MCID: FNC005
MIFTS: 31

Functional Colonic Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Functional Colonic Disease

MalaCards integrated aliases for Functional Colonic Disease:

Name: Functional Colonic Disease 12 15
Colonic Diseases, Functional 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3877
MeSH 44 D003109
UMLS 73 C0009374

Summaries for Functional Colonic Disease

MalaCards based summary : Functional Colonic Disease, also known as colonic diseases, functional, is related to rumination disorder and pancreatic serous cystadenoma. An important gene associated with Functional Colonic Disease is KCNMA1 (Potassium Calcium-Activated Channel Subfamily M Alpha 1), and among its related pathways/superpathways is Serotonin Receptor 4/6/7 and NR3C Signaling. The drugs Pentoxifylline and Citalopram have been mentioned in the context of this disorder. Affiliated tissues include colon, brain and testes, and related phenotype is nervous system.

Related Diseases for Functional Colonic Disease

Diseases related to Functional Colonic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 rumination disorder 10.9 HTR7 PTCRA
2 pancreatic serous cystadenoma 10.7 PTCRA SYP
3 malignant glandular tumor of peripheral nerve sheath 10.7 SST SYP
4 adenoma of the pancreas 10.7 SST SYP
5 pancreatic somatostatinoma 10.7 SST SYP
6 gastrointestinal neuroendocrine tumor 10.6 SST SYP
7 solitary osseous plasmacytoma 10.6 B2M PTCRA
8 cutaneous ganglioneuroma 10.6 KIT SYP
9 yellow nail syndrome 10.6 CD40LG SST
10 mixed type thymoma 10.6 KIT SYP
11 diffuse glomerulonephritis 10.6 B2M CD40LG
12 hyperglobulinemic purpura 10.6 BRD4 CD40LG HSPG2
13 diffuse lipomatosis 10.6 BRD4 KANTR
14 danubian endemic familial nephropathy 10.6 B2M CD40LG
15 adenoid basal cell carcinoma 10.6 B2M KIT
16 endometrial small cell carcinoma 10.5 KIT SYP
17 mediastinal cancer 10.5 KIT SYP
18 pancreatoblastoma 10.5 SST SYP
19 ureter, cancer of 10.5 PTCRA SYP
20 trench fever 10.5 CD40LG KANTR
21 cerebral arteritis 10.5 CD40LG KANTR
22 geniculate herpes zoster 10.5 CD40LG KANTR
23 angiomyoma 10.5 KIT SYP
24 salivary gland disease 10.5 CD40LG HSPG2
25 carcinoid tumors, intestinal 10.5 SST SYP
26 japanese spotted fever 10.5 CD40LG KANTR
27 non-secretory myeloma 10.5 B2M CD40LG
28 facial hemiatrophy 10.5 CD40LG KANTR
29 meningeal melanomatosis 10.5 B2M SYP
30 brachial plexus neuritis 10.4 CD40LG KANTR
31 primary sjögren syndrome 10.4 B2M CD40LG HSPG2
32 laryngeal tuberculosis 10.4 CD59 KANTR
33 perivascular epithelioid cell tumor 10.4 KIT SYP
34 ampulla of vater neoplasm 10.4 SST SYP
35 postencephalitic parkinson disease 10.4 KANTR SYP
36 oculogyric crisis 10.4 B2M KANTR
37 dental abscess 10.3 KANTR KIT
38 optic disk drusen 10.3 KANTR KCNMA1
39 visual agnosia 10.3 KANTR SYP
40 central nervous system disease 10.2 BCHE CD40LG KANTR
41 nervous system disease 10.2 BCHE CD40LG KANTR
42 organ system benign neoplasm 10.2 KIT SST SYP
43 cerebellopontine angle tumor 10.2 KANTR PTCRA SYP
44 merkel cell carcinoma 10.2 KIT SST SYP
45 duodenogastric reflux 10.2 MLN SST
46 fallopian tube adenocarcinoma 10.1 CALB2 PTCRA
47 branch retinal artery occlusion 10.1 B2M CD40LG KANTR
48 pituitary-dependent cushing's disease 10.1 CD59 HTR4 SST
49 venous hemangioma 10.1 CALB2 SYP
50 small cell cancer of the lung 10.0 KIT SST SYP

Graphical network of the top 20 diseases related to Functional Colonic Disease:



Diseases related to Functional Colonic Disease

Symptoms & Phenotypes for Functional Colonic Disease

MGI Mouse Phenotypes related to Functional Colonic Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.32 SST SYP B2M CALB2 CD40LG HSPG2

Drugs & Therapeutics for Functional Colonic Disease

Drugs for Functional Colonic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 288)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pentoxifylline Approved, Investigational Phase 4 6493-05-6 4740
2
Citalopram Approved Phase 4,Phase 2 59729-33-8 2771
3
Loperamide Approved Phase 4,Phase 2,Phase 3,Not Applicable 53179-11-6 3955
4
Curcumin Approved, Investigational Phase 4,Phase 2 458-37-7 969516
5
Rifaximin Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 80621-81-4 6436173
6
Amitriptyline Approved Phase 4 50-48-6 2160
7
Perphenazine Approved Phase 4 58-39-9 4748
8
Metronidazole Approved Phase 4 443-48-1 4173
9
Nitazoxanide Approved, Investigational, Vet_approved Phase 4 55981-09-4 41684
10
Pancrelipase Approved, Investigational Phase 4,Not Applicable 53608-75-6
11
Trimebutine Approved Phase 4,Phase 2,Phase 3 39133-31-8
12
Alverine Approved, Investigational Phase 4 150-59-4 3678
13
Mebeverine Approved, Investigational Phase 4 3625-06-7 62887
14
Simethicone Approved Phase 4,Phase 1 8050-81-5
15
Eluxadoline Approved, Investigational Phase 4,Phase 2 864821-90-9
16
Ebastine Approved, Investigational Phase 4 90729-43-4 3191
17
Histamine Approved, Investigational Phase 4,Phase 2 75614-87-8, 51-45-6 774
18
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
19
Norepinephrine Approved Phase 4 51-41-2 439260
20
Ondansetron Approved Phase 4,Phase 2 99614-02-5 4595
21
Paroxetine Approved, Investigational Phase 4 61869-08-7 43815
22
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 2 148553-50-8 5486971
23 Ramosetron Approved, Investigational Phase 4,Phase 3,Phase 2 132036-88-5
24
Glycerol Approved, Investigational Phase 4 56-81-5 753
25
Gabapentin Approved, Investigational Phase 4 60142-96-3 3446
26
gamma-Aminobutyric acid Approved, Investigational Phase 4 56-12-2 119
27
Vitamin D Approved, Nutraceutical, Vet_approved Phase 4,Phase 1,Not Applicable 1406-16-2
28
Vitamin D3 Approved, Nutraceutical Phase 4,Phase 1 67-97-0 6221 5280795
29
Citric Acid Approved, Nutraceutical, Vet_approved Phase 4,Phase 3 77-92-9 311
30 Tiropramide Investigational Phase 4 55837-29-1 42262
31 Mosapride Investigational Phase 4,Phase 3,Phase 2 112885-41-3
32
Daidzein Experimental Phase 4 486-66-8 5281708
33
Genistein Investigational Phase 4 446-72-0 5280961
34 Fenoverine Investigational Phase 4 37561-27-6
35
Maleic acid Experimental Phase 4 110-16-7 444266
36 Sulfalene Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
37 Anticonvulsants Phase 4,Phase 2
38 Autonomic Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
39 Bromides Phase 4,Not Applicable
40 calcium channel blockers Phase 4,Phase 2,Not Applicable
41 Calcium, Dietary Phase 4,Phase 3,Phase 2,Not Applicable
42 Cholinergic Agents Phase 4,Phase 2,Phase 1,Early Phase 1,Not Applicable
43 Cholinergic Antagonists Phase 4,Phase 2,Phase 1,Early Phase 1,Not Applicable
44 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
45 Muscarinic Antagonists Phase 4,Phase 2,Phase 1,Early Phase 1,Not Applicable
46 Neurotransmitter Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
47 Octylonium Phase 4
48 Parasympatholytics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
49 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1
50 Antioxidants Phase 4,Phase 2,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 561)
# Name Status NCT ID Phase Drugs
1 Safety and Therapeutic Efficacy of Phosphate Enema (Kleen Enema) in Patients Undergoing Sigmoidoscopy Unknown status NCT02386904 Phase 4 Phosphate Enema (Kleen® Enema)
2 The Efficacy of Hydrolyzed Guar Gum ( PHGG) in the Treatment of Patients With Irritable Bowel Syndrome (IBS) Unknown status NCT01779765 Phase 4
3 Changes in Gastrointestinal Microbiota Using VSL#3 in Patients With IBS-D Unknown status NCT01638208 Phase 4 VSL#3
4 Effect of Clostridium Butyricum in Treating Irritable Bowel Syndrome Unknown status NCT02614963 Phase 4 Clostridium Butyricum;placebo
5 Pain Relief In Irritable Bowel Syndrome Unknown status NCT02573844 Phase 4 Proklama
6 Is Microbiota Community Associated With Clinical Response to a Low FODMAP Diet in Patients With Irritable Bowel Syndrome Unknown status NCT02565550 Phase 4
7 Comparison of the Efficacy and Safety of Tiropramide and Octylonium in the Treatment of Irritable Bowel Syndrome Unknown status NCT01629212 Phase 4 Tiropramide HCl 100mg;Octylonium bromide 20mg
8 Effect of Pentoxifylline on Tight Junctions (TJs) of Intestinal Mucosa in Patients With Irritable Bowel Syndrome(IBS) Unknown status NCT01542268 Phase 4 pentoxifylline;pentoxifylline placebo
9 Lactibiane Tolérance® in Individuals Suffering From Irritable Bowel Syndrome With Diarrheal Predominance Unknown status NCT02728063 Phase 4
10 Effect of Mosapride on Gut Transit in Patients With Chronic Constipation or Constipated Irritable Bowel Syndrome and Healthy Subjects Unknown status NCT02433847 Phase 4 Mosapride
11 Manipulation of Visceral Sensitivity and Immune System in IBS Unknown status NCT00418340 Phase 4 probiotic (bacterial/dietary supplement)
12 Saccharomyces Boulardii in Diarrhea Dominant Irritable Bowel Syndrome Unknown status NCT00543478 Phase 4 Saccharomyces boulardii;Methyl cellulose powder (low viscosity)
13 Effect of Cholecalciferol, Soy Isoflavones in Patients With Irritable Bowel Syndrome Completed NCT02026518 Phase 4
14 Study to Assess the Effect Of Alosetron On Mucosal Blood Flow Completed NCT00370032 Phase 4 alosetron
15 EFESO - EFficacy Enterogermina Small Intestinal Bacterial Overgrowth Completed NCT00331994 Phase 4 Bacillus clausii;Metronidazole
16 Bifidobacteria In Children With Abdominal Pain-Associated Functional Gastrointestinal Disorders Completed NCT02566876 Phase 4 Mixture of three Bifidobacteria
17 Multi-strain Probiotic in the Management of IBS-D Completed NCT03251625 Phase 4 Probiotic Formula Capsule
18 Escitalopram Trial for Irritable Bowel Syndrome (IBS) Patients With Panic Disorder Completed NCT01551225 Phase 4 Escitalopram
19 Efficacy Evaluation of a Commercial Preparation Containing Lactobacillus Casei DG on the Reduction of the Painful Symptoms Related to the Irritable Bowel Syndrome (IBS). A Pilot Clinical Study Completed NCT02077699 Phase 4
20 Effect of Lactobacillus Plantarum 299v on Symptoms of Irritable Bowel Syndrome Completed NCT01886781 Phase 4 Lactobacillus plantarum 299v;Placebo comparator
21 Probiotic in Irritable Bowel Syndrome (IBS) Patients With Diarrhea Completed NCT01667627 Phase 4
22 Irritable Bowel Syndrome Evaluation and Treatment in Primary Care Completed NCT01641341 Phase 4 Bifidobacterium infantis;Pancrelipase;Nitazoxanide;Placebo
23 Mode of Action of Moviprep Completed NCT01622972 Phase 4 Polyethyleneglycol
24 Comparative Efficacy and Safety of Fenoverine Completed NCT01507922 Phase 4 Fenoverine;Timebutine
25 Effectiveness of On-demand Meteospasmyl® Use in Irritable Bowel Syndrome (IBS) Completed NCT01404923 Phase 4 anti spasmodic agents;alverine citrate, simeticone
26 Efficacy of Eluxadoline in the Treatment of Irritable Bowel Syndrome With Diarrhea in Patients With Inadequate Control of Symptoms With Prior Loperamide Use Completed NCT02959983 Phase 4 Eluxadoline;Placebo
27 Irritable Bowel Syndrome (IBS) Treatment With H1-receptor Antagonists Completed NCT01144832 Phase 4 ebastine;placebo capsule
28 Manipulation of Visceral Hypersensitivity With Probiotic Bacteria in Irritable Bowel Syndrome Completed NCT01139736 Phase 4
29 An Open Label Trial of Duloxetine in the Treatment of Irritable Bowel Syndrome and Comorbid Generalized Anxiety Disorder Completed NCT00961298 Phase 4 Duloxetine
30 An Open-Label, Long-term Study to Assess the Immunogenicity of Linaclotide Administered Orally to Adult Patients With Irritable Bowel Syndrome With Constipation or Chronic Idiopathic Constipation Completed NCT02590432 Phase 4 Linaclotide 290 micrograms;Linaclotide 145 micrograms;Linaclotide 72 micrograms
31 Management of Irritable Bowel Syndrome in Primary Care (MIBS Trial) Completed NCT00934973 Phase 4 mebeverine;methylcellulose;placebo
32 Curcumin (Tumeric) in the Treatment of Irritable Bowel Syndrome: A Randomized-Controlled Trial Completed NCT00779493 Phase 4
33 Ondansetron for the Treatment of IBS With Diarrhoea (IBS-D) Completed NCT00745004 Phase 4 Ondansetron;Placebo
34 Validation of Surrogate Measures in Irritable Bowel Syndrome (IBS) Completed NCT00693732 Phase 4 Escitalopram treatment
35 Ability of Mayo Clinic High-performance Liquid Chromatography (HPLC) Method to Measure Fecal Bile Acids Completed NCT02111603 Phase 4 Colesevelam
36 Paroxetine - Controlled Release in the Treatment of Irritable Bowel Syndrome (IBS) Completed NCT00610909 Phase 4 Paroxetine CR;Placebo
37 Efficacy and Safety of Meteospasmyl® in Irritable Bowel Syndrome Completed NCT00542295 Phase 4 alverine citrate and simeticone;placebo
38 An Open-Label Trial of Duloxetine for the Treatment of Irritable Bowel Syndrome Completed NCT00401258 Phase 4 duloxetine
39 Efficacy of Tegaserod in Relieving the Symptoms of Female Patients With Irritable Bowel Syndrome (IBS), Excluding Those With Predominant Diarrhea IBS Completed NCT00142987 Phase 4 Tegaserod
40 Pregabalin on Colonic Motor and Sensory Function in Constipation Predominant Irritable Bowel Syndrome Completed NCT01331213 Phase 4 Pregabalin;Placebo
41 Mesalazine for the Treatment of Diarrhoea-predominant Irritable Bowel Syndrome (IBS-D) Completed NCT01316718 Phase 4 Mesalazine;Placebo
42 Open Trial of Duloxetine in Outpatients With Irritable Bowel Syndrome Symptoms and Co-Morbid Major Depression Completed NCT01754493 Phase 4 Duloxetine
43 A Study to Evaluate Efficacy of Ramosetron on Diarrhea-predominant Irritable Bowel Syndrome (IBS) in Male Patients Completed NCT01225237 Phase 4 Ramosetron;Placebo
44 A Preliminary Study to Explore Clinical Endpoints in Patients (Male) With Diarrhea-predominant Irritable Bowel Syndrome Completed NCT00918411 Phase 4 Ramosetron;Placebo
45 A Longitudinal Study to Identify IBS Phenotypes Using Fecal Microbiota and Hydrogen Breath Testing Recruiting NCT03219528 Phase 4 Rifaximin 550 MG
46 Peripheral Histamine 1 Receptor Blockade in IBS: Multicenter Trial Recruiting NCT01908465 Phase 4 Ebastine;Placebo
47 Changes in Microbiota and Metabolomic Profile Between Rifaximin Responders and Non-responders In Diarrhoea-Predominant Irritable Bowel Syndrome Recruiting NCT03557788 Phase 4 Rifaximin Oral Tablet
48 3030-401-002 ELX BAM Study Recruiting NCT03441581 Phase 4 Eluxadoline
49 A Study of the Effect of Linaclotide on Abdominal Girth in Participants With IBS-C Recruiting NCT02837783 Phase 4 Linaclotide;Placebo
50 A Within Subjects Comparison of Two Antegrade Flushing Regimens in Children Recruiting NCT02435069 Phase 4 NS and USP Glycerin - Dose Response;NS and USP Glycerin - Effectiveness

Search NIH Clinical Center for Functional Colonic Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: colonic diseases, functional

Genetic Tests for Functional Colonic Disease

Anatomical Context for Functional Colonic Disease

MalaCards organs/tissues related to Functional Colonic Disease:

41
Colon, Brain, Testes, Spinal Cord, Small Intestine, Liver, Heart

Publications for Functional Colonic Disease

Variations for Functional Colonic Disease

Expression for Functional Colonic Disease

Search GEO for disease gene expression data for Functional Colonic Disease.

Pathways for Functional Colonic Disease

Pathways related to Functional Colonic Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.9 HTR4 HTR7

GO Terms for Functional Colonic Disease

Cellular components related to Functional Colonic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.17 B2M BCHE CD40LG CD59 HSPG2 KIT

Molecular functions related to Functional Colonic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G-protein coupled serotonin receptor activity GO:0004993 8.62 HTR4 HTR7

Sources for Functional Colonic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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