MCID: FNC006
MIFTS: 25

Functional Gastric Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Functional Gastric Disease

MalaCards integrated aliases for Functional Gastric Disease:

Name: Functional Gastric Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1159
ICD9CM 34 536.8
UMLS 71 C0013396

Summaries for Functional Gastric Disease

MalaCards based summary : Functional Gastric Disease is related to pylorospasm and vagus nerve disease. An important gene associated with Functional Gastric Disease is MLNR (Motilin Receptor), and among its related pathways/superpathways are Signaling by GPCR and Peptide ligand-binding receptors. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Functional Gastric Disease

Diseases related to Functional Gastric Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 209)
# Related Disease Score Top Affiliating Genes
1 pylorospasm 10.6 MLNR MLN
2 vagus nerve disease 10.5 ATP4A ATP12A
3 hemangioma of intra-abdominal structure 10.5 ATP4A ATP12A
4 acquired gastric outlet stenosis 10.5 ATP4A ATP12A
5 angiodysplasia of intestine 10.5 ATP4A ATP12A
6 benzylpenicillin allergy 10.5 ATP4A ATP12A
7 bacterial esophagitis 10.5 ATP4A ATP12A
8 lingual goiter 10.5 ATP4A ATP12A
9 cascade stomach 10.5 ATP4A ATP12A
10 gastrojejunal ulcer 10.5 ATP4A ATP12A
11 median arcuate ligament syndrome 10.5 ATP4A ATP12A
12 laryngeal tuberculosis 10.5 ATP4A ATP12A
13 fungal esophagitis 10.5 ATP4A ATP12A
14 dieulafoy lesion 10.5 ATP4A ATP12A
15 esophagus melanoma 10.5 ATP4A ATP12A
16 necrotizing gastritis 10.5 ATP4A ATP12A
17 cervix erosion 10.5 ATP4A ATP12A
18 chronic laryngitis 10.5 ATP4A ATP12A
19 cefuroxime allergy 10.5 ATP4A ATP12A
20 polyposis, skin pigmentation, alopecia, and fingernail changes 10.5 ATP4A ATP12A
21 adenosquamous bile duct carcinoma 10.5 GIP GCG
22 acute laryngitis 10.5 ATP4A ATP12A
23 petrositis 10.5 SST GCG
24 internal hemorrhoid 10.5 ATP4A ATP12A
25 gastric dilatation 10.5 ATP4A ATP12A
26 scalp dermatosis 10.5 ATP4A ATP12A
27 central nervous system origin vertigo 10.4 ATP4A ATP12A
28 superior mesenteric artery syndrome 10.4 MLNR ATP4A ATP12A
29 diclofenac allergy 10.4 ATP4A ATP12A
30 functional colonic disease 10.4 SST MLNR MLN
31 blind loop syndrome 10.4 MLN ATP4A ATP12A
32 colonic pseudo-obstruction 10.4 SST MLNR MLN
33 pituitary infarct 10.4 SST INS
34 cardiomyopathy, dilated, 1gg 10.4 MLN ATP4A ATP12A
35 dyskinesia of esophagus 10.4 MLN ATP4A ATP12A
36 lymphocytic gastritis 10.4 ATP4A ATP12A
37 x-linked chondrodysplasia punctata 1 10.4 ATP4A ATP12A
38 acute insulin response 10.4 INS GCG
39 auditory system cancer 10.4 PPY GCG
40 mediastinitis 10.4 INS ATP4A ATP12A
41 acidophil adenoma 10.4 SST INS
42 abnormality of glucagon secretion 10.4 SST GHRL GCG
43 drug allergy 10.4 INS ATP4A ATP12A
44 abdominal obesity-metabolic syndrome 1 10.4 INS GHRL GCG
45 eosinophilic gastritis 10.4 ATP4A ATP12A
46 glossitis 10.4 GCG ATP4A ATP12A
47 emphysematous cholecystitis 10.4 CCK ATP4A ATP12A
48 gastrointestinal neuroendocrine benign tumor 10.4 SST GAST
49 duodenal obstruction 10.4 ATP4A ATP12A
50 idiopathic gastroparesis 10.4 GIP GHSR GHRL

Graphical network of the top 20 diseases related to Functional Gastric Disease:



Diseases related to Functional Gastric Disease

Symptoms & Phenotypes for Functional Gastric Disease

GenomeRNAi Phenotypes related to Functional Gastric Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00240-S-1 9.91 SST
2 Decreased viability GR00249-S 9.91 ATP12A ATP4A GCG GHRL GHSR MLN
3 Decreased viability GR00381-A-1 9.91 GHSR HTR3A MLN MLNR PYY
4 Decreased viability GR00381-A-2 9.91 GHSR
5 Decreased viability GR00381-A-3 9.91 GHSR HTR3A MLN
6 Decreased viability GR00386-A-1 9.91 CCK GCG MLN SI
7 Decreased viability GR00402-S-2 9.91 GHSR HTR3A MLN PYY SPAG7 SYMPK

MGI Mouse Phenotypes related to Functional Gastric Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.9 ATP12A GHRL GHSR HTR3A INS NTS
2 digestive/alimentary MP:0005381 9.56 ATP12A ATP4A GAST GHRL GHSR GIP
3 homeostasis/metabolism MP:0005376 9.47 ATP12A ATP4A CCK GAST GHRL GHSR

Drugs & Therapeutics for Functional Gastric Disease

Search Clinical Trials , NIH Clinical Center for Functional Gastric Disease

Genetic Tests for Functional Gastric Disease

Anatomical Context for Functional Gastric Disease

Publications for Functional Gastric Disease

Articles related to Functional Gastric Disease:

# Title Authors PMID Year
1
Effects of a Herbal Medicine, Yukgunja-Tang, on Functional Dyspepsia Patients Classified by 3-Dimensional Facial Measurement: A Study Protocol for Placebo-Controlled, Double-Blind, Randomized Trial. 61
28400841 2017
2
Probiotic Lactobacillus reuteri alleviates the response to gastric distension in rats. 61
21880952 2011

Variations for Functional Gastric Disease

Expression for Functional Gastric Disease

Search GEO for disease gene expression data for Functional Gastric Disease.

Pathways for Functional Gastric Disease

GO Terms for Functional Gastric Disease

Cellular components related to Functional Gastric Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.65 SST PYY PPY INS GIP GHRL
2 endoplasmic reticulum lumen GO:0005788 9.56 INS GIP GHRL GCG
3 secretory granule lumen GO:0034774 9.46 INS GIP GHRL GCG
4 extracellular region GO:0005576 9.4 VIP SST PYY PPY NTS MLN

Biological processes related to Functional Gastric Disease according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 neuropeptide signaling pathway GO:0007218 9.77 PYY PPY NTS
2 signal transduction GO:0007165 9.7 VIP PPY NTS MLNR INS HTR3A
3 negative regulation of interleukin-6 biosynthetic process GO:0045409 9.62 GHSR GHRL
4 negative regulation of interleukin-1 beta production GO:0032691 9.61 GHSR GHRL
5 cellular sodium ion homeostasis GO:0006883 9.61 ATP4A ATP12A
6 negative regulation of tumor necrosis factor secretion GO:1904468 9.6 GHSR GHRL
7 sodium ion export across plasma membrane GO:0036376 9.58 ATP4A ATP12A
8 cellular potassium ion homeostasis GO:0030007 9.58 ATP4A ATP12A
9 response to acidic pH GO:0010447 9.57 SST GIP
10 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.56 ATP4A ATP12A
11 positive regulation of growth GO:0045927 9.55 GHSR GHRL
12 adult feeding behavior GO:0008343 9.54 GHSR GHRL
13 feeding behavior GO:0007631 9.54 PYY PPY GCG
14 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.52 GHSR GHRL
15 negative regulation of appetite GO:0032099 9.51 GHSR CCK
16 postsynaptic modulation of chemical synaptic transmission GO:0099170 9.49 GHSR GHRL
17 growth hormone secretion GO:0030252 9.48 GHSR GHRL
18 G protein-coupled receptor signaling pathway GO:0007186 9.47 VIP SST PYY PPY NTS MLNR
19 positive regulation of eating behavior GO:1904000 9.46 GHSR GHRL
20 regulation of transmission of nerve impulse GO:0051969 9.43 GHSR GHRL
21 positive regulation of appetite GO:0032100 9.4 GHSR GHRL
22 regulation of gastric motility GO:1905333 9.32 GHSR GHRL
23 positive regulation of small intestine smooth muscle contraction GO:1904349 9.26 GHSR GHRL
24 positive regulation of small intestinal transit GO:0120058 9.16 GHSR GHRL

Molecular functions related to Functional Gastric Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor binding GO:0001664 9.54 PYY PPY GHRL
2 hormone binding GO:0042562 9.46 MLNR GHSR
3 sodium:potassium-exchanging ATPase activity GO:0005391 9.43 ATP4A ATP12A
4 peptide hormone receptor binding GO:0051428 9.4 VIP CCK
5 hormone activity GO:0005179 9.36 VIP SST PYY PPY MLN INS
6 neuropeptide hormone activity GO:0005184 9.35 VIP PYY PPY NTS CCK
7 potassium-transporting ATPase activity GO:0008556 9.32 ATP4A ATP12A
8 potassium:proton exchanging ATPase activity GO:0008900 9.26 ATP4A ATP12A
9 glucagon receptor binding GO:0031769 9.16 GIP GCG

Sources for Functional Gastric Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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