Aliases & Classifications for Frozen Shoulder

MalaCards integrated aliases for Frozen Shoulder:

Name: Frozen Shoulder 12 15 62 17 70
Adhesive Capsulitis of Shoulder 12 32
Bursitis 44 70
Adhesions-Capsulitis,shoulder 12

Classifications:



External Ids:

Disease Ontology 12 DOID:14188
ICD9CM 34 726.0
MeSH 44 D002062
SNOMED-CT 67 156664007
ICD10 32 M75.0
UMLS 70 C0006444 C0311223

Summaries for Frozen Shoulder

PubMed Health : 62 About frozen shoulder: If you have what is known as frozen shoulder, your shoulder gradually becomes painful and stiff without there being any clear cause. It most commonly affects people around the age of 50. Frozen shoulder will usually get better without treatment. It can take several months for the pain to disappear completely, though, and a lot longer until you can move your shoulder normally again. But a number of treatments can help to temporarily relieve the symptoms.

MalaCards based summary : Frozen Shoulder, also known as adhesive capsulitis of shoulder, is related to tenosynovitis and tendinitis, and has symptoms including pain, restricted range of motion and back pain. An important gene associated with Frozen Shoulder is ASIC3 (Acid Sensing Ion Channel Subunit 3), and among its related pathways/superpathways are ERK Signaling and Integrin Pathway. The drugs Ethyl chloride and Prilocaine have been mentioned in the context of this disorder. Affiliated tissues include scapulohumeral joint, skin and spinal cord, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Disease Ontology : 12 A connective tissue disease characterized by restriction of both active and passive range of motion located in the scapulohumeral joint and has symptom pain and has symptom restricted range of motion.

Wikipedia : 73 Adhesive capsulitis, also known as frozen shoulder, is a condition associated with shoulder pain and... more...

Related Diseases for Frozen Shoulder

Diseases related to Frozen Shoulder via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 325)
# Related Disease Score Top Affiliating Genes
1 tenosynovitis 31.0 MMP3 IL1B
2 tendinitis 30.8 MMP3 IL1B
3 bursitis 30.3 MMP3 LAPTM4A IL1B
4 epicondylitis 30.0 LAPTM4A COL1A1
5 myofascial pain syndrome 30.0 LAPTM4A ASIC3
6 arthropathy 29.9 MMP3 MMP2 IL1B
7 carpal tunnel syndrome 29.9 TGFB1 IL1B COL1A1
8 spinal stenosis 29.8 MMP3 MMP2 COL1A1
9 hyperostosis 29.8 TGFB1 MMP2 COL1A1
10 osteoarthritis 29.7 TGFB1 MMP3 IL1B GDF5
11 spondylosis 29.6 LAPTM4A IL1B
12 neuritis 29.6 TGFB1 MMP2 IL1B
13 chronic kidney disease 29.6 TGFB1 MMP3 MMP2 IL1B
14 decubitus ulcer 29.5 IL1B ASIC3
15 spondyloarthropathy 29.5 MMP3 IL1B CTNNB1
16 basal cell carcinoma 29.1 MMP3 MMP2 IL1B CTNNB1
17 liver cirrhosis 28.8 TGFB1 MMP2 IL1B CTNNB1 COL1A1
18 type 2 diabetes mellitus 28.7 TGFB1 MMP3 MMP2 IL1B IGF2 CTNNB1
19 connective tissue disease 28.7 TGFBR1 MMP3 IL1B COL1A1
20 olecranon bursitis 11.6
21 achilles bursitis 11.4
22 dupuytren contracture 11.3
23 gonococcal bursitis 11.2
24 calcific tendinitis 11.2
25 tibial collateral ligament bursitis 11.1
26 fibular collateral ligament bursitis 11.1
27 bunion 10.9
28 specific bursitis often of occupational origin 10.9
29 pes anserinus tendinitis or bursitis 10.9
30 overuse syndrome 10.9
31 repetitive motion disorders 10.9
32 repetitive stress injuries 10.9
33 periarthritis 10.4
34 gout 10.3
35 plica syndrome 10.3
36 synovitis 10.3
37 tendinopathy 10.3
38 spastic entropion 10.3 MMP3 MMP2
39 rheumatoid arthritis 10.3
40 temporal arteritis 10.3
41 osteomyelitis 10.3
42 osteochondroma 10.3
43 shoulder impingement syndrome 10.3
44 fibromatosis, gingival, 1 10.2 TGFB1 MMP2
45 synovial chondromatosis 10.2
46 anthracosis 10.2 TGFB1 IL1B
47 hypertrophic scars 10.2 TGFB1 MMP2
48 brucellosis 10.2
49 exostosis 10.2
50 cellulitis 10.2

Comorbidity relations with Frozen Shoulder via Phenotypic Disease Network (PDN):


Acute Cystitis Hypertension, Essential

Graphical network of the top 20 diseases related to Frozen Shoulder:



Diseases related to Frozen Shoulder

Symptoms & Phenotypes for Frozen Shoulder

Symptoms:

12
  • pain
  • restricted range of motion

UMLS symptoms related to Frozen Shoulder:


back pain; arthralgia; myalgia; sciatica; muscle cramp; metatarsalgia; bursal pain; bursal tenderness

GenomeRNAi Phenotypes related to Frozen Shoulder according to GeneCards Suite gene sharing:

26 (show all 25)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.78 CTNNB1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-113 9.78 CTNNB1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.78 IL1B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-120 9.78 LAPTM4A
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-132 9.78 IGF2
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-139 9.78 IL1B
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.78 LAPTM4A
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-149 9.78 LAPTM4A
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-161 9.78 LAPTM4A
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-168 9.78 IGF2 IL1B
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.78 CTNNB1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-18 9.78 CTNNB1
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-191 9.78 CTNNB1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-197 9.78 CTNNB1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-198 9.78 IL1B
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.78 LAPTM4A
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-49 9.78 CTNNB1
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-50 9.78 LAPTM4A
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-66 9.78 IGF2
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-67 9.78 CTNNB1 IGF2
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 9.78 CTNNB1
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-74 9.78 CTNNB1 IGF2
23 Decreased shRNA abundance (Z-score < -2) GR00366-A-79 9.78 CTNNB1 IGF2
24 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.78 LAPTM4A
25 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.78 IGF2

MGI Mouse Phenotypes related to Frozen Shoulder:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.18 ASIC1 ASIC2 COL1A1 CTNNB1 IGF2 IL1B
2 homeostasis/metabolism MP:0005376 10.13 ASIC3 COL1A1 CTNNB1 IGF2 IL1B LAPTM4A
3 nervous system MP:0003631 10.03 ASIC1 ASIC2 ASIC3 COL1A1 CTNNB1 IGF2
4 integument MP:0010771 9.95 ASIC3 COL1A1 CTNNB1 IGF2 IL1B TGFB1
5 craniofacial MP:0005382 9.93 COL1A1 CTNNB1 IGF2 IL1B MMP2 TGFB1
6 muscle MP:0005369 9.91 ASIC2 COL1A1 CTNNB1 IGF2 MMP2 TGFB1
7 neoplasm MP:0002006 9.8 COL1A1 CTNNB1 IL1B MMP2 TGFB1 TGFBR1
8 skeleton MP:0005390 9.65 COL1A1 CTNNB1 GDF5 IGF2 IL1B LAPTM4A
9 respiratory system MP:0005388 9.63 COL1A1 CTNNB1 IGF2 MMP2 TGFB1 TGFBR1
10 vision/eye MP:0005391 9.23 ASIC2 ASIC3 COL1A1 CTNNB1 IGF2 LAPTM4A

Drugs & Therapeutics for Frozen Shoulder

PubMed Health treatment related to Frozen Shoulder: 62

The healing process takes time and cannot be sped up. But there are various pain relief options and ways to improve shoulder mobility. During the first phase of frozen shoulder , the focus is on pain relief. Afterwards, the main goal of treatment is to help you move your shoulder more. Common treatments for pain relief include the following: Application of heat or cold to the joint Anti-inflammatory painkillers like ibuprofen (tablets or cream) Steroids (tablets or injection in shoulder ) Hydrodilatation / Arthrographic distension (injection of a solution to improve joint flexibility) Stretching exercises and physiotherapy can be used to improve joint mobility. Surgery is rarely used in the treatment of frozen shoulder because it gets better on its own, and the procedure carries the usual risks associated with surgery and the use of anesthetics. This also applies to mobilization of the joint under general anesthetic.

Drugs for Frozen Shoulder (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 79)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ethyl chloride Approved, Experimental, Investigational Phase 4 75-00-3
2
Prilocaine Approved Phase 4 721-50-6 4906
3
Ropivacaine Approved Phase 4 84057-95-4 71273 175805
4
Nitrous oxide Approved, Vet_approved Phase 4 10024-97-2 948
5
Prednisone Approved, Vet_approved Phase 4 53-03-2 5865
6
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
7
Clonidine Approved Phase 4 4205-90-7 2803
8 Lidocaine, Prilocaine Drug Combination Phase 4
9 Anesthetics, General Phase 4
10 Anesthetics, Inhalation Phase 4
11 Antiparasitic Agents Phase 4
12 Antimalarials Phase 4
13 Antiprotozoal Agents Phase 4
14 Anti-Bacterial Agents Phase 4
15 Anti-Infective Agents Phase 4
16 Pharmaceutical Solutions Phase 4
17 Neurotransmitter Agents Phase 4
18 Adrenergic Agents Phase 4
19 Adrenergic alpha-Agonists Phase 4
20 Antihypertensive Agents Phase 4
21 Sympatholytics Phase 4
22 Adrenergic Agonists Phase 4
23 Analgesics Phase 4
24
Diclofenac Approved, Vet_approved Phase 2, Phase 3 15307-86-5 3033
25
Etodolac Approved, Investigational, Vet_approved Phase 3 41340-25-4 3308
26
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
27
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
28
Betamethasone Approved, Vet_approved Phase 3 378-44-9 9782
29
Ketoprofen Approved, Vet_approved Phase 3 22071-15-4 3825
30
Etoricoxib Approved, Investigational Phase 3 202409-33-4 123619
31
Cortisone Experimental Phase 3 53-06-5 222786
32
protease inhibitors Phase 3
33 BB 1101 Phase 3
34 HIV Protease Inhibitors Phase 3
35 Analgesics, Non-Narcotic Phase 3
36 Cyclooxygenase Inhibitors Phase 3
37 Antirheumatic Agents Phase 3
38 Anti-Inflammatory Agents, Non-Steroidal Phase 3
39 Cyclooxygenase 2 Inhibitors Phase 3
40
Amitriptyline Approved Phase 2 50-48-6 2160
41
Perphenazine Approved Phase 2 58-39-9 4748
42
Nimesulide Approved, Investigational, Withdrawn Phase 2 51803-78-2 4495
43
Triamcinolone Approved, Vet_approved Phase 2 124-94-7 31307
44 Psychotropic Drugs Phase 2
45 Antidepressive Agents Phase 2
46 Amitriptyline, perphenazine drug combination Phase 2
47 Antidepressive Agents, Tricyclic Phase 2
48 Antipsychotic Agents Phase 2
49 Triamcinolone diacetate Phase 2
50 Triamcinolone hexacetonide Phase 2

Interventional clinical trials:

(show top 50) (show all 159)
# Name Status NCT ID Phase Drugs
1 Comparison of the Effects of Vapocoolant Spray and Topical Anesthetic Cream on Pain During Intra-articular Injection of Shoulder Unknown status NCT03484832 Phase 4 EMLA Cream
2 Comparative Study of the Effectiveness of an Equimolar Oxygen-nitrous Oxide Mixture During Physical Therapy for Adhesive Shoulder Capsulitis Completed NCT01087229 Phase 4 equimolar oxygen-nitrous oxide mixture;Placebo
3 Arthroscopy and Manipulation vs a Home Therapy Program in the Treatment of Adhesive Capsulitis of the Shoulder - A Prospective Randomized Study Completed NCT00160784 Phase 4
4 Chronic Insertional Achilles Tendonitis Treated With or Without Flexor Hallucis Longus Tendon Transfer: A Prospective, Randomized, Controlled Trial Completed NCT00950053 Phase 4
5 The Effect of 3 Ropivacaine Suprascapular Nerve Blocks in Subacute Adhesive Capsulitis: a Randomized Controlled Trial Completed NCT02944526 Phase 4 Ropivacaine Monohydrochloride;Placebo - Concentrate
6 Treatment of Adhesive Capsulitis: A Randomized Placebo-Controlled Trial Comparing Arthrographic Joint Distention With Steroid and Local Anesthetic Versus Arthrographic Joint Distention With Local Anesthetic Alone Completed NCT02001740 Phase 4 Triamcinalone (steroid) and lidocaine
7 Adhesive Capsulitis: Prospective Analysis of Efficacy and Financial Impact for Use of Physical Therapy in Treatment Recruiting NCT02283996 Phase 4 Depot Methylprednisolone
8 Intra-articular Doxycycline: A Novel Treatment of Adhesive Capsulitis Recruiting NCT03479502 Phase 4 Methylprednisolone Injectable Product;Doxycycline Injection
9 Clonidine for Tourniquet-related Pain in Children: A Pilot Study Not yet recruiting NCT04564430 Phase 4 Catapresan
10 Shoulder Adhesive Capsulitis and Ambulatory Continuous Interscalene Nerve Blocks: A Randomized, Triple-Masked, Placebo-Controlled Study Terminated NCT00875862 Phase 4
11 Steroid Injection for the Treatment of Greater Trochanteric Pain Syndrome: A Randomized Controlled Trial Withdrawn NCT00863889 Phase 4 Depomedrol injection;Lidocaine, Marcaine
12 Outcome in Shoulder Capsulitis (Frozen Shoulder) Between Corticosteroid and Corticosteroid With Distension Compared to Wait and See Policy, a Randomised Controlled Trial Unknown status NCT01570985 Phase 3 Triamcinolone Acetonide;Triamcinolone Acetonide
13 Sodium Hyaluronate Injection and Corticosteroids in Trochanteric Bursitis: a Randomized Controlled Study. Unknown status NCT02039804 Phase 3 Corticosteroids
14 Additive Effects of Hyaluronidase in Intra-articular Steroid Injection Treating the Initial Stage of Adhesive Capsulitis for Shoulder Completed NCT04347733 Phase 3 Triamcinolone Acetonide 40mg/mL;Hyaluronidase Injection
15 A Randomized, Multi-Center, Double-Blind, Placebo-Controlled Phase III Trial to Evaluate the Efficacy, Tolerability and Safety of MRX-7EAT Topical Patch in the Treatment of Pain Due to Recent Onset Supraspinatous and/or Subacromial Tendonitis/Bursitis and/or Subdeltoid Bursitis of Shoulder Completed NCT01506154 Phase 3 MRX-7EAT
16 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Phase III Study of the Efficacy, Tolerability and Safety of Ketoprofen Topical Patch, 20% (KTP) in the Treatment of Pain Associated With Tendonitis or Bursitis of the Shoulder, Elbow or Knee Completed NCT00352625 Phase 3 Ketoprofen Topical Patch 20%
17 A Randomized, Multi-Center, Double-Blind, Placebo-Controlled Phase III Trial to Evaluate the Efficacy, Tolerability and Safety of MRX-7EAT Etodolac-Lidocaine Topical Patch in the Treatment of Tendonitis and Bursitis of the Shoulder Completed NCT01161615 Phase 3 MRX-7EAT;Placebo
18 Treatment of Rotator Cuff Syndrome and Bursitis: A Double Blind, Controlled Trial to Assess the Efficacy and Safety of Traumeel® S Injection Versus Corticosteroid Injections and Versus Placebo Completed NCT01702233 Phase 3 Traumeel S inj;Fortecortin/Dexamethasone 8 mg/2 ml inj;Saline inj
19 A Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy and Safety of a Diclofenac Sodium Patch for the Topical Treatment of Pain Due to Mild to Moderate Tendonitis or Bursitis Completed NCT00640939 Phase 2, Phase 3 diclofenac sodium;Matching Placebo
20 Evaluation of the Effectiveness of ARTHRO -Distension Plus Intensive Mobilisation in Shoulder Capsulitis Completed NCT00724113 Phase 3
21 A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Phase III Study of the Efficacy, Tolerability and Safety of Ketoprofen Topical Patch, 20% (KTP) in the Treatment of Pain Associated With Tendonitis or Bursitis of the Shoulder, Elbow or Knee Terminated NCT00426985 Phase 3 Ketoprofen Topical Patch 20%
22 A Randomised Double Blind Controlled Trial of Injection of Local Anaesthetic and Corticosteroid Under Ultrasound Control in the Greater Trochanteric Pain Syndrome. Terminated NCT01807962 Phase 3 rapidocain and bethametsaone;sterile saline
23 Efficacy and Safety of Etoricoxib in Acute Soft Tissue Rheumatism Affecting the Shoulder Terminated NCT00876317 Phase 3 Etoricoxib 60 mg;Etoricoxib 90 mg
24 Embolization for the Treatment of Pain Secondary to Adhesive Capsulitis Unknown status NCT03676829 Phase 1, Phase 2
25 Scientifically Merged Acupuncture and Robot-assisted Technology (SMART) for Rehabilitation of Frozen Shoulder Syndrome: Second-year Project-Comparison of Robot and Conventional Physiotherapy (Including Preliminary Test on Healthy Volunteers) Unknown status NCT02206542 Phase 2
26 Autologous Stem Cells in Achilles Tendinopathy Unknown status NCT02064062 Phase 2
27 Randomized Controlled Double Blind Study of Bee Venom Therapy on Adhesive Capsulitis of the Shoulder Completed NCT01526031 Phase 2
28 Determining Shoulder Kinematics in the Prediction of Progress of Frozen Shoulder Syndrome: a Prediction Method, Validation of the Method, and Clinical Application Completed NCT01157221 Phase 1, Phase 2
29 An Open-Label, Phase II, Pilot Study on the Onset of Action of KTP, 20% in the Treatment of Acute Pain Associated With Tendonitis or Bursitis of the Shoulder, Elbow or Knee Completed NCT00903994 Phase 2 Ketoprofen Topical Patch 20%
30 Phase 2 Double-blinded, Placebo-controlled, Clinical Trial for Safety and Efficacy of Methylprednisolone Infiltration in Anserine Bursitis Treatment Completed NCT01205477 Phase 2 EXPERIMENTAL;PLACEBO
31 A Phase 2a, Open-label, Dose-ranging Study of the Safety and Effectiveness of AA4500 for the Treatment of Adhesive Capsulitis of the Shoulder Completed NCT01483963 Phase 2
32 Comparative Study Between Amitriptyline Regarding Nimesulide Associated to Nervous Blockade in the Acute Treatment of Idiopathic Adhesive Capsulitis Completed NCT01306708 Phase 2 amitriptyline
33 A Randomized, Double-blind, Placebo-controlled Study of the Safety and Efficacy of AA4500 for the Treatment of Adhesive Capsulitis of the Shoulder Completed NCT02006719 Phase 2
34 Study to Assess the Safety and Efficacy of FX006 Administered to Patients With Greater Trochanteric Bursitis Recruiting NCT04182672 Phase 2 Zilretta
35 A Phase 2, Randomized, Double Blind, Placebo Controlled Study of the Safety and Efficacy of EN3835 for the Treatment of Adhesive Capsulitis of the Shoulder Recruiting NCT04496167 Phase 2 EN3835
36 A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of FX006 in Patients With Glenohumeral Osteoarthritis or Shoulder Adhesive Capsulitis (RANGE) Terminated NCT04160091 Phase 2 FX006;Normal Saline
37 Collagenase in the Treatment of Adhesive Capsulitis (Frozen Shoulder) Withdrawn NCT00261196 Phase 2 Collagenase
38 Quantum Spectrum Radiation Emitter for Adhesive Capsulitis (Frozen Shoulder or Stiff Painful Shoulder): a Prospective, Self-controlled Trial Unknown status NCT02133833 Phase 1
39 A Stratified Investigation of a Single Injection of ZILRETTA™ (Triamcinolone Acetonide Extended-release Injectable Suspension) for Symptomatic Relief in Patients With Idiopathic Adhesive Capsulitis of the Shoulder Recruiting NCT04831255 Phase 1 triamcinolone acetonide extended-release injectable suspension
40 A Central Nervous System Focused Treatment Approach for People With Frozen Shoulder: Protocol for a Randomised Clinical Trial Unknown status NCT03320200
41 Randomized Controlled Trial, Manual Treatment and Classical Physiotherapy for One Group, PNF and Classical Physiotherapy for Other Group Unknown status NCT03705975
42 The Study of Different Treatment Programs for Patients With Frozen Shoulder Unknown status NCT01249040
43 Mobilization Techniques in Patients With Frozen Shoulder: a Randomized Multiple-Treatment Trial Unknown status NCT00172601
44 Effect of Pulsed Radiofrequency to the Suprascapular Nerve in Treating Frozen Shoulder Pain Unknown status NCT03456531 NSAIDs "ibubrofen,Aspirin"
45 Indwelling Interscalene Nerve Catheters in Surgical Management of Idiopathic Adhesive Capsulitis Unknown status NCT01606332
46 Comparing the Efficacy of Rotator Interval Steroid Injection Versus Steroid Intraarticular Hydrodilatation in the Treatment of Frozen Shoulder Unknown status NCT03678038 triamcinolone, shincort;triamcinolone, shincort
47 Scientifically Merged Acupuncture and Robot-assisted Technology (SMART) for Rehabilitation of Frozen Shoulder Syndrome: First Year Project- Verification of Acupuncture and Evaluation by Magnetic Resonance Imaging Examination Unknown status NCT02076308
48 Arthroscopic Capsulotomy vs Arthrographic Distention With Steroid in the Treatment of Primary Frozen Shoulder. A Randomized Study Unknown status NCT01029600
49 Musculoskeletal Ultrasound of the Ankles in Erysipelas-like Erythema of Familial Mediterranean Fever Unknown status NCT03917277
50 Hydrothermal Ablation in Recurrent and Chronic Symptomatic Bursitis With the Ablaflex Device: An Open, Exploratory, 6-month Dose-tolerance and Dose Response Study Unknown status NCT02841462

Search NIH Clinical Center for Frozen Shoulder

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Ibuprofen
Indomethacin
INDOMETHACIN PWDR
INDOMETHACIN SODIUM
Naproxen
Naproxen sodium
solufenum

Cochrane evidence based reviews: bursitis

Genetic Tests for Frozen Shoulder

Anatomical Context for Frozen Shoulder

The Foundational Model of Anatomy Ontology organs/tissues related to Frozen Shoulder:

19
Scapulohumeral Joint

MalaCards organs/tissues related to Frozen Shoulder:

40
Skin, Spinal Cord, Breast, Endothelial, Bone, Bone Marrow, Eye

Publications for Frozen Shoulder

Articles related to Frozen Shoulder:

(show top 50) (show all 3819)
# Title Authors PMID Year
1
Reply to the Park and Lee regarding: "Effects of joint capsular release on range of motion in patients with frozen shoulder". 61
33440239 2021
2
Outcome of manipulation under anesthesia with or without intra-articular steroid injection for treating frozen shoulder: A retrospective cohort study. 61
33787567 2021
3
What is the optimum rehabilitation for patients who have undergone release procedures for frozen shoulder? A UK survey. 61
33588155 2021
4
Letter to the Editor regarding Hagiwara et al: "Effects of joint capsular release on range of motion in patients with frozen shoulder". 61
33440240 2021
5
Pathological changes of frozen shoulder in rat model and the therapeutic effect of PPAR-γ agonist. 61
33222263 2021
6
Hip Abductor and Peritrochanteric Space Conditions. 61
33673889 2021
7
The impact of gender on the clinical presentation, management, and surgical outcomes of patients with native-joint septic arthritis. 61
32613746 2021
8
Does the timing of surgical intervention impact the clinical outcomes and overall duration of symptoms in frozen shoulder? 61
32750533 2021
9
A Rat Model of Frozen Shoulder Demonstrating the Effect of Transcatheter Arterial Embolization on Angiography, Histopathology, and Physical Activity. 61
33309281 2021
10
Management of septic and aseptic prepatellar bursitis: a systematic review. 61
33721054 2021
11
Surface Shape of the Calcaneal Tuberosity and the Occurrence of Retrocalcaneal Bursitis among Runners. 61
33799691 2021
12
A case of ankle osteoarthritis associated with lateral premalleolar bursitis caused by chronic ankle instability. 61
33676290 2021
13
Arthroscopic bursectomy less effective in the degenerative shoulder with chronic subacromial pain. 61
33681841 2021
14
Saline Load Test and Quilting Sutures to Treat Intractable Lateral Malleolar Bursitis. 61
33431314 2021
15
[Bacterial acute non necrosing cellulitis (erysipelas) in adult]. 61
33176944 2021
16
Magnetic resonance imaging of deltoid muscle/tendon tears: a descriptive study. 61
33661326 2021
17
Public interest in musculoskeletal symptoms and disorders during the COVID-19 pandemic : Infodemiology study. 61
33779835 2021
18
Surgical treatment for insertional Achilles tendinopathy and retrocalcaneal bursitis: more than 1 year of follow-up. 61
33682490 2021
19
A Case Report of Bursitis, Bacteremia, and Disseminated Infection of Mycobacteroides (Mycobacterium) abscessus subsp. massiliense. 61
33775997 2021
20
Diagnostic Labels for Rotator Cuff Disease Can Increase People's Perceived Need for Shoulder Surgery: An Online Randomized Controlled Experiment. 61
33789444 2021
21
Giant iliopsoas bursitis in systemic juvenile idiopathic arthritis. 61
33586300 2021
22
Physical Therapy Management of Nontraumatic Shoulder Problems Lacks High-Quality Clinical Practice Guidelines: A Systematic Review With Quality Assessment Using the AGREE II Checklist. 61
33356772 2021
23
Iliopsoas Bursitis Related to Calcium Pyrophosphate Deposition Disease. 61
33583905 2021
24
Septic Malleolar Bursitis in a Patient with an Ankle Electronic Monitoring Device: A Case Report. 61
33560963 2021
25
Effects of Hyperosmolar Dextrose Injection in Patients With Rotator Cuff Disease and Bursitis: A Randomized Controlled Trial. 61
32926850 2021
26
Arthroscopic capsular release to treat idiopathic frozen shoulder: How much release is needed? 61
33333264 2021
27
A prospective double-blind randomized trial on ultrasound-guided versus blind intra-articular corticosteroid injections for primary frozen shoulder. 61
33517741 2021
28
A Multisite Injection Is More Effective Than a Single Glenohumeral Injection of Corticosteroid in the Treatment of Primary Frozen Shoulder: A Randomized Controlled Trial. 61
33581295 2021
29
Endoscopic speed bridge: A new treatment for insertional Achilles tendinopathy. 61
33578040 2021
30
Acute-Onset Achilles Tendon Pain and Swelling Treated with an Amniotic Fluid-Derived Allograft: A Case Study. 61
33690801 2021
31
Progressive Monoarticular Inflammatory Arthritis Following Influenza Vaccination. 61
33718794 2021
32
Atypical presentation of shoulder brucellosis misdiagnosed as subacromial bursitis: A case report. 61
33585641 2021
33
Machine learning algorithms trained with pre-hospital acquired history-taking data can accurately differentiate diagnoses in patients with hip complaints. 61
33573429 2021
34
Arthroscopic Surgical Management of Shoulder Secondary to Shoulder injury related to vaccine administration (SIRVA): A Case Report. 61
33610727 2021
35
Cerclage wire fixation of trochanteric osteotomies in complex hip revision: our experience and comparison with cable-plate fixation. 61
33601917 2021
36
Hydrodilatation with corticosteroids is the most effective conservative management for frozen shoulder. 61
33420809 2021
37
Frozen Shoulder: A Systematic Review of Cellular, Molecular, and Metabolic Findings. 61
33512972 2021
38
What is the optimal surgical intervention for patients with frozen shoulder and a concomitant partial-thickness rotator cuff tear? 61
33554172 2021
39
Frozen shoulder. 61
33516336 2021
40
Elasticity of the coracohumeral ligament in patients with frozen shoulder following rotator interval injection: a case series. 61
33500798 2021
41
Frozen shoulder - Authors' reply. 61
33516337 2021
42
The role of 18F-FDG PET/CT in the diagnosis of frozen shoulder. 61
32170356 2021
43
[Double internal fixations of clavicle and scapula and intraoperative reduction of glenopolar angle for treatment of floating shoulder injuries]. 61
33448203 2021
44
Tender point examination with palpation in different shoulder pathologies: A retrospective study. 61
33431256 2021
45
The efficacy of physiotherapy interventions in the treatment of adhesive capsulitis: A systematic review. 61
33185587 2021
46
Capsular distention for adhesive capsulitis in a pediatric patient with acute flaccid myelitis: A case report. 61
32716334 2021
47
Bilateral subacromial-subdeltoid bursitis in elderly patients: a diagnostic challenge. 61
33253108 2021
48
Resistance band training after triamcinolone acetonide injection for subacromial bursitis: A randomized clinical trial. 61
33043381 2021
49
Hydraulic distension as a treatment for patellofemoral pain syndrome (PFPS) non-responsive to standard rehabilitation. 61
33279390 2021
50
Reply to the comment on: Bilateral subacromial-subdeltoid bursitis in elderly patients: a diagnostic challenge by Slouma et al. 61
33253090 2021

Variations for Frozen Shoulder

Expression for Frozen Shoulder

Search GEO for disease gene expression data for Frozen Shoulder.

Pathways for Frozen Shoulder

Pathways related to Frozen Shoulder according to GeneCards Suite gene sharing:

(show all 45)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.69 TGFBR1 TGFB1 IL1B IGF2 GDF5 CTNNB1
2
Show member pathways
13.28 TGFBR1 TGFB1 MMP3 MMP2 CTNNB1 COL1A1
3
Show member pathways
13.15 TGFBR1 TGFB1 IL1B IGF2 GDF5 CTNNB1
4
Show member pathways
13.08 TGFBR1 TGFB1 MMP3 IL1B CTNNB1
5
Show member pathways
12.93 TGFBR1 TGFB1 IGF2 GDF5 COL1A1
6 12.7 TGFBR1 TGFB1 MMP2 IGF2 CTNNB1
7 12.65 TGFBR1 TGFB1 IL1B IGF2
8
Show member pathways
12.65 TGFBR1 TGFB1 IGF2 CTNNB1
9
Show member pathways
12.59 TGFB1 IL1B IGF2 GDF5
10
Show member pathways
12.59 TGFB1 MMP3 MMP2 GDF5 COL1A1
11
Show member pathways
12.55 TGFBR1 TGFB1 MMP2 COL1A1
12
Show member pathways
12.29 TGFB1 IGF2 GDF5 CTNNB1
13
Show member pathways
12.18 TGFBR1 TGFB1 MMP2 CTNNB1
14
Show member pathways
12.06 TGFBR1 TGFB1 CTNNB1
15
Show member pathways
12.06 TGFBR1 TGFB1 IL1B IGF2 GDF5
16 12.01 TGFBR1 TGFB1 MMP2 CTNNB1
17 11.99 MMP2 IL1B CTNNB1
18 11.97 TGFBR1 TGFB1 GDF5 CTNNB1
19 11.97 TGFB1 MMP2 IGF2 CTNNB1 COL1A1
20 11.93 TGFBR1 TGFB1 IL1B
21 11.84 TGFB1 IL1B COL1A1
22 11.81 TGFB1 IL1B COL1A1
23 11.79 MMP3 MMP2 CTNNB1 COL1A1
24 11.77 TGFBR1 TGFB1 GDF5
25 11.76 TGFB1 MMP3 IL1B
26
Show member pathways
11.75 TGFBR1 TGFB1 IL1B
27
Show member pathways
11.75 MMP2 IL1B CTNNB1 COL1A1 ASIC3 ASIC2
28 11.73 TGFB1 MMP3 MMP2 IL1B
29
Show member pathways
11.57 MMP3 MMP2 IL1B
30 11.57 TGFBR1 TGFB1 MMP3 MMP2
31 11.56 TGFB1 MMP2 IL1B
32 11.54 TGFBR1 TGFB1 MMP2 CTNNB1
33
Show member pathways
11.51 TGFBR1 TGFB1 MMP2
34 11.51 TGFBR1 TGFB1 CTNNB1
35 11.43 TGFBR1 TGFB1 CTNNB1
36 11.35 TGFBR1 IL1B COL1A1
37 11.35 TGFBR1 TGFB1 MMP2 IL1B COL1A1
38 11.24 MMP3 MMP2 IGF2 COL1A1
39 11.11 TGFBR1 TGFB1
40
Show member pathways
11.11 MMP3 IGF2
41 11.09 TGFBR1 TGFB1 CTNNB1
42 10.99 MMP2 IGF2
43 10.9 TGFB1 IL1B IGF2 GDF5 COL1A1
44 10.89 TGFBR1 TGFB1
45 10.71 TGFB1 IL1B

GO Terms for Frozen Shoulder

Cellular components related to Frozen Shoulder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 TGFB1 MMP3 MMP2 IL1B IGF2 GDF5
2 extracellular space GO:0005615 9.5 TGFB1 MMP3 MMP2 IL1B IGF2 GDF5
3 extracellular matrix GO:0031012 8.92 TGFB1 MMP3 MMP2 COL1A1

Biological processes related to Frozen Shoulder according to GeneCards Suite gene sharing:

(show all 39)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 10.04 TGFBR1 TGFB1 IL1B CTNNB1 COL1A1
2 positive regulation of cell proliferation GO:0008284 9.97 TGFBR1 TGFB1 IL1B IGF2 CTNNB1
3 cytokine-mediated signaling pathway GO:0019221 9.92 TGFB1 MMP3 MMP2 IL1B
4 positive regulation of cell migration GO:0030335 9.9 TGFBR1 TGFB1 IL1B COL1A1
5 sodium ion transport GO:0006814 9.85 ASIC3 ASIC2 ASIC1
6 response to estradiol GO:0032355 9.83 TGFB1 CTNNB1 COL1A1
7 transforming growth factor beta receptor signaling pathway GO:0007179 9.83 TGFBR1 TGFB1 GDF5
8 wound healing GO:0042060 9.82 TGFBR1 TGFB1 COL1A1
9 sodium ion transmembrane transport GO:0035725 9.82 ASIC3 ASIC2 ASIC1
10 cellular response to mechanical stimulus GO:0071260 9.79 TGFB1 IL1B COL1A1
11 cation transport GO:0006812 9.78 ASIC3 ASIC2 ASIC1
12 cellular response to growth factor stimulus GO:0071363 9.74 TGFBR1 TGFB1 CTNNB1
13 cellular response to transforming growth factor beta stimulus GO:0071560 9.71 TGFBR1 TGFB1 COL1A1
14 skeletal system development GO:0001501 9.71 TGFBR1 IGF2 CTNNB1 COL1A1
15 negative regulation of neurogenesis GO:0050768 9.68 IL1B CTNNB1
16 positive regulation of histone acetylation GO:0035066 9.68 TGFB1 IL1B
17 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007178 9.67 TGFBR1 GDF5
18 positive regulation of SMAD protein signal transduction GO:0060391 9.67 TGFBR1 TGFB1
19 positive regulation of cell division GO:0051781 9.67 TGFB1 IL1B IGF2
20 response to amyloid-beta GO:1904645 9.66 MMP3 MMP2
21 pathway-restricted SMAD protein phosphorylation GO:0060389 9.65 TGFBR1 TGFB1
22 positive regulation of pathway-restricted SMAD protein phosphorylation GO:0010862 9.65 TGFBR1 TGFB1 GDF5
23 response to cholesterol GO:0070723 9.63 TGFBR1 TGFB1
24 cellular response to UV-A GO:0071492 9.63 MMP3 MMP2
25 epithelial to mesenchymal transition GO:0001837 9.63 TGFBR1 TGFB1 CTNNB1
26 monovalent inorganic cation transport GO:0015672 9.62 ASIC2 ASIC1
27 skeletal system morphogenesis GO:0048705 9.61 TGFBR1 MMP2 COL1A1
28 bone trabecula formation GO:0060346 9.59 MMP2 COL1A1
29 intramembranous ossification GO:0001957 9.58 MMP2 COL1A1
30 regulation of SMAD protein signal transduction GO:0060390 9.56 TGFB1 GDF5
31 germ cell migration GO:0008354 9.55 TGFBR1 TGFB1
32 face morphogenesis GO:0060325 9.54 TGFB1 MMP2 COL1A1
33 detection of mechanical stimulus involved in sensory perception GO:0050974 9.52 ASIC3 ASIC2
34 ossification involved in bone remodeling GO:0043932 9.51 TGFB1 GDF5
35 negative regulation of chondrocyte differentiation GO:0032331 9.5 TGFBR1 GDF5 CTNNB1
36 response to mechanical stimulus GO:0009612 9.46 GDF5 COL1A1 ASIC3 ASIC2
37 response to acidic pH GO:0010447 9.43 ASIC3 ASIC2 ASIC1
38 sensory perception of sour taste GO:0050915 9.13 ASIC3 ASIC2 ASIC1
39 positive regulation of epithelial to mesenchymal transition GO:0010718 9.02 TGFBR1 TGFB1 IL1B CTNNB1 COL1A1

Molecular functions related to Frozen Shoulder according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 growth factor activity GO:0008083 9.61 TGFB1 IGF2 GDF5
2 cation channel activity GO:0005261 9.5 ASIC3 ASIC2 ASIC1
3 sodium channel activity GO:0005272 9.43 ASIC3 ASIC2 ASIC1
4 I-SMAD binding GO:0070411 9.4 TGFBR1 CTNNB1
5 type II transforming growth factor beta receptor binding GO:0005114 9.37 TGFBR1 TGFB1
6 acid-sensing ion channel activity GO:0044736 9.16 ASIC3 ASIC1
7 ion gated channel activity GO:0022839 8.96 ASIC2 ASIC1
8 ligand-gated sodium channel activity GO:0015280 8.8 ASIC3 ASIC2 ASIC1

Sources for Frozen Shoulder

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....