MCID: FNC006
MIFTS: 25

Functional Gastric Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Functional Gastric Disease

MalaCards integrated aliases for Functional Gastric Disease:

Name: Functional Gastric Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1159
ICD9CM 35 536.8
UMLS 73 C0013396

Summaries for Functional Gastric Disease

MalaCards based summary : Functional Gastric Disease is related to fungal esophagitis and bladder calculus. An important gene associated with Functional Gastric Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and Ion channel transport. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Functional Gastric Disease

Diseases related to Functional Gastric Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 93)
# Related Disease Score Top Affiliating Genes
1 fungal esophagitis 10.9 ATP12A ATP4A
2 bladder calculus 10.9 ATP12A ATP4A
3 neonatal candidiasis 10.9 ATP12A ATP4A
4 squamous papillomatosis 10.9 ATP12A ATP4A
5 acute laryngitis 10.9 ATP12A ATP4A
6 gastroduodenal crohn's disease 10.9 ATP12A ATP4A
7 toxic megacolon 10.8 ATP12A ATP4A
8 postsurgical hypothyroidism 10.8 ATP12A ATP4A
9 esophageal candidiasis 10.8 ATP12A ATP4A
10 duodenitis 10.8 ATP12A ATP4A
11 granulomatous gastritis 10.8 ATP12A ATP4A
12 laryngeal disease 10.8 ATP12A ATP4A
13 ischemic neuropathy 10.8 ATP12A ATP4A
14 capillary disease 10.8 ATP12A ATP4A
15 dyskinesia of esophagus 10.8 ATP12A ATP4A
16 hernia, hiatus 10.8 ATP12A ATP4A
17 congenital disorder of deglycosylation 10.8 ATP12A ATP4A
18 anismus 10.8 ATP12A ATP4A
19 esophageal atresia/tracheoesophageal fistula 10.8 ATP12A ATP4A
20 laryngeal tuberculosis 10.8 ATP12A ATP4A
21 lymphocytic colitis 10.8 ATP12A ATP4A
22 clostridium difficile colitis 10.8 ATP12A ATP4A
23 lower urinary tract calculus 10.7 ATP12A ATP4A
24 diarrhea 1, secretory chloride, congenital 10.7 ATP12A ATP4A
25 eosinophilic gastritis 10.7 ATP12A ATP4A
26 polyposis, skin pigmentation, alopecia, and fingernail changes 10.7 ATP12A ATP4A
27 esophagus adenocarcinoma 10.7 ATP12A ATP4A
28 aspiration pneumonia 10.6 ATP12A ATP4A TRPV1
29 paine syndrome 10.6 ATP12A ATP4A TRPV1
30 myopathy, x-linked, with excessive autophagy 10.6 ATP12A ATP4A
31 gastric lymphoma 10.6 ATP12A ATP4A
32 duodenal disease 10.6 ATP12A ATP4A CCK
33 pneumatosis cystoides intestinalis 10.6 ATP12A ATP4A
34 gastrointestinal neuroendocrine benign tumor 10.6 ATP12A ATP4A SST
35 growth hormone secreting pituitary adenoma 10.6 GHSR SST
36 gastric neuroendocrine neoplasm 10.6 ATP12A ATP4A SST
37 gastric antral vascular ectasia 10.5 ATP12A ATP4A SST
38 social phobia 10.5 CCK HTR3A
39 jejunoileitis 10.5 ATP12A ATP4A
40 esophageal varix 10.5 ATP12A ATP4A SST
41 chronic intestinal vascular insufficiency 10.5 ATP12A ATP4A SPAG7
42 glucose metabolism disease 10.5 GHRL SST TRPV1
43 duodenal gastrinoma 10.5 CCK SST
44 acquired metabolic disease 10.5 GHRL SST TRPV1
45 pancreas disease 10.5 CCK SST TRPV1
46 superior mesenteric artery syndrome 10.5 ATP12A ATP4A HTR3A
47 aspiration pneumonitis 10.4 ATP12A ATP4A HRH2
48 peptic esophagitis 10.4 ATP12A ATP4A HRH2
49 laryngitis 10.4 ATP12A ATP4A HRH2
50 chronic laryngitis 10.4 ATP12A ATP4A HRH2

Graphical network of the top 20 diseases related to Functional Gastric Disease:



Diseases related to Functional Gastric Disease

Symptoms & Phenotypes for Functional Gastric Disease

GenomeRNAi Phenotypes related to Functional Gastric Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.44 GHSR HRH2 HTR3A MLN
2 Decreased viability GR00381-A-2 9.44 GHSR
3 Decreased viability GR00381-A-3 9.44 GHSR HRH2 HTR3A MLN
4 Decreased viability GR00402-S-2 9.44 GHSR HRH2 HTR3A MLN

MGI Mouse Phenotypes related to Functional Gastric Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 CCK GHRL GHSR HRH2 HTR3A HTR7
2 digestive/alimentary MP:0005381 9.5 PTGS2 SST ATP12A ATP4A GHRL GHSR
3 homeostasis/metabolism MP:0005376 9.36 ATP12A ATP4A CCK GHRL GHSR HRH2

Drugs & Therapeutics for Functional Gastric Disease

Search Clinical Trials , NIH Clinical Center for Functional Gastric Disease

Genetic Tests for Functional Gastric Disease

Anatomical Context for Functional Gastric Disease

Publications for Functional Gastric Disease

Variations for Functional Gastric Disease

Expression for Functional Gastric Disease

Search GEO for disease gene expression data for Functional Gastric Disease.

Pathways for Functional Gastric Disease

GO Terms for Functional Gastric Disease

Cellular components related to Functional Gastric Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron projection GO:0043005 9.26 GHSR HTR3A PTGS2 TRPV1
2 neuronal cell body GO:0043025 8.92 CCK HTR3A SST TRPV1

Biological processes related to Functional Gastric Disease according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.95 CCK GHRL MLN SST
2 ion transmembrane transport GO:0034220 9.88 ATP12A ATP4A HTR3A TRPV1
3 excitatory postsynaptic potential GO:0060079 9.71 GHRL HTR3A TRPV1
4 ATP hydrolysis coupled proton transport GO:0015991 9.65 ATP12A ATP4A
5 negative regulation of insulin secretion GO:0046676 9.64 GHRL GHSR
6 positive regulation of sprouting angiogenesis GO:1903672 9.63 GHRL GHSR
7 positive regulation of vascular endothelial cell proliferation GO:1905564 9.63 GHRL GHSR
8 cellular sodium ion homeostasis GO:0006883 9.62 ATP12A ATP4A
9 cellular potassium ion homeostasis GO:0030007 9.62 ATP12A ATP4A
10 sodium ion export across plasma membrane GO:0036376 9.61 ATP12A ATP4A
11 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.61 ATP12A ATP4A
12 cellular response to ATP GO:0071318 9.6 PTGS2 TRPV1
13 actin polymerization or depolymerization GO:0008154 9.59 GHRL GHSR
14 positive regulation of growth GO:0045927 9.58 GHRL GHSR
15 adult feeding behavior GO:0008343 9.57 GHRL GHSR
16 negative regulation of appetite GO:0032099 9.56 CCK GHSR
17 negative regulation of interleukin-1 beta production GO:0032691 9.55 GHRL GHSR
18 negative regulation of tumor necrosis factor secretion GO:1904468 9.52 GHRL GHSR
19 growth hormone secretion GO:0030252 9.51 GHRL GHSR
20 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.49 GHRL GHSR
21 negative regulation of interleukin-6 biosynthetic process GO:0045409 9.48 GHRL GHSR
22 positive regulation of appetite GO:0032100 9.46 GHRL GHSR
23 positive regulation of eating behavior GO:1904000 9.43 GHRL GHSR
24 response to organonitrogen compound GO:0010243 9.43 PTGS2 SST TRPV1
25 regulation of transmission of nerve impulse GO:0051969 9.4 GHRL GHSR
26 regulation of gastric motility GO:1905333 9.37 GHRL GHSR
27 positive regulation of small intestine smooth muscle contraction GO:1904349 9.32 GHRL GHSR
28 G-protein coupled receptor signaling pathway GO:0007186 9.23 CCK GHRL GHSR HRH2 HTR7 MLN
29 positive regulation of small intestinal transit GO:0120058 9.16 GHRL GHSR
30 decidualization GO:0046697 9.13 GHRL GHSR PTGS2
31 signal transduction GO:0007165 10.18 CCK GHSR HRH2 HTR3A HTR7 MLNR

Molecular functions related to Functional Gastric Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 sodium:potassium-exchanging ATPase activity GO:0005391 9.32 ATP12A ATP4A
2 serotonin binding GO:0051378 9.26 HTR3A HTR7
3 growth hormone-releasing hormone receptor activity GO:0016520 9.16 GHSR MLNR
4 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A
5 hormone activity GO:0005179 8.92 CCK GHRL MLN SST

Sources for Functional Gastric Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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