MCID: FNC002
MIFTS: 40

Functional Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Functional Diarrhea

MalaCards integrated aliases for Functional Diarrhea:

Name: Functional Diarrhea 12 15 71
Functional Diarrhoea 12 32

Classifications:



External Ids:

Disease Ontology 12 DOID:11371
ICD9CM 34 564.5
SNOMED-CT 67 47812002
ICD10 32 K59.1
UMLS 71 C0156173

Summaries for Functional Diarrhea

MalaCards based summary : Functional Diarrhea, also known as functional diarrhoea, is related to diarrhea and lactose intolerance, and has symptoms including constipation, diarrhea and vomiting following gastrointestinal surgery. An important gene associated with Functional Diarrhea is FGF19 (Fibroblast Growth Factor 19), and among its related pathways/superpathways are Signaling by FGFR2 and Synthesis of bile acids and bile salts. The drugs Loperamide and Antidiarrheals have been mentioned in the context of this disorder. Affiliated tissues include colon, spleen and brain, and related phenotypes are growth/size/body region and digestive/alimentary

Related Diseases for Functional Diarrhea

Diseases related to Functional Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 141)
# Related Disease Score Top Affiliating Genes
1 diarrhea 30.3 SLC10A2 LCT KLB FGFR4 FGF19
2 lactose intolerance 29.3 LCT ATP4A ATP12A
3 microscopic colitis 29.2 ATP4A ATP12A
4 celiac disease 1 28.8 LCT ATP4A ATP12A
5 constipation 28.7 NPR3 FGFR4 FGF19 CLCN2 ATP4A ATP12A
6 irritable bowel syndrome 10.4
7 familial intrahepatic cholestasis 10.3 SLC10A2 NR1H4
8 anismus 10.2 NPR3 CLCN2
9 choline deficiency disease 10.2 NR1H4 GPBAR1
10 diarrhea, chronic, with villous atrophy 10.1
11 cholestasis, benign recurrent intrahepatic, 2 10.1 SLC10A2 NR1H4 CYP7A1
12 cholestasis, progressive familial intrahepatic, 3 10.1 SLC10A2 NR1H4 CYP7A1
13 cholestasis, progressive familial intrahepatic, 2 10.1 SLC10A2 NR1H4 CYP7A1
14 cholestasis, progressive familial intrahepatic, 1 10.1 SLC10A2 NR1H4 CYP7A1
15 progressive familial intrahepatic cholestasis 10.1 SLC10A2 NR1H4 CYP7A1
16 bile acid synthesis defect, congenital, 2 10.1 NR1H4 GPBAR1 CYP7A1
17 cholestasis, intrahepatic, of pregnancy, 1 10.1 SLC10A2 NR1H4
18 hypercholesterolemia, familial, 1 10.1 SLC10A2 NR1H4 CYP7A1
19 overgrowth syndrome 10.0
20 cholestasis, benign recurrent intrahepatic, 1 10.0 SLC10A2 NR1H4 FGF19 CYP7A1
21 heart defects, congenital, and other congenital anomalies 10.0 SLC10A2 NR1H4 GPBAR1 CYP7A1
22 cholestasis 10.0 SLC10A2 NR1H4 GPBAR1 CYP7A1
23 biliary tract disease 10.0 SLC10A2 NR1H4 GPBAR1 CYP7A1
24 hepatocellular clear cell carcinoma 9.9 NR1H4 KLB FGFR4 FGF19
25 extrahepatic cholestasis 9.9 NR1H4 FGFR4 FGF19 CYP7A1
26 vagus nerve disease 9.9 ATP4A ATP12A
27 necrotizing gastritis 9.9 ATP4A ATP12A
28 scalp dermatosis 9.9 ATP4A ATP12A
29 hemangioma of intra-abdominal structure 9.9 ATP4A ATP12A
30 acquired gastric outlet stenosis 9.9 ATP4A ATP12A
31 lingual goiter 9.9 ATP4A ATP12A
32 displacement of cardia through esophageal hiatus 9.9 ATP4A ATP12A
33 bacterial esophagitis 9.9 ATP4A ATP12A
34 cascade stomach 9.9 ATP4A ATP12A
35 benzylpenicillin allergy 9.9 ATP4A ATP12A
36 median arcuate ligament syndrome 9.9 ATP4A ATP12A
37 afferent loop syndrome 9.9 ATP4A ATP12A
38 cervix erosion 9.9 ATP4A ATP12A
39 angiodysplasia of intestine 9.9 ATP4A ATP12A
40 angiodysplasia 9.9 ATP4A ATP12A
41 granulomatous gastritis 9.9 ATP4A ATP12A
42 laryngeal tuberculosis 9.9 ATP4A ATP12A
43 fungal esophagitis 9.9 ATP4A ATP12A
44 dieulafoy lesion 9.9 ATP4A ATP12A
45 esophagus melanoma 9.9 ATP4A ATP12A
46 cefuroxime allergy 9.9 ATP4A ATP12A
47 emphysematous cholecystitis 9.8 ATP4A ATP12A
48 gastric gastrinoma 9.8 ATP4A ATP12A
49 superior mesenteric artery syndrome 9.8 ATP4A ATP12A
50 pneumatosis cystoides intestinalis 9.8 ATP4A ATP12A

Comorbidity relations with Functional Diarrhea via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Functional Diarrhea:



Diseases related to Functional Diarrhea

Symptoms & Phenotypes for Functional Diarrhea

UMLS symptoms related to Functional Diarrhea:


constipation, diarrhea, vomiting following gastrointestinal surgery

MGI Mouse Phenotypes related to Functional Diarrhea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.65 ATP12A ATP4A CYP7A1 FGF19 FGFR4 GPBAR1
2 digestive/alimentary MP:0005381 9.63 ATP12A ATP4A CLCN2 CYP7A1 NR1H4 SLC10A2
3 homeostasis/metabolism MP:0005376 9.36 ATP12A ATP4A CLCN2 CYP7A1 FGFR4 GPBAR1

Drugs & Therapeutics for Functional Diarrhea

Drugs for Functional Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loperamide Approved Phase 2, Phase 3 53179-11-6 3955
2 Antidiarrheals Phase 2, Phase 3
3 Gastrointestinal Agents Phase 2, Phase 3
4
Sodium citrate Approved, Investigational Phase 1 68-04-2
5
Citric acid Approved, Nutraceutical, Vet_approved Phase 1 77-92-9 311
6 Mosapride Investigational Phase 1 112885-41-3
7 Citrate Phase 1
8 Serotonin Receptor Agonists Phase 1
9 Neurotransmitter Agents Phase 1
10
Serotonin Investigational, Nutraceutical Phase 1 50-67-9 5202
11 Acidophilus
12 Bifidobacterium

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Crofelemer for Functional Diarrhea Recruiting NCT04486326 Phase 4 Crofelemer;Placebo
2 Acupuncture for Functional Bowel Disease Completed NCT01350570 Phase 2, Phase 3 Loperamide
3 Multicentre Randomized Controlled Trial for Quantity-Effect Relationship of Acupuncture With Two-ways Regulation to Treat Functional Enteropathy Unknown status NCT01274793 Phase 1 Mosapride Citrate tablet
4 Assessment of Elemental Impurities Level After Chronic Administration of Diosmectite (SMECTA®) in Subjects With Chronic Diarrhoea Completed NCT03045926 Phase 1 Diosmectite (Smecta®)
5 Clinical Efficacy of Probiotic Bacteria in Subjects With Irritable Bowel Syndrome (IBS), Functional Diarrhea, or Functional Bloating Completed NCT00618904

Search NIH Clinical Center for Functional Diarrhea

Genetic Tests for Functional Diarrhea

Anatomical Context for Functional Diarrhea

MalaCards organs/tissues related to Functional Diarrhea:

40
Colon, Spleen, Brain, Small Intestine, Thyroid, Hypothalamus

Publications for Functional Diarrhea

Articles related to Functional Diarrhea:

(show top 50) (show all 220)
# Title Authors PMID Year
1
The Epidemiology and Quality of Life of Functional Gastrointestinal Disorders According to Rome III vs Rome IV Criteria: A Cross-sectional Study in Primary Care. 61
33595169 2021
2
Personality of patients with fecal incontinence. 61
33000298 2021
3
Prevalence and clinical features of bile acid diarrhea in patients with chronic diarrhea. 61
33438795 2021
4
The association of body mass index with functional dyspepsia is independent of psychological morbidity: A cross-sectional study. 61
33497382 2021
5
Making the Diagnosis of Bile Acid Diarrhea. 61
33269891 2020
6
Lactose sensitivity and lactose malabsorption. The two faces of lactose intolerance. 61
33361550 2020
7
Prevalence, overlap, and risk factors for Rome IV functional gastrointestinal disorders among college students in northern India. 61
33226570 2020
8
Prevalence and Associated Dietary Factors of Rome IV Functional Gastrointestinal Disorders in Rural Western Honduras. 61
33089482 2020
9
The Role of Bile Acids in Chronic Diarrhea. 61
32558690 2020
10
Diagnostic Yield of Colonoscopy in Patients With Symptoms Compatible With Rome IV Functional Bowel Disorders. 61
32882424 2020
11
High prevalence of primary bile acid diarrhoea in patients with functional diarrhoea and irritable bowel syndrome-diarrhoea, based on Rome III and Rome IV criteria. 61
32954237 2020
12
Cohort Profile: The Christchurch IBS cOhort to investigate Mechanisms FOr gut Relief and improved Transit (COMFORT). 61
32999886 2020
13
Diagnostic approach to chronic diarrhoea and recent insights in treatment of functional diarrhoea including irritable bowel syndrome. 61
33094595 2020
14
Shenling Baizhu Powder () Ameliorates Pi (Spleen)-Deficiency-Induced Functional Diarrhea in Rats. 61
32720115 2020
15
Chronic Diarrhea in Adults: Evaluation and Differential Diagnosis. 61
32293842 2020
16
Prevalence of Rome IV Functional Bowel Disorders Among Adults in the United States, Canada, and the United Kingdom. 61
31917991 2020
17
Role of a berberine-based nutritional supplement in reducing diarrhea in subjects with functional gastrointestinal disorders. 61
32283882 2020
18
Epidemiological, Clinical, and Psychological Characteristics of Individuals with Self-reported Irritable Bowel Syndrome Based on the Rome IV vs Rome III Criteria. 61
31154027 2020
19
Canadian Association of Gastroenterology Clinical Practice Guideline on the Management of Bile Acid Diarrhea. 61
32010878 2020
20
Similarities in Clinical and Psychosocial Characteristics of Functional Diarrhea and Irritable Bowel Syndrome With Diarrhea. 61
31442602 2020
21
Increasing Evidence That Irritable Bowel Syndrome and Functional Gastrointestinal Disorders Have a Microbial Pathogenesis. 61
33014892 2020
22
Data Mining Approach for the Characterization of Functional Bowel Disorders According to Symptom Intensity Provides a Small Number of Homogenous Groups. 61
31775138 2020
23
Diagnosis and management of bile acid diarrhoea: a survey of UK expert opinion and practice. 61
32879719 2020
24
Acupuncture for Adults with Diarrhea-Predominant Irritable Bowel Syndrome or Functional Diarrhea: A Systematic Review and Meta-Analysis. 61
33299403 2020
25
Canadian Association of Gastroenterology Clinical Practice Guideline on the Management of Bile Acid Diarrhea. 61
31526844 2020
26
Susceptibility to diarrhea is related to hemodynamic markers of sympathetic activation in the general population. 61
31791149 2019
27
What's in the pipeline for lower functional gastrointestinal disorders in the next 5 years? 61
31460793 2019
28
Highlights of the AGA Technical Review on Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome. 61
31787857 2019
29
AGA Clinical Practice Guidelines on the Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D): Patient Summary. 61
31378676 2019
30
Spotlight: Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D). 61
31377275 2019
31
AGA Clinical Practice Guidelines on the Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D). 61
31302098 2019
32
Neonatal Antibiotics and Prematurity Are Associated with an Increased Risk of Functional Gastrointestinal Disorders in the First Year of Life. 61
31201028 2019
33
AGA Technical Review on the Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D). 61
31351880 2019
34
Use of Bioelectronics in the Gastrointestinal Tract. 61
30249600 2019
35
Chronic Diarrhea Evaluation in the Elderly: IBS or Something Else? 61
31346793 2019
36
[Electroacupuncture improves intestinal function by down-regulating expression of 5-HT1AR and c-fos proteins in the hypothalamus and colon tissues via brain-gut axis in rats with functional diarrhea]. 61
31368281 2019
37
[Zaburzenia czynnoĹ›ciowe przewodu pokarmowego u osób z przerostem bakteryjnym jelita cienkiego]. 61
31260431 2019
38
Analysis of Fecal Primary Bile Acids Detects Increased Stool Weight and Colonic Transit in Patients With Chronic Functional Diarrhea. 61
29902647 2019
39
Rebamipide increases the disaccharidases activity in patients with enteropathy with impaired membrane digestion. Pilot study. 61
31094168 2019
40
Risk factors for upper and lower functional gastrointestinal disorders in Persian Gulf War Veterans during and post-deployment. 61
30697884 2019
41
Adverse drug reactions of Yunnan Baiyao capsule: a multi-center intensive monitoring study in China. 61
31032273 2019
42
Beneficial effects of Saccharomyces boulardii CNCM I-745 on clinical disorders associated with intestinal barrier disruption. 61
30804678 2019
43
Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder. 61
30350113 2019
44
The Relation between Dietary Patterns and Functional Gastrointestinal Disorders among Iranian Military Men. 61
30775344 2019
45
Clinical and psychological correlates of soiling in adult patients with functional gastrointestinal disorders. 61
29987361 2018
46
The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study. 61
29684865 2018
47
Multicenter observational study on functional bowel disorders diagnosed using Rome III diagnostic criteria in Japan. 61
29305648 2018
48
Association Between Ultra-Processed Food Consumption and Functional Gastrointestinal Disorders: Results From the French NutriNet-Santé Cohort. 61
29904158 2018
49
[Nutritional management of functional chronic diarrhea associated to malnutrition with peptide diet: a case report]. 61
29974788 2018
50
Functional Gastrointestinal Disorders: Functional Gastrointestinal Disorders in Children. 61
29528207 2018

Variations for Functional Diarrhea

Expression for Functional Diarrhea

Search GEO for disease gene expression data for Functional Diarrhea.

Pathways for Functional Diarrhea

GO Terms for Functional Diarrhea

Cellular components related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of membrane GO:0016021 9.65 SLC10A2 NPR3 LCT KLB GPBAR1 FGFR4
2 receptor complex GO:0043235 9.33 NR1H4 GPBAR1 FGFR4
3 integral component of plasma membrane GO:0005887 9.1 SLC10A2 NPR3 LCT FGFR4 CLCN2 ATP4A

Biological processes related to Functional Diarrhea according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 ion transport GO:0006811 9.72 SLC10A2 PDZD3 CLCN2 ATP4A ATP12A
2 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.7 GPBAR1 FGFR4 FGF19
3 positive regulation of protein kinase B signaling GO:0051897 9.69 KLB FGFR4 FGF19
4 cholesterol homeostasis GO:0042632 9.54 NR1H4 FGFR4 CYP7A1
5 cellular sodium ion homeostasis GO:0006883 9.49 ATP4A ATP12A
6 sodium ion export across plasma membrane GO:0036376 9.48 ATP4A ATP12A
7 cellular potassium ion homeostasis GO:0030007 9.46 ATP4A ATP12A
8 bile acid signaling pathway GO:0038183 9.43 NR1H4 CYP7A1
9 fibroblast growth factor receptor signaling pathway GO:0008543 9.43 KLB FGFR4 FGF19
10 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.4 ATP4A ATP12A
11 cellular response to bile acid GO:1903413 9.16 NR1H4 GPBAR1
12 bile acid and bile salt transport GO:0015721 9.13 SLC10A2 NR1H4 CYP7A1
13 regulation of bile acid biosynthetic process GO:0070857 8.8 NR1H4 FGFR4 CYP7A1

Molecular functions related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hydrolase activity, hydrolyzing O-glycosyl compounds GO:0004553 9.4 LCT KLB
2 fibroblast growth factor receptor binding GO:0005104 9.37 KLB FGF19
3 fibroblast growth factor binding GO:0017134 9.32 KLB FGFR4
4 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
5 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
6 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A
7 bile acid receptor activity GO:0038181 8.62 NR1H4 GPBAR1

Sources for Functional Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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