MCID: FNC002
MIFTS: 40

Functional Diarrhea

Categories: Gastrointestinal diseases
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Aliases & Classifications for Functional Diarrhea

MalaCards integrated aliases for Functional Diarrhea:

Name: Functional Diarrhea 11 14 71
Functional Diarrhoea 11 31 33

Classifications:



External Ids:

Disease Ontology 11 DOID:11371
ICD9CM 34 564.5
SNOMED-CT 68 47812002
ICD10 31 K59.1
ICD11 33 1150846989
UMLS 71 C0156173

Summaries for Functional Diarrhea

MalaCards based summary: Functional Diarrhea, also known as functional diarrhoea, is related to diarrhea and lactose intolerance, and has symptoms including constipation, diarrhea and vomiting following gastrointestinal surgery. An important gene associated with Functional Diarrhea is FGF19 (Fibroblast Growth Factor 19), and among its related pathways/superpathways are Signaling by FGFR2 and Synthesis of bile acids and bile salts. The drugs Loperamide and Gastrointestinal Agents have been mentioned in the context of this disorder. Affiliated tissues include colon, small intestine and hypothalamus, and related phenotypes are homeostasis/metabolism and growth/size/body region

Related Diseases for Functional Diarrhea

Diseases related to Functional Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 176)
# Related Disease Score Top Affiliating Genes
1 diarrhea 30.3 SLC10A2 MLN KLB FGFR4 FGF19
2 lactose intolerance 29.9 ATP4A ATP12A
3 microscopic colitis 29.7 FGF19 ATP4A ATP12A
4 ischemic colitis 29.7 NPR3 ATP4A ATP12A
5 gastroesophageal reflux 29.5 MLN ATP4A ATP12A
6 irritable bowel syndrome 10.4
7 epilepsy, idiopathic generalized 4 10.3 KLB FGF19
8 postcholecystectomy syndrome 10.3 MLN FGF19
9 pancreatic vasoactive intestinal peptide producing tumor 10.2 ATP4A ATP12A
10 acquired laryngomalacia 10.2 ATP4A ATP12A
11 laryngomalacia 10.2 ATP4A ATP12A
12 scalp dermatosis 10.2 ATP4A ATP12A
13 acquired gastric outlet stenosis 10.2 ATP4A ATP12A
14 lingual goiter 10.2 ATP4A ATP12A
15 esophageal diverticulosis 10.2 ATP4A ATP12A
16 displacement of cardia through esophageal hiatus 10.2 ATP4A ATP12A
17 benign shuddering attacks 10.2 ATP4A ATP12A
18 persistent moderate asthma 10.2 ATP4A ATP12A
19 viral esophagitis 10.2 ATP4A ATP12A
20 cervix erosion 10.2 ATP4A ATP12A
21 bacterial esophagitis 10.2 ATP4A ATP12A
22 chronic duodenal ileus 10.2 ATP4A ATP12A
23 angiodysplasia of intestine 10.2 ATP4A ATP12A
24 angiodysplasia 10.2 ATP4A ATP12A
25 benzylpenicillin allergy 10.2 ATP4A ATP12A
26 penicillin allergy 10.2 ATP4A ATP12A
27 granulomatous gastritis 10.2 ATP4A ATP12A
28 fungal gastritis 10.2 ATP4A ATP12A
29 fungal esophagitis 10.2 ATP4A ATP12A
30 esophagus melanoma 10.2 ATP4A ATP12A
31 emphysematous cholecystitis 10.2 ATP4A ATP12A
32 afferent loop syndrome 10.2 ATP4A ATP12A
33 laryngeal tuberculosis 10.2 ATP4A ATP12A
34 gastrojejunal ulcer 10.2 ATP4A ATP12A
35 cefuroxime allergy 10.2 ATP4A ATP12A
36 median arcuate ligament syndrome 10.2 ATP4A ATP12A
37 bacterial gastritis 10.2 ATP4A ATP12A
38 dieulafoy lesion 10.2 ATP4A ATP12A
39 hypopigmentation of eyelid 10.2 ATP4A ATP12A
40 gastric gastrinoma 10.2 ATP4A ATP12A
41 lymphocytic gastritis 10.2 ATP4A ATP12A
42 central nervous system origin vertigo 10.2 ATP4A ATP12A
43 chronic laryngitis 10.2 ATP4A ATP12A
44 laryngitis 10.2 ATP4A ATP12A
45 internal hemorrhoid 10.2 ATP4A ATP12A
46 hemorrhoid 10.2 ATP4A ATP12A
47 chronic intestinal vascular insufficiency 10.2 ATP4A ATP12A
48 peptic ulcer perforation 10.2 ATP4A ATP12A
49 splenic artery aneurysm 10.2 ATP4A ATP12A
50 cascade stomach 10.2 ATP4A ATP12A

Comorbidity relations with Functional Diarrhea via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Functional Diarrhea:



Diseases related to Functional Diarrhea

Symptoms & Phenotypes for Functional Diarrhea

UMLS symptoms related to Functional Diarrhea:


constipation; diarrhea; vomiting following gastrointestinal surgery

MGI Mouse Phenotypes related to Functional Diarrhea:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.03 ATP12A ATP4A CLCN2 CYP7A1 FGF19 FGFR4
2 growth/size/body region MP:0005378 9.85 ATP12A ATP4A CYP7A1 FGF19 FGFR4 GPBAR1
3 digestive/alimentary MP:0005381 9.43 ATP12A ATP4A CLCN2 CYP7A1 NR1H4 SLC10A2
4 cardiovascular system MP:0005385 9.23 CLCN2 CYP7A1 FGF19 GPBAR1 KLB NPR3

Drugs & Therapeutics for Functional Diarrhea

Drugs for Functional Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loperamide Approved Phase 2, Phase 3 53179-11-6 3955
2 Gastrointestinal Agents Phase 2, Phase 3
3 Antidiarrheals Phase 2, Phase 3
4 Bile Acids and Salts Phase 2
5 Pharmaceutical Solutions Phase 2
6
Sodium citrate Approved, Investigational Phase 1 68-04-2 23431961
7
Citric acid Approved, Nutraceutical, Vet_approved Phase 1 77-92-9 311
8
Mosapride Investigational Phase 1 112885-41-3 119584
9 Neurotransmitter Agents Phase 1
10 Serotonin Receptor Agonists Phase 1
11 Citrate Phase 1
12
Serotonin Investigational, Nutraceutical Phase 1 50-67-9 5202
13 Bifidobacterium
14 Acidophilus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Crofelemer for Functional Diarrhea Unknown status NCT04486326 Phase 4 Crofelemer;Placebo
2 Acupuncture for Functional Bowel Disease Completed NCT01350570 Phase 2, Phase 3 Loperamide
3 A Randomized, Double-Blind, Placebo Controlled Trial of Aldafermin (NGM282) for Treatment of Chronic Diarrhea Due to Bile Acid Malabsorption (BAM) Recruiting NCT05130047 Phase 2 Aldafermin;Placebo
4 Multicentre Randomized Controlled Trial for Quantity-Effect Relationship of Acupuncture With Two-ways Regulation to Treat Functional Enteropathy Unknown status NCT01274793 Phase 1 Mosapride Citrate tablet
5 Assessment of Elemental Impurities Level After Chronic Administration of Diosmectite (SMECTA®) in Subjects With Chronic Diarrhoea Completed NCT03045926 Phase 1 Diosmectite (Smecta®)
6 A Feasibility Study on Different Health Education Delivery Methods for a Low Fermentable Carbohydrate (FODMAP) Diet in Patients With Functional Bowel Disorders Completed NCT03694223
7 Clinical Efficacy of Probiotic Bacteria in Subjects With Irritable Bowel Syndrome (IBS), Functional Diarrhea, or Functional Bloating Completed NCT00618904

Search NIH Clinical Center for Functional Diarrhea

Genetic Tests for Functional Diarrhea

Anatomical Context for Functional Diarrhea

Organs/tissues related to Functional Diarrhea:

MalaCards : Colon, Small Intestine, Hypothalamus, Spleen, Thyroid, Brain

Publications for Functional Diarrhea

Articles related to Functional Diarrhea:

(show top 50) (show all 257)
# Title Authors PMID Year
1
Latent class analysis does not support the existence of Rome IV functional bowel disorders as discrete entities. 62
35531932 2022
2
Current and Future Therapeutic Options for Irritable Bowel Syndrome with Diarrhea and Functional Diarrhea. 62
36376576 2022
3
Endoscopic laser endomicroscopy and "leaky gut" in patients with functional gastrointestinal symptoms and food intolerance. 62
36417920 2022
4
Long-term Gastrointestinal Sequelae Following COVID-19: A Prospective Follow-up Cohort Study. 62
36273799 2022
5
Role of Calcitonin Gene-Related Peptide on the Gastrointestinal Symptoms of Migraine-Clinical Considerations: A Narrative Review. 62
36127137 2022
6
Economic living standard and abdominal pain mediate the association between functional gastrointestinal disorders and depression or anxiety. 62
36153804 2022
7
A study on the effect of symbiotic fermented milk products on human gastrointestinal health: Double-blind randomized controlled clinical trial. 62
36171774 2022
8
Prematurity and functional gastrointestinal disorders in infancy: a cross-sectional study. 62
35648986 2022
9
Prevalence of Functional Gastrointestinal Disorders in Brazilian Infants Seen in Private Pediatric Practices and Their Associated Factors. 62
35622063 2022
10
Functional bowel disorders with diarrhoea: Clinical guidelines of the United European Gastroenterology and European Society for Neurogastroenterology and Motility. 62
35695704 2022
11
Influencing Mechanism of Cupping Moxibustion on Gastrointestinal Function and Immune Function in Patients with Functional Diarrhea. 62
36227672 2022
12
Increased Fecal Bile Acid Excretion in a Significant Subset of Patients with Other Inflammatory Diarrheal Diseases. 62
33886031 2022
13
Colonic bacterial diversity and dysbiosis in active microscopic colitis as compared to chronic diarrhoea and healthy controls: effect of polyethylene glycol after bowel lavage for colonoscopy. 62
35764931 2022
14
Characteristics of, and natural history among, individuals with Rome IV functional bowel disorders. 62
34532930 2022
15
Pathophysiology and Clinical Management of Bile Acid Diarrhea. 62
35683489 2022
16
Functional gastrointestinal disorders frequency by Rome IV criteria. 62
35534416 2022
17
Improvement in constipation and diarrhea is associated with improved abdominal pain in patients with functional bowel disorders. 62
34520617 2022
18
Diagnostic Yield of Colonoscopy in Patients With Symptoms Compatible With Rome IV Functional Bowel Disorders. 62
32882424 2022
19
Long-term diosmectite use does not alter the gut microbiota in adults with chronic diarrhea. 62
35151268 2022
20
Current Treatment Options and Therapeutic Insights for Gastrointestinal Dysmotility and Functional Gastrointestinal Disorders. 62
35145413 2022
21
Abdominal massage alleviates functional diarrhea in immature rats via modulation of intestinal microbiota and tight junction protein. 62
35935373 2022
22
Mucosal healing and quality of life in therapeutic goals of ulcerative colitis: occurrence and related factors of functional bowel disorder-like symptoms. 62
35509421 2022
23
A Randomized, Double-Blind, Placebo-Controlled Trial to Assess the Efficacy and Safety of Lactiplantibacillus plantarum CJLP243 in Patients with Functional Diarrhea and High Fecal Calprotectin Levels. 62
35057571 2022
24
The Effect of Electroacupuncture Treatment with Different Intensities for Functional Diarrhea: A Randomized Controlled Trial. 62
35027932 2022
25
The effectiveness of herbal acupoint application for functional diarrhea: Protocol for a meta-analysis and data mining. 62
34964730 2021
26
Increased psychological distress and somatization in patients with irritable bowel syndrome compared with functional diarrhea or functional constipation, based on Rome IV criteria. 62
33719130 2021
27
Concentrations of Fecal Bile Acids in Participants with Functional Gut Disorders and Healthy Controls. 62
34564428 2021
28
Prevalence and Associated Dietary Factors of Rome IV Functional Gastrointestinal Disorders in Rural Western Honduras. 62
33089482 2021
29
Abdominal Pain and Depression, Not Bowel Habits, Predict Health Care Utilization in Patients With Functional Bowel Disorders. 62
34003175 2021
30
[Effect of electroacupuncture on 5-HT7R in gastric antrum and colon tissues of functional diarrhea rats]. 62
34369673 2021
31
Patients with functional bowel disorder have disaccharidase deficiency: A single-center study from Russia. 62
34141780 2021
32
[Functional gastrointestinal disorders frequency by Rome IV criteria]. 62
34217673 2021
33
Effect of electroacupuncture on chemotherapy-induced diarrhea: study protocol for a randomized controlled trial. 62
35116567 2021
34
The Role of Purported Mucoprotectants in Dealing with Irritable Bowel Syndrome, Functional Diarrhea, and Other Chronic Diarrheal Disorders in Adults. 62
33738725 2021
35
Lactose Sensitivity and Lactose Malabsorption: The 2 Faces of Lactose Intolerance. 62
33361550 2021
36
Prevalence, overlap, and risk factors for Rome IV functional gastrointestinal disorders among college students in northern India. 62
33226570 2021
37
The epidemiology and quality of life of functional gastrointestinal disorders according to Rome III vs Rome IV criteria: A cross-sectional study in primary care. 62
33595169 2021
38
Diagnosis and Treatment of Irritable Bowel Syndrome: A Review. 62
33651094 2021
39
Shenling Baizhu Powder () Ameliorates Pi (Spleen)-Deficiency-Induced Functional Diarrhea in Rats. 62
32720115 2021
40
Prevalence and clinical features of bile acid diarrhea in patients with chronic diarrhea. 62
33438795 2021
41
Personality of patients with fecal incontinence. 62
33000298 2021
42
The association of body mass index with functional dyspepsia is independent of psychological morbidity: A cross-sectional study. 62
33497382 2021
43
Early life antibiotics and childhood gastrointestinal disorders: a systematic review. 62
33748435 2021
44
Information retrieval strategy in functional gastrointestinal disorders with emphasis on the sensitivity and precision. 62
34395644 2021
45
Lactobacillus plantarum CCFM1143 Alleviates Chronic Diarrhea via Inflammation Regulation and Gut Microbiota Modulation: A Double-Blind, Randomized, Placebo-Controlled Study. 62
34721416 2021
46
Making the Diagnosis of Bile Acid Diarrhea. 62
33269891 2020
47
The Role of Bile Acids in Chronic Diarrhea. 62
32558690 2020
48
High prevalence of primary bile acid diarrhoea in patients with functional diarrhoea and irritable bowel syndrome-diarrhoea, based on Rome III and Rome IV criteria. 62
32954237 2020
49
Cohort Profile: The Christchurch IBS cOhort to investigate Mechanisms FOr gut Relief and improved Transit (COMFORT). 62
32999886 2020
50
Diagnostic approach to chronic diarrhoea and recent insights in treatment of functional diarrhoea including irritable bowel syndrome. 62
33094595 2020

Variations for Functional Diarrhea

Expression for Functional Diarrhea

Search GEO for disease gene expression data for Functional Diarrhea.

GO Terms for Functional Diarrhea

Cellular components related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016021 9.91 SLC10A2 NPR3 KLB GPBAR1 FGFR4 CYP7A1
2 membrane GO:0016020 9.91 SLC10A2 NPR3 KLB GPBAR1 FGFR4 CYP7A1
3 plasma membrane GO:0005886 9.58 SLC10A2 NPR3 GPBAR1 FGFR4 CLCN2 ATP4A
4 plasma membrane GO:0005887 9.58 SLC10A2 NPR3 GPBAR1 FGFR4 CLCN2 ATP4A

Biological processes related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholesterol homeostasis GO:0042632 9.91 NR1H4 FGFR4 CYP7A1
2 fibroblast growth factor receptor signaling pathway GO:0008543 9.8 FGF19 FGFR4 KLB
3 sodium ion export across plasma membrane GO:0036376 9.78 ATP4A ATP12A
4 cellular potassium ion homeostasis GO:0030007 9.76 ATP4A ATP12A
5 monoatomic ion transport GO:0006811 9.73 SLC10A2 NHERF4 CLCN2 ATP4A ATP12A
6 bile acid signaling pathway GO:0038183 9.71 NR1H4 CYP7A1
7 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.67 ATP4A ATP12A
8 cellular response to bile acid GO:1903413 9.46 NR1H4 GPBAR1
9 bile acid and bile salt transport GO:0015721 9.43 SLC10A2 FGF19 CYP7A1
10 regulation of bile acid biosynthetic process GO:0070857 9.1 NR1H4 FGFR4 CYP7A1

Molecular functions related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 P-type sodium:potassium-exchanging transporter activity GO:0005391 9.56 ATP4A ATP12A
2 P-type potassium:proton transporter activity GO:0008900 9.26 ATP4A ATP12A
3 P-type potassium transmembrane transporter activity GO:0008556 9.16 ATP4A ATP12A
4 bile acid receptor activity GO:0038181 8.92 NR1H4 GPBAR1

Sources for Functional Diarrhea

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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