MCID: FRT001
MIFTS: 26

Fourth Cranial Nerve Palsy

Categories: Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Fourth Cranial Nerve Palsy

MalaCards integrated aliases for Fourth Cranial Nerve Palsy:

Name: Fourth Cranial Nerve Palsy 12 15
Fourth or Trochlear Nerve Palsy 12
Fourth Cranial Nerve Paresis 71
Fourth Nerve Palsy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10869
ICD10 32 H49.1
UMLS 71 C0271375

Summaries for Fourth Cranial Nerve Palsy

MalaCards based summary : Fourth Cranial Nerve Palsy, also known as fourth or trochlear nerve palsy, is related to hypertropia and exotropia. An important gene associated with Fourth Cranial Nerve Palsy is APC (APC Regulator Of WNT Signaling Pathway). Affiliated tissues include eye, pituitary and pineal.

Wikipedia : 74 Fourth cranial nerve palsy, is a condition affecting cranial nerve 4 (IV), the trochlear nerve, which is... more...

Related Diseases for Fourth Cranial Nerve Palsy

Diseases in the Fourth Cranial Nerve Palsy family:

Fourth Cranial Nerve Palsy, Familial Congenital

Diseases related to Fourth Cranial Nerve Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 61)
# Related Disease Score Top Affiliating Genes
1 hypertropia 30.4 SEMA7A DPT
2 exotropia 30.4 SEMA7A DPT
3 esotropia 30.2 SEMA7A DPT
4 pulmonary embolism 28.8 PF4 AVP
5 fourth cranial nerve palsy, familial congenital 13.0
6 congenital trochlear nerve palsy 12.0
7 cranial nerve palsy 10.6
8 hydrocephalus 10.2
9 strabismus 10.2
10 alternating exotropia 10.2
11 mechanical strabismus 10.2
12 monocular esotropia 10.1
13 pfeiffer syndrome 10.0
14 duane retraction syndrome 1 10.0
15 intracranial hypertension, idiopathic 10.0
16 brown syndrome 10.0
17 familial adenomatous polyposis 10.0
18 duane retraction syndrome 10.0
19 germinoma 10.0
20 herpes simplex 10.0
21 chickenpox 10.0
22 exophthalmos 10.0
23 intracranial hypertension 10.0
24 cyclotropia 10.0
25 isolated duane retraction syndrome 10.0
26 traumatic brain injury 10.0
27 neurofibromatosis, type ii 9.9
28 polykaryocytosis inducer 9.9
29 temporal arteritis 9.9
30 torticollis 9.9
31 human granulocytic anaplasmosis 9.9
32 human monocytic ehrlichiosis 9.9
33 benign teratoma 9.9
34 ehrlichiosis 9.9
35 suppression amblyopia 9.9
36 amblyopia 9.9
37 lemierre's syndrome 9.9
38 horner's syndrome 9.9
39 papilledema 9.9
40 melanoma 9.9
41 cystic teratoma 9.9
42 antiphospholipid syndrome 9.9
43 pituitary adenoma 9.9
44 thrombophlebitis 9.9
45 mature teratoma 9.9
46 adenoma 9.9
47 meningitis 9.9
48 pathologic nystagmus 9.9
49 trochleitis 9.9
50 tuberculous meningitis 9.9

Graphical network of the top 20 diseases related to Fourth Cranial Nerve Palsy:



Diseases related to Fourth Cranial Nerve Palsy

Symptoms & Phenotypes for Fourth Cranial Nerve Palsy

Drugs & Therapeutics for Fourth Cranial Nerve Palsy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355

Search NIH Clinical Center for Fourth Cranial Nerve Palsy

Genetic Tests for Fourth Cranial Nerve Palsy

Anatomical Context for Fourth Cranial Nerve Palsy

MalaCards organs/tissues related to Fourth Cranial Nerve Palsy:

40
Eye, Pituitary, Pineal, Brain, Monocytes

Publications for Fourth Cranial Nerve Palsy

Articles related to Fourth Cranial Nerve Palsy:

(show all 46)
# Title Authors PMID Year
1
Clinical outcomes and aetiology of fourth cranial nerve palsy with acute vertical diplopia in adults. 61
31932705 2020
2
Cause of acquired onset of diplopia due to isolated third, fourth, and sixth cranial nerve palsies in patients aged 20 to 50 years in Korea: A high resolution magnetic resonance imaging study. 61
31669731 2019
3
A case of bilateral fourth nerve palsy associated with pseudotumor cerebri syndrome. 61
31038553 2019
4
Acquired onset of third, fourth, and sixth cranial nerve palsies in children and adolescents. 61
30760897 2019
5
Ocular Misalignment in Dizzy Patients-Something's A-Skew. 61
30883490 2019
6
Incidence and Etiology of Presumed Fourth Cranial Nerve Palsy: A Population-based Study. 61
29102606 2018
7
Pituitary Apoplexy Presenting as Ophthalmoplegia and Altered Level of Consciousness without Headache. 61
29854489 2018
8
Ocular Causes of Abnormal Head Position: Strabismus Clinic Data. 61
28845325 2017
9
Isolated fourth cranial nerve palsy due to pituitary macroadenoma. 61
28050074 2016
10
The Development of Hypertrophic Inferior Olivary Nucleus in Oculopalatal Tremor. 61
27928422 2016
11
Fourth cranial nerve palsy and bilateral acute retinal necrosis following human herpesvirus 6 infection of the central nervous system. 61
24328436 2014
12
Management of congenital fourth cranial nerve palsy. 61
24661367 2014
13
Cyclotropia to differentiate longstanding and acute fourth cranial nerve palsy. 61
25313119 2014
14
Persistent diplopia and superior oblique muscle dysfunction following dissection of the orbital periosteum in cranial base surgery. 61
23913249 2013
15
Fourth cranial nerve palsy and Brown syndrome: two interrelated congenital cranial dysinnervation disorders? 61
23636931 2013
16
Varicella zoster virus infection presenting as isolated diplopia: a case report. 61
23497310 2013
17
Radiation-induced ocular motor cranial nerve palsies in patients with pituitary tumor. 61
21857187 2011
18
Germinoma presenting as a fourth cranial nerve palsy in a patient with adenomatous polyposis coli (APC) gene mutation. 61
21315632 2011
19
Attention deficit hyperactivity disorder: diagnosis and treatment masking the ophthalmic clinical presentation of a pineal gland tumour in a teenager. 61
20225001 2010
20
Fourth cranial nerve palsy in a collegiate lacrosse player: a case report. 61
20617917 2010
21
An unusual collision tumor comprising a prolactinoma and a plasmocytoma originating from the sellar region. 61
18846427 2010
22
Effect of ocular torsion on A and V patterns and apparent oblique muscle overaction. 61
20547948 2010
23
CT demonstration of dorsal midbrain hemorrhage in traumatic fourth cranial nerve palsy. 61
20182210 2010
24
Stereotactic radiosurgery in two cases of presumed fourth cranial nerve schwannoma. 61
19458578 2009
25
Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Case report. 61
17330542 2007
26
Incidence and types of childhood hypertropia: a population-based study. 61
16647125 2006
27
A case of PHACE syndrome. 61
16197426 2005
28
Bilateral fourth-nerve palsy occurring after shaking injury in infancy. 61
15226732 2004
29
[Strabismus surgery of the myopic patient under topical anaesthesia]. 61
14648370 2003
30
Quantitative changes in the field of binocular single vision following a fadenoperation to a vertical rectus muscle. 61
12381988 2002
31
Superior oblique palsy in a patient with a history of perineural spread from a periorbital squamous cell carcinoma. 61
11130747 2000
32
Painful fourth cranial nerve palsy caused by posteriorly-draining dural carotid-cavernous sinus fistula. 61
11000739 2000
33
Clinical diversity of hereditary Duane's retraction syndrome. 61
10711888 2000
34
Fourth cranial nerve palsy in pediatric patients with pseudotumor cerebri. 61
10030583 1999
35
Schwannoma in patients with isolated unilateral trochlear nerve palsy. 61
10030561 1999
36
Transitory fourth cranial nerve palsy due to foramen ovale electrode placement. 61
9309297 1997
37
Diplopia following head injury. 61
2276794 1990
38
Bilateral ophthalmoplegia during percutaneous transluminal coronary angioplasty. 61
2361198 1990
39
Left trochlear nerve palsy, unique symptom of an arachnoid cyst of the quadrigeminal plate. Case report. 61
2275426 1990
40
Congenital fourth nerve palsy and occult cranium bifidum. 61
3242538 1988
41
Fourth cranial nerve palsy following spinal anesthesia. A case report. 61
2952674 1987
42
Traumatic trochlear-nerve palsy due to haematoma. 61
3758505 1986
43
Primary-position hypotropia after anterior transposition of the inferior oblique. 61
3947298 1986
44
Familial congenital superior oblique palsy. 61
3951819 1986
45
Familial congenital fourth cranial nerve palsy. 61
3985833 1985
46
Ocular myasthenia presenting as superior oblique weakness. 61
6226695 1982

Variations for Fourth Cranial Nerve Palsy

Expression for Fourth Cranial Nerve Palsy

Search GEO for disease gene expression data for Fourth Cranial Nerve Palsy.

Pathways for Fourth Cranial Nerve Palsy

GO Terms for Fourth Cranial Nerve Palsy

Cellular components related to Fourth Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 9.16 PPBP PF4
2 collagen-containing extracellular matrix GO:0062023 9.13 SEMA7A PF4 DPT
3 extracellular space GO:0005615 9.02 SEMA7A PPBP PF4 DPT AVP

Biological processes related to Fourth Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.54 SEMA7A PPBP PF4
2 neutrophil chemotaxis GO:0030593 9.32 PPBP PF4
3 chemokine-mediated signaling pathway GO:0070098 9.26 PPBP PF4
4 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.16 PPBP PF4
5 inflammatory response GO:0006954 9.13 SEMA7A PPBP PF4
6 leukocyte chemotaxis GO:0030595 8.62 PPBP PF4

Molecular functions related to Fourth Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.62 PPBP PF4

Sources for Fourth Cranial Nerve Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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