FCED
MCID: FCH001
MIFTS: 49

Fuchs' Endothelial Dystrophy (FCED)

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Fuchs' Endothelial Dystrophy

MalaCards integrated aliases for Fuchs' Endothelial Dystrophy:

Name: Fuchs' Endothelial Dystrophy 12 25 44 15
Fuchs Endothelial Corneal Dystrophy 53 25 59 29
Late Hereditary Endothelial Dystrophy 53 59
Endoepithelial Corneal Dystrophy 53 59
Fuchs Endothelial Dystrophy 25 73
Fuchs Corneal Dystrophy 25 37
Fuchs Dystrophy 25 55
Fecd 53 59
Corneal Dystrophy, Fuchs' Endothelial, 1 73
Dystrophy, Corneal, Fuchs Endothelial 40
Fuchs' Endothelial Corneal Dystrophy 12
Corneal Dystrophy, Fuchs Endothelial 55
Fuchs' Corneal Dystrophy 12
Fuchs Atrophy 25
Fced 12

Characteristics:

Orphanet epidemiological data:

59
fuchs endothelial corneal dystrophy
Inheritance: Autosomal dominant,Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:11555
ICD10 33 H18.51
MeSH 44 D005642
NCIt 50 C84721
SNOMED-CT 68 16949007
Orphanet 59 ORPHA98974
UMLS via Orphanet 74 C0016781
ICD10 via Orphanet 34 H18.5
KEGG 37 H00960

Summaries for Fuchs' Endothelial Dystrophy

NIH Rare Diseases : 53 Fuchs endothelial corneal dystrophy (FECD) is an eye disease. It affects the thin layer of cells that line the back part of the cornea. This layer is called the endothelium. The disease occurs when these cells slowly start to die off. The cells help pump excess fluid out of the cornea. As more and more cells are lost, fluid begins to build up in the cornea, causing swelling and a cloudy cornea. There are several forms of the disease according to the age of onset of the symptoms and the cause. The early-onset form is very rare and is known as Fuchs endothelial corneal dystrophy 1 (or early-onset Fuchs endothelial corneal dystrophy) and it is caused by a change (mutation) in the COL8A2 gene. Late-onset Fuchs endothelial corneal dystrophies are common and include:Fuchs endothelial corneal dystrophy 2 (caused by a mutation in an unknown gene located in chromosome13) Fuchs endothelial corneal dystrophy 3 (may be caused by TCF4 gene mutations) Fuchs endothelial corneal dystrophy 4 (caused by a mutation in the SLC4A11 gene) Fuchs endothelial corneal dystrophy 5 (caused by a mutation in an unknown gene located in chromosome 15) Fuchs endothelial corneal dystrophy 6 (caused by a mutation in the ZEB1 gene) Fuchs endothelial corneal dystrophy 7 (caused by a mutation in an unknown gene located in chromosome 9) Fuchs endothelial corneal dystrophy 8 (caused by heterozygous mutation in the AGBL1 gene).  Early in the disease, patients typically do not have symptoms. In the late-onset forms, the symptoms start around 50 or 60 years and include discomfort and painful episodes of recurrent corneal wounds and hazy vision. Over time, discomfort may diminish but severe impairment of visual acuity, and even blindness and cataracts in elderly patients, may be observed. Once the vision has worsened, the recommended treatment is a penetrating graft which has excellent results in most cases.

MalaCards based summary : Fuchs' Endothelial Dystrophy, also known as fuchs endothelial corneal dystrophy, is related to corneal endothelial dystrophy and corneal dystrophy, posterior polymorphous, 3. An important gene associated with Fuchs' Endothelial Dystrophy is COL8A2 (Collagen Type VIII Alpha 2 Chain), and among its related pathways/superpathways are DNA Damage Response (only ATM dependent) and Nanomaterial induced apoptosis. The drugs Prednisolone and Prednisolone phosphate have been mentioned in the context of this disorder. Affiliated tissues include endothelial, eye and colon, and related phenotypes are immune system and vision/eye

Disease Ontology : 12 A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of Descemet's membrane, leading to corneal edema and loss of vision.

Related Diseases for Fuchs' Endothelial Dystrophy

Diseases related to Fuchs' Endothelial Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 corneal endothelial dystrophy 30.6 COL8A2 SLC4A11 TGFBI
2 corneal dystrophy, posterior polymorphous, 3 30.5 COL8A2 SLC4A11 VSX1 ZEB1
3 corneal dystrophy, posterior polymorphous, 1 30.4 COL8A2 SLC4A11 TGFBI VSX1 ZEB1
4 corneal dystrophy 30.3 AGBL1 COL8A2 LOXHD1 SLC4A11 TCF4 TGFBI
5 corneal dystrophy, fuchs endothelial, 7 12.6
6 corneal dystrophy, fuchs endothelial, 1 12.3
7 corneal dystrophy, fuchs endothelial, 4 11.6
8 corneal dystrophy, fuchs endothelial, 6 11.6
9 corneal dystrophy, fuchs endothelial, 8 11.4
10 corneal dystrophy, fuchs endothelial, 5 11.3
11 cataract 10.4
12 keratopathy 10.4
13 bullous keratopathy 10.4
14 myotonic dystrophy 10.4
15 myotonia atrophica 10.4
16 keratoconus 10.3
17 chronic venous leg ulcers 10.2 BCL2 FASLG
18 corneal dystrophy, endothelial, x-linked 10.2 SLC4A11 VSX1
19 intratubular embryonal carcinoma 10.2 KRT20 TCF4
20 anterior segment dysgenesis 10.2 PITX2 TGFBI VSX1
21 corneal dystrophy, thiel-behnke type 10.2 COL8A2 SLC4A11 TGFBI
22 cartilage-hair hypoplasia 10.2 BAX BCL2 FASLG
23 kashin-beck disease 10.2 BAX BCL2
24 bile duct cystadenocarcinoma 10.2 KRT20 MUC1
25 bile duct adenoma 10.2 KRT20 MUC1
26 corneal dystrophy, posterior polymorphous, 2 10.2 COL8A2 SLC4A11 VSX1 ZEB1
27 corneal dystrophy, epithelial basement membrane 10.1
28 myotonic dystrophy 1 10.1
29 ocular hypertension 10.1
30 posterior cortical atrophy 10.1
31 basal cell carcinoma 10.1 BAX BCL2 FASLG KRT20
32 adamantinoma of long bones 10.1 BAX BCL2 PITX2 ZEB1
33 malignant teratoma 10.1 BAX BCL2
34 gastric adenocarcinoma 10.1 BAX BCL2 FASLG KRT20 MUC1
35 large intestine cancer 10.1 FASLG KRT20 MUC1 ZEB1
36 astigmatism 10.1
37 corneal dystrophy, fuchs endothelial, 2 10.1
38 corneal dystrophy, fuchs endothelial, 3 10.1
39 corneal degeneration 10.1 TGFBI VSX1
40 aging 10.0
41 corneal edema 10.0
42 blepharospasm 10.0
43 corneal disease 10.0 AGBL1 COL8A2 SLC4A11 TGFBI VSX1 ZEB1
44 corneal ectasia 10.0

Graphical network of the top 20 diseases related to Fuchs' Endothelial Dystrophy:



Diseases related to Fuchs' Endothelial Dystrophy

Symptoms & Phenotypes for Fuchs' Endothelial Dystrophy

MGI Mouse Phenotypes related to Fuchs' Endothelial Dystrophy:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.65 AGBL1 BAX BCL2 CLU FASLG PITX2
2 vision/eye MP:0005391 9.32 BAX BCL2 COL8A2 FASLG PITX2 SLC4A11

Drugs & Therapeutics for Fuchs' Endothelial Dystrophy

Drugs for Fuchs' Endothelial Dystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prednisolone Approved, Vet_approved Phase 4,Phase 2 50-24-8 5755
2
Prednisolone phosphate Approved, Vet_approved Phase 4,Phase 2 302-25-0
3
Methylprednisolone hemisuccinate Approved Phase 4,Phase 2 2921-57-5
4
Loteprednol Approved, Experimental Phase 4 82034-46-6, 129260-79-3 9865442 444025
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 2 83-43-2 6741
6
Prednisolone hemisuccinate Experimental Phase 4,Phase 2 2920-86-7
7 Gastrointestinal Agents Phase 4,Phase 2
8 Methylprednisolone acetate Phase 4,Phase 2
9 Prednisolone acetate Phase 4,Phase 2
10 Anti-Allergic Agents Phase 4,Phase 2
11 Antineoplastic Agents, Hormonal Phase 4,Phase 2
12 Neuroprotective Agents Phase 4,Phase 2
13 Anti-Inflammatory Agents Phase 4,Phase 2
14 Protective Agents Phase 4,Phase 2
15 Hormone Antagonists Phase 4,Phase 2
16 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2
17 Antiemetics Phase 4,Phase 2
18 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2
19 Hormones Phase 4,Phase 2
20 Peripheral Nervous System Agents Phase 4,Phase 2
21 Autonomic Agents Phase 4,Phase 2
22 glucocorticoids Phase 4,Phase 2
23 Ophthalmic Solutions Phase 4,Phase 3,Phase 2
24
Fluorometholone Approved, Investigational Phase 2 426-13-1 9878
25
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
26
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
27 Lubricant Eye Drops Phase 2
28 BB 1101 Phase 2
29 HIV Protease Inhibitors Phase 2
30
protease inhibitors Phase 2
31
Hyaluronic acid Approved, Vet_approved 9004-61-9 53477741
32 Adjuvants, Immunologic
33 Viscosupplements
34 Immunologic Factors

Interventional clinical trials:

(show all 40)
# Name Status NCT ID Phase Drugs
1 Fuchs' Torsional Phaco Study Completed NCT00781027 Phase 4
2 Comparison of Corticosteroid Dosing Regimens After Endothelial Keratoplasty Completed NCT01853696 Phase 4 loteprednol etabonate;prednisolone acetate 1%
3 Intrastromal Corneal Ring for High Astigmatism on Postkeratoplasty Completed NCT01018797 Phase 4
4 Glanatec(R) for Descemet Stripping in Fuch's Endothelial Dystrophy Recruiting NCT03249337 Phase 4 Ripasudil hydrochloride hydrate 0.4% ophthalmic solution
5 Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation Active, not recruiting NCT03248037 Phase 3 Netarsudil;Placebo
6 Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK) Completed NCT01448213 Phase 2 Prednisolone acetate;Fluorometholone
7 Ripasudil 0.4% Eye Drops in Fuchs Endothelial Corneal Dystrophy Recruiting NCT03575130 Phase 2 Ripasudil eye drops;Optive eye drops
8 Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot Study Recruiting NCT02834260 Phase 2 Dexamethasone implant OZURDEX
9 Ripasudil for Enhanced Corneal Clearing Following Descemet Membrane Endothelial Keratoplasty in Fuchs' Dystrophy Not yet recruiting NCT03813056 Phase 2 Glanatec;Optive, Ophthalmic Solution
10 Comparing Endoglide to Endoserter for DSAEK Graft Insertion Unknown status NCT01791075 Not Applicable
11 Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media Unknown status NCT00623584 Not Applicable
12 Cornea Donor Study Unknown status NCT00006411 Not Applicable
13 DSAEK- Postoperative Positioning and Transplant Dislocation Unknown status NCT01206127 Not Applicable
14 Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) Unknown status NCT02020044 Not Applicable
15 Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty Unknown status NCT00744796 Not Applicable
16 ODM 5 in the Treatment of Corneal Edematous Fuchs' Endothelial Dystrophy Completed NCT02332109
17 Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and Pathology Completed NCT01979250 Not Applicable
18 The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal Dystrophy Completed NCT01795001
19 Comparison of Two Techniques in Achieving Corneal Graft Completed NCT01610973 Not Applicable
20 Combined Cataract Surgery and Planned Descemetorhexis Completed NCT02206594 Not Applicable
21 Long Term Cornea Graft Survival Study Completed NCT02849808
22 Study of Eye Bank Pre-cut Donor Grafts for Endothelial Keratoplasty Completed NCT00624221 Not Applicable
23 Impact of Cataract Surgery on Keratoplasty Graft Survival Completed NCT02875145
24 A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal Edema Completed NCT00346138 Not Applicable
25 Study of Endothelial Keratoplasty Outcomes Completed NCT00800111 Not Applicable
26 PIONEER: Intraoperative and Perioperative OCT Study Completed NCT02423161
27 The German Keratoplasty Registry of the German Ophthalmological Society (DOG) Completed NCT03381794
28 Evaluation of the Efficacy of Descemet Membrane Transplantation for the Treatment of Fuchs' Endothelial Dystrophy Recruiting NCT03275896 Early Phase 1
29 Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT Recruiting NCT02542644 Not Applicable
30 DMEK Versus DSAEK Study Recruiting NCT02793310 Not Applicable
31 Novel Diagnostics With Optical Coherence Tomography: Imaging the Anterior Eye Recruiting NCT00343473
32 Technique And Results In Endothelial Keratoplasty Recruiting NCT02470793 Not Applicable
33 Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK) Recruiting NCT03407755 Not Applicable
34 The ADVISE Study: Advanced Visualization In Corneal Surgery Evaluation Recruiting NCT03763721 Not Applicable
35 DISCOVER Study: Microscope-integrated Intraoperative OCT Study Recruiting NCT02423213
36 Femtolaser Assisted Keratoplasty Versus Conventional Keratoplasty Not yet recruiting NCT03619434 Not Applicable
37 OCT-guided DSAEK Graft Shaping and Smoothing Terminated NCT01586234 Not Applicable
38 Using the Optovue OCT to Select IOL Power Terminated NCT01361282
39 Study of the Effect of Aspheric Lenses in Patients With Fuch's Dystrophy Withdrawn NCT02109276 Not Applicable
40 Specular Microscopy Study Withdrawn NCT02478970 Not Applicable

Search NIH Clinical Center for Fuchs' Endothelial Dystrophy

Cochrane evidence based reviews: fuchs' endothelial dystrophy

Genetic Tests for Fuchs' Endothelial Dystrophy

Genetic tests related to Fuchs' Endothelial Dystrophy:

# Genetic test Affiliating Genes
1 Fuchs Endothelial Corneal Dystrophy 29

Anatomical Context for Fuchs' Endothelial Dystrophy

MalaCards organs/tissues related to Fuchs' Endothelial Dystrophy:

41
Endothelial, Eye, Colon, Ovary, Appendix

Publications for Fuchs' Endothelial Dystrophy

Articles related to Fuchs' Endothelial Dystrophy:

(show top 50) (show all 218)
# Title Authors Year
1
Quarter-Descemet membrane endothelial keratoplasty (Quarter-DMEK) for Fuchs endothelial corneal dystrophy: 6 months clinical outcome. ( 29343529 )
2018
2
Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy. ( 29677349 )
2018
3
Analysis of candidate genes ZEB1 and LOXHD1 in late-onset Fuchs' endothelial corneal dystrophy in an Indian cohort. ( 29799290 )
2018
4
Gene Editing as a Potential Therapeutic Solution for Fuchs Endothelial Corneal Dystrophy: The Future Is Clearer. ( 29931030 )
2018
5
Primary Descemet's Membrane Endothelial Keratoplasty for Fuchs Endothelial Dystrophy versus Bullous Keratopathy: Histopathology and Clinical Results. ( 29939775 )
2018
6
Function-Related Protein Expression in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Models. ( 29698634 )
2018
7
Outcomes of conventional phacoemulsification versus femtosecond laser-assisted cataract surgery in eyes with Fuchs endothelial corneal dystrophy. ( 29773458 )
2018
8
Gene expression in the corneal endothelium of Fuchs endothelial corneal dystrophy patients with and without expansion of a trinucleotide repeat in TCF4. ( 29966009 )
2018
9
Corneal Optical Changes Associated with Induced Edema in Fuchs Endothelial Corneal Dystrophy. ( 29408827 )
2018
10
Hyperopic Trend after Cataract Surgery in Eyes with Fuchs' Endothelial Corneal Dystrophy. ( 29716785 )
2018
11
Pathological molecular mechanism of symptomatic late-onset Fuchs endothelial corneal dystrophy by bioinformatic analysis. ( 29787599 )
2018
12
Medical and Semi-surgical Treatments for Fuchs Endothelial Corneal Dystrophy. ( 29723889 )
2018
13
Association of the Gutta-Induced Microenvironment With Corneal Endothelial Cell Behavior and Demise in Fuchs Endothelial Corneal Dystrophy. ( 29852040 )
2018
14
Evolving therapies for Fuchs' endothelial dystrophy. ( 29360003 )
2018
15
Feasibility of cell-based therapy combined with descemetorhexis for treating Fuchs endothelial corneal dystrophy in rabbit model. ( 29338061 )
2018
16
Regenerative Therapy for Fuchs Endothelial Corneal Dystrophy. ( 29384808 )
2018
17
Femtosecond laser-assisted cataract surgery in Fuchs' endothelial corneal dystrophy: Long-term outcomes. ( 29958766 )
2018
18
Fuchs endothelial corneal dystrophy and macular drusen: evidence for coincidence? ( 29350686 )
2018
19
NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy. ( 29294389 )
2018
20
DMEK versus DSAEK for Fuchs' endothelial dystrophy: A meta-analysis. ( 29661044 )
2018
21
Comparing Outcomes of Phacoemulsification With Femtosecond Laser-Assisted Cataract Surgery in Patients With Fuchs Endothelial Dystrophy. ( 30098347 )
2018
22
Factors Influencing Visual Acuity in Fuchs' Endothelial Corneal Dystrophy. ( 29252902 )
2018
23
Outcomes of Hemi-Descemet Membrane Endothelial Keratoplasty for Fuchs Endothelial Corneal Dystrophy. ( 29557816 )
2018
24
Fuchs Endothelial Corneal Dystrophy: Update on Pathogenesis and Future Directions. ( 30005051 )
2018
25
Fuchs' Endothelial Corneal Dystrophy in Patients With Myotonic Dystrophy, Type 1. ( 30025114 )
2018
26
Instability of TCF4 Triplet Repeat Expansion With Parent-Child Transmission in Fuchs' Endothelial Corneal Dystrophy. ( 30098193 )
2018
27
Patient-Reported Visual Disability in Fuchs' Endothelial Corneal Dystrophy Measured by the Visual Function and Corneal Health Status Instrument. ( 30104038 )
2018
28
Perspective of Future Potent Therapies for Fuchs Endothelial Corneal Dystrophy. ( 30123380 )
2018
29
Determining Subclinical Edema in Fuchs Endothelial Corneal Dystrophy. Revised Classification using Scheimpflug Tomography for Preoperative Assessment. ( 30153944 )
2018
30
In Vivo Confocal Microscopy Shows Alterations in Nerve Density and Dendritiform Cell Density in Fuchs' Endothelial Corneal Dystrophy. ( 30194928 )
2018
31
Descemetorhexis Without Endothelial Keratoplasty Versus DMEK for Treatment of Fuchs Endothelial Corneal Dystrophy. ( 30222714 )
2018
32
Fuchs Endothelial Corneal Dystrophy and Mitochondria. ( 30252683 )
2018
33
rs4246215 is targeted by hsa-miR1236 to regulate FEN1 expression but is not associated with Fuchs' endothelial corneal dystrophy. ( 30260965 )
2018
34
Fuchs Endothelial Corneal Dystrophy Through the Prism of Oxidative Stress. ( 30299369 )
2018
35
Biomechanical changes to Descemet's membrane precede endothelial cell loss in an early-onset murine model of Fuchs endothelial corneal dystrophy. ( 30471280 )
2018
36
Corneal endothelium features in Fuchs' Endothelial Corneal Dystrophy: A preliminary 3D anterior segment optical coherence tomography study. ( 30496218 )
2018
37
A Historical Perspective on Treatment of Fuchs' Endothelial Dystrophy: We have Come a Long Way. ( 30090191 )
2018
38
Predictive Factors for Clinical Outcomes after Primary Descemet's Membrane Endothelial Keratoplasty for Fuchs' Endothelial Dystrophy. ( 30339062 )
2018
39
Scanning Acoustic Microscopy Comparison of Descemet's Membrane Normal Tissue and Tissue With Fuchs' Endothelial Dystrophy. ( 30481279 )
2018
40
Trinucleotide Repeat Expansion in the Transcription Factor 4 (TCF4) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy. ( 28118661 )
2017
41
Corneal Backscatters as an Objective Index for Assessing Fuchs' Endothelial Corneal Dystrophy: A Pilot Study. ( 28751984 )
2017
42
Peripheral Endothelial Cell Count Is a Predictor of Disease Severity in Advanced Fuchs Endothelial Corneal Dystrophy. ( 28731879 )
2017
43
Association of polymorphisms in the intron of TCF4 gene to late-onset Fuchs endothelial corneal dystrophy: An Indian cohort study. ( 29044056 )
2017
44
Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy. ( 28886202 )
2017
45
Study of light scattering using C-Quant(Ar) in patients with Fuchs' endothelial dystrophy: A pilot study. ( 28320557 )
2017
46
Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy. ( 28727885 )
2017
47
Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy. ( 28751712 )
2017
48
Extracellular Matrix and Integrin Expression Profiles in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Model. ( 28726551 )
2017
49
Mini descemet membrane stripping (m-DMES) in patients with Fuchs' endothelial dystrophy: A new method. ( 29234234 )
2017
50
Activation of TGF-I^ signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy. ( 28754918 )
2017

Variations for Fuchs' Endothelial Dystrophy

Expression for Fuchs' Endothelial Dystrophy

Search GEO for disease gene expression data for Fuchs' Endothelial Dystrophy.

Pathways for Fuchs' Endothelial Dystrophy

GO Terms for Fuchs' Endothelial Dystrophy

Cellular components related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 pore complex GO:0046930 8.62 BAX BCL2

Biological processes related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 apoptotic process GO:0006915 9.88 BAX BCL2 CLU FASLG KRT20 PRDX5
2 cytokine-mediated signaling pathway GO:0019221 9.81 BCL2 FASLG MUC1 ZEB1
3 cellular oxidant detoxification GO:0098869 9.65 LOXHD1 PRDX2 PRDX5
4 B cell homeostasis GO:0001782 9.55 BAX BCL2
5 apoptotic mitochondrial changes GO:0008637 9.54 BAX BCL2
6 negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 9.52 BCL2 MUC1
7 extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 9.5 BAX BCL2 FASLG
8 endoplasmic reticulum calcium ion homeostasis GO:0032469 9.49 BAX BCL2
9 regulation of protein heterodimerization activity GO:0043497 9.46 BAX BCL2
10 regulation of protein homodimerization activity GO:0043496 9.43 BAX BCL2
11 leukocyte homeostasis GO:0001776 9.37 BAX BCL2
12 positive regulation of developmental pigmentation GO:0048087 9.26 BAX BCL2
13 regulation of nitrogen utilization GO:0006808 9.16 BAX BCL2
14 retinal cell programmed cell death GO:0046666 8.96 BAX FASLG
15 release of cytochrome c from mitochondria GO:0001836 8.8 BAX BCL2 CLU

Molecular functions related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peroxiredoxin activity GO:0051920 9.16 PRDX2 PRDX5
2 BH3 domain binding GO:0051434 8.96 BAX BCL2
3 thioredoxin peroxidase activity GO:0008379 8.62 PRDX2 PRDX5

Sources for Fuchs' Endothelial Dystrophy

3 CDC
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34 ICD10 via Orphanet
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