MCID: FXF002
MIFTS: 27

Fox-Fordyce Disease

Categories: Endocrine diseases, Rare diseases, Skin diseases

Aliases & Classifications for Fox-Fordyce Disease

MalaCards integrated aliases for Fox-Fordyce Disease:

Name: Fox-Fordyce Disease 12 74 52 43 15
Fox Fordyce Disease 12 17 71
Apocrine Miliaria 52 32
Fox-Fordyce Syndrome 52
Miliaria, Apocrine 52

Classifications:



External Ids:

Disease Ontology 12 DOID:1381
ICD9CM 34 705.82
MeSH 43 D005588
NCIt 49 C84716
SNOMED-CT 67 65038009
ICD10 32 L75.2
UMLS 71 C0016632

Summaries for Fox-Fordyce Disease

NIH Rare Diseases : 52 Fox-Fordyce disease is a chronic skin disease most common in women aged 13-35 years. It is characterized by the development of intense itching in the underarm area, the pubic area, and around the nipple of the breast as a result of perspiration which becomes trapped in the sweat gland and surrounding areas. The cause is unknown, but heat, humidity, and stress may play a role. Treatment may include the use of retinoids , antibiotics , and immunosuppressants.

MalaCards based summary : Fox-Fordyce Disease, also known as fox fordyce disease, is related to sweat gland disease and neurodermatitis, and has symptoms including flesh colored papules An important gene associated with Fox-Fordyce Disease is TPRA1 (Transmembrane Protein Adipocyte Associated 1), and among its related pathways/superpathways is Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include skin, breast and liver.

Disease Ontology : 12 A sweat gland disease that is characterized by dilatation of the follicular infundibulum with hyperkeratosis, acanthosis, and spongiosis with perifollicular inflammation leading to hair loss and has symptom flesh colored papules with hair loss and pruritis, especially of the axilla.

Wikipedia : 74 Fox-Fordyce disease is a chronic blockage of the sweat gland ducts with a secondary, non-bacterial... more...

Related Diseases for Fox-Fordyce Disease

Diseases related to Fox-Fordyce Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 62)
# Related Disease Score Top Affiliating Genes
1 sweat gland disease 30.2 PIP CEACAM5
2 neurodermatitis 30.1 TPRA1 MRGPRD
3 xanthomatosis 10.6
4 keratosis 10.6
5 miliaria rubra 10.6
6 miliaria 10.6
7 skin disease 10.5
8 hidradenitis 10.5
9 pityriasis rubra pilaris 10.4
10 mitral valve stenosis 10.4
11 syringoma 10.4
12 hidradenitis suppurativa 10.4
13 granulosis rubra nasi 10.2
14 lipomatosis, multiple 10.2
15 pleomorphic lipoma 10.2
16 axillary lipoma 10.2
17 gonadal dysgenesis 10.2
18 turner syndrome 10.2
19 spongiotic dermatitis 10.2
20 amyloidosis 10.2
21 posttransplant acute limbic encephalitis 10.2
22 lichen amyloidosis 10.2
23 dermatitis 10.2
24 contact dermatitis 10.2
25 vulvar syringoma 10.2 PIP CEACAM5
26 vulvar eccrine porocarcinoma 10.2 PIP CEACAM5
27 apocrine adenoma 10.2 PIP CEACAM5
28 vulval paget's disease 10.2 PIP CEACAM5
29 nodular hidradenoma 10.1 PIP CEACAM5
30 hidradenoma 10.1 PIP CEACAM5
31 eccrine adenocarcinoma 10.1 PIP CEACAM5
32 anal paget's disease 10.1 PIP CEACAM5
33 vulva adenocarcinoma 10.1 PIP CEACAM5
34 vulvar apocrine adenocarcinoma 10.1 PIP CEACAM5
35 eccrine papillary adenocarcinoma 10.1 PIP CEACAM5
36 papillary adenocarcinoma 10.1 PIP CEACAM5
37 malignant syringoma 10.1 PIP CEACAM5
38 eccrine papillary adenoma 10.1 PIP CEACAM5
39 clear cell hidradenoma 10.1 PIP CEACAM5
40 eccrine sweat gland cancer 10.1 PIP CEACAM5
41 sweat gland cancer 10.1 PIP CEACAM5
42 hidrocystoma 10.1 PIP CEACAM5
43 submandibular gland cancer 10.1 PIP CABIN1
44 eccrine acrospiroma 10.1 PIP CEACAM5
45 linitis plastica 10.1 PIP CEACAM5
46 eccrine sweat gland neoplasm 10.1 PIP CEACAM5
47 sweat gland neoplasm 10.0 PIP CEACAM5
48 cutaneous adenocystic carcinoma 10.0 PIP CEACAM5
49 apocrine sweat gland neoplasm 10.0 PIP CEACAM5
50 gastric diffuse adenocarcinoma 10.0 PIP CEACAM5

Graphical network of the top 20 diseases related to Fox-Fordyce Disease:



Diseases related to Fox-Fordyce Disease

Symptoms & Phenotypes for Fox-Fordyce Disease

Symptoms:

12
  • flesh colored papules

Drugs & Therapeutics for Fox-Fordyce Disease

Search Clinical Trials , NIH Clinical Center for Fox-Fordyce Disease

Cochrane evidence based reviews: fox-fordyce disease

Genetic Tests for Fox-Fordyce Disease

Anatomical Context for Fox-Fordyce Disease

MalaCards organs/tissues related to Fox-Fordyce Disease:

40
Skin, Breast, Liver

Publications for Fox-Fordyce Disease

Articles related to Fox-Fordyce Disease:

(show top 50) (show all 132)
# Title Authors PMID Year
1
Rapid remission with calcipotriol betamethasone in refractory Fox-Fordyce disease. 61
31917488 2020
2
Fox-Fordyce disease: Insights from cases induced by laser hair removal. 61
31734939 2019
3
[Fox-Fordyce disease on the peristernal region: a rare and atypical case]. 61
31303946 2019
4
Fox-Fordyce disease: report of two cases with perifollicular xanthomatosis on histological image. 61
30066765 2018
5
[Axillary and perimamillary Fox-Fordyce disease (apocrine miliaria) in a 19-year-old woman]. 61
29110043 2018
6
Fox-Fordyce disease. 61
29641729 2018
7
Can Fractionated Microneedle Radiofrequency be an Effective Procedure for Treatment of Fox-Fordyce Disease? A Medical Hypothesis. 61
29862220 2018
8
Professional interest in dermatopathology of Stanisław Ostrowski - the only one State Polish President among physicians. 61
29517196 2017
9
Successful treatment of areolar Fox-Fordyce disease with surgical excision and 1550-nm fractionated erbium glass laser. 61
27072751 2016
10
Fox-Fordyce Disease: An under-diagnosed adverse event of laser hair removal? 61
27135989 2016
11
Effective treatment of Fox-Fordyce disease with pulsed dye laser. 61
27623097 2016
12
Inflammatory and glandular skin disease in pregnancy. 61
27265071 2016
13
A female case of Fox-Fordyce disease. 61
27226051 2016
14
In vivo features of Fox-Fordyce disease in high-definition optical coherence tomography. 61
26972218 2016
15
Successful treatment of refractory pruritic Fox-Fordyce disease with botulinum toxin type A. 61
26385128 2016
16
Fox-Fordyce Disease. 61
26909204 2016
17
Fox-Fordyce disease of the vulva. 61
27190415 2016
18
In vivo features of Fox-Fordyce disease in high-definition optical coherence tomography. 61
26713641 2016
19
A novel modality using microwave technology for the treatment of Fox-Fordyce disease (FFD). 61
27051811 2016
20
Axillary syringomas mimicking Fox-Fordyce disease. 61
26500884 2015
21
[UROLOGICAL ASPECTS OF THE FOX - FORDYCE DISEASE]. 61
26094399 2015
22
Fox-Fordyce disease: a report of 2 cases responding to topical clindamycin. 61
25566917 2015
23
Lesions in the axilla after hair removal using intense pulsed light. Fox-Fordyce disease. 61
24838226 2015
24
Clinical Effects of Topical Tacrolimus on Fox-Fordyce Disease. 61
26171257 2015
25
Deciphering the functions of the hair follicle infundibulum in skin physiology and disease. 61
25248789 2014
26
Fox Fordyce disease as a secondary effect of laser hair removal. 61
24131099 2014
27
Fox-Fordyce disease treatment with fractional CO2 laser. 61
24261728 2013
28
Fox-Fordyce disease with an atypical clinical presentation. 61
23260875 2013
29
Fox-Fordyce-like disease following laser hair removal appearing on all treated areas. 61
23318918 2013
30
Diseases associated with hidranitis suppurativa: part 2 of a series on hidradenitis. 61
24011308 2013
31
Anti-human milk fat globulin staining of perifollicular xanthomatosis in Fox-Fordyce disease. 61
23181442 2012
32
Fox-Fordyce disease. 61
23286818 2012
33
Histopathology attributes of Fox-Fordyce disease. 61
23067079 2012
34
Rare sweat gland tumors of vulva: Report of two cases. 61
23188940 2012
35
Clinical effects of topical pimecrolimus in a patient with Fox-Fordyce disease. 61
22571582 2012
36
Fox-Fordyce disease: response to adapalene 0.1%. 61
22570049 2012
37
Fox-Fordyce disease in monozygotic female twins. 61
21679831 2011
38
Fox-Fordyce Disease (Apocrine Miliaria). 61
21751451 2011
39
Fox-Fordyce disease following axillary laser hair removal. 61
21576577 2011
40
Fox-Fordyce disease exacerbated by hyperhidrosis. 61
20537067 2010
41
Clinicopathological study of Fox-Fordyce disease. 61
19712275 2009
42
Dilation of apocrine glands. A forgotten but helpful histopathological clue to the diagnosis of axillary Fox-Fordyce disease. 61
19461248 2009
43
Fox-Fordyce disease in daughter and father. 61
19060475 2009
44
Perifollicular xanthomatosis as the hallmark of axillary Fox-Fordyce disease: an evaluation of histopathologic features of 7 cases. 61
18711075 2008
45
Pruritic axillary papules. Fox-Fordyce disease. 61
18619083 2008
46
[Perifollicular xanthomatosis as a key histological finding in Fox-Fordyce disease]. 61
18346437 2008
47
[Fox-Fordyce disease]. 61
17384561 2007
48
Pimecrolimus is effective in Fox-Fordyce disease. 61
16961542 2006
49
Fox fordyce disease in a prepubertal girl. 61
15660912 2005
50
Patterns histopathologic of Fox-Fordyce disease. 61
15618931 2004

Variations for Fox-Fordyce Disease

Expression for Fox-Fordyce Disease

Search GEO for disease gene expression data for Fox-Fordyce Disease.

Pathways for Fox-Fordyce Disease

Pathways related to Fox-Fordyce Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.69 CEACAM5 CD68

GO Terms for Fox-Fordyce Disease

Sources for Fox-Fordyce Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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