MCID: FNC002
MIFTS: 39

Functional Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Functional Diarrhea

MalaCards integrated aliases for Functional Diarrhea:

Name: Functional Diarrhea 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:11371
ICD9CM 35 564.5
SNOMED-CT 68 47812002
ICD10 33 K59.1
UMLS 72 C0156173

Summaries for Functional Diarrhea

MalaCards based summary : Functional Diarrhea is related to constipation and celiac disease 1, and has symptoms including constipation, diarrhea and vomiting following gastrointestinal surgery. An important gene associated with Functional Diarrhea is FGF19 (Fibroblast Growth Factor 19), and among its related pathways/superpathways are Cytoskeletal Signaling and Endothelins. The drugs Loperamide and Clonidine have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and small intestine, and related phenotypes are growth/size/body region and homeostasis/metabolism

Related Diseases for Functional Diarrhea

Diseases related to Functional Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 66)
# Related Disease Score Top Affiliating Genes
1 constipation 30.0 TAC1 NTS HTR3A FGF19
2 celiac disease 1 29.6 TOR1A TGM2 GHRL
3 lymphocytic colitis 29.4 ATP4A ATP12A
4 fungal esophagitis 10.6 ATP4A ATP12A
5 gastroduodenal crohn's disease 10.6 ATP4A ATP12A
6 diclofenac allergy 10.6 ATP4A ATP12A
7 neonatal candidiasis 10.6 ATP4A ATP12A
8 squamous papillomatosis 10.6 ATP4A ATP12A
9 photoallergic dermatitis 10.6 ATP4A ATP12A
10 gastrointestinal neuroendocrine benign tumor 10.6 ATP4A ATP12A
11 aspiration pneumonitis 10.6 ATP4A ATP12A
12 toxic megacolon 10.6 ATP4A ATP12A
13 granulomatous gastritis 10.5 ATP4A ATP12A
14 gastric antral vascular ectasia 10.5 ATP4A ATP12A
15 acute laryngitis 10.5 ATP4A ATP12A
16 laryngitis 10.5 ATP4A ATP12A
17 gastric neuroendocrine neoplasm 10.5 ATP4A ATP12A
18 esophageal candidiasis 10.5 ATP4A ATP12A
19 duodenitis 10.5 ATP4A ATP12A
20 active peptic ulcer disease 10.5 ATP4A ATP12A
21 wheat allergy 10.5 TOR1A TGM2
22 dyskinesia of esophagus 10.5 ATP4A ATP12A
23 peptic esophagitis 10.4 ATP4A ATP12A
24 capillary disease 10.4 ATP4A ATP12A
25 diarrhea 10.4
26 rumination disorder 10.4 HTR3A ATP4A ATP12A
27 bile reflux 10.4 ATP4A ATP12A
28 superior mesenteric artery syndrome 10.4 HTR3A ATP4A ATP12A
29 ischemic neuropathy 10.4 ATP4A ATP12A
30 bladder calculus 10.4 ATP4A ATP12A
31 congenital disorder of deglycosylation 10.3 ATP4A ATP12A
32 microinvasive gastric cancer 10.3 CDH1 ATP4A ATP12A
33 laryngeal disease 10.3 CDH1 ATP4A ATP12A
34 hernia, hiatus 10.3 ATP4A ATP12A
35 blind loop syndrome 10.2 GHRL ATP4A ATP12A
36 irritable bowel syndrome 10.2
37 postsurgical hypothyroidism 10.2 ATP4A ATP12A
38 anismus 10.2 TAC1 ATP4A ATP12A
39 aspiration pneumonia 10.2 TAC1 ATP4A ATP12A
40 glomangiosarcoma 10.2 TAC1 DNTT
41 paine syndrome 10.2 TAC1 ATP4A ATP12A
42 esophageal atresia/tracheoesophageal fistula 10.1 ATP4A ATP12A
43 immune system disease 10.1 TOR1A TGM2 CDH1
44 functional gastric disease 10.0 HTR3A GHRL ATP4A ATP12A
45 motion sickness 10.0 TAC1 HTR3A FOS
46 pain agnosia 10.0 TAC1 NTS FOS
47 agnosia 10.0 TAC1 NTS FOS
48 stomach disease 9.9 GHRL CDH1 ATP4A ATP12A
49 gastrointestinal system disease 9.9 GHRL CDH1 ATP4A ATP12A
50 overgrowth syndrome 9.9

Comorbidity relations with Functional Diarrhea via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Functional Diarrhea:



Diseases related to Functional Diarrhea

Symptoms & Phenotypes for Functional Diarrhea

UMLS symptoms related to Functional Diarrhea:


constipation, diarrhea, vomiting following gastrointestinal surgery

MGI Mouse Phenotypes related to Functional Diarrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.17 ATP12A CDH1 CDK5RAP2 EDN1 FGF19 FOS
2 homeostasis/metabolism MP:0005376 10.13 ATP12A ATP4A CDH1 DNTT EDN1 FGF19
3 endocrine/exocrine gland MP:0005379 10.07 ATP4A CDH1 EDN1 FOS GHRL GPBAR1
4 digestive/alimentary MP:0005381 10.01 ATP12A ATP4A CDH1 EDN1 GHRL NR1H4
5 immune system MP:0005387 9.9 ATP4A CDH1 CDK5RAP2 DNTT FOS GPBAR1
6 mortality/aging MP:0010768 9.73 ATP4A CDH1 CDK5RAP2 EDN1 FGF19 FOS
7 neoplasm MP:0002006 9.17 ATP4A CDH1 CDK5RAP2 FOS MMP1 NR1H4

Drugs & Therapeutics for Functional Diarrhea

Drugs for Functional Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 34)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loperamide Approved Phase 2, Phase 3 53179-11-6 3955
2
Clonidine Approved Phase 3 4205-90-7 2803
3 Gastrointestinal Agents Phase 2, Phase 3
4 Antidiarrheals Phase 2, Phase 3
5 Neurotransmitter Agents Phase 3
6 Antihypertensive Agents Phase 3
7 Analgesics Phase 3
8 Adrenergic alpha-2 Receptor Agonists Phase 3
9 Adrenergic Agonists Phase 3
10 Adrenergic alpha-Agonists Phase 3
11 Lipid Regulating Agents Phase 3
12 Colesevelam Hydrochloride Phase 3
13 Adrenergic Agents Phase 3
14 Sympatholytics Phase 3
15 Hypolipidemic Agents Phase 3
16 Anticholesteremic Agents Phase 3
17 Peripheral Nervous System Agents Phase 3
18 Bile Acids and Salts Phase 3
19 Autonomic Agents Phase 3
20 Antimetabolites Phase 3
21 Cola Phase 2
22
Sodium citrate Approved, Investigational Phase 1 68-04-2
23
Citric acid Approved, Nutraceutical, Vet_approved Phase 1 77-92-9 311
24
Calcium Approved, Nutraceutical Phase 1 7440-70-2 271
25 Mosapride Investigational Phase 1 112885-41-3
26 Citrate Phase 1
27 Serotonin Receptor Agonists Phase 1
28 Chelating Agents Phase 1
29 Serotonin Agents Phase 1
30 Anticoagulants Phase 1
31 Calcium, Dietary Phase 1
32
Serotonin Investigational, Nutraceutical Phase 1 50-67-9 5202
33 Acidophilus
34 Bifidobacterium

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acupuncture for Functional Bowel Disease Completed NCT01350570 Phase 2, Phase 3 Loperamide
2 A Placebo Controlled Study of Colesevelam in Fecal Incontinence Recruiting NCT02628626 Phase 3 Colesevelam;Clonidine
3 A Phase IIB Study to Evaluate the Effects of Welchol (Colesevelam Hydrochloride) on Colonic Transit, Intestinal Permeability and Bowel Function in Diarrhea-predominant Irritable Bowel Syndrome (D-IBS) Completed NCT00911612 Phase 2 Colesevelam;Placebo
4 Multicentre Randomized Controlled Trial for Quantity-Effect Relationship of Acupuncture With Two-ways Regulation to Treat Functional Enteropathy Unknown status NCT01274793 Phase 1 Mosapride Citrate tablet
5 Assessment of Elemental Impurities Level After Chronic Administration of Diosmectite (SMECTA®) in Subjects With Chronic Diarrhoea Completed NCT03045926 Phase 1 Diosmectite (Smecta®)
6 Clinical Efficacy of Probiotic Bacteria in Subjects With Irritable Bowel Syndrome (IBS), Functional Diarrhea, or Functional Bloating Completed NCT00618904
7 Gluten Intolerance in Irritable Bowel Syndrome With Diarrhea: The Role of HLA-DQ2 Completed NCT01094041
8 Clinical Efficacy of Yogurt Containing Bifidobacterium Lactis (BB12) in Subjects With Functional Gastrointestinal Symptoms Completed NCT00618488

Search NIH Clinical Center for Functional Diarrhea

Genetic Tests for Functional Diarrhea

Anatomical Context for Functional Diarrhea

MalaCards organs/tissues related to Functional Diarrhea:

41
Colon, Testes, Small Intestine, Brain, Thyroid, Hypothalamus

Publications for Functional Diarrhea

Articles related to Functional Diarrhea:

(show top 50) (show all 144)
# Title Authors PMID Year
1
AGA Guideline on the Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D). 38
31377275 2019
2
AGA Guideline on the Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D). 38
31302098 2019
3
AGA Guidelines on the Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in adults (IBS-D): Patient Summary. 38
31378676 2019
4
[Electroacupuncture improves intestinal function by down-regulating expression of 5-HT1AR and c-fos proteins in the hypothalamus and colon tissues via brain-gut axis in rats with functional diarrhea]. 38
31368281 2019
5
AGA Technical Review on the Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults. 38
31351880 2019
6
Chronic Diarrhea Evaluation in the Elderly: IBS or Something Else? 38
31346793 2019
7
The Microbiome in Functional Gastrointestinal Disorders Is Characterized by Bacteria and Genes Involved in Carbohydrate and Bile Acid Metabolism (OR23-01-19). 38
31224674 2019
8
Neonatal Antibiotics and Prematurity Are Associated with an Increased Risk of Functional Gastrointestinal Disorders in the First Year of Life. 38
31201028 2019
9
[Zaburzenia czynnoĹ›ciowe przewodu pokarmowego u osób z przerostem bakteryjnym jelita cienkiego]. 38
31260431 2019
10
Epidemiological, Clinical, and Psychological Characteristics of Individuals with Self-reported Irritable Bowel Syndrome Based on the Rome IV vs Rome III Criteria. 38
31154027 2019
11
Analysis of Fecal Primary Bile Acids Detects Increased Stool Weight and Colonic Transit in Patients With Chronic Functional Diarrhea. 38
29902647 2019
12
Adverse drug reactions of Yunnan Baiyao capsule: a multi-center intensive monitoring study in China. 38
31032273 2019
13
Rebamipide increases the disaccharidases activity in patients with enteropathy with impaired membrane digestion. Pilot study. 38
31094168 2019
14
Risk factors for upper and lower functional gastrointestinal disorders in Persian Gulf War Veterans during and post-deployment. 38
30697884 2019
15
The Relation between Dietary Patterns and Functional Gastrointestinal Disorders among Iranian Military Men. 38
30775344 2019
16
Beneficial effects of Saccharomyces boulardii CNCM I-745 on clinical disorders associated with intestinal barrier disruption. 38
30804678 2019
17
Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder. 38
30350113 2019
18
Clinical and psychological correlates of soiling in adult patients with functional gastrointestinal disorders. 38
29987361 2018
19
Use of Bioelectronics in the Gastrointestinal Tract. 38
30249600 2018
20
The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study. 38
29684865 2018
21
Association Between Ultra-Processed Food Consumption and Functional Gastrointestinal Disorders: Results From the French NutriNet-Santé Cohort. 38
29904158 2018
22
Multicenter observational study on functional bowel disorders diagnosed using Rome III diagnostic criteria in Japan. 38
29305648 2018
23
[Nutritional management of functional chronic diarrhea associated to malnutrition with peptide diet: a case report]. 38
29974788 2018
24
Functional Gastrointestinal Disorders: Functional Gastrointestinal Disorders in Children. 38
29528207 2018
25
[Influence of cow's milk protein allergy on the diagnosis of functional gastrointestinal diseases based on the Rome IV standard in infants and young children]. 38
29335084 2018
26
The role of fermentable carbohydrates and beverages in the symptomatology of functional gastrointestinal disease. 38
28826271 2017
27
Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity. 38
28573751 2017
28
Saccharomyces boulardii CNCM I-745 Restores intestinal Barrier Integrity by Regulation of E-cadherin Recycling. 38
28333335 2017
29
Rome foundation Asian working team report: Real world treatment experience of Asian patients with functional bowel disorders. 38
28084664 2017
30
What Is New in Rome IV. 38
28274109 2017
31
Diagnostic Yield and Clinical Impact of Video Capsule Endoscopy in Patients with Chronic Diarrhea: A Korean Multicenter CAPENTRY Study. 38
27840367 2017
32
The New Rome IV Criteria for Functional Gastrointestinal Disorders in Infants and Toddlers. 38
28401050 2017
33
Clinical, psychological, and physiological correlates of patients who defecate after meal. 38
27824643 2017
34
Acupuncture for chronic diarrhea in adults: Protocol for a systematic review. 38
28121941 2017
35
[Disaccharidase deficiency and functional bowel diseases]. 38
28514399 2017
36
Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders. 38
28049862 2017
37
Effects of electronically stimulating Tianshu (ST 25) and Dachangshu (BL 25), Quchi (LI 11) and Shangjuxu (ST 37) on the expressions of jejunum c-kit protein and c-kit mRNA in rats with functional diarrhea. 38
29949711 2016
38
Physical inactivity during leisure time and irregular meals are associated with functional gastrointestinal complaints in middle-aged and elder subjects. 38
27435884 2016
39
Smoking is associated with several functional gastrointestinal symptoms. 38
27160318 2016
40
Pharmacological interventions on early functional gastrointestinal disorders. 38
27423188 2016
41
Electroacupuncture for patients with diarrhea-predominant irritable bowel syndrome or functional diarrhea: A randomized controlled trial. 38
27310980 2016
42
Development and Validation of a Rome III Functional Gastrointestinal Disorders Questionnaire for Infants and Toddlers. 38
26308319 2016
43
Bowel Disorders. 38
27144627 2016
44
[FUNCTIONAL BLOATING, CONSTIPATION AND DIARRHEA]. 38
29083560 2015
45
Functional Gastrointestinal Disorders in Obese Patients. The Importance of the Enrollment Source. 38
25904236 2015
46
Pharmacologic Agents for Chronic Diarrhea. 38
26576135 2015
47
High Prevalence of Idiopathic Bile Acid Diarrhea Among Patients With Diarrhea-Predominant Irritable Bowel Syndrome Based on Rome III Criteria. 38
25769413 2015
48
Early investigational therapeutics for gastrointestinal motility disorders: from animal studies to Phase II trials. 38
25971881 2015
49
Bile Acid diarrhea: prevalence, pathogenesis, and therapy. 38
25918262 2015
50
Cytokine expression of microscopic colitis including interleukin-17. 38
25071069 2015

Variations for Functional Diarrhea

Expression for Functional Diarrhea

Search GEO for disease gene expression data for Functional Diarrhea.

Pathways for Functional Diarrhea

Pathways related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.95 VCL TOR1A RAB11A CDH1
2 10.86 MMP1 FOS EDN1
3 10.54 NR1H4 FGF19
4 10.47 FOS FGF19 CDH1

GO Terms for Functional Diarrhea

Cellular components related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.61 VCL TAC1 NTS MMP1 GHRL FGF19
2 transport vesicle GO:0030133 8.92 TOR1A RAB11A NTS EDN1

Biological processes related to Functional Diarrhea according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 regulation of pH GO:0006885 9.49 EDN1 ATP12A
2 regulation of blood vessel size GO:0050880 9.48 NTS EDN1
3 cellular sodium ion homeostasis GO:0006883 9.46 ATP4A ATP12A
4 response to muscle stretch GO:0035994 9.43 FOS EDN1
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.4 ATP4A ATP12A
6 positive regulation of renal sodium excretion GO:0035815 9.37 TAC1 EDN1
7 sodium ion export across plasma membrane GO:0036376 9.32 ATP4A ATP12A
8 cellular potassium ion homeostasis GO:0030007 9.26 ATP4A ATP12A
9 negative regulation of tumor necrosis factor secretion GO:1904468 9.16 NR1H4 GHRL
10 positive regulation of adipose tissue development GO:1904179 8.96 NR1H4 GHRL
11 negative regulation of bile acid biosynthetic process GO:0070858 8.62 NR1H4 FGF19

Molecular functions related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.43 GHRL EDN1 APELA
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP4A ATP12A
3 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A
4 bile acid receptor activity GO:0038181 8.62 NR1H4 GPBAR1

Sources for Functional Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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