MCID: FNC005
MIFTS: 26

Functional Colonic Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Functional Colonic Disease

MalaCards integrated aliases for Functional Colonic Disease:

Name: Functional Colonic Disease 12 15
Colonic Diseases, Functional 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3877
MeSH 44 D003109
UMLS 73 C0009374

Summaries for Functional Colonic Disease

MalaCards based summary : Functional Colonic Disease, also known as colonic diseases, functional, is related to hyperglobulinemic purpura and rumination disorder. An important gene associated with Functional Colonic Disease is KCNMA1 (Potassium Calcium-Activated Channel Subfamily M Alpha 1), and among its related pathways/superpathways are Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics and Serotonin Receptor 4/6/7 and NR3C Signaling. The drugs Desipramine and Neurotransmitter Uptake Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include colon, lung and kidney, and related phenotype is nervous system.

Related Diseases for Functional Colonic Disease

Diseases related to Functional Colonic Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 73)
# Related Disease Score Top Affiliating Genes
1 hyperglobulinemic purpura 10.3 BRD4 HSPG2
2 rumination disorder 10.3 HTR7 PTCRA
3 pancreatic serous cystadenoma 10.2 PTCRA SYP
4 malignant glandular tumor of peripheral nerve sheath 10.2 SST SYP
5 adenoma of the pancreas 10.2 SST SYP
6 pancreatic somatostatinoma 10.2 SST SYP
7 gastrointestinal neuroendocrine tumor 10.2 SST SYP
8 pancreatic endocrine carcinoma 10.2 SST SYP
9 cutaneous ganglioneuroma 10.2 KIT SYP
10 solitary osseous plasmacytoma 10.2 B2M PTCRA
11 mixed type thymoma 10.2 KIT SYP
12 endometrial small cell carcinoma 10.2 KIT SYP
13 pancreatoblastoma 10.2 SST SYP
14 carcinoid tumors, intestinal 10.2 SST SYP
15 adenoid basal cell carcinoma 10.2 B2M KIT
16 diffuse lipomatosis 10.2 BRD4 KANTR
17 mediastinal cancer 10.2 KIT SYP
18 meningeal melanomatosis 10.2 B2M SYP
19 angiomyoma 10.2 KIT SYP
20 perivascular epithelioid cell tumor 10.2 KIT SYP
21 prostate small cell carcinoma 10.2 KIT SYP
22 postencephalitic parkinson disease 10.1 KANTR SYP
23 nervous system cancer 10.1 BCHE SST SYP
24 optic disk drusen 10.1 KANTR KCNMA1
25 laryngeal tuberculosis 10.1 CD59 KANTR
26 binswanger's disease 10.1 SST SYP
27 anterior cranial fossa meningioma 10.1 KANTR SYP
28 carcinoid syndrome 10.1 SST SYP
29 visual agnosia 10.1 KANTR SYP
30 dental abscess 10.1 KANTR KIT
31 extragonadal seminoma 10.1 BRD4 KIT
32 hemometra 10.1 HSPG2 KANTR
33 oculogyric crisis 10.1 B2M KANTR
34 abducens nerve disease 10.1 KANTR SYP
35 intraocular retinoblastoma 10.1 KANTR SYP
36 duodenogastric reflux 10.1 MLN SST
37 merkel cell carcinoma 10.1 KIT SST SYP
38 nervous system disease 10.1 BCHE KANTR SYP
39 small cell cancer of the lung 10.0 KIT SST SYP
40 cerebellopontine angle tumor 10.0 KANTR PTCRA SYP
41 fallopian tube adenocarcinoma 10.0 CALB2 PTCRA
42 pituitary-dependent cushing's disease 10.0 CD59 HTR4 SST
43 venous hemangioma 10.0 CALB2 SYP
44 meningioma, familial 10.0 KANTR SST SYP
45 ovarian fibrothecoma 10.0 CALB2 KIT
46 mucinous ovarian cystadenoma 10.0 CALB2 SYP
47 ovarian melanoma 10.0 CALB2 KIT
48 malignant leydig cell tumor 10.0 CALB2 KIT
49 peritoneal benign neoplasm 10.0 CALB2 KIT
50 diffuse peritoneal leiomyomatosis 10.0 CALB2 KIT

Graphical network of the top 20 diseases related to Functional Colonic Disease:



Diseases related to Functional Colonic Disease

Symptoms & Phenotypes for Functional Colonic Disease

MGI Mouse Phenotypes related to Functional Colonic Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.28 B2M CALB2 HSPG2 HTR4 HTR7 KCNMA1

Drugs & Therapeutics for Functional Colonic Disease

Drugs for Functional Colonic Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Desipramine Approved, Investigational Phase 3 50-47-5 2995
2 Neurotransmitter Uptake Inhibitors Phase 3
3 Psychotropic Drugs Phase 3
4 Antidepressive Agents Phase 3
5 Antidepressive Agents, Tricyclic Phase 3
6 Neurotransmitter Agents Phase 3
7 Adrenergic Agents Phase 3
8
Bisacodyl Approved 603-50-9
9 Cola

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Functional Bowel Disorders Completed NCT00006157 Phase 3 Desipramine
2 Effect of Lumbo-sacral Magnetic Stimulation on Colonic Motility Completed NCT00213317
3 Colonoscope Passive Bending Function Completed NCT00518349 Not Applicable

Search NIH Clinical Center for Functional Colonic Disease

Inferred drug relations via UMLS 73 / NDF-RT 51 :


Cochrane evidence based reviews: colonic diseases, functional

Genetic Tests for Functional Colonic Disease

Anatomical Context for Functional Colonic Disease

MalaCards organs/tissues related to Functional Colonic Disease:

41
Colon, Lung, Kidney, Ovary, Pancreas, Testis, Thymus

Publications for Functional Colonic Disease

Variations for Functional Colonic Disease

Expression for Functional Colonic Disease

Search GEO for disease gene expression data for Functional Colonic Disease.

Pathways for Functional Colonic Disease

Pathways related to Functional Colonic Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.4 HTR4 HTR7
2 9.9 HTR4 HTR7

GO Terms for Functional Colonic Disease

Biological processes related to Functional Colonic Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to cadmium ion GO:0046686 8.62 B2M KIT

Sources for Functional Colonic Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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