MCID: FRT005
MIFTS: 35

Fruit Allergy

Categories: Immune diseases

Aliases & Classifications for Fruit Allergy

MalaCards integrated aliases for Fruit Allergy:

Name: Fruit Allergy 12 15
Allergy to Fruit 71

Classifications:



External Ids:

Disease Ontology 12 DOID:0060503
UMLS 71 C0685901

Summaries for Fruit Allergy

Disease Ontology : 12 A food allergy triggered by a plant fruit product.

MalaCards based summary : Fruit Allergy, also known as allergy to fruit, is related to apricot allergy and peach allergy. An important gene associated with Fruit Allergy is CCR6 (C-C Motif Chemokine Receptor 6), and among its related pathways/superpathways are Allograft rejection and Th17 cell differentiation. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include testes, skin and bone marrow, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 74 A fruit allergy is a food allergy. Fruit allergies make up about ten percent of all food related... more...

Related Diseases for Fruit Allergy

Diseases related to Fruit Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 342)
# Related Disease Score Top Affiliating Genes
1 apricot allergy 33.5 PEDS1 ENPP3
2 peach allergy 33.2 SCP2 PEDS1 PDCL PDC
3 tomato allergy 33.2 PDCL PDC
4 melon allergy 32.9 PDCL PDC ENPP3
5 orange allergy 32.9 SCP2 PDCL PDC IL5
6 apple allergy 32.6 SCP2 PEDS1 PDCL PDC GHITM
7 latex allergy 30.1 PDCL IL5 IL4 IL13 FLG
8 ige responsiveness, atopic 30.0 IL5 IL4 IL13 IL10
9 allergic rhinitis 29.6 IL5 IL4 IL13 IL10
10 food allergy 29.0 SCP2 IL5 IL4 IL13 IL10 FOXP3
11 pollen allergy 28.0 SCP2 PEDS1 PDCL PDC IL5 IL13
12 rhinitis 27.7 TSLP IL5 IL4 IL33 IL13 IL10
13 allergic hypersensitivity disease 27.1 TSLP PEDS1 IL5 IL4 IL33 IL13
14 legume allergy 25.9 TSLP TNXB SCP2 PEDS1 PDCL PDC
15 cherry allergy 12.0
16 indian plum allergy 12.0
17 plum allergy 12.0
18 cytokine deficiency 10.5 IL5 IL13
19 rocuronium allergy 10.5 PEDS1 CD63
20 aztreonam allergy 10.5 IL5 IL13
21 angioimmunoblastic lymphadenopathy with dysproteinemia 10.5 IL5 IL13
22 respiratory syncytial virus infectious disease 10.5 IL5 IL13
23 dermatitis, atopic, 3 10.4 TSLP FLG
24 cefuroxime allergy 10.4 IL5 IL13
25 crustacean allergy 10.4 PEDS1 CCR6
26 shrimp allergy 10.4 PEDS1 CCR6
27 aneruptive fever 10.4 IL13 FOXP3
28 exercise-induced anaphylaxis 10.4 FLG ENPP3
29 ceftriaxone allergy 10.4 PEDS1 IL5 IL13
30 chlorhexidine allergy 10.4 PEDS1 ENPP3
31 atopic keratoconjunctivitis 10.4 IL5 IL4
32 scleritis 10.4 IL5 IL4 CCR6
33 celery allergy 10.4 SCP2 PEDS1 GHITM
34 cough variant asthma 10.3 IL5 IL4 IL13
35 vernal keratoconjunctivitis 10.3 IL5 IL4 IL13
36 angiostrongyliasis 10.3 IL5 IL4 IL13
37 irritant dermatitis 10.3 TSLP IL4 FLG
38 carbapenem allergy 10.3 IL13 ENPP3
39 cefaclor allergy 10.3 IL5 IL13 CD63
40 erythema multiforme 10.3 IL5 IL4 IL13
41 transient arthritis 10.3 FLG CD4
42 seborrheic dermatitis 10.3 FLG CD4 CCR6
43 onchocerciasis 10.3 IL5 IL4 IL13
44 amoxicillin allergy 10.3 ENPP3 CD63
45 neurodermatitis 10.3 IL4 FLG
46 tropical endomyocardial fibrosis 10.3 IL4 IL10
47 caplan's syndrome 10.3 FOXP3 CD4
48 acute proliferative glomerulonephritis 10.3 ICOSLG CD4 CCR6
49 norwegian scabies 10.3 IL5 CD4
50 autoimmune glomerulonephritis 10.3 ICOSLG CD4 CCR6

Graphical network of the top 20 diseases related to Fruit Allergy:



Diseases related to Fruit Allergy

Symptoms & Phenotypes for Fruit Allergy

MGI Mouse Phenotypes related to Fruit Allergy:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 10.03 CCR6 CD4 ENPP3 FOXP3 IL10 IL13
2 homeostasis/metabolism MP:0005376 10.03 CCR6 CD4 CD63 FOXP3 IL10 IL13
3 digestive/alimentary MP:0005381 10.02 CD4 CD63 ENPP3 FOXP3 IL10 IL13
4 immune system MP:0005387 9.77 CCR6 CD4 ENPP3 FOXP3 IL10 IL13
5 respiratory system MP:0005388 9.23 ENPP3 FOXP3 IL10 IL13 IL33 IL4

Drugs & Therapeutics for Fruit Allergy

Drugs for Fruit Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Salmonella Typhi Vi O-Acetyl Pectin-rEPA Conjugate Vaccine, Phase 1 Trial in Adults at NIH CC Completed NCT00277147 Phase 1 BB IND 6989

Search NIH Clinical Center for Fruit Allergy

Genetic Tests for Fruit Allergy

Anatomical Context for Fruit Allergy

MalaCards organs/tissues related to Fruit Allergy:

40
Testes, Skin, Bone Marrow, Bone

Publications for Fruit Allergy

Articles related to Fruit Allergy:

(show top 50) (show all 97)
# Title Authors PMID Year
1
Characterization of a 7 kDa pollen allergen belonging to the gibberellin-regulated protein family from three Cupressaceae species. 61
32506709 2020
2
Pru p 7 Predicts Severe Reactions after Ingestion of Peach in Japanese Children and Adolescents. 61
31822011 2020
3
Novel in vitro test for pollen-related vegetable/fruit allergy using the EXiLE method. 61
31964599 2020
4
Severe anaphylaxis after pelvic examination: a case report of dual latex and chlorhexidine allergies. 61
30976286 2019
5
Peanut Allergy in Spanish Children: Comparative Profile of Peanut Allergy versus Tolerance. 61
30677773 2019
6
[Latex allergy self-report in medical students: prevalence and associated factors]. 61
29723937 2018
7
[ORAL AND SYSTEMIC SYMPTOMS IN CHILDREN WITH FRUIT ALLERGY]. 61
29553113 2018
8
High prevalence of sensitization to gibberellin-regulated protein (peamaclein) in fruit allergies with negative immunoglobulin E reactivity to Bet v 1 homologs and profilin: Clinical pattern, causative fruits and cofactor effect of gibberellin-regulated protein allergy. 61
28326616 2017
9
Occupational allergy to fruit flies (Drosophila melanogaster) in laboratory workers. 61
28039199 2017
10
High frequency of IgE sensitization towards kiwi seed storage proteins among peanut allergic individuals also reporting allergy to kiwi. 61
29118674 2017
11
Newly acquired kiwi fruit allergy after bone marrow transplantation from a kiwi-allergic donor. 61
26990607 2016
12
Papain Induced Occupational Asthma with Kiwi and Fig Allergy. 61
26739411 2016
13
An overview of fruit allergy and the causative allergens. 61
26549334 2015
14
Immunotherapy (oral and sublingual) for food allergy to fruits. 61
26558953 2015
15
The Pollen-Food Olive-Olive Syndrome. 61
26578052 2015
16
Familial kiwi fruit allergy: a case report. 61
25838097 2015
17
Identification of Sola l 4 as Bet v 1 homologous pathogenesis related-10 allergen in tomato fruits. 61
24510486 2015
18
An IgE-Mediated Allergic Reaction Caused by Mulberry Fruit. 61
25729628 2015
19
Molecular characterization of recombinant mus a 5 allergen from banana fruit. 61
24198217 2014
20
Latex glove-related symptoms among health care workers: a self-report questionnaire-based survey. 61
24819288 2014
21
Molecular characterization of contact urticaria in patients with melon allergy. 61
24640940 2014
22
Effects of long-term storage on Mal d 1 content of four apple cultivars with initial low Mal d 1 content. 61
24130074 2014
23
The prevalence of latex sensitisation and allergy and associated risk factors among healthcare workers using hypoallergenic latex gloves at King Edward VIII Hospital, KwaZulu-Natal South Africa: a cross-sectional study. 61
24327359 2013
24
[Profilins: allergens with clinical relevance]. 61
24274609 2013
25
Molecular cloning, characterization, and expression of Cuc m 2, a major allergen in Cucumis melo. 61
26989709 2013
26
New food allergies in a European non-Mediterranean region: is Cannabis sativa to blame? 61
23549061 2013
27
IgE mediated food allergy in Korean children: focused on plant food allergy. 61
23403730 2013
28
Anaphylaxis and generalized urticaria from eating Chinese bayberry fruit. 61
23024053 2012
29
Molecular and immunological characterization of Mus a 5 allergen from banana fruit. 61
22162266 2012
30
Graph based study of allergen cross-reactivity of plant lipid transfer proteins (LTPs) using microarray in a multicenter study. 61
23272072 2012
31
The involvement of thaumatin-like proteins in plant food cross-reactivity: a multicenter study using a specific protein microarray. 61
22970164 2012
32
Longitudinal study on specific IgE against natural rubber latex, banana and kiwi in patients with spina bifida. 61
21512968 2011
33
Identification of european allergy patterns to the allergen families PR-10, LTP, and profilin from Rosaceae fruits. 61
19851893 2011
34
Perioperative allergy: risk factors. 61
22014923 2011
35
Molecular diagnosis of fruit and vegetable allergy. 61
21460714 2011
36
Sensitization profiles to purified plant food allergens among pediatric patients with allergy to banana. 61
21284746 2011
37
Frozen fruit skin prick test for the diagnosis of fruit allergy. 61
21337912 2010
38
Cysteine proteinase inhibitor Act d 4 is a functional allergen contributing to the clinical symptoms of kiwifruit allergy. 61
19885843 2010
39
Food allergy due to olive. 61
20128426 2009
40
Food contact hypersensitivity syndrome: the mucosal contact urticaria paradigm. 61
18582231 2008
41
Reported food allergy to peanut, tree nuts and fruit: comparison of clinical manifestations, prescription of medication and impact on daily life. 61
18588558 2008
42
The clinical implications of latex-fruit allergy. 61
18211465 2008
43
Latex allergy in health care workers in Taiwan: prevalence, clinical features. 61
17006694 2007
44
Identification of latex UDP glucose pyrophosphorylase (Hev b UDPGP) as a novel cause of latex fruit allergy syndrome. 61
17523384 2007
45
Latex allergen sensitization and risk factors due to glove use by health care workers at public health units in Florianopolis, Brazil. 61
17323860 2007
46
Relevance of the recombinant lipid transfer protein of Hevea brasiliensis: IgE-binding reactivity in fruit-allergic adults. 61
17165273 2006
47
[Latex allergy]. 61
16583955 2006
48
Latex allergy in children: a follow-up study. 61
16540066 2006
49
[Four cases of pollen-food allergy syndrome suspected the cross reactivity including latex]. 61
16407680 2005
50
Wine anaphylaxis in a German patient: IgE-mediated allergy against a lipid transfer protein of grapes. 61
15650314 2005

Variations for Fruit Allergy

Expression for Fruit Allergy

Search GEO for disease gene expression data for Fruit Allergy.

Pathways for Fruit Allergy

Pathways related to Fruit Allergy according to GeneCards Suite gene sharing:

(show all 17)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 IL5 IL4 IL13 IL10 ICOSLG FOXP3
2
Show member pathways
12.45 IL5 IL4 IL13 IL10 FOXP3 CD4
3 12.39 IL4 IL10 FOXP3 ENPP3 CD63
4
Show member pathways
12.29 TSLP IL5 IL4 IL13 IL10
5 11.82 IL5 IL4 IL10 CD4
6 11.74 IL5 IL4 CD4
7 11.65 IL5 IL4 IL13
8
Show member pathways
11.6 IL5 IL4 FOXP3
9 11.51 IL5 IL4 IL13
10 11.5 IL5 IL4 IL10
11 11.38 IL4 IL13 IL10
12 11.16 TSLP IL5 IL4 IL33 IL13
13 11.16 IL5 IL4 IL33 IL13 IL10 FOXP3
14 11.13 TSLP IL5 IL4 IL33 IL13 IL10
15 11.04 IL5 IL4 IL13 IL10
16 11.02 IL5 IL4 IL13 IL10 CD4
17 10.66 IL5 IL4 IL13

GO Terms for Fruit Allergy

Cellular components related to Fruit Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.76 TSLP TNXB IL5 IL4 IL33 IL13
2 extracellular region GO:0005576 9.61 TSLP TNXB IL5 IL4 IL33 IL13
3 external side of plasma membrane GO:0009897 9.02 IL13 ICOSLG ENPP3 CD4 CCR6

Biological processes related to Fruit Allergy according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.8 IL5 IL4 IL13 IL10 CD4
2 immune response GO:0006955 9.8 IL5 IL4 IL13 IL10 CD4 CCR6
3 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.73 TSLP IL4 IL13
4 positive regulation of B cell proliferation GO:0030890 9.65 IL5 IL4 IL13
5 negative regulation of endothelial cell apoptotic process GO:2000352 9.63 IL4 IL13 IL10
6 macrophage activation GO:0042116 9.61 IL4 IL13
7 positive regulation of immunoglobulin secretion GO:0051024 9.6 IL5 IL33
8 positive regulation of interleukin-10 secretion GO:2001181 9.59 IL4 IL13
9 positive regulation of mast cell degranulation GO:0043306 9.58 IL4 IL13
10 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.58 IL4 IL10
11 positive regulation of MHC class II biosynthetic process GO:0045348 9.57 IL4 IL10
12 negative regulation of T-helper 17 cell differentiation GO:2000320 9.55 IL4 FOXP3
13 negative regulation of inflammatory response GO:0050728 9.55 IL4 IL13 IL10 FOXP3 ENPP3
14 positive regulation of interleukin-5 production GO:0032754 9.54 TSLP IL33
15 negative regulation of interferon-gamma production GO:0032689 9.54 IL33 IL10 FOXP3
16 type 2 immune response GO:0042092 9.52 IL4 IL10
17 regulation of isotype switching GO:0045191 9.51 IL4 IL10
18 negative regulation of chronic inflammatory response GO:0002677 9.49 IL4 FOXP3
19 negative regulation of complement-dependent cytotoxicity GO:1903660 9.43 IL4 IL13
20 positive regulation of macrophage activation GO:0043032 9.43 IL33 IL13 IL10
21 T cell activation GO:0042110 9.26 IL4 ICOSLG FOXP3 CD4
22 positive regulation of interleukin-13 production GO:0032736 8.8 TSLP IL4 IL33

Molecular functions related to Fruit Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.1 TSLP IL5 IL4 IL33 IL13 IL10

Sources for Fruit Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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