MCID: FRN014
MIFTS: 26

Fournier Gangrene

Categories: Immune diseases, Rare diseases, Reproductive diseases
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Aliases & Classifications for Fournier Gangrene

MalaCards integrated aliases for Fournier Gangrene:

Name: Fournier Gangrene 19 75 71
Fournier's Gangrene 19

Classifications:



External Ids:

UMLS 71 C0238419

Summaries for Fournier Gangrene

GARD: 19 Fournier gangrene refers to the death of body tissue of the genitals and/or perineum. Signs and symptoms of the condition include genital pain, tenderness, redness, and swelling with a rapid progression to gangrene. Although the condition can affect men and women of all ages, it is most commonly diagnosed in adult males. Most cases of Fournier gangrene are caused by an infection in the genital area or urinary tract. People with impaired immunity (i.e. due to diabetes or HIV) have an increased susceptibility to the condition.

MalaCards based summary: Fournier Gangrene, also known as fournier's gangrene, is related to fasciitis and necrotizing fasciitis. The drugs gamma-Globulins and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and testes.

Wikipedia: 75 Fournier gangrene is a type of necrotizing fasciitis or gangrene affecting the external genitalia or... more...

Related Diseases for Fournier Gangrene

Diseases related to Fournier Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 265)
# Related Disease Score Top Affiliating Genes
1 fasciitis 10.8
2 necrotizing fasciitis 10.8
3 alcohol use disorder 10.5
4 urinary tract infection 10.5
5 disseminated intravascular coagulation 10.5
6 alcohol dependence 10.4
7 rectum cancer 10.4
8 leukemia, acute myeloid 10.4
9 granulocytopenia 10.4
10 neutrophilia, hereditary 10.4
11 acute myeloid leukemia with recurrent genetic anomaly 10.4
12 rectal benign neoplasm 10.4
13 necrotizing soft tissue infection 10.4
14 enterocele 10.4
15 appendicitis 10.4
16 toxic shock syndrome 10.4
17 immune deficiency disease 10.3
18 ataxia with vitamin e deficiency 10.3
19 hematologic cancer 10.3
20 short stature, onychodysplasia, facial dysmorphism, and hypotrichosis 10.3
21 metabolic acidosis 10.3
22 impotence 10.3
23 turner syndrome 10.3
24 end stage renal disease 10.3
25 viral infectious disease 10.3
26 hydrocele 10.3
27 cellulitis 10.2
28 gas gangrene 10.2
29 myositis 10.2
30 charge syndrome 10.2
31 leukemia, acute lymphoblastic 10.2
32 peripheral vascular disease 10.2
33 respiratory failure 10.2
34 adult respiratory distress syndrome 10.2
35 klebsiella pneumonia 10.2
36 thrombocytopenia 10.2
37 congestive heart failure 10.2
38 paraplegia 10.2
39 diverticulitis 10.2
40 vasculitis 10.2
41 myeloid leukemia 10.2
42 decubitus ulcer 10.2
43 epididymo-orchitis 10.2
44 thrombophilia due to thrombin defect 10.2
45 type 1 diabetes mellitus 10.2
46 disease by infectious agent 10.2
47 nephrotic syndrome 10.2
48 urethral stricture 10.2
49 rectum adenocarcinoma 10.2
50 chronic kidney disease 10.2

Graphical network of the top 20 diseases related to Fournier Gangrene:



Diseases related to Fournier Gangrene

Symptoms & Phenotypes for Fournier Gangrene

Drugs & Therapeutics for Fournier Gangrene

Drugs for Fournier Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 gamma-Globulins Phase 2
2 Antibodies Phase 2
3 Rho(D) Immune Globulin Phase 2
4 Immunologic Factors Phase 2
5 Immunoglobulins, Intravenous Phase 2
6 Immunoglobulins Phase 2
7 Immunoglobulin G Phase 2
8
Protein C Approved
9
Daptomycin Approved, Investigational 103060-53-3 16129629
10 Anti-Infective Agents
11 Anti-Bacterial Agents

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Study of AB103 as Compared to Placebo in Patients With Necrotizing Soft Tissue Infections. ACCUTE (AB103 Clinical Composite Endpoint Study in Necrotizing Soft Tissue Infections) Completed NCT02469857 Phase 3 AB103 0.5 mg/kg
2 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
3 Fournier's Gangrene: Seven Years of Experience in the Emergencies Service of Visceral Surgery at Ibn Rochd UHC Completed NCT04983056
4 Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Completed NCT03443544
5 Biomarkers in Necrotizing Soft Tissue Infections - Aspects of the Innate Immune Response Completed NCT02180906
6 Fournier's Gangrene as a Rare Complication in Patient With Uncontrolled Type 2 Diabetes Treated With Surgical Debridement: a Case Report and Literature Review Completed NCT04694053
7 Biomarkers in Necrotizing Soft Tissue Infections - Effects of Hyperbaric Oxygen Treatment on the Immune Response Completed NCT02501382
8 ProTreat - Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Completed NCT03147352
9 Open Label, Single Center Study to Evaluate Higher Doses of Daptomycin in the Treatment of Patients With Severe Necrotizing Skin and Soft Tissue Infections. Completed NCT00261807 Daptomycin 6mg/kg/day
10 The Cytokines and Immune Checkpoint Differences Between Fournier Gangrene and Perianal Abscess Recruiting NCT05529628
11 SKin and Soft Tissue Necrotizing INfections in the Intensive Care Unit: a Prospective Multi-national Cohort Study Recruiting NCT05116956

Search NIH Clinical Center for Fournier Gangrene

Genetic Tests for Fournier Gangrene

Anatomical Context for Fournier Gangrene

Organs/tissues related to Fournier Gangrene:

MalaCards : Skin, Spinal Cord, Testes, Prostate, Colon, Appendix, Myeloid

Publications for Fournier Gangrene

Articles related to Fournier Gangrene:

(show top 50) (show all 1420)
# Title Authors PMID Year
1
Low-energy Shockwave Therapy in the Management of Wound Healing Following Fournier's Gangrene. 62
36131850 2022
2
Global outcomes and lessons learned in the management of Fournier's gangrene from high-volume centres: findings from a literature review over the last two decades. 62
36059020 2022
3
Case - Testicular thigh pouches for severe Fournier's gangrene: A how-to guide. 62
35621290 2022
4
Genital Reconstruction following Fournier's Gangrene. 62
36028436 2022
5
[Diagnosis and Treatment of Severe Fournier's Gangrene: Introduction of a Surgical Approach, Evaluation of Risk Factors, Microbiological Characteristics and Review of the Literature]. 62
33556981 2022
6
Pedicled Superficial Circumflex Iliac Artery Perforator (SCIP) flap for perineo-scrotal reconstruction following Fournier's gangrene. 62
36181427 2022
7
Fournier's gangrene with prostatic and bladder trigone colliquation: a suggested treatment algorithm. 62
36162966 2022
8
Our experience on Fournier's gangrene in a tertiary-stage care center and analysis of its relationship with blood count parameters. 62
36043926 2022
9
Distinctions between Fournier's gangrene and lower extremity necrotising fasciitis: microbiology and factors affecting mortality. 62
35598736 2022
10
Lesion Length as a Prognosis Marker of Mortality in Patients with Fournier's Gangrene: Proposal of a New Scoring System. 62
36214148 2022
11
Prodromal Fournier's Gangrene: A Potential Opportunity for Early Intervention. 62
36073867 2022
12
Fournier's gangrene in a COVID-19 patient with multiple comorbidities: Combatting the triple threat. 62
35389557 2022
13
Hyperbaric oxygen therapy in Fournier's gangrene. 62
35838502 2022
14
Regional Variations in Microbiology and Outcomes of Necrotizing Soft Tissue Infections: A Systematic Review and Meta-Analysis. 62
35904966 2022
15
The role of hyperbaric oxygen therapy in Fournier's Gangrene: A systematic review and meta-analysis of observational studies. 62
35594328 2022
16
A Rare but Life-Threatening Case of Fournier's Gangrene Caused by Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitor, Empagliflozin. 62
36262942 2022
17
Reconstruction of the male external genitalia in diverse disease processes: Our reconstructive algorithm, techniques, and experience. 62
36204359 2022
18
A 30-Day-Old Infant with Necrotizing Fasciitis of the Perineal Region Involving the Scrotum Due to Methicillin-Resistant Staphylococcus aureus (MRSA) and Extended-Spectrum β-Lactamase (ESBL)-Producing Klebsiella pneumoniae: A Case Report. 62
36168215 2022
19
Fatal consequence after MiraDry® treatment: Necrotizing fasciitis complicated with streptococcal toxic shock syndrome. 62
35662070 2022
20
Impact of etiology leading to abdominoperineal resection with anterolateral thigh flap reconstruction: A retrospective cohort study. 62
36112361 2022
21
Fournier's gangrene in female patient with Turner's syndrome: A case report. 62
35795249 2022
22
Resurfacing of lower extremities: Versatility of thigh flap as pedicle extension graft with consecutive thoracodorsal artery perforator-based flap. 62
36086932 2022
23
The microbiological profile of patients with Fournier's gangrene: A retrospective multi-institutional cohort study. 62
34024222 2022
24
Risk factors for mortality in Fournier's gangrene of anorectal origin. 62
35920430 2022
25
A Rare Case of Post-pubertal Pure Yolk-sac Tumour Incidentally Diagnosed after Surgical Intervention for Fournier's Gangrene. 62
35932138 2022
26
Understanding the Prodrome of Necrotizing Soft Tissue Infections of the Genitalia (Fournier's Gangrene) and the Incidence, Duration, and Risk Factors Associated With Potential Missed Opportunities for an Earlier Diagnosis: A Population-based Longitudinal Study. 62
36006046 2022
27
Favorable Outcomes With Early Component Separation, Primary Closure of Necrotizing Soft Tissue Infections of the Genitalia (Fournier's Gangrene) Debridement Wound Defects. 62
35584736 2022
28
Management of Necrotizing Soft Tissue Infections (Fournier's Gangrene) and Surgical Reconstruction of Debridement Wound Defects. 62
35931437 2022
29
Outcome of necrotizing fasciitis and Fournier's gangrene with and without hyperbaric oxygen therapy: a retrospective analysis over 10 years. 62
35932075 2022
30
An Innovative Technique of Testicular Preservation in Fournier's Gangrene: Surgical Details and Illustration. 62
36059333 2022
31
Fournier's Gangrene: A Coexistence or Consanguinity of SGLT-2 Inhibitor Therapy. 62
36106208 2022
32
Erratum: Factors affecting mortality in Fournier's gangrene: experience of fifty-two patients. 62
36259575 2022
33
Management of Fournier's gangrene during the Covid-19 pandemic era: make a virtue out of necessity. 62
35850577 2022
34
[Fournier's gangrene in an 89-year-old male: An urgent clinical diagnosis]. 62
35760614 2022
35
An Unusual Bacterial Etiology of Fournier's Gangrene in an Immunocompetent Patient. 62
35936142 2022
36
The use of the chimeric conjoint flap technique for complex defects reconstruction throughout the body: Clinical experience with 28 cases. 62
35775973 2022
37
Factors affecting length of stay in Fournier's gangrene: a retrospective analysis of 10 years' data. 62
33086391 2022
38
Reconstruction of the Scrotum With Bilateral Gracilis Muscle Rotational Flaps in a Patient With Acute Myeloid Leukemia Complicated by Fournier's Gangrene. 62
35859983 2022
39
Cutaneous Anomalies of the Critically Ill Patient. 62
35657760 2022
40
Pedicled superficial circumflex iliac artery perforator flap for male genital reconstruction: A case series. 62
35730684 2022
41
Fournier's Gangrene in an HIV-Positive Patient on Empagliflozin for the Treatment of Diabetes Mellitus. 62
35812611 2022
42
Fournier's Gangrene under Sodium-Glucose Cotransporter-2 Inhibitors Therapy in Gynecological Patients. 62
35627798 2022
43
Fournier gangrene with concurrent multifocal necrotizing fasciitis: a systematic review and case report. 62
35615761 2022
44
A rare case of retroperitoneal extension in Fournier's gangrene: A case report and review of literature. 62
35638004 2022
45
Letter to the Editor: Actinomyces turicensis Causing Fournier Gangrene. 62
35394341 2022
46
[Two Cases of Robot-Assisted Total Pelvic Exenteration and Intracorporeal Ileal Conduit for Locally Advanced Rectal Cancer]. 62
35748234 2022
47
The "Sombrero-Shape" Super-Thin Pedicled ALT Flap for Complete Scrotal Reconstruction Following Fournier's Gangrene. 62
35832165 2022
48
[A Case of Fournier's Gangrene during Second-Line IRIS plus Bevacizumab Chemotherapy for Rectal and Anal Canal Cancer]. 62
35578943 2022
49
Fournier's gangrene in an eight-day-old male neonate, a case report. 62
35405509 2022
50
Reconstructive surgery of the scrotum: a systematic review. 62
34635818 2022

Variations for Fournier Gangrene

Expression for Fournier Gangrene

Search GEO for disease gene expression data for Fournier Gangrene.

Pathways for Fournier Gangrene

GO Terms for Fournier Gangrene

Sources for Fournier Gangrene

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 24-Oct-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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