MCID: FNC007
MIFTS: 36

Functioning Pituitary Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Functioning Pituitary Adenoma

MalaCards integrated aliases for Functioning Pituitary Adenoma:

Name: Functioning Pituitary Adenoma 12 15
Secretory Adenoma of the Pituitary Gland 12
Pituitary Adenoma, Functioning 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5395
NCIt 50 C8388
UMLS 73 C0854486

Summaries for Functioning Pituitary Adenoma

MalaCards based summary : Functioning Pituitary Adenoma, also known as secretory adenoma of the pituitary gland, is related to non-functioning pituitary adenoma and acth-secreting pituitary adenoma. An important gene associated with Functioning Pituitary Adenoma is SST (Somatostatin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Development_Leptin signaling via JAK/STAT and MAPK cascades. Affiliated tissues include pituitary, prostate and testes, and related phenotypes are growth/size/body region and endocrine/exocrine gland

Related Diseases for Functioning Pituitary Adenoma

Diseases related to Functioning Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 non-functioning pituitary adenoma 32.5 GH1 GHR MUC1 PTPN3 S100B SST
2 acth-secreting pituitary adenoma 32.2 POMC PRL
3 pituitary adenoma 1, multiple types 30.7 AIP GH1 PRL SST
4 lymphocytic hypophysitis 30.5 GH1 POMC
5 hypoadrenalism 30.4 GH1 POMC
6 hypopituitarism 30.1 GH1 POMC PRL
7 craniopharyngioma 29.9 GH1 PRL TRH
8 pituitary carcinoma 29.9 POMC PRL SST
9 pituitary apoplexy 29.2 AIP POMC PRL
10 adenoma 28.3 AIP GH1 MEN1 POMC PRL SST
11 hyperprolactinemia 27.5 DRD2 GH1 POMC PRL SST TRH
12 pituitary tumors 26.8 AIP GH1 MEN1 POMC PRL SST
13 acromegaly 25.6 AIP GH1 GHR MEN1 POMC PRL
14 functionless pituitary adenoma 11.4
15 pituitary adenoma 4, acth-secreting 11.0
16 pituitary adenoma 2, growth hormone-secreting 11.0
17 pituitary adenoma 5, multiple types 11.0
18 pituitary adenoma 3, multiple types 11.0
19 villous adenoma 10.7 MUC1 SST
20 ampulla of vater neoplasm 10.7 MUC1 SST
21 fibrous dysplasia/mccune-albright syndrome 10.7 GH1 PRL
22 localized hypertrophic neuropathy 10.7 MUC1 S100B
23 sclerosing perineurioma 10.7 MUC1 S100B
24 intracranial cysts 10.7 MUC1 S100B
25 reticular perineurioma 10.7 MUC1 S100B
26 pituitary adenoma 10.7
27 bronchus adenoma 10.7 POMC SST
28 epithelioid malignant peripheral nerve sheath tumor 10.7 MUC1 S100B
29 ossifying fibromyxoid tumor 10.7 MUC1 S100B
30 fibrous meningioma 10.7 MUC1 S100B
31 chordoid meningioma 10.7 MUC1 S100B
32 acidophil adenoma 10.7 POMC SST
33 syringocystadenoma papilliferum 10.7 MUC1 S100B
34 eccrine porocarcinoma 10.7 MUC1 S100B
35 spindle cell rhabdomyosarcoma 10.7 MUC1 S100B
36 aggressive digital papillary adenocarcinoma 10.7 MUC1 S100B
37 myxopapillary ependymoma 10.7 MUC1 S100B
38 monophasic synovial sarcoma 10.7 MUC1 S100B
39 chordoid glioma 10.6 MUC1 S100B
40 spiradenoma 10.6 MUC1 S100B
41 syringoma 10.6 MUC1 S100B
42 pleomorphic liposarcoma 10.6 MUC1 S100B
43 anaplastic ependymoma 10.6 MUC1 S100B
44 perineurioma 10.6 MUC1 S100B
45 spindle cell sarcoma 10.6 MUC1 S100B
46 papilloma of choroid plexus 10.6 MUC1 S100B
47 meningeal melanocytoma 10.6 MUC1 S100B
48 head injury 10.5 PRL S100B
49 dendritic cell tumor 10.5 MUC1 S100B
50 mixed ductal-endocrine carcinoma 10.5 MUC1 SST

Graphical network of the top 20 diseases related to Functioning Pituitary Adenoma:



Diseases related to Functioning Pituitary Adenoma

Symptoms & Phenotypes for Functioning Pituitary Adenoma

MGI Mouse Phenotypes related to Functioning Pituitary Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 9.92 PTPN3 AIP SST DRD2 TRH GHR
2 endocrine/exocrine gland MP:0005379 9.91 DRD2 TRH GHR MEN1 POMC PRL
3 homeostasis/metabolism MP:0005376 9.91 S100B SST DRD2 TRH GHR MEN1
4 integument MP:0010771 9.63 PRL AIP S100B DRD2 GHR POMC
5 liver/biliary system MP:0005370 9.43 DRD2 GHR MEN1 POMC PRL AIP
6 neoplasm MP:0002006 9.02 PRL AIP DRD2 MEN1 POMC

Drugs & Therapeutics for Functioning Pituitary Adenoma

Search Clinical Trials , NIH Clinical Center for Functioning Pituitary Adenoma

Genetic Tests for Functioning Pituitary Adenoma

Anatomical Context for Functioning Pituitary Adenoma

MalaCards organs/tissues related to Functioning Pituitary Adenoma:

41
Pituitary, Prostate, Testes, Endothelial, Thyroid, Brain, Lung

Publications for Functioning Pituitary Adenoma

Articles related to Functioning Pituitary Adenoma:

(show top 50) (show all 105)
# Title Authors Year
1
Stereotactic radiation therapy for the treatment of functional pituitary adenomas associated with feline acromegaly. ( 29782043 )
2018
2
EVALUATION OF CARDIOVASCULAR RISK WITH ARTERIAL STIFFNESS IN PATIENTS WITH NON-FUNCTIONING PITUITARY ADENOMA. ( 29975581 )
2018
3
Data of phosphoproteomic analysis of non-functioning pituitary adenoma. ( 29900237 )
2018
4
Mortality in patients with non-functioning pituitary adenoma. ( 29344906 )
2018
5
Malignant transformation in non-functioning pituitary adenomas (pituitary carcinoma). ( 29299820 )
2018
6
Incidence of malignant tumours in patients with a non-functioning pituitary adenoma. ( 28274953 )
2017
7
Non-functioning pituitary adenoma underwent surgery: A multicenter retrospective study over the last four decades (1977-2015). ( 28389053 )
2017
8
Increased I^a89catenin and c-myc expression predict aggressive growth of non-functioning pituitary adenomas: An assessment using a tissue microarray-based approach. ( 28260015 )
2017
9
Integrative proteomics and transcriptomics identify novel invasive-related biomarkers of non-functioning pituitary adenomas. ( 26753958 )
2016
10
Time trends of mortality in patients with non-functioning pituitary adenoma: a Swedish nationwide study. ( 27743172 )
2016
11
Relationship of each anterior pituitary hormone deficiency to the size of non-functioning pituitary adenoma in the hospitalized patients. ( 27534814 )
2016
12
Higher Incidence of Morbidity in Women than Men with Non-functioning Pituitary Adenoma: a Swedish Nationwide Study. ( 27147638 )
2016
13
SNPs in the aryl hydrocarbon receptor-interacting protein gene associated with sporadic non-functioning pituitary adenoma. ( 26998050 )
2016
14
Clinical Concerns about Recurrence of Non-Functioning Pituitary Adenoma. ( 27195254 )
2016
15
Management of clinically non-functioning pituitary adenoma. ( 26072284 )
2015
16
Biological and radiological exploration and management of non-functioning pituitary adenoma. ( 26122495 )
2015
17
Hypothalamic-Pituitary Axis in Non-Functioning Pituitary Adenomas: Focus on the Prevalence of Isolated Central Hypoadrenalism. ( 25924873 )
2015
18
Post-surgical management of non-functioning pituitary adenoma. ( 26116412 )
2015
19
Neuro-ophthalmologic exploration in non-functioning pituitary adenoma. ( 26070465 )
2015
20
Brain abnormalities on MRI in non-functioning pituitary adenoma patients treated with or without postoperative radiotherapy. ( 25596913 )
2015
21
Non-functioning pituitary adenoma: when and how to operate? What pathologic criteria for typing? ( 26070464 )
2015
22
Dopamine 2 and somatostatin 1-5 receptors coexpression in clinically non-functioning pituitary adenomas. ( 25536318 )
2015
23
MORTALITY IN PATIENTS WITH NON-FUNCTIONING PITUITARY ADENOMA IS INCREASED: SYSTEMATIC ANALYSIS OF 546 CASES WITH LONG FOLLOW-UP. ( 26546611 )
2015
24
Candida albicans endophthalmitis in a patient with a non-functioning pituitary adenoma evolving into Cushingx^s disease: A case report. ( 25379398 )
2014
25
Medical management of functioning pituitary adenoma: an update. ( 26236804 )
2014
26
Analysis of short- and long-term metabolic effects of growth hormone replacement therapy in adult patients with craniopharyngioma and non-functioning pituitary adenoma. ( 25330765 )
2014
27
Cluster headache associated with a clinically non-functioning pituitary adenoma: a case report. ( 25526868 )
2014
28
Medical management of functioning pituitary adenoma: an update. ( 25446388 )
2014
29
Spontaneous regression of non-functioning pituitary adenoma due to pituitary apoplexy following anticoagulation treatment - a case report and review of the literature. ( 23450448 )
2013
30
ZAC1 and SSTR2 are downregulated in non-functioning pituitary adenomas but not in somatotropinomas. ( 24098585 )
2013
31
Self-perception of cognitive function among patients with active acromegaly, controlled acromegaly, and non-functional pituitary adenoma: a pilot study. ( 24282035 )
2013
32
Peptide receptor radionuclide therapy in a patient with disabling non-functioning pituitary adenoma. ( 23740146 )
2013
33
Results of Immunohistochemical staining of cell cycle regulators - the prediction of recurrence of functioning pituitary adenoma. ( 24067736 )
2013
34
Functional Pituitary Adenoma Recurrence after Surgical Resection. ( 24215871 )
2013
35
Intraoperative MRI and endocrinological outcome of transsphenoidal surgery for non-functioning pituitary adenoma. ( 22286656 )
2012
36
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. ( 22824692 )
2012
37
Treatment with octreotide LAR in clinically non-functioning pituitary adenoma: results from a case-control study. ( 22207350 )
2012
38
Dopamine 2 receptor expression in various pathological types of clinically non-functioning pituitary adenomas. ( 21597974 )
2012
39
Expression of genes FOLR1, BAG1 and LAPTM4B in functioning and non-functioning pituitary adenomas. ( 23023342 )
2012
40
Expression of CRABP1, GRP, and RERG mRNA in clinically non-functioning and functioning pituitary adenomas. ( 21270509 )
2011
41
Pituitary apoplexy in non-functioning pituitary adenomas: long term follow up is important because of significant numbers of tumour recurrences. ( 21521336 )
2011
42
Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma? ( 21900406 )
2011
43
Co-expression of somatostatin receptor subtypes and estrogen receptor-I+ mRNAs by non-functioning pituitary adenomas in young patients. ( 20797424 )
2011
44
Non-functioning pituitary adenoma and concomitant Rathke's cleft cyst. ( 21934255 )
2011
45
Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer. ( 19842040 )
2010
46
Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. ( 20022992 )
2010
47
Prevalence of gsp oncogene in somatotropinomas and clinically non-functioning pituitary adenomas: our experience. ( 18642089 )
2009
48
Non-functioning pituitary adenomas: clinical feature, laboratorial and imaging assessment, therapeutic management and outcome. ( 19347183 )
2009
49
GH replacement in patients with non-functioning pituitary adenoma (NFA) treated solely by surgery is not associated with increased risk of tumour recurrence. ( 19236640 )
2009
50
Comparing progression of non-functioning pituitary adenomas in hypopituitarism patients with and without long-term GH replacement therapy. ( 19734242 )
2009

Variations for Functioning Pituitary Adenoma

Expression for Functioning Pituitary Adenoma

Search GEO for disease gene expression data for Functioning Pituitary Adenoma.

Pathways for Functioning Pituitary Adenoma

GO Terms for Functioning Pituitary Adenoma

Cellular components related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 GH1 GHR MUC1 POMC PRL S100B
2 extracellular region GO:0005576 9.56 GH1 GHR MUC1 POMC PRL S100B
3 endosome lumen GO:0031904 9.26 GH1 PRL
4 growth hormone receptor complex GO:0070195 8.62 GH1 GHR

Biological processes related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell-cell signaling GO:0007267 9.67 DRD2 POMC SST TRH
2 regulation of signaling receptor activity GO:0010469 9.65 GH1 POMC PRL SST TRH
3 response to morphine GO:0043278 9.48 DRD2 GHR
4 adult walking behavior GO:0007628 9.46 DRD2 TRH
5 regulation of multicellular organism growth GO:0040014 9.43 GHR PRL
6 positive regulation of receptor internalization GO:0002092 9.4 DRD2 GH1
7 positive regulation of multicellular organism growth GO:0040018 9.33 DRD2 GH1 GHR
8 growth hormone receptor signaling pathway GO:0060396 9.32 GH1 GHR
9 positive regulation of JAK-STAT cascade GO:0046427 9.13 GH1 GHR PRL
10 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.8 GH1 GHR PRL

Molecular functions related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.02 GH1 POMC PRL SST TRH
2 prolactin receptor binding GO:0005148 8.96 GH1 PRL

Sources for Functioning Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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