Aliases & Classifications for Fournier Gangrene

MalaCards integrated aliases for Fournier Gangrene:

Name: Fournier Gangrene 53 73
Fournier's Gangrene 53

Classifications:



External Ids:

UMLS 73 C0238419

Summaries for Fournier Gangrene

NIH Rare Diseases : 53 Fournier gangrene refers to the death of body tissue of the genitals and/or perineum. Signs and symptoms of the condition include genital pain, tenderness, redness, and swelling with a rapid progression to gangrene. Although the condition can affect men and women of all ages, it is most commonly diagnosed in adult males. Most cases of Fournier gangrene are caused by an infection in the genital area or urinary tract. People with impaired immunity (i.e. due to diabetes or HIV) have an increased susceptibility to the condition. Treatment generally includes surgery and medications such as antibiotics and/or antifungal therapy.

MalaCards based summary : Fournier Gangrene, also known as fournier's gangrene, is related to peritonitis and thrombosis. An important gene associated with Fournier Gangrene is SERPINC1 (Serpin Family C Member 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Collagen chain trimerization. The drugs Rho(D) Immune Globulin and gamma-Globulins have been mentioned in the context of this disorder. Affiliated tissues include skin, spinal cord and appendix, and related phenotypes are homeostasis/metabolism and mortality/aging

Wikipedia : 76 Fournier gangrene is a type of necrotizing fasciitis or gangrene affecting the external genitalia and/or... more...

Related Diseases for Fournier Gangrene

Diseases related to Fournier Gangrene via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 215)
# Related Disease Score Top Affiliating Genes
1 peritonitis 29.9 ALB F2
2 thrombosis 29.5 F2 F3 SERPINC1
3 spinal cord infarction 10.5 F2 SERPINC1
4 sudden sensorineural hearing loss 10.5 F2 SERPINC1
5 blood protein disease 10.5 F2 SERPINC1
6 alpha-2-plasmin inhibitor deficiency 10.5 F2 SERPINC1
7 prothrombin deficiency, congenital 10.5 F2 SERPINC1
8 ischemic colitis 10.5 F2 SERPINC1
9 anterior spinal artery syndrome 10.5 F2 SERPINC1
10 subendocardial myocardial infarction 10.5 F2 SERPINC1
11 sneddon syndrome 10.5 F2 SERPINC1
12 retinal vascular occlusion 10.5 F2 SERPINC1
13 antithrombin iii deficiency 10.5 F2 SERPINC1
14 central retinal vein occlusion 10.5 F2 SERPINC1
15 syphilitic meningitis 10.5 CD40LG SERPINC1
16 portal vein thrombosis 10.5 F2 SERPINC1
17 patent foramen ovale 10.5 F2 SERPINC1
18 burns 10.5 ALB SERPINC1
19 japanese spotted fever 10.4 CD40LG SERPINC1
20 placental abruption 10.4 F2 SERPINC1
21 protein c deficiency 10.4 F2 SERPINC1
22 antipyrine metabolism 10.4 ALB F2
23 non-a-e hepatitis 10.4 ALB F2
24 ischemic optic neuropathy 10.4 F2 SERPINC1
25 retinal vein occlusion 10.4 F2 SERPINC1
26 livedoid vasculopathy 10.4 CD40LG F2
27 abdominal tuberculosis 10.4 ALB F2
28 legg-calve-perthes disease 10.4 CD40LG SERPINC1
29 nonarteritic anterior ischemic optic neuropathy 10.4 F2 SERPINC1
30 kwashiorkor 10.4 ALB F2
31 hepatic tuberculosis 10.4 ALB F2
32 hepatic coma 10.4 ALB F2
33 hepatitis d 10.4 CD40LG F2
34 ascending cholangitis 10.4 ALB F2
35 alpha-1-antitrypsin deficiency 10.4 ALB SERPINC1
36 osteonecrosis 10.3 F2 SERPINC1
37 choledocholithiasis 10.3 ALB F2
38 colorado tick fever 10.3 ALB CD40LG
39 cork-handlers' disease 10.3 ALB CD40LG
40 pulmonary edema 10.3 F2 SERPINC1
41 plasmodium malariae malaria 10.3 ALB CD40LG
42 hepatorenal syndrome 10.3 ALB F2
43 acute liver failure 10.3 ALB F2
44 yellow nail syndrome 10.3 ALB CD40LG
45 angina pectoris 10.3 F3 SERPINC1
46 diffuse glomerulonephritis 10.3 ALB CD40LG
47 aleutian mink disease 10.3 ALB CD40LG
48 cerebral falx meningioma 10.3 F2 F3
49 non-secretory myeloma 10.3 ALB CD40LG
50 varicose veins 10.3 F2 SERPINC1

Graphical network of the top 20 diseases related to Fournier Gangrene:



Diseases related to Fournier Gangrene

Symptoms & Phenotypes for Fournier Gangrene

MGI Mouse Phenotypes related to Fournier Gangrene:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.43 ALB CD40LG F2 F3 F8 SERPINC1
2 mortality/aging MP:0010768 9.1 ALB CD40LG F2 F3 F8 SERPINC1

Drugs & Therapeutics for Fournier Gangrene

Drugs for Fournier Gangrene (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 10)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Rho(D) Immune Globulin Phase 2
2 gamma-Globulins Phase 2
3 Immunoglobulin G Phase 2
4 Antibodies Phase 2
5 Immunoglobulins Phase 2
6 Immunoglobulins, Intravenous Phase 2
7
Daptomycin Approved, Investigational Not Applicable 103060-53-3 16129629
8
Protein C Approved
9 Anti-Bacterial Agents Not Applicable
10 Anti-Infective Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Efficacy and Safety Study of AB103 in the Treatment of Patients With Necrotizing Soft Tissue Infections Recruiting NCT02469857 Phase 3 AB103 0.5 mg/kg
2 Immunoglobulin for Necrotizing Soft Tissue Infections: a Randomised Controlled Trial Completed NCT02111161 Phase 2 IVIG (Privigen);Saline 0.9%
3 Modulation of Biomarkers in Patients With Flesh-eating Bacterial Infections After With Hyperbaric Oxygen Treatment Unknown status NCT02501382
4 Fournier's Gangrene and the Origin of the Infection as a Prognostic of Morbidity and Mortality, an Analysis of 121 Patients Completed NCT03443544
5 Daptomycin for the Treatment of Severe Necrotizing Soft-Tissue Infections Completed NCT00261807 Not Applicable Daptomycin 6mg/kg/day
6 Biomarkers in Patients With Flesh-eating Bacterial Infections Completed NCT02180906
7 Exploratory Study of Raised Serum Lactate as a Marker of Necrotizing Fasciitis Completed NCT01739959
8 Prognosis and Treatment of Necrotizing Soft Tissue Infections: A Prospective Cohort Study Recruiting NCT03147352

Search NIH Clinical Center for Fournier Gangrene

Genetic Tests for Fournier Gangrene

Anatomical Context for Fournier Gangrene

MalaCards organs/tissues related to Fournier Gangrene:

41
Skin, Spinal Cord, Appendix, Testes, Prostate, Colon

Publications for Fournier Gangrene

Articles related to Fournier Gangrene:

(show top 50) (show all 83)
# Title Authors Year
1
Fournier Gangrene in a patient receiving chemo-radiation for rectal cancer. ( 29507738 )
2018
2
Fournier Gangrene: Association of Mortality with the Complete Blood Count Parameters. ( 29952902 )
2018
3
Suture Technique to Prevent Air Leakage during Negative-Pressure Wound Therapy in Fournier Gangrene. ( 29464174 )
2018
4
Fournier gangrene: a rare case of necrotizing fasciitis of the entire right hemi-pelvis in a diabetic female. ( 29479450 )
2018
5
A fascia lata free flap in pelvic exenteration for Fournier gangrene due to advanced rectal cancer: a case report. ( 28550641 )
2017
6
Using negative pressure therapy for improving skin graft taking on genital area defects following Fournier gangrene. ( 28861313 )
2017
7
Presentation and Diagnosis of Fournier Gangrene. ( 29146218 )
2017
8
Bilateral femoral posterior neurocutaneous perforater flap successfully treating Fournier gangrene: A case report. ( 29145312 )
2017
9
Lethal Fournier gangrene following cardiac surgery with cardiopulmonary bypass. ( 27986558 )
2017
10
Evaluation of LRINEC Scale Feasibility for Predicting Outcomes of Fournier Gangrene. ( 27023717 )
2016
11
Deep tissue infection of the perineum: Case report and literature review of Fournier gangrene. ( 27255622 )
2016
12
Is hemoglobin A1c level effective in predicting the prognosis of Fournier gangrene? ( 27453658 )
2016
13
Fournier Gangrene Caused by Candida albicans in an Infant After Cardiac Surgery. ( 27807668 )
2016
14
Simplified Penoscrotal Reconstruction for Extensive Fournier Gangrene Defects. ( 27928816 )
2016
15
Reconstruction of Defects After Fournier Gangrene: A Systematic Review. ( 26171090 )
2015
16
Fournier gangrene with extensive necrosis of urethra and bladder mucosa: A rare occurrence in a patient with advanced prostate cancer. ( 26692675 )
2015
17
Negative pressure wound therapy applied before and after split-thickness skin graft helps healing of Fournier gangrene: a case report (CARE-Compliant). ( 25654376 )
2015
18
Fournier gangrene: rare complication of rectal cancer. ( 26161211 )
2015
19
Comparison of Diverting Colostomy and Bowel Management Catheter Applications in Fournier Gangrene Cases Requiring Fecal Diversion. ( 26730041 )
2015
20
Unusual foreign body in the sigmoid colon, chronic alcohol abuse, and Fournier gangrene: a case report. ( 25878494 )
2015
21
A Contemporary Analysis of Fournier Gangrene Using the National Surgical Quality Improvement Program. ( 25770725 )
2015
22
Fournier gangrene. ( 25838914 )
2015
23
Fournier Gangrene in Pregnancy. ( 25774932 )
2015
24
Xenogenic (porcine) acellular dermal matrix promotes growth of granulation tissues in the wound healing of Fournier gangrene. ( 25569072 )
2015
25
Temporary Relocation of the Testes in Anteromedial Thigh Pouches Facilitates Delayed Primary Scrotal Wound Closure in Fournier Gangrene With Extensive Loss of Scrotal Skin-Experience With 12 Cases. ( 25785387 )
2015
26
Enterostomy can decrease the mortality of patients with Fournier gangrene. ( 24976731 )
2014
27
Emergence of Antibiotic-Resistant Bacteria in Patients with Fournier Gangrene. ( 25215467 )
2014
28
Solitary Candida albicans Infection Causing Fournier Gangrene and Review of Fungal Etiologies. ( 25009452 )
2014
29
Bilateral Necrotizing Fasciitis around the Hips Differentiated from Fournier Gangrene: A Case Report. ( 27536594 )
2014
30
Favorable outcome of Fournier gangrene in two patients with diabetes mellitus on continuous peritoneal dialysis. ( 25338433 )
2014
31
Bilateral adrenal haemorrhage associated with heparin-induced thrombocytopaenia during treatment of Fournier gangrene. ( 25315802 )
2014
32
FDG PET/CT Images Demonstrating Fournier Gangrene With Bilateral Pelvic Muscle Extension in a Patient With Recurrent Rectosigmoid Cancer. ( 23510891 )
2014
33
Fournier gangrene from a thirty-two-centimeter rectosigmoid foreign body. ( 23200766 )
2013
34
Fournier gangrene: an unusual presentation involving the bulbous urethra and forming free gas in the urinary bladder. ( 21820264 )
2013
35
Abdominal implantation of testicles in the management of intractable testicular pain in fournier gangrene. ( 24229025 )
2013
36
Fournier gangrene as a manifestation of undiagnosed metastatic perforated colorectal cancer. ( 23438275 )
2013
37
Emergency radiology eponyms: part 2--Naclerio's V sign to Fournier gangrene. ( 23065070 )
2013
38
2-octyl-cyanoacrylate glue for fixation of STSG in genitourinary tissue defects due to Fournier gangrene: a preliminary trial. ( 23720107 )
2013
39
Fournier gangrene: description of 37 cases and analysis of associated health care costs. ( 22445562 )
2012
40
Fournier gangrene and unexpected death. ( 22471925 )
2012
41
Prognostic factors in Fournier gangrene. ( 22726562 )
2012
42
A clinical case of Fournier gangrene. ( 23025122 )
2012
43
Fournier gangrene: first manifestation of occult rectal cancer. ( 22191139 )
2011
44
Neonatal scrotal wall necrotizing fasciitis (Fournier gangrene): a case report. ( 22151925 )
2011
45
The emergency computed tomography as important modality for early diagnosis of Fournier gangrene. ( 20951534 )
2011
46
Is intensive multimodality therapy the best treatment for fournier gangrene? Evaluation of clinical outcome and survival rate of 41 patients. ( 21943303 )
2011
47
Fournier gangrene: our approach and patients. ( 21849758 )
2011
48
F-18 fluorodeoxyglucose PET in Fournier gangrene. ( 20631519 )
2010
49
Fournier gangrene: a review of 41 patients and strategies for reconstruction. ( 20407363 )
2010
50
Fournier gangrene. ( 20411094 )
2010

Variations for Fournier Gangrene

Expression for Fournier Gangrene

Search GEO for disease gene expression data for Fournier Gangrene.

GO Terms for Fournier Gangrene

Cellular components related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.63 ALB CD40LG F2 F3 F8 SERPINC1
2 blood microparticle GO:0072562 9.43 ALB F2 SERPINC1
3 platelet alpha granule lumen GO:0031093 9.32 ALB F8
4 endoplasmic reticulum lumen GO:0005788 9.26 ALB F2 F8 SERPINC1
5 extracellular space GO:0005615 9.1 ALB CD40LG F2 F3 F8 SERPINC1

Biological processes related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular protein metabolic process GO:0044267 9.54 ALB F2 SERPINC1
2 acute-phase response GO:0006953 9.4 F2 F8
3 platelet activation GO:0030168 9.33 CD40LG F2 F8
4 blood coagulation, intrinsic pathway GO:0007597 9.32 F2 F8
5 regulation of blood coagulation GO:0030193 9.26 F2 SERPINC1
6 blood coagulation GO:0007596 9.26 F2 F3 F8 SERPINC1
7 hemostasis GO:0007599 8.92 F2 F3 F8 SERPINC1

Molecular functions related to Fournier Gangrene according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 copper ion binding GO:0005507 8.62 ALB F8

Sources for Fournier Gangrene

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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