MCID: FRN014
MIFTS: 41

Fournier Gangrene

Categories: Immune diseases, Rare diseases

Aliases & Classifications for Fournier Gangrene

MalaCards integrated aliases for Fournier Gangrene:

Name: Fournier Gangrene 54 74
Fournier's Gangrene 54

Classifications:



External Ids:

UMLS 74 C0238419

Summaries for Fournier Gangrene

NIH Rare Diseases : 54 Fournier gangrene refers to the death of body tissue of the genitals and/or perineum. Signs and symptoms of the condition include genital pain, tenderness, redness, and swelling with a rapid progression to gangrene. Although the condition can affect men and women of all ages, it is most commonly diagnosed in adult males. Most cases of Fournier gangrene are caused by an infection in the genital area or urinary tract. People with impaired immunity (i.e. due to diabetes or HIV) have an increased susceptibility to the condition. Treatment generally includes surgery and medications such as antibiotics and/or antifungal therapy.

MalaCards based summary : Fournier Gangrene, also known as fournier's gangrene, is related to burns and alcoholic hepatitis. An important gene associated with Fournier Gangrene is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include liver, prostate and skin, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 77 Fournier gangrene is a type of necrotizing fasciitis or gangrene affecting the external genitalia and/or... more...

Related Diseases for Fournier Gangrene

Diseases related to Fournier Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 249)
# Related Disease Score Top Affiliating Genes
1 burns 30.3 ALB SERPINC1
2 alcoholic hepatitis 29.9 ALB F2
3 purpura 29.5 F2 F3 SERPINC1
4 thrombosis 29.2 F2 F3 F8 SERPINC1
5 leukemia 10.4
6 fasciitis 10.4
7 necrotizing fasciitis 10.4
8 granulocytopenia 10.3
9 acute promyelocytic leukemia 10.2
10 inguinal hernia 10.2
11 spinal cord injury 10.2
12 rectum cancer 10.2
13 alpha-1-antitrypsin deficiency 10.2 ALB SERPINC1
14 legg-calve-perthes disease 10.2 CD40LG SERPINC1
15 aleutian mink disease 10.2 ALB CD40LG
16 thyroid crisis 10.2 ALB F8
17 spinal cord infarction 10.2 F2 SERPINC1
18 alpha-2-plasmin inhibitor deficiency 10.1 F2 SERPINC1
19 intracranial embolism 10.1 F2 SERPINC1
20 prothrombin deficiency, congenital 10.1 F2 SERPINC1
21 pneumocystosis 10.1 ALB CD40LG
22 ischemic colitis 10.1 F2 SERPINC1
23 subendocardial myocardial infarction 10.1 F2 SERPINC1
24 sneddon syndrome 10.1 F2 SERPINC1
25 squamous cell carcinoma 10.1
26 impotence 10.1
27 orchitis 10.1
28 human immunodeficiency virus infectious disease 10.1
29 appendicitis 10.1
30 epididymo-orchitis 10.1
31 hydrocele 10.1
32 antipyrine metabolism 10.1 ALB F2
33 non-a-e hepatitis 10.1 ALB F2
34 epstein-barr virus hepatitis 10.1 ALB F2
35 retinal vascular occlusion 10.1 F2 SERPINC1
36 anterior spinal artery syndrome 10.1 F2 SERPINC1
37 abdominal tuberculosis 10.1 ALB F2
38 antithrombin iii deficiency 10.1 F2 SERPINC1
39 hepatic tuberculosis 10.1 ALB F2
40 central retinal vein occlusion 10.1 F2 SERPINC1
41 retinal vein occlusion 10.1 F2 SERPINC1
42 severe pre-eclampsia 10.1 ALB SERPINC1
43 kwashiorkor 10.1 ALB F2
44 hepatic coma 10.1 ALB F2
45 infantile liver failure syndrome 1 10.1 ALB F2
46 meningoencephalitis 10.1 ALB CD40LG
47 portal vein thrombosis 10.1 F2 SERPINC1
48 testicular yolk sac tumor 10.1 ALB F8
49 ascending cholangitis 10.1 ALB F2
50 cholangitis 10.1 ALB F2

Graphical network of the top 20 diseases related to Fournier Gangrene:



Diseases related to Fournier Gangrene

Symptoms & Phenotypes for Fournier Gangrene

MGI Mouse Phenotypes related to Fournier Gangrene:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.55 CD40LG F2 F3 F8 SERPINC1
2 homeostasis/metabolism MP:0005376 9.43 ALB CD40LG F2 F3 F8 SERPINC1
3 mortality/aging MP:0010768 9.1 ALB CD40LG F2 F3 F8 SERPINC1

Drugs & Therapeutics for Fournier Gangrene

Drugs for Fournier Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies Phase 2
2 Immunoglobulins Phase 2
3 Rho(D) Immune Globulin Phase 2
4 Immunologic Factors Phase 2
5 Immunoglobulins, Intravenous Phase 2
6 gamma-Globulins Phase 2
7 Immunoglobulin G Phase 2
8
Protein C Approved
9
Daptomycin Approved, Investigational Not Applicable 103060-53-3 16129629
10 Anti-Bacterial Agents Not Applicable
11 Anti-Infective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections Recruiting NCT02469857 Phase 3 AB103 0.5 mg/kg
2 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
3 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
4 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Unknown status NCT03147352
5 Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Completed NCT03443544
6 Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections Completed NCT00261807 Not Applicable Daptomycin 6mg/kg/day
7 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
8 Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing Fasciitis Completed NCT01739959

Search NIH Clinical Center for Fournier Gangrene

Genetic Tests for Fournier Gangrene

Anatomical Context for Fournier Gangrene

MalaCards organs/tissues related to Fournier Gangrene:

42
Liver, Prostate, Skin, Spinal Cord, Myeloid, Bone, Kidney

Publications for Fournier Gangrene

Articles related to Fournier Gangrene:

(show top 50) (show all 713)
# Title Authors Year
1
Fournier's gangrene as an initial manifestation of acute promyelocytic leukemia: A case report and review of the literature. ( 30854206 )
2019
2
Sudden unexpected death due to Fournier gangrene. ( 30232701 )
2019
3
Factors Affecting Mortality in Fournier Gangrene: A Single Center Experience. ( 30403562 )
2019
4
Fournier Gangrene: Association of Mortality with the Complete Blood Count Parameters. ( 30516745 )
2019
5
Reply: Fournier Gangrene: Association of Mortality with the Complete Blood Count Parameters. ( 30516752 )
2019
6
Sodium-Glucose Cotransporter 2 Inhibitors and Fournier Gangrene: A Rare and Lethal Adverse Event. ( 30730449 )
2019
7
Sodium-Glucose Cotransporter 2 Inhibitors and Fournier Gangrene: A Rare and Lethal Adverse Event. ( 30730455 )
2019
8
Predicting Mortality in Fournier Gangrene and Validating the Fournier Gangrene Severity Index: Our Experience with 50 Patients in a Tertiary Care Center in India. ( 30799427 )
2019
9
Fournier Gangrene Associated With Sodium-Glucose Cotransporter-2 Inhibitors: A Review of Spontaneous Postmarketing Cases. ( 31060053 )
2019
10
Fournier's Gangrene and Sodium-glucose Co-transporter 2(SGLT2) Inhibitors: Our Experience. ( 31016172 )
2019
11
A fatal case of Fournier's gangrene during neoadjuvant radiotherapy for rectal cancer. ( 30470845 )
2019
12
Erratum to: Simple scoring system for prediction of mortality in Fournier's gangrene. ( 28894879 )
2019
13
Fournier's gangrene: not as lethal as previously thought? A case series. ( 30173412 )
2019
14
Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole. ( 30328081 )
2019
15
Minimal invasive laparoscopic harvest of the greater omental flap for Fournier's gangrene scrotal reconstruction. ( 30527712 )
2019
16
Fournier's gangrene and sodium-glucose cotransporter 2 inhibitors: Is there a causal association? ( 30600643 )
2019
17
Fournier's gangrene in a patient on dapagliflozin treatment for type 2 diabetes. ( 30604507 )
2019
18
Fournier's Gangrene With Septic Shock and Multiple Organ Dysfunction Syndrome. ( 30616458 )
2019
19
Simultaneous deep inferior epigastric and bilateral anterolateral thigh perforator flap reconstruction of an extended perineoscrotal defect in Fournier's gangrene: A case report. ( 30666712 )
2019
20
Fatal Agranulocytosis and Fournier's Gangrene due to the Use of Metamizole: Correspondence. ( 30778952 )
2019
21
Novel Scrotal Reconstruction after Fournier's Gangrene Using the Integra™ Dermal Regeneration Template. ( 30822483 )
2019
22
Incorporating Simplified Fournier's Gangrene Severity Index with early surgical intervention can maximize survival in high-risk Fournier's gangrene patients. ( 31001902 )
2019
23
Rare isolation of Fusobacterium varium from a case of Fournier's gangrene. ( 30951829 )
2019
24
REPLY TO THE AUTHORS: Re: Simplified Fournier's gangrene severe index score (SFGSI). ( 30860338 )
2019
25
Low thrombin tissue sealant ARTISS (Baxter), in complex primary closure after Fournier's gangrene. ( 30834105 )
2019
26
Management of Fournier's gangrene with skin grafting by bagging technique of testes: case report. ( 30828517 )
2019
27
Recognizing Fournier's Gangrene in the Emergency Department. ( 30702531 )
2019
28
Fournier's Gangrene Masking as Perineal and Scrotal Cellulitis. ( 30041909 )
2018
29
Fournier's gangrene: a rare manifestation of Chikungunya fever. ( 29316869 )
2018
30
Fatal Fournier's gangrene caused by Clostridium ramosum in a patient with central diabetes insipidus and insulin-dependent diabetes mellitus: a case report. ( 30071825 )
2018
31
Acute promyelocytic leukaemia presenting as necrotising fasciitis of the perineum (Fournier gangrene). ( 30567203 )
2018
32
Fournier gangrene: a rare case of necrotizing fasciitis of the entire right hemi-pelvis in a diabetic female. ( 29479450 )
2018
33
Presentation and Diagnosis of Fournier Gangrene. ( 29146218 )
2018
34
Suture Technique to Prevent Air Leakage during Negative-Pressure Wound Therapy in Fournier Gangrene. ( 29464174 )
2018
35
Fournier Gangrene in a patient receiving chemo-radiation for rectal cancer. ( 29507738 )
2018
36
Fournier Gangrene: Association of Mortality with the Complete Blood Count Parameters. ( 29952902 )
2018
37
Preoperative CT Findings and Interobserver Reliability of Fournier Gangrene. ( 30085837 )
2018
38
Fournier gangrene: an historical reappraisal. ( 30182399 )
2018
39
Fournier gangrene due to Rhizobium Radiobacter. ( 30190775 )
2018
40
Fournier gangrene. ( 30192736 )
2018
41
Analysis of prognostic factors affecting poor outcomes in 41 cases of Fournier gangrene. ( 30505824 )
2018
42
Fournier's gangrene caused by penetration of a rectal cancer followed by neoadjuvant chemotherapy. ( 30259251 )
2018
43
Sacral Pressure Ulcer-induced Fournier's Gangrene Extending to the Retroperitoneum: A Case Report. ( 29406297 )
2018
44
Fournier's gangrene caused by Streptococcus anginosus, a rare etiologic agent. ( 28676193 )
2018
45
Risk factors for mortality in fournier's gangrene in a general hospital: use of simplified founier gangrene severe index score (SFGSI). ( 28853819 )
2018
46
Emergence of multi-drug resistant organisms (MDROs) causing Fournier's gangrene. ( 28962969 )
2018
47
Re: Simplified Fournier's gangrene severe index score (SFGSI). ( 29135415 )
2018
48
Use of photodynamic inactivation for in vitro reduction of prevalent bacteria in Fournier's Gangrene. ( 29219279 )
2018
49
Surviving Fournier's gangrene: Multivariable analysis and a novel scoring system to predict length of stay. ( 29284566 )
2018
50
Fournier's Gangrene: Clinical Presentation of 13 Cases. ( 29374769 )
2018

Variations for Fournier Gangrene

Expression for Fournier Gangrene

Search GEO for disease gene expression data for Fournier Gangrene.

GO Terms for Fournier Gangrene

Cellular components related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 ALB CD40LG F2 F3 F8 SERPINC1
2 blood microparticle GO:0072562 9.43 ALB F2 SERPINC1
3 platelet alpha granule lumen GO:0031093 9.32 ALB F8
4 endoplasmic reticulum lumen GO:0005788 9.26 ALB F2 F8 SERPINC1
5 extracellular space GO:0005615 9.1 ALB CD40LG F2 F3 F8 SERPINC1

Biological processes related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.54 ALB F2 SERPINC1
2 acute-phase response GO:0006953 9.4 F2 F8
3 platelet activation GO:0030168 9.33 CD40LG F2 F8
4 blood coagulation, intrinsic pathway GO:0007597 9.32 F2 F8
5 regulation of blood coagulation GO:0030193 9.26 F2 SERPINC1
6 blood coagulation GO:0007596 9.26 F2 F3 F8 SERPINC1
7 hemostasis GO:0007599 8.92 F2 F3 F8 SERPINC1

Molecular functions related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.62 ALB F8

Sources for Fournier Gangrene

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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