MCID: FNC003
MIFTS: 22

Functionless Pituitary Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Functionless Pituitary Adenoma

MalaCards integrated aliases for Functionless Pituitary Adenoma:

Name: Functionless Pituitary Adenoma 12
Non-Secretory Adenoma of the Pituitary Gland 12
Non-Functioning Neoplasm of the Pituitary 12
Non-Functioning Pituitary Gland Neoplasm 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5715
NCIt 50 C4009 C4348
SNOMED-CT 68 254962005
UMLS 73 C0338078

Summaries for Functionless Pituitary Adenoma

MalaCards based summary : Functionless Pituitary Adenoma, also known as non-secretory adenoma of the pituitary gland, is related to esophagus squamous cell carcinoma and gastric cardia adenocarcinoma. An important gene associated with Functionless Pituitary Adenoma is MEG3 (Maternally Expressed 3
Maternally Expressed Gene 3 (MEG3),which is specifically associated with clinically non-functioning pituitary adenomas of a gonadotroph lineage. Complimentary DNA-RDA revealed that MEG3 mRNA is present in the normal human pituitary but absent in clinically non-functioning tumors. MEG3 functions to suppress tumor cell growth,increase protein expression of the tumor suppressor p53,and selectively activate p53 target genes. Interestingly,MEG3 does not encode a protein but a non-coding RNA.
Dysfunction Pattern: Regulation [down-regulated]), and among its related pathways/superpathways is LncRNA-mediated mechanisms of therapeutic resistance. The drugs Dopamine and Cabergoline have been mentioned in the context of this disorder. Affiliated tissues include pituitary and brain.

Related Diseases for Functionless Pituitary Adenoma

Graphical network of the top 20 diseases related to Functionless Pituitary Adenoma:



Diseases related to Functionless Pituitary Adenoma

Symptoms & Phenotypes for Functionless Pituitary Adenoma

Drugs & Therapeutics for Functionless Pituitary Adenoma

Drugs for Functionless Pituitary Adenoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 25)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dopamine Approved Phase 3,Phase 2 51-61-6, 62-31-7 681
2
Cabergoline Approved Phase 3,Phase 2 81409-90-7 54746
3
Octreotide Approved, Investigational Phase 3,Phase 1 83150-76-9 383414 6400441
4
Somatostatin Approved, Investigational Phase 2, Phase 3,Phase 1 38916-34-6, 51110-01-1 53481605
5 Dopamine agonists Phase 3,Phase 2
6 Gastrointestinal Agents Phase 3,Phase 1
7 Neurotransmitter Agents Phase 3,Phase 2
8 Hormone Antagonists Phase 2, Phase 3
9 Hormones Phase 2, Phase 3,Phase 1
10 Dopamine Agents Phase 3,Phase 2
11 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
12 Edotreotide Phase 3,Phase 1
13 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3
14 Protective Agents Phase 2, Phase 3,Phase 3
15 Antiparkinson Agents Phase 3,Phase 2
16 Radiopharmaceuticals Phase 3,Phase 1
17 Autonomic Agents Phase 2, Phase 3,Phase 3
18 Antineoplastic Agents, Hormonal Phase 3,Phase 1
19
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
20
Maleic acid Experimental Phase 2 110-16-7 444266
21 Adrenocorticotropic Hormone Phase 2
22 Hypoglycemic Agents Phase 2
23 Pancreatic Polypeptide Investigational Phase 1 59763-91-6
24
Menthol Approved 2216-51-5 16666
25 Calcium, Dietary

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Cabergoline in Nonfunctioning Pituitary Adenomas Completed NCT03271918 Phase 3 Cabergoline
2 Response to Cabergoline and Pasireotide in Non-functioning Pituitary Adenomas and Resistant Prolactinomas Completed NCT01620138 Phase 2, Phase 3 Pasireotide;cabergoline
3 Dopamine Agonist Treatment of Non-functioning Pituitary Adenomas Recruiting NCT02288962 Phase 3 cabergoline
4 Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Recruiting NCT02419664 Phase 3
5 Evaluate the Efficacy and Safety of Pasireotide LAR on the Treatment of Patients With Clinically Non-Functioning Pituitary Adenoma. Completed NCT01283542 Phase 2 Pasireotide LAR
6 Pasireotide LAR Therapy of Silent Corticotroph Pituitary Tumors Recruiting NCT02749227 Phase 2 Pasireotide LAR
7 Rosiglitazone in Treating Patients With Pituitary Tumors Terminated NCT00616642 Phase 2 rosiglitazone maleate
8 Exploratory Study of Farletuzumab to Treat Resectable, Non-functioning Pituitary Adenomas Withdrawn NCT01203618 Phase 2 Farletuzumab
9 Temozolomide in Treating Patients With Invasive Pituitary Tumors Withdrawn NCT00601289 Phase 2 temozolomide
10 Antineoplaston Therapy in Treating Patients With Neuroendocrine Tumor That Is Metastatic or Unlikely to Respond to Surgery or Radiation Therapy Withdrawn NCT00003514 Phase 2 antineoplaston A10;antineoplaston AS2-1
11 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
12 Characterization of Receptors in Non-functioning Pituitary Macroadenomas Unknown status NCT00852501
13 Calcium Homeostasis in Acromegaly: Effect of Surgical/Medical Treatment and Comparison With Nonfunctioning Pituitary Tumors Completed NCT01568359
14 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
15 Comparison of Propofol Requirement Between Patients With Pituitary Somatotroph Tumor and With Nonfunctioning Pituitary Tumor in Transsphenoidal Pituitary Surgery Under Total Intravenous Anesthesia Recruiting NCT03465423
16 Prospective Study of Clinically Nonfunctioning Pituitary Adenomas Recruiting NCT01556230
17 Predictive Factors of Recurrence of Non Functioning Pituitary Adenomas : a Retrospective Study of 220 Patients in the Reims University Hospital, France Recruiting NCT02803697
18 Transsphenoidal Extent of Resection Study Recruiting NCT02357498 Not Applicable
19 Seoul National University Pituitary Disease Cohort Study Recruiting NCT03474601

Search NIH Clinical Center for Functionless Pituitary Adenoma

Genetic Tests for Functionless Pituitary Adenoma

Anatomical Context for Functionless Pituitary Adenoma

MalaCards organs/tissues related to Functionless Pituitary Adenoma:

41
Pituitary, Brain

Publications for Functionless Pituitary Adenoma

Variations for Functionless Pituitary Adenoma

Expression for Functionless Pituitary Adenoma

Search GEO for disease gene expression data for Functionless Pituitary Adenoma.

Pathways for Functionless Pituitary Adenoma

Pathways related to Functionless Pituitary Adenoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 9.7 HOTAIR MEG3

GO Terms for Functionless Pituitary Adenoma

Sources for Functionless Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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