MCID: FCH001
MIFTS: 49

Fuchs' Endothelial Dystrophy

Categories: Rare diseases, Eye diseases

Aliases & Classifications for Fuchs' Endothelial Dystrophy

MalaCards integrated aliases for Fuchs' Endothelial Dystrophy:

Name: Fuchs' Endothelial Dystrophy 12 25 44 15
Fuchs Endothelial Corneal Dystrophy 53 25 59 29
Late Hereditary Endothelial Dystrophy 53 59
Endoepithelial Corneal Dystrophy 53 59
Fuchs Endothelial Dystrophy 25 73
Fuchs Corneal Dystrophy 25 37
Fuchs Dystrophy 25 55
Fecd 53 59
Corneal Dystrophy, Fuchs' Endothelial, 1 73
Dystrophy, Corneal, Fuchs Endothelial 40
Fuchs' Endothelial Corneal Dystrophy 12
Corneal Dystrophy, Fuchs Endothelial 55
Fuchs' Corneal Dystrophy 12
Fuchs Atrophy 25
Fced 12

Characteristics:

Orphanet epidemiological data:

59
fuchs endothelial corneal dystrophy
Inheritance: Autosomal dominant,Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:11555
ICD10 33 H18.51
MeSH 44 D005642
NCIt 50 C84721
Orphanet 59 ORPHA98974
UMLS via Orphanet 74 C0016781
ICD10 via Orphanet 34 H18.5
KEGG 37 H00960

Summaries for Fuchs' Endothelial Dystrophy

NIH Rare Diseases : 53 Fuchs endothelial corneal dystrophy (FECD) is an eye disease. It affects the thin layer of cells that line the back part of the cornea. This layer is called the endothelium. The disease occurs when these cells slowly start to die off. The cells help pump excess fluid out of the cornea. As more and more cells are lost, fluid begins to build up in the cornea, causing swelling and a cloudy cornea. There are several forms of the disease according to the age of onset of the symptoms and the cause. The early-onset form is very rare and is known as Fuchs endothelial corneal dystrophy 1 (or early-onset Fuchs endothelial corneal dystrophy) and it is caused by a change (mutation) in the COL8A2 gene. Late-onset Fuchs endothelial corneal dystrophies are common and include:Fuchs endothelial corneal dystrophy 2 (caused by a mutation in an unknown gene located in chromosome13) Fuchs endothelial corneal dystrophy 3 (may be caused by TCF4 gene mutations) Fuchs endothelial corneal dystrophy 4 (caused by a mutation in the SLC4A11 gene) Fuchs endothelial corneal dystrophy 5 (caused by a mutation in an unknown gene located in chromosome 15) Fuchs endothelial corneal dystrophy 6 (caused by a mutation in the ZEB1 gene) Fuchs endothelial corneal dystrophy 7 (caused by a mutation in an unknown gene located in chromosome 9) Fuchs endothelial corneal dystrophy 8 (caused by heterozygous mutation in the AGBL1 gene).  Early in the disease, patients typically do not have symptoms. In the late-onset forms, the symptoms start around 50 or 60 years and include discomfort and painful episodes of recurrent corneal wounds and hazy vision. Over time, discomfort may diminish but severe impairment of visual acuity, and even blindness and cataracts in elderly patients, may be observed. Once the vision has worsened, the recommended treatment is a penetrating graft which has excellent results in most cases.

MalaCards based summary : Fuchs' Endothelial Dystrophy, also known as fuchs endothelial corneal dystrophy, is related to corneal edema and corneal dystrophy, posterior polymorphous, 1. An important gene associated with Fuchs' Endothelial Dystrophy is COL8A2 (Collagen Type VIII Alpha 2 Chain), and among its related pathways/superpathways are DNA Damage Response (only ATM dependent) and Nanomaterial induced apoptosis. The drugs Loteprednol and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include endothelial and eye, and related phenotypes are immune system and vision/eye

Genetics Home Reference : 25 Fuchs endothelial dystrophy is a condition that causes vision problems. The first symptom of this condition is typically blurred vision in the morning that usually clears during the day. Over time, affected individuals lose the ability to see details (visual acuity). People with Fuchs endothelial dystrophy also become sensitive to bright lights.

Disease Ontology : 12 A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of Descemet's membrane, leading to corneal edema and loss of vision.

Related Diseases for Fuchs' Endothelial Dystrophy

Diseases related to Fuchs' Endothelial Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 corneal edema 31.0 COL8A2 SLC4A11 TGFBI
2 corneal dystrophy, posterior polymorphous, 1 30.8 COL8A2 SLC4A11 VSX1 ZEB1
3 corneal dystrophy 30.2 AGBL1 COL8A2 SLC4A11 TCF4 TGFBI VSX1
4 corneal dystrophy, fuchs endothelial, 3 12.0
5 corneal dystrophy, fuchs endothelial, 1 11.7
6 corneal dystrophy, fuchs endothelial, 2 11.4
7 corneal dystrophy, fuchs endothelial, 4 11.4
8 corneal dystrophy, fuchs endothelial, 6 11.4
9 corneal dystrophy, fuchs endothelial, 5 11.1
10 endotheliitis 10.8
11 corneal dystrophy, endothelial, x-linked 10.8 SLC4A11 VSX1
12 anterior segment dysgenesis 10.8 PITX2 TGFBI VSX1
13 kashin-beck disease 10.8 BAX BCL2
14 mucinous bronchioloalveolar adenocarcinoma 10.8 KRT20 MUC1
15 corneal dystrophy, thiel-behnke type 10.7 COL8A2 SLC4A11 TGFBI
16 corneal endothelial dystrophy 10.7 COL8A2 SLC4A11 TGFBI
17 cartilage-hair hypoplasia 10.7 BAX BCL2 FASLG
18 bile duct carcinoma 10.7 FASLG KRT20 MUC1
19 bile duct cystadenocarcinoma 10.7 KRT20 MUC1
20 intraocular pressure quantitative trait locus 10.6 PITX2 ZEB1
21 intratubular embryonal carcinoma 10.6 KRT20 TCF4
22 corneal dystrophy, posterior polymorphous, 2 10.5 COL8A2 SLC4A11 VSX1 ZEB1
23 corneal dystrophy, posterior polymorphous, 3 10.5 COL8A2 SLC4A11 VSX1 ZEB1
24 basal cell carcinoma 10.5 BAX BCL2 FASLG KRT20
25 malignant teratoma 10.4 BAX BCL2
26 gastric adenocarcinoma 10.4 BAX BCL2 FASLG KRT20
27 keratopathy 10.3
28 bullous keratopathy 10.3
29 corneal degeneration 10.3 TGFBI VSX1
30 cataract 10.3
31 keratoconus 10.1
32 corneal disease 10.1 AGBL1 COL8A2 SLC4A11 TGFBI VSX1 ZEB1
33 aging 9.9
34 blepharospasm 9.9

Graphical network of the top 20 diseases related to Fuchs' Endothelial Dystrophy:



Diseases related to Fuchs' Endothelial Dystrophy

Symptoms & Phenotypes for Fuchs' Endothelial Dystrophy

MGI Mouse Phenotypes related to Fuchs' Endothelial Dystrophy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.65 AGBL1 BAX BCL2 CLU FASLG PITX2
2 vision/eye MP:0005391 9.32 BAX BCL2 COL8A2 FASLG PITX2 SLC4A11

Drugs & Therapeutics for Fuchs' Endothelial Dystrophy

Drugs for Fuchs' Endothelial Dystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loteprednol Approved Phase 4 82034-46-6, 129260-79-3 444025 9865442
2
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
3
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
4 Anti-Allergic Agents Phase 4,Phase 2
5 Antiemetics Phase 4,Phase 2
6 Anti-Inflammatory Agents Phase 4,Phase 2
7 Antineoplastic Agents, Hormonal Phase 4,Phase 2
8 Autonomic Agents Phase 4,Phase 2
9 Gastrointestinal Agents Phase 4,Phase 2
10 glucocorticoids Phase 4,Phase 2
11 Hormone Antagonists Phase 4,Phase 2
12 Hormones Phase 4,Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
14 Methylprednisolone acetate Phase 4,Phase 2
15 Methylprednisolone Hemisuccinate Phase 4,Phase 2
16 Neuroprotective Agents Phase 4,Phase 2
17 Ophthalmic Solutions Phase 4,Phase 3
18 Peripheral Nervous System Agents Phase 4,Phase 2
19 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
20 Prednisolone acetate Phase 4,Phase 2
21 Prednisolone hemisuccinate Phase 4,Phase 2
22 Prednisolone phosphate Phase 4,Phase 2
23 Protective Agents Phase 4,Phase 2
24 Tetrahydrozoline Phase 3
25
Fluorometholone Approved, Investigational Phase 2 426-13-1 9878
26
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
27 BB 1101 Phase 2
28 Dexamethasone acetate Phase 2 1177-87-3
29 HIV Protease Inhibitors Phase 2
30
protease inhibitors Phase 2
31
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
32 Adjuvants, Immunologic
33 Viscosupplements

Interventional clinical trials:

(show all 37)
# Name Status NCT ID Phase Drugs
1 Fuchs' Torsional Phaco Study Completed NCT00781027 Phase 4
2 Comparison of Corticosteroid Dosing Regimens After Endothelial Keratoplasty Completed NCT01853696 Phase 4 loteprednol etabonate;prednisolone acetate 1%
3 Intrastromal Corneal Ring for High Astigmatism on Postkeratoplasty Completed NCT01018797 Phase 4
4 Glanatec(R) for Descemet Stripping in Fuch's Endothelial Dystrophy Recruiting NCT03249337 Phase 4 Ripasudil hydrochloride hydrate 0.4% ophthalmic solution
5 Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation Recruiting NCT03248037 Phase 3 Netarsudil;Placebo
6 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2 Prednisolone acetate;Fluorometholone
7 Ripasudil 0.4% Eye Drops in Fuchs Endothelial Corneal Dystrophy Recruiting NCT03575130 Phase 2 Ripasudil eye drops;Optive eye drops
8 Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot Study Recruiting NCT02834260 Phase 2 Dexamethasone implant OZURDEX
9 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075 Not Applicable
10 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584 Not Applicable
11 Cornea Donor Study Unknown status NCT00006411 Not Applicable
12 DSAEK- Postoperative Positioning and Transplant Dislocation Unknown status NCT01206127 Not Applicable
13 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044 Not Applicable
14 Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty Unknown status NCT00744796 Not Applicable
15 ODM 5 in the Treatment of Corneal Edematous Fuchs' Endothelial Dystrophy Completed NCT02332109
16 Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and Pathology Completed NCT01979250 Not Applicable
17 The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal Dystrophy Completed NCT01795001
18 Comparison of Two Techniques in Achieving Corneal Graft Completed NCT01610973 Not Applicable
19 Combined Cataract Surgery and Planned Descemetorhexis Completed NCT02206594 Not Applicable
20 Long Term Cornea Graft Survival Study Completed NCT02849808
21 Study of Eye Bank Pre-cut Donor Grafts for Endothelial Keratoplasty Completed NCT00624221 Not Applicable
22 Impact of Cataract Surgery on Keratoplasty Graft Survival Completed NCT02875145
23 A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal Edema Completed NCT00346138 Not Applicable
24 PIONEER: Intraoperative and Perioperative OCT Study Completed NCT02423161
25 The German Keratoplasty Registry of the German Ophthalmological Society (DOG) Completed NCT03381794
26 Evaluation of the Efficacy of Descemet Membrane Transplantation for the Treatment of Fuchs' Endothelial Dystrophy Recruiting NCT03275896 Early Phase 1
27 Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT Recruiting NCT02542644 Not Applicable
28 DMEK Versus DSAEK Study Recruiting NCT02793310 Not Applicable
29 Novel Diagnostics With Optical Coherence Tomography: Imaging the Anterior Eye Recruiting NCT00343473
30 Technique And Results In Endothelial Keratoplasty Recruiting NCT02470793 Not Applicable
31 Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK) Recruiting NCT03407755 Not Applicable
32 Study of Endothelial Keratoplasty Outcomes Recruiting NCT00800111 Not Applicable
33 DISCOVER Study: Microscope-integrated Intraoperative OCT Study Recruiting NCT02423213
34 OCT-guided DSAEK Graft Shaping and Smoothing Terminated NCT01586234 Not Applicable
35 Using the Optovue OCT to Select IOL Power Terminated NCT01361282
36 Study of the Effect of Aspheric Lenses in Patients With Fuch's Dystrophy Withdrawn NCT02109276 Not Applicable
37 Specular Microscopy Study Withdrawn NCT02478970 Not Applicable

Search NIH Clinical Center for Fuchs' Endothelial Dystrophy

Cochrane evidence based reviews: fuchs' endothelial dystrophy

Genetic Tests for Fuchs' Endothelial Dystrophy

Genetic tests related to Fuchs' Endothelial Dystrophy:

# Genetic test Affiliating Genes
1 Fuchs Endothelial Corneal Dystrophy 29

Anatomical Context for Fuchs' Endothelial Dystrophy

MalaCards organs/tissues related to Fuchs' Endothelial Dystrophy:

41
Endothelial, Eye

Publications for Fuchs' Endothelial Dystrophy

Articles related to Fuchs' Endothelial Dystrophy:

(show top 50) (show all 185)
# Title Authors Year
1
Quarter-Descemet membrane endothelial keratoplasty (Quarter-DMEK) for Fuchs endothelial corneal dystrophy: 6 months clinical outcome. ( 29343529 )
2018
2
Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy. ( 29677349 )
2018
3
Analysis of candidate genes ZEB1 and LOXHD1 in late-onset Fuchs' endothelial corneal dystrophy in an Indian cohort. ( 29799290 )
2018
4
Gene Editing as a Potential Therapeutic Solution for Fuchs Endothelial Corneal Dystrophy: The Future Is Clearer. ( 29931030 )
2018
5
Primary Descemet's Membrane Endothelial Keratoplasty for Fuchs Endothelial Dystrophy versus Bullous Keratopathy: Histopathology and Clinical Results. ( 29939775 )
2018
6
Function-Related Protein Expression in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Models. ( 29698634 )
2018
7
Outcomes of conventional phacoemulsification versus femtosecond laser-assisted cataract surgery in eyes with Fuchs endothelial corneal dystrophy. ( 29773458 )
2018
8
Gene expression in the corneal endothelium of Fuchs endothelial corneal dystrophy patients with and without expansion of a trinucleotide repeat in TCF4. ( 29966009 )
2018
9
Corneal Optical Changes Associated with Induced Edema in Fuchs Endothelial Corneal Dystrophy. ( 29408827 )
2018
10
Hyperopic Trend after Cataract Surgery in Eyes with Fuchs' Endothelial Corneal Dystrophy. ( 29716785 )
2018
11
Pathological molecular mechanism of symptomatic late-onset Fuchs endothelial corneal dystrophy by bioinformatic analysis. ( 29787599 )
2018
12
Medical and Semi-surgical Treatments for Fuchs Endothelial Corneal Dystrophy. ( 29723889 )
2018
13
Association of the Gutta-Induced Microenvironment With Corneal Endothelial Cell Behavior and Demise in Fuchs Endothelial Corneal Dystrophy. ( 29852040 )
2018
14
Evolving therapies for Fuchs' endothelial dystrophy. ( 29360003 )
2018
15
Feasibility of cell-based therapy combined with descemetorhexis for treating Fuchs endothelial corneal dystrophy in rabbit model. ( 29338061 )
2018
16
Regenerative Therapy for Fuchs Endothelial Corneal Dystrophy. ( 29384808 )
2018
17
Femtosecond laser-assisted cataract surgery in Fuchs' endothelial corneal dystrophy: Long-term outcomes. ( 29958766 )
2018
18
Fuchs endothelial corneal dystrophy and macular drusen: evidence for coincidence? ( 29350686 )
2018
19
NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy. ( 29294389 )
2018
20
DMEK versus DSAEK for Fuchs' endothelial dystrophy: A meta-analysis. ( 29661044 )
2018
21
Factors Influencing Visual Acuity in Fuchs' Endothelial Corneal Dystrophy. ( 29252902 )
2018
22
Trinucleotide Repeat Expansion in the Transcription Factor 4 (TCF4) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy. ( 28118661 )
2017
23
Corneal Backscatters as an Objective Index for Assessing Fuchs' Endothelial Corneal Dystrophy: A Pilot Study. ( 28751984 )
2017
24
Peripheral Endothelial Cell Count Is a Predictor of Disease Severity in Advanced Fuchs Endothelial Corneal Dystrophy. ( 28731879 )
2017
25
Association of polymorphisms in the intron of TCF4 gene to late-onset Fuchs endothelial corneal dystrophy: An Indian cohort study. ( 29044056 )
2017
26
Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy. ( 28886202 )
2017
27
Study of light scattering using C-Quant(Ar) in patients with Fuchs' endothelial dystrophy: A pilot study. ( 28320557 )
2017
28
Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy. ( 28727885 )
2017
29
Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy. ( 28751712 )
2017
30
Extracellular Matrix and Integrin Expression Profiles in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Model. ( 28726551 )
2017
31
Mini descemet membrane stripping (m-DMES) in patients with Fuchs' endothelial dystrophy: A new method. ( 29234234 )
2017
32
Activation of TGF-I^ signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy. ( 28754918 )
2017
33
TGC repeat expansion in the TCF4 gene increases the risk of Fuchs' endothelial corneal dystrophy in Australian cases. ( 28832669 )
2017
34
Author Response: Transforming Growth Factor Beta Switch in Aqueous Humor of Patients With Fuchs' Endothelial Corneal Dystrophy. ( 26927571 )
2016
35
Changes in Corneal Densitometry in Patients with Fuchs Endothelial Dystrophy after Endothelial Keratoplasty. ( 27260144 )
2016
36
Fuchs Endothelial Corneal Dystrophy: A Systematic Immunofluorescence Study of Collagen Type VIII Suggests Heterogeneous Pathophysiology. ( 27078008 )
2016
37
Coenzyme Q10 in the Treatment of Corneal Edema in Kearns-Sayre: Is There an Application in Fuchs Endothelial Corneal Dystrophy? ( 27442316 )
2016
38
Preliminary outcome of hemi-Descemet membrane endothelial keratoplasty for Fuchs endothelial dystrophy. ( 26837507 )
2016
39
Treatment of Fuchs Endothelial Dystrophy by Descemet Stripping Without Endothelial Keratoplasty. ( 27310885 )
2016
40
The Ultrastructures and Mechanical Properties of the Descement's Membrane in Fuchs Endothelial Corneal Dystrophy. ( 26980551 )
2016
41
[TGC Repeats in Intron 2 of the TCF4 Gene have a Good Predictive Power Regarding to Fuchs Endothelial Corneal Dystrophy]. ( 26280645 )
2016
42
Descemet Stripping Automated Endothelial Keratoplasty in Fuchs' Endothelial Dystrophy versus Pseudophakic Bullous Keratopathy. ( 27994806 )
2016
43
Changes in Corneal Refractive Power for Patients With Fuchs Endothelial Dystrophy After DMEK. ( 27055217 )
2016
44
Case Report of Quarter-Descemet Membrane Endothelial Keratoplasty for Fuchs Endothelial Dystrophy. ( 27583798 )
2016
45
Evaluation of Endothelial Pump Function in Fuchs Endothelial Dystrophy Before and After Endothelial Keratoplasty. ( 27055221 )
2016
46
Corneal Densitometry, Central Corneal Thickness, and Corneal Central-to-Peripheral Thickness Ratio in Patients With Fuchs Endothelial Dystrophy. ( 26655484 )
2016
47
Menadione-Induced DNA Damage Leads to Mitochondrial Dysfunction and Fragmentation During Rosette Formation in Fuchs Endothelial Corneal Dystrophy. ( 26935406 )
2016
48
Evaluation of Visual Quality in Patients With Fuchs Endothelial Corneal Dystrophy. ( 27631348 )
2016
49
In Vivo Imaging of Corneal Endothelial Dystrophy in Boston Terriers: A Spontaneous, Canine Model for Fuchs' Endothelial Corneal Dystrophy. ( 27454658 )
2016
50
Existence of Neural Crest-Derived Progenitor Cells in Normal and Fuchs Endothelial Dystrophy Corneal Endothelium. ( 27639969 )
2016

Variations for Fuchs' Endothelial Dystrophy

Expression for Fuchs' Endothelial Dystrophy

Search GEO for disease gene expression data for Fuchs' Endothelial Dystrophy.

Pathways for Fuchs' Endothelial Dystrophy

GO Terms for Fuchs' Endothelial Dystrophy

Cellular components related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pore complex GO:0046930 8.62 BAX BCL2

Biological processes related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.88 BAX BCL2 CLU FASLG KRT20 PRDX5
2 regulation of apoptotic process GO:0042981 9.86 BAX BCL2 CLU PRDX2
3 cytokine-mediated signaling pathway GO:0019221 9.84 BCL2 FASLG MUC1 ZEB1
4 male gonad development GO:0008584 9.7 BAX BCL2 PITX2
5 cellular oxidant detoxification GO:0098869 9.65 LOXHD1 PRDX2 PRDX5
6 hydrogen peroxide catabolic process GO:0042744 9.55 PRDX2 PRDX5
7 endoplasmic reticulum calcium ion homeostasis GO:0032469 9.51 BAX BCL2
8 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.5 BAX BCL2 FASLG
9 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.49 BAX FASLG
10 regulation of protein heterodimerization activity GO:0043497 9.46 BAX BCL2
11 regulation of protein homodimerization activity GO:0043496 9.43 BAX BCL2
12 leukocyte homeostasis GO:0001776 9.37 BAX BCL2
13 regulation of nitrogen utilization GO:0006808 9.26 BAX BCL2
14 positive regulation of developmental pigmentation GO:0048087 9.16 BAX BCL2
15 retinal cell programmed cell death GO:0046666 8.96 BAX FASLG
16 release of cytochrome c from mitochondria GO:0001836 8.8 BAX BCL2 CLU

Molecular functions related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxiredoxin activity GO:0051920 9.16 PRDX2 PRDX5
2 BH3 domain binding GO:0051434 8.96 BAX BCL2
3 thioredoxin peroxidase activity GO:0008379 8.62 PRDX2 PRDX5

Sources for Fuchs' Endothelial Dystrophy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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44 MeSH
45 MESH via Orphanet
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49 NCI
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51 NDF-RT
54 NINDS
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58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
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74 UMLS via Orphanet
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