MCID: FRT001
MIFTS: 32

Fourth Cranial Nerve Palsy

Categories: Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Fourth Cranial Nerve Palsy

MalaCards integrated aliases for Fourth Cranial Nerve Palsy:

Name: Fourth Cranial Nerve Palsy 12 15
Fourth or Trochlear Nerve Palsy 12
Fourth Cranial Nerve Paresis 74
Fourth Nerve Palsy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10869
ICD10 34 H49.1
UMLS 74 C0271375

Summaries for Fourth Cranial Nerve Palsy

MalaCards based summary : Fourth Cranial Nerve Palsy, also known as fourth or trochlear nerve palsy, is related to fourth cranial nerve palsy, familial congenital and congenital trochlear nerve palsy. An important gene associated with Fourth Cranial Nerve Palsy is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are CCR5 Pathway in Macrophages and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. Affiliated tissues include eye and pituitary.

Wikipedia : 77 Fourth cranial nerve palsy also known as Trochlear nerve palsy, is a condition affecting Cranial Nerve 4... more...

Related Diseases for Fourth Cranial Nerve Palsy

Graphical network of the top 20 diseases related to Fourth Cranial Nerve Palsy:



Diseases related to Fourth Cranial Nerve Palsy

Symptoms & Phenotypes for Fourth Cranial Nerve Palsy

Drugs & Therapeutics for Fourth Cranial Nerve Palsy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355
2 Measuring Cyclotorsion on Scanning Laser Ophthalmoscopy (SLO)-Fundus Photographs Completed NCT02631369 Not Applicable
3 Effects of Ocular Electroacupuncture on Trochlear Nerve Palsy Recruiting NCT03099473 Not Applicable
4 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
5 A Retrospective Study of the Effects of Ocular Acupuncture on Ocular Motor Nerve Palsy Not yet recruiting NCT03461809

Search NIH Clinical Center for Fourth Cranial Nerve Palsy

Genetic Tests for Fourth Cranial Nerve Palsy

Anatomical Context for Fourth Cranial Nerve Palsy

MalaCards organs/tissues related to Fourth Cranial Nerve Palsy:

42
Eye, Pituitary

Publications for Fourth Cranial Nerve Palsy

Articles related to Fourth Cranial Nerve Palsy:

(show all 14)
# Title Authors Year
1
Incidence and Etiology of Presumed Fourth Cranial Nerve Palsy: A Population-based Study. ( 29102606 )
2018
2
Isolated fourth cranial nerve palsy due to pituitary macroadenoma. ( 28050074 )
2016
3
Cyclotropia to differentiate longstanding and acute fourth cranial nerve palsy. ( 25313119 )
2014
4
Fourth cranial nerve palsy and bilateral acute retinal necrosis following human herpesvirus 6 infection of the central nervous system. ( 24328436 )
2014
5
Management of congenital fourth cranial nerve palsy. ( 24661367 )
2014
6
Fourth cranial nerve palsy and Brown syndrome: two interrelated congenital cranial dysinnervation disorders? ( 23636931 )
2013
7
Germinoma presenting as a fourth cranial nerve palsy in a patient with adenomatous polyposis coli (APC) gene mutation. ( 21315632 )
2011
8
CT demonstration of dorsal midbrain hemorrhage in traumatic fourth cranial nerve palsy. ( 20182210 )
2010
9
Fourth cranial nerve palsy in a collegiate lacrosse player: a case report. ( 20617917 )
2010
10
Painful fourth cranial nerve palsy caused by posteriorly-draining dural carotid-cavernous sinus fistula. ( 11000739 )
2000
11
Fourth cranial nerve palsy in pediatric patients with pseudotumor cerebri. ( 10030583 )
1999
12
Transitory fourth cranial nerve palsy due to foramen ovale electrode placement. ( 9309297 )
1997
13
Fourth cranial nerve palsy following spinal anesthesia. A case report. ( 2952674 )
1987
14
Familial congenital fourth cranial nerve palsy. ( 3985833 )
1985

Variations for Fourth Cranial Nerve Palsy

Expression for Fourth Cranial Nerve Palsy

Search GEO for disease gene expression data for Fourth Cranial Nerve Palsy.

Pathways for Fourth Cranial Nerve Palsy

Pathways related to Fourth Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.19 HCK PF4 PPBP
2
Show member pathways
11.39 PF4 PPBP
3 10.89 APC PRNP
4 10.65 HCK PRL
5 10.04 HCK PRNP

GO Terms for Fourth Cranial Nerve Palsy

Cellular components related to Fourth Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.62 PF4 PPBP

Biological processes related to Fourth Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.54 PF4 PPBP PRL
2 negative regulation of angiogenesis GO:0016525 9.43 PF4 PRL
3 neutrophil chemotaxis GO:0030593 9.4 PF4 PPBP
4 inflammatory response GO:0006954 9.33 HCK PF4 PPBP
5 chemokine-mediated signaling pathway GO:0070098 9.32 PF4 PPBP
6 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.26 PF4 PPBP
7 positive regulation of cell death GO:0010942 8.96 APC PRNP
8 leukocyte chemotaxis GO:0030595 8.62 PF4 PPBP

Molecular functions related to Fourth Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.62 PF4 PPBP

Sources for Fourth Cranial Nerve Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....