MCID: FNC002
MIFTS: 35

Functional Diarrhea

Categories: Gastrointestinal diseases

Aliases & Classifications for Functional Diarrhea

MalaCards integrated aliases for Functional Diarrhea:

Name: Functional Diarrhea 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:11371
ICD9CM 36 564.5
SNOMED-CT 69 47812002
ICD10 34 K59.1
UMLS 74 C0156173

Summaries for Functional Diarrhea

MalaCards based summary : Functional Diarrhea is related to constipation and fungal esophagitis, and has symptoms including constipation, diarrhea and vomiting following gastrointestinal surgery. An important gene associated with Functional Diarrhea is FGF19 (Fibroblast Growth Factor 19), and among its related pathways/superpathways is Farnesoid X Receptor Pathway. The drugs Loperamide and Baclofen have been mentioned in the context of this disorder. Affiliated tissues include colon, and related phenotypes are growth/size/body region and digestive/alimentary

Related Diseases for Functional Diarrhea

Diseases related to Functional Diarrhea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 65)
# Related Disease Score Top Affiliating Genes
1 constipation 29.5 FGF19 HTR3A NTS TAC1
2 fungal esophagitis 10.3 ATP12A ATP4A
3 diclofenac allergy 10.3 ATP12A ATP4A
4 gastroduodenal crohn's disease 10.3 ATP12A ATP4A
5 neonatal candidiasis 10.3 ATP12A ATP4A
6 photoallergic dermatitis 10.3 ATP12A ATP4A
7 squamous papillomatosis 10.3 ATP12A ATP4A
8 toxic megacolon 10.3 ATP12A ATP4A
9 aspiration pneumonitis 10.3 ATP12A ATP4A
10 gastrointestinal neuroendocrine benign tumor 10.3 ATP12A ATP4A
11 gastric antral vascular ectasia 10.3 ATP12A ATP4A
12 granulomatous gastritis 10.3 ATP12A ATP4A
13 esophageal candidiasis 10.3 ATP12A ATP4A
14 gastric neuroendocrine neoplasm 10.3 ATP12A ATP4A
15 acute laryngitis 10.3 ATP12A ATP4A
16 laryngitis 10.3 ATP12A ATP4A
17 duodenitis 10.3 ATP12A ATP4A
18 active peptic ulcer disease 10.3 ATP12A ATP4A
19 congenital disorder of deglycosylation 10.3 ATP12A ATP4A
20 bladder calculus 10.3 ATP12A ATP4A
21 ischemic neuropathy 10.3 ATP12A ATP4A
22 bile reflux 10.3 ATP12A ATP4A
23 capillary disease 10.3 ATP12A ATP4A
24 peptic esophagitis 10.3 ATP12A ATP4A
25 dyskinesia of esophagus 10.3 ATP12A ATP4A
26 hernia, hiatus 10.3 ATP12A ATP4A
27 postsurgical hypothyroidism 10.3 ATP12A ATP4A
28 lymphocytic colitis 10.3 ATP12A ATP4A
29 esophageal atresia/tracheoesophageal fistula 10.3 ATP12A ATP4A
30 clostridium difficile colitis 10.3 ATP12A ATP4A
31 diarrhea 10.3
32 diarrhea 1, secretory chloride, congenital 10.3 ATP12A ATP4A
33 esophagitis, eosinophilic, 1 10.3 ATP12A ATP4A
34 microscopic colitis 10.3 ATP12A ATP4A
35 laryngeal tuberculosis 10.3 ATP12A ATP4A
36 chronic laryngitis 10.3 ATP12A ATP4A
37 eosinophilic gastritis 10.2 ATP12A ATP4A
38 esophagus adenocarcinoma 10.2 ATP12A ATP4A
39 chronic intestinal vascular insufficiency 10.2 ATP12A ATP4A
40 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ATP12A ATP4A
41 jejunoileitis 10.2 ATP12A ATP4A
42 rumination disorder 10.2 ATP12A ATP4A HTR3A
43 superior mesenteric artery syndrome 10.2 ATP12A ATP4A HTR3A
44 esophageal varix 10.2 ATP12A ATP4A
45 gastric lymphoma 10.2 ATP12A ATP4A
46 lower urinary tract calculus 10.2 ATP12A ATP4A
47 myopathy, x-linked, with excessive autophagy 10.1 ATP12A ATP4A
48 microinvasive gastric cancer 10.1 ATP12A ATP4A CDH1
49 laryngeal disease 10.1 ATP12A ATP4A CDH1
50 motion sickness 10.1 HTR3A TAC1

Comorbidity relations with Functional Diarrhea via Phenotypic Disease Network (PDN):


Acute Cystitis Heart Disease

Graphical network of the top 20 diseases related to Functional Diarrhea:



Diseases related to Functional Diarrhea

Symptoms & Phenotypes for Functional Diarrhea

UMLS symptoms related to Functional Diarrhea:


constipation, diarrhea, vomiting following gastrointestinal surgery

MGI Mouse Phenotypes related to Functional Diarrhea:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.9 ATP12A CDH1 CDK5RAP2 EDN1 FGF19 GPBAR1
2 digestive/alimentary MP:0005381 9.87 ATP12A ATP4A CDH1 EDN1 GHRL NR1H4
3 endocrine/exocrine gland MP:0005379 9.86 ATP4A CDH1 EDN1 GHRL GPBAR1 HTR3A
4 homeostasis/metabolism MP:0005376 9.77 ATP12A ATP4A CDH1 DNTT EDN1 FGF19
5 immune system MP:0005387 9.28 ATP4A CDH1 CDK5RAP2 DNTT GPBAR1 HTR3A

Drugs & Therapeutics for Functional Diarrhea

Drugs for Functional Diarrhea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Loperamide Approved Phase 2, Phase 3 53179-11-6 3955
2
Baclofen Approved Phase 3 1134-47-0 2284
3
Omeprazole Approved, Investigational, Vet_approved Phase 3 73590-58-6 4594
4
Desipramine Approved, Investigational Phase 3 50-47-5 2995
5 Gastrointestinal Agents Phase 2, Phase 3,Phase 1
6 Neurotransmitter Agents Phase 3,Phase 1
7 Antidiarrheals Phase 2, Phase 3
8 Proton Pump Inhibitors Phase 3
9 Antidepressive Agents, Tricyclic Phase 3
10 Adrenergic Agents Phase 3
11 Antidepressive Agents Phase 3
12 Neurotransmitter Uptake Inhibitors Phase 3
13 Psychotropic Drugs Phase 3
14
Sodium Citrate Approved, Investigational Phase 1 68-04-2
15
Citric Acid Approved, Nutraceutical, Vet_approved Phase 1 77-92-9 311
16
Calcium Approved, Nutraceutical Phase 1 7440-70-2 271
17 Mosapride Investigational Phase 1 112885-41-3
18 Chelating Agents Phase 1
19 Serotonin Agents Phase 1
20 Serotonin Receptor Agonists Phase 1
21 Citrate Phase 1
22 Calcium, Dietary Phase 1
23 Anticoagulants Phase 1
24
Serotonin Investigational, Nutraceutical Phase 1 50-67-9 5202
25 Acidophilus Not Applicable
26 Bifidobacterium Not Applicable
27 Cola Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Acupuncture for Patients With Diarrhea-predominant IBS or Functional Diarrhea: a Randomized Controlled Trial Completed NCT01350570 Phase 2, Phase 3 Loperamide
2 A Randomized Trial of Medical and Surgical Treatments for Patients With GERD Symptoms That Are Refractory to Proton Pump Inhibitors Completed NCT01265550 Phase 3 baclofen;Desipramine
3 Trial for Quantity-Effect Relationship of Acupuncture With Two-ways Regulation to Treat Functional Enteropathy Unknown status NCT01274793 Phase 1 Mosapride Citrate tablet
4 Chronic Administration of Diosmectite (SMECTA®) in Subjects With Chronic Diarrhoea Completed NCT03045926 Phase 1 Diosmectite (Smecta®)
5 Efficacy of Probiotic Bacteria in Subjects With IBS or Functional Diarrhea/ Bloating Completed NCT00618904 Not Applicable
6 Health Education Delivery Methods for a Low Fermentable Carbohydrate Diet in Patients With Functional Bowel Disorders Completed NCT03694223 Not Applicable
7 Gluten Intolerance in Patients With Diarrhea Predominant Irritable Bowel Syndrome Completed NCT01094041 Not Applicable

Search NIH Clinical Center for Functional Diarrhea

Genetic Tests for Functional Diarrhea

Anatomical Context for Functional Diarrhea

MalaCards organs/tissues related to Functional Diarrhea:

42
Colon

Publications for Functional Diarrhea

Articles related to Functional Diarrhea:

(show all 18)
# Title Authors Year
1
Analysis of Fecal Primary Bile Acids Detects Increased Stool Weight and Colonic Transit in Patients with Chronic Functional Diarrhea. ( 29902647 )
2018
2
The effect of fecal microbiota transplantation on psychiatric symptoms among patients with irritable bowel syndrome, functional diarrhea and functional constipation: An open-label observational study. ( 29684865 )
2018
3
Early weaning stress induces chronic functional diarrhea, intestinal barrier defects, and increased mast cell activity in a porcine model of early life adversity. ( 28573751 )
2017
4
Electroacupuncture for patients with diarrhea-predominant irritable bowel syndrome or functional diarrhea: A randomized controlled trial. ( 27310980 )
2016
5
Effects of electronically stimulating Tianshu (ST 25) and Dachangshu (BL 25), Quchi (LI 11) and Shangjuxu (ST 37) on the expressions of jejunum c-kit protein and c-kit mRNA in rats with functional diarrhea. ( 29949711 )
2016
6
Influence of acupuncture stimulation on cerebral network in functional diarrhea. ( 24459533 )
2013
7
Functional diarrhea. ( 22917168 )
2012
8
Epidemiology of functional diarrhea and comparison with diarrhea-predominant irritable bowel syndrome: a population-based survey in China. ( 22937091 )
2012
9
Development of functional diarrhea, constipation, irritable bowel syndrome, and dyspepsia during and after traveling outside the USA. ( 17549631 )
2008
10
Treatment of functional diarrhea. ( 16836952 )
2006
11
Functional diarrhea. ( 16168232 )
2005
12
Effects of probiotic administration upon the composition and enzymatic activity of human fecal microbiota in patients with irritable bowel syndrome or functional diarrhea. ( 11686387 )
2001
13
Inhibition of gastric secretion relieves diarrhea and postprandial urgency associated with irritable bowel syndrome or functional diarrhea. ( 10505731 )
1999
14
Rapid gastric emptying in patients with functional diarrhea. ( 9121178 )
1997
15
Colonic motility and functional diarrhea. ( 1622483 )
1992
16
Effect of eating on colonic motility and transit in patients with functional diarrhea. Simultaneous scintigraphic and manometric evaluations. ( 1936800 )
1991
17
Functional diarrhea: an analysis of the clinical and roentgen manifestations. ( 13397691 )
1956
18
Alterations in colonic function in man under stress; hypomotility of the sigmoid colon, and its relationship to the mechanism of functional diarrhea. ( 15421433 )
1950

Variations for Functional Diarrhea

Expression for Functional Diarrhea

Search GEO for disease gene expression data for Functional Diarrhea.

Pathways for Functional Diarrhea

Pathways related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.9 FGF19 NR1H4

GO Terms for Functional Diarrhea

Cellular components related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axon GO:0030424 9.46 GHRL HTR3A RAB11A TAC1
2 glutamatergic synapse GO:0098978 9.26 CDH1 GHRL HTR3A RAB11A
3 transport vesicle GO:0030133 8.92 EDN1 NTS RAB11A TOR1A

Biological processes related to Functional Diarrhea according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.84 EDN1 FGF19 GHRL NTS
2 positive regulation of cytosolic calcium ion concentration GO:0007204 9.69 EDN1 GHRL TAC1
3 neuron projection development GO:0031175 9.67 CDH1 RAB11A TOR1A
4 ATP hydrolysis coupled proton transport GO:0015991 9.55 ATP12A ATP4A
5 cellular response to fatty acid GO:0071398 9.52 EDN1 NR1H4
6 regulation of pH GO:0006885 9.48 ATP12A EDN1
7 regulation of blood vessel size GO:0050880 9.46 EDN1 NTS
8 cellular sodium ion homeostasis GO:0006883 9.43 ATP12A ATP4A
9 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.4 ATP12A ATP4A
10 positive regulation of renal sodium excretion GO:0035815 9.37 EDN1 TAC1
11 cellular potassium ion homeostasis GO:0030007 9.32 ATP12A ATP4A
12 sodium ion export across plasma membrane GO:0036376 9.26 ATP12A ATP4A
13 negative regulation of tumor necrosis factor secretion GO:1904468 9.16 GHRL NR1H4
14 negative regulation of bile acid biosynthetic process GO:0070858 8.96 FGF19 NR1H4
15 positive regulation of adipose tissue development GO:1904179 8.62 GHRL NR1H4

Molecular functions related to Functional Diarrhea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
2 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A
3 bile acid receptor activity GO:0038181 8.62 GPBAR1 NR1H4

Sources for Functional Diarrhea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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