Froelich Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Froelich Syndrome

MalaCards integrated aliases for Froelich Syndrome:

Name: Froelich Syndrome ¹² ¹⁵

Froehlich's Syndrome ¹² ⁷¹

Froelich's Syndrome ¹² ⁷⁴

Babinski-Froelich Syndrome ¹²

Adiposogenital Syndrome ¹²

Froehlich Syndrome ¹²

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Endocrine, nutritional and metabolic diseases

Disorders of other endocrine glands

Hypofunction and other disorders of pituitary gland

Other disorders of pituitary gland

External Ids:

Disease Ontology ¹² DOID:6676

MeSH ⁴³ D007027

NCIt ⁴⁹ C34625

SNOMED-CT ⁶⁷ 62999006

ICD10 ³² E23.6

UMLS ⁷¹ C0016724

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Summaries for Froelich Syndrome

Disease Ontology : ¹² A hypothalamic disease that is characterized by endocrine dysfunction of the hypothalamic gland resulting in delayed puberty, small testes, and obesity.

MalaCards based summary : Froelich Syndrome, also known as froehlich's syndrome, is related to hypothalamic obesity and diabetes insipidus. An important gene associated with Froelich Syndrome is MS4A6E (Membrane Spanning 4-Domains A6E). Affiliated tissues include testes, hypothalamus and pituitary.

Wikipedia : ⁷⁴ Adiposogenital dystrophy is a condition which may be caused by tertiary hypogonadism originating from... more...

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Related Diseases for Froelich Syndrome

Diseases related to Froelich Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 24)

#	Related Disease	Score	Top Affiliating Genes
1	hypothalamic obesity	11.3
2	diabetes insipidus	10.2
3	anemia, x-linked, with or without neutropenia and/or platelet abnormalities	10.2
4	deficiency anemia	10.2
5	craniopharyngioma	10.2
6	body mass index quantitative trait locus 11	10.0
7	body mass index quantitative trait locus 9	10.0
8	body mass index quantitative trait locus 8	10.0
9	body mass index quantitative trait locus 4	10.0
10	body mass index quantitative trait locus 10	10.0
11	body mass index quantitative trait locus 7	10.0
12	body mass index quantitative trait locus 12	10.0
13	body mass index quantitative trait locus 14	10.0
14	body mass index quantitative trait locus 18	10.0
15	body mass index quantitative trait locus 19	10.0
16	body mass index quantitative trait locus 20	10.0
17	dysostosis	10.0
18	bardet-biedl syndrome	10.0
19	acromegaly	10.0
20	retinal degeneration	10.0
21	meningitis	10.0
22	basophil adenoma	9.9	MS4A6E MS4A4A
23	alzheimer disease 4	9.8	MS4A6E MS4A4A
24	leptin deficiency or dysfunction	9.5	SH2B1 GHSR

Graphical network of the top 20 diseases related to Froelich Syndrome:

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Symptoms & Phenotypes for Froelich Syndrome

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Drugs & Therapeutics for Froelich Syndrome

Search Clinical Trials , NIH Clinical Center for Froelich Syndrome

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Genetic Tests for Froelich Syndrome

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Anatomical Context for Froelich Syndrome

MalaCards organs/tissues related to Froelich Syndrome:

⁴⁰

Testes, Hypothalamus, Pituitary

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Publications for Froelich Syndrome

Articles related to Froelich Syndrome:

#	Title	Authors	PMID	Year
1	[Babinski-Froelich syndrome with grave anemia; from gynoid to android obesity]. ⁶¹	LANGERON L	13008152	1952
2	[Froelich syndrome (craniopharyngioma); report of a case]. ⁶¹	CORREA BORQUEZ O	14892342	1951
3	THE ADULT EQUIVALENT OF THE FROELICH SYNDROME. ⁶¹	Abbott GK	18739184	1924

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Genes for Froelich Syndrome

Genes related to Froelich Syndrome (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	MS4A6E	Membrane Spanning 4-Domains A6E	Protein Coding	5.28	DISEASES inferred ¹⁵
2	MS4A4A	Membrane Spanning 4-Domains A4A	Protein Coding	5.04	DISEASES inferred ¹⁵
3	MAN2C1	Mannosidase Alpha Class 2C Member 1	Protein Coding	4.94	DISEASES inferred ¹⁵
4	GHSR	Growth Hormone Secretagogue Receptor	Protein Coding	4.82	DISEASES inferred ¹⁵
5	FMO3	Flavin Containing Dimethylaniline Monoxygenase 3	Protein Coding	4.58	DISEASES inferred ¹⁵
6	CCL28	C-C Motif Chemokine Ligand 28	Protein Coding	4.54	DISEASES inferred ¹⁵
7	SH2B1	SH2B Adaptor Protein 1	Protein Coding	4.49	DISEASES inferred ¹⁵

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Variations for Froelich Syndrome

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Expression for Froelich Syndrome

Search GEO for disease gene expression data for Froelich Syndrome.

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Pathways for Froelich Syndrome

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GO Terms for Froelich Syndrome

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Sources for Froelich Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

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⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

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¹⁶ DrugBank

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¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

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⁴⁰ MalaCards

⁴¹ MedGen

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⁴³ MeSH

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⁴⁷ NCBI Bookshelf

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⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

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⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia