FFA
MCID: FRN020
MIFTS: 42

Frontal Fibrosing Alopecia (FFA)

Categories: Eye diseases, Oral diseases, Rare diseases, Skin diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Frontal Fibrosing Alopecia

MalaCards integrated aliases for Frontal Fibrosing Alopecia:

Name: Frontal Fibrosing Alopecia 19 19 58 16 75
Lichen Planopilaris 19 58 53 5 16 31
Lichen Planus Follicularis 19 58 75 71 33
Follicular Lichen Planus 19 58 33
Lichen Follicularis 19 58
Ffa 19 58
Lpp 19 58
Postmenopausal Frontal Fibrosing Alopecia 71
Lichen Planopilaris Classic Type 19
Kossard Disease 19

Characteristics:


Age Of Onset:

Frontal Fibrosing Alopecia: Adult 58
Lichen Planopilaris: Adult 58

Classifications:

Orphanet: 58  
Rare skin diseases


External Ids:

ICD10 31 L66.1
MESH via Orphanet 44 C535892
ICD10 via Orphanet 32 L66.1
UMLS via Orphanet 72 C0023645 C1274700
ICD11 33 1963050127
UMLS 71 C0023645 C1274700

Summaries for Frontal Fibrosing Alopecia

GARD: 19 Frontal fibrosing alopecia (FFA) is a form of lichen planopilaris that is characterized primarily by slowly progressive hair loss (alopecia) and scarring on the scalp near the forehead. In some cases, the eyebrows, eye lashes and/or other parts of the body may be involved, as well. Although it has been suggested that FFA may be due to hormonal changes or an autoimmune response, the exact cause of this condition is not yet known.

MalaCards based summary: Frontal Fibrosing Alopecia, also known as lichen planopilaris, is related to alopecia and rare lichen planus. An important gene associated with Frontal Fibrosing Alopecia is PPARG (Peroxisome Proliferator Activated Receptor Gamma). The drugs Apremilast and Lidocaine have been mentioned in the context of this disorder. Affiliated tissues include skin, eye and myeloid, and related phenotypes are hyperkeratosis and alopecia

Orphanet 58 Frontal fibrosing alopecia: Frontal fibrosing alopecia (FFA) is a rare variant of lichen planopilaris (see this term) characterized by symmetrical, progressive, band-like anterior hair loss of the scalp.

Lichen planopilaris: A rare cutaneous variant of lichen planus which affects hair follicles. It may occur on its own or in association with more common forms of lichen planus, usually classical type and/or oral lichen planus.

Wikipedia 75 Frontal fibrosing alopecia: Frontal fibrosing alopecia is the frontotemporal hairline recession and eyebrow loss in postmenopausal... more...

Lichen planus follicularis: Lichen planus (LP) is a chronic inflammatory and immune-mediated disease that affects the skin, nails,... more...

Related Diseases for Frontal Fibrosing Alopecia

Diseases related to Frontal Fibrosing Alopecia via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 295)
# Related Disease Score Top Affiliating Genes
1 alopecia 11.4
2 rare lichen planus 11.3
3 lipomatosis, multiple 11.2
4 periodontitis, aggressive, 1 11.1
5 tetralogy of fallot 11.1
6 esophageal atresia 11.1
7 pneumonic plague 10.9
8 prostate carcinoma in situ 10.9
9 acute monoblastic leukemia 10.9
10 primary central nervous system lymphoma 10.9
11 lichen planus 10.9
12 schizophrenia 10.9
13 vacterl association, x-linked, with or without hydrocephalus 10.9
14 leukemia, acute myeloid 10.9
15 short-rib thoracic dysplasia 10 with or without polydactyly 10.9
16 retinitis pigmentosa 71 10.9
17 soft tissue chondroma 10.9
18 infiltrating lipoma 10.9
19 septic arthritis 10.9
20 alopecia areata 10.8
21 lichen planus pigmentosus 10.7
22 alopecia, androgenetic, 1 10.7
23 androgenic alopecia 10.7
24 hypothyroidism 10.6
25 vitiligo-associated multiple autoimmune disease susceptibility 6 10.6
26 vitiligo-associated multiple autoimmune disease susceptibility 1 10.6
27 lupus erythematosus 10.6
28 systemic lupus erythematosus 10.5
29 rosacea 10.5
30 type 2 diabetes mellitus 10.5
31 autoimmune disease 10.5
32 cutaneous lupus erythematosus 10.4
33 fanconi anemia, complementation group e 10.4
34 dilution, pigmentary 10.4
35 lichen sclerosus et atrophicus 10.4
36 contact dermatitis 10.4
37 graham-little-piccardi-lassueur syndrome 10.4
38 oral lichen planus 10.4
39 discoid lupus erythematosus 10.4
40 skin disease 10.4
41 sjogren syndrome 10.3
42 keratosis 10.3
43 folliculitis 10.3
44 hashimoto thyroiditis 10.2
45 thyroiditis 10.2
46 dermatitis herpetiformis 10.2
47 hypertriglyceridemia 1 10.2
48 hair whorl 10.2
49 psoriasis 7 10.2
50 telogen effluvium 10.2

Graphical network of the top 20 diseases related to Frontal Fibrosing Alopecia:



Diseases related to Frontal Fibrosing Alopecia

Symptoms & Phenotypes for Frontal Fibrosing Alopecia

Human phenotypes related to Frontal Fibrosing Alopecia:

58 30 (show all 15)
# Description HPO Frequency Orphanet Frequency HPO Source Accession
1 hyperkeratosis 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0000962
2 alopecia 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0001596
3 papule 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0200034
4 lichenification 58 30 Hallmark (90%) Very frequent (99-80%)
HP:0100725
5 abnormal fingernail morphology 58 30 Frequent (33%) Frequent (79-30%)
HP:0001231
6 skin ulcer 58 30 Frequent (33%) Frequent (79-30%)
HP:0200042
7 pruritus 58 30 Frequent (33%) Frequent (79-30%)
HP:0000989
8 dermal atrophy 58 30 Frequent (33%) Frequent (79-30%)
HP:0004334
9 hepatitis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0012115
10 hypopigmented skin patches 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001053
11 pterygium 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001059
12 abnormal blistering of the skin 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0008066
13 neoplasm of the oral cavity 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0100649
14 abnormal intestine morphology 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0002242
15 onycholysis 58 30 Occasional (7.5%) Occasional (29-5%)
HP:0001806

Drugs & Therapeutics for Frontal Fibrosing Alopecia

Drugs for Frontal Fibrosing Alopecia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apremilast Approved, Investigational Phase 4 608141-41-9 10151715 11561674
2
Lidocaine Approved, Vet_approved Phase 4 137-58-6 3676
3 Analgesics Phase 4
4 Antirheumatic Agents Phase 4
5 Phosphodiesterase Inhibitors Phase 4
6 Phosphodiesterase 4 Inhibitors Phase 4
7 Anti-Inflammatory Agents, Non-Steroidal Phase 4
8 Analgesics, Non-Narcotic Phase 4
9 Anti-Inflammatory Agents Phase 4
10 Anti-Arrhythmia Agents Phase 4
11 Sodium Channel Blockers Phase 4
12 Anesthetics, Local Phase 4
13 Anesthetics Phase 4
14 Diuretics, Potassium Sparing Phase 4
15
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
16
Ethanol Approved Phase 2 64-17-5 702
17
Naltrexone Approved, Investigational, Vet_approved Phase 2 16590-41-3 5360515
18 Alkylating Agents Phase 2
19 Antineoplastic Agents, Alkylating Phase 2
20 Narcotic Antagonists Phase 2
21 Narcotics Phase 2
22 Immunologic Factors Phase 2
23 Immunoglobulins Phase 2
24 Antibodies, Monoclonal Phase 2
25 Antibodies Phase 2
26
Triamcinolone Approved, Vet_approved 124-94-7 31307
27
Gabapentin Approved, Investigational Early Phase 1 60142-96-3 3446
28
Ixekizumab Approved, Investigational Early Phase 1 1143503-69-8
29
Triamcinolone hexacetonide
30
Triamcinolone diacetate
31
Triamcinolone Acetonide 6436
32 Neurotransmitter Agents Early Phase 1
33 Anti-Anxiety Agents Early Phase 1
34 Excitatory Amino Acid Antagonists Early Phase 1
35 Psychotropic Drugs Early Phase 1
36 Anticonvulsants Early Phase 1
37 Pharmaceutical Solutions Early Phase 1
38 Dermatologic Agents Early Phase 1

Interventional clinical trials:

(show all 13)
# Name Status NCT ID Phase Drugs
1 Open Label Trial Evaluating the Efficacy of Apremilast for the Treatment of Frontal Fibrosing Alopecia Unknown status NCT03422640 Phase 4 Apremilast
2 The Use of Local Anesthetic in Intralesional Corticosteroid Injections; A Randomized, Double Blind Controlled Trial Completed NCT03630198 Phase 4 Corticosteroid with lidocaine;Corticosteroid with normal saline
3 Valchlor in the Treatment of Lichen Planopilaris: A Single Arm, Open- Label, Exploratory Study Completed NCT03417141 Phase 2 Mechlorethamine 0.016% Top Gel
4 Oral Low-Dose Naltrexone in the Treatment of Lichen Planopilaris and Frontal Fibrosing Alopecia; an Uncontrolled Open-label Prospective Study Completed NCT04409041 Phase 2 Low-Dose Naltrexone
5 A Proof of Concept Study to Evaluate the Efficacy, Safety and Tolerability of Secukinumab 300 mg Over 32 Weeks in Adult Patients With Biopsy-proven Forms of Lichen Planus Not Adequately Controlled With Topical Therapies - PRELUDE Completed NCT04300296 Phase 2 Cutaneous lichen planus secukinumab 300 mg Q4W;Cutaneous lichen planus placebo;Mucosal lichen planus placebo;Lichen planopilaris placebo;Mucosal lichen planus secukinumab 300 mg Q4W;Lichen planopilaris secukinumab 300 mg Q4W
6 A Phase 2a, Randomized, Double-Blind, Vehicle-Controlled, Single Site, Exploratory Trial to Assess the Effect of Delgocitinib Cream 20 mg/g on the Molecular Signature, Safety, and Efficacy in Adults With Frontal Fibrosing Alopecia Recruiting NCT05332366 Phase 2 Delgocitinib cream;Delgocitinib cream vehicle
7 Prospective Double-blind, Placebo Controlled Study to Assess the Efficacy of Intralesional Corticoid on the Treatment of Frontal Fibrosing Alopecia Unknown status NCT02467101
8 Expression of Fas Protein in Skin Biopsies of Participants With Scarring Alopecia Completed NCT00691769
9 Role of Neurogenic Inflammation and Topical 6% Gabapentin Therapy in Symptomatic Scarring Alopecia Completed NCT03346668 Early Phase 1 Topical gabapentin
10 A Proof of Concept, Non-randomized, One Center Study to Explore the Safety and Efficacy of 16 Weeks of Treatment With Ixekizumab in Adult Patients With Lichen Planus and Lichen Planopilaris Recruiting NCT05030415 Early Phase 1 Ixekizumab Auto-Injector
11 Design and Validation of a New Assessment Tool for Lichen Planopilaris, the Boston Grade of Activity in Lichen Planopilaris (Boston GOAL) Active, not recruiting NCT03082560
12 Follicular Revival in Fibrosing Alopecia: Evaluating Use of Micro-needling Active, not recruiting NCT04342091
13 Assessment of the Safety and Efficacy of Intralesional Platelet Rich Plasma in Reducing Scalp Symptoms and Promoting Hair Growth in Frontal Fibrosing Alopecia Not yet recruiting NCT03335228

Search NIH Clinical Center for Frontal Fibrosing Alopecia

Genetic Tests for Frontal Fibrosing Alopecia

Anatomical Context for Frontal Fibrosing Alopecia

Organs/tissues related to Frontal Fibrosing Alopecia:

MalaCards : Skin, Eye, Myeloid, Bone Marrow, T Cells, Neutrophil, Thyroid

Publications for Frontal Fibrosing Alopecia

Articles related to Frontal Fibrosing Alopecia:

(show top 50) (show all 960)
# Title Authors PMID Year
1
Lichen planopilaris treated with a peroxisome proliferator-activated receptor gamma agonist. 53 62
20026843 2009
2
Scarring alopecia and the PPAR-gamma connection. 53 62
19369934 2009
3
Psychosocial burden of frontal fibrosing alopecia: a qualitative interview study. 62
35867867 2022
4
Exploring potential decreasing age of patients with frontal fibrosing alopecia. 62
36034744 2022
5
Eyebrow hair loss as a prognostic factor for frontal fibrosing alopecia. 62
36089939 2022
6
Frontal fibrosing alopecia sparing a dermal melanocytic nevus: a report of two cases of Renbök phenomenon. 62
35842928 2022
7
Menopause, skin and common dermatoses. Part 1: hair disorders. 62
35796569 2022
8
Rapidly increasing incidence and prevalence of lichen planopilaris in an Asian population: A Korean nationwide population-based study. 62
35726744 2022
9
Hair loss patterns in Hispanics with lichen planopilaris. 62
35841343 2022
10
Are Sunscreen Particles Involved in Frontal Fibrosing Alopecia?-A TEM-EDXS Analysis on Formalin-Fixed Paraffin-Embedded Alopecia Biopsies (Pilot Study). 62
36197059 2022
11
IL-17 Expression in the Perifollicular Fibrosis in Biopsies From Lichen Planopilaris. 62
36197049 2022
12
Merkel cell number and distribution, and CD200 expression in patients with lichen planopilaris and discoid lupus erythematosus. 62
36445269 2022
13
Efficacy and safety of oral pioglitazone in the management of lichen planopilaris in comparison with clobetasol: A randomized clinical trial. 62
36169160 2022
14
[Translated article] Coexistence of Vitiligo and Frontal Fibrosing Alopecia: A Case Report and Analysis of Its Physiopathology. 62
36195176 2022
15
Coexistence of vitiligo and frontal fibrosing alopecia: A case report and analysis of its physiopathology. 62
36460362 2022
16
Basal cell carcinoma arising within an alopecic patch of lichen planopilaris. 62
36212898 2022
17
Baricitinib as an effective treatment for lichen planopilaris. 62
36181307 2022
18
Examining the autoimmune aspects of frontal fibrosing alopecia. 62
35904171 2022
19
A Multicenter Descriptive Analysis of 270 Men with Frontal Fibrosing Alopecia and Lichen Planopilaris in the United States. 62
36396001 2022
20
Familial frontal fibrosing alopecia: the first Italian case. 62
36213974 2022
21
Clinical features and treatment outcomes of frontal fibrosing alopecia in men. 62
35726489 2022
22
Comorbidities associated with lichen planopilaris: a case-control study using the All of Us database. 62
36183250 2022
23
The first study on autologous adipose tissue transfer in the treatment of lichen planopilaris. 62
35500148 2022
24
Pseudo-Fringe sign in frontal fibrosing alopecia-like cutaneous lupus erythematosus. 62
35462430 2022
25
The Prevalence of Type IV Hypersensitivity in Patients With Lichen Planopilaris and Frontal Fibrosing Alopecia. 62
36255410 2022
26
Dystrophic xanthomization secondary to lichen planus pigmentosus associated with frontal fibrosing alopecia. 62
36205600 2022
27
Vitamin D deficiency among patients with lichen planopilaris or frontal fibrosing alopecia. 62
35875397 2022
28
A Case of Perifollicular Macular Amyloidosis. 62
36119001 2022
29
Changing spectrum of hair and scalp disorders over the last decade in a tertiary medical centre. 62
36066315 2022
30
Treatment of lichen planopilaris with baricitinib: A retrospective study. 62
35202778 2022
31
A prospective pilot study of narrowband UV-B treatment of lichen planopilaris. 62
35526653 2022
32
Prevalence of lichen planopilaris in the United States: A cross-sectional study of the All of Us research program. 62
35721298 2022
33
'Your hair is your crowning glory': a patient's experience of frontal fibrosing alopecia. 62
35822230 2022
34
Relevant sensitization to diethylamino hydroxybenzoyl hexyl benzoate and fragrances in a patient with frontal fibrosing alopecia and acquired dermal macular hyperpigmentation. 62
35506507 2022
35
Trichoscopy-Derived Hairline Recession Equivalent in Monitoring Frontal Fibrosing Alopecia. 62
36161086 2022
36
Comparison of systemic and topical isotretinoin in the treatment of facial lichen planopilaris: A randomized controlled trial. 62
34982493 2022
37
Drugs targeting epithelial-mesenchymal transition molecules for treatment of lichen planopilaris. 62
35506309 2022
38
The association between frontal fibrosing alopecia, sunscreen, and moisturizers: A systematic review and meta-analysis. 62
35074440 2022
39
Clinical efficacy of mychophenolate mofetil in treating lichen planopilaris. 62
35674693 2022
40
Low-dose oral minoxidil in female patients with lichen planopilaris: Real-life experience. 62
35974439 2022
41
Efficacy, safety, tolerability, and satisfaction of N-acetylcysteine and pentoxifylline in lichen planopilaris patients under treatment with topical clobetasol: A triple arm blinded randomized controlled trial. 62
35703373 2022
42
Frontal Fibrosing Alopecia and Sunscreen Use: A Cross-sectional Study of Actinic Damage. 62
35604235 2022
43
JAK inhibitors in lichen planus: a review of pathogenesis and treatments. 62
35997540 2022
44
Clinicopathological Features of Alopecia With an Emphasis on Etiology and Histopathological Characteristics of Scarring Alopecia. 62
36072194 2022
45
Comorbidities in Patients with Lichen Planopilaris: A Case-Control Study. 62
35983472 2022
46
Lichen Planopilaris Responsive to a Novel Phytoactive Botanical Treatment: A Case Series. 62
35674981 2022
47
Primary cicatricial alopecias are characterized by dysregulation of shared gene expression pathways. 62
35899069 2022
48
Inflammatory complications after hair transplantation: Report of 10 cases. 62
35841210 2022
49
Multiple Clinical Manifestations of Lichenoid Spectrum: A Patient with Frontal Fibrosing Alopecia, Lichen Planus Pigmentosus, and Nail Lichen Planus. 62
35983468 2022
50
Male Frontal Fibrosing Alopecia with Generalized Body Hair Loss. 62
36081439 2022

Variations for Frontal Fibrosing Alopecia

ClinVar genetic disease variations for Frontal Fibrosing Alopecia:

5
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 HEPHL1 NM_001098672.2(HEPHL1):c.3280C>T (p.Arg1094Ter) SNV Uncertain Significance
1690306 GRCh37: 11:93844860-93844860
GRCh38: 11:94111694-94111694

Expression for Frontal Fibrosing Alopecia

Search GEO for disease gene expression data for Frontal Fibrosing Alopecia.

Pathways for Frontal Fibrosing Alopecia

GO Terms for Frontal Fibrosing Alopecia

Sources for Frontal Fibrosing Alopecia

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....