MCID: FRL002
MIFTS: 20

Froelich Syndrome

Categories: Neuronal diseases

Aliases & Classifications for Froelich Syndrome

MalaCards integrated aliases for Froelich Syndrome:

Name: Froelich Syndrome 12 15
Froehlich's Syndrome 12 71
Froelich's Syndrome 12 74
Babinski-Froelich Syndrome 12
Adiposogenital Syndrome 12
Froehlich Syndrome 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6676
MeSH 44 D007027
NCIt 50 C34625
SNOMED-CT 67 62999006
ICD10 32 E23.6
UMLS 71 C0016724

Summaries for Froelich Syndrome

Disease Ontology : 12 A hypothalamic disease that is characterized by endocrine dysfunction of the hypothalamic gland resulting in delayed puberty, small testes, and obesity.

MalaCards based summary : Froelich Syndrome, also known as froehlich's syndrome, is related to acromegaly and hypothalamic obesity. An important gene associated with Froelich Syndrome is MS4A6E (Membrane Spanning 4-Domains A6E). Affiliated tissues include pituitary, testes and hypothalamus.

Wikipedia : 74 Adiposogenital dystrophy is a condition that may be caused by tertiary hypogonadism originating from... more...

Related Diseases for Froelich Syndrome

Diseases related to Froelich Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 15)
# Related Disease Score Top Affiliating Genes
1 acromegaly 29.5 TRH GHSR
2 hypothalamic obesity 11.1
3 myotonic dystrophy 10.2
4 diabetes insipidus 10.1
5 craniopharyngioma 10.0
6 basophil adenoma 10.0 MS4A6E MS4A4A
7 alzheimer disease 4 10.0 MS4A6E MS4A4A
8 dysostosis 9.9
9 bardet-biedl syndrome 9.9
10 retinal degeneration 9.9
11 meningitis 9.9
12 pituitary adenoma, prolactin-secreting 9.8 TRH GHSR
13 pituitary adenoma 9.8 TRH GHSR
14 leptin deficiency or dysfunction 9.4 TRH SH2B1 GHSR
15 body mass index quantitative trait locus 11 9.2 TRH SH2B1 GHSR

Graphical network of the top 20 diseases related to Froelich Syndrome:



Diseases related to Froelich Syndrome

Symptoms & Phenotypes for Froelich Syndrome

Drugs & Therapeutics for Froelich Syndrome

Search Clinical Trials , NIH Clinical Center for Froelich Syndrome

Genetic Tests for Froelich Syndrome

Anatomical Context for Froelich Syndrome

MalaCards organs/tissues related to Froelich Syndrome:

40
Pituitary, Testes, Hypothalamus

Publications for Froelich Syndrome

Articles related to Froelich Syndrome:

# Title Authors PMID Year
1
[Babinski-Froelich syndrome with grave anemia; from gynoid to android obesity]. 61
13008152 1952
2
[Froelich syndrome (craniopharyngioma); report of a case]. 61
14892342 1951
3
On a case of adiposogenital Froelich syndrome secondary to sphenoid perisinusitis treated with multiple hypofisart grafts. 61
18144117 1949
4
THE ADULT EQUIVALENT OF THE FROELICH SYNDROME. 61
18739184 1924

Variations for Froelich Syndrome

Expression for Froelich Syndrome

Search GEO for disease gene expression data for Froelich Syndrome.

Pathways for Froelich Syndrome

GO Terms for Froelich Syndrome

Biological processes related to Froelich Syndrome according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.26 TRH SH2B1 GHSR CCL28
2 hormone-mediated signaling pathway GO:0009755 8.62 TRH GHSR

Sources for Froelich Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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