MCID: FNC005
MIFTS: 21

Functional Colonic Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Functional Colonic Disease

MalaCards integrated aliases for Functional Colonic Disease:

Name: Functional Colonic Disease 12 15
Colonic Diseases, Functional 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3877
MeSH 44 D003109
UMLS 70 C0009374

Summaries for Functional Colonic Disease

MalaCards based summary : Functional Colonic Disease, also known as colonic diseases, functional, is related to rumination disorder and pylorospasm. An important gene associated with Functional Colonic Disease is MLNR (Motilin Receptor). The drugs Desipramine and Peppermint have been mentioned in the context of this disorder.

Related Diseases for Functional Colonic Disease

Graphical network of the top 20 diseases related to Functional Colonic Disease:



Diseases related to Functional Colonic Disease

Symptoms & Phenotypes for Functional Colonic Disease

Drugs & Therapeutics for Functional Colonic Disease

Drugs for Functional Colonic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desipramine Approved, Investigational Phase 3 50-47-5 2995
2
Peppermint Approved Phase 3
3
Peppermint oil Approved, Investigational Phase 3 8006-90-4
4 Cola Phase 3
5 Gastrointestinal Agents Phase 3
6 Neurotransmitter Agents Phase 3
7 Antidepressive Agents Phase 3
8 Psychotropic Drugs Phase 3
9 Adrenergic Agents Phase 3
10 Antidepressive Agents, Tricyclic Phase 3
11 Antiemetics Phase 3
12 Parasympatholytics Phase 3
13 Acidophilus Phase 1, Phase 2
14 Sulfalene Phase 1, Phase 2
15 Bifidobacterium Phase 1, Phase 2
16
Midazolam Approved, Illicit 59467-70-8 4192
17
Bisacodyl Approved 603-50-9
18
Fentanyl Approved, Illicit, Investigational, Vet_approved 437-38-7 3345
19
Propofol Approved, Investigational, Vet_approved 2078-54-8 4943
20
Calcium polycarbophil Approved 126040-58-2
21
Capsaicin Approved 404-86-4 1548943
22 Anesthetics
23 Hypnotics and Sedatives
24 Narcotics
25 Analgesics
26 Anesthetics, General
27 Analgesics, Opioid
28 Anesthetics, Intravenous
29 Cathartics
30 Laxatives
31 Psyllium
32 Pharmaceutical Solutions
33 Dermatologic Agents

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Multicenter Trial of Functional Bowel Disorders Completed NCT00006157 Phase 3 Desipramine
2 Peppermint Oil for the Treatment of Irritable Bowel Syndrome: Optimizing Therapeutic Strategies Using Targeted Delivery Completed NCT02716285 Phase 3 Ileocolonic release peppermint oil;Placebo;Small intestinal release peppermint oil
3 Clinical Study to Test the Efficacy of Herbal Medicine in Relieving Symptoms and Change of Quality of Life of Patients With IBS Completed NCT00153751 Phase 2 Traditional Chinese Medicine;Holopon
4 The Effect of Kyo-Dophilus 1.5 Billion on the Symptoms of Severe Irritable Bowel Syndrome Completed NCT01887834 Phase 1, Phase 2
5 The Effect of Kyo-Dophilus 1.5 Billion on the Symptoms of Irritable Bowel Syndrome (IBS) Completed NCT01176227 Phase 1, Phase 2
6 A Phase I, Double-Blind, Placebo-Controlled, Randomized, Parallel-Group Study to Evaluate the Safety and Efficacy of a Combination Herbal Therapy (CHT), Versus Placebo in Improving the Overall Quality of Life and Symptoms in Patients With Irritable Bowel Syndrome (IBS) Completed NCT00130741 Phase 1 CHT - herbal therapy
7 Which Position is Suitable for Easy, Fast and Comfortable Colonoscopy Unknown status NCT03854422
8 Screening and Identification of Abnormal Expression Proteins and miRNA From Colonic Mucosa of Patients With Irritable Bowel Syndrome. Unknown status NCT01028898
9 Could Lumbo-sacral Magnetic Stimulation Modify Recto-colonic Motility? Completed NCT00213317
10 Influence of Adequacy of Anaesthesia Monitoring on Both Operators' and Patients' Satisfaction in Patients Undergoing Colonoscopic Procedures Completed NCT03922815 rescue fentanyl;rescue propofol
11 Dietary Interventions in Irritable Bowel Syndrome: Soluble, Insoluble or no Fibre? A Randomized Controlled Trial in Primary Care. Completed NCT00189033 psyllium fibre (dietary supplement);wheat bran (dietary supplement);rice wheat (placebo)
12 The Role of Intestinal Inflammation in the Pathophysiology of IBS Completed NCT01072903
13 Brain and Brainstem Activation Following Duodenal Nociceptive Stimulation With Capsaicin, an Exploratory High-resolution fMRI Study in Healthy Volunteers Completed NCT02551029
14 Evaluation of a Novel Colonoscope Designed for Easier Passage Through Flexures: A Randomised Study Completed NCT00518349

Search NIH Clinical Center for Functional Colonic Disease

Inferred drug relations via UMLS 70 / NDF-RT 51 :


Loperamide
Loperamide Hydrochloride

Cochrane evidence based reviews: colonic diseases, functional

Genetic Tests for Functional Colonic Disease

Anatomical Context for Functional Colonic Disease

Publications for Functional Colonic Disease

Articles related to Functional Colonic Disease:

# Title Authors PMID Year
1
The Incidence of Sexual Dysfunction in Patients With Irritable Bowel Syndrome. 61
31604682 2019
2
Effectiveness of osteopathic manipulative therapy for managing symptoms of irritable bowel syndrome: a systematic review. 61
24917634 2014
3
Role of radiologic imaging in irritable bowel syndrome: evidence-based review. 61
22156992 2012
4
Tegaserod for the treatment of irritable bowel syndrome and chronic constipation. 61
17943807 2007
5
Tegaserod for the treatment of irritable bowel syndrome. 61
14974049 2004
6
[Functional colonic disease and psychopathology. Importance of affective experiences]. 61
3662417 1987
7
[Pinaverium bromide and functional colonic disease (double-blind study]. 61
339352 1977
8
[Functional colonic disease]. 61
4715892 1973

Variations for Functional Colonic Disease

Expression for Functional Colonic Disease

Search GEO for disease gene expression data for Functional Colonic Disease.

Pathways for Functional Colonic Disease

GO Terms for Functional Colonic Disease

Biological processes related to Functional Colonic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.26 SST MLNR MLN CCL13
2 response to nutrient GO:0007584 8.62 SST BCHE

Sources for Functional Colonic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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