MCID: FNC007
MIFTS: 43

Functioning Pituitary Adenoma

Categories: Cancer diseases, Endocrine diseases, Rare diseases

Aliases & Classifications for Functioning Pituitary Adenoma

MalaCards integrated aliases for Functioning Pituitary Adenoma:

Name: Functioning Pituitary Adenoma 12 58 15
Secretory Adenoma of the Pituitary Gland 12
Endocrine Active Pituitary Adenoma 58
Pituitary Adenoma, Functioning 71
Secreting Pituitary Adenoma 58

Classifications:

Orphanet: 58  
Rare endocrine diseases


External Ids:

Disease Ontology 12 DOID:5395
NCIt 49 C8388
UMLS via Orphanet 72 C0854486
Orphanet 58 ORPHA314753
UMLS 71 C0854486

Summaries for Functioning Pituitary Adenoma

MalaCards based summary : Functioning Pituitary Adenoma, also known as secretory adenoma of the pituitary gland, is related to non-functioning pituitary adenoma and growth hormone secreting pituitary adenoma. An important gene associated with Functioning Pituitary Adenoma is SST (Somatostatin), and among its related pathways/superpathways are Peptide ligand-binding receptors and Aldosterone synthesis and secretion. The drugs Octreotide and Metformin have been mentioned in the context of this disorder. Affiliated tissues include pituitary, bone and brain, and related phenotypes are homeostasis/metabolism and endocrine/exocrine gland

Related Diseases for Functioning Pituitary Adenoma

Diseases related to Functioning Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 347)
# Related Disease Score Top Affiliating Genes
1 non-functioning pituitary adenoma 34.6 SST S100B GHR GH1 CDK6
2 growth hormone secreting pituitary adenoma 33.9 SSTR5 SSTR2 SST PRL POMC MEN1
3 tsh producing pituitary tumor 33.3 SSTR5 SSTR2 SST PRL GH1
4 functionless pituitary adenoma 32.8 SSTR5 SSTR2 SST POMC IGF1
5 pituitary adenoma 1, multiple types 32.2 SST PRL MEN1 IGF1 GH1 AIP
6 gigantism 31.4 PRL GH1 AIP
7 goiter 31.1 TRH SST PRL IGF1
8 acth-secreting pituitary adenoma 31.1 USP8 TBX19 SSTR5 SSTR2 SST PRL
9 diabetes insipidus 31.0 PRL POMC GH1 CRH
10 intracranial hypertension, idiopathic 30.9 POMC IGF1 GH1
11 fibrous dysplasia 30.9 SST PRL IGF1 GH1
12 familial isolated pituitary adenoma 30.8 MEN1 AIP
13 pituitary tumors 30.7 SSTR5 SST PRL POMC MEN1 IGF1
14 chromophobe adenoma 30.7 TRH PRL POMC GH1
15 empty sella syndrome 30.7 TRH PRL POMC IGF1 GH1
16 lymphocytic hypophysitis 30.6 TBX19 POMC GH1
17 hypopituitarism 30.6 TRH TBX19 PRL POMC IGF1 GHR
18 chiasmal syndrome 30.6 SST POMC
19 galactorrhea 30.6 PRL IGF1 DRD2
20 pituitary hormone deficiency, combined, 2 30.6 TRH PRL POMC IGF1 GHR GH1
21 mccune-albright syndrome 30.6 SST PRL MEN1 IGF1 GHR GH1
22 hypothyroidism, congenital, nongoitrous, 4 30.6 PRL POMC GH1
23 sexual disorder 30.5 PRL POMC IGF1 DRD2
24 gynecomastia 30.5 PRL POMC DRD2
25 neuroendocrine carcinoma 30.5 SST S100B MEN1
26 isolated growth hormone deficiency 30.4 POMC IGF1 GHR GH1
27 gangliocytoma 30.4 PRL POMC CRH
28 neuroendocrine tumor 30.4 SSTR2 SST POMC MEN1
29 adenoma 30.4 USP8 TRH SSTR5 SSTR2 SST PRL
30 polycystic ovary syndrome 30.3 PRL POMC IGF1 GH1
31 acth-dependent cushing syndrome 30.3 USP8 PRL POMC CRH
32 uremia 30.3 MEN1 GHR GH1
33 insulin-like growth factor i 30.3 PRL IGF1 GHR GH1
34 hyperprolactinemia 30.3 TRH SST PRL POMC IGF1 GH1
35 paraganglioma 30.3 SST S100B MEN1
36 pituitary apoplexy 30.2 TRH SST PRL POMC MEN1 IGF1
37 hypothyroidism 30.2 TRH SST PRL POMC IGF1 GHR
38 craniopharyngioma 30.2 TRH PRL IGF1 GH1
39 hydrocephalus 30.2 SST S100B PRL IGF1
40 thyroid gland medullary carcinoma 30.2 SSTR5 SSTR2 SST MEN1
41 psychotic disorder 30.2 S100B PRL MIR24-1 DRD2
42 amenorrhea 30.2 TRH PRL POMC IGF1 CRH
43 hyperthyroidism 30.2 TRH SST PRL POMC IGF1 GH1
44 islet cell tumor 30.2 SSTR2 SST MEN1 IGF1 GH1
45 anxiety 30.1 PRL POMC DRD2 CRH
46 hypoglycemia 30.1 SST PRL POMC IGF1 GHR GH1
47 thyroid carcinoma, familial medullary 30.0 SSTR5 SSTR2 SST POMC MEN1
48 migraine with or without aura 1 30.0 S100B PRL POMC DRD2 CRH
49 acth deficiency, isolated 29.9 TRH TBX19 PRL POMC CRH
50 multiple endocrine neoplasia, type i 29.9 SST PRL POMC MIR24-1 MEN1 AIP

Graphical network of the top 20 diseases related to Functioning Pituitary Adenoma:



Diseases related to Functioning Pituitary Adenoma

Symptoms & Phenotypes for Functioning Pituitary Adenoma

MGI Mouse Phenotypes related to Functioning Pituitary Adenoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.2 AIP CRH DRD2 GHR IGF1 MEN1
2 endocrine/exocrine gland MP:0005379 10.18 AIP CDK6 CRH DRD2 GHR IGF1
3 growth/size/body region MP:0005378 10.18 AIP CDK6 CRH DRD2 GHR IGF1
4 cardiovascular system MP:0005385 10.13 AIP CDK6 DRD2 GHR IGF1 MEN1
5 integument MP:0010771 9.91 AIP CRH DRD2 GHR IGF1 POMC
6 liver/biliary system MP:0005370 9.81 AIP CDK6 CRH DRD2 GHR MEN1
7 neoplasm MP:0002006 9.5 AIP CDK6 DRD2 IGF1 MEN1 POMC
8 nervous system MP:0003631 9.4 CDK6 CRH DRD2 GHR IGF1 MEN1

Drugs & Therapeutics for Functioning Pituitary Adenoma

Drugs for Functioning Pituitary Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 84)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Octreotide Approved, Investigational Phase 4 83150-76-9 383414 6400441
2
Metformin Approved Phase 4 657-24-9 14219 4091
3
Liraglutide Approved Phase 4 204656-20-2 44147092
4
Pasireotide Approved Phase 4 396091-73-9 9941444
5
Dopamine Approved Phase 4 51-61-6, 62-31-7 681
6
Cabergoline Approved Phase 4 81409-90-7 54746
7
Somatostatin Approved, Investigational Phase 4 38916-34-6, 51110-01-1 53481605
8
Lactitol Approved, Investigational Phase 4 585-88-6, 585-86-4 493591
9 Hypoglycemic Agents Phase 4
10 Insulin, Globin Zinc Phase 4
11 insulin Phase 4
12 Dipeptidyl-Peptidase IV Inhibitors Phase 4
13
protease inhibitors Phase 4
14 Sitagliptin Phosphate Phase 4
15 HIV Protease Inhibitors Phase 4
16 Incretins Phase 4
17 Hormone Antagonists Phase 4
18 Dopamine Agents Phase 4
19 Dopamine agonists Phase 4
20 Antiparkinson Agents Phase 4
21 Neurotransmitter Agents Phase 4
22
Ketoconazole Approved, Investigational Phase 3 65277-42-1 47576
23 Orange Approved Phase 3
24
lanreotide Approved Phase 3 108736-35-2
25 Angiopeptin Phase 3
26 Pharmaceutical Solutions Phase 3
27
Gefitinib Approved, Investigational Phase 2 184475-35-2 123631
28
Bexarotene Approved, Investigational Phase 1, Phase 2 153559-49-0 82146
29
Sodium citrate Approved, Investigational Phase 2 68-04-2
30
Vorinostat Approved, Investigational Phase 2 149647-78-9 5311
31
Prednisolone phosphate Approved, Vet_approved Phase 2 302-25-0
32
Methylprednisolone Approved, Vet_approved Phase 2 83-43-2 6741
33
Methylprednisolone hemisuccinate Approved Phase 2 2921-57-5
34
Prednisolone Approved, Vet_approved Phase 2 50-24-8 5755
35 Prednisolone acetate Approved, Vet_approved Phase 2 52-21-1
36
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
37
Citric acid Approved, Nutraceutical, Vet_approved Phase 2 77-92-9 311
38
Enclomiphene Investigational Phase 2 15690-57-0
39
Prednisolone hemisuccinate Experimental Phase 2 2920-86-7
40
Maleic acid Experimental, Investigational Phase 2 110-17-8, 110-16-7 444972
41 Citrate Phase 2
42 Estrogen Antagonists Phase 2
43 Estrogen Receptor Antagonists Phase 2
44 Clomiphene Phase 2
45 Estrogen Receptor Modulators Phase 2
46 Estrogens Phase 2
47 Zuclomiphene Phase 2
48 Antineoplastic Agents, Hormonal Phase 2
49 Antiemetics Phase 2
50 Gastrointestinal Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 57)
# Name Status NCT ID Phase Drugs
1 Long-term (up to 3 Years) Clinical and Hormonal Outcomes in Acromegalic Patients With Treated Surgery With or Without Long Acting Somatostatin Analogues: Open-labeled, Prospective, Parallel Group Study Unknown status NCT02427295 Phase 4 Sandostatin (Octreotide Acetate)
2 Adipokine Profile in Patients With Cushing's Disease on Pasireotide Treatment: Correlation With Disease Activity, Insulin Sensitivity and Secretion Parameters Completed NCT03080181 Phase 4 Pasireotide 0.6 MG/ML
3 A Multi-center, Randomized, Open-label, Phase IV Study to Investigate the Management of Pasireotide-induced Hyperglycemia With Incretin Based Therapy or Insulin in Adult Patients With Cushing's Disease or Acromegaly Completed NCT02060383 Phase 4 Pasireotide s.c.;Sitagliptin;Liraglutide;Insulin;Pasireotide LAR;Metformin
4 An Open Label, Multi-center Pasireotide Roll-over Protocol for Patients Who Have Completed a Previous Novartis-sponsored Pasireotide Study and Are Judged by the Investigator to Benefit From Continued Pasireotide Treatment Active, not recruiting NCT01794793 Phase 4 Pasireotide;Cabergoline;Pasireotide
5 A Randomized, Double-blind Study to Assess the Safety and Efficacy of Different Dose Levels of Pasireotide (SOM230) Subcutaneous (sc) Over a 6 Month Treatment Period in Patients With de Novo, Persistent or Recurrent Cushing's Disease Completed NCT00434148 Phase 3 Pasireotide
6 Compassionate Use Protocol for the Administration of CORLUX® (Mifepristone) in the Treatment of the Signs and Symptoms of Endogenous Cushing's Syndrome Completed NCT01371565 Phase 3 Mifepristone
7 Study of Cabergoline in Treatment of Corticotroph Pituitary Tumor Completed NCT00889525 Phase 3 Cabergoline
8 A Randomized, Double-blind, Multicenter, Phase III Study to Evaluate the Efficacy and Safety of Pasireotide LAR in Patients With Cushing's Disease Completed NCT01374906 Phase 3 pasireotide LAR;SOM230 LAR 30 mg;SOM230 LAR 10 mg
9 An Open-label, Multi-center, Expanded Access Study of Pasireotide s.c. in Patients With Cushing's Disease (Seascape). Completed NCT01582061 Phase 3 Pasireotide sub-cutaneous
10 Prevention of Metabolic Complications of Glucocorticoid Excess - a Randomised, Doubleblind,Placebo Controlled Study Completed NCT01319994 Phase 2, Phase 3 Metformin;Placebo
11 Phase III, Multi-center, Double-blind, Randomized Withdrawal Study of LCI699 Following a 24 Week, Single-arm, Open-label Dose Titration and Treatment Period to Evaluate the Safety and Efficacy of LCI699 for the Treatment of Patients With Cushing's Disease Completed NCT02180217 Phase 3 osilodrostat;LCI699 matching placebo
12 An Open-label Extension Study of Levoketoconazole (2S,4R-ketoconazole) in the Treatment of Endogenous Cushing's Syndrome Recruiting NCT03621280 Phase 3 Levoketoconazole
13 A Phase III, Multi-center, Randomized, Double-blind, 48 Week Study With an Initial 12 Week Placebo-controlled Period to Evaluate the Safety and Efficacy of Osilodrostat in Patients With Cushing's Disease Active, not recruiting NCT02697734 Phase 3 osilodrostat;osilodrostat Placebo
14 Multicenter Evaluation of the Effect of Upfront Radiosurgery on Residual Growth Hormone-secreting Pituitary Adenoma From an Endocrinological Point of View (MERGE Study): a Randomized, Phase 3 Trial Not yet recruiting NCT03439709 Phase 3 Lanreotide 60Mg Solution for Injection
15 An Open-label Study of the Safety, Pharmacokinetics and Pharmacodynamics of Mifepristone in Children With Refractory Cushing's Disease Withdrawn NCT01925092 Phase 3 mifepristone
16 Targeted Therapy With Gefitinib in Patients With USP8-mutated Cushing's Disease Unknown status NCT02484755 Phase 2 Gefitinib
17 Preoperative Bexarotene Treatment for Cushing's Disease Unknown status NCT00845351 Phase 1, Phase 2 Bexarotene
18 Extension Study to Assess the Safety and Efficacy of Pasireotide in Patients With Cushing's Disease Completed NCT00171951 Phase 2 Pasireotide
19 An Open-Label, Single Arm, Phase II Study to Evaluate the Efficacy and Safety of Pasireotide LAR on the Treatment of Patients With Clinically Non-Functioning Pituitary Adenoma Completed NCT01283542 Phase 2 Pasireotide LAR
20 A Multicenter, Open Label Study to Assess the Safety and Efficacy of 600 µg SOM230, Administered Subcutaneously, b.i.d. in Patients With Cushing's Disease Completed NCT00088608 Phase 2 SOM230 s.c.
21 Extension to a Multi-center, Randomized, Crossover, Open Label, Dose Finding Study to Compare the Safety, Efficacy, and Pharmacokinetics/Pharmacodynamics (PK/PD) Relationship of Multiple Doses of Pasireotide (SOM230) (200, 400, and 600 μg Bid) and Doses of Open Label Sandostatin® (SMS) (100 μg Tid) in Acromegalic Patients Completed NCT00171730 Phase 2 Pasireotide
22 A Proof of Concept, Open-label, Forced Titration, Multi-center Study to Assess the Safety/Tolerability and Efficacy of 10-weeks Treatment of LCI699 Followed by a 12 - Week Treatment Period of LCI699 in Patients With Cushing's Disease Completed NCT01331239 Phase 2 LCI699
23 Clomiphene Citrate for Treatment of Acromegaly Not Controlled by Conventional Therapies Completed NCT02274311 Phase 2 Clomiphene Citrate
24 A Phase II Trial to Assess the Efficacy and Safety of Pasireotide s.c. Alone or in Combination With Cabergoline in Patients With Cushing's Disease Completed NCT01915303 Phase 2 Pasireotide with or without cabergoline
25 A Phase II, Multicenter, Open-label, Non-comparative Study to Evaluate the Pharmacokinetics, Pharmacodynamics, and Tolerability of Osilodrostat in Children and Adolescent Patients With Cushing's Disease Recruiting NCT03708900 Phase 2 LCI699
26 A Phase 2 Multicenter Study of Seliciclib (R-roscovitine) for Cushing Disease Recruiting NCT03774446 Phase 2 Seliciclib
27 The Effect of Vorinostat on ACTH Producing Pituitary Adenomas in Cushing s Disease Recruiting NCT04339751 Phase 2 Vorinostat
28 Targeting Iatrogenic Cushing's Syndrome With 11β-hydroxysteroid Dehydrogenase Type 1 Inhibition (TICSI) Recruiting NCT03111810 Phase 2 AZD4017 and prednisolone;Placebo Oral Tablet and prednisolone
29 An Open Label, Multicenter Study Evaluating the Safety and Efficacy of Short Term (6 Weeks) Rosiglitazone Treatment in Patient's With Cushing's Disease Terminated NCT00612066 Phase 2 rosiglitazone maleate
30 Treatment of Pituitary Cushing Disease With a Selective CDK Inhibitor, R-roscovitine Terminated NCT02160730 Phase 2 R-roscovitine
31 Exploratory Phase 2 Study of Farletuzumab in Resectable Non-functioning Pituitary Adenoma Withdrawn NCT01203618 Phase 2 Farletuzumab
32 A Phase 1, Single Dose, Open-Label Study to Investigate the Safety and Efficacy of OTL38 Injection for Intraoperative Imaging of Folate Receptor-alpha Positive Pituitary Adenoma Terminated NCT02629549 Phase 1 OTL38
33 A Pilot Study of Rosiglitazone in the Treatment of GH Secreting Pituitary Adenomas Unknown status NCT03309319 Rosiglitazone
34 Interdisciplinary Pituitary Disorders Centre of Excellence: Assessment of Patient Education Tools Unknown status NCT01775332
35 Etat de santé Des Patients Suivis Pour Une Maladie de Cushing Dans la région Grand-Ouest de 1990 à 2015 Unknown status NCT03297892
36 Cognitive Sequels of Cushing Syndrome Unknown status NCT02603653
37 Characterization of Receptors Present in Non-functioning Pituitary Macroadenomas by Reverse Transcriptase- Polymerase Chain Reaction (RT-PCR) Unknown status NCT00852501
38 Investigation of Prevalence and Clinical Effects of Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene Mutations With DNA Sequence Analysis in Acromegaly Patients in Turkey Unknown status NCT01902420
39 Characteristics of Glycemic Fluctuations in Newly Diagnosed Growth Hormone-Secreting Pituitary Adenoma and Cushing Syndrome Subjects Completed NCT02574793
40 Cognition, Steroids, and Imaging in Cushings Disease Completed NCT00081341
41 The Factors Associated With the Recurrence in Patients With Cushing Disease Completed NCT02233335
42 National Swedish Study in Cushing´s Disease Incidence and Outcomes Completed NCT02350153
43 Rhinological Outcomes in Endonasal Pituitary Surgery: A Multi-Center Observational Cohort Study Completed NCT01504399
44 Evolution of the Metabolic, Cardiovascular, Bone Complications and of the Quality of Life in Cushing's Disease Completed NCT02568982
45 Seoul National University Pituitary Disease Cohort Study Recruiting NCT03474601
46 Discriminant Capacity and Thresholds of Salivary Cortisol in Chemiluminescence in the Diagnosis of Hypercorticisms: Phase III Diagnostic Evaluation Study Recruiting NCT03974789
47 Modulating the Glucose-dependent Insulinotropic Polypeptide (GIP) System in Patients With Acromegaly Due to a Pituitary Tumor Recruiting NCT03807076
48 Non-interventional Study for the Generation of Long Term Safety and Efficacy Data of Pasireotide s.c. in Patients With Cushing's Disease (Post-Authorization Safety Study) Recruiting NCT02310269 SOM230
49 Prospective Observational Study of Diagnostic Yield in Cushing's Disease Using Deep Learning Based Denoising MRI Recruiting NCT04121988
50 Impact of [11C]-Methionine PET/MRI in the Detection of Pituitary Adenomas Secreting ACTH and Causing Cushing's Disease Recruiting NCT03346954

Search NIH Clinical Center for Functioning Pituitary Adenoma

Genetic Tests for Functioning Pituitary Adenoma

Anatomical Context for Functioning Pituitary Adenoma

MalaCards organs/tissues related to Functioning Pituitary Adenoma:

40
Pituitary, Bone, Brain, Testes, Lung, Thyroid, Ovary

Publications for Functioning Pituitary Adenoma

Articles related to Functioning Pituitary Adenoma:

(show top 50) (show all 216)
# Title Authors PMID Year
1
Correction to: Quality of care evaluation in non-functioning pituitary adenoma with chiasm compression: visual outcomes and timing of intervention clinical recommendations based on a systematic literature review and cohort study. 61
32567033 2020
2
Quality of care evaluation in non-functioning pituitary adenoma with chiasm compression: visual outcomes and timing of intervention clinical recommendations based on a systematic literature review and cohort study. 61
32419072 2020
3
Comparative analysis of rhinologic outcomes in Cushing disease and non-functioning pituitary adenoma in patients submitted to endoscopic endonasal transsphenoidal surgery. 61
32346754 2020
4
Non-functioning pituitary adenomas and pregnancy: one-center experience and review of the literature. 61
32267360 2020
5
Cut-off values for sufficient cortisol response to low dose Short Synacthen Test after surgery for non-functioning pituitary adenoma. 61
31907611 2020
6
An aggressive functioning pituitary adenoma treated with peptide receptor radionuclide therapy. 61
31741022 2020
7
Integrated analysis of DNA methylation and mRNA expression profiles to identify key genes involved in the regrowth of clinically non-functioning pituitary adenoma. 61
32015217 2020
8
Preoperative growth hormone (GH) peak values during a GH releasing peptide-2 test reflect the severity of hypopituitarism and the postoperative recovery of GH secretion in patients with non-functioning pituitary adenomas. 61
31776295 2020
9
Giant Non-Functioning Pituitary Adenoma: Clinical Characteristics and Therapeutic Outcomes. 61
31896156 2020
10
Giant Non-Functioning Pituitary Adenoma: Clinical Characteristics and Therapeutic Outcomes. 61
31931533 2020
11
Identification of key genes in invasive clinically non-functioning pituitary adenoma by integrating analysis of DNA methylation and mRNA expression profiles. 61
31796052 2019
12
T5224, RSPO2 and AZD5363 are novel drugs against functional pituitary adenoma. 61
31655798 2019
13
NON-FUNCTIONAL PITUITARY TUMORS: A MISLEADING PRESENTATION OF AN INTRASELLAR PLASMACYTOMA. 61
32377251 2019
14
Functioning Pituitary Adenoma with Xanthogranulomatous Features: Review of Literature and Case Report. 61
31534885 2019
15
Identification of CDK6 and RHOU in Serum Exosome as Biomarkers for the Invasiveness of Non-functioning Pituitary Adenoma. 61
31601299 2019
16
Cavernous sinus haemangioma with intrasellar extension mimicking non-functioning pituitary adenoma - A case report and review of literature. 61
31406488 2019
17
The benefit and risk of stereotactic radiosurgery for prolactinomas: an international multicenter cohort study. 61
31374549 2019
18
Significance of Elevated HMGB1 Expression in Pituitary Apoplexy. 61
31366550 2019
19
Unexpected concomitant pituitary adenoma and suprasellar meningioma: a case report and review of the literature. 61
31204511 2019
20
Autoimmune thyroid diseases are more common in patients with prolactinomas: a retrospective case-control study in an Italian cohort. 61
30406929 2019
21
Endocrinological Outcome of Endoscopic Transsphenoidal Surgery for Functioning and Non-Functioning Pituitary Adenoma. 61
31303851 2019
22
Pre-operative MRI predictors of hormonal remission status post pituitary adenoma resection. 61
30731423 2019
23
Predicting the regrowth of clinically non-functioning pituitary adenoma with a statistical model. 61
31109334 2019
24
The burden of disease for pituitary patients. 61
31405752 2019
25
Quality of Life but not Cognition is Impacted by Radiotherapy in Patients with Non-Functioning Pituitary Adenoma. 61
30861564 2019
26
Incidence rate and risk factors of early repolarization in patients with growth hormone-secreting pituitary adenoma: a cohort study. 61
30643415 2019
27
Intractable Rathke's cleft cyst hidden behind co-existing giant pituitary adenoma - Case report. 61
30610983 2019
28
Genome-wide identification of lncRNAs and mRNAs differentially expressed in non-functioning pituitary adenoma and construction of an lncRNA-mRNA co-expression network. 61
30504132 2019
29
A two‑circRNA signature predicts tumour recurrence in clinical non‑functioning pituitary adenoma. 61
30542712 2019
30
Endocrinological Outcomes of Intraoperative MRI-Guided Endoscopic Transsphenoidal Surgery for Non-Functioning Pituitary Adenoma. 61
30649793 2019
31
FGFR2 gene polymorphism rs2981582 is associated with non-functioning pituitary adenomas in Chinese Han population: a case-control study. 61
30206133 2018
32
Recurrence in silent corticotroph adenomas after primary treatment: A systematic review and meta-analysis. 61
30590584 2018
33
Spindle cell oncocytoma of the neurohypophysis with metastasis to the sphenoparietal sinus and immunohistochemical negativity for S100 and epithelial membrane antigen (EMA). 61
30431381 2018
34
Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement 61
30299891 2018
35
Non-invasive radiomics approach potentially predicts non-functioning pituitary adenomas subtypes before surgery. 61
29572634 2018
36
Postoperative growth hormone dynamics in clinically nonfunctioning pituitary adenoma. 61
29910227 2018
37
Comorbidities in patients with non-functioning pituitary adenoma: influence of long-term growth hormone replacement. 61
30049813 2018
38
Data of phosphoproteomic analysis of non-functioning pituitary adenoma. 61
29900237 2018
39
UPDATE ON THE CLINICOPATHOLOGY OF PITUITARY ADENOMAS. 61
29498920 2018
40
Mid-term prognosis of non-functioning pituitary adenomas with high proliferative potential: really an aggressive variant? 61
29318507 2018
41
How non-functioning pituitary adenomas can affect health-related quality of life: a conceptual model and literature review. 61
29302835 2018
42
Effects of active acromegaly on bone mRNA and microRNA expression patterns. 61
29374071 2018
43
Mortality in patients with non-functioning pituitary adenoma. 61
29344906 2018
44
Spectrum of Pituitary disorders: A retrospective study from Basrah, Iraq. 61
30026929 2018
45
Interpretation of Serum Gonadotropin Levels in Hyperprolactinaemia. 61
29660734 2018
46
Pituitary Carcinoma in a Patient with an SDHB Mutation. 61
28284009 2017
47
Amelanotic melanocytoma of the sella mimicking pituitary adenoma. 61
28853696 2017
48
Higher glucocorticoid replacement doses are associated with increased mortality in patients with pituitary adenoma. 61
28596421 2017
49
In-frame seven amino-acid duplication in AIP arose over the last 3000 years, disrupts protein interaction and stability and is associated with gigantism. 61
28634279 2017
50
Prevalence, Clinical Features, and Natural History of Incidental Clinically Non-Functioning Pituitary Adenomas. 61
28759937 2017

Variations for Functioning Pituitary Adenoma

Expression for Functioning Pituitary Adenoma

Search GEO for disease gene expression data for Functioning Pituitary Adenoma.

Pathways for Functioning Pituitary Adenoma

Pathways related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.94 TRH SSTR5 SSTR2 SST PRL POMC
2
Show member pathways
12.57 USP8 POMC MEN1 CRH CDK6 AIP
3 11.99 SSTR5 SSTR2 SST POMC DRD2
4
Show member pathways
11.97 POMC MIR24-1 IGF1 GH1
5
Show member pathways
11.76 SSTR5 SSTR2 SST POMC IGF1 GHR
6 11.62 TBX19 POMC CRH
7 11.45 IGF1 GHR GH1
8
Show member pathways
11.16 PRL GHR GH1
9 10.63 PRL POMC DRD2
10 10.28 POMC CRH

GO Terms for Functioning Pituitary Adenoma

Cellular components related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.81 TRH SST S100B PRL POMC IGF1
2 extracellular space GO:0005615 9.32 SST S100B PRL POMC MIR93 MIR24-1
3 growth hormone receptor complex GO:0070195 8.96 GHR GH1

Biological processes related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 10.09 TRH SSTR5 SSTR2 PRL POMC IGF1
2 G protein-coupled receptor signaling pathway GO:0007186 10 TRH SSTR5 SSTR2 SST POMC DRD2
3 cell-cell signaling GO:0007267 9.81 TRH SST POMC DRD2
4 neuropeptide signaling pathway GO:0007218 9.74 SSTR5 SSTR2 POMC
5 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.72 IGF1 GHR GH1
6 positive regulation of tyrosine phosphorylation of STAT protein GO:0042531 9.65 IGF1 GHR GH1
7 insulin-like growth factor receptor signaling pathway GO:0048009 9.56 IGF1 GHR
8 positive regulation of insulin-like growth factor receptor signaling pathway GO:0043568 9.54 IGF1 GH1
9 growth hormone receptor signaling pathway GO:0060396 9.52 GHR GH1
10 positive regulation of multicellular organism growth GO:0040018 9.5 GHR GH1 DRD2
11 peristalsis GO:0030432 9.49 SSTR2 DRD2
12 positive regulation of JAK-STAT cascade GO:0046427 9.43 PRL GHR GH1
13 somatostatin signaling pathway GO:0038170 9.4 SSTR5 SSTR2
14 hormone-mediated apoptotic signaling pathway GO:0008628 9.37 SST CRH
15 regulation of multicellular organism growth GO:0040014 9.33 PRL IGF1 GHR
16 negative regulation of cell proliferation GO:0008285 9.17 SSTR5 SSTR2 SST MIR93 MEN1 DRD2
17 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.13 PRL GHR GH1

Molecular functions related to Functioning Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.17 TRH SST PRL POMC IGF1 GH1
2 somatostatin receptor activity GO:0004994 9.16 SSTR5 SSTR2
3 prolactin receptor binding GO:0005148 8.96 PRL GH1

Sources for Functioning Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
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