MCID: FRT001
MIFTS: 28

Fourth Cranial Nerve Palsy

Categories: Eye diseases, Neuronal diseases, Rare diseases, Genetic diseases

Aliases & Classifications for Fourth Cranial Nerve Palsy

MalaCards integrated aliases for Fourth Cranial Nerve Palsy:

Name: Fourth Cranial Nerve Palsy 12 15
Fourth or Trochlear Nerve Palsy 12
Fourth Cranial Nerve Paresis 73
Fourth Nerve Palsy 12

Classifications:



External Ids:

Disease Ontology 12 DOID:10869
ICD10 33 H49.1

Summaries for Fourth Cranial Nerve Palsy

MalaCards based summary : Fourth Cranial Nerve Palsy, also known as fourth or trochlear nerve palsy, is related to cranial nerve palsy and fourth cranial nerve palsy, familial congenital. An important gene associated with Fourth Cranial Nerve Palsy is APC (APC, WNT Signaling Pathway Regulator), and among its related pathways/superpathways are G12-G13 in Cellular Signaling and Copper homeostasis. Affiliated tissues include eye and pituitary.

Wikipedia : 76 Fourth cranial nerve palsy also known as Trochlear nerve palsy, is a condition affecting Cranial Nerve 4... more...

Related Diseases for Fourth Cranial Nerve Palsy

Diseases in the Fourth Cranial Nerve Palsy family:

Fourth Cranial Nerve Palsy, Familial Congenital

Diseases related to Fourth Cranial Nerve Palsy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 cranial nerve palsy 30.6 APC CHN1
2 fourth cranial nerve palsy, familial congenital 12.6
3 congenital trochlear nerve palsy 11.7
4 intracranial hypertension, idiopathic 9.9
5 brown syndrome 9.9
6 retinitis 9.9
7 cyclotropia 9.9
8 mccune-albright syndrome 9.8 APC PRL
9 temporal arteritis 9.8
10 fibrous dysplasia 9.7 APC PRL
11 encephalopathy 9.1 PRNP RANBP2
12 paralytic squint 7.6 CHN1 HCK PRL PRNP RANBP2

Graphical network of the top 20 diseases related to Fourth Cranial Nerve Palsy:



Diseases related to Fourth Cranial Nerve Palsy

Symptoms & Phenotypes for Fourth Cranial Nerve Palsy

Drugs & Therapeutics for Fourth Cranial Nerve Palsy

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Teeth and Jaw Misalignment in Patients Suffering From Congenital Fourth Cranial Nerve Palsy Unknown status NCT02149355
2 Measuring Cyclotorsion on Scanning Laser Ophthalmoscopy (SLO)-Fundus Photographs Completed NCT02631369 Not Applicable
3 Effects of Ocular Electroacupuncture on Trochlear Nerve Palsy Recruiting NCT03099473 Not Applicable
4 Genetic Studies of Strabismus, Congenital Cranial Dysinnervation Disorders (CCDDs), and Their Associated Anomalies Recruiting NCT03059420
5 A Retrospective Study of the Effects of Ocular Acupuncture on Ocular Motor Nerve Palsy Not yet recruiting NCT03461809

Search NIH Clinical Center for Fourth Cranial Nerve Palsy

Genetic Tests for Fourth Cranial Nerve Palsy

Anatomical Context for Fourth Cranial Nerve Palsy

MalaCards organs/tissues related to Fourth Cranial Nerve Palsy:

41
Eye, Pituitary

Publications for Fourth Cranial Nerve Palsy

Articles related to Fourth Cranial Nerve Palsy:

(show all 14)
# Title Authors Year
1
Incidence and Etiology of Presumed Fourth Cranial Nerve Palsy: A Population-based Study. ( 29102606 )
2018
2
Isolated fourth cranial nerve palsy due to pituitary macroadenoma. ( 28050074 )
2016
3
Cyclotropia to differentiate longstanding and acute fourth cranial nerve palsy. ( 25313119 )
2014
4
Management of congenital fourth cranial nerve palsy. ( 24661367 )
2014
5
Fourth Cranial Nerve Palsy and Bilateral Acute Retinal Necrosis following Human Herpesvirus 6 Infection of the Central Nervous System. ( 24328436 )
2013
6
Fourth cranial nerve palsy and Brown syndrome: two interrelated congenital cranial dysinnervation disorders? ( 23636931 )
2013
7
Germinoma presenting as a fourth cranial nerve palsy in a patient with adenomatous polyposis coli (APC) gene mutation. ( 21315632 )
2011
8
CT demonstration of dorsal midbrain hemorrhage in traumatic fourth cranial nerve palsy. ( 20182210 )
2010
9
Fourth cranial nerve palsy in a collegiate lacrosse player: a case report. ( 20617917 )
2010
10
Painful fourth cranial nerve palsy caused by posteriorly-draining dural carotid-cavernous sinus fistula. ( 11000739 )
2000
11
Fourth cranial nerve palsy in pediatric patients with pseudotumor cerebri. ( 10030583 )
1999
12
Transitory fourth cranial nerve palsy due to foramen ovale electrode placement. ( 9309297 )
1997
13
Fourth cranial nerve palsy following spinal anesthesia. A case report. ( 2952674 )
1987
14
Familial congenital fourth cranial nerve palsy. ( 3985833 )
1985

Variations for Fourth Cranial Nerve Palsy

Expression for Fourth Cranial Nerve Palsy

Search GEO for disease gene expression data for Fourth Cranial Nerve Palsy.

Pathways for Fourth Cranial Nerve Palsy

Pathways related to Fourth Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.35 APC CHN1
2 10.89 APC PRNP
3 10.65 HCK PRL
4 10.04 HCK PRNP

GO Terms for Fourth Cranial Nerve Palsy

Biological processes related to Fourth Cranial Nerve Palsy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle arrest GO:0007050 8.96 APC PRNP
2 positive regulation of cell death GO:0010942 8.62 APC PRNP

Sources for Fourth Cranial Nerve Palsy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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