Froelich Syndrome disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Froelich Syndrome

MalaCards integrated aliases for Froelich Syndrome:

Name: Froelich Syndrome ¹² ¹⁵

Froehlich's Syndrome ¹² ⁷¹

Froelich's Syndrome ¹² ⁷⁴

Babinski-Froelich Syndrome ¹²

Adiposogenital Syndrome ¹²

Froehlich Syndrome ¹²

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³²

Endocrine, nutritional and metabolic diseases

Disorders of other endocrine glands

Hypofunction and other disorders of pituitary gland

Other disorders of pituitary gland

External Ids:

Disease Ontology ¹² DOID:6676

MeSH ⁴³ D007027

NCIt ⁴⁹ C34625

SNOMED-CT ⁶⁷ 62999006

ICD10 ³² E23.6

UMLS ⁷¹ C0016724

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Summaries for Froelich Syndrome

Disease Ontology : ¹² A hypothalamic disease that is characterized by endocrine dysfunction of the hypothalamic gland resulting in delayed puberty, small testes, and obesity.

MalaCards based summary : Froelich Syndrome, also known as froehlich's syndrome, is related to body mass index quantitative trait locus 11 and hypothalamic obesity. An important gene associated with Froelich Syndrome is CCL28 (C-C Motif Chemokine Ligand 28), and among its related pathways/superpathways are Longevity regulating pathway and Adipocytokine signaling pathway. Affiliated tissues include testes, hypothalamus and pituitary.

Wikipedia : ⁷⁴ Adiposogenital dystrophy is a condition which may be caused by tertiary hypogonadism originating from... more...

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Related Diseases for Froelich Syndrome

Diseases related to Froelich Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 22)

#	Related Disease	Score	Top Affiliating Genes
1	body mass index quantitative trait locus 11	28.0	GHSR CNR2 ADIPOR2 ADIPOR1
2	hypothalamic obesity	11.3
3	diabetes insipidus	10.2
4	deficiency anemia	10.2
5	craniopharyngioma	10.2
6	body mass index quantitative trait locus 9	10.0
7	body mass index quantitative trait locus 8	10.0
8	body mass index quantitative trait locus 4	10.0
9	body mass index quantitative trait locus 10	10.0
10	body mass index quantitative trait locus 7	10.0
11	body mass index quantitative trait locus 12	10.0
12	body mass index quantitative trait locus 14	10.0
13	body mass index quantitative trait locus 18	10.0
14	body mass index quantitative trait locus 19	10.0
15	body mass index quantitative trait locus 20	10.0
16	dysostosis	10.0
17	bardet-biedl syndrome	10.0
18	acromegaly	10.0
19	meningitis	10.0
20	anorexia nervosa	9.7	GHSR ADIPOR1
21	overnutrition	9.4	ADIPOR2 ADIPOR1
22	fatty liver disease	9.2	ADIPOR2 ADIPOR1

Graphical network of the top 20 diseases related to Froelich Syndrome:

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Symptoms & Phenotypes for Froelich Syndrome

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Drugs & Therapeutics for Froelich Syndrome

Search Clinical Trials , NIH Clinical Center for Froelich Syndrome

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Genetic Tests for Froelich Syndrome

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Anatomical Context for Froelich Syndrome

MalaCards organs/tissues related to Froelich Syndrome:

⁴⁰

Testes, Hypothalamus, Pituitary

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Publications for Froelich Syndrome

Articles related to Froelich Syndrome:

#	Title	Authors	PMID	Year
1	[Babinski-Froelich syndrome with grave anemia; from gynoid to android obesity]. ⁶¹	LANGERON L	13008152	1952
2	[Froelich syndrome (craniopharyngioma); report of a case]. ⁶¹	CORREA BORQUEZ O	14892342	1951
3	THE ADULT EQUIVALENT OF THE FROELICH SYNDROME. ⁶¹	Abbott GK	18739184	1924

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Genes for Froelich Syndrome

Genes related to Froelich Syndrome (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CCL28	C-C Motif Chemokine Ligand 28	Protein Coding	4.89	DISEASES inferred ¹⁵
2	FAP	Fibroblast Activation Protein Alpha	Protein Coding	4.46	DISEASES inferred ¹⁵
3	GHSR	Growth Hormone Secretagogue Receptor	Protein Coding	4.36	DISEASES inferred ¹⁵
4	CNR2	Cannabinoid Receptor 2	Protein Coding	4.14	DISEASES inferred ¹⁵
5	ADIPOR2	Adiponectin Receptor 2	Protein Coding	4.1	DISEASES inferred ¹⁵
6	ADIPOR1	Adiponectin Receptor 1	Protein Coding	4.02	DISEASES inferred ¹⁵

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Variations for Froelich Syndrome

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Expression for Froelich Syndrome

Search GEO for disease gene expression data for Froelich Syndrome.

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Pathways for Froelich Syndrome

Pathways related to Froelich Syndrome according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Longevity regulating pathway ³⁶ Show member pathways Longevity regulating pathway - multiple species ³⁶	11.13	ADIPOR2 ADIPOR1
2	Adipocytokine signaling pathway ³⁶	10.46	ADIPOR2 ADIPOR1

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GO Terms for Froelich Syndrome

Cellular components related to Froelich Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	intrinsic component of plasma membrane	GO:0031226	8.62	ADIPOR2 ADIPOR1

Biological processes related to Froelich Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of inflammatory response	GO:0050728	9.48	GHSR CNR2
2	negative regulation of cell growth	GO:0030308	9.46	ADIPOR2 ADIPOR1
3	glucose homeostasis	GO:0042593	9.43	ADIPOR2 ADIPOR1
4	positive regulation of cold-induced thermogenesis	GO:0120162	9.4	ADIPOR2 ADIPOR1
5	female pregnancy	GO:0007565	9.37	GHSR ADIPOR2
6	response to nutrient	GO:0007584	9.32	CCL28 ADIPOR2
7	fatty acid oxidation	GO:0019395	9.26	ADIPOR2 ADIPOR1
8	regulation of fatty acid biosynthetic process	GO:0042304	9.16	ADIPOR2 ADIPOR1
9	adiponectin-activated signaling pathway	GO:0033211	8.96	ADIPOR2 ADIPOR1
10	hormone-mediated signaling pathway	GO:0009755	8.8	GHSR ADIPOR2 ADIPOR1

Molecular functions related to Froelich Syndrome according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	adiponectin binding	GO:0055100	8.96	ADIPOR2 ADIPOR1
2	adipokinetic hormone receptor activity	GO:0097003	8.62	ADIPOR2 ADIPOR1

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Sources for Froelich Syndrome

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia