Fuchs' Endothelial Dystrophy disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: FCH001 MIFTS: 49	Fuchs' Endothelial Dystrophy Categories: Rare diseases, Eye diseases
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Aliases & Classifications for Fuchs' Endothelial Dystrophy

MalaCards integrated aliases for Fuchs' Endothelial Dystrophy:

Name: Fuchs' Endothelial Dystrophy ¹² ²⁵ ⁴⁴ ¹⁵

Fuchs Endothelial Corneal Dystrophy ⁵³ ²⁵ ⁵⁹ ²⁹

Late Hereditary Endothelial Dystrophy ⁵³ ⁵⁹

Endoepithelial Corneal Dystrophy ⁵³ ⁵⁹

Fuchs Endothelial Dystrophy ²⁵ ⁷³

Fuchs Corneal Dystrophy ²⁵ ³⁷

Fuchs Dystrophy ²⁵ ⁵⁵

Fecd ⁵³ ⁵⁹

Corneal Dystrophy, Fuchs' Endothelial, 1 ⁷³

Dystrophy, Corneal, Fuchs Endothelial ⁴⁰

Fuchs' Endothelial Corneal Dystrophy ¹²

Corneal Dystrophy, Fuchs Endothelial ⁵⁵

Fuchs' Corneal Dystrophy ¹²

Fuchs Atrophy ²⁵

Fced ¹²

Characteristics:

Orphanet epidemiological data:

⁵⁹

fuchs endothelial corneal dystrophy
Inheritance: Autosomal dominant,Multigenic/multifactorial,Not applicable; Age of onset: Adult;

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

ICD10: ³⁴

Diseases of the eye and adnexa

Disorders of sclera, cornea, iris and ciliary body

Other disorders of cornea

Hereditary corneal dystrophies

Orphanet: ⁵⁹

Rare eye diseases

External Ids:

Disease Ontology ¹² DOID:11555

ICD10 ³³ H18.51

MeSH ⁴⁴ D005642

NCIt ⁵⁰ C84721

SNOMED-CT ⁶⁸ 16949007 193839007 393581005

Orphanet ⁵⁹ ORPHA98974

UMLS via Orphanet ⁷⁴ C0016781

ICD10 via Orphanet ³⁴ H18.5

KEGG ³⁷ H00960

UMLS ⁷³ C0016781 C1850959

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Summaries for Fuchs' Endothelial Dystrophy

NIH Rare Diseases : ⁵³ Fuchs endothelial corneal dystrophy (FECD) is an eye disease. It affects the thin layer of cells that line the back part of the cornea. This layer is called the endothelium. The disease occurs when these cells slowly start to die off. The cells help pump excess fluid out of the cornea. As more and more cells are lost, fluid begins to build up in the cornea, causing swelling and a cloudy cornea. There are several forms of the disease according to the age of onset of the symptoms and the cause. The early-onset form is very rare and is known as Fuchs endothelial corneal dystrophy 1 (or early-onset Fuchs endothelial corneal dystrophy) and it is caused by a change (mutation) in the COL8A2 gene. Late-onset Fuchs endothelial corneal dystrophies are common and include:Fuchs endothelial corneal dystrophy 2 (caused by a mutation in an unknown gene located in chromosome13) Fuchs endothelial corneal dystrophy 3 (may be caused by TCF4 gene mutations) Fuchs endothelial corneal dystrophy 4 (caused by a mutation in the SLC4A11 gene) Fuchs endothelial corneal dystrophy 5 (caused by a mutation in an unknown gene located in chromosome 15) Fuchs endothelial corneal dystrophy 6 (caused by a mutation in the ZEB1 gene) Fuchs endothelial corneal dystrophy 7 (caused by a mutation in an unknown gene located in chromosome 9) Fuchs endothelial corneal dystrophy 8 (caused by heterozygous mutation in the AGBL1 gene). Early in the disease, patients typically do not have symptoms. In the late-onset forms, the symptoms start around 50 or 60 years and include discomfort and painful episodes of recurrent corneal wounds and hazy vision. Over time, discomfort may diminish but severe impairment of visual acuity, and even blindness and cataracts in elderly patients, may be observed. Once the vision has worsened, the recommended treatment is a penetrating graft which has excellent results in most cases.

MalaCards based summary : Fuchs' Endothelial Dystrophy, also known as fuchs endothelial corneal dystrophy, is related to corneal edema and corneal dystrophy, posterior polymorphous, 1. An important gene associated with Fuchs' Endothelial Dystrophy is COL8A2 (Collagen Type VIII Alpha 2 Chain), and among its related pathways/superpathways are DNA Damage Response (only ATM dependent) and Nanomaterial induced apoptosis. The drugs Loteprednol and Methylprednisolone have been mentioned in the context of this disorder. Affiliated tissues include endothelial and eye, and related phenotypes are immune system and vision/eye

Genetics Home Reference : ²⁵ Fuchs endothelial dystrophy is a condition that causes vision problems. The first symptom of this condition is typically blurred vision in the morning that usually clears during the day. Over time, affected individuals lose the ability to see details (visual acuity). People with Fuchs endothelial dystrophy also become sensitive to bright lights.

Disease Ontology : ¹² A corneal dystrophy characterized by accumulation of focal outgrowths (guttae) and thickening of Descemet's membrane, leading to corneal edema and loss of vision.

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Related Diseases for Fuchs' Endothelial Dystrophy

Diseases related to Fuchs' Endothelial Dystrophy via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)

#	Related Disease	Score	Top Affiliating Genes
1	corneal edema	31.0	COL8A2 SLC4A11 TGFBI
2	corneal dystrophy, posterior polymorphous, 1	30.8	COL8A2 SLC4A11 VSX1 ZEB1
3	corneal dystrophy	30.2	AGBL1 COL8A2 SLC4A11 TCF4 TGFBI VSX1
4	corneal dystrophy, fuchs endothelial, 3	12.0
5	corneal dystrophy, fuchs endothelial, 1	11.7
6	corneal dystrophy, fuchs endothelial, 2	11.4
7	corneal dystrophy, fuchs endothelial, 4	11.4
8	corneal dystrophy, fuchs endothelial, 6	11.4
9	corneal dystrophy, fuchs endothelial, 5	11.1
10	endotheliitis	10.8
11	corneal dystrophy, endothelial, x-linked	10.8	SLC4A11 VSX1
12	anterior segment dysgenesis	10.8	PITX2 TGFBI VSX1
13	kashin-beck disease	10.8	BAX BCL2
14	mucinous bronchioloalveolar adenocarcinoma	10.8	KRT20 MUC1
15	corneal dystrophy, thiel-behnke type	10.7	COL8A2 SLC4A11 TGFBI
16	corneal endothelial dystrophy	10.7	COL8A2 SLC4A11 TGFBI
17	cartilage-hair hypoplasia	10.7	BAX BCL2 FASLG
18	bile duct carcinoma	10.7	FASLG KRT20 MUC1
19	bile duct cystadenocarcinoma	10.7	KRT20 MUC1
20	intraocular pressure quantitative trait locus	10.6	PITX2 ZEB1
21	intratubular embryonal carcinoma	10.6	KRT20 TCF4
22	corneal dystrophy, posterior polymorphous, 2	10.5	COL8A2 SLC4A11 VSX1 ZEB1
23	corneal dystrophy, posterior polymorphous, 3	10.5	COL8A2 SLC4A11 VSX1 ZEB1
24	basal cell carcinoma	10.5	BAX BCL2 FASLG KRT20
25	malignant teratoma	10.4	BAX BCL2
26	gastric adenocarcinoma	10.4	BAX BCL2 FASLG KRT20
27	keratopathy	10.3
28	bullous keratopathy	10.3
29	corneal degeneration	10.3	TGFBI VSX1
30	cataract	10.3
31	keratoconus	10.1
32	corneal disease	10.1	AGBL1 COL8A2 SLC4A11 TGFBI VSX1 ZEB1
33	aging	9.9
34	blepharospasm	9.9

Graphical network of the top 20 diseases related to Fuchs' Endothelial Dystrophy:

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Symptoms & Phenotypes for Fuchs' Endothelial Dystrophy

MGI Mouse Phenotypes related to Fuchs' Endothelial Dystrophy:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	immune system	MP:0005387	9.65	AGBL1 BAX BCL2 CLU FASLG PITX2
2	vision/eye	MP:0005391	9.32	BAX BCL2 COL8A2 FASLG PITX2 SLC4A11

Sources

Drugs & Therapeutics for Fuchs' Endothelial Dystrophy

Drugs for Fuchs' Endothelial Dystrophy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Loteprednol

Approved

Phase 4

82034-46-6, 129260-79-3

444025 9865442

Synonyms:

17-Ethoxycarbonyloxy-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate, chloromethyl

82034-46-6

AC1L9FKJ

AKOS005145741

Alrex

Alrex, Lotemax, Loteprednol etabonate

CDDD-5604

CEHOAC

CHEBI:31784

CHEMBL1200865

chloromethyl (8S,9S,10R,11S,13S,14S,17R)-17-ethoxycarbonyloxy-11-hydroxy-10,13-dimethyl-3-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthrene-17-carboxylate

Chloromethyl 17 ethoxycarbonyloxy 11 hydroxy 3 oxoandrosta 1,4 diene 17 carboxylate

chloromethyl 17alpha-[(ethoxycarbonyl)oxy]-11beta-hydroxy-3-oxoandrosta-1,4-diene-17beta-carboxylate

Chloromethyl 17-ethoxycarbonyloxy-11-hydroxy-3-oxoandrosta-1,4-diene-17-carboxylate

CID444025

CPD000469178

D01689

DB00873

Etabonate, loteprednol

HGP-1

HMS2051F16

IDR-90102

IDR-90103

Locort

Loteflam

Lotemax

Lotemax (TN)

Loteprednol

Loteprednol etabonate

Loteprednol etabonate (JAN/USAN)

Loteprednolum

Loterox

MLS001424221

MolPort-003-848-424

NCGC00164594-01

P-5604

S1669_Selleck

SAM001246630

SMR000469178

ZINC03920673

Methylprednisolone

Approved, Vet_approved

Phase 4,Phase 2

83-43-2

6741

Synonyms:

(6a,11b)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione

(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione

(6S,8S,9S,10R,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-6,10,13-trimethyl-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-one

(6α,11β)-11,17,21-trihydroxy-6-methylpregna-1,4-diene-3,20-dione

.DELTA.1-6.alpha.-Methylhydrocortisone

11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione

11-beta,17,21-Trihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione

11beta,17alpha,21-Trihydroxy-6alpha-methyl-1,4-pregnadiene-3,20-dione

11beta,17alpha,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione

121673-01-6

1-dehydro-6alpha-Methylhydrocortisone

1-Dehydro-6alpha-methylhydrocortisone

1-dehydro-6a-Methylhydrocortisone

1-dehydro-6α-methylhydrocortisone

4-08-00-03498 (Beilstein Handbook Reference)

46436_FLUKA

46436_RIEDEL

570-35-4

6 Methylprednisolone

6.alpha.-Methylprednisolone

6923-42-8

6alpha-Methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione

6alpha-methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione

6alpha-Methyl-11beta,17alpha,21-triol-1,4-pregnadiene-3,20-dione

6alpha-Methylprednisolone

6-alpha-Methylprednisolone

6a-Methyl-11b,17a,21-triol-1,4-pregnadiene-3,20-dione

6-Methylprednisolone

6α-methyl-11β,17α,21-triol-1,4-pregnadiene-3,20-dione

83-43-2

AC1L1N7A

Artisone-wyeth

Artisone-Wyeth

Besonia

Bio-0658

BPBio1_000174

BRD-K35240538-001-03-1

BRN 2340300

BSPBio_000158

CHEBI:6888

CHEMBL650

CID6741

CPD000058330

D00407

D008775

DB00959

delta(1)-6alpha-Methylhydrocortisone

Delta(1)-6alpha-Methylhydrocortisone

delta(1)-6a-Methylhydrocortisone

delta(sup 1)-6-alpha-Methylhydrocortisone

Depo-Medrol (acetate)

Dopomedrol

EINECS 201-476-4

Esametone

Firmacort

HMS1568H20

HMS2090B13

HSDB 3127

Lemod

LMST02030178

LS-118498

M0639_SIGMA

M1665

Medesone

Medixon

Medlone 21

Medrate

Medric acid

Medrol

Medrol (TN)

Medrol adt pak

Medrol Adt Pak

Medrol dosepak

Medrol Dosepak

Medrol, Solu-Medrol, Medrone, Methylprednisolone

Medrone

MEPRDL

Mesopren

Metastab

Methyleneprednisolone

Methylprednisolon

methylprednisolone

Methylprednisolone

Methylprednisolone (JP15/USP/INN)

Methylprednisolone [USAN:INN:BAN:JAN]

Methylprednisolone, 6-alpha

Methylprednisolonum

Methylprednisolonum [INN-Latin]

methylprenisolone

Metilbetasone

Metilprednisolona

Metilprednisolona [INN-Spanish]

Metilprednisolone

Metilprednisolone [Dcit]

Metilprednisolone [DCIT]

Metipred

Metrisone

Metrocort

Metysolon

MLS000028541

MLS001148159

MLS002207191

Moderin

MolPort-002-528-554

NCGC00022735-03

NCI60_001657

Nirypan

Noretona

NSC19987

NSC-19987

Predni N Tablinen

Prednol- L

Pregna-1,4-diene-3,20-dione, 11beta,17,21-trihydroxy-6alpha-methyl- (8CI)

Prestwick_622

Prestwick0_000279

Prestwick1_000279

Prestwick2_000279

Prestwick3_000279

Promacortine

Reactenol

S1733_Selleck

SAM002589984

Sieropresol

SMR000058330

Solomet

SPBio_002377

Summicort

Suprametil

U 7532

UNII-X4W7ZR7023

Urbason

Urbasone

Wyacort

ZINC03875560

δ(1)-6a-methylhydrocortisone

δ(1)-6α-methylhydrocortisone

Prednisolone

Approved, Vet_approved

Phase 4,Phase 2

50-24-8

5755

Synonyms:

(11b)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione

(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione

(11β)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione

.DELTA.1-Cortisol

.DELTA.1-Dehydrocortisol

.DELTA.1-Dehydrohydrocortisone

.DELTA.1-Hydrocortisone

.delta.-Cortef

.delta.-Stab

1,2-Dehydrohydrocortisone

1,4-Pregnadiene-11b,17a,21-triol-3,20-dione

1,4-Pregnadiene-11beta,17alpha,21-triol-3,20-dione

1,4-Pregnadiene-11β,17α,21-triol-3,20-dione

1,4-Pregnadiene-3,20-dione-11b,17a,21-triol

1,4-Pregnadiene-3,20-dione-11beta,17alpha,21-triol

1,4-Pregnadiene-3,20-dione-11β,17α,21-triol

1-Dehydrocortisol

1-Dehydrohydrocortisone

3,20-dioxo-11b,17a,21-Trihydroxy-1,4-pregnadiene

3,20-dioxo-11beta,17alpha,21-Trihydroxy-1,4-pregnadiene

3,20-dioxo-11β,17α,21-trihydroxy-1,4-pregnadiene

46656_FLUKA

46656_RIEDEL

50-24-8

58201-11-9

8056-11-9

AC-1773

AC1L1L2E

Ak-Pred

Ak-Tate

Alphadrol

Articulose-50

Bio-0666

BPBio1_000164

BRD-K98039984-001-03-0

BRN 1354103

BSPBio_000148

Bubbli-Pred

C07369

CCRIS 980

CHEBI:8378

CHEMBL131

CID5755

Codelcortone

Co-Hydeltra

CO-Hydeltra

component of Ataraxoid

component of K-Predne-Dome

Cordrol

Cortalone

Cotogesic

Cotolone

CPD000718761

D00472

D011239

DB00860

Decaprednil

Decortin H

Delcortol

Delta F

delta(1)-Cortisol

delta(1)-Dehydrocortisol

Delta(1)-Dehydrocortisol

delta(1)-Dehydrohydrocortisone

Delta(1)-dehydrohydrocortisone

Delta(1)-Dehydrohydrocortisone

delta(1)-Hydrocortisone

Delta(1)-Hydrocortisone

delta(sup 1)-Cortisol

delta(sup 1)-Dehydrocortisol

delta(sup 1)-Dehydrohydrocortisone

delta(sup 1)-Hydrocortisone

Delta-Cortef

Delta-Cortef (TN)

Deltacortenol

Deltacortril

Deltacortril Enteric

delta-dehydrocortisol

delta-dehydrohydrocortisone

Delta-Ef-Cortelan

delta-hydrocortisone

Deltahydrocortisone

Deltasolone

Delta-stab

Delta-Stab

Deltisilone

Depo-Medrol

Derpo Pd

Derpo PD

Dexa-Cortidelt hostacortin H

Dexa-Cortidelt Hostacortin H

Di adreson F

Di Adreson F

Di-adreson F

Di-Adreson F

Di-adreson-F

DiAdresonF

Di-Adreson-F

Dicortol

Donisolone

Dydeltrone

Eazolin D

Econopred

Econopred Plus

EINECS 200-021-7

Erbacort

Erbasona

Estilsona

Fernisolone

Fernisolone P

Fernisolone-P

Flamasone

HMS1568H10

HMS2090J05

Hostacortin H

HSDB 3385

Hydeltra

Hydeltrasol

Hydeltra-Tba

Hydeltrone

Hydrodeltalone

Hydrodeltisone

Hydroretrocortin

Hydroretrocortine

Inflamase Forte

Inflamase Mild

I-Pred

K 1557

Key-Pred

Klismacort

Lentosone

Lite Pred

LMST02030179

LS-7669

Medrol

Medrol Acetate

Metacortandralone

Methylprednisolone acetate

Methylprednisolone Acetate

Meticortelone

Meti-Derm

Metreton

MLS001304083

MLS002154250

MLS002207037

MolPort-002-507-147

M-Predrol

NCGC00179649-01

Neo-Delta-Cortef

Nisolone

Nor-Pred T.B.A.

NSC 9120

NSC9120

NSC9900

Ocu-Pred

Ocu-Pred Forte

Ophtho-Tate

Orapred

P0152_SIGMA

P0637

P6004_SIGMA

Panafcortelone

Paracortol

Paracotol

Pediapred

Poly-Pred

PRDL

Precortalon

Precortancyl

Precortilon

Precortisyl

Pred Forte

Pred Mild

Predair

Predair A

Predair Forte

Predalone 50

Predalone T.B.A.

Predate

Predate Tba

Predate-50

Predcor-25

Predcor-50

Predcor-Tba

PRED-G

Predisolone sodium phosphate

Predisolone Sodium Phosphate

Predne-Dome

Prednelan

Prednicen

Predni-Dome

Predniliderm

Predniretard

Prednis

Prednisolona

Prednisolona [INN-Spanish]

prednisolone

Prednisolone (anhydrous)

Prednisolone (JP15/USP/INN)

Prednisolone [INN:BAN:JAN]

Prednisolone acetate

Prednisolone Acetate

Prednisolone sodium phosphate

Prednisolone Sodium Phosphate

Prednisolone tebutate

Prednisolone Tebutate

Prednisolonum

Prednisolonum [INN-Latin]

Predonin

Predonine

Prelone

Prenolone

Prestwick_404

Prestwick0_000274

Prestwick1_000274

Prestwick2_000274

Prestwick3_000274

Rolisone

S1737_Selleck

SAM002264639

Scherisolon

SMR000718761

Solone

SPBio_002367

Steran

Sterane

Sterolone

Supercortisol

Ulacort

Ultra Pred

Ultracorten H

Ultracortene H

Ultracortene-H

Ultracortene-hydrogen

Ultracortene-Hydrogen

UNII-9PHQ9Y1OLM

ZINC03833821

δ(1)-dehydrocortisol

δ(1)-dehydrohydrocortisone

δ(1)-hydrocortisone

Anti-Allergic Agents

Phase 4,Phase 2

Antiemetics

Phase 4,Phase 2

Anti-Inflammatory Agents

Phase 4,Phase 2

Antineoplastic Agents, Hormonal

Phase 4,Phase 2

Autonomic Agents

Phase 4,Phase 2

Gastrointestinal Agents

Phase 4,Phase 2

glucocorticoids

Phase 4,Phase 2

Hormone Antagonists

Phase 4,Phase 2

Hormones

Phase 4,Phase 2

Hormones, Hormone Substitutes, and Hormone Antagonists

Phase 4,Phase 2

Methylprednisolone acetate

Phase 4,Phase 2

Methylprednisolone Hemisuccinate

Phase 4,Phase 2

Neuroprotective Agents

Phase 4,Phase 2

Ophthalmic Solutions

Phase 4,Phase 3

Peripheral Nervous System Agents

Phase 4,Phase 2

Pharmaceutical Solutions

Phase 4,Phase 3,Phase 2

Prednisolone acetate

Phase 4,Phase 2

Prednisolone hemisuccinate

Phase 4,Phase 2

Prednisolone phosphate

Phase 4,Phase 2

Protective Agents

Phase 4,Phase 2

Tetrahydrozoline

Phase 3

Fluorometholone

Approved, Investigational

Phase 2

426-13-1

9878

Synonyms:

(1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one

(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

11beta,17alpha-Dihydroxy-9-fluoro-6-methyl-1,4-pregnadiene-3,20-dione

426-13-1

9-Fluoro-11,17-dihydroxy-6-methylpregna-1,4-diene-3,20-dione

9-fluoro-11b,17-Dihydroxy-6a-methylpregna-1,4-diene-3,20-dione

9-fluoro-11beta,17-Dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione

9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione

9-Fluoro-11-beta,17-dihydroxy-6-alpha-methylpregna-1,4-diene-3,20-dione

9-fluoro-11β,17-dihydroxy-6α-methylpregna-1,4-diene-3,20-dione

AC1L1U0Y

AC-3520

AI3-52813

Alcon brand OF fluorometholone

Alcon Brand of Fluorometholone

Allergan brand 1 OF fluorometholone

Allergan Brand 1 of Fluorometholone

Allergan brand 2 OF fluorometholone

Allergan Brand 2 of Fluorometholone

Allergan brand 3 OF fluorometholone

Allergan Brand 3 of Fluorometholone

BPBio1_001029

BRD-K64862097-001-03-9

BSPBio_000935

CHEMBL1200600

CID9878

component of Neo-Oxylone

Cortilet

Cortisdin

D005469

D01367

DB00324

Delmeson

Efflumidex

EINECS 207-041-5

F0414

F9381_SIGMA

Fluaton

Flucon

Flucon, isopto

Flucon, Isopto

Flumetholon

Fluor Op

Fluor OP

Fluormetholon

Fluormetholone

Fluormetholonum

fluoro Ophtal

Fluoro Ophtal

Fluoromethalone

Fluorometholon

fluorometholone

Fluorometholone

Fluorométholone

Fluorometholone (JP15/USP/INN)

Fluorometholone [INN:BAN:JAN]

Fluorometholonum

Fluorometholonum [INN-Latin]

Fluorometolona

Fluorometolona [INN-Spanish]

Fluorometolone

Fluorometolone [DCIT]

fluoro-Ophtal

Fluoro-Ophtal

Fluor-Op

Fluor-OP

Fluor-op (TN)

Fluoropos

FML

Fml (TN)

FML Forte

FML Liquifilm

FML S.O.P

FML-S Liquifilm

HMS1570O17

Isdin brand OF fluorometholone

Isdin Brand of Fluorometholone

isopto Flucon

Isopto Flucon

Loticort

LS-118455

MLS000069537

MLS001076157

MolPort-003-941-413

NCGC00021575-03

NCI60_002886

Neo-Oxylone

Novartis brand OF fluorometholone

Novartis Brand of Fluorometholone

NSC 33001

NSC33001

NSC-33001

Oxylone

Oxylone (TN)

Pharm allergan brand OF fluorometholone

Pharm Allergan Brand of Fluorometholone

Pharm-allergan brand OF fluorometholone

Pharm-Allergan Brand of Fluorometholone

Pharmascience brand OF fluorometholone

Pharmascience Brand of Fluorometholone

PMS Fluorometholone

PMS-Fluorometholone

Pregna-1,4-diene-3,20-dione, 9-fluoro-11.beta.,17

Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17-dihydroxy-6alpha-methyl- (8CI)

Prestwick_227

Prestwick0_000718

Prestwick1_000718

Prestwick2_000718

Prestwick3_000718

SMR000058598

SPBio_002856

Trilcin

U 8614

UNII-SV0CSG527L

Ursapharm brand OF fluorometholone

Ursapharm Brand of Fluorometholone

Ursnon

Winzer brand OF fluorometholone

Winzer Brand of Fluorometholone

ZINC03876158

Dexamethasone

Approved, Investigational, Vet_approved

Phase 2

50-02-2

5743

Synonyms:

(3H)-Dexamethasone

.delta.(sup 1)-9-.alpha.-Fluoro-16-.alpha.-methylcortisol

.gamma.corten

137098-19-2

16.alpha.-Methyl-9.alpha.-fluoro-1-dehydrocortisol

16.alpha.-Methyl-9.alpha.-fluoroprednisolone

16alpha -Methyl-9alpha -fluoro-1-dehydrocortisol

16alpha -Methyl-9alpha -fluoroprednisolone

16alpha-Methyl-9alpha-fluoro-1-dehydrocortisol

16-alpha-Methyl-9-alpha-fluoro-1-dehydrocortisol

16alpha-Methyl-9alpha-fluoro-delta(sup 1)-hydrocortisone

16-alpha-Methyl-9-alpha-fluoro-delta(sup 1)-hydrocortisone

16-alpha-Methyl-9-alpha-fluoro-delta1-hydrocortisone

16alpha-Methyl-9alpha-fluoroprednisolone

16-alpha-Methyl-9-alpha-fluoroprednisolone

16a-Methyl-9a-fluoro-1-dehydrocortisol

16α-methyl-9α-fluoro-1-dehydrocortisol

16α-Methyl-9α-fluoro-1-dehydrocortisol

1-Dehydro-16.alpha.-methyl-9.alpha.-fluorohydrocortisone

1-dehydro-16alpha -Methyl-9alpha -fluorohydrocortisone

1-dehydro-16alpha-Methyl-9alpha-fluorohydrocortisone

1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone

1-dehydro-16a-Methyl-9a-fluorohydrocortisone

1-dehydro-16α-methyl-9α-fluorohydrocortisone

1-Dehydro-16α-methyl-9α-fluorohydrocortisone

23495-06-9

31375_FLUKA

46165_FLUKA

46165_RIEDEL

50-02-2

8054-59-9

9.alpha.-Fluoro-16.alpha.-methylprednisolone

906422-84-2

9a-fluoro-16a-Methylprednisolone

9a-fluoro-16BETA-METHYLPREDNISOLONE

9A-FLUORO-16BETA-METHYLPREDNISOLONE

9alpha -fluoro-16alpha -Methylprednisolone

9alpha-fluoro-16alpha-Methylprednisolone

9alpha-fluoro-16alpha-Methyl-prednisolone

9-alpha-fluoro-16-alpha-Methylprednisolone

9alpha-Fluoro-16alpha-methylprednisolone

9-alpha-Fluoro-16-alpha-methylprednisolone

9-fluoro-11,17,21-Trihydroxy-16-methylpregna-1,4-diene-3,20-dione

9-fluoro-11alpha -Methylpregna-1,4-diene-3,20-dione

9-fluoro-16-Methylprednisolone

9α-fluoro-16α-methylprednisolone

9α-Fluoro-16α-methylprednisolone

AC-11056

AC1L1L1H

AC1Q29DM

Adexone

Aeroseb-D

Aeroseb-dex

Aeroseb-Dex

AI3-50934

Ak dex OPH otic soln 0.1%

Alcon brand OF dexamethasone

Alcon Brand of Dexamethasone

alpha -fluoro-16-alpha -Methylcortisol

Anaflogistico

Aphtasolon

Aphthasolone

apo-Dexamethasone

Auxiron

Azimycin (veterinary)

Azium

Azium (veterinary)

Azium (Veterinary)

BIDD:ER0494

BIDD:PXR0060

Bisu Ds

Bisu DS

BRD-K38775274-001-02-3

BRD-K38775274-001-06-4

BSPBio_000995

C15643

C22H29FO5

Calonat

CCRIS 7067

CHEBI:41879

CHEMBL384467

CID5743

Corson

Corsone

Cortisumman

CPD001227192

CPD-10549

D00292

D003907

D1756_SIGMA

D4902_SIGMA

D6645_SIGMA

D8893_SIGMA

D9184_SIGMA

DB01234

Decacort

Decacortin

Decaderm

Decadron

Decadron (TN)

Decadron Tablets, Elixir

Decadron, Dexamethasone

Decadron-La

Decadron-LA

Decagel

Decaject

Decaject l.a.

Decaject L.A.

Decaject-l.a.

Decaject-L.A.

Decalix

Decameth

Decasone

Decaspray

Dectancyl

Dekacort

delta(sup 1)-9-alpha-Fluoro-16-alpha-methylcortisol

delta1-9alpha-Fluoro-16alpha-methylcortisol

Delta1-9alpha-fluoro-16alpha-Methylcortisol

Deltafluorene

Dergramin

Deronil

Desadrene

Desametasone

Desametasone [Dcit]

Desametasone [DCIT]

Desamethasone

Desameton

Deseronil

DEX

Dexa

DEXA

Dexa mamallet

Dexa Mamallet

Dexacen-4

Dexacidin

Dexacort

Dexacortal

Dexa-cortidelt

Dexa-Cortidelt

Dexacortin

Dexa-cortisyl

Dexa-Cortisyl

Dexadeltone

Dexafarma

Dexair

Dexalona

Dexaltin

Dexa-Mamallet

Dexametasona

Dexametasona [INN-Spanish]

Dexametasone

Dexameth

Dexamethansone

dexamethasone

Dexamethasone

Dexamethasone (JP15/USP/INN)

Dexamethasone [INN:BAN:JAN]

Dexamethasone acetate

Dexamethasone Acetate

Dexamethasone alcohol

Dexamethasone Alcohol

Dexamethasone base

Dexamethasone Base

Dexamethasone intensol

Dexamethasone Intensol

Dexamethasone sodium phosphate

Dexamethasone Sodium Phosphate

Dexamethasone-omega

Dexamethasonum

Dexamethasonum [INN-Latin]

Dexamethazone

Dexamonozon

Dexapolcort

Dexapos

Dexaprol

Dexa-scheroson

Dexa-Scheroson

Dexa-sine

Dexa-Sine

Dexason

Dexasone

Dexasone 0.5MG

Dexasone 0.75MG

Dexasone 4MG

Dexasporin

Dex-ide

Dex-Ide

Dexinolon

Dexinoral

Dexone

Dexone 0.5

DEXONE 0.5

Dexone 0.75

DEXONE 0.75

Dexone 1.5

DEXONE 1.5

Dexone 4

DEXONE 4

Dexonium

Dexpak

Dextelan

Dezone

Dinormon

DXM

Dxms

DXMS

ECR brand OF dexamethasone

ECR Brand of Dexamethasone

EINECS 200-003-9

Fluormethylprednisolone

Fluormone

Fluorocort

Fortecortin

Foy brand OF dexamethasone

Foy Brand of Dexamethasone

FT-0080377

Gammacorten

Hexadecadrol

Hexadrol

Hexadrol elixir

Hexadrol Elixir

Hexadrol Tablets

Hl-dex

Hl-Dex

HL-Dex

HMS1792A17

HMS1990A17

HMS2089N13

HSDB 3053

I06-1196

ICN brand OF dexamethasone

ICN Brand of Dexamethasone

IontoDex

isopto-Dex

Isopto-Dex

Lokalison F

Loverine

LS-7300

Luxazone

Maxidex

Maxidex ont 0.1%

Maxidex sus 0.1%

Maxitrol

Mediamethasone

Merck brand OF dexamethasone

Merck Brand of Dexamethasone

Merz brand 1 OF dexamethasone

Merz Brand 1 of Dexamethasone

Merz brand 2 OF dexamethasone

Merz Brand 2 of Dexamethasone

Methylfluorprednisolone

Mexidex

Millicorten

MK 125

MLS001055412

MLS001332507

MLS001332508

MolMap_000018

MolPort-003-846-433

Mymethasone

Naquasone (veterinary)

NCGC00091019-01

NCGC00091019-02

NCGC00091019-03

NCGC00091019-04

NCGC00091019-05

nchembio809-comp2

NCI60_003067

Neomycin and polymyxin b sulfates and dexamethasone

Neomycin and polymyxin b sulphates and dexamethasone

NSC 34521

NSC34521

Ocu-trol

Ocu-Trol

Oradexon

OTO-104

Pet derm III

Pet Derm Iii

Pet Derm III

Pet-Derm Iii

PHL-Dexamethasone

PMS Dexamethasone elixir 0.5mg/5ML

PMS-Dexamethasone

Policort

Posurdex

Prednisolon F

Prednisolone F

Prodex

S1322_Selleck

SAM002548948

Sandoz dexamethasone

SGCUT00126

Sk-Dexamethasone

SK-Dexamethasone

SMP1_000092

SMR000857119

SMR001227192

Spectrum5_002019

Spoloven

ST50307091

Sunia sol D

Sunia Sol D

Superprednol

TL8003317

to_000038

Tobradex

Tobramycin and dexamethasone

Tresaderm (veterinary)

Turbinaire

UNII-7S5I7G3JQL

Visumetazone

WLN: L E5 B666 OV KU MUTJ A1 BF CQ E1 FV1Q FQ G1

ZINC03875332

BB 1101

Phase 2

Dexamethasone acetate

Phase 2

1177-87-3

HIV Protease Inhibitors

Phase 2

protease inhibitors

Phase 2

Hyaluronic acid

Approved, Vet_approved

9004-61-9

53477741

Adjuvants, Immunologic

Viscosupplements

Interventional clinical trials:

(show all 37)

#	Name	Status	NCT ID	Phase	Drugs
1	Fuchs' Torsional Phaco Study	Completed	NCT00781027	Phase 4
2	Comparison of Corticosteroid Dosing Regimens After Endothelial Keratoplasty	Completed	NCT01853696	Phase 4	loteprednol etabonate;prednisolone acetate 1%
3	Intrastromal Corneal Ring for High Astigmatism on Postkeratoplasty	Completed	NCT01018797	Phase 4
4	Glanatec(R) for Descemet Stripping in Fuch's Endothelial Dystrophy	Recruiting	NCT03249337	Phase 4	Ripasudil hydrochloride hydrate 0.4% ophthalmic solution
5	Trial of Netarsudil for Prevention of Corticosteroid-induced Intraocular Pressure Elevation	Recruiting	NCT03248037	Phase 3	Netarsudil;Placebo
6	Comparison of Two Steroid Regimens to Prevent Transplant Rejection After Corneal Transplant (DMEK)	Completed	NCT01448213	Phase 2	Prednisolone acetate;Fluorometholone
7	Ripasudil 0.4% Eye Drops in Fuchs Endothelial Corneal Dystrophy	Recruiting	NCT03575130	Phase 2	Ripasudil eye drops;Optive eye drops
8	Immunosuppression During Penetrating Keratoplasty, Using a Subconjunctival Implant Releasing Dexamethasone : Tolerance and Safety Pilot Study	Recruiting	NCT02834260	Phase 2	Dexamethasone implant OZURDEX
9	Comparing Endoglide to Endoserter for DSAEK Graft Insertion	Unknown status	NCT01791075	Not Applicable
10	Comparison of Corneal Grafts Cultured in Serum-free Versus Corneal Grafts Cultured in Serum Supplemented Culture Media	Unknown status	NCT00623584	Not Applicable
11	Cornea Donor Study	Unknown status	NCT00006411	Not Applicable
12	DSAEK- Postoperative Positioning and Transplant Dislocation	Unknown status	NCT01206127	Not Applicable
13	Outcome After Descemet Membrane Endothelial Keratoplasty (DMEK) and Ultra-thin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK)	Unknown status	NCT02020044	Not Applicable
14	Early Experience With Descemet's Stripping Automated Endothelial Keratoplasty	Unknown status	NCT00744796	Not Applicable
15	ODM 5 in the Treatment of Corneal Edematous Fuchs' Endothelial Dystrophy	Completed	NCT02332109
16	Fuchs' Endothelial Dystrophy: Clinical Characteristics, Treatment Outcome, and Pathology	Completed	NCT01979250	Not Applicable
17	The Molecular Pathogenesis of Late-onset Fuchs' Endothelial Corneal Dystrophy	Completed	NCT01795001
18	Comparison of Two Techniques in Achieving Corneal Graft	Completed	NCT01610973	Not Applicable
19	Combined Cataract Surgery and Planned Descemetorhexis	Completed	NCT02206594	Not Applicable
20	Long Term Cornea Graft Survival Study	Completed	NCT02849808
21	Study of Eye Bank Pre-cut Donor Grafts for Endothelial Keratoplasty	Completed	NCT00624221	Not Applicable
22	Impact of Cataract Surgery on Keratoplasty Graft Survival	Completed	NCT02875145
23	A Comparison Between Full Thickness and Partial Thickness Corneal Transplantation for Corneal Edema	Completed	NCT00346138	Not Applicable
24	PIONEER: Intraoperative and Perioperative OCT Study	Completed	NCT02423161
25	The German Keratoplasty Registry of the German Ophthalmological Society (DOG)	Completed	NCT03381794
26	Evaluation of the Efficacy of Descemet Membrane Transplantation for the Treatment of Fuchs' Endothelial Dystrophy	Recruiting	NCT03275896	Early Phase 1
27	Assessment of Corneal Graft Attachment in Patients With Fuchs Endothelial Corneal Dystrophy Following DMEK Using Ultra-high Resolution OCT	Recruiting	NCT02542644	Not Applicable
28	DMEK Versus DSAEK Study	Recruiting	NCT02793310	Not Applicable
29	Novel Diagnostics With Optical Coherence Tomography: Imaging the Anterior Eye	Recruiting	NCT00343473
30	Technique And Results In Endothelial Keratoplasty	Recruiting	NCT02470793	Not Applicable
31	Air Versus SF6 for Descemet's Membrane Endothelial Keratoplasty (DMEK)	Recruiting	NCT03407755	Not Applicable
32	Study of Endothelial Keratoplasty Outcomes	Recruiting	NCT00800111	Not Applicable
33	DISCOVER Study: Microscope-integrated Intraoperative OCT Study	Recruiting	NCT02423213
34	OCT-guided DSAEK Graft Shaping and Smoothing	Terminated	NCT01586234	Not Applicable
35	Using the Optovue OCT to Select IOL Power	Terminated	NCT01361282
36	Study of the Effect of Aspheric Lenses in Patients With Fuch's Dystrophy	Withdrawn	NCT02109276	Not Applicable
37	Specular Microscopy Study	Withdrawn	NCT02478970	Not Applicable

Search NIH Clinical Center for Fuchs' Endothelial Dystrophy

Cochrane evidence based reviews: fuchs' endothelial dystrophy

Sources

Genetic Tests for Fuchs' Endothelial Dystrophy

Genetic tests related to Fuchs' Endothelial Dystrophy:

#	Genetic test	Affiliating Genes
1	Fuchs Endothelial Corneal Dystrophy ²⁹

Sources

Anatomical Context for Fuchs' Endothelial Dystrophy

MalaCards organs/tissues related to Fuchs' Endothelial Dystrophy:

⁴¹

Endothelial, Eye

Sources

Publications for Fuchs' Endothelial Dystrophy

Articles related to Fuchs' Endothelial Dystrophy:

(show top 50) (show all 185)

#	Title	Authors	Year
1	Quarter-Descemet membrane endothelial keratoplasty (Quarter-DMEK) for Fuchs endothelial corneal dystrophy: 6 months clinical outcome. ( 29343529 )	Zygoura V....Melles G.R.J.	2018
2	Repeat-Associated Non-ATG (RAN) Translation in Fuchs' Endothelial Corneal Dystrophy. ( 29677349 )	Soragni E....Gottesfeld J.M.	2018
3	Analysis of candidate genes ZEB1 and LOXHD1 in late-onset Fuchs' endothelial corneal dystrophy in an Indian cohort. ( 29799290 )	Rao B.S....Soumittra N.	2018
4	Gene Editing as a Potential Therapeutic Solution for Fuchs Endothelial Corneal Dystrophy: The Future Is Clearer. ( 29931030 )	Zhu A.Y....Jun A.S.	2018
5	Primary Descemet's Membrane Endothelial Keratoplasty for Fuchs Endothelial Dystrophy versus Bullous Keratopathy: Histopathology and Clinical Results. ( 29939775 )	Brockmann T....Torun N.	2018
6	Function-Related Protein Expression in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Models. ( 29698634 )	ThAcriault M....Proulx S.	2018
7	Outcomes of conventional phacoemulsification versus femtosecond laser-assisted cataract surgery in eyes with Fuchs endothelial corneal dystrophy. ( 29773458 )	Zhu D.C....Koo E.H.	2018
8	Gene expression in the corneal endothelium of Fuchs endothelial corneal dystrophy patients with and without expansion of a trinucleotide repeat in TCF4. ( 29966009 )	Wieben E.D....Fautsch M.P.	2018
9	Corneal Optical Changes Associated with Induced Edema in Fuchs Endothelial Corneal Dystrophy. ( 29408827 )	Wacker K....Patel S.V.	2018
10	Hyperopic Trend after Cataract Surgery in Eyes with Fuchs' Endothelial Corneal Dystrophy. ( 29716785 )	Wacker K....Patel S.V.	2018
11	Pathological molecular mechanism of symptomatic late-onset Fuchs endothelial corneal dystrophy by bioinformatic analysis. ( 29787599 )	Cui Z....Chen J.	2018
12	Medical and Semi-surgical Treatments for Fuchs Endothelial Corneal Dystrophy. ( 29723889 )	Wacker K....Patel S.V.	2018
13	Association of the Gutta-Induced Microenvironment With Corneal Endothelial Cell Behavior and Demise in Fuchs Endothelial Corneal Dystrophy. ( 29852040 )	Kocaba V....Jurkunas U.V.	2018
14	Evolving therapies for Fuchs' endothelial dystrophy. ( 29360003 )	Soh Y.Q....Mehta J.S.	2018
15	Feasibility of cell-based therapy combined with descemetorhexis for treating Fuchs endothelial corneal dystrophy in rabbit model. ( 29338061 )	Okumura N....Koizumi N.	2018
16	Regenerative Therapy for Fuchs Endothelial Corneal Dystrophy. ( 29384808 )	Soh Y.Q....Mehta J.S.	2018
17	Femtosecond laser-assisted cataract surgery in Fuchs' endothelial corneal dystrophy: Long-term outcomes. ( 29958766 )	Fan W....Zhang G.	2018
18	Fuchs endothelial corneal dystrophy and macular drusen: evidence for coincidence? ( 29350686 )	Matthaei M....Heindl L.M.	2018
19	NQO1 downregulation potentiates menadione-induced endothelial-mesenchymal transition during rosette formation in Fuchs endothelial corneal dystrophy. ( 29294389 )	Katikireddy K.R....Jurkunas U.V.	2018
20	DMEK versus DSAEK for Fuchs' endothelial dystrophy: A meta-analysis. ( 29661044 )	Marques R.E....Rodrigues W.	2018
21	Factors Influencing Visual Acuity in Fuchs' Endothelial Corneal Dystrophy. ( 29252902 )	Kobashi H....Shimizu K.	2018
22	Trinucleotide Repeat Expansion in the Transcription Factor 4 (TCF4) Gene Leads to Widespread mRNA Splicing Changes in Fuchs' Endothelial Corneal Dystrophy. ( 28118661 )	Wieben E.D....Fautsch M.P.	2017
23	Corneal Backscatters as an Objective Index for Assessing Fuchs' Endothelial Corneal Dystrophy: A Pilot Study. ( 28751984 )	Chu H.Y....Tan H.Y.	2017
24	Peripheral Endothelial Cell Count Is a Predictor of Disease Severity in Advanced Fuchs Endothelial Corneal Dystrophy. ( 28731879 )	Syed Z.A....Jurkunas U.V.	2017
25	Association of polymorphisms in the intron of TCF4 gene to late-onset Fuchs endothelial corneal dystrophy: An Indian cohort study. ( 29044056 )	Rao B.S....Soumittra N.	2017
26	Fuchs' Endothelial Corneal Dystrophy and RNA Foci in Patients With Myotonic Dystrophy. ( 28886202 )	Mootha V.V....Gong X.	2017
27	Study of light scattering using C-Quant(Ar) in patients with Fuchs' endothelial dystrophy: A pilot study. ( 28320557 )	CastaA+o-MartA-n B....Teus M.	2017
28	Sustained Activation of the Unfolded Protein Response Induces Cell Death in Fuchs' Endothelial Corneal Dystrophy. ( 28727885 )	Okumura N....Koizumi N.	2017
29	Activation of mitophagy leads to decline in Mfn2 and loss of mitochondrial mass in Fuchs endothelial corneal dystrophy. ( 28751712 )	Benischke A.S....Jurkunas U.V.	2017
30	Extracellular Matrix and Integrin Expression Profiles in Fuchs Endothelial Corneal Dystrophy Cells and Tissue Model. ( 28726551 )	Goyer B....Proulx S.	2017
31	Mini descemet membrane stripping (m-DMES) in patients with Fuchs' endothelial dystrophy: A new method. ( 29234234 )	Kymionis G.D....Petrelli M.K.	2017
32	Activation of TGF-I^ signaling induces cell death via the unfolded protein response in Fuchs endothelial corneal dystrophy. ( 28754918 )	Okumura N....Koizumi N.	2017
33	TGC repeat expansion in the TCF4 gene increases the risk of Fuchs' endothelial corneal dystrophy in Australian cases. ( 28832669 )	Kuot A....Sharma S.	2017
34	Author Response: Transforming Growth Factor Beta Switch in Aqueous Humor of Patients With Fuchs' Endothelial Corneal Dystrophy. ( 26927571 )	Matthaei M....Heindl L.M.	2016
35	Changes in Corneal Densitometry in Patients with Fuchs Endothelial Dystrophy after Endothelial Keratoplasty. ( 27260144 )	Alnawaiseh M....Zumhagen L.	2016
36	Fuchs Endothelial Corneal Dystrophy: A Systematic Immunofluorescence Study of Collagen Type VIII Suggests Heterogeneous Pathophysiology. ( 27078008 )	Nielsen E....Hjortdal J.	2016
37	Coenzyme Q10 in the Treatment of Corneal Edema in Kearns-Sayre: Is There an Application in Fuchs Endothelial Corneal Dystrophy? ( 27442316 )	Kim J....Nischal K.K.	2016
38	Preliminary outcome of hemi-Descemet membrane endothelial keratoplasty for Fuchs endothelial dystrophy. ( 26837507 )	Gerber-Hollbach N....Melles G.R.	2016
39	Treatment of Fuchs Endothelial Dystrophy by Descemet Stripping Without Endothelial Keratoplasty. ( 27310885 )	Borkar D.S....Colby K.A.	2016
40	The Ultrastructures and Mechanical Properties of the Descement's Membrane in Fuchs Endothelial Corneal Dystrophy. ( 26980551 )	Xia D....Dong M.	2016
41	[TGC Repeats in Intron 2 of the TCF4 Gene have a Good Predictive Power Regarding to Fuchs Endothelial Corneal Dystrophy]. ( 26280645 )	Luther M....Foja S.	2016
42	Descemet Stripping Automated Endothelial Keratoplasty in Fuchs' Endothelial Dystrophy versus Pseudophakic Bullous Keratopathy. ( 27994806 )	Javadi M.A....Ownagh V.	2016
43	Changes in Corneal Refractive Power for Patients With Fuchs Endothelial Dystrophy After DMEK. ( 27055217 )	Alnawaiseh M....Zumhagen L.	2016
44	Case Report of Quarter-Descemet Membrane Endothelial Keratoplasty for Fuchs Endothelial Dystrophy. ( 27583798 )	MA1ller T.M....Melles G.R.	2016
45	Evaluation of Endothelial Pump Function in Fuchs Endothelial Dystrophy Before and After Endothelial Keratoplasty. ( 27055221 )	Nielsen E....Hjortdal J.	2016
46	Corneal Densitometry, Central Corneal Thickness, and Corneal Central-to-Peripheral Thickness Ratio in Patients With Fuchs Endothelial Dystrophy. ( 26655484 )	Alnawaiseh M....Rosentreter A.	2016
47	Menadione-Induced DNA Damage Leads to Mitochondrial Dysfunction and Fragmentation During Rosette Formation in Fuchs Endothelial Corneal Dystrophy. ( 26935406 )	Halilovic A....Jurkunas U.V.	2016
48	Evaluation of Visual Quality in Patients With Fuchs Endothelial Corneal Dystrophy. ( 27631348 )	Oie Y....Nishida K.	2016
49	In Vivo Imaging of Corneal Endothelial Dystrophy in Boston Terriers: A Spontaneous, Canine Model for Fuchs' Endothelial Corneal Dystrophy. ( 27454658 )	Thomasy S.M....Murphy C.J.	2016
50	Existence of Neural Crest-Derived Progenitor Cells in Normal and Fuchs Endothelial Dystrophy Corneal Endothelium. ( 27639969 )	Katikireddy K.R....Jurkunas U.V.	2016

Sources

Genes for Fuchs' Endothelial Dystrophy

Genes related to Fuchs' Endothelial Dystrophy (8 elite genes):

(show all 33)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	COL8A2	Collagen Type VIII Alpha 2 Chain	Protein Coding	398.55	Causative germline mutation ⁵⁹ DISEASES inferred ¹⁵ Novoseek inferred ⁵⁵ GeneCards inferred via : Publications (show sections)	15175909 20144242 18502986 (more) 18024822 16936088
2	TCF4	Transcription Factor 4	Protein Coding	374.26	Causative germline mutation ⁵⁹ DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	SLC4A11	Solute Carrier Family 4 Member 11	Protein Coding	368.58	Causative germline mutation ⁵⁹ DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	AGBL1	ATP/GTP Binding Protein Like 1	Protein Coding	366.9	Causative germline mutation ⁵⁹ DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	ZEB1	Zinc Finger E-Box Binding Homeobox 1	Protein Coding	356.45	Causative germline mutation (loss of function) ⁵⁹ DISEASES inferred ¹⁵
6	FECD7	Corneal Dystrophy, Fuchs Endothelial, 7	Genetic Locus	50	MalaCards inferred ⁵⁷
7	FECD5	Corneal Dystrophy, Fuchs Endothelial, 5	Genetic Locus	50	MalaCards inferred ⁵⁷
8	FECD2	Corneal Dystrophy, Fuchs Endothelial 2	Genetic Locus	50	MalaCards inferred ⁵⁷
9	CLU	Clusterin	Protein Coding	22.48	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
10	TGFBI	Transforming Growth Factor Beta Induced	Protein Coding	22.4	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
11	VSX1	Visual System Homeobox 1	Protein Coding	22.2	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
12	PITX2	Paired Like Homeodomain 2	Protein Coding	21.26	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
13	LOXHD1	Lipoxygenase Homology Domains 1	Protein Coding	17.6	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
14	KRT20	Keratin 20	Protein Coding	17.11	GeneCards inferred via : Publications (show sections)
15	MUC1	Mucin 1, Cell Surface Associated	Protein Coding	17.11	GeneCards inferred via : Publications (show sections)
16	BAX	BCL2 Associated X, Apoptosis Regulator	Protein Coding	17.11	GeneCards inferred via : Publications (show sections)
17	PRDX2	Peroxiredoxin 2	Protein Coding	17.11	GeneCards inferred via : Publications (show sections)
18	BCL2	BCL2, Apoptosis Regulator	Protein Coding	17.11	GeneCards inferred via : Publications (show sections)
19	FASLG	Fas Ligand	Protein Coding	17.11	GeneCards inferred via : Publications (show sections)
20	PRDX5	Peroxiredoxin 5	Protein Coding	11.05	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
21	TM9SF1	Transmembrane 9 Superfamily Member 1	Protein Coding	11.01	DISEASES inferred ¹⁵ ¹⁵
22	PRDX3	Peroxiredoxin 3	Protein Coding	7.11	GeneCards inferred via : Publications (show sections)
23	PRDX6	Peroxiredoxin 6	Protein Coding	7.11	GeneCards inferred via : Publications (show sections)
24	COL8A1	Collagen Type VIII Alpha 1 Chain	Protein Coding	6.65	DISEASES inferred ¹⁵
25	AQP1	Aquaporin 1 (Colton Blood Group)	Protein Coding	6.58	Novoseek inferred ⁵⁵	15385580
26	LINC00970	Long Intergenic Non-Protein Coding RNA 970	RNA Gene	6.44	DISEASES inferred ¹⁵
27	KANK4	KN Motif And Ankyrin Repeat Domains 4	Protein Coding	6.3	DISEASES inferred ¹⁵
28	FBXO7	F-Box Protein 7	Protein Coding	6.05	DISEASES inferred ¹⁵
29	FNDC4	Fibronectin Type III Domain Containing 4	Protein Coding	5.77	DISEASES inferred ¹⁵
30	PTPRG	Protein Tyrosine Phosphatase, Receptor Type G	Protein Coding	5.75	DISEASES inferred ¹⁵
31	LAMC1	Laminin Subunit Gamma 1	Protein Coding	5.66	DISEASES inferred ¹⁵
32	MBNL2	Muscleblind Like Splicing Regulator 2	Protein Coding	5.54	DISEASES inferred ¹⁵
33	ATP1B1	ATPase Na+/K+ Transporting Subunit Beta 1	Protein Coding	5.41	DISEASES inferred ¹⁵

Sources

Variations for Fuchs' Endothelial Dystrophy

Sources

Expression for Fuchs' Endothelial Dystrophy

Search GEO for disease gene expression data for Fuchs' Endothelial Dystrophy.

Sources

Pathways for Fuchs' Endothelial Dystrophy

Pathways related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	DNA Damage Response (only ATM dependent) ¹	11.6	BAX BCL2 FASLG
2	Nanomaterial induced apoptosis ¹ Show member pathways Activation and oligomerization of BAK protein ⁶⁶ Apoptosis - multiple species ³⁷ Apoptosis Modulation by HSP70 ¹ Apoptotic factor-mediated response ⁶⁶ Release of apoptotic factors from the mitochondria ⁶⁶	11.42	BAX BCL2 FASLG
3	Platinum drug resistance ³⁷	11.2	BAX BCL2 FASLG
4	Interleukin-4 and 13 signaling ⁶⁶	10.98	BCL2 FASLG MUC1 ZEB1
5	Photodynamic therapy-induced AP-1 survival signaling. ¹	10.84	BAX BCL2 FASLG
6	Overview of nanoparticle effects ¹	10.68	BAX BCL2
7	Vinka Alkaloid Pathway, Pharmacokinetics ⁶¹	10.26	BAX BCL2

Sources

GO Terms for Fuchs' Endothelial Dystrophy

Cellular components related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	pore complex	GO:0046930	8.62	BAX BCL2

Biological processes related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	apoptotic process	GO:0006915	9.88	BAX BCL2 CLU FASLG KRT20 PRDX5
2	regulation of apoptotic process	GO:0042981	9.86	BAX BCL2 CLU PRDX2
3	cytokine-mediated signaling pathway	GO:0019221	9.84	BCL2 FASLG MUC1 ZEB1
4	male gonad development	GO:0008584	9.7	BAX BCL2 PITX2
5	cellular oxidant detoxification	GO:0098869	9.65	LOXHD1 PRDX2 PRDX5
6	hydrogen peroxide catabolic process	GO:0042744	9.55	PRDX2 PRDX5
7	endoplasmic reticulum calcium ion homeostasis	GO:0032469	9.51	BAX BCL2
8	extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	9.5	BAX BCL2 FASLG
9	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	GO:0097296	9.49	BAX FASLG
10	regulation of protein heterodimerization activity	GO:0043497	9.46	BAX BCL2
11	regulation of protein homodimerization activity	GO:0043496	9.43	BAX BCL2
12	leukocyte homeostasis	GO:0001776	9.37	BAX BCL2
13	regulation of nitrogen utilization	GO:0006808	9.26	BAX BCL2
14	positive regulation of developmental pigmentation	GO:0048087	9.16	BAX BCL2
15	retinal cell programmed cell death	GO:0046666	8.96	BAX FASLG
16	release of cytochrome c from mitochondria	GO:0001836	8.8	BAX BCL2 CLU

Molecular functions related to Fuchs' Endothelial Dystrophy according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	peroxiredoxin activity	GO:0051920	9.16	PRDX2 PRDX5
2	BH3 domain binding	GO:0051434	8.96	BAX BCL2
3	thioredoxin peroxidase activity	GO:0008379	8.62	PRDX2 PRDX5

Sources

Sources for Fuchs' Endothelial Dystrophy

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia