MCID: FRN007
MIFTS: 28

Frontal Lobe Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Frontal Lobe Neoplasm

MalaCards integrated aliases for Frontal Lobe Neoplasm:

Name: Frontal Lobe Neoplasm 12 15
Neoplasm of Frontal Lobe 12 71
Malignant Neoplasm of Frontal Lobe 12
Tumor of Frontal Lobe 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12016
ICD9CM 34 191.1
NCIt 49 C5572
SNOMED-CT 67 93807001
ICD10 32 C71.1
UMLS 71 C0153635 C1263886

Summaries for Frontal Lobe Neoplasm

MalaCards based summary : Frontal Lobe Neoplasm, also known as neoplasm of frontal lobe, is related to adult brain stem glioma and central nervous system rhabdomyosarcoma. An important gene associated with Frontal Lobe Neoplasm is MGMT (O-6-Methylguanine-DNA Methyltransferase), and among its related pathways/superpathways are Proteoglycans in cancer and Colorectal Cancer Metastasis. Affiliated tissues include brain and eye, and related phenotypes are craniofacial and no phenotypic analysis

Related Diseases for Frontal Lobe Neoplasm

Diseases related to Frontal Lobe Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 290)
# Related Disease Score Top Affiliating Genes
1 adult brain stem glioma 10.4 MGMT IDH1
2 central nervous system rhabdomyosarcoma 10.4 MGMT IDH1
3 spinal cord astrocytoma 10.4 MGMT IDH1
4 temporal lobe neoplasm 10.4 MGMT IDH1
5 childhood oligodendroglioma 10.4 MGMT IDH1
6 glioblastoma classical subtype 10.4 MGMT IDH1
7 extraventricular neurocytoma 10.3 SYP IDH1
8 angiocentric glioma 10.2 SYP IDH1
9 tanycytic ependymoma 10.2 SYP IDH1
10 vulva basal cell carcinoma 10.2 SYP MYC
11 lung acinar adenocarcinoma 10.2 MYC EGFR
12 lymphoepithelioma-like thymic carcinoma 10.2 SYP IDH1
13 breast hemangioma 10.2 TP53 IDH1
14 desmoplastic infantile ganglioglioma 10.1 SYP MYCN
15 papillary squamous carcinoma 10.1 SYP EGFR
16 adult astrocytic tumour 10.1 TP53 IDH1
17 anal carcinoma in situ 10.1 TP53 MYC
18 malignant ependymoma 10.1 MGMT IDH1 EGFR
19 intraductal breast neoplasm 10.1 TP53 IDH1
20 b cell prolymphocytic leukemia 10.1 TP53 MYC
21 cervical neuroblastoma 10.1 SYP MYCN
22 low-grade astrocytoma 10.1 TP53 IDH1
23 esophageal basaloid squamous cell carcinoma 10.1 TP53 EGFR
24 suppressor of tumorigenicity 3 10.1 TP53 MYC
25 esophagus verrucous carcinoma 10.1 TP53 EGFR
26 nodular medulloblastoma 10.1 SYP MYCN
27 juvenile astrocytoma 10.1 TP53 IDH1
28 juvenile pilocytic astrocytoma 10.1 SYP MGMT IDH1
29 soft tissue sarcoma 10.1 TP53 EGFR
30 glomangiosarcoma 10.1 TP53 SYP
31 breast malignant phyllodes tumor 10.1 TP53 EGFR
32 laryngeal neuroendocrine tumor 10.0 TP53 SYP
33 mature teratoma 10.0 TP53 SYP
34 sarcomatoid transitional cell carcinoma 10.0 TP53 SYP
35 primary peritoneal carcinoma 10.0 TP53 EGFR
36 anal squamous cell carcinoma 10.0 TP53 MGMT
37 biliary tract benign neoplasm 10.0 TP53 SYP
38 gemistocytic astrocytoma 10.0 TP53 MGMT IDH1
39 bone squamous cell carcinoma 10.0 TP53 EGFR
40 megaesophagus 10.0 TP53 MYC
41 glomangiomatosis 10.0 TP53 SYP
42 papillary adenoma 10.0 TP53 SYP
43 microglandular adenosis 10.0 TP53 EGFR
44 vulvar disease 9.9 TP53 EGFR
45 laryngeal benign neoplasm 9.9 TP53 EGFR
46 familial retinoblastoma 9.9 TP53 MYCN
47 pituitary carcinoma 9.9 TP53 MGMT
48 central nervous system lymphoma 9.9 TP53 MYC MGMT
49 malignant melanocytic neoplasm of the peripheral nerve sheath 9.9 SYP ENO2
50 chordoid glioma 9.9 TP53 SYP

Graphical network of the top 20 diseases related to Frontal Lobe Neoplasm:



Diseases related to Frontal Lobe Neoplasm

Symptoms & Phenotypes for Frontal Lobe Neoplasm

MGI Mouse Phenotypes related to Frontal Lobe Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.55 EGFR ENO2 MYC MYCN TP53
2 no phenotypic analysis MP:0003012 9.35 EGFR MGMT MYC MYCN TP53
3 respiratory system MP:0005388 9.1 EGFR ENO2 IDH1 MGMT MYCN TP53

Drugs & Therapeutics for Frontal Lobe Neoplasm

Search Clinical Trials , NIH Clinical Center for Frontal Lobe Neoplasm

Genetic Tests for Frontal Lobe Neoplasm

Anatomical Context for Frontal Lobe Neoplasm

MalaCards organs/tissues related to Frontal Lobe Neoplasm:

40
Brain, Eye

Publications for Frontal Lobe Neoplasm

Articles related to Frontal Lobe Neoplasm:

# Title Authors PMID Year
1
Do nurses risk underestimating the problems of patients with frontal lobe neoplasms? 61
21601523 2012
2
Palisades in primary cerebral neuroblastoma simulating so-called polar spongioblastoma. A light and electron microscopical study of an adult case. 61
2436498 1987

Variations for Frontal Lobe Neoplasm

Expression for Frontal Lobe Neoplasm

Search GEO for disease gene expression data for Frontal Lobe Neoplasm.

Pathways for Frontal Lobe Neoplasm

GO Terms for Frontal Lobe Neoplasm

Biological processes related to Frontal Lobe Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.8 TP53 TOP2A MYCN MYC EGFR
2 negative regulation of apoptotic process GO:0043066 9.73 TP53 MYC MGMT EGFR
3 cellular response to DNA damage stimulus GO:0006974 9.67 TP53 TOP2A MYC MGMT
4 response to oxidative stress GO:0006979 9.5 TP53 IDH1 EGFR
5 chromosome organization GO:0051276 9.48 TP53 MYC
6 response to gamma radiation GO:0010332 9.46 TP53 MYC
7 response to organic cyclic compound GO:0014070 9.43 MGMT IDH1 EGFR
8 DNA ligation GO:0006266 9.16 TOP2A MGMT
9 cellular response to drug GO:0035690 9.13 TP53 MYC EGFR
10 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.8 TP53 MYCN EGFR

Sources for Frontal Lobe Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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