MCID: FNC002
MIFTS: 36

Functional Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Functional Diarrhea

MalaCards integrated aliases for Functional Diarrhea:

Name: Functional Diarrhea 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:11371
ICD10 33 K59.1
ICD9CM 35 564.5
SNOMED-CT 68 47812002
UMLS 73 C0156173

Summaries for Functional Diarrhea

MalaCards based summary : Functional Diarrhea is related to irritable bowel syndrome and constipation, and has symptoms including constipation, diarrhea and vomiting following gastrointestinal surgery. An important gene associated with Functional Diarrhea is ITM2B (Integral Membrane Protein 2B), and among its related pathways/superpathways are Serotonergic synapse and Farnesoid X Receptor Pathway. The drugs Loperamide and Baclofen have been mentioned in the context of this disorder. Affiliated tissues include colon, and related phenotypes are Reduced mammosphere formation and behavior/neurological

Related Diseases for Functional Diarrhea

Diseases related to Functional Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 55)
# Related Disease Score Top Affiliating Genes
1 irritable bowel syndrome 28.6 HTR3A HTR4 HTR7 TAC1
2 constipation 27.8 FGF19 HTR3A HTR4 NTS TAC1
3 fungal esophagitis 10.7 ATP12A ATP4A
4 bladder calculus 10.7 ATP12A ATP4A
5 gastrointestinal neuroendocrine benign tumor 10.7 ATP12A ATP4A
6 neonatal candidiasis 10.7 ATP12A ATP4A
7 photoallergic dermatitis 10.7 ATP12A ATP4A
8 squamous papillomatosis 10.7 ATP12A ATP4A
9 acute laryngitis 10.7 ATP12A ATP4A
10 gastroduodenal crohn's disease 10.7 ATP12A ATP4A
11 gastric neuroendocrine neoplasm 10.7 ATP12A ATP4A
12 toxic megacolon 10.7 ATP12A ATP4A
13 aspiration pneumonitis 10.7 ATP12A ATP4A
14 postsurgical hypothyroidism 10.7 ATP12A ATP4A
15 gastric antral vascular ectasia 10.7 ATP12A ATP4A
16 esophageal candidiasis 10.6 ATP12A ATP4A
17 duodenitis 10.6 ATP12A ATP4A
18 bile reflux 10.6 ATP12A ATP4A
19 granulomatous gastritis 10.6 ATP12A ATP4A
20 active peptic ulcer disease 10.6 ATP12A ATP4A
21 laryngeal disease 10.6 ATP12A ATP4A
22 ischemic neuropathy 10.6 ATP12A ATP4A
23 capillary disease 10.6 ATP12A ATP4A
24 peptic esophagitis 10.5 ATP12A ATP4A
25 duodenal disease 10.5 ATP12A ATP4A
26 dyskinesia of esophagus 10.5 ATP12A ATP4A
27 lateral medullary syndrome 10.5 ATP12A ATP4A MRPS22
28 hernia, hiatus 10.5 ATP12A ATP4A
29 congenital disorder of deglycosylation 10.5 ATP12A ATP4A
30 superior mesenteric artery syndrome 10.4 ATP12A ATP4A HTR3A
31 esophageal atresia/tracheoesophageal fistula 10.4 ATP12A ATP4A
32 laryngitis 10.4 ATP12A ATP4A
33 laryngeal tuberculosis 10.3 ATP12A ATP4A
34 lymphocytic colitis 10.2 ATP12A ATP4A
35 rumination disorder 10.2 ATP12A ATP4A HTR3A HTR7
36 diarrhea 10.2
37 clostridium difficile colitis 10.1 ATP12A ATP4A
38 motion sickness 10.1 HTR3A HTR7 TAC1
39 glomangiosarcoma 10.1 DNTT TAC1
40 anismus 10.0 ATP12A ATP4A TAC1
41 aspiration pneumonia 10.0 ATP12A ATP4A TAC1
42 pain agnosia 10.0 HTR7 NTS TAC1
43 agnosia 10.0 HTR7 NTS TAC1
44 paine syndrome 10.0 ATP12A ATP4A TAC1
45 lower urinary tract calculus 9.9 ATP12A ATP4A
46 pylorospasm 9.8 GHRL HTR4
47 specific developmental disorder 9.7 GHRL HTR7 TAC1
48 functional gastric disease 9.5 ATP12A ATP4A GHRL HTR3A HTR7
49 aging 9.5
50 dyspepsia 9.5

Comorbidity relations with Functional Diarrhea via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Functional Diarrhea:



Diseases related to Functional Diarrhea

Symptoms & Phenotypes for Functional Diarrhea

UMLS symptoms related to Functional Diarrhea:


constipation, diarrhea, vomiting following gastrointestinal surgery

GenomeRNAi Phenotypes related to Functional Diarrhea according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 ATP4A CDH1 GHRL HTR4 NR1H4 PIK3C2A

MGI Mouse Phenotypes related to Functional Diarrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 GHRL HTR3A HTR4 HTR7 ITM2B NR1H4
2 growth/size/body region MP:0005378 9.93 ATP12A CDH1 CDK5RAP2 FGF19 GPBAR1 HTR3A
3 homeostasis/metabolism MP:0005376 9.83 ATP12A ATP4A CDH1 DNTT FGF19 GHRL
4 adipose tissue MP:0005375 9.8 GHRL GPBAR1 HTR4 NR1H4 NTS PIK3C2A
5 immune system MP:0005387 9.32 CDH1 CDK5RAP2 DNTT GPBAR1 HTR3A MMP1

Drugs & Therapeutics for Functional Diarrhea

Drugs for Functional Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 23)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loperamide Approved Phase 2, Phase 3 53179-11-6 3955
2
Baclofen Approved Phase 3 1134-47-0 2284
3
Desipramine Approved, Investigational Phase 3 50-47-5 2995
4 Gastrointestinal Agents Phase 2, Phase 3,Phase 1
5 Neurotransmitter Agents Phase 3,Phase 1
6 Antidiarrheals Phase 2, Phase 3
7 Adrenergic Agents Phase 3
8 Antidepressive Agents Phase 3
9 Antidepressive Agents, Tricyclic Phase 3
10 Neurotransmitter Uptake Inhibitors Phase 3
11 Proton Pump Inhibitors Phase 3
12 Psychotropic Drugs Phase 3
13
Citric Acid Approved, Nutraceutical, Vet_approved Phase 1 77-92-9 311
14 Mosapride Investigational Phase 1 112885-41-3
15 Anticoagulants Phase 1
16 Calcium, Dietary Phase 1
17 Chelating Agents Phase 1
18 Serotonin Agents Phase 1
19 Citrate Nutraceutical Phase 1
20
Serotonin Investigational, Nutraceutical Phase 1 50-67-9 5202
21 Acidophilus Nutraceutical Not Applicable
22 Bifidobacterium Nutraceutical Not Applicable
23 Cola Nutraceutical Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acupuncture for Patients With Diarrhea-predominant IBS or Functional Diarrhea: a Randomized Controlled Trial Completed NCT01350570 Phase 2, Phase 3 Loperamide
2 A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors Completed NCT01265550 Phase 3 baclofen;Desipramine
3 Trial for Quantity-Effect Relationship of Acupuncture With Two-ways Regulation to Treat Functional Enteropathy Unknown status NCT01274793 Phase 1 Mosapride Citrate tablet
4 Chronic Administration of Diosmectite (SMECTA®) in Subjects With Chronic Diarrhoea Completed NCT03045926 Phase 1 Diosmectite (Smecta®)
5 Efficacy of Probiotic Bacteria in Subjects With IBS or Functional Diarrhea/ Bloating Completed NCT00618904 Not Applicable
6 Gluten Intolerance in Patients With Diarrhea Predominant Irritable Bowel Syndrome Completed NCT01094041 Not Applicable

Search NIH Clinical Center for Functional Diarrhea

Genetic Tests for Functional Diarrhea

Anatomical Context for Functional Diarrhea

MalaCards organs/tissues related to Functional Diarrhea:

41
Colon

Publications for Functional Diarrhea

Articles related to Functional Diarrhea:

(show all 18)
# Title Authors Year
1
Analysis of Fecal Primary Bile Acids Detects Increased Stool Weight and Colonic Transit in Patients with Chronic Functional Diarrhea. ( 29902647 )
2018
2
The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study. ( 29684865 )
2018
3
Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity. ( 28573751 )
2017
4
Electroacupuncture for patients with diarrhea-predominant irritable bowel syndrome or functional diarrhea: A randomized controlled trial. ( 27310980 )
2016
5
Effects of electronically stimulating Tianshu (ST 25) and Dachangshu (BL 25), Quchi (LI 11) and Shangjuxu (ST 37) on the expressions of jejunum c-kit protein and c-kit mRNA in rats with functional diarrhea. ( 29949711 )
2016
6
Influence of acupuncture stimulation on cerebral network in functional diarrhea. ( 24459533 )
2013
7
Functional diarrhea. ( 22917168 )
2012
8
Epidemiology of functional diarrhea and comparison with diarrhea-predominant irritable bowel syndrome: a population-based survey in China. ( 22937091 )
2012
9
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. ( 17549631 )
2008
10
Treatment of functional diarrhea. ( 16836952 )
2006
11
Functional diarrhea. ( 16168232 )
2005
12
Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea. ( 11686387 )
2001
13
Inhibition of gastric secretion relieves diarrhea and postprandial urgency associated with irritable bowel syndrome or functional diarrhea. ( 10505731 )
1999
14
Rapid gastric emptying in patients with functional diarrhea. ( 9121178 )
1997
15
Colonic motility and functional diarrhea. ( 1622483 )
1992
16
Effect of eating on colonic motility and transit in patients with functional diarrhea. Simultaneous scintigraphic and manometric evaluations. ( 1936800 )
1991
17
Functional diarrhea: an analysis of the clinical and roentgen manifestations. ( 13397691 )
1956
18
Alterations in colonic function in man under stress; hypomotility of the sigmoid colon, and its relationship to the mechanism of functional diarrhea. ( 15421433 )
1950

Variations for Functional Diarrhea

Expression for Functional Diarrhea

Search GEO for disease gene expression data for Functional Diarrhea.

Pathways for Functional Diarrhea

Pathways related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.18 HTR3A HTR4 HTR7
2 10.54 FGF19 NR1H4
3 10.43 HTR4 HTR7
4 10.25 HTR3A HTR4 HTR7

GO Terms for Functional Diarrhea

Cellular components related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.26 GHRL HTR3A RAB11A TAC1
2 transport vesicle GO:0030133 8.8 NTS RAB11A TOR1A

Biological processes related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemical synaptic transmission GO:0007268 9.67 HTR3A HTR4 HTR7 TAC1
2 cellular sodium ion homeostasis GO:0006883 9.43 ATP12A ATP4A
3 cellular potassium ion homeostasis GO:0030007 9.4 ATP12A ATP4A
4 sodium ion export across plasma membrane GO:0036376 9.32 ATP12A ATP4A
5 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.26 ATP12A ATP4A
6 negative regulation of tumor necrosis factor secretion GO:1904468 9.16 GHRL NR1H4
7 positive regulation of adipose tissue development GO:1904179 8.96 GHRL NR1H4
8 negative regulation of bile acid biosynthetic process GO:0070858 8.62 FGF19 NR1H4

Molecular functions related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP12A ATP4A
2 serotonin binding GO:0051378 9.16 HTR3A HTR7
3 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A
4 bile acid receptor activity GO:0038181 8.62 GPBAR1 NR1H4

Sources for Functional Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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