MCID: FRN005
MIFTS: 15

Frontal Sinus Squamous Cell Carcinoma

Categories: Cancer diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Frontal Sinus Squamous Cell Carcinoma

MalaCards integrated aliases for Frontal Sinus Squamous Cell Carcinoma:

Name: Frontal Sinus Squamous Cell Carcinoma 12 15 74
Epidermoid Carcinoma of the Frontal Sinus 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2441
NCIt 51 C6067
UMLS 74 C1333646

Summaries for Frontal Sinus Squamous Cell Carcinoma

Disease Ontology : 12 A squamous cell carcinoma that is located in the frontal sinus.

MalaCards based summary : Frontal Sinus Squamous Cell Carcinoma, also known as epidermoid carcinoma of the frontal sinus, is related to squamous cell carcinoma and cholesteatoma of middle ear, and has symptoms including pain and rhinorrhea. An important gene associated with Frontal Sinus Squamous Cell Carcinoma is ANO1 (Anoctamin 1). Affiliated tissues include skin and the frontal sinus.

Related Diseases for Frontal Sinus Squamous Cell Carcinoma

Diseases related to Frontal Sinus Squamous Cell Carcinoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 squamous cell carcinoma 10.3
2 cholesteatoma of middle ear 10.1

Symptoms & Phenotypes for Frontal Sinus Squamous Cell Carcinoma

UMLS symptoms related to Frontal Sinus Squamous Cell Carcinoma:


pain, rhinorrhea

Drugs & Therapeutics for Frontal Sinus Squamous Cell Carcinoma

Search Clinical Trials , NIH Clinical Center for Frontal Sinus Squamous Cell Carcinoma

Genetic Tests for Frontal Sinus Squamous Cell Carcinoma

Anatomical Context for Frontal Sinus Squamous Cell Carcinoma

MalaCards organs/tissues related to Frontal Sinus Squamous Cell Carcinoma:

42
Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Frontal Sinus Squamous Cell Carcinoma:

20
The Frontal Sinus

Publications for Frontal Sinus Squamous Cell Carcinoma

Articles related to Frontal Sinus Squamous Cell Carcinoma:

# Title Authors Year
1
Primary frontal sinus squamous cell carcinoma in a dog treated with surgical excision. ( 28042160 )
2017
2
Superior orbitectomy and chemotherapy in a dog with frontal sinus squamous cell carcinoma: a case report and review of the literature. ( 28396780 )
2017
3
Primary frontal sinus squamous cell carcinoma in three dogs treated with piroxicam combined with carboplatin or toceranib. ( 22236048 )
2012
4
Epidermoid carcinoma of the frontal sinus secondary to cholesteatoma. ( 855080 )
1977

Variations for Frontal Sinus Squamous Cell Carcinoma

Cosmic variations for Frontal Sinus Squamous Cell Carcinoma:

9 (show all 49)
# Cosmic Mut ID Gene Symbol COSMIC Disease Classification
(Primary site, Site subtype, Primary histology, Histology subtype)
Mutation CDS Mutation AA GRCh38 Location Conf
1 COSM10704 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.844C>T p.R282W 17:7673776-7673776 0
2 COSM43881 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.757A>T p.T253S 17:7674206-7674206 0
3 COSM44097 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.530C>T p.P177L 17:7675082-7675082 0
4 COSM43555 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.736A>G p.M246V 17:7674227-7674227 0
5 COSM10660 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.818G>A p.R273H 17:7673802-7673802 0
6 COSM43962 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.805A>G p.S269G 17:7673815-7673815 0
7 COSM10648 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.524G>A p.R175H 17:7675088-7675088 0
8 COSM10659 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.817C>T p.R273C 17:7673803-7673803 0
9 COSM44338 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.845G>A p.R282Q 17:7673775-7673775 0
10 COSM10647 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.404G>T p.C135F 17:7675208-7675208 0
11 COSM45046 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.542G>C p.R181P 17:7675070-7675070 0
12 COSM10654 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.637C>T p.R213* 17:7674894-7674894 0
13 COSM10651 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.530C>G p.P177R 17:7675082-7675082 0
14 COSM27173 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.360G>T p.K120N 17:7676009-7676009 0
15 COSM44312 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.511G>A p.E171K 17:7675101-7675101 0
16 COSM1610880 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.97-1G>T p.? 17:7676273-7676273 0
17 COSM10656 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.742C>T p.R248W 17:7674221-7674221 0
18 COSM10650 TP53 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.529C>T p.P177S 17:7675083-7675083 0
19 COSM4531793 SUZ12 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.1825G>A p.G609R 17:31996828-31996828 0
20 COSM6973197 SUZ12 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.1639G>C p.E547Q 17:31995607-31995607 0
21 COSM6441198 RB1 upper aerodigestive tract,sinus,carcinoma,undifferentiated carcinoma c.940-1G>A p.? 13:48367493-48367493 0
22 COSM6973188 NSD1 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.5074C>G p.H1692D 5:177260096-177260096 0
23 COSM581 NRAS upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.181C>G p.Q61E 1:114713909-114713909 0
24 COSM6973198 NOTCH3 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2641G>A p.G881S 19:15181727-15181727 0
25 COSM6973185 NOTCH2 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.5458G>C p.D1820H 1:119920250-119920250 0
26 COSM120958 NFE2L2 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.235G>C p.E79Q 2:177234082-177234082 0
27 COSM6973195 LATS2 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2827G>C p.E943Q 13:20975310-20975310 0
28 COSM521 KRAS upper aerodigestive tract,sinus,carcinoma,undifferentiated carcinoma c.35G>A p.G12D 12:25245350-25245350 0
29 COSM551 KRAS upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.182A>C p.Q61P 12:25227342-25227342 0
30 COSM518 KRAS upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.34G>C p.G12R 12:25245351-25245351 0
31 COSM500 HRAS upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.182A>C p.Q61P 11:533874-533874 0
32 COSM487 HRAS upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.37G>A p.G13S 11:534286-534286 0
33 COSM6973196 GRIN2A upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2008T>A p.F670I 16:9822424-9822424 0
34 COSM6960306 ETV1 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.755C>G p.P252R 7:13931549-13931549 0
35 COSM6960303 EPHA3 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2945C>T p.P982L 3:89479495-89479495 0
36 COSM6942122 CDK12 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2045C>T p.P682L 17:39490670-39490670 0
37 COSM5967148 ARID1A upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.3446C>G p.S1149* 1:26772539-26772539 0
38 COSM1610881 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.97-1G>T p.? 17:7676273-7676273 0
39 COSM3937615 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.360G>T p.K120N 17:7676009-7676009 0
40 COSM1610882 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.97-1G>T p.? 17:7676273-7676273 0
41 COSM3717684 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.97-1G>T p.? 17:7676273-7676273 0
42 COSM2744988 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.360G>T p.K120N 17:7676009-7676009 0
43 COSM3717685 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.97-1G>T p.? 17:7676273-7676273 0
44 COSM6960305 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.635C>G p.P212R 7:13931549-13931549 0
45 COSM6973189 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.5074C>G p.H1692D 5:177260096-177260096 0
46 COSM2744989 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.360G>T p.K120N 17:7676009-7676009 0
47 COSM6973194 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2827G>C p.E943Q 13:20975310-20975310 0
48 COSM6973199 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.2641G>A p.G881S 19:15181727-15181727 0
49 COSM2744987 upper aerodigestive tract,sinus,carcinoma,squamous cell carcinoma c.360G>T p.K120N 17:7676009-7676009 0

Expression for Frontal Sinus Squamous Cell Carcinoma

Search GEO for disease gene expression data for Frontal Sinus Squamous Cell Carcinoma.

Pathways for Frontal Sinus Squamous Cell Carcinoma

GO Terms for Frontal Sinus Squamous Cell Carcinoma

Sources for Frontal Sinus Squamous Cell Carcinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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