MCID: FNG016
MIFTS: 39

Fungal Keratitis

Categories: Eye diseases, Rare diseases

Aliases & Classifications for Fungal Keratitis

MalaCards integrated aliases for Fungal Keratitis:

Name: Fungal Keratitis 58
Mycotic Keratitis 58
Keratomycosis 58

Classifications:

MalaCards categories:
Global: Rare diseases
Anatomical: Eye diseases
Orphanet: 58  
Rare eye diseases


External Ids:

Orphanet 58 ORPHA519930

Summaries for Fungal Keratitis

MalaCards based summary : Fungal Keratitis, also known as mycotic keratitis, is related to corneal ulcer and keratitis, hereditary. An important gene associated with Fungal Keratitis is CLEC7A (C-Type Lectin Domain Containing 7A), and among its related pathways/superpathways are Innate Immune System and Degradation of the extracellular matrix. The drugs Amphotericin B and Riboflavin have been mentioned in the context of this disorder. Affiliated tissues include eye, endothelial and neutrophil, and related phenotypes are hematopoietic system and cardiovascular system

Wikipedia : 73 A fungal keratitis is an inflammation of the cornea that results from infection by a fungal organism.... more...

Related Diseases for Fungal Keratitis

Diseases related to Fungal Keratitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 244)
# Related Disease Score Top Affiliating Genes
1 corneal ulcer 31.3 MMP9 CLEC7A
2 keratitis, hereditary 31.3 TLR4 TLR2 MMP9
3 phaeohyphomycosis 30.2 CLEC7A CLEC4E
4 dermatophytosis 30.1 CLEC7A CLEC4E
5 chromoblastomycosis 29.9 MMP9 CLEC7A CLEC4E
6 candidiasis 29.7 TLR4 TLR2 CLEC7A
7 rosacea 29.6 TLR2 MMP9 MMP8
8 leprosy 3 29.5 TLR4 TLR2 CD209
9 bacterial infectious disease 29.4 TREM1 TLR4 TLR2
10 peritonitis 29.3 TLR4 TLR2 MMP8
11 aspergillosis 29.3 TLR4 TLR2 CLEC7A CD209
12 disease by infectious agent 29.2 TLR4 TLR2 CD209
13 fungal infectious disease 28.8 TLR4 TLR2 CLEC7A CLEC4E CD209
14 tinea nigra 11.0
15 hypopyon 10.7
16 endophthalmitis 10.6
17 yemenite deaf-blind hypopigmentation syndrome 10.6
18 corneal disease 10.5
19 conjunctivitis 10.3
20 blastomycosis 10.3 CLEC7A CLEC4E
21 tinea profunda 10.3 CLEC7A CLEC4E
22 tinea capitis 10.3 CLEC7A CLEC4E
23 tinea corporis 10.3 CLEC7A CLEC4E
24 subcutaneous mycosis 10.3 CLEC7A CLEC4E
25 keratoconus 10.3
26 corneal edema 10.3
27 keratopathy 10.3
28 acanthamoeba keratitis 10.3
29 pityriasis versicolor 10.3 CLEC7A CLEC4E
30 superficial mycosis 10.2 CLEC7A CLEC4E
31 corneal abscess 10.2
32 eye disease 10.2
33 amaurosis fugax 10.2 MMP9 MMP8
34 pneumocystosis 10.2 CLEC7A CLEC4E
35 venous insufficiency 10.2 TIMP1 MMP9
36 adenoiditis 10.2 TREM1 CLEC7A
37 autoimmune inner ear disease 10.2 TIMP1 MMP9
38 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2
39 fusariosis 10.2
40 blind hypotensive eye 10.2
41 scleritis 10.2
42 herpes simplex 10.2
43 lentigo maligna melanoma 10.2 TIMP1 MMP9
44 tendinopathy 10.2 TIMP2 MMP8
45 uveitis 10.1
46 haemophilus influenzae 10.1 TLR2 CLEC7A
47 cryptogenic organizing pneumonia 10.1 TIMP1 MMP9
48 mycobacterium abscessus 10.1 TLR2 CLEC7A
49 decubitus ulcer 10.1 TIMP1 MMP9
50 retinal detachment 10.1

Graphical network of the top 20 diseases related to Fungal Keratitis:



Diseases related to Fungal Keratitis

Symptoms & Phenotypes for Fungal Keratitis

MGI Mouse Phenotypes related to Fungal Keratitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.91 CD209 CLEC4E CLEC7A MMP9 TIMP1 TIMP2
2 cardiovascular system MP:0005385 9.87 CLEC4E MMP8 MMP9 TIMP1 TIMP2 TLR2
3 homeostasis/metabolism MP:0005376 9.85 CD209 CLEC4E CLEC7A MMP8 MMP9 TIMP1
4 immune system MP:0005387 9.61 CLEC4E CLEC7A MMP8 MMP9 TIMP1 TIMP2
5 neoplasm MP:0002006 9.1 MMP8 MMP9 TIMP1 TLR2 TLR4 TREM1

Drugs & Therapeutics for Fungal Keratitis

Drugs for Fungal Keratitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Amphotericin B Approved, Investigational Phase 4 1397-89-3 14956 5280965
2
Riboflavin Approved, Investigational, Nutraceutical, Vet_approved Phase 4 83-88-5 493570
3 Vitamin B2 Phase 4
4 Liposomal amphotericin B Phase 4
5
Moxifloxacin Approved, Investigational Phase 3 354812-41-2, 151096-09-2 152946
6
Tetracaine Approved, Vet_approved Phase 3 94-24-6 5411
7
Voriconazole Approved Phase 3 137234-62-9 71616
8
Natamycin Approved Phase 3 7681-93-8 5281099
9
Clotrimazole Approved, Vet_approved Phase 3 23593-75-1 2812
10
Miconazole Approved, Investigational, Vet_approved Phase 3 22916-47-8 4189
11
Povidone-iodine Approved Phase 3 25655-41-8
12
Povidone Approved Phase 3 9003-39-8 131751496
13
Iodine Approved, Investigational Phase 3 7553-56-2 807
14
Cadexomer iodine Experimental Phase 3 94820-09-4
15 Anesthetics Phase 3
16 Photosensitizing Agents Phase 3
17 Norgestimate, ethinyl estradiol drug combination Phase 3
18 Cytochrome P-450 CYP3A Inhibitors Phase 3
19 Cytochrome P-450 Enzyme Inhibitors Phase 3
20 Hormone Antagonists Phase 3
21 Hormones Phase 3
22 Ophthalmic Solutions Phase 3
23 Anti-Infective Agents, Local Phase 3
24 Anti-Infective Agents Phase 3
25 Antifungal Agents Phase 3
26 Anti-Bacterial Agents Phase 3
27 Pharmaceutical Solutions Phase 3
28 Plasma Substitutes Phase 3
29 Blood Substitutes Phase 3
30
Ofloxacin Approved 82419-36-1 4583
31
Itraconazole Approved, Investigational 84625-61-6 55283
32
Levofloxacin Approved, Investigational 100986-85-4 149096
33
Hydroxyitraconazole 108222

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cross-linking for Corneal Ulcers Treatment Trial Recruiting NCT02570321 Phase 4
2 Effectiveness of Corneal Accelerated Crosslinking Versus Conventional Treatment for Infectious Keratitis Unknown status NCT02865876 Phase 3
3 Combination Treatment of 5% Natamycin and 1% Voriconazole in Fungal Keratitis: a Prospective Randomized Double Masked Clinical Trial Unknown status NCT03230058 Phase 2, Phase 3 Group 1 Natamycin 5% Suspension + voriconazole 1% eye drops; Group 2 Natamycin 5% Suspension + Vehicle eye drops
4 Mycotic Antimicrobial Localized Injection for Treatment of Corneal Ulcers Completed NCT02731638 Phase 3 Intrastromal voriconazole;Natamycin
5 A Clinical Trial of the Treatment of Fungal Corneal Ulcers With Povidone-Iodine Terminated NCT00516399 Phase 3 povidone-iodine 1.25% ophthalmic solution;natamycin ophthalmic suspension, USP 5%
6 Mycotic Ulcer Treatment Trial Therapeutic Exploratory Study Completed NCT00557362 Phase 1, Phase 2 Natamycin 5%;Voriconazole
7 Clinical & Visual Outcomes of Collagen Cross Linking for Fungal Keratitis Unknown status NCT02328053 Topical anti-fungal therapy
8 UVX as an Adjuvant in the Treatment of Fungal Keratitis Unknown status NCT03138785 topical voriconazole / levofloxacin systemic itraconazole
9 A Multi-center, Open-label, Single-arm Study Assess the Collagen Ophthalmic Matrix for Anterior Lamellar Keratoplasty Recruiting NCT04054817

Search NIH Clinical Center for Fungal Keratitis

Genetic Tests for Fungal Keratitis

Anatomical Context for Fungal Keratitis

MalaCards organs/tissues related to Fungal Keratitis:

40
Eye, Endothelial, Neutrophil, T Cells

Publications for Fungal Keratitis

Articles related to Fungal Keratitis:

(show top 50) (show all 1489)
# Title Authors PMID Year
1
Statistical optimization of hyaluronic acid enriched ultradeformable elastosomes for ocular delivery of voriconazole via Box-Behnken design: in vitro characterization and in vivo evaluation. 61
33342315 2021
2
Aspergillus fumigatus-Stimulated Human Corneal Epithelial Cells Induce Pyroptosis of THP-1 Macrophages by Secreting TSLP. 61
33118609 2021
3
The global incidence and diagnosis of fungal keratitis. 61
33645500 2021
4
Topical Corticosteroids and Fungal Keratitis: A Review of the Literature and Case Series. 61
33799843 2021
5
Chlorhexidine for the Treatment of Fusarium Keratitis: A Case Series and Mini Review. 61
33805369 2021
6
Enhanced in vivo antifungal activity of novel cell penetrating peptide natamycin conjugate for efficient fungal keratitis management. 61
33737097 2021
7
Evaluation of Polymerase Chain Reaction over Routine Microbial Diagnosis for the Diagnosis of Fungal Keratitis. 61
33633022 2021
8
Late-onset recurrent Acremonium fungal keratitis after therapeutic penetrating keratoplasty. 61
33711269 2021
9
Isorhamnetin Ameliorates Aspergillus fumigatus Keratitis by Reducing Fungal Load, Inhibiting Pattern-Recognition Receptors and Inflammatory Cytokines. 61
33783487 2021
10
Successful management of pediatric pythium insidiosum keratitis with cyanoacrylate glue, linezolid, and azithromycin: Rare case report. 61
33779337 2021
11
In situ forming and mucoadhesive ophthalmic voriconazole/HPβCD hydrogels for the treatment of fungal keratitis. 61
33540021 2021
12
Tintelnotia destructans Keratitis: A Clinicopathological Report and Review of the Literature. 61
33252388 2021
13
Clinical and mycological characteristics of keratitis caused by Colletotrichum gloeosporioides: A case report and review of literature. 61
33690215 2021
14
A case of contact lens-induced fungal keratitis caused by Didymella heteroderae. 61
33656682 2021
15
Invited commentary on "Deep Anterior lamellar keratoplasty with Cross-linked Acellular Porcine Corneal Stroma to Manage Fungal Keratitis". 61
33682969 2021
16
Estimates of serious fungal infection burden in Côte d'Ivoire and country health profile. 61
33259981 2021
17
Subconjunctival enucleation with orbital implant placement in standing horses: 20 cases (2014-2017). 61
33683960 2021
18
Incidence and outcome of transplantation of fungal-culture-positive donor corneoscleral tissue in optical keratoplasty. 61
33205371 2021
19
A systematic review of gut microbiome and ocular inflammatory diseases: Are they associated? 61
33595467 2021
20
Early Penetrating Keratoplasty after interface fungal keratitis in Descemet Membrane Endothelial Keratoplasty. 61
32653314 2021
21
[Contact lens-associated superficial stromal keratitis caused by Paecilomyces lilacinus]. 61
32211923 2021
22
[Purpureocillium lilacinum : Atypical pathogen of mycotic keratitis in an immunocompetent patient]. 61
33580805 2021
23
Microbiological diagnosis of Acanthamoebic keratitis: experience from tertiary care center of North India. 61
33618203 2021
24
Infectious Keratitis After Boston Type 1 Keratoprosthesis Implantation. 61
33630813 2021
25
Incidence of Fungal Infection in Positive Donor Rim Cultures after Corneal Transplantation. 61
33560899 2021
26
Purpureocillium roseum sp. nov. A new ocular pathogen for humans and mice resistant to antifungals. 61
33064905 2021
27
[Fungal keratitis associated with the use of contact lenses (clinical case)]. 61
33610153 2021
28
Keratitis by Scopulariopsis brevicaulis Fungus After LASIK - A Case Report. 61
33633469 2021
29
Identification and molecular characterization of Subramaniula asteroides causing human fungal keratitis: a case report. 61
33461505 2021
30
Treating Fungal Keratitis with Oral Voriconazole Only: A Case Series. 61
33339060 2021
31
Topical Corticosteroids for Infectious Keratitis Before Culture-Proven Diagnosis. 61
33623362 2021
32
Periconia species - An unusual fungal pathogen causing mycotic keratitis. 61
33610254 2021
33
Bipolaris keratitis following photorefractive keratectomy: Case report. 61
33412407 2021
34
Infectious keratitis: trends in microbiological and antibiotic sensitivity patterns. 61
33469134 2021
35
Recent advances on mycotic keratitis caused by dematiaceous hyphomycetes. 61
33462841 2021
36
Re: Prajna et al.: Cross-Linking-Assisted Infection Reduction: a randomized clinical trial evaluating the effect of adjuvant cross-linking on outcomes in fungal keratitis (Ophthalmology. 2020;127:159-166). 61
32800613 2021
37
Re: Prajna et al.: Cross-Linking-Assisted Infection Reduction: a randomized clinical trial evaluating the effect of adjuvant cross-linking on outcomes in fungal keratitis (Ophthalmology. 2020;127:159-166). 61
32896387 2021
38
Inhibition of miR-665-3p Enhances Autophagy and Alleviates Inflammation in Fusarium solani-Induced Keratitis. 61
33481985 2021
39
The role of fungi in fungal keratitis. 61
33249061 2021
40
The cGAS-STING signaling pathway contributes to the inflammatory response and autophagy in Aspergillus fumigatus keratitis. 61
33227296 2021
41
A Case of Black Fungal Keratitis Caused by Biatriospora mackinnonii. 61
33528226 2021
42
Promising Antifungal Potential of Engineered Non-ionic Surfactant-Based Vesicles: In Vitro and In Vivo Studies. 61
33389224 2021
43
Exosomes derived from thymic stromal lymphopoietin-treated dendritic cells regulate T helper 17/regulatory T cell differentiation via miR-21/Smad7 axis. 61
33253708 2021
44
Fabrication and Characterization of Chitosan/Poly(Lactic-Co-glycolic Acid) Core-Shell Nanoparticles by Coaxial Electrospray Technology for Dual Delivery of Natamycin and Clotrimazole. 61
33748084 2021
45
Case Report: Successful Management of Refractory Keratomycosis in an Alpaca Using Penetrating Keratoplasty and Combination Antifungal Therapy (Caspofungin 0.5% and Terbinafine 1%). 61
33791355 2021
46
Indolent keratitis due to fungus of Malbranchea species. A case report. 61
33304572 2020
47
TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis. 61
33346778 2020
48
Endothelial Biopsy for the Diagnosis and Management of Culture-Negative Retrocorneal Fungal Keratitis With the Assistance of Optical Coherence Tomography Imaging. 61
33332896 2020
49
[Incidence of fungal keratitis at the Hospital Nacional de Clínicas, Córdoba]. 61
33351379 2020
50
Mycotic Keratitis in a Tertiary Hospital in Northeastern Malaysia 61
33389932 2020

Variations for Fungal Keratitis

Expression for Fungal Keratitis

Search GEO for disease gene expression data for Fungal Keratitis.

Pathways for Fungal Keratitis

GO Terms for Fungal Keratitis

Cellular components related to Fungal Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix GO:0031012 9.46 TIMP2 TIMP1 MMP9 MMP8
2 cell surface GO:0009986 9.35 TLR4 TLR2 TIMP2 CLEC7A CD209
3 intrinsic component of plasma membrane GO:0031226 9.26 TLR4 TLR2
4 tertiary granule lumen GO:1904724 8.8 TIMP2 MMP9 MMP8

Biological processes related to Fungal Keratitis according to GeneCards Suite gene sharing:

(show all 32)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.95 TLR4 TLR2 CLEC7A CLEC4E CD209
2 positive regulation of gene expression GO:0010628 9.92 TLR4 TLR2 MMP8 CLEC7A
3 neutrophil degranulation GO:0043312 9.91 TLR2 TIMP2 MMP9 MMP8
4 innate immune response GO:0045087 9.73 TREM1 TLR4 TLR2 CLEC7A CLEC4E CD209
5 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.69 TLR4 TLR2 MMP8
6 positive regulation of interleukin-8 production GO:0032757 9.67 TLR4 TLR2 CLEC7A
7 positive regulation of chemokine production GO:0032722 9.65 TLR4 TLR2
8 positive regulation of interferon-beta production GO:0032728 9.65 TLR4 TLR2
9 lipopolysaccharide-mediated signaling pathway GO:0031663 9.65 TLR4 TLR2
10 positive regulation of nitric oxide biosynthetic process GO:0045429 9.65 TLR4 MMP8 CLEC7A
11 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.64 TLR4 TLR2
12 positive regulation of DNA binding GO:0043388 9.64 MMP9 MMP8
13 endodermal cell differentiation GO:0035987 9.63 MMP9 MMP8
14 positive regulation of cytokine production involved in inflammatory response GO:1900017 9.63 TLR4 CLEC7A
15 positive regulation of stress-activated MAPK cascade GO:0032874 9.62 TLR4 CLEC7A
16 positive regulation of reactive oxygen species biosynthetic process GO:1903428 9.61 TLR4 MMP8
17 positive regulation of interleukin-12 production GO:0032735 9.61 TLR4 TLR2 CLEC7A
18 positive regulation of nitric-oxide synthase biosynthetic process GO:0051770 9.6 TLR4 TLR2
19 I-kappaB phosphorylation GO:0007252 9.59 TLR4 TLR2
20 cell activation GO:0001775 9.58 TLR2 TIMP1
21 regulation of neuroinflammatory response GO:0150077 9.58 MMP9 MMP8
22 positive regulation of interleukin-10 production GO:0032733 9.58 TLR4 TLR2 CLEC7A
23 cellular response to UV-A GO:0071492 9.57 TIMP1 MMP9
24 cellular response to lipoteichoic acid GO:0071223 9.56 TLR4 TLR2
25 negative regulation of metallopeptidase activity GO:1905049 9.54 TIMP2 TIMP1
26 negative regulation of membrane protein ectodomain proteolysis GO:0051045 9.52 TIMP2 TIMP1
27 positive regulation of matrix metallopeptidase secretion GO:1904466 9.46 TLR4 TLR2
28 positive regulation of interleukin-6 production GO:0032755 9.46 TLR4 TLR2 MMP8 CLEC7A
29 positive regulation of cellular response to macrophage colony-stimulating factor stimulus GO:1903974 9.37 TLR4 TLR2
30 detection of fungus GO:0016046 9.32 TLR4 CLEC7A
31 positive regulation of tumor necrosis factor production GO:0032760 9.26 TLR4 TLR2 MMP8 CLEC7A
32 extracellular matrix disassembly GO:0022617 8.92 TIMP2 TIMP1 MMP9 MMP8

Molecular functions related to Fungal Keratitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor activity GO:0038023 9.61 TREM1 TLR4 TLR2
2 carbohydrate binding GO:0030246 9.54 CLEC7A CLEC4E CD209
3 lipopolysaccharide binding GO:0001530 9.4 TLR4 TLR2
4 metalloendopeptidase inhibitor activity GO:0008191 9.32 TIMP2 TIMP1
5 NAD+ nucleotidase, cyclic ADP-ribose generating GO:0061809 9.26 TLR4 TLR2
6 NAD(P)+ nucleosidase activity GO:0050135 9.16 TLR4 TLR2
7 lipopolysaccharide receptor activity GO:0001875 8.96 TLR4 TLR2
8 pattern recognition receptor activity GO:0038187 8.8 TLR2 CLEC7A CLEC4E

Sources for Fungal Keratitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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