MCID: FRT001
MIFTS: 29

Fourth Cranial Nerve Palsy

Categories: Eye diseases, Genetic diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Fourth Cranial Nerve Palsy

MalaCards integrated aliases for Fourth Cranial Nerve Palsy:

Name: Fourth Cranial Nerve Palsy 12 15
Fourth or Trochlear Nerve Palsy 12
Fourth Cranial Nerve Paresis 72
Fourth Nerve Palsy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10869
ICD10 33 H49.1
UMLS 72 C0271375

Summaries for Fourth Cranial Nerve Palsy

MalaCards based summary : Fourth Cranial Nerve Palsy, also known as fourth or trochlear nerve palsy, is related to fourth cranial nerve palsy, familial congenital and congenital trochlear nerve palsy. An important gene associated with Fourth Cranial Nerve Palsy is APC (APC Regulator Of WNT Signaling Pathway), and among its related pathways/superpathways are CCR5 Pathway in Macrophages and Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions. Affiliated tissues include eye, pituitary and pineal.

Wikipedia : 75 Fourth cranial nerve palsy, is a condition affecting cranial nerve 4 (IV), the trochlear nerve, which is... more...

Related Diseases for Fourth Cranial Nerve Palsy

Diseases in the Fourth Cranial Nerve Palsy family:

Fourth Cranial Nerve Palsy, Familial Congenital

Diseases related to Fourth Cranial Nerve Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 58)
# Related Disease Score Top Affiliating Genes
1 fourth cranial nerve palsy, familial congenital 13.0
2 congenital trochlear nerve palsy 12.0
3 cranial nerve palsy 10.6
4 hydrocephalus 10.2
5 hypertropia 10.2
6 congenital hydrocephalus 10.2
7 strabismus 10.1
8 alternating exotropia 10.1
9 exotropia 10.1
10 mechanical strabismus 10.1
11 monocular esotropia 10.1
12 esotropia 10.1
13 pfeiffer syndrome 10.0
14 duane retraction syndrome 1 10.0
15 intracranial hypertension, idiopathic 10.0
16 brown syndrome 10.0
17 familial adenomatous polyposis 10.0
18 duane retraction syndrome 10.0
19 germinoma 10.0
20 herpes simplex 10.0
21 chickenpox 10.0
22 exophthalmos 10.0
23 intracranial hypertension 10.0
24 cyclotropia 10.0
25 isolated duane retraction syndrome 10.0
26 traumatic brain injury 10.0
27 neurofibromatosis, type ii 9.9
28 polykaryocytosis inducer 9.9
29 temporal arteritis 9.9
30 torticollis 9.9
31 human granulocytic anaplasmosis 9.9
32 human monocytic ehrlichiosis 9.9
33 ehrlichiosis 9.9
34 suppression amblyopia 9.9
35 amblyopia 9.9
36 lemierre's syndrome 9.9
37 horner's syndrome 9.9
38 papilledema 9.9
39 dermoid cyst 9.9
40 cystic teratoma 9.9
41 antiphospholipid syndrome 9.9
42 pituitary adenoma 9.9
43 thrombophlebitis 9.9
44 mature teratoma 9.9
45 adenoma 9.9
46 meningitis 9.9
47 pulmonary embolism 9.9
48 pathologic nystagmus 9.9
49 tuberculous meningitis 9.9
50 aneurysm 9.9

Graphical network of the top 20 diseases related to Fourth Cranial Nerve Palsy:



Diseases related to Fourth Cranial Nerve Palsy

Symptoms & Phenotypes for Fourth Cranial Nerve Palsy

Drugs & Therapeutics for Fourth Cranial Nerve Palsy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355

Search NIH Clinical Center for Fourth Cranial Nerve Palsy

Genetic Tests for Fourth Cranial Nerve Palsy

Anatomical Context for Fourth Cranial Nerve Palsy

MalaCards organs/tissues related to Fourth Cranial Nerve Palsy:

41
Eye, Pituitary, Pineal

Publications for Fourth Cranial Nerve Palsy

Articles related to Fourth Cranial Nerve Palsy:

(show all 44)
# Title Authors PMID Year
1
A case of bilateral fourth nerve palsy associated with pseudotumor cerebri syndrome. 38
31038553 2019
2
Acquired onset of third, fourth, and sixth cranial nerve palsies in children and adolescents. 38
30760897 2019
3
Ocular Misalignment in Dizzy Patients-Something's A-Skew. 38
30883490 2019
4
Incidence and Etiology of Presumed Fourth Cranial Nerve Palsy: A Population-based Study. 38
29102606 2018
5
Pituitary Apoplexy Presenting as Ophthalmoplegia and Altered Level of Consciousness without Headache. 38
29854489 2018
6
Ocular Causes of Abnormal Head Position: Strabismus Clinic Data. 38
28845325 2017
7
Isolated fourth cranial nerve palsy due to pituitary macroadenoma. 38
28050074 2016
8
The Development of Hypertrophic Inferior Olivary Nucleus in Oculopalatal Tremor. 38
27928422 2016
9
Fourth cranial nerve palsy and bilateral acute retinal necrosis following human herpesvirus 6 infection of the central nervous system. 38
24328436 2014
10
Management of congenital fourth cranial nerve palsy. 38
24661367 2014
11
Cyclotropia to differentiate longstanding and acute fourth cranial nerve palsy. 38
25313119 2014
12
Persistent diplopia and superior oblique muscle dysfunction following dissection of the orbital periosteum in cranial base surgery. 38
23913249 2013
13
Fourth cranial nerve palsy and Brown syndrome: two interrelated congenital cranial dysinnervation disorders? 38
23636931 2013
14
Varicella zoster virus infection presenting as isolated diplopia: a case report. 38
23497310 2013
15
Radiation-induced ocular motor cranial nerve palsies in patients with pituitary tumor. 38
21857187 2011
16
Germinoma presenting as a fourth cranial nerve palsy in a patient with adenomatous polyposis coli (APC) gene mutation. 38
21315632 2011
17
Attention deficit hyperactivity disorder: diagnosis and treatment masking the ophthalmic clinical presentation of a pineal gland tumour in a teenager. 38
20225001 2010
18
Fourth cranial nerve palsy in a collegiate lacrosse player: a case report. 38
20617917 2010
19
Effect of ocular torsion on A and V patterns and apparent oblique muscle overaction. 38
20547948 2010
20
An unusual collision tumor comprising a prolactinoma and a plasmocytoma originating from the sellar region. 38
18846427 2010
21
CT demonstration of dorsal midbrain hemorrhage in traumatic fourth cranial nerve palsy. 38
20182210 2010
22
Stereotactic radiosurgery in two cases of presumed fourth cranial nerve schwannoma. 38
19458578 2009
23
Early propofol infusion syndrome following cerebral angiographic embolization for giant aneurysm repair. Case report. 38
17330542 2007
24
Incidence and types of childhood hypertropia: a population-based study. 38
16647125 2006
25
A case of PHACE syndrome. 38
16197426 2005
26
Bilateral fourth-nerve palsy occurring after shaking injury in infancy. 38
15226732 2004
27
[Strabismus surgery of the myopic patient under topical anaesthesia]. 38
14648370 2003
28
Quantitative changes in the field of binocular single vision following a fadenoperation to a vertical rectus muscle. 38
12381988 2002
29
Superior oblique palsy in a patient with a history of perineural spread from a periorbital squamous cell carcinoma. 38
11130747 2000
30
Painful fourth cranial nerve palsy caused by posteriorly-draining dural carotid-cavernous sinus fistula. 38
11000739 2000
31
Clinical diversity of hereditary Duane's retraction syndrome. 38
10711888 2000
32
Fourth cranial nerve palsy in pediatric patients with pseudotumor cerebri. 38
10030583 1999
33
Schwannoma in patients with isolated unilateral trochlear nerve palsy. 38
10030561 1999
34
Transitory fourth cranial nerve palsy due to foramen ovale electrode placement. 38
9309297 1997
35
Diplopia following head injury. 38
2276794 1990
36
Bilateral ophthalmoplegia during percutaneous transluminal coronary angioplasty. 38
2361198 1990
37
Left trochlear nerve palsy, unique symptom of an arachnoid cyst of the quadrigeminal plate. Case report. 38
2275426 1990
38
Congenital fourth nerve palsy and occult cranium bifidum. 38
3242538 1988
39
Fourth cranial nerve palsy following spinal anesthesia. A case report. 38
2952674 1987
40
Traumatic trochlear-nerve palsy due to haematoma. 38
3758505 1986
41
Primary-position hypotropia after anterior transposition of the inferior oblique. 38
3947298 1986
42
Familial congenital superior oblique palsy. 38
3951819 1986
43
Familial congenital fourth cranial nerve palsy. 38
3985833 1985
44
Ocular myasthenia presenting as superior oblique weakness. 38
6226695 1982

Variations for Fourth Cranial Nerve Palsy

Expression for Fourth Cranial Nerve Palsy

Search GEO for disease gene expression data for Fourth Cranial Nerve Palsy.

Pathways for Fourth Cranial Nerve Palsy

Pathways related to Fourth Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.19 PPBP PF4 HCK
2
Show member pathways
11.66 PPBP PF4
3 10.89 PRNP APC
4 10.65 PRL HCK
5 10.04 PRNP HCK

GO Terms for Fourth Cranial Nerve Palsy

Cellular components related to Fourth Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 platelet alpha granule lumen GO:0031093 8.62 PPBP PF4

Biological processes related to Fourth Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of angiogenesis GO:0016525 9.4 PRL PF4
2 neutrophil chemotaxis GO:0030593 9.37 PPBP PF4
3 inflammatory response GO:0006954 9.33 PPBP PF4 HCK
4 chemokine-mediated signaling pathway GO:0070098 9.32 PPBP PF4
5 antimicrobial humoral immune response mediated by antimicrobial peptide GO:0061844 9.26 PPBP PF4
6 positive regulation of cell death GO:0010942 8.96 PRNP APC
7 leukocyte chemotaxis GO:0030595 8.62 PPBP PF4

Molecular functions related to Fourth Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 8.62 PPBP PF4

Sources for Fourth Cranial Nerve Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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