MCID: FNC007
MIFTS: 39

Functioning Pituitary Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Functioning Pituitary Adenoma

MalaCards integrated aliases for Functioning Pituitary Adenoma:

Name: Functioning Pituitary Adenoma 12 15
Secretory Adenoma of the Pituitary Gland 12
Pituitary Adenoma, Functioning 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5395
NCIt 50 C8388
UMLS 73 C0854486

Summaries for Functioning Pituitary Adenoma

MalaCards based summary : Functioning Pituitary Adenoma, also known as secretory adenoma of the pituitary gland, is related to non-functioning pituitary adenoma and pituitary adenoma 1, multiple types. An important gene associated with Functioning Pituitary Adenoma is SST (Somatostatin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Growth hormone receptor signaling. Affiliated tissues include pituitary, brain and prostate, and related phenotypes are endocrine/exocrine gland and growth/size/body region

Related Diseases for Functioning Pituitary Adenoma

Diseases related to Functioning Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 152)
# Related Disease Score Top Affiliating Genes
1 non-functioning pituitary adenoma 33.4 GH1 GHR MUC1 PTPN3 S100B SST
2 pituitary adenoma 1, multiple types 31.9 GH1 PRL SST
3 acth-secreting pituitary adenoma 31.9 POMC PRL
4 pituitary apoplexy 30.3 POMC PRL
5 adenoma 30.3 GH1 MEN1 POMC PRL SST SSTR5
6 hypopituitarism 30.1 GH1 POMC PRL
7 lymphocytic hypophysitis 30.0 GH1 POMC
8 hypoadrenalism 30.0 GH1 POMC
9 pituitary carcinoma 29.8 POMC PRL SST
10 craniopharyngioma 29.8 GH1 PRL TRH
11 conn's syndrome 29.3 GH1 MEN1 POMC PRL SST
12 thyroid carcinoma, familial medullary 29.2 MEN1 POMC SST SSTR5
13 hyperprolactinemia 29.1 DRD2 GH1 POMC PRL SST TRH
14 pituitary tumors 28.9 GH1 MEN1 POMC PRL SST SSTR5
15 acromegaly 28.8 GH1 GHR MEN1 POMC PRL SST
16 functionless pituitary adenoma 11.5
17 pituitary adenoma 4, acth-secreting 11.2
18 pituitary adenoma 2, growth hormone-secreting 11.2
19 pituitary adenoma 5, multiple types 11.2
20 pituitary adenoma 3, multiple types 11.2
21 pituitary adenoma 10.7
22 isolated growth hormone deficiency, type ib 10.2 GH1 GHR
23 fibrous dysplasia/mccune-albright syndrome 10.2 GH1 PRL
24 pancreatoblastoma 10.2 MUC1 SST
25 localized hypertrophic neuropathy 10.2 MUC1 S100B
26 sclerosing perineurioma 10.2 MUC1 S100B
27 bronchus adenoma 10.2 POMC SST
28 perineurioma 10.2 MUC1 S100B
29 bronchial adenomas/carcinoids childhood 10.2 POMC SST
30 intracranial cysts 10.2 MUC1 S100B
31 reticular perineurioma 10.2 MUC1 S100B
32 acidophil adenoma 10.2 POMC SST
33 syringocystadenoma papilliferum 10.2 MUC1 S100B
34 villous adenoma 10.2 MUC1 SST
35 epithelioid malignant peripheral nerve sheath tumor 10.2 MUC1 S100B
36 gigantism 10.2 GH1 PRL
37 ossifying fibromyxoid tumor 10.2 MUC1 S100B
38 fibrous meningioma 10.2 MUC1 S100B
39 chordoid meningioma 10.2 MUC1 S100B
40 eccrine porocarcinoma 10.2 MUC1 S100B
41 spindle cell rhabdomyosarcoma 10.2 MUC1 S100B
42 growth hormone secreting pituitary adenoma 10.2 PRL SST
43 aggressive digital papillary adenocarcinoma 10.2 MUC1 S100B
44 myxopapillary ependymoma 10.2 MUC1 S100B
45 monophasic synovial sarcoma 10.2 MUC1 S100B
46 chordoid glioma 10.2 MUC1 S100B
47 syringoma 10.2 MUC1 S100B
48 pleomorphic liposarcoma 10.2 MUC1 S100B
49 spinocerebellar degeneration 10.2 PRL SST
50 anaplastic ependymoma 10.2 MUC1 S100B

Graphical network of the top 20 diseases related to Functioning Pituitary Adenoma:



Diseases related to Functioning Pituitary Adenoma

Symptoms & Phenotypes for Functioning Pituitary Adenoma

MGI Mouse Phenotypes related to Functioning Pituitary Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.7 DRD2 GHR MEN1 POMC PRL SSTR5
2 growth/size/body region MP:0005378 9.56 DRD2 GHR MEN1 POMC PTPN3 SST
3 homeostasis/metabolism MP:0005376 9.28 DRD2 GHR MEN1 POMC PRL S100B

Drugs & Therapeutics for Functioning Pituitary Adenoma

Search Clinical Trials , NIH Clinical Center for Functioning Pituitary Adenoma

Genetic Tests for Functioning Pituitary Adenoma

Anatomical Context for Functioning Pituitary Adenoma

MalaCards organs/tissues related to Functioning Pituitary Adenoma:

41
Pituitary, Brain, Prostate, Thyroid, Small Intestine, Cortex, Adrenal Gland

Publications for Functioning Pituitary Adenoma

Articles related to Functioning Pituitary Adenoma:

(show top 50) (show all 66)
# Title Authors Year
1
EVALUATION OF CARDIOVASCULAR RISK WITH ARTERIAL STIFFNESS IN PATIENTS WITH NON-FUNCTIONING PITUITARY ADENOMA. ( 29975581 )
2018
2
Data of phosphoproteomic analysis of non-functioning pituitary adenoma. ( 29900237 )
2018
3
Mortality in patients with non-functioning pituitary adenoma. ( 29344906 )
2018
4
Genome-wide identification of lncRNAs and mRNAs differentially expressed in non-functioning pituitary adenoma and construction of a lncRNA-mRNA co-expression network. ( 30504132 )
2018
5
A two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma. ( 30542712 )
2018
6
Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement ( 30299891 )
2018
7
Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement. ( 30049813 )
2018
8
Incidence of malignant tumours in patients with a non-functioning pituitary adenoma. ( 28274953 )
2017
9
Non-functioning pituitary adenoma underwent surgery: A multicenter retrospective study over the last four decades (1977-2015). ( 28389053 )
2017
10
Time trends of mortality in patients with non-functioning pituitary adenoma: a Swedish nationwide study. ( 27743172 )
2016
11
Relationship of each anterior pituitary hormone deficiency to the size of non-functioning pituitary adenoma in the hospitalized patients. ( 27534814 )
2016
12
Higher Incidence of Morbidity in Women than Men with Non-functioning Pituitary Adenoma: a Swedish Nationwide Study. ( 27147638 )
2016
13
SNPs in the aryl hydrocarbon receptor-interacting protein gene associated with sporadic non-functioning pituitary adenoma. ( 26998050 )
2016
14
Clinical Concerns about Recurrence of Non-Functioning Pituitary Adenoma. ( 27195254 )
2016
15
Management of clinically non-functioning pituitary adenoma. ( 26072284 )
2015
16
Biological and radiological exploration and management of non-functioning pituitary adenoma. ( 26122495 )
2015
17
Post-surgical management of non-functioning pituitary adenoma. ( 26116412 )
2015
18
Neuro-ophthalmologic exploration in non-functioning pituitary adenoma. ( 26070465 )
2015
19
Brain abnormalities on MRI in non-functioning pituitary adenoma patients treated with or without postoperative radiotherapy. ( 25596913 )
2015
20
Non-functioning pituitary adenoma: when and how to operate? What pathologic criteria for typing? ( 26070464 )
2015
21
MORTALITY IN PATIENTS WITH NON-FUNCTIONING PITUITARY ADENOMA IS INCREASED: SYSTEMATIC ANALYSIS OF 546 CASES WITH LONG FOLLOW-UP. ( 26546611 )
2015
22
Candida albicans endophthalmitis in a patient with a non-functioning pituitary adenoma evolving into Cushingx^s disease: A case report. ( 25379398 )
2014
23
Medical management of functioning pituitary adenoma: an update. ( 26236804 )
2014
24
Analysis of short- and long-term metabolic effects of growth hormone replacement therapy in adult patients with craniopharyngioma and non-functioning pituitary adenoma. ( 25330765 )
2014
25
Cluster headache associated with a clinically non-functioning pituitary adenoma: a case report. ( 25526868 )
2014
26
Medical management of functioning pituitary adenoma: an update. ( 25446388 )
2014
27
Spontaneous regression of non-functioning pituitary adenoma due to pituitary apoplexy following anticoagulation treatment - a case report and review of the literature. ( 23450448 )
2013
28
Peptide receptor radionuclide therapy in a patient with disabling non-functioning pituitary adenoma. ( 23740146 )
2013
29
Results of Immunohistochemical staining of cell cycle regulators - the prediction of recurrence of functioning pituitary adenoma. ( 24067736 )
2013
30
Intraoperative MRI and endocrinological outcome of transsphenoidal surgery for non-functioning pituitary adenoma. ( 22286656 )
2012
31
Combined gangliocytoma and non-functioning pituitary adenoma of the pituitary gland. ( 22824692 )
2012
32
Treatment with octreotide LAR in clinically non-functioning pituitary adenoma: results from a case-control study. ( 22207350 )
2012
33
Can we ever stop imaging in surgically treated and radiotherapy-naive patients with non-functioning pituitary adenoma? ( 21900406 )
2011
34
Non-functioning pituitary adenoma and concomitant Rathke's cleft cyst. ( 21934255 )
2011
35
Apoplexy in non functioning pituitary adenoma after one dose of leuprolide as treatment for prostate cancer. ( 19842040 )
2010
36
Metabolic, cardiovascular, and cerebrovascular outcomes in growth hormone-deficient subjects with previous cushing's disease or non-functioning pituitary adenoma. ( 20022992 )
2010
37
GH replacement in patients with non-functioning pituitary adenoma (NFA) treated solely by surgery is not associated with increased risk of tumour recurrence. ( 19236640 )
2009
38
Lymphocytic hypophysitis occurring simultaneously with a functioning pituitary adenoma. ( 18497455 )
2008
39
Non-functioning pituitary adenoma: immunohistochemical analysis of 85 cases. ( 17594597 )
2007
40
Hypophysitis superimposed on a non-functioning pituitary adenoma: diagnostic clinical, endocrine, and radiologic features. ( 17923800 )
2007
41
Clinically non-functioning pituitary adenoma. ( 17082898 )
2006
42
Pituitary metastasis masquerading as non-functioning pituitary adenoma in a woman with adenocarcinoma lung. ( 16832588 )
2006
43
Frequent occurrence of pituitary apoplexy in patients with non-functioning pituitary adenoma. ( 16487443 )
2006
44
Non-functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumors. ( 17132751 )
2006
45
A non-functioning pituitary adenoma initially mimicking a microprolactinoma: The case for long-term follow-up of patients with mild hyperprolactinemia? ( 15966512 )
2005
46
[A case of a hemorrhagic non-functioning pituitary adenoma presenting with abducens nerve palsy]. ( 15912767 )
2005
47
SIADH closely associated with non-functioning pituitary adenoma. ( 15351800 )
2004
48
The diaphragma sellae meningioma -- a rare differential diagnosis of non-functioning pituitary adenoma. ( 15551185 )
2004
49
Idiopathic granulomatous hypophysitis presenting as non-functioning pituitary adenoma: description of six cases and review of literature. ( 15799151 )
2004
50
A case of non-functioning pituitary adenoma with Cushing's syndrome upon recurrence. ( 11837535 )
2001

Variations for Functioning Pituitary Adenoma

Expression for Functioning Pituitary Adenoma

Search GEO for disease gene expression data for Functioning Pituitary Adenoma.

Pathways for Functioning Pituitary Adenoma

GO Terms for Functioning Pituitary Adenoma

Cellular components related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 GH1 GHR MUC1 POMC PRL S100B
2 extracellular region GO:0005576 9.56 GH1 GHR MUC1 POMC PRL S100B
3 secretory granule GO:0030141 9.43 POMC PRL TRH
4 endosome lumen GO:0031904 9.32 GH1 PRL
5 growth hormone receptor complex GO:0070195 8.62 GH1 GHR

Biological processes related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 G protein-coupled receptor signaling pathway GO:0007186 9.91 DRD2 POMC SST SSTR5 TRH
2 cell-cell signaling GO:0007267 9.71 POMC SST TRH
3 negative regulation of cell proliferation GO:0008285 9.71 DRD2 MEN1 SST SSTR5
4 regulation of signaling receptor activity GO:0010469 9.65 GH1 POMC PRL SST TRH
5 response to ethanol GO:0045471 9.54 DRD2 PRL TRH
6 positive regulation of cytokinesis GO:0032467 9.52 DRD2 SSTR5
7 adult walking behavior GO:0007628 9.49 DRD2 TRH
8 response to morphine GO:0043278 9.48 DRD2 GHR
9 regulation of multicellular organism growth GO:0040014 9.46 GHR PRL
10 positive regulation of receptor internalization GO:0002092 9.43 DRD2 GH1
11 positive regulation of multicellular organism growth GO:0040018 9.33 DRD2 GH1 GHR
12 growth hormone receptor signaling pathway GO:0060396 9.32 GH1 GHR
13 positive regulation of JAK-STAT cascade GO:0046427 9.13 GH1 GHR PRL
14 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 8.8 GH1 GHR PRL

Molecular functions related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.02 GH1 POMC PRL SST TRH
2 prolactin receptor binding GO:0005148 8.96 GH1 PRL

Sources for Functioning Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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