MCID: FNG016
MIFTS: 44

Fungal Keratitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Fungal Keratitis

MalaCards integrated aliases for Fungal Keratitis:

Name: Fungal Keratitis 59

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 59  
Rare eye diseases


External Ids:

Orphanet 59 ORPHA519930

Summaries for Fungal Keratitis

CDC : 3 People who have had surgery to replace their corneas are at higher risk of fungal eye infections. More about sources of fungal eye infections.

MalaCards based summary : Fungal Keratitis is related to keratitis, hereditary and rosacea. An important gene associated with Fungal Keratitis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and Degradation of the extracellular matrix. Affiliated tissues include eye, endothelial and neutrophil, and related phenotypes are hematopoietic system and homeostasis/metabolism

Wikipedia : 76 A fungal keratitis is an ''inflammation of the eye''s cornea'' (called keratitis) that results from... more...

Related Diseases for Fungal Keratitis

Diseases related to Fungal Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 92)
# Related Disease Score Top Affiliating Genes
1 keratitis, hereditary 31.4 MMP9 TLR2 TLR4
2 rosacea 29.9 MMP8 MMP9 TLR2
3 endophthalmitis 10.3
4 chromoblastomycosis 10.2 CLEC7A MMP9
5 amaurosis fugax 10.2 MMP8 MMP9
6 haemophilus influenzae 10.2 CLEC7A TLR2
7 periodontitis, chronic 10.2 MMP8 TLR2
8 mycobacterium abscessus 10.2 CLEC7A TLR2
9 coccidioidomycosis 10.2 CLEC7A TLR4
10 vulvovaginal candidiasis 10.2 CLEC7A TLR2
11 primary systemic mycosis 10.2 CLEC7A TLR2
12 periapical periodontitis 10.2 MMP8 TLR2
13 prosthetic joint infection 10.1 TLR2 TLR4
14 trench fever 10.1 TLR2 TLR4
15 inflammatory bowel disease 6 10.1 CD209 TLR4
16 acute cervicitis 10.1 TLR2 TLR4
17 autoimmune inner ear disease 10.1 MMP9 TIMP1
18 periodontosis 10.1 MMP9 TLR4
19 anterior uveitis 10.1 TLR2 TLR4
20 tuberculous meningitis 10.1 MMP9 TLR2
21 suppurative otitis media 10.1 TLR2 TLR4
22 penicilliosis 10.1 TLR2 TLR4
23 myositis fibrosa 10.1 TLR2 TLR4
24 cryptogenic organizing pneumonia 10.1 MMP9 TIMP1
25 conjunctival nevus 10.1 MMP9 TIMP1
26 spondylarthropathy 10.1 TLR2 TLR4
27 neisseria meningitidis infection 10.1 TLR2 TLR4
28 alveolar echinococcosis 10.1 TLR2 TLR4
29 pelvic organ prolapse 10.1 MMP8 MMP9
30 echinococcosis 10.1 TLR2 TLR4
31 septic arthritis 10.1 TLR2 TLR4
32 gingival hypertrophy 10.1 MMP9 TIMP2
33 scrub typhus 10.1 TLR2 TLR4
34 gingival disease 10.1 MMP8 TIMP1
35 irak4 deficiency 10.1 TLR2 TLR4
36 myd88 deficiency 10.1 TLR2 TLR4
37 chronic venous insufficiency 10.1 MMP9 TIMP1
38 middle ear disease 10.1 TLR2 TLR4
39 venous insufficiency 10.1 MMP9 TIMP1
40 common wart 10.0 CD209 CLEC4E CLEC7A
41 bacterial meningitis 10.0 MMP8 MMP9 TLR2
42 gingivitis 10.0 MMP8 MMP9 TLR2
43 central nervous system tuberculosis 10.0 MMP9 TIMP1
44 invasive aspergillosis 10.0 CLEC7A TLR2 TLR4
45 ileitis 10.0 TLR2 TLR4
46 chorioamnionitis 10.0 MMP8 MMP9 TLR4
47 microcystic meningioma 10.0 TIMP1 TIMP2
48 opportunistic mycosis 10.0 CLEC7A TLR2
49 q fever 10.0 TLR2 TLR4
50 fusariosis 10.0

Graphical network of the top 20 diseases related to Fungal Keratitis:



Diseases related to Fungal Keratitis

Symptoms & Phenotypes for Fungal Keratitis

MGI Mouse Phenotypes related to Fungal Keratitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.92 CLEC4E CLEC7A MMP9 TIMP1 TIMP2 TLR2
2 homeostasis/metabolism MP:0005376 9.91 CLEC4E CLEC7A MMP8 MMP9 TIMP1 TIMP2
3 immune system MP:0005387 9.81 CLEC4E CLEC7A MMP8 MMP9 TIMP1 TIMP2
4 neoplasm MP:0002006 9.43 MMP8 MMP9 TIMP1 TLR2 TLR4 TREM1
5 respiratory system MP:0005388 9.02 CLEC7A MMP9 TIMP1 TLR2 TLR4

Drugs & Therapeutics for Fungal Keratitis

Search Clinical Trials , NIH Clinical Center for Fungal Keratitis

Genetic Tests for Fungal Keratitis

Anatomical Context for Fungal Keratitis

MalaCards organs/tissues related to Fungal Keratitis:

41
Eye, Endothelial, Neutrophil, Testes, T Cells, Lung

Publications for Fungal Keratitis

Articles related to Fungal Keratitis:

(show top 50) (show all 443)
# Title Authors Year
1
RISK FACTORS, TREATMENT STRATEGIES, AND OUTCOMES OF ENDOPHTHALMITIS ASSOCIATED WITH SEVERE FUNGAL KERATITIS. ( 29474308 )
2018
2
Fungal keratitis and endophthalmitis after implantation of type 1 keratoprosthesis. ( 29563700 )
2018
3
Corneal Cross-Linking Has No Effect on Matrix Metalloproteinase 9 and 13 Levels During Fungal Keratitis on the Early Stage. ( 29043533 )
2018
4
A novel, tomographic imaging probe for rapid diagnosis of fungal keratitis. ( 29228372 )
2018
5
Application of image recognition-based automatic hyphae detection in fungal keratitis. ( 29285615 )
2018
6
Ophthalmic Econazole Hydrogels for the Treatment of Fungal Keratitis. ( 29305870 )
2018
7
Metagenomic analysis for detecting Fusarium solani in a case of fungal keratitis. ( 29371064 )
2018
8
Comment on: Fungal keratitis: The Aravind Experience. ( 29380807 )
2018
9
Reply to Comment on: Fungal keratitis: The Aravind Experience. ( 29380808 )
2018
10
Microplasma Jet Arrays as a Therapeutic Choice for Fungal Keratitis. ( 29403058 )
2018
11
Ocular surface squamous neoplasia in a setting of fungal keratitis: a rare co-occurrence. ( 29423784 )
2018
12
The Significance of Repeat Cultures in the Treatment of Severe Fungal Keratitis. ( 29438654 )
2018
13
Full-thickness conjunctival flap covering surgery combined with amniotic membrane transplantation for severe fungal keratitis. ( 29456673 )
2018
14
Recognition of Fungal Keratitis in Boston Type I Keratoprosthesis: Importance of Awareness and Novel Identification of Exophiala phaeomuriformis. ( 29474297 )
2018
15
Clinically Significant Enhancement of Voriconazole Efficacy by Moxifloxacin and Gentamicin in Fungal Keratitis. ( 29489515 )
2018
16
Antimicrobial efficacy of corneal cross-linking in vitro and in vivo for Fusarium solani: a potential new treatment for fungal keratitis. ( 29499665 )
2018
17
Tacrolimus interacts with voriconazole to reduce the severity of fungal keratitis by suppressing IFN-related inflammatory responses and concomitant FK506 and voriconazole treatment suppresses fungal keratitis. ( 29527115 )
2018
18
Identification and Characterization of Fusarium proliferatum, a New Species of Fungi that Cause Fungal Keratitis. ( 29559666 )
2018
19
Two cases of fungal keratitis caused by Metarhizium anisopliae. ( 29560304 )
2018
20
Fungal keratitis caused by rare organisms. ( 29564417 )
2018
21
Corneal Debridement Combined with Intrastromal Voriconazole for Recalcitrant Fungal Keratitis. ( 29670766 )
2018
22
Expression of cytokines in aqueous humor from fungal keratitis patients. ( 29673332 )
2018
23
Mincle in the innate immune response of mice fungal keratitis. ( 29675368 )
2018
24
Ocular surface squamous neoplasia in a setting of fungal keratitis: a rare co-occurrence. ( 29691697 )
2018
25
Clinical analysis of fungal keratitis in patients with and without diabetes. ( 29715322 )
2018
26
Fungal keratitis caused by Laetisaria arvalis. ( 29735846 )
2018
27
Collagen Cross-Linked Therapeutic Grafts in Fungal Keratitis. ( 29739628 )
2018
28
Interface Fungal Keratitis After Descemet Stripping Automated Endothelial Keratoplasty: A Review of the Literature With a Focus on Outcomes. ( 29781928 )
2018
29
Two-photon microscopy of fungal keratitis-affected rabbit cornea ex vivo using moxifloxacin as a labeling agent. ( 29787746 )
2018
30
Mast Cell Activation Protects Cornea by Promoting Neutrophil Infiltration via Stimulating ICAM-1 and Vascular Dilation in Fungal Keratitis. ( 29849098 )
2018
31
Comparison of corneal collagen cross-linking (PACK-CXL) and voriconazole treatments in experimental fungal keratitis. ( 29862655 )
2018
32
Treatment of Metarhizium fungal keratitis in the United Kingdom. ( 29887606 )
2018
33
Fungal keratitis caused by acremonium: A case report and literature review. ( 29929826 )
2018
34
Epidemiology of fungal keratitis in Queensland, Australia. ( 29931733 )
2018
35
Alterations in the gut bacterial microbiome in fungal Keratitis patients. ( 29933394 )
2018
36
Fungal keratitis caused by a rare ocular pathogen, Gjaerumia minor: A case report. ( 29942188 )
2018
37
Fungal keratitis: An overview of clinical and laboratory aspects. ( 29992633 )
2018
38
Human Corneal Changes After Rose Bengal Photodynamic Antimicrobial Therapy for Treatment of Fungal Keratitis. ( 30028750 )
2018
39
Spectral Domain Anterior Segment Optical Coherence Tomography in Fungal Keratitis. ( 30095493 )
2018
40
Identification and biofilm development by a new fungal keratitis aetiologic agent. ( 30187586 )
2018
41
Candida dubliniensis: A novel cause of fungal keratitis. ( 30237975 )
2018
42
Management Algorithm for Fungal Keratitis: The TST (Topical, Systemic, and Targeted Therapy) Protocol. ( 30334872 )
2018
43
Correlation between pathogenic species and clinical findings, disease severity, and visual outcome in patients with fungal keratitis. ( 30403261 )
2018
44
Efficacy of Luliconazole Against Broad-Range Filamentous Fungi Including Fusarium solani Species Complex Causing Fungal Keratitis. ( 30422866 )
2018
45
Comment on "Surgical management of fungal endophthalmitis resulting from fungal keratitis". ( 28944212 )
2017
46
The role of Mincle in innate immune to fungal keratitis. ( 28141595 )
2017
47
Short Synthetic I+-Helical-Forming Peptide Amphiphiles for Fungal Keratitis Treatment In Vivo. ( 28081296 )
2017
48
Development of a Poly-I/-Lysine Contact Lens as a Drug Delivery Device for the Treatment of Fungal Keratitis. ( 28873175 )
2017
49
Comparison of Oral Voriconazole Versus Oral Ketoconazole as an Adjunct to Topical Natamycin in Severe Fungal Keratitis: A Randomized Controlled Trial. ( 28902012 )
2017
50
Fungal keratitis in the Republic of Ireland. ( 28524886 )
2017

Variations for Fungal Keratitis

Expression for Fungal Keratitis

Search GEO for disease gene expression data for Fungal Keratitis.

Pathways for Fungal Keratitis

Pathways related to Fungal Keratitis according to GeneCards Suite gene sharing:

(show all 19)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 CD209 CLEC4E CLEC7A MMP8 MMP9 TIMP1
2
Show member pathways
12.47 MMP8 MMP9 TIMP1 TIMP2
3
Show member pathways
12.4 TIMP1 TIMP2 TLR2 TLR4
4
Show member pathways
12.17 CD209 CLEC4E CLEC7A
5 12.04 MMP9 TLR2 TLR4
6
Show member pathways
11.95 CD209 CLEC4E CLEC7A
7 11.92 MMP9 TLR2 TLR4
8
Show member pathways
11.87 MMP8 MMP9 TLR2 TLR4 TREM1
9 11.8 CD209 CLEC7A TLR2 TLR4
10
Show member pathways
11.77 MMP9 TLR2 TLR4
11 11.61 CD209 CLEC4E CLEC7A TLR2 TLR4
12 11.58 MMP9 TIMP1 TIMP2
13
Show member pathways
11.55 MMP8 MMP9 TIMP1 TIMP2
14 11.54 CLEC7A TLR2 TLR4
15 11.37 MMP9 TIMP1 TIMP2
16 11.17 MMP9 TIMP2
17 11.07 MMP9 TLR4
18 10.93 MMP9 TIMP2
19 10.32 MMP9 TIMP1 TIMP2 TLR2

GO Terms for Fungal Keratitis

Cellular components related to Fungal Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 CD209 MMP8 MMP9 TIMP1 TIMP2 TREM1
2 collagen-containing extracellular matrix GO:0062023 9.54 MMP8 MMP9 TIMP2
3 cell surface GO:0009986 9.46 CD209 TIMP2 TLR2 TLR4
4 intrinsic component of plasma membrane GO:0031226 9.32 TLR2 TLR4
5 extracellular matrix GO:0031012 9.26 MMP8 MMP9 TIMP1 TIMP2
6 tertiary granule lumen GO:1904724 8.8 MMP8 MMP9 TIMP2

Biological processes related to Fungal Keratitis according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 neutrophil degranulation GO:0043312 9.87 MMP8 MMP9 TIMP2 TLR2
2 immune system process GO:0002376 9.83 CD209 CLEC4E CLEC7A TLR2 TLR4
3 positive regulation of nitric oxide biosynthetic process GO:0045429 9.64 MMP8 TLR4
4 toll-like receptor signaling pathway GO:0002224 9.64 TLR2 TLR4
5 collagen catabolic process GO:0030574 9.63 MMP8 MMP9
6 lipopolysaccharide-mediated signaling pathway GO:0031663 9.63 TLR2 TLR4
7 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.62 TLR2 TLR4
8 positive regulation of DNA binding GO:0043388 9.62 MMP8 MMP9
9 endodermal cell differentiation GO:0035987 9.61 MMP8 MMP9
10 positive regulation of interleukin-8 production GO:0032757 9.61 TLR2 TLR4
11 positive regulation of interferon-beta production GO:0032728 9.6 TLR2 TLR4
12 positive regulation of interleukin-12 production GO:0032735 9.59 TLR2 TLR4
13 positive regulation of interleukin-10 production GO:0032733 9.58 TLR2 TLR4
14 positive regulation of chemokine production GO:0032722 9.58 TLR2 TLR4
15 positive regulation of interleukin-6 production GO:0032755 9.58 MMP8 TLR2 TLR4
16 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.56 TLR2 TLR4
17 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.55 MMP8 TLR4
18 regulation of cytokine secretion GO:0050707 9.54 TLR2 TLR4
19 cell activation GO:0001775 9.52 TIMP1 TLR2
20 I-kappaB phosphorylation GO:0007252 9.51 TLR2 TLR4
21 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.5 MMP8 TLR2 TLR4
22 cellular response to lipoteichoic acid GO:0071223 9.49 TLR2 TLR4
23 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.48 TIMP1 TIMP2
24 regulation of neuroinflammatory response GO:0150077 9.46 MMP8 MMP9
25 positive regulation of tumor necrosis factor production GO:0032760 9.43 MMP8 TLR2 TLR4
26 innate immune response GO:0045087 9.43 CD209 CLEC4E CLEC7A TLR2 TLR4 TREM1
27 negative regulation of metallopeptidase activity GO:1905049 9.37 TIMP1 TIMP2
28 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.16 TLR2 TLR4
29 extracellular matrix disassembly GO:0022617 8.92 MMP8 MMP9 TIMP1 TIMP2

Molecular functions related to Fungal Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 metal ion binding GO:0046872 9.95 CD209 CLEC4E CLEC7A MMP8 MMP9 TIMP1
2 carbohydrate binding GO:0030246 9.5 CD209 CLEC4E CLEC7A
3 enzyme inhibitor activity GO:0004857 9.43 TIMP1 TIMP2
4 lipopolysaccharide binding GO:0001530 9.37 TLR2 TLR4
5 metalloendopeptidase inhibitor activity GO:0008191 9.26 TIMP1 TIMP2
6 signaling pattern recognition receptor activity GO:0008329 9.16 CLEC7A TLR2
7 lipopolysaccharide receptor activity GO:0001875 8.96 TLR2 TLR4
8 signaling receptor activity GO:0038023 8.92 CLEC4E TLR2 TLR4 TREM1

Sources for Fungal Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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