangrene. ( 29428033 )
2018
34
Profile of patients with Fournier's gangrene and their clinical evolution. ( 29451646 )
2018
35
Fournier's gangrene in an obese female in third trimester of pregnancy. ( 29619495 )
2018
36
FOURNIER'S GANGRENE, A RARE COMPLICATION OF DIABETES MELLITUS (CASE REPORT). ( 29745916 )
2018
37
A Rare Case of Localised Isolated Penile Fournier's Gangrene and a Short Review of the Literature. ( 29854551 )
2018
38
Fournier's Gangrene: Literature Review and Clinical Cases. ( 29949811 )
2018
39
A contemporary case series of Fournier's gangrene at a Swiss tertiary care center-can scoring systems accurately predict mortality and morbidity? ( 29977327 )
2018
40
Case report: treatment of Fournier's gangrene of the shoulder girdle. ( 30027085 )
2018
41
Fournier's Gangrene Does Not Spare Young Adults. ( 30059341 )
2018
42
Fournier's gangrene: not as lethal as previously thought? A case series. ( 30173412 )
2018
43
The presentation, management and outcomes of Fournier's gangrene at a tertiary urology referral centre in South Africa. ( 30182884 )
2018
44
Isolated Fournier's gangrene of the penis with penile autoamputation. ( 30232209 )
2018
45
Fournier's gangrene: outcome analysis and prognostic factors. ( 30264942 )
2018
46
Outcomes in Fournier's Gangrene Using Skin and Soft Tissue Sparing Flap Preservation Surgery for Wound Closure: An Alternative Approach to Wide Radical Debridement. ( 30299266 )
2018
47
Significance of Hyperbaric Oxygenation in the Treatment of Fournier's Gangrene: A Comparative Study. ( 30326483 )
2018
48
A fascia lata free flap in pelvic exenteration for Fournier gangrene due to advanced rectal cancer: a case report. ( 28550641 )
2017
49
Using negative pressure therapy for improving skin graft taking on genital area defects following Fournier gangrene. ( 28861313 )
2017
50
Presentation and Diagnosis of Fournier Gangrene. ( 29146218 )
2017

Variations for Fournier Gangrene

Expression for Fournier Gangrene

Search GEO for disease gene expression data for Fournier Gangrene.

GO Terms for Fournier Gangrene

Cellular components related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 ALB CD40LG F2 F3 F8 SERPINC1
2 blood microparticle GO:0072562 9.43 ALB F2 SERPINC1
3 platelet alpha granule lumen GO:0031093 9.32 ALB F8
4 endoplasmic reticulum lumen GO:0005788 9.26 ALB F2 F8 SERPINC1
5 extracellular space GO:0005615 9.1 ALB CD40LG F2 F3 F8 SERPINC1

Biological processes related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.54 ALB F2 SERPINC1
2 acute-phase response GO:0006953 9.4 F2 F8
3 platelet activation GO:0030168 9.33 CD40LG F2 F8
4 blood coagulation, intrinsic pathway GO:0007597 9.32 F2 F8
5 regulation of blood coagulation GO:0030193 9.26 F2 SERPINC1
6 blood coagulation GO:0007596 9.26 F2 F3 F8 SERPINC1
7 hemostasis GO:0007599 8.92 F2 F3 F8 SERPINC1

Molecular functions related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.62 ALB F8

Sources for Fournier Gangrene

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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