MCID: FNC006
MIFTS: 28

Functional Gastric Disease

Categories: Gastrointestinal diseases

Aliases & Classifications for Functional Gastric Disease

MalaCards integrated aliases for Functional Gastric Disease:

Name: Functional Gastric Disease 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:1159
ICD9CM 35 536.8
UMLS 73 C0013396

Summaries for Functional Gastric Disease

MalaCards based summary : Functional Gastric Disease is related to fungal esophagitis and diclofenac allergy. An important gene associated with Functional Gastric Disease is TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1), and among its related pathways/superpathways are Peptide ligand-binding receptors and Ion channel transport. Affiliated tissues include skin, colon and pituitary, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Functional Gastric Disease

Diseases related to Functional Gastric Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 109)
# Related Disease Score Top Affiliating Genes
1 fungal esophagitis 10.3 ATP12A ATP4A
2 diclofenac allergy 10.3 ATP12A ATP4A
3 gastroduodenal crohn's disease 10.3 ATP12A ATP4A
4 neonatal candidiasis 10.3 ATP12A ATP4A
5 photoallergic dermatitis 10.3 ATP12A ATP4A
6 squamous papillomatosis 10.3 ATP12A ATP4A
7 toxic megacolon 10.3 ATP12A ATP4A
8 granulomatous gastritis 10.3 ATP12A ATP4A
9 esophageal candidiasis 10.3 ATP12A ATP4A
10 acute laryngitis 10.3 ATP12A ATP4A
11 congenital disorder of deglycosylation 10.3 ATP12A ATP4A
12 bladder calculus 10.3 ATP12A ATP4A
13 ischemic neuropathy 10.3 ATP12A ATP4A
14 capillary disease 10.3 ATP12A ATP4A
15 dyskinesia of esophagus 10.3 ATP12A ATP4A
16 hernia, hiatus 10.3 ATP12A ATP4A
17 anismus 10.3 ATP12A ATP4A
18 postsurgical hypothyroidism 10.3 ATP12A ATP4A
19 lymphocytic colitis 10.3 ATP12A ATP4A
20 esophageal atresia/tracheoesophageal fistula 10.2 ATP12A ATP4A
21 clostridium difficile colitis 10.2 ATP12A ATP4A
22 diarrhea 1, secretory chloride, congenital 10.2 ATP12A ATP4A
23 microscopic colitis 10.2 ATP12A ATP4A
24 laryngeal tuberculosis 10.2 ATP12A ATP4A
25 eosinophilic gastritis 10.2 ATP12A ATP4A
26 esophagus adenocarcinoma 10.2 ATP12A ATP4A
27 polyposis, skin pigmentation, alopecia, and fingernail changes 10.2 ATP12A ATP4A
28 aspiration pneumonia 10.2 ATP12A ATP4A TRPV1
29 jejunoileitis 10.2 ATP12A ATP4A
30 paine syndrome 10.2 ATP12A ATP4A TRPV1
31 growth hormone secreting pituitary adenoma 10.2 GHSR SST
32 gastric lymphoma 10.2 ATP12A ATP4A
33 lower urinary tract calculus 10.2 ATP12A ATP4A
34 bile reflux 10.2 ATP12A ATP4A CCK
35 gastrointestinal neuroendocrine benign tumor 10.2 ATP12A ATP4A SST
36 gastric antral vascular ectasia 10.2 ATP12A ATP4A SST
37 gastric neuroendocrine neoplasm 10.2 ATP12A ATP4A SST
38 myopathy, x-linked, with excessive autophagy 10.2 ATP12A ATP4A
39 social phobia 10.2 CCK HTR3A
40 esophageal varix 10.2 ATP12A ATP4A SST
41 pneumatosis cystoides intestinalis 10.2 ATP12A ATP4A SST
42 chronic intestinal vascular insufficiency 10.2 ATP12A ATP4A SPAG7
43 superior mesenteric artery syndrome 10.1 ATP12A ATP4A HTR3A
44 duodenal gastrinoma 10.1 CCK SST
45 lateral medullary syndrome 10.1 ATP12A ATP4A
46 aspiration pneumonitis 10.1 ATP12A ATP4A HRH2
47 active peptic ulcer disease 10.1 ATP12A ATP4A HRH2
48 peptic esophagitis 10.1 ATP12A ATP4A HRH2
49 laryngitis 10.1 ATP12A ATP4A HRH2
50 chronic laryngitis 10.1 ATP12A ATP4A HRH2

Graphical network of the top 20 diseases related to Functional Gastric Disease:



Diseases related to Functional Gastric Disease

Symptoms & Phenotypes for Functional Gastric Disease

GenomeRNAi Phenotypes related to Functional Gastric Disease according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00381-A-1 9.44 GHSR HRH2 HTR3A MLN
2 Decreased viability GR00381-A-2 9.44 GHSR
3 Decreased viability GR00381-A-3 9.44 GHSR HRH2 HTR3A MLN
4 Decreased viability GR00402-S-2 9.44 GHSR HRH2 HTR3A MLN

MGI Mouse Phenotypes related to Functional Gastric Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.81 CCK GHRL GHSR HRH2 HTR3A HTR7
2 digestive/alimentary MP:0005381 9.5 ATP12A ATP4A GHRL GHSR HRH2 INS
3 homeostasis/metabolism MP:0005376 9.36 ATP12A ATP4A CCK GHRL GHSR HRH2

Drugs & Therapeutics for Functional Gastric Disease

Search Clinical Trials , NIH Clinical Center for Functional Gastric Disease

Genetic Tests for Functional Gastric Disease

Anatomical Context for Functional Gastric Disease

MalaCards organs/tissues related to Functional Gastric Disease:

41
Skin, Colon, Pituitary, Pancreas

Publications for Functional Gastric Disease

Variations for Functional Gastric Disease

Expression for Functional Gastric Disease

Search GEO for disease gene expression data for Functional Gastric Disease.

Pathways for Functional Gastric Disease

GO Terms for Functional Gastric Disease

Cellular components related to Functional Gastric Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 dendrite GO:0030425 9.26 CCK HRH2 HTR7 TRPV1
2 neuronal cell body GO:0043025 8.92 CCK HTR3A SST TRPV1

Biological processes related to Functional Gastric Disease according to GeneCards Suite gene sharing:

(show all 31)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.85 CCK GHRL INS MLN SST
2 chemical synaptic transmission GO:0007268 9.84 HRH2 HTR3A HTR7 SST
3 excitatory postsynaptic potential GO:0060079 9.69 GHRL HTR3A TRPV1
4 ATP hydrolysis coupled proton transport GO:0015991 9.65 ATP12A ATP4A
5 negative regulation of insulin secretion GO:0046676 9.65 GHRL GHSR
6 positive regulation of sprouting angiogenesis GO:1903672 9.64 GHRL GHSR
7 decidualization GO:0046697 9.64 GHRL GHSR
8 positive regulation of vascular endothelial cell proliferation GO:1905564 9.63 GHRL GHSR
9 regulation of postsynapse organization GO:0099175 9.63 GHRL GHSR
10 cellular sodium ion homeostasis GO:0006883 9.62 ATP12A ATP4A
11 establishment or maintenance of transmembrane electrochemical gradient GO:0010248 9.61 ATP12A ATP4A
12 actin polymerization or depolymerization GO:0008154 9.61 GHRL GHSR
13 cellular potassium ion homeostasis GO:0030007 9.6 ATP12A ATP4A
14 sodium ion export across plasma membrane GO:0036376 9.59 ATP12A ATP4A
15 positive regulation of growth GO:0045927 9.58 GHRL GHSR
16 adult feeding behavior GO:0008343 9.58 GHRL GHSR
17 negative regulation of interleukin-1 beta production GO:0032691 9.57 GHRL GHSR
18 negative regulation of appetite GO:0032099 9.56 CCK GHSR
19 postsynaptic modulation of chemical synaptic transmission GO:0099170 9.55 GHRL GHSR
20 negative regulation of tumor necrosis factor secretion GO:1904468 9.52 GHRL GHSR
21 growth hormone secretion GO:0030252 9.49 GHRL GHSR
22 negative regulation of tumor necrosis factor biosynthetic process GO:0042536 9.48 GHRL GHSR
23 negative regulation of interleukin-6 biosynthetic process GO:0045409 9.43 GHRL GHSR
24 positive regulation of appetite GO:0032100 9.4 GHRL GHSR
25 positive regulation of eating behavior GO:1904000 9.37 GHRL GHSR
26 regulation of transmission of nerve impulse GO:0051969 9.32 GHRL GHSR
27 G protein-coupled receptor signaling pathway GO:0007186 9.28 CCK GHRL GHSR HRH2 HTR7 INS
28 positive regulation of small intestine smooth muscle contraction GO:1904349 9.26 GHRL GHSR
29 regulation of gastric motility GO:1905333 9.16 GHRL GHSR
30 positive regulation of small intestinal transit GO:0120058 8.96 GHRL GHSR
31 signal transduction GO:0007165 10.16 CCK GHSR HRH2 HTR3A HTR7 MLNR

Molecular functions related to Functional Gastric Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone binding GO:0042562 9.26 GHSR MLNR
2 sodium:potassium-exchanging ATPase activity GO:0005391 9.16 ATP12A ATP4A
3 hormone activity GO:0005179 9.02 CCK GHRL INS MLN SST
4 potassium:proton exchanging ATPase activity GO:0008900 8.96 ATP12A ATP4A

Sources for Functional Gastric Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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