MCID: FNC003
MIFTS: 23

Functionless Pituitary Adenoma

Categories: Cancer diseases, Endocrine diseases

Aliases & Classifications for Functionless Pituitary Adenoma

MalaCards integrated aliases for Functionless Pituitary Adenoma:

Name: Functionless Pituitary Adenoma 12 15
Non-Secretory Adenoma of the Pituitary Gland 12
Non-Functioning Neoplasm of the Pituitary 12
Non-Functioning Pituitary Gland Neoplasm 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5715
NCIt 50 C4009
SNOMED-CT 67 254962005
UMLS 70 C0338078

Summaries for Functionless Pituitary Adenoma

MalaCards based summary : Functionless Pituitary Adenoma, also known as non-secretory adenoma of the pituitary gland, is related to esophagus squamous cell carcinoma and ovarian epithelial cancer. An important gene associated with Functionless Pituitary Adenoma is HOTAIR (HOX Transcript Antisense RNA), and among its related pathways/superpathways are Peptide ligand-binding receptors and Relaxin signaling pathway. Affiliated tissues include pituitary, and related phenotype is renal/urinary system.

Related Diseases for Functionless Pituitary Adenoma

Diseases related to Functionless Pituitary Adenoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 113)
# Related Disease Score Top Affiliating Genes
1 esophagus squamous cell carcinoma 10.2 MEG3 HOTAIR
2 ovarian epithelial cancer 10.2 MEG3 HOTAIR
3 gastric cardia adenocarcinoma 10.2 MEG3 HOTAIR
4 thyroid cancer, nonmedullary, 1 10.2 MEG3 HOTAIR
5 acalculous cholecystitis 10.1 CCKAR CCK
6 cholecystitis 10.1 CCKAR CCK
7 pancreatic endocrine carcinoma 10.1 SST MEG3
8 exocrine pancreatic insufficiency 10.0 CCKAR CCK
9 carcinoid syndrome 10.0 SST IGF1
10 biliary dyskinesia 10.0 SST CCK
11 cholecystolithiasis 10.0 SST CCK
12 bile acid malabsorption, primary 10.0 SST CCK
13 duodenogastric reflux 10.0 SST CCK
14 functional gastric disease 10.0 SST CCK
15 pituitary adenoma 1, multiple types 10.0 SST IGF1
16 dumping syndrome 10.0 SST CCK
17 articulation disorder 10.0 SST CCK
18 fibrous dysplasia 9.9 SST IGF1
19 osteogenic sarcoma 9.9 MEG3 IGF1 HOTAIR
20 opioid addiction 9.9 CCKBR CCKAR CCK
21 pyloric stenosis 9.9 SST IGF1
22 fasting hypoglycemia 9.9 POMC IGF1
23 sheehan syndrome 9.9 POMC IGF1
24 nasal cavity adenocarcinoma 9.9 POMC CCK
25 empty sella syndrome 9.9 POMC IGF1
26 intracranial hypertension, idiopathic 9.9 POMC IGF1
27 opioid abuse 9.9 POMC CCK
28 bronchial adenomas/carcinoids childhood 9.9 SST POMC
29 gastroparesis 9.9 SST CCK
30 chiasmal syndrome 9.8 SST POMC
31 ectopic cushing syndrome 9.8 SST POMC
32 opiate dependence 9.8 POMC IGF1
33 tsh producing pituitary tumor 9.8 SST POMC
34 sebaceous gland disease 9.8 POMC IGF1
35 sexual disorder 9.8 POMC IGF1
36 pituitary hormone deficiency, combined, 2 9.8 POMC IGF1
37 colon neuroendocrine neoplasm 9.8 SST POMC
38 adult syndrome 9.8 POMC IGF1
39 pituitary-dependent cushing's disease 9.8 SST POMC
40 nelson syndrome 9.8 SST POMC
41 silver-russell syndrome 1 9.8 MEG3 IGF1
42 central nervous system benign neoplasm 9.8 POMC IGF1
43 pain agnosia 9.8 POMC CCK
44 agnosia 9.8 POMC CCK
45 cholelithiasis 9.8 SST CCKAR CCK
46 meningioma, familial 9.8 SST MEG3 CCKAR
47 myeloma, multiple 9.8 MEG3 IGF1 HOTAIR
48 acute pancreatitis 9.8 SST CCKAR CCK
49 duodenal ulcer 9.8 SST CCK
50 islet cell tumor 9.8 SST IGF1 CCKBR

Graphical network of the top 20 diseases related to Functionless Pituitary Adenoma:



Diseases related to Functionless Pituitary Adenoma

Symptoms & Phenotypes for Functionless Pituitary Adenoma

MGI Mouse Phenotypes related to Functionless Pituitary Adenoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 renal/urinary system MP:0005367 9.02 CCK CCKAR CCKBR IGF1 POMC

Drugs & Therapeutics for Functionless Pituitary Adenoma

Search Clinical Trials , NIH Clinical Center for Functionless Pituitary Adenoma

Genetic Tests for Functionless Pituitary Adenoma

Anatomical Context for Functionless Pituitary Adenoma

MalaCards organs/tissues related to Functionless Pituitary Adenoma:

40
Pituitary

Publications for Functionless Pituitary Adenoma

Articles related to Functionless Pituitary Adenoma:

# Title Authors PMID Year
1
LH and FSH secretion and responses to GnRH and TRH in patients with clinically functionless pituitary adenomas. 61
2116944 1990
2
[Nonfunctional or nonsecreting hypophyseal adenomas. Review of clinical, biological, neuroradiological, developmental and immunohistochemical characteristics. Apropos of 40 cases]. 61
6651074 1983
3
Pituitary function after pituitary apoplexy. 61
707535 1978

Variations for Functionless Pituitary Adenoma

Expression for Functionless Pituitary Adenoma

Search GEO for disease gene expression data for Functionless Pituitary Adenoma.

Pathways for Functionless Pituitary Adenoma

GO Terms for Functionless Pituitary Adenoma

Biological processes related to Functionless Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.72 POMC IGF1 CCKBR CCKAR CCK
2 phospholipase C-activating G protein-coupled receptor signaling pathway GO:0007200 9.37 CCKBR CCKAR
3 G protein-coupled receptor signaling pathway GO:0007186 9.35 SST POMC CCKBR CCKAR CCK
4 response to heat GO:0009408 9.26 SST IGF1
5 digestion GO:0007586 9.16 SST CCK
6 cholecystokinin signaling pathway GO:0038188 8.62 CCKBR CCKAR

Molecular functions related to Functionless Pituitary Adenoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 peptide hormone binding GO:0017046 9.16 CCKBR CCKAR
2 cholecystokinin receptor activity GO:0004951 8.96 CCKBR CCKAR
3 hormone activity GO:0005179 8.92 SST POMC IGF1 CCK

Sources for Functionless Pituitary Adenoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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