Aliases & Classifications for Frozen Shoulder

MalaCards integrated aliases for Frozen Shoulder:

Name: Frozen Shoulder 12 15 63 73
Bursitis 44 73
Adhesive Capsulitis of Shoulder 12
Adhesions-Capsulitis,shoulder 12


External Ids:

Disease Ontology 12 DOID:14188
ICD10 33 M75.0
ICD9CM 35 726.0
MeSH 44 D002062
UMLS 73 C0311223

Summaries for Frozen Shoulder

PubMed Health : 63 About frozen shoulder: If you have what is known as frozen shoulder, your shoulder gradually becomes painful and stiff without there being any clear cause. It most commonly affects people around the age of 50.Frozen shoulder will usually get better without treatment. It can take several months for the pain to disappear completely, though, and a lot longer until you can move your shoulder normally again. But a number of treatments can help to temporarily relieve the symptoms.

MalaCards based summary : Frozen Shoulder, also known as bursitis, is related to joint disorders and osteoarthritis, and has symptoms including arthralgia, back pain and metatarsalgia. An important gene associated with Frozen Shoulder is ASIC3 (Acid Sensing Ion Channel Subunit 3), and among its related pathways/superpathways are Ion channel transport and Development Endothelin-1/EDNRA signaling. The drugs Lidocaine and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include testes, breast and bone, and related phenotypes are nervous system and hearing/vestibular/ear

Wikipedia : 76 Adhesive capsulitis (also known as frozen shoulder) is a painful and disabling disorder of unclear cause... more...

Related Diseases for Frozen Shoulder

Diseases related to Frozen Shoulder via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 48)
# Related Disease Score Top Affiliating Genes
1 joint disorders 31.5 IL1B MMP3
2 osteoarthritis 29.0 GDF5 IL1B MMP3
3 bursitis 12.5
4 olecranon bursitis 12.5
5 achilles bursitis 12.3
6 gonococcal bursitis 12.0
7 tibial collateral ligament bursitis 12.0
8 specific bursitis often of occupational origin 11.9
9 fibular collateral ligament bursitis 11.9
10 pes anserinus tendinitis or bursitis 11.8
11 calcific tendinitis 11.4
12 dupuytren contracture 11.0
13 overuse syndrome 10.9
14 repetitive motion disorders 10.9
15 repetitive stress injuries 10.9
16 tendinitis 10.2
17 spondylolisthesis 10.2 GDF5 MMP3
18 corneal ulcer 10.2 IL1B MMP3
19 corneal edema 10.1 IL1B MMP3
20 diabetes mellitus 10.1
21 cervicitis 10.0
22 pelvic organ prolapse 10.0 COL1A1 MMP3
23 bone inflammation disease 9.9 IL1B MMP3
24 epicondylitis 9.9
25 aortic aneurysm, familial abdominal, 1 9.8 IL1B MMP3
26 breast cancer 9.8
27 aging 9.8
28 anxiety 9.8
29 arthritis 9.8
30 hypothyroidism 9.8
31 pulmonary tuberculosis 9.8
32 gallbladder cancer 9.8
33 hyperthyroidism 9.8
34 neuronitis 9.8
35 septic arthritis 9.8
36 influenza 9.8
37 depression 9.8
38 aneurysm 9.8
39 autonomic dysfunction 9.8
40 endotheliitis 9.8
41 bone development disease 9.7 COL1A1 GDF5
42 bone deterioration disease 9.6 GDF5 IL1B MMP3
43 bone structure disease 9.6 GDF5 IL1B MMP3
44 synovitis 9.6 IL1B MMP3
45 osteogenesis imperfecta, type vi 9.4 COL1A1 CTNNB1
46 hydrarthrosis 9.3 ASIC2 ASIC3 IL1B MMP3
47 bone disease 9.3 COL1A1 GDF5 IL1B
48 osteoporosis 8.5 COL1A1 CTNNB1 IL1B MMP3

Comorbidity relations with Frozen Shoulder via Phenotypic Disease Network (PDN):

Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Frozen Shoulder:

Diseases related to Frozen Shoulder

Symptoms & Phenotypes for Frozen Shoulder

UMLS symptoms related to Frozen Shoulder:

arthralgia, back pain, metatarsalgia, muscle cramp, sciatica, myalgia, bursal pain, bursal tenderness

MGI Mouse Phenotypes related to Frozen Shoulder:

# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.5 ASIC1 ASIC2 ASIC3 COL1A1 CTNNB1 IL1B
2 hearing/vestibular/ear MP:0005377 9.46 ASIC2 ASIC3 COL1A1 CTNNB1
3 skeleton MP:0005390 9.02 COL1A1 CTNNB1 GDF5 IL1B MMP3

Drugs & Therapeutics for Frozen Shoulder

PubMedHealth treatment related to Frozen Shoulder: 63

The healing process takes time and cannot be sped up. But there are various pain relief options and ways to improve shoulder mobility. During the first phase of frozen shoulder, the focus is on pain relief. Afterwards, the main goal of treatment is to help you move your shoulder more.Common treatments for pain relief include the following:Application of heat or cold to the jointAnti-inflammatory painkillers like ibuprofen (tablets or cream)Steroids (tablets or injection in shoulder)Hydrodilatation / Arthrographic distension (injection of a solution to improve joint flexibility)Stretching exercises and physiotherapy can be used to improve joint mobility. Surgery is rarely used in the treatment of frozen shoulder because it gets better on its own, and the procedure carries the usual risks associated with surgery and the use of anesthetics. This also applies to mobilization of the joint under general anesthetic.

Drugs for Frozen Shoulder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 47)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Not Applicable 137-58-6 3676
Methylprednisolone Approved, Vet_approved Phase 4,Not Applicable 83-43-2 6741
Prednisolone Approved, Vet_approved Phase 4,Not Applicable 50-24-8 5755
Ropivacaine Approved Phase 4,Not Applicable 84057-95-4 71273 175805
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
6 Anesthetics Phase 4,Phase 3,Not Applicable
7 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable
8 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
9 Anesthetics, Local Phase 4,Phase 3,Not Applicable
10 Anti-Arrhythmia Agents Phase 4,Phase 3,Not Applicable
11 Diuretics, Potassium Sparing Phase 4,Phase 3,Not Applicable
12 Sodium Channel Blockers Phase 4,Phase 3,Not Applicable
13 Antiemetics Phase 4,Not Applicable
14 Anti-Inflammatory Agents Phase 4,Phase 3,Not Applicable
15 Antineoplastic Agents, Hormonal Phase 4,Not Applicable
16 Autonomic Agents Phase 4,Not Applicable
17 Gastrointestinal Agents Phase 4,Not Applicable
18 glucocorticoids Phase 4,Phase 3,Not Applicable
19 Hormone Antagonists Phase 4,Phase 3,Not Applicable
20 Hormones Phase 4,Phase 3,Not Applicable
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 3,Not Applicable
22 Methylprednisolone acetate Phase 4,Not Applicable
23 Methylprednisolone Hemisuccinate Phase 4,Not Applicable
24 Neuroprotective Agents Phase 4,Not Applicable
25 Pharmaceutical Solutions Phase 4,Phase 3
26 Prednisolone acetate Phase 4,Not Applicable
27 Prednisolone hemisuccinate Phase 4,Not Applicable
28 Prednisolone phosphate Phase 4,Not Applicable
29 Protective Agents Phase 4,Not Applicable
30 Analgesics Phase 4,Not Applicable
31 Analgesics, Non-Narcotic Phase 4
32 Anesthetics, General Phase 4
33 Anesthetics, Inhalation Phase 4
Triamcinolone Approved, Vet_approved Phase 3,Not Applicable 124-94-7 31307
35 Immunosuppressive Agents Phase 3,Not Applicable
36 triamcinolone acetonide Phase 3,Not Applicable
37 Triamcinolone diacetate Phase 3,Not Applicable
38 Triamcinolone hexacetonide Phase 3,Not Applicable
Prilocaine Approved Not Applicable 721-50-6 4906
Menthol Approved Not Applicable 2216-51-5 16666
Hyaluronic acid Approved, Vet_approved Not Applicable 9004-61-9 53477741
Bupivacaine Approved, Investigational Not Applicable 2180-92-9, 38396-39-3 2474
Vitamin A Approved, Nutraceutical, Vet_approved Not Applicable 11103-57-4, 68-26-8 445354
44 Retinol palmitate Not Applicable
45 Adjuvants, Immunologic Not Applicable
46 Viscosupplements Not Applicable
47 retinol Nutraceutical Not Applicable

Interventional clinical trials:

(show top 50) (show all 54)
# Name Status NCT ID Phase Drugs
1 Arthroscopy and Manipulation vs a Home Therapy Program in the Treatment of Adhesive Capsulitis Completed NCT00160784 Phase 4
2 Effectiveness of an Oxygen-nitrous Oxide Mixture During Physical Therapy for Frozen Shoulder Completed NCT01087229 Phase 4 equimolar oxygen-nitrous oxide mixture;Placebo
3 An RCT in Treatment of Adhesive Capsulitis Arthrographic Joint Distention With Local Anesthetic Alone Completed NCT02001740 Phase 4 Triamcinalone (steroid) and lidocaine
4 Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment Recruiting NCT02283996 Phase 4 Depot Methylprednisolone
5 Spray vs EMLA Cream on Pain During Intra-articular Injection Recruiting NCT03484832 Phase 4 EMLA Cream
6 The Effect of 3 Ropivacaine Suprascapular Nerve Blocks in Subacute Adhesive Capsulitis: a Randomized Controlled Trial Recruiting NCT02944526 Phase 4 Ropivacaine Monohydrochloride;Placebo - Concentrate
7 Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis Recruiting NCT03479502 Phase 4 Methylprednisolone Injectable Product;Doxycycline Injection
8 Efficacy and Tolerance of Ultrasound-guided Needling and Lavage of Calcific Tendinitis of the Rotator Cuff Performed With or Without Subacromial Corticosteroid Injection Active, not recruiting NCT02403856 Phase 4 Sodium Chloride 0.9%;Methylprednisolone acetate
9 Shoulder Adhesive Capsulitis and Ambulatory Continuous Interscalene Nerve Blocks Terminated NCT00875862 Phase 4
10 Treatment Study of Frozen Shoulder: Corticosteroid Injection in Joint Versus Wait and See Policy Unknown status NCT01570985 Phase 3 Triamcinolone Acetonide;Triamcinolone Acetonide
11 Scientifically Merged Acupuncture and Robot-assisted Technology (SMART) for Rehabilitation of Frozen Shoulder Syndrome: Second-year Project-Comparison of Robot and Conventional Physiotherapy (Including Preliminary Test on Healthy Volunteers) Unknown status NCT02206542 Phase 2
12 Bee Venom Acupuncture for the Treatment of Frozen Shoulder Completed NCT01526031 Phase 2
13 Prediction Frozen Shoulder Validation Completed NCT01157221 Phase 1, Phase 2
14 Clinical Study for the Treatment of Adhesive Capsulitis of the Shoulder Completed NCT02006719 Phase 2
15 AA4500 for the Treatment of Adhesive Capsulitis of the Shoulder Completed NCT01483963 Phase 2
16 Collagenase in the Treatment of Adhesive Capsulitis (Frozen Shoulder) Withdrawn NCT00261196 Phase 2 Collagenase
17 Quantum Spectrum Radiation Emitter for Adhesive Capsulitis Unknown status NCT02133833 Phase 1
18 The Study of Different Treatment Programs for Patients With Frozen Shoulder Unknown status NCT01249040 Not Applicable
19 Mobilization Techniques in Patients With Frozen Shoulder: a Randomized Multiple-Treatment Trial Unknown status NCT00172601 Not Applicable
20 Surgery or Capsular Distention With Steroid in the Treatment of Primary Frozen Shoulder? Unknown status NCT01029600 Not Applicable
21 Acupuncture for Treatment of Frozen Shoulder Syndrome Unknown status NCT02076308 Not Applicable
22 Corticosteroids and / or Arthrographic Distention in the Treatment of Adhesive Capsulitis Unknown status NCT01983527 Not Applicable Intra-articular corticosteroid Depo Medrol
23 Indwelling Interscalene Nerve Catheters in Surgical Management of Idiopathic Adhesive Capsulitis Unknown status NCT01606332 Not Applicable
24 Natural Course of Adhesive Capsulitis of Hip Unknown status NCT01449227
25 Prevalence of Unknown and Known Diabetes in Patients With Frozen Shoulder Completed NCT01978886
26 Clinical Trial on Frozen Shoulder Using Bilateral Shoulder Radiography in Different Position Completed NCT02169206 Not Applicable
27 Hydrodilatation Versus Arthroscopic Capsular Release for Frozen Shoulder Completed NCT03463538 Not Applicable
28 Effect of Combined Intra-articular Injection of Lidocaine Plus Physiotherapy in Treatment of Frozen Shoulder Completed NCT01817348 Not Applicable
29 Translational Manipulation Under Interscalene Block for Adhesive Capsulitis of the Shoulder (TMACS) Completed NCT03090555 Not Applicable
30 Prevalence of Impaired Glucose Tolerance (IGT) in Patients With Frozen Shoulder Completed NCT00926094
31 Rotator Interval and Intra-articular Corticosteroid Injection for Frozen Shoulder Completed NCT00840229 Not Applicable Triamcinolone hexacetonide;Triamcinolone hexacetonide
32 Ultrasound-Guided Glenohumeral Steroid Injection Completed NCT02461368 Not Applicable Glenohumeral triamcinolone injection by anterior approach;Glenohumeral triamcinolone injection by posterior approach;Glenohumeral lidocaine injection by anterior approach;Glenohumeral lidocaine injection by posterior approach;Glenohumeral normal saline injection by anterior approach;Glenohumeral normal saline injection by posterior approach;Glenohumeral Omnipaque injection by anterior approach;Glenohumeral Omnipaque injection by posterior approach
33 Correlating Clinical Disease State With Color Doppler Ultrasound Completed NCT00761943
34 Domiciliary Physiotherapy in Women Undergoing Treatment for Breast Cancer Radiation Completed NCT01940107 Not Applicable
35 Validation of a Kinematic Functional Shoulder Score Including Only Essential Movements Completed NCT01431417
36 Massage in Treating Painful Shoulder Completed NCT01307826 Not Applicable
37 Noxipoint Therapy Versus Standard Physical Therapy Using Electrical Stimulation for Chronic Pain Completed NCT01578148 Not Applicable
38 Intra-articular Injection of Allogeneic Platelet Rich Plasma (PRP) for Adhesive Capsulitis Completed NCT01458691 Not Applicable
39 Comparative Analysis of Intra-articular Injection of Steroid and/or Sodium Hyaluronate in Adhesive Capsulitis Completed NCT01144533 Not Applicable
40 Validation of a Score for Shoulder Function Evaluation Based on Movement Analysis Completed NCT01281085
41 Trial of Resistance and Endurance Exercise in Amyotrophic Lateral Sclerosis (ALS) Completed NCT01521728 Not Applicable
42 Epidemiology and Outcomes of Upper Limb Surgery: Analysis of Routine Data Completed NCT03573765
43 Effect of Ultrasound-guided Suprascapular Nerve Block Versus Intra-articular Corticosteroid Injection for Frozen Shoulder Recruiting NCT03515278 Not Applicable
44 A Central Nervous System Focused Treatment Approach for Frozen Shoulder Recruiting NCT03320200 Not Applicable
45 Manipulation Under Anesthesia Versus Arthroscopic Capsular Release in the Treatment of Adhesive Capsulitis Recruiting NCT01961219 Not Applicable
46 Post-operative Mobilisation After Rotator Cuff Repair Recruiting NCT02943005 Not Applicable
47 Formal Physical Therapy (PT) vs. Home PT for Adhesive Capsulitis Active, not recruiting NCT03049787 Not Applicable
48 Pulsed Radiofrequency for Frozen Shoulder Chronic Pain (PRFFSCP) Not yet recruiting NCT03456531 Not Applicable NSAIDs "ibubrofen,Aspirin"
49 Extracorporeal Shock Wave Therapy on Diabetes Related Frozen Shoulder Not yet recruiting NCT03185078 Not Applicable
50 Efficacy of Manual Therapy and Exercise in Patients With Shoulder Adhesive Capsulitis. A Randomized Clinical Trial. Not yet recruiting NCT02976974 Not Applicable

Search NIH Clinical Center for Frozen Shoulder

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cochrane evidence based reviews: bursitis

Genetic Tests for Frozen Shoulder

Anatomical Context for Frozen Shoulder

MalaCards organs/tissues related to Frozen Shoulder:

Testes, Breast, Bone, Endothelial, Skin, Heart

Publications for Frozen Shoulder

Articles related to Frozen Shoulder:

(show top 50) (show all 451)
# Title Authors Year
Ultrasound measurements of axillary recess capsule thickness in unilateral frozen shoulder: study of correlation with MRI measurements. ( 29770850 )
Comparison of Therapeutic Effectiveness Between Shoulder Distention Arthrography With Translation Mobilization and Distention Arthrography Alone in Patients With Frozen Shoulder. ( 29560327 )
Comments on article by Tsvieli et al.: manipulation under anaesthetic for frozen shoulder using Codman's paradox: a safe and early return of function. ( 29460156 )
Clinical outcome of arthroscopic capsular release for frozen shoulder: essential technical points in 255 patients. ( 29548325 )
Manipulation Under Anesthesia Thaws Frozen Shoulder. ( 29946670 )
Comparative Efficacy of Intra-Articular Steroid Injection and Distension in Patients With Frozen Shoulder: A Systematic Review and Network Meta-Analysis. ( 29420999 )
Platelet-rich plasma injection in the treatment of frozen shoulder: A randomized controlled trial with 6-month follow-upa8c. ( 29932415 )
Pectoral nerves 1 block is effective for silent manipulation of frozen shoulder. ( 29121546 )
Short-term Clinical Results of Manipulation Under Ultrasound-Guided Brachial Plexus Block in Patients with Idiopathic Frozen Shoulder and Diabetic Secondary Frozen Shoulder. ( 29619123 )
Arthroscopic Coracohumeral Ligament Release for Patients With Frozen Shoulder. ( 29379707 )
Outcomes of arthroscopic capsular release for the diabetic frozen shoulder in Asian patients. ( 29463205 )
A pragmatic regional interdependence approach to primary frozen shoulder: a retrospective case series. ( 29686485 )
Bilateral Arm-Abduction Shoulder Radiography to Determine the Involvement of the Scapulothoracic Motion in Frozen Shoulder. ( 29911140 )
Comparative proteome analysis of the capsule from patients with frozen shoulder. ( 29784595 )
A randomized controlled trial of arthroscopic capsular release versus hydrodilatation in the treatment of primary frozen shoulder. ( 29798823 )
Activity- vs. structural-oriented treatment approach for frozen shoulder: a randomized controlled trial. ( 28081633 )
Should Patients With Frozen Shoulder Be Screened for Diabetes Mellitus? ( 28812038 )
Clinical correlation of metabolic parameters on (18)F-FDG PET/CT in idiopathic frozen shoulder. ( 28168397 )
The immediate effect of muscle release intervention on muscle activity and shoulder kinematics in patients with frozen shoulder: a cross-sectional, exploratory study. ( 29183307 )
Manipulation under anaesthetic for frozen shoulder using Codman's paradox: a safe and early return of function. ( 28699020 )
Effects of Messages Delivered by Mobile Phone on Increasing Compliance With Shoulder Exercises Among Patients With a Frozen Shoulder. ( 28632975 )
United Kingdom Frozen Shoulder Trial (UK FROST), multi-centre, randomised, 12 month, parallel group, superiority study to compare the clinical and cost-effectiveness of Early Structured Physiotherapy versus manipulation under anaesthesia versus arthroscopic capsular release for patients referred to secondary care with a primary frozen shoulder: study protocol for a randomised controlled trial. ( 29273079 )
Very High Prevalence of Frozen Shoulder in Patients With Type 1 Diabetes of a8Y45 Years' Duration: The Dialong Shoulder Study. ( 28219686 )
Use of Pain Neuroscience Education, Tactile Discrimination, and Graded Motor Imagery in an Individual With Frozen Shoulder. ( 29257926 )
Predicting outcome in frozen shoulder (shoulder capsulitis) in presence of comorbidity as measured with subjective health complaints and neuroticism. ( 28865441 )
Commentary on Horst R et al. Activity- vs. structural-oriented treatment approach for frozen shoulder: a randomized controlled trial. ( 28466685 )
Prevalence and Determinants of Frozen Shoulder in Patients with Diabetes: A Single Center Experience from Pakistan. ( 29018641 )
Effectiveness of Glenohumeral Joint Dilatation for Treatment of Frozen Shoulder: A Systematic Review and Meta-analysis of Randomized Controlled Trials. ( 28874727 )
Translational manipulation under anesthesia for patients with frozen shoulder: a case series study with five-year health care utilization and post-manipulative arthroscopic findings. ( 29449769 )
Indications for hydrodilatation for frozen shoulder. ( 29218231 )
Physical therapy in the management of frozen shoulder. ( 29242941 )
Randomized controlled trial of supervised physiotherapy versus a home exercise program after hydrodilatation for the management of primary frozen shoulder. ( 28318848 )
The Effect of Corticosteroid Injection Into Rotator Interval for Early Frozen Shoulder: A Randomized Controlled Trial. ( 29268022 )
Review of diabetic frozen shoulder. ( 29094212 )
Comparative efficacy of intra-articular steroid injection and distension in patients with frozen shoulder: a systematic review and network meta-analysis. ( 28899826 )
The colonisation of the glenohumeral joint by Propionibacterium acnes is not associated with frozen shoulder but is more likely to occur after an injection into the joint. ( 28768784 )
Thawing frozen shoulder by steroid injection. ( 28142344 )
Manipulation under anesthesia versus physiotherapy treatment in stage two of a frozen shoulder: a study protocol for a randomized controlled trial. ( 29020962 )
Alarmins in Frozen Shoulder: A Molecular Association Between Inflammation and Pain. ( 29190116 )
The effectiveness of ultrasound guided hydrodistension and physiotherapy in the treatment of frozen shoulder/adhesive capsulitis in primary care: a single centre service evaluation. ( 28932287 )
Mobile Phone-Supported Physiotherapy for Frozen Shoulder: Feasibility Assessment Based on a Usability Study. ( 28729234 )
A Study of IL-1I^, MMP-3, TGF-I^1, and GDF5 Polymorphisms and Their Association with Primary Frozen Shoulder in a Chinese Han Population. ( 28676856 )
Development and preclinical trials of a wire-driven end effector device for frozen shoulder treatment. ( 29199363 )
Molecular biology of frozen shoulder-induced limitation of shoulder joint movements. ( 28616048 )
Intra-articular Steroid Injection for Frozen Shoulder: A Systematic Review and Meta-analysis of Randomized Controlled Trials With Trial Sequential Analysis. ( 28298050 )
Frozen shoulder and risk of cancer: a population-based cohort study. ( 28524156 )
Recurrence of frozen shoulder after manipulation under anaesthetic (MUA): the results of repeating the MUA. ( 28566402 )
Frozen shoulder - A prospective randomized clinical trial. ( 28567343 )
Does ultrasound therapy add to the effects of exercise and mobilization in frozen shoulder? A pilot randomized double-blind clinical trial. ( 29037627 )

Variations for Frozen Shoulder

Expression for Frozen Shoulder

Search GEO for disease gene expression data for Frozen Shoulder.

Pathways for Frozen Shoulder

GO Terms for Frozen Shoulder

Biological processes related to Frozen Shoulder according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 ion transmembrane transport GO:0034220 9.67 ASIC1 ASIC2 ASIC3
2 sodium ion transport GO:0006814 9.61 ASIC1 ASIC2 ASIC3
3 sodium ion transmembrane transport GO:0035725 9.58 ASIC1 ASIC2 ASIC3
4 cellular response to mechanical stimulus GO:0071260 9.54 COL1A1 IL1B
5 cation transport GO:0006812 9.54 ASIC1 ASIC2 ASIC3
6 collagen catabolic process GO:0030574 9.52 COL1A1 MMP3
7 cation transmembrane transport GO:0098655 9.51 ASIC2 ASIC3
8 skin development GO:0043588 9.48 COL1A1 CTNNB1
9 negative regulation of chondrocyte differentiation GO:0032331 9.46 CTNNB1 GDF5
10 positive regulation of epithelial to mesenchymal transition GO:0010718 9.43 COL1A1 CTNNB1 IL1B
11 response to acidic pH GO:0010447 9.33 ASIC1 ASIC2 ASIC3
12 detection of mechanical stimulus involved in sensory perception GO:0050974 9.32 ASIC2 ASIC3
13 response to mechanical stimulus GO:0009612 9.26 ASIC2 ASIC3 COL1A1 GDF5
14 sensory perception of sour taste GO:0050915 8.8 ASIC1 ASIC2 ASIC3

Molecular functions related to Frozen Shoulder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cation channel activity GO:0005261 9.5 ASIC1 ASIC2 ASIC3
2 sodium channel activity GO:0005272 9.33 ASIC1 ASIC2 ASIC3
3 ion gated channel activity GO:0022839 9.26 ASIC1 ASIC2
4 ligand-gated sodium channel activity GO:0015280 9.13 ASIC1 ASIC2 ASIC3
5 acid-sensing ion channel activity GO:0044736 8.8 ASIC1 ASIC2 ASIC3

Sources for Frozen Shoulder

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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