FHI
MCID: FCH002
MIFTS: 37

Fuchs' Heterochromic Uveitis (FHI)

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Fuchs' Heterochromic Uveitis

MalaCards integrated aliases for Fuchs' Heterochromic Uveitis:

Name: Fuchs' Heterochromic Uveitis 12 15
Fuchs Heterochromic Iridocyclitis 20 58
Fuchs' Heterochromic Cyclitis 12 70
Fuchs Heterochromic Cyclitis 20 54
Fhi 20 58
Fuch's Heterochromic Iridocyclitis 12
Fuchs Heterochromic Uveitis 20
Fuchs Uveitis Syndrome 12

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 58  
Rare eye diseases


External Ids:

Disease Ontology 12 DOID:9375
ICD9CM 34 364.21
SNOMED-CT 67 11226001
ICD10 32 H20.81
ICD10 via Orphanet 33 H20.8
UMLS via Orphanet 71 C0016782
Orphanet 58 ORPHA263479
UMLS 70 C0016782

Summaries for Fuchs' Heterochromic Uveitis

GARD : 20 Fuchs heterochromic iridocyclitis (FHI) is an unusual form of chronic (long-lasting) uveitis. Uveitis is swelling and irritation of the middle layer of the eye. Diagnosis of FHI is considered in people with floaters, vision loss, and heterochromia. FHI often affects young adults and most often involves a single eye. People with FHI are at risk for cataract, glaucoma, and vitreous opacity (clouding of the jelly-like substance in the eyeball). The cause of FHI is not known. Click here to view a diagram of the eye.

MalaCards based summary : Fuchs' Heterochromic Uveitis, also known as fuchs heterochromic iridocyclitis, is related to retinal vasculitis and iridocyclitis. An important gene associated with Fuchs' Heterochromic Uveitis is TGFB2 (Transforming Growth Factor Beta 2), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and p70S6K Signaling. Affiliated tissues include eye, lung and skin, and related phenotype is immune system.

Disease Ontology : 12 A syndrome that is a chronic unilateral (or rarely bilateral) iridocyclitis appearing with the triad of heterochromia, predisposition to cataracts and glaucoma, and keratitic percipitates on the posterior corneal surface.

Related Diseases for Fuchs' Heterochromic Uveitis

Diseases related to Fuchs' Heterochromic Uveitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 397)
# Related Disease Score Top Affiliating Genes
1 retinal vasculitis 32.0 CCL2 ACE
2 iridocyclitis 31.1 IL6 ACE
3 iritis 30.9 IL6 ACE
4 chorioretinitis 30.7 IL6 IFNG ACE
5 chickenpox 30.6 IL6 IFNG
6 neovascular glaucoma 30.6 TGFB2 CXCL8
7 cataract 30.6 TGFB2 IL6 CXCL8 ACE
8 idiopathic anterior uveitis 30.6 IL6 CXCL8
9 open-angle glaucoma 30.5 TGFB2 IL6 ACE
10 intermediate uveitis 30.4 IL6 IFNG
11 uveitis 30.4 TGFB2 IL6 IFNG CXCL8 CCL2
12 endophthalmitis 30.4 IL6 CXCL8
13 syphilis 30.4 IL6 IFNG ACE
14 systemic scleroderma 30.3 IL6 IFNG ACE
15 sarcoidosis 1 30.2 IFNG CCL2 ACE
16 pulmonary sarcoidosis 30.0 IFNG CCL2 ACE
17 macular retinal edema 29.7 IL6 CXCL8 CCL2 ACE
18 macular holes 29.7 TGFB2 IL6 CXCL8 CCL2
19 retinal vascular disease 29.6 IL6 CXCL8 CCL2 ACE
20 retinal detachment 29.3 TGFB2 IL6 IFNG CXCL8 CCL2
21 eye disease 29.3 TGFB2 IL6 IFNG CXCL8 CCL2
22 hyperinsulinemic hypoglycemia, familial, 2 11.0
23 retinitis pigmentosa 10.5
24 neuroretinitis 10.5
25 retinitis 10.5
26 chikungunya 10.5
27 retinitis pigmentosa-deafness syndrome 10.4
28 intraocular pressure quantitative trait locus 10.4
29 usher syndrome 10.4
30 rubella 10.3
31 brawny scleritis 10.3 IFNG ACE
32 ocular tuberculosis 10.2 IFNG ACE
33 coloboma of macula 10.2
34 heterochromia iridis 10.2
35 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 10.2
36 coats disease 10.2
37 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 10.2
38 ifap syndrome 2 10.2
39 ptosis 10.2
40 absolute glaucoma 10.2
41 subclavian steal syndrome 10.2
42 facial hemiatrophy 10.2
43 fundus dystrophy 10.2
44 measles 10.2
45 glaucomatocyclitic crisis 10.2
46 toxocariasis 10.2
47 phacoanaphylactic uveitis 10.2
48 inherited retinal disorder 10.2
49 skin sarcoidosis 10.2 IFNG ACE
50 constrictive pericarditis 10.2 IFNG ACE

Graphical network of the top 20 diseases related to Fuchs' Heterochromic Uveitis:



Diseases related to Fuchs' Heterochromic Uveitis

Symptoms & Phenotypes for Fuchs' Heterochromic Uveitis

MGI Mouse Phenotypes related to Fuchs' Heterochromic Uveitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 immune system MP:0005387 9.17 ACE CCL2 ETS1 IFNG IL6 TGFB2

Drugs & Therapeutics for Fuchs' Heterochromic Uveitis

Search Clinical Trials , NIH Clinical Center for Fuchs' Heterochromic Uveitis

Genetic Tests for Fuchs' Heterochromic Uveitis

Anatomical Context for Fuchs' Heterochromic Uveitis

MalaCards organs/tissues related to Fuchs' Heterochromic Uveitis:

40
Eye, Lung, Skin, Bone, Heart, Brain, Spinal Cord

Publications for Fuchs' Heterochromic Uveitis

Articles related to Fuchs' Heterochromic Uveitis:

(show top 50) (show all 157)
# Title Authors PMID Year
1
Pattern of Uveitis in Iran: A Systematic Review. 61
33520132 2021
2
Clinical Features and Diagnosis of Anterior Segment Inflammation Related to Cytomegalovirus in Immunocompetent African, Asian, and Caucasian Patients. 61
31642720 2021
3
Polychromasia capsulare in Fuchs heterochromic iridocyclitis: case report and literature review. 61
32822659 2020
4
Comments on: Corneal endothelium in unilateral Fuchs heterochromic iridocyclitis. 61
32823480 2020
5
Response to comments on: Corneal endothelium in unilateral Fuchs heterochromic iridocyclitis. 61
32823481 2020
6
The outcome of initial mitomycin C-augmented trabeculectomy with subconjunctival bevacizumab in the management of secondary glaucoma associated with Fuchs heterochromic iridocyclitis. 61
31792855 2020
7
Analysis of retinal microvasculature in Fuchs' uveitis syndrome. Retinal microvasculature in Fuchs' uveitis. 61
32008841 2020
8
Corneal endothelium in unilateral Fuchs heterochromic iridocyclitis. 61
32056999 2020
9
A case of bilateral acute depigmentation of the Iris in one of two identical twins. 61
31906906 2020
10
Cornea Findings of Spectral Domain Anterior Segment Optical Coherence Tomography in Uveitic Eyes of Various Etiologies. 61
31335529 2019
11
Iris nodules in Fuchs heterochromic iridocyclitis. 61
31332130 2019
12
Predictive Factors of Intraocular Pressure Level Evolution Over Time and Glaucoma Severity in Fuchs' Heterochromic Iridocyclitis. 61
31157832 2019
13
Association of Ocular Inflammation and Rubella Virus Persistence. 61
30589932 2019
14
Primary glaucoma surgery in Fuchs' heterochromic uveitis: a comparison of trabeculectomy versus deep sclerectomy. 61
31453432 2019
15
Moth-eaten appearance of the iris in Fuchs heterochromic iridocyclitis. 61
30447956 2018
16
Fuchs heterochromic iridocyclitis-associated glaucoma: a retrospective comparison of primary Ahmed glaucoma valve implantation and trabeculectomy with mitomycin C. 61
30410728 2018
17
Risk Factors for Glaucoma in a Cohort of Patients with Fuchs Heterochromic Iridocyclitis. 61
27494676 2017
18
Phacoemulsification and Core Vitrectomy in Fuchs' Heterochromic Uveitis. 61
28638250 2017
19
Uveitis in São Paulo, Brazil: 1053 New Patients in 15 Months. 61
26914347 2017
20
Topical Ganciclovir in Cytomegalovirus Anterior Uveitis. 61
28426277 2017
21
Outcomes of phacoemulsification in patients with uveitis at a tertiary center in São Paulo, Brazil: a review of cases from 2007 to 2012. 61
28591283 2017
22
Phacoemulsification with primary implantation of an intraocular lens in patients with uveitis. 61
28860705 2017
23
Review of Epidemiology of Uveitis in Asia: Pattern of Uveitis in a Tertiary Hospital in the Philippines. 61
29083984 2017
24
The unusual association of inverse retinitis pigmentosa and Fuchs' heterochromic iridocyclitis. 61
28127443 2017
25
Niemann-Pick Disease Type C Associated with Fuchs Heterochromic Iridocyclitis. 61
29387679 2017
26
Iris autofluorescence in Fuchs' heterochromic uveitis. 61
26758535 2016
27
Phacoemulsification Versus Manual Small Incision Cataract Surgery in Patients With Fuchs Heterochromic Iridocyclitis. 61
26939115 2016
28
Rubella Virus-associated Anterior Uveitis in a Vaccinated Patient: A Case Report. 61
24945813 2016
29
Fuchs' Heterochromic Iridocyclitis in an Italian Tertiary Referral Centre: Epidemiology, Clinical Features, and Prognosis. 61
27781126 2016
30
The Manchester Uveitis Clinic: the first 3000 patients--epidemiology and casemix. 61
24295124 2015
31
Bilateral uveitis and Usher syndrome: a case report. 61
25889597 2015
32
Characteristics of Cytomegalovirus Uveitis in Immunocompetent Patients. 61
25207970 2015
33
In-bag dislocation of intraocular lens in patients with uveitis: a case series. 61
25861401 2015
34
Small-incision cataract surgery in patients with Fuch's heterochromic iridocyclitis. 61
25680261 2014
35
Polymorphisms of TNFAIP3 gene in a Chinese Han population with fuchs heterochromic iridocyclitis. 61
23463983 2014
36
Implantation of iris-claw Artisan intraocular lens for aphakia in Fuchs' heterochromic iridocyclitis. 61
23571252 2014
37
Corneal decompensation in bilateral Fuchs heterochromic uveitis. 61
24513371 2014
38
Trends in patterns of anterior uveitis in a tertiary institution in singapore. 61
23617304 2013
39
Cytomegalovirus anterior uveitis in immunocompetent individuals following topical prostaglandin analogues. 61
23837444 2013
40
[Pharmacological pseudo-Fuchs]. 61
23768478 2013
41
Surgical management of secondary glaucoma in Fuchs' heterochromic iridocyclitis. 61
23519886 2013
42
Phacoemulsification with intraocular lens implantation in patients with anterior uveitis. 61
23692885 2013
43
Associations of Fuchs heterochromic iridocyclitis in a South Indian patient population. 61
23514352 2013
44
Viral causes of unexplained anterior uveitis in Thailand. 61
22241022 2012
45
Chikungunya virus iridocyclitis in Fuchs' heterochromic iridocyclitis. 61
22218256 2012
46
High concordance of intraocular antibody synthesis against the rubella virus and Fuchs heterochromic uveitis syndrome in Slovenia. 61
23233792 2012
47
Corneal astigmatism in unilateral Fuchs heterochromic iridocyclitis. 61
21595529 2011
48
Etiologies of chronic anterior uveitis at a tertiary referral center over 35 years. 61
21054197 2011
49
Usher syndrome associated with Fuchs' heterochromic uveitis: a case report. 61
21607024 2011
50
Fuchs' heterochromic iridocyclitis associated with ocular toxocariasis. 61
21331701 2011

Variations for Fuchs' Heterochromic Uveitis

Expression for Fuchs' Heterochromic Uveitis

Search GEO for disease gene expression data for Fuchs' Heterochromic Uveitis.

Pathways for Fuchs' Heterochromic Uveitis

Pathways related to Fuchs' Heterochromic Uveitis according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.9 TGFB2 IL6 IFNG CXCL8 CCL2 ACE
2
Show member pathways
12.86 TGFB2 IL6 CCL2 ACE
3
Show member pathways
12.63 IL6 IFNG CXCL8 CCL2
4 12.62 TGFB2 IL6 IFNG ETS1 CXCL8
5
Show member pathways
12.39 IL6 IFNG ETS1 CCL2
6 12.18 TGFB2 IL6 ETS1
7
Show member pathways
12.17 IL6 IFNG CCL2
8
Show member pathways
12.17 IL6 CXCL8 CCL2
9
Show member pathways
12.15 IL6 IFNG CXCL8
10
Show member pathways
12.15 IL6 IFNG CXCL8 CCL2
11
Show member pathways
12.1 TGFB2 IL6 ACE
12 12.08 IL6 CXCL8 CCL2
13
Show member pathways
12.08 TGFB2 IL6 IFNG CXCL8
14 12.07 TGFB2 IL6 IFNG
15 12.03 TGFB2 IL6 IFNG
16
Show member pathways
12.02 IL6 IFNG CXCL8
17 11.95 TGFB2 IL6 ETS1 CXCL8
18 11.92 IL6 CXCL8 CCL2
19 11.83 IL6 CXCL8 CCL2
20 11.79 IL6 IFNG CXCL8
21 11.78 IL6 IFNG CXCL8 CCL2
22
Show member pathways
11.72 TGFB2 IL6 IFNG
23 11.7 TGFB2 ETS1 CCL2
24 11.68 TGFB2 IL6 IFNG CXCL8
25 11.64 IL6 IFNG CXCL8
26 11.62 TGFB2 IL6 CXCL8 CCL2
27 11.51 IL6 CXCL8 CCL2
28 11.39 IL6 CXCL8 CCL2
29
Show member pathways
11.36 IL6 IFNG ETS1 CXCL8
30 11.32 TGFB2 IL6 IFNG CXCL8 CCL2
31 11.26 IL6 IFNG
32
Show member pathways
11.24 TGFB2 IFNG
33 11.2 TGFB2 IL6 IFNG CXCL8
34 11.18 IL6 IFNG
35 11.18 CCL2 ACE
36 11.18 IL6 CXCL8 CCL2
37 11.13 IL6 IFNG
38 11.05 IFNG CCL2
39 10.92 IL6 CXCL8
40 10.83 TGFB2 IL6 CXCL8 CCL2
41 10.72 TGFB2 IL6 IFNG CXCL8 CCL2
42 10.68 TGFB2 IL6

GO Terms for Fuchs' Heterochromic Uveitis

Cellular components related to Fuchs' Heterochromic Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.43 TGFB2 IL6 IFNG CXCL8 CCL2 ACE
2 extracellular space GO:0005615 9.1 TGFB2 IL6 IFNG CXCL8 CCL2 ACE

Biological processes related to Fuchs' Heterochromic Uveitis according to GeneCards Suite gene sharing:

(show all 20)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.84 TGFB2 IL6 IFNG ETS1
2 positive regulation of gene expression GO:0010628 9.8 IL6 IFNG ETS1 CXCL8
3 cellular response to lipopolysaccharide GO:0071222 9.72 IL6 CXCL8 CCL2
4 negative regulation of cell proliferation GO:0008285 9.71 TGFB2 IL6 ETS1 CXCL8
5 cell cycle arrest GO:0007050 9.63 TGFB2 IFNG CXCL8
6 positive regulation of chemokine production GO:0032722 9.59 IL6 IFNG
7 regulation of angiogenesis GO:0045765 9.58 IL6 ETS1
8 positive regulation of epithelial cell migration GO:0010634 9.58 TGFB2 IFNG
9 cellular response to fibroblast growth factor stimulus GO:0044344 9.57 CXCL8 CCL2
10 JAK-STAT cascade GO:0007259 9.56 IFNG CCL2
11 embryonic digestive tract development GO:0048566 9.52 TGFB2 CXCL8
12 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.51 IFNG CCL2
13 positive regulation of leukocyte adhesion to vascular endothelial cell GO:1904996 9.48 IL6 ETS1
14 negative regulation of gene expression GO:0010629 9.46 TGFB2 IFNG CXCL8 ACE
15 PERK-mediated unfolded protein response GO:0036499 9.43 CXCL8 CCL2
16 neutrophil chemotaxis GO:0030593 9.43 TGFB2 CXCL8 CCL2
17 neutrophil mediated immunity GO:0002446 9.37 IL6 ACE
18 positive regulation of NMDA glutamate receptor activity GO:1904783 9.32 IFNG CCL2
19 humoral immune response GO:0006959 9.13 IL6 IFNG CCL2
20 immune response GO:0006955 9.02 IL6 IFNG ETS1 CXCL8 CCL2

Molecular functions related to Fuchs' Heterochromic Uveitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 TGFB2 IL6 IFNG CXCL8 CCL2

Sources for Fuchs' Heterochromic Uveitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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