FHI
MCID: FCH002
MIFTS: 30

Fuchs' Heterochromic Uveitis (FHI)

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Fuchs' Heterochromic Uveitis

MalaCards integrated aliases for Fuchs' Heterochromic Uveitis:

Name: Fuchs' Heterochromic Uveitis 12 15
Fuchs Heterochromic Iridocyclitis 53 59
Fuchs' Heterochromic Cyclitis 12 73
Fuchs Heterochromic Cyclitis 53 55
Fhi 53 59
Fuch's Heterochromic Iridocyclitis 12
Fuchs Heterochromic Uveitis 53
Fuchs Uveitis Syndrome 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:9375
ICD10 33 H20.81
ICD9CM 35 364.21
SNOMED-CT 68 11226001
Orphanet 59 ORPHA263479
ICD10 via Orphanet 34 H20.8
UMLS via Orphanet 74 C0016782
UMLS 73 C0016782

Summaries for Fuchs' Heterochromic Uveitis

NIH Rare Diseases : 53 Fuchs heterochromic iridocyclitis (FHI) is an unusual form of chronic (long-lasting) uveitis. Uveitis is swelling and irritation of the middle layer of the eye. Diagnosis of FHI is considered in people with floaters, vision loss, and heterochromia. FHI often affects young adults and most often involves a single eye. People with FHI are at risk for cataract, glaucoma, and vitreous opacity (clouding of the jelly-like substance in the eyeball).  The cause of FHI is not known. Click here to view a diagram of the eye.

MalaCards based summary : Fuchs' Heterochromic Uveitis, also known as fuchs heterochromic iridocyclitis, is related to iridocyclitis and uveitis. An important gene associated with Fuchs' Heterochromic Uveitis is TGFB2 (Transforming Growth Factor Beta 2). The drugs Mycophenolic acid and Infliximab have been mentioned in the context of this disorder. Affiliated tissues include eye.

Disease Ontology : 12 A syndrome that is a chronic unilateral (or rarely bilateral) iridocyclitis appearing with the triad of heterochromia, predisposition to cataracts and glaucoma, and keratitic percipitates on the posterior corneal surface.

Related Diseases for Fuchs' Heterochromic Uveitis

Diseases related to Fuchs' Heterochromic Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 33)
# Related Disease Score Top Affiliating Genes
1 iridocyclitis 31.7 CYP11B1 MRAP
2 uveitis 31.3 IL2RA TGFB2
3 glaucomatocyclitic crisis 30.3 CYP11B1 MRAP
4 hyperinsulinemic hypoglycemia, familial, 2 11.1
5 retinal vasculitis 11.1
6 cataract 10.6
7 toxoplasmosis 10.6
8 ocular toxoplasmosis 10.6
9 retinitis pigmentosa 10.5
10 leber congenital amaurosis 4 10.5
11 retinitis 10.5
12 astigmatism 10.4
13 chikungunya 10.4
14 retinitis pigmentosa-deafness syndrome 10.4
15 usher syndrome 10.4
16 hemifacial atrophy, progressive 10.3
17 subclavian steal syndrome 10.3
18 facial hemiatrophy 10.3
19 chorioretinitis 10.3
20 toxocariasis 10.3
21 anterior uveitis 10.3
22 degos 'en cocarde' erythrokeratoderma 10.3
23 idiopathic anterior uveitis 10.3
24 keratoconus 10.3
25 niemann-pick disease 10.3
26 ophthalmomyiasis 10.3
27 herpes simplex 10.3
28 coats disease 10.2
29 horner's syndrome 10.2
30 rubella 10.2
31 panuveitis 9.9 CYP11B1 MRAP
32 cervicitis 9.8 IL2RA MRAP
33 behcet syndrome 9.7 IL2RA MRAP

Graphical network of the top 20 diseases related to Fuchs' Heterochromic Uveitis:



Diseases related to Fuchs' Heterochromic Uveitis

Symptoms & Phenotypes for Fuchs' Heterochromic Uveitis

Drugs & Therapeutics for Fuchs' Heterochromic Uveitis

Drugs for Fuchs' Heterochromic Uveitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mycophenolic acid Approved 24280-93-1 446541
2
Infliximab Approved 170277-31-3
3
Methotrexate Approved 59-05-2, 1959-05-2 126941
4
Prednisolone Approved, Vet_approved 50-24-8 5755
5
Azathioprine Approved 446-86-6 2265
6
rituximab Approved 174722-31-7 10201696
7
Etanercept Approved, Investigational 185243-69-0
8
Methylprednisolone Approved, Vet_approved 83-43-2 6741
9
Adalimumab Approved 331731-18-1 16219006
10
Methylprednisolone hemisuccinate Approved 2921-57-5
11
Prednisolone phosphate Approved, Vet_approved 302-25-0
12
Prednisolone hemisuccinate Experimental 2920-86-7
13 Prednisolone acetate
14 Methylprednisolone acetate
15 Antitubercular Agents
16 Antibiotics, Antitubercular
17 Antirheumatic Agents
18 Antimetabolites
19 Anti-Bacterial Agents
20 Immunologic Factors
21 Cyclosporins
22 Anti-Infective Agents
23 Antimetabolites, Antineoplastic
24 Immunosuppressive Agents
25 Anti-Inflammatory Agents Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Causes of Visual Loss in Retinal Disease Unknown status NCT01613963 Immunosuppressive Agents
2 Evaluation of Biological Biomarkers Diagnostic of Toxoplasmosis Uveitis Completed NCT02843438 Not Applicable Anti-toxoplasmosis treatment;Anti-inflammatory treatments

Search NIH Clinical Center for Fuchs' Heterochromic Uveitis

Genetic Tests for Fuchs' Heterochromic Uveitis

Anatomical Context for Fuchs' Heterochromic Uveitis

MalaCards organs/tissues related to Fuchs' Heterochromic Uveitis:

41
Eye

Publications for Fuchs' Heterochromic Uveitis

Articles related to Fuchs' Heterochromic Uveitis:

(show top 50) (show all 87)
# Title Authors Year
1
Fuchs heterochromic iridocyclitis-associated glaucoma: a retrospective comparison of primary Ahmed glaucoma valve implantation and trabeculectomy with mitomycin C. ( 30410728 )
2018
2
Moth-eaten appearance of the iris in Fuchs heterochromic iridocyclitis. ( 30447956 )
2018
3
Niemann-Pick Disease Type C Associated with Fuchs Heterochromic Iridocyclitis. ( 29387679 )
2017
4
Phacoemulsification and Core Vitrectomy in Fuchs' Heterochromic Uveitis. ( 28638250 )
2017
5
The unusual association of inverse retinitis pigmentosa and Fuchs' heterochromic iridocyclitis. ( 28127443 )
2017
6
Iris autofluorescence in Fuchs' heterochromic uveitis. ( 26758535 )
2016
7
Risk Factors for Glaucoma in a Cohort of Patients with Fuchs Heterochromic Iridocyclitis. ( 27494676 )
2016
8
Phacoemulsification Versus Manual Small Incision Cataract Surgery in Patients With Fuchs Heterochromic Iridocyclitis. ( 26939115 )
2016
9
Fuchs' Heterochromic Iridocyclitis in an Italian Tertiary Referral Centre: Epidemiology, Clinical Features, and Prognosis. ( 27781126 )
2016
10
Implantation of iris-claw Artisan intraocular lens for aphakia in Fuchs' heterochromic iridocyclitis. ( 23571252 )
2014
11
Associations of Fuchs heterochromic iridocyclitis in a South Indian patient population. ( 23514352 )
2013
12
Polymorphisms of TNFAIP3 Gene in a Chinese Han Population with Fuchs Heterochromic Iridocyclitis. ( 23463983 )
2013
13
Surgical management of secondary glaucoma in Fuchs' heterochromic iridocyclitis. ( 23519886 )
2013
14
Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. ( 22218256 )
2012
15
High concordance of intraocular antibody synthesis against the rubella virus and Fuchs heterochromic uveitis syndrome in Slovenia. ( 23233792 )
2012
16
Fuchs heterochromic iridocyclitis and the rubella virus. ( 21897135 )
2011
17
Corneal astigmatism in unilateral Fuchs heterochromic iridocyclitis. ( 21595529 )
2011
18
Fuchs' heterochromic iridocyclitis associated with ocular toxocariasis. ( 21331701 )
2011
19
Usher syndrome associated with Fuchs' heterochromic uveitis: a case report. ( 21607024 )
2011
20
Rubella virus as a possible etiological agent of Fuchs heterochromic iridocyclitis. ( 20585798 )
2010
21
Expression Profile of Intravitreous Cytokines, Chemokines and Growth Factors in Patients with Fuchs Heterochromic Iridocyclitis. ( 20737053 )
2010
22
Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. ( 20952847 )
2010
23
Usher syndrome associated with Fuchs' heterochromic uveitis. ( 20574746 )
2010
24
Confocal scan features of keratic precipitates in Fuchs heterochromic iridocyclitis. ( 19907293 )
2010
25
Fuchs heterochromic iridocyclitis--syndrome, disease, or both? ( 19782794 )
2009
26
Presumed Fuchs heterochromic iridocyclitis and Posner-Schlossman syndrome: comparison of cytomegalovirus-positive and -negative eyes. ( 19463548 )
2009
27
Presumed fuchs heterochromic iridocyclitis and Posner-Schlossman syndrome: comparison of cytomegalovirus-positive and negative eyes. ( 19027423 )
2008
28
Idiopathic no more: clues to the pathogenesis of Fuchs heterochromic iridocyclitis and glaucomatocyclitic crisis. ( 18435976 )
2008
29
Fuchs' heterochromic uveitis: a longitudinal clinical study. ( 17986291 )
2008
30
Fuchs' heterochromic uveitis associated with retinal break or dialysis. ( 18204494 )
2008
31
Epidemiologic relationship between fuchs heterochromic iridocyclitis and the United States rubella vaccination program. ( 17631266 )
2007
32
Ophthalmomyiasis associated with Fuchs heterochromic iridocyclitis. ( 17031305 )
2006
33
Unusual presentation of Amsler's sign in Fuchs' heterochromic uveitis. ( 16931278 )
2006
34
Rubella virus is associated with fuchs heterochromic iridocyclitis. ( 16387009 )
2006
35
Quantification of blood-aqueous barrier breakdown after phacoemulsification in Fuchs' heterochromic uveitis. ( 15627823 )
2005
36
Outcomes of phacoemulsification and in-the-bag intraocular lens implantation in Fuchs' heterochromic iridocyclitis. ( 15975468 )
2005
37
Fuchs' heterochromic iridocyclitis following bilateral ocular toxoplasmosis. ( 15209468 )
2004
38
Retinitis pigmentosa associated with Fuchs' heterochromic uveitis. ( 12928695 )
2003
39
Concern about long-term results of IOL implantation in Fuchs' heterochromic uveitis. ( 12954279 )
2003
40
Secondary posterior chamber intraocular lens implantation in Fuchs' heterochromic uveitis. ( 12101462 )
2002
41
Phacoemulsification in patients with Fuchs' heterochromic uveitis. ( 12160806 )
2002
42
Fuchs' heterochromic iridocyclitis: clinical manifestations in dark-eyed Mexican patients. ( 12778348 )
2002
43
Keratoconus and Fuchs' heterochromic iridocyclitis: a coincidence or a defect during embryogenesis? ( 11284490 )
2001
44
Fuchs' heterochromic iridocyclitis: a review of 26 cases. ( 11815885 )
2001
45
Astigmatism associated with Fuchs' heterochromic iridocyclitis. ( 11333322 )
2001
46
Vitrectomy for vitreous opacification in Fuchs' heterochromic uveitis. ( 10845020 )
2000
47
Herpes simplex virus DNA identification from aqueous fluid in Fuchs heterochromic iridocyclitis. ( 10844066 )
2000
48
Retinitis pigmentosa associated with Fuchs' heterochromic uveitis. ( 10865317 )
2000
49
Pre-operative hyphaema in Fuchs' heterochromic uveitis. ( 10696328 )
1999
50
Cataract surgery in patients with Fuchs' heterochromic iridocyclitis. ( 10482478 )
1999

Variations for Fuchs' Heterochromic Uveitis

Expression for Fuchs' Heterochromic Uveitis

Search GEO for disease gene expression data for Fuchs' Heterochromic Uveitis.

Pathways for Fuchs' Heterochromic Uveitis

GO Terms for Fuchs' Heterochromic Uveitis

Biological processes related to Fuchs' Heterochromic Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neutrophil chemotaxis GO:0030593 9.16 CCL4L2 TGFB2
2 negative regulation of immune response GO:0050777 8.96 IL2RA TGFB2
3 immune response GO:0006955 8.92 CCL4L2 CYP11B1 IL2RA OPRK1

Sources for Fuchs' Heterochromic Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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