MCID: FNC002
MIFTS: 39

Functional Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Functional Diarrhea

MalaCards integrated aliases for Functional Diarrhea:

Name: Functional Diarrhea 12 15 71

Classifications:



External Ids:

Disease Ontology 12 DOID:11371
ICD9CM 34 564.5
SNOMED-CT 67 47812002
ICD10 32 K59.1
UMLS 71 C0156173

Summaries for Functional Diarrhea

MalaCards based summary : Functional Diarrhea is related to diarrhea and ischemic colitis, and has symptoms including constipation, diarrhea and vomiting following gastrointestinal surgery. An important gene associated with Functional Diarrhea is FGF19 (Fibroblast Growth Factor 19), and among its related pathways/superpathways are Ion channel transport and Signaling by FGFR2. The drugs Loperamide and Clonidine have been mentioned in the context of this disorder. Affiliated tissues include colon, testes and small intestine, and related phenotypes are growth/size/body region and digestive/alimentary

Related Diseases for Functional Diarrhea

Diseases related to Functional Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 132)
# Related Disease Score Top Affiliating Genes
1 diarrhea 31.1 SLC10A2 HTR3A FGF19
2 ischemic colitis 29.8 NPR3 HTR3A
3 lymphocytic colitis 29.1 ATP4A ATP12A
4 microscopic colitis 29.0 ATP4A ATP12A
5 constipation 27.7 NPR3 HTR3A FGFR4 FGF19 CLCN2 ATP4A
6 familial intrahepatic cholestasis 10.4 SLC10A2 NR1H4
7 anismus 10.3 NPR3 CLCN2
8 cholestasis, progressive familial intrahepatic, 3 10.3 SLC10A2 NR1H4
9 irritable bowel syndrome 10.3
10 bile acid synthesis defect, congenital, 3 10.2 NR1H4 CYP7A1
11 cholestasis, intrahepatic, of pregnancy, 1 10.1 SLC10A2 NR1H4
12 cholestasis, benign recurrent intrahepatic, 2 10.0 SLC10A2 NR1H4 CYP7A1
13 cholestasis, progressive familial intrahepatic, 2 10.0 SLC10A2 NR1H4 CYP7A1
14 cholestasis, progressive familial intrahepatic, 1 10.0 SLC10A2 NR1H4 CYP7A1
15 progressive familial intrahepatic cholestasis 10.0 SLC10A2 NR1H4 CYP7A1
16 cholestasis, benign recurrent intrahepatic, 1 10.0 SLC10A2 NR1H4 CYP7A1
17 bile acid synthesis defect, congenital, 2 10.0 NR1H4 GPBAR1 CYP7A1
18 autoimmune disease of urogenital tract 10.0 NR1H4 GPBAR1 CYP7A1
19 overgrowth syndrome 9.9
20 pancreatic vasoactive intestinal peptide producing tumor 9.9 ATP4A ATP12A
21 hemangioma of intra-abdominal structure 9.9 ATP4A ATP12A
22 secretory diarrhea 9.9 PDZD3 NPR3
23 displacement of cardia through esophageal hiatus 9.9 ATP4A ATP12A
24 gastric hemangioma 9.9 ATP4A ATP12A
25 acquired gastric outlet stenosis 9.9 ATP4A ATP12A
26 angiodysplasia of intestine 9.9 ATP4A ATP12A
27 angiodysplasia 9.9 ATP4A ATP12A
28 benzylpenicillin allergy 9.9 ATP4A ATP12A
29 median arcuate ligament syndrome 9.9 ATP4A ATP12A
30 granulomatous gastritis 9.9 ATP4A ATP12A
31 bacterial esophagitis 9.9 ATP4A ATP12A
32 lingual goiter 9.9 ATP4A ATP12A
33 cascade stomach 9.9 ATP4A ATP12A
34 gastrojejunal ulcer 9.9 ATP4A ATP12A
35 fungal esophagitis 9.9 ATP4A ATP12A
36 gastric gastrinoma 9.9 ATP4A ATP12A
37 fungal gastritis 9.9 ATP4A ATP12A
38 superior mesenteric artery syndrome 9.9 ATP4A ATP12A
39 cervix erosion 9.9 ATP4A ATP12A
40 pneumatosis cystoides intestinalis 9.9 ATP4A ATP12A
41 dieulafoy lesion 9.9 ATP4A ATP12A
42 esophagus sarcoma 9.9 ATP4A ATP12A
43 esophagus melanoma 9.9 ATP4A ATP12A
44 polyposis, skin pigmentation, alopecia, and fingernail changes 9.8 ATP4A ATP12A
45 necrotizing gastritis 9.8 ATP4A ATP12A
46 central nervous system origin vertigo 9.8 ATP4A ATP12A
47 chronic laryngitis 9.8 ATP4A ATP12A
48 laryngitis 9.8 ATP4A ATP12A
49 cefuroxime allergy 9.8 ATP4A ATP12A
50 gastroduodenitis 9.8 ATP4A ATP12A

Comorbidity relations with Functional Diarrhea via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Functional Diarrhea:



Diseases related to Functional Diarrhea

Symptoms & Phenotypes for Functional Diarrhea

UMLS symptoms related to Functional Diarrhea:


constipation, diarrhea, vomiting following gastrointestinal surgery

MGI Mouse Phenotypes related to Functional Diarrhea:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.85 ATP12A CYP7A1 FGF19 FGFR4 GPBAR1 HTR3A
2 digestive/alimentary MP:0005381 9.8 ATP12A ATP4A CLCN2 CYP7A1 NR1H4 SLC10A2
3 endocrine/exocrine gland MP:0005379 9.8 ATP4A CLCN2 FGF19 GPBAR1 HTR3A KLB
4 homeostasis/metabolism MP:0005376 9.77 ATP12A ATP4A CLCN2 CYP7A1 FGF19 FGFR4
5 immune system MP:0005387 9.23 ATP4A CLCN2 CYP7A1 FGFR4 GPBAR1 HTR3A

Drugs & Therapeutics for Functional Diarrhea

Drugs for Functional Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 32)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loperamide Approved Phase 2, Phase 3 53179-11-6 3955
2
Clonidine Approved Phase 3 4205-90-7 2803
3 Gastrointestinal Agents Phase 2, Phase 3
4 Antidiarrheals Phase 2, Phase 3
5 Neurotransmitter Agents Phase 3
6 Analgesics Phase 3
7 Antihypertensive Agents Phase 3
8 Adrenergic Agonists Phase 3
9 Adrenergic alpha-2 Receptor Agonists Phase 3
10 Anticholesteremic Agents Phase 3
11 Hypolipidemic Agents Phase 3
12 Autonomic Agents Phase 3
13 Bile Acids and Salts Phase 3
14 Colesevelam Hydrochloride Phase 3
15 Sympatholytics Phase 3
16 Antimetabolites Phase 3
17 Lipid Regulating Agents Phase 3
18 Adrenergic Agents Phase 3
19 Cola Phase 2
20
Sodium citrate Approved, Investigational Phase 1 68-04-2
21
Citric acid Approved, Nutraceutical, Vet_approved Phase 1 77-92-9 311
22
Calcium Approved, Nutraceutical Phase 1 7440-70-2 271
23 Mosapride Investigational Phase 1 112885-41-3
24 Citrate Phase 1
25 Chelating Agents Phase 1
26 Anticoagulants Phase 1
27 Serotonin Agents Phase 1
28 Calcium, Dietary Phase 1
29 Serotonin Receptor Agonists Phase 1
30
Serotonin Investigational, Nutraceutical Phase 1 50-67-9 5202
31 Acidophilus
32 Bifidobacterium

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acupuncture for Functional Bowel Disease Completed NCT01350570 Phase 2, Phase 3 Loperamide
2 A Placebo Controlled Study of Colesevelam in Fecal Incontinence Recruiting NCT02628626 Phase 3 Colesevelam;Clonidine
3 A Phase IIB Study to Evaluate the Effects of Welchol (Colesevelam Hydrochloride) on Colonic Transit, Intestinal Permeability and Bowel Function in Diarrhea-predominant Irritable Bowel Syndrome (D-IBS) Completed NCT00911612 Phase 2 Colesevelam;Placebo
4 Multicentre Randomized Controlled Trial for Quantity-Effect Relationship of Acupuncture With Two-ways Regulation to Treat Functional Enteropathy Unknown status NCT01274793 Phase 1 Mosapride Citrate tablet
5 Assessment of Elemental Impurities Level After Chronic Administration of Diosmectite (SMECTA®) in Subjects With Chronic Diarrhoea Completed NCT03045926 Phase 1 Diosmectite (Smecta®)
6 Clinical Efficacy of Probiotic Bacteria in Subjects With Irritable Bowel Syndrome (IBS), Functional Diarrhea, or Functional Bloating Completed NCT00618904
7 Gluten Intolerance in Irritable Bowel Syndrome With Diarrhea: The Role of HLA-DQ2 Completed NCT01094041
8 Clinical Efficacy of Yogurt Containing Bifidobacterium Lactis (BB12) in Subjects With Functional Gastrointestinal Symptoms Completed NCT00618488

Search NIH Clinical Center for Functional Diarrhea

Genetic Tests for Functional Diarrhea

Anatomical Context for Functional Diarrhea

MalaCards organs/tissues related to Functional Diarrhea:

40
Colon, Testes, Small Intestine, Brain, Thyroid, Hypothalamus, Skin

Publications for Functional Diarrhea

Articles related to Functional Diarrhea:

(show top 50) (show all 151)
# Title Authors PMID Year
1
Similarities in Clinical and Psychosocial Characteristics of Functional Diarrhea and Irritable Bowel Syndrome With Diarrhea. 61
31442602 2020
2
Epidemiological, Clinical, and Psychological Characteristics of Individuals with Self-reported Irritable Bowel Syndrome Based on the Rome IV vs Rome III Criteria. 61
31154027 2020
3
Canadian Association of Gastroenterology Clinical Practice Guideline on the Management of Bile Acid Diarrhea. 61
32010878 2020
4
Canadian Association of Gastroenterology Clinical Practice Guideline on the Management of Bile Acid Diarrhea. 61
31526844 2020
5
Prevalence of Rome IV Functional Bowel Disorders Among Adults in the United States, Canada, and the United Kingdom. 61
31917991 2020
6
Susceptibility to diarrhea is related to hemodynamic markers of sympathetic activation in the general population. 61
31791149 2019
7
What's in the pipeline for lower functional gastrointestinal disorders in the next 5 years? 61
31460793 2019
8
Data Mining Approach for the Characterization of Functional Bowel Disorders According to Symptom Intensity Provides a Small Number of Homogenous Groups. 61
31775138 2019
9
Neonatal Antibiotics and Prematurity Are Associated with an Increased Risk of Functional Gastrointestinal Disorders in the First Year of Life. 61
31201028 2019
10
Highlights of the AGA Technical Review on Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome. 61
31787857 2019
11
AGA Clinical Practice Guidelines on the Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D): Patient Summary. 61
31378676 2019
12
AGA Clinical Practice Guidelines on the Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D). 61
31302098 2019
13
Spotlight: Laboratory Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D). 61
31377275 2019
14
Use of Bioelectronics in the Gastrointestinal Tract. 61
30249600 2019
15
AGA Technical Review on the Evaluation of Functional Diarrhea and Diarrhea-Predominant Irritable Bowel Syndrome in Adults (IBS-D). 61
31351880 2019
16
[Electroacupuncture improves intestinal function by down-regulating expression of 5-HT1AR and c-fos proteins in the hypothalamus and colon tissues via brain-gut axis in rats with functional diarrhea]. 61
31368281 2019
17
Chronic Diarrhea Evaluation in the Elderly: IBS or Something Else? 61
31346793 2019
18
[Zaburzenia czynnoĹ›ciowe przewodu pokarmowego u osób z przerostem bakteryjnym jelita cienkiego]. 61
31260431 2019
19
Analysis of Fecal Primary Bile Acids Detects Increased Stool Weight and Colonic Transit in Patients With Chronic Functional Diarrhea. 61
29902647 2019
20
Adverse drug reactions of Yunnan Baiyao capsule: a multi-center intensive monitoring study in China. 61
31032273 2019
21
Risk factors for upper and lower functional gastrointestinal disorders in Persian Gulf War Veterans during and post-deployment. 61
30697884 2019
22
Rebamipide increases the disaccharidases activity in patients with enteropathy with impaired membrane digestion. Pilot study. 61
31094168 2019
23
The Relation between Dietary Patterns and Functional Gastrointestinal Disorders among Iranian Military Men. 61
30775344 2019
24
Beneficial effects of Saccharomyces boulardii CNCM I-745 on clinical disorders associated with intestinal barrier disruption. 61
30804678 2019
25
Development of a Brief Parent-Report Screen for Common Gastrointestinal Disorders in Autism Spectrum Disorder. 61
30350113 2019
26
Clinical and psychological correlates of soiling in adult patients with functional gastrointestinal disorders. 61
29987361 2018
27
Multicenter observational study on functional bowel disorders diagnosed using Rome III diagnostic criteria in Japan. 61
29305648 2018
28
The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study. 61
29684865 2018
29
Association Between Ultra-Processed Food Consumption and Functional Gastrointestinal Disorders: Results From the French NutriNet-Santé Cohort. 61
29904158 2018
30
[Nutritional management of functional chronic diarrhea associated to malnutrition with peptide diet: a case report]. 61
29974788 2018
31
Functional Gastrointestinal Disorders: Functional Gastrointestinal Disorders in Children. 61
29528207 2018
32
[Influence of cow's milk protein allergy on the diagnosis of functional gastrointestinal diseases based on the Rome IV standard in infants and young children]. 61
29335084 2018
33
The role of fermentable carbohydrates and beverages in the symptomatology of functional gastrointestinal disease. 61
28826271 2017
34
Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity. 61
28573751 2017
35
Saccharomyces boulardii CNCM I-745 Restores intestinal Barrier Integrity by Regulation of E-cadherin Recycling. 61
28333335 2017
36
Rome foundation Asian working team report: Real world treatment experience of Asian patients with functional bowel disorders. 61
28084664 2017
37
What Is New in Rome IV. 61
28274109 2017
38
Diagnostic Yield and Clinical Impact of Video Capsule Endoscopy in Patients with Chronic Diarrhea: A Korean Multicenter CAPENTRY Study. 61
27840367 2017
39
The New Rome IV Criteria for Functional Gastrointestinal Disorders in Infants and Toddlers. 61
28401050 2017
40
Clinical, psychological, and physiological correlates of patients who defecate after meal. 61
27824643 2017
41
[Disaccharidase deficiency and functional bowel diseases]. 61
28514399 2017
42
Acupuncture for chronic diarrhea in adults: Protocol for a systematic review. 61
28121941 2017
43
Therapeutic Modulation of Gut Microbiota in Functional Bowel Disorders. 61
28049862 2017
44
Effects of electronically stimulating Tianshu (ST 25) and Dachangshu (BL 25), Quchi (LI 11) and Shangjuxu (ST 37) on the expressions of jejunum c-kit protein and c-kit mRNA in rats with functional diarrhea. 61
29949711 2016
45
Physical inactivity during leisure time and irregular meals are associated with functional gastrointestinal complaints in middle-aged and elder subjects. 61
27435884 2016
46
Smoking is associated with several functional gastrointestinal symptoms. 61
27160318 2016
47
Pharmacological interventions on early functional gastrointestinal disorders. 61
27423188 2016
48
Electroacupuncture for patients with diarrhea-predominant irritable bowel syndrome or functional diarrhea: A randomized controlled trial. 61
27310980 2016
49
Development and Validation of a Rome III Functional Gastrointestinal Disorders Questionnaire for Infants and Toddlers. 61
26308319 2016
50
Bowel Disorders. 61
27144627 2016

Variations for Functional Diarrhea

Expression for Functional Diarrhea

Search GEO for disease gene expression data for Functional Diarrhea.

Pathways for Functional Diarrhea

GO Terms for Functional Diarrhea

Cellular components related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 membrane GO:0016020 9.9 SLC10A2 PDZD3 NPR3 KLB HTR3A GPBAR1
2 integral component of membrane GO:0016021 9.65 SLC10A2 NPR3 KLB HTR3A GPBAR1 FGFR4
3 integral component of plasma membrane GO:0005887 9.1 SLC10A2 NPR3 HTR3A FGFR4 CLCN2 ATP4A

Biological processes related to Functional Diarrhea according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein kinase B signaling GO:0051897 9.67 KLB FGFR4 FGF19
2 ion transmembrane transport GO:0034220 9.62 HTR3A CLCN2 ATP4A ATP12A
3 cholesterol homeostasis GO:0042632 9.54 NR1H4 FGFR4 CYP7A1
4 bile acid and bile salt transport GO:0015721 9.51 SLC10A2 NR1H4
5 cellular sodium ion homeostasis GO:0006883 9.48 ATP4A ATP12A
6 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.46 ATP4A ATP12A
7 sodium ion export across plasma membrane GO:0036376 9.43 ATP4A ATP12A
8 fibroblast growth factor receptor signaling pathway GO:0008543 9.43 KLB FGFR4 FGF19
9 ion transport GO:0006811 9.43 SLC10A2 PDZD3 HTR3A CLCN2 ATP4A ATP12A
10 cellular potassium ion homeostasis GO:0030007 9.4 ATP4A ATP12A
11 negative regulation of bile acid biosynthetic process GO:0070858 9.16 NR1H4 FGF19
12 regulation of bile acid biosynthetic process GO:0070857 8.8 NR1H4 FGFR4 CYP7A1

Molecular functions related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 fibroblast growth factor receptor binding GO:0005104 9.37 KLB FGF19
2 fibroblast growth factor binding GO:0017134 9.32 KLB FGFR4
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.26 ATP4A ATP12A
4 potassium-transporting ATPase activity GO:0008556 9.16 ATP4A ATP12A
5 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP4A ATP12A
6 bile acid receptor activity GO:0038181 8.62 NR1H4 GPBAR1

Sources for Functional Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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