MCID: FRN014
MIFTS: 38

Fournier Gangrene

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Fournier Gangrene

MalaCards integrated aliases for Fournier Gangrene:

Name: Fournier Gangrene 53 72
Fournier's Gangrene 53

Classifications:



External Ids:

UMLS 72 C0238419

Summaries for Fournier Gangrene

NIH Rare Diseases : 53 Fournier gangrene refers to the death of body tissue of the genitals and/or perineum. Signs and symptoms of the condition include genital pain, tenderness, redness, and swelling with a rapid progression to gangrene. Although the condition can affect men and women of all ages, it is most commonly diagnosed in adult males. Most cases of Fournier gangrene are caused by an infection in the genital area or urinary tract. People with impaired immunity (i.e. due to diabetes or HIV) have an increased susceptibility to the condition. Treatment generally includes surgery and medications such as antibiotics and/or antifungal therapy.

MalaCards based summary : Fournier Gangrene, also known as fournier's gangrene, is related to peritonitis and alcoholic hepatitis. An important gene associated with Fournier Gangrene is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Antibodies and Immunoglobulin G have been mentioned in the context of this disorder. Affiliated tissues include skin, prostate and colon, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 75 Fournier gangrene is a type of necrotizing fasciitis or gangrene affecting the external genitalia and/or... more...

Related Diseases for Fournier Gangrene

Diseases related to Fournier Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 342)
# Related Disease Score Top Affiliating Genes
1 peritonitis 30.0 F2 ALB
2 alcoholic hepatitis 29.9 F2 ALB
3 disseminated intravascular coagulation 29.8 SERPINC1 F3 F2
4 thrombophlebitis 29.7 SERPINC1 F8 F2
5 compartment syndrome 29.6 F8 F2 ALB
6 viral hepatitis 29.6 F2 ALB
7 purpura 29.2 SERPINC1 F3 F2
8 liver cirrhosis 28.7 SERPINC1 F3 F2 ALB
9 thrombosis 28.6 SERPINC1 F8 F3 F2
10 vascular disease 28.6 SERPINC1 F3 F2 ALB
11 pulmonary embolism 28.6 SERPINC1 F3 F2 ALB
12 peripheral vascular disease 28.6 SERPINC1 F3 F2 ALB
13 systemic lupus erythematosus 28.5 F3 F2 CD40LG ALB
14 thrombophilia due to thrombin defect 28.5 SERPINC1 F8 F3 F2
15 fasciitis 10.9
16 necrotizing fasciitis 10.9
17 cellulitis 10.6
18 rectum cancer 10.5
19 acute kidney failure 10.4
20 granulocytopenia 10.4
21 alcohol dependence 10.4
22 alcohol use disorder 10.4
23 necrotizing soft tissue infection 10.4
24 acute cystitis 10.3
25 toxic shock syndrome 10.3
26 gas gangrene 10.3
27 acute promyelocytic leukemia 10.3
28 thrombocytopenia 10.3
29 impotence 10.3
30 end stage renal failure 10.3
31 alpha-1-antitrypsin deficiency 10.3 SERPINC1 ALB
32 aleutian mink disease 10.3 CD40LG ALB
33 legg-calve-perthes disease 10.3 SERPINC1 CD40LG
34 thyroid crisis 10.3 F8 ALB
35 spinal cord infarction 10.2 SERPINC1 F2
36 intracranial embolism 10.2 SERPINC1 F2
37 myositis 10.2
38 metabolic acidosis 10.2
39 vasculitis 10.2
40 epididymo-orchitis 10.2
41 hydrocele 10.2
42 alpha-2-plasmin inhibitor deficiency 10.2 SERPINC1 F2
43 prothrombin deficiency, congenital 10.2 SERPINC1 F2
44 pneumocystosis 10.2 CD40LG ALB
45 ischemic colitis 10.2 SERPINC1 F2
46 urethral stricture 10.2
47 rectum adenocarcinoma 10.2
48 diabetes mellitus 10.2
49 spinal cord injury 10.2
50 subendocardial myocardial infarction 10.2 SERPINC1 F2

Graphical network of the top 20 diseases related to Fournier Gangrene:



Diseases related to Fournier Gangrene

Symptoms & Phenotypes for Fournier Gangrene

MGI Mouse Phenotypes related to Fournier Gangrene:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.55 CD40LG F2 F3 F8 SERPINC1
2 homeostasis/metabolism MP:0005376 9.43 ALB CD40LG F2 F3 F8 SERPINC1
3 mortality/aging MP:0010768 9.1 ALB CD40LG F2 F3 F8 SERPINC1

Drugs & Therapeutics for Fournier Gangrene

Drugs for Fournier Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 30)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 2
2 Immunoglobulin G Phase 2
3 Immunologic Factors Phase 2
4 gamma-Globulins Phase 2
5 Immunoglobulins Phase 2
6 Immunoglobulins, Intravenous Phase 2
7 Rho(D) Immune Globulin Phase 2
8
Protein C Approved
9
Daptomycin Approved, Investigational 103060-53-3 16129629
10
Linagliptin Approved 668270-12-0 10096344
11
Metformin Approved 657-24-9 4091 14219
12
Alogliptin Approved 850649-61-5 11450633
13
Saxagliptin Approved 361442-04-8 11243969
14
Vildagliptin Approved, Investigational 274901-16-5 6918537
15
Empagliflozin Approved 864070-44-0
16
Canagliflozin Approved 842133-18-0
17
Zinc Approved, Investigational 7440-66-6 32051
18
2,4-thiazolidinedione Investigational 2295-31-0
19 Anti-Bacterial Agents
20 Anti-Infective Agents
21 HIV Protease Inhibitors
22 insulin
23
protease inhibitors
24 Sitagliptin Phosphate
25 Sodium-Glucose Transporter 2 Inhibitors
26 Glucagon-Like Peptide 1
27 Insulin, Globin Zinc
28 Dipeptidyl-Peptidase IV Inhibitors
29 Hypoglycemic Agents
30 Meglitinide

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Study of AB103 as Compared to Placebo in Patients With Necrotizing Soft Tissue Infections. ACCUTE (AB103 Clinical Composite Endpoint Study in Necrotizing Soft Tissue Infections) Active, not recruiting NCT02469857 Phase 3 AB103 0.5 mg/kg
2 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
3 Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Completed NCT03443544
4 Biomarkers in Necrotizing Soft Tissue Infections - Effects of Hyperbaric Oxygen Treatment on the Immune Response Completed NCT02501382
5 Biomarkers in Necrotizing Soft Tissue Infections - Aspects of the Innate Immune Response Completed NCT02180906
6 ProTreat - Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Completed NCT03147352
7 Raised Serum Lactate as a Marker of Necrotizing Fasciitis; a Consecutive Prospective Review. Completed NCT01739959
8 Open Label, Single Center Study to Evaluate Higher Doses of Daptomycin in the Treatment of Patients With Severe Necrotizing Skin and Soft Tissue Infections. Completed NCT00261807 Daptomycin 6mg/kg/day
9 Safety of Sodium-glucose Cotransporter 2 (SGLT2) Inhibitors Among Patients With Type 2 Diabetes: a Multicenter Cohort Study Active, not recruiting NCT04017221 Sodium-glucose cotransporter 2 (SGLT2) inhibitors;Dipeptidyl peptidase-4 (DPP-4) inhibitors;Other treatment combinations

Search NIH Clinical Center for Fournier Gangrene

Genetic Tests for Fournier Gangrene

Anatomical Context for Fournier Gangrene

MalaCards organs/tissues related to Fournier Gangrene:

41
Skin, Prostate, Colon, Spinal Cord, Testes, Bone, Kidney

Publications for Fournier Gangrene

Articles related to Fournier Gangrene:

(show top 50) (show all 1161)
# Title Authors PMID Year
1
Extensive necrotizing fasciitis from Fournier's gangrene. 38
31236328 2019
2
SGLT2 Inhibitors: A Review of Their Antidiabetic and Cardioprotective Effects. 38
31426529 2019
3
Factors associated with readmission and mortality in adult patients with skin and soft tissue infections. 38
30770547 2019
4
A different perspective for morbidity related to Fournier's gangrene: which scoring system is more reliable to predict requirement of skin graft and flaps in survivors of Fournier's gangrene? 38
31177367 2019
5
Etiology of Fournier gangrene as a prognostic factor in mortality: Analysis of 121 cases. 38
31399259 2019
6
MHRA drug safety update: risk of Fournier's gangrene with SGLT2 inhibitors for diabetes. 38
31345956 2019
7
Self-insertion of an odd urethral foreign body that led to Fournier's gangrene. 38
31413515 2019
8
Incorporating Simplified Fournier's Gangrene Severity Index with early surgical intervention can maximize survival in high-risk Fournier's gangrene patients. 38
31001902 2019
9
Editorial Comment to Incorporating Simplified Fournier's Gangrene Severity Index with early surgical intervention can maximize survival in high-risk Fournier's gangrene patients. 38
31131485 2019
10
Early Presentation of a Rare Complication of Sodium-Glucose Cotransporter-2 Inhibitors 10 Days After Initiation: Case Report and Literature Review. 38
31423402 2019
11
[The nightmare of calciphylaxis]. 38
31344746 2019
12
Image Gallery: Fournier gangrene in a patient with severe hidradenitis suppurativa. 38
31240692 2019
13
Outcomes in patients with Fournier's gangrene originating from the anorectal region with a particular focus on those without perineal involvement. 38
31217986 2019
14
A Reliable Technique in the Reconstruction of Large Penoscrotal Defect: Internal Pudendal Artery Perforator Flap. 38
30880073 2019
15
Rare isolation of Fusobacterium varium from a case of Fournier's gangrene. 38
30951829 2019
16
Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole: Correspondence. 38
30778952 2019
17
Novel Scrotal Reconstruction after Fournier's Gangrene Using the Integra™ Dermal Regeneration Template. 38
30822483 2019
18
Fournier's gangrene and sodium-glucose cotransporter 2 inhibitors: Is there a causal association? 38
30600643 2019
19
Fournier's gangrene in a patient on dapagliflozin treatment for type 2 diabetes. 38
30604507 2019
20
A new technique of scrotoplasty following total scrotal destruction by raised rotated perineal flaps with de epithelialized borders. 38
30178455 2019
21
Fournier's Gangrene: 10-Year Experience of a Plastic Surgery and Burns Department at a Tertiary Hospital. 38
31166897 2019
22
Potential of hyperbaric oxygen in urological diseases. 38
31083787 2019
23
Fournier Gangrene Associated With Sodium-Glucose Cotransporter-2 Inhibitors: A Review of Spontaneous Postmarketing Cases. 38
31060053 2019
24
Scrotal Ultrasound. 38
30928082 2019
25
A fatal case of Fournier's gangrene during neoadjuvant radiotherapy for rectal cancer. 38
30470845 2019
26
An update on the safety of SGLT2 inhibitors. 38
30933547 2019
27
Factors Affecting Mortality Following Necrotizing Soft-Tissue Infections: Randomized Prospective Study. 38
31198277 2019
28
Fournier's gangrene: not as lethal as previously thought? A case series. 38
30173412 2019
29
"Fournier's Gangrene Following Piquerism". 38
31227101 2019
30
Sodium-Glucose Cotransporter 2 Inhibitors and Fournier Gangrene: A Rare and Lethal Adverse Event. 38
30730449 2019
31
Sodium-Glucose Cotransporter 2 Inhibitors and Fournier Gangrene: A Rare and Lethal Adverse Event. 38
30730455 2019
32
Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole. 38
30328081 2019
33
Simultaneous deep inferior epigastric and bilateral anterolateral thigh perforator flap reconstruction of an extended perineoscrotal defect in Fournier's gangrene: A case report. 38
30666712 2019
34
Is the social status a new prognostic factor in the Fournier's gangrene? 38
31131815 2019
35
Sudden unexpected death due to Fournier gangrene. 38
30232701 2019
36
Rectal adenocarcinoma with rectoprostatic fistula following prostate brachytherapy. 38
30936326 2019
37
Fournier's Gangrene With Septic Shock and Multiple Organ Dysfunction Syndrome. 38
30616458 2019
38
Erratum to: Simple scoring system for prediction of mortality in Fournier's gangrene. 38
28894879 2019
39
Minimal invasive laparoscopic harvest of the greater omental flap for Fournier's gangrene scrotal reconstruction. 38
30527712 2019
40
Low thrombin tissue sealant ARTISS (Baxter), in complex primary closure after Fournier's gangrene. 38
30834105 2019
41
Fournier Gangrene: Association of Mortality with the Complete Blood Count Parameters. 38
30516745 2019
42
Reply: Fournier Gangrene: Association of Mortality with the Complete Blood Count Parameters. 38
30516752 2019
43
Predicting Mortality in Fournier Gangrene and Validating the Fournier Gangrene Severity Index: Our Experience with 50 Patients in a Tertiary Care Center in India. 38
30799427 2019
44
REPLY TO THE AUTHORS: Re: Simplified Fournier's gangrene severe index score (SFGSI). 38
30860338 2019
45
Fournier's Gangrene and Sodium-glucose Co-transporter 2(SGLT2) Inhibitors: Our Experience. 38
31016172 2019
46
A Case of Acute Aortoiliac Occlusive Disease Presenting as Cauda Equina Syndrome and Fournier´s Gangrene. 38
31179151 2019
47
Use of Negative Pressure Wound Therapy With Instillation in the Management of Complex Wounds in Critically Ill Patients. 38
30694212 2019
48
Factors Affecting Mortality in Fournier Gangrene: A Single Center Experience. 38
30403562 2019
49
Progress report for intractable ulcer and osteomyelitis cases using autologous micrografts. 38
31105956 2019
50
Recognizing Fournier's Gangrene in the Emergency Department. 38
30702531 2019

Variations for Fournier Gangrene

Expression for Fournier Gangrene

Search GEO for disease gene expression data for Fournier Gangrene.

GO Terms for Fournier Gangrene

Cellular components related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 SERPINC1 F8 F3 F2 CD40LG ALB
2 blood microparticle GO:0072562 9.43 SERPINC1 F2 ALB
3 platelet alpha granule lumen GO:0031093 9.32 F8 ALB
4 endoplasmic reticulum lumen GO:0005788 9.26 SERPINC1 F8 F2 ALB
5 extracellular space GO:0005615 9.1 SERPINC1 F8 F3 F2 CD40LG ALB

Biological processes related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.54 SERPINC1 F2 ALB
2 acute-phase response GO:0006953 9.4 F8 F2
3 platelet activation GO:0030168 9.33 F8 F2 CD40LG
4 blood coagulation, intrinsic pathway GO:0007597 9.32 F8 F2
5 regulation of blood coagulation GO:0030193 9.26 SERPINC1 F2
6 blood coagulation GO:0007596 9.26 SERPINC1 F8 F3 F2
7 hemostasis GO:0007599 8.92 SERPINC1 F8 F3 F2

Molecular functions related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.62 F8 ALB

Sources for Fournier Gangrene

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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